Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PCNA XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
VIM XRCC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NHEJ1 XRCC4 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
SUMO1 XRCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16478998
CAV1 CAVIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001640 24013648
CAVIN1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001640 24013648
VIM NEFL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
NEFL SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NEFL TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR1 AICDA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23181348 19139166
TP53 ANXA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TDG APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11864601
APEX1 CCNO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18259689
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
AR FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11690559 20610535
AR CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24218937 20610535
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17011549 11250938
AR RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069693 20610535
AR TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21303954 20610535
AR VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15805579 16425262
TDG AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17129768
RXRA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15650026
AR RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15650026
ESR2 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12138116 16423895
CCNO XRCC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18971944 7294748
STAT3 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22218594
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
CREBBP VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10406465
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
TDG DDX39B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
WFS1 DNMT3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DNMT3B DNMT3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20426865 15362956
DNMT3A DNMT3L â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18544626 17965599
MYC DNMT3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15616584 19786833
TDG DNMT3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17175537
DNMT3A TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17175537
UBE2I DNMT3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18762900 11735126
NES EBF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TCF4 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219834 17410209
SUMO3 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7941484 19680224
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20339243 21467818
TP73 EP300 â—¼   ACETYLATION ✅ 2.0 0.8 intact 11804596 5215037
EP300 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 20089040
ESR1 WFS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
THRA ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11578528 11687272
ESR1 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11477071
NCOA1 ESR1 â—¼   PROXIMITY 2.0 0.8 intact 5222291 17627277
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR2 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10428965 17562975
RARA ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9841885
ESR2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9841885
WFS1 FAM111B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FAM111B GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGF2 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23882217 20338032
TP73 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21245298 10435630
TP63 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9405685 9032395
PGR GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19423654 22669741
TDG GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRN TAX1BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 HSPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HSPB1 TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IKZF1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
STAT3 JUNB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11533249
MRFAP1 WFS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MRFAP1 PRPS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
RXRA NCOA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17673910 5223765
NCOA1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16186500 14551261
NR3C1 RXRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10860926 12573484
RXRA NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12573484 23331499
TDG NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17129768
NR3C1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12573484 23331499
PGR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14500579 16175636
TDG PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17129768
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
PML STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12506013 16189514
POLL XRCC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18971944 7294748
TP53 PRNP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24339999 19064990
WFS1 PRPS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRPS1 TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAD23B SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12505994
RARA SCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11397803
SUMO2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19041634
RNF11 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
TAX1BP1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
RNF11 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19131965
TDG RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TAX1BP1 RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
RNF4 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 SCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 SERPINB9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
VIM SIRT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
WFS1 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2I SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
VIM SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TDG SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 SKIL â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22674574
TDG SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21294585 11042172
TDG SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA VIM â—¼   COLOCALIZATION 2.0 0.8 intact 16678164 5218597
UBE2I SNIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SNIP1 TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
UBE2I SOX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15788563
TP53 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11807984 16567167
STAT3 VIM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19088723 14712222
TDG SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218717 16763556
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
VIM SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SUMO3 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11451954 17938407
SUMO2 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1004248107 20534433
VIM SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP63 TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22232078
TCF4 VIM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12750294
WFS1 TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TTR TDG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP73 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19815500 0905867106
VIM TTR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBE2I XPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17693435 16030353
TDG CFDP1 â—¼   KO_DOWN_REGULATES ✅ - -0.81 0.8 PKG 28854368
TDG CKS1B â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
APEX1 EP300 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CREBBP TCF4 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
JUNB EP300 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 21937452 15308641 17510411
CREBBP RXRA â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
XRCC4 NTHL1 â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
DNMT3A DNMT3B â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
ESR1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
ESR1 PURA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 31527615
MX1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25447205 11716541
MYC TDG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 26496610
MYC SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
TDG SLC3A2 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
NHEJ1 PRPS1 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
TDG MIPOL1 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
ESR1 PGR â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
TDG EPHA7 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
TDG CDH2 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
TDG RIPK1 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
PCNA UHRF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26496610 30357346
ESR2 EP300 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 18765668 11500849
ESR1 JUNB â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31527615 11477071
MYC HSPB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
XPC RAD23B â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 34591642
SUMO2 SETX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19471022 21252943 16524884 21693764
UBE2I SMAD4 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 5217094 15231748
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
TDG SLC39A14 â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
NHEJ1 SUMO2 â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
TDG MRFAP1 â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
NR3C1 STAT3 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
TDG CBR3 â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
RAD9A PCNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12400013 16189514 11994305
CDK4 P53 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28218424 28205554 28628118
TDG P53 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18951877 10961991
TDG P73 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18951877 10961991
ESR1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15961505 31527615
ESR1 RXRA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9121466 23403292 9717844
ESR1 NCOA1 â—¼   PROXIMITY ✅ 0.84 0.84 mint 17627277 5222291
NHEJ1 FADS2 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
CREBBP NR3C1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
TDG LIMD2 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
HSPB1 TP53 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
THA TDG â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12874288 16189514
RD23B TDG â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12505994 16189514 16713569 34111398
PML RXRA â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16540467 10610177
TDG DTL â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
TDG CAVIN1 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
TDG CYP51A1 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
HUS1 PCNA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11077446 16189514
PCNA APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10559261 11601988 16189514
CBP STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11239394 15653507 15649887
P53 APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15824742 16189514 16713569 9119221
NCOA1 THA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11435616 15249124 10379889 11117530 9849963 9804773 15140878
SMAD4 EP300 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18215124 25514493 10887155 22033265 9679056 14612423 9843571
NTHL1 ERCC5 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15358233 16713569 9927729
ESR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
ESR1 RARA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 25604459 25303530 9717844
RARA SUMO1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24819975 15171703
SNIP1 SMAD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10887155 16189514
SUMO1 SUMO3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24654937 25027693 17938407 21098080 15576338
NHEJ1 PAIP2 â—¼   KO_UP_REGULATES ✅ + 0.86 0.86 PKG 28854368
NHEJ1 TDG â—¼   KO_UP_REGULATES ✅ + 0.86 0.86 PKG 28854368
TDG EBF2 â—¼   KO_DOWN_REGULATES ✅ - -0.87 0.86 PKG 28854368
P73 P53 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25417702 11238924 9891077 21508668 9802988
ANXA1 RIPK1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 29021293 21383699
MYC EP300 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12776737 16287840 32140074 15616592 16126174 17157259
SUMO2 PML â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25027693 21148299 23543742 17000644 20797634 22155184 21779164 19553342 9452416 17081986 16713569 24637324 21693764 19471022 21252943 15940266 16189514 22578841 20826694 24190887 28851805
TDG RARA â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12874288 24394593
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PCNA UBE2I â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RXRA THRA â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
NHEJ1 ANXA3 â—¼   KO_UP_REGULATES ✅ + 0.87 0.87 PKG 28854368
CREBBP TDG â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
TDG MID1IP1 â—¼   KO_UP_REGULATES ✅ + 0.87 0.87 PKG 28854368
EP300 TP73 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PML RARA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SETX SLC20A1 â—¼   KO_DOWN_REGULATES ✅ - -0.88 0.87 PKG 28854368
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EP300 CBP â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 30110629 9267036 15598887 31753913 17970752 25314079 10899165
CBP SUMO1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23395904 28630323 27129204
P53 HSPB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 17184779 25241761 31615977 16169070 16713569
EP300 VDR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32603375 15647825 21988832 20089040
SMAD4 JUNB â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10220381 16189514 15231748
STAT3 PML â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16189514 12506013
PML RNF4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CCNO PCNA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10393198 12171929
PCNA ERCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10408173 16189514 9305916 16713569
MYC CBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16878156 35140242 29467282 12776737
SUMO1 P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16732283 23150668 15017387 10961991 18583933 21316347 15327968 23825024 17369817 23543742 15931224 16713569 19684601 15144954 11867732 23604351 12917636 17060459 15576338 15242646 19246003 23772552 16189514 20534433 22214662 20972456 10562557 10788439 16122737 20861261 32807901
MYC P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21150319 30415952 28205554 28628118
P53 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17545634 26556313 10766163 16713569 21761334
P73 MYC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12080043 11844794
XRCC1 APEX1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28986522 19934257 11707423 16713569
MYC CDK4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22094256 28205554 21988832 28628118
TDG ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12874288 16282588
NCOA1 ESR2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11500849 10809226 11014206 19126643 15604093 10731636 11376110 14715875 12554772
MYC PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17146439 21150319 32592588 30415952 15735755
NCOA1 STAT3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11773079 17471507 16713569
RNF4 PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18708055 29180619 24907272 19380586 18408734 15707587 21252943 22388745 24637324 23028697
RARA PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 1311253 10882117 11050004 16189514 16540467 20159610 12935927 16713569 10610177 18073335 17560333
TDG SELENBP1 â—¼   KO_DOWN_REGULATES ✅ - -0.9 0.89 PKG 28854368
NCOA1 THRA â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
NCOA1 PGR â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
AR NCOA1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
XRCC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30260704 20227374 16713569 34111398 15107487
PCNA DTL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16861906 25154416 21725088 30301766 30623174 29424068 20129063
XRCC4 NHEJ1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21070942 31548606 21768349 17567543 26774286 18064046 21349273 29997244 16439205
NCOA1 CBP â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9445475 9192892 11003650 11113179 12482968 15615775 8616895 12163591 11971985 16713569 16860316 14722092
TDG CBP â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11864601 24748645 24532795 28680062 17060459 24394593
CBP P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9288775 10848610 19234109 28630323 16537920 10551785 27618436 9194564 10648616 16713569 20962272 19880525 19220000 14722092 10196247 10473588 25451029 12154097 17434128 19357310 12426395 19805293 10823891 22084066 25314079 19166313 15632413 18485870 11782467 18753379 14759370 26976603 23908595 21390126
CBP PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17239008 25733689 12234245 12142048 10077561 12622724 16713569 10610177
CBP ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18765668 14766010 11113179 17400812 8616895 9192902 11782371 23403292 16417649 27420286
EP300 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 29706626 25156994 12724314 23728348 16543236 12501250 9652736 9194564 18243116 9194565 19339993 16678111 16611888 11359905 11782467 12162806 14612423 14759370 15186775 15664194 9288740 23402884 17452980 24157709 9891054 12499368 19234109 27818144 16537920 17977830 15295102 10518217 16713569 26625199 16928824 11070080 17906639 23870121 23796514 15558054 17438265 25867071 17189186 18485870 11907332 15542844 19217391 32807901 16438982 31167125 15337767 10490106 22731250 12690203 25288747 18612383 23329847 24821727 26302407 9809062 16959611 22074660 19218448 16782091 23880760 33196849 25753752 28757384 18391200 16024799 25651062 16135789 22013068 11433299 9744860 10601022 21187340 11804596 23307557 10942770 15509808 20234175 21471221 26229107 19805293 22266186 15965232 23010591
P53 PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21057547 20972456 11704853 16007146 14976551 25241761 15375079 11025664 22869143 12006491 16713569 12915590 11080164 16189514
EP300 P73 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15175157 15454570 25675294 19218448 18663001 10648616 11804596 15893728
EP300 APEX1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20856196 19934257 14633989 30110629 20808282
APEX1 TDG â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11889051 15823533 18805789
TP53 APEX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18208837
PURA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19790234 18413735
AR NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24315100 15219414 20610535
AR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24119295 21796528 17932034
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
TCF4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12799378 16713569
CAV1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23634843 11563984 22230296 19595769
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
MYC CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10918582 18444242 11258956
PRNP CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10988071 16713569
MYC CDC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10899308 17093053
SNCA CDK4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RARA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23321499 16417649 21110951
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
NCOA1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9259327 10409727 23874500 11014206 15604093 12554772 16282588 9427757 11113179 18451880 9121466 10598586 16713569 11165056 14715875 11376110 9774463 10760302 20608937 9192892 11003650 26487511 11867769 10454579 12574227 17363140 9773983 10731636 11358671 11250900 11682626 23975195 17627277 16606617 12630920 12714702 9192902 12738788 16957778 15140878
ESR2 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19022902 19746436 10706629 12630920 9473491 21182203 29509190 17991765
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
ESR1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15961505 24119295 18404132
ESR1 GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15028626 12810571 22962310
ESR1 TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12459033
ESR1 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15664452 17556531 12710998
RXRA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
TDG ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12874288 17129768
ESR1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
STAT3 ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23295773 21546410
ESR2 TDG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR2 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR2 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15664452 17088408 17556531
TP53 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8090761 10029407
GADD45A TP53 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45A VIM â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
STAT3 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16527988 14715258
RAD9A HUS1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 26088138 14624239 14681455 12628935 9872989 11907025 32296183 10777662 10852904 19464297 11994305 28514442 16189514 15314187 11340080 10359610 26186194 14611806
STAT3 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10497240 17204573 9325164
MYC RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC NTHL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
RARA NCOA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12138096 16456540 9192892 23975195 9121466 10454579 16606617 17475621 21478865 17363140 20543827 17641689 16713569 10082574 10760302 12665583 20338915
TDG NKX2-1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17129768 11438542
TP63 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
TP53 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11080152 16713569
NR3C1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11080152 16713569
PGR SUMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19211567 17717077 17020914
PGR UBE2I â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19211567 17717077 17020914
PGR TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
SUMO1 PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15017387 15561718 28851805 16501610 19217413 22155184 22875967 24654937 31879127 21779164 20188669 9885291 9452416 17081986 21098080 22406621 18625722 21305000 17344210 17027752 11160742 19380586 23604351 23830076 17081985 9427741 11080164 16189514 23028697 21057547 19015637 20972456 8806687 20826694 24190887 25497731 17036045 11948183 9756909 18474224
TDG PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15569683 16189514 17060459
PML UBE2I â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
THRA RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15650024
RARA THRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15650024
SUMO1 RNF4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24844634 23086935 29180619 32296183 15707587 24151981 24907272
RNF4 SUMO1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
VDR RXRA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10733574 15604093 12847098 17500032 17786964 12796488 15829977 15647825 20153625 11075811 15888456 9632709 21988832 27728806 15890193 10224118 16750418 16357103 11514567 20564192 14726489 15805579 26329759 11149488 11124027 21478865 10037600
SMAD4 SKIL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 15231748 10531062 15761153 17469184 25609649 12764135 25059663
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
TP53 SUMO2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
TP53 SUMO3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
SUMO3 TDG â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25027693 11889051 16620772
SUMO3 TTR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16462763 16651407 18431400
TP73 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16413471 21436470 18026135
TP73 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11238924 19815500 10373484
NHEJ1 YBX2 â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
TDG SOX3 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
GADD45A PCNA â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
SETX CDC6 â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
TDG MT1X â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
XPC SPP1 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
NCOA1 VDR â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
TDG OLFML3 â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
TDG CDK4 â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
XRCC4 UHRF1 â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
RNF4 SUMO2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TDG TAX1BP1 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
NHEJ1 CAVIN1 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
TP53 TF â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.92 PKG 28854368
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
TDG TF â—¼   KO_UP_REGULATES ✅ + 0.93 0.93 PKG 28854368
TP53 RPL22L1 â—¼   KO_DOWN_REGULATES ✅ - -0.94 0.93 PKG 28854368
TDG PAN2 â—¼   KO_DOWN_REGULATES ✅ - -0.95 0.94 PKG 28854368
XRCC4 REEP6 â—¼   KO_DOWN_REGULATES ✅ - -0.95 0.94 PKG 28854368
TDG GJA1 â—¼   KO_UP_REGULATES ✅ + 0.94 0.94 PKG 28854368
RXRA RARA â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5212283 10698945
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
SUMO2 TDG â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
TDG POLL â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
TDG UHRF1 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
XRCC4 TWSG1 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
PCNA POLL â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
ERCC5 TDG â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
DNMT3B DNMT3L â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
THA RXRA â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 1314167 11117530 15604093 19422879 1331778 16189514
RD23B XPC â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 28514442 33961781 24258024 24981860 28760956 28473198 21962512 17154534 10488153 22431748 16713569 10873465 9164480 9372924 11279143 9372923 9734359 11259578
SUMO3 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
CREBBP SUMO1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
SETX PAIP2 â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
RAD9A RAD1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11907025 25091155 33961781 25602520 10777662 16189514 15314187 26088138 10852904 11340080 10359610 11994305 11572977 26186194 12628935 14611806 28514442 9872989
DTL PCNA â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SUMO1 TDG â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CREBBP NCOA1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RAD23B XPC â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
TDG SCD â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
NHEJ1 XRCC4 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ESR2 NCOA1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NCOA1 NR3C1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
PML SUMO1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SKIL SMAD4 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
CDK4 PCNA â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
NHEJ1 TWSG1 â—¼   KO_UP_REGULATES ✅ + 0.98 0.98 PKG 28854368
RXRA VDR â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
NCOA1 RARA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RARA RXRA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ESR1 NCOA1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
DNMT3A DNMT3L â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
TDG PAIP2 â—¼   KO_UP_REGULATES ✅ + 0.98 0.98 PKG 28854368
NCOA1 RXRA â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
HUS1 RAD9A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RAD1 RAD9A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SUMO2 UBE2I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
TDG LEFTY1 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
TP53 OLFML3 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PCNA XRCC1 â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA GADD45A â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
PCNA XRCC1 â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA GADD45A â—¼   REGULATES ✅ 18.0 1.0 ACSN 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
MYC PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7597041 18358094 22911891 18809243 1280813111085504 11085504
ERCC5 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18079701 10408173 16713569 19279666 9305916 20713449
HUS1 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11077446 16189514
GADD45A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7784094 23485469 10973963 7973727 10828065 16189514 20460379 7478510
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
PCNA POLL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12368291 11784855 16174846 16189514 12081642
XRCC4 POLL â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 16439204 17470781 22529269 15451442 14561766 12077346 10757784 9259561 16439205 11702069 18046455 9430729 12509254
NHEJ1 XRCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22228831 21349273 18064046 21070942 17567543 29997244 16439205 21768349
TP53 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23677994 19501055 18220474 21382456
MYC APEX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14519204 11983916 12695333 11085504
EP300 APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14633989 20856196 20711647
APEX1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15735682 20032196
APEX1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18786561 19180539 9119221 19737086 16713569
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
NCOA1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15514032 12163482 23145053 11673464
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
AR PRPS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
AR CDH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18535113 17297473 20610535
AR THRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
AR CDC6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24583551 18541154 19520769 20610535
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
NR3C1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
HSPB1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19767773 17974989
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
UBE2I AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
AR UBE2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
AR NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
HUS1 CDC6 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
RAD1 CDC6 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
MYC CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15208653 12835716 24951594 21384303 14519204 22395148 10688915 17728244 11983916 18414489
MYC CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21988832 11602341 17093053 22094256
TP73 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10648616 21245298 11172610 10435630
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
NCOA1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10777539 15671023 12748280 11463834 14966289 19194461 9792627 18193094 11747826 17400812 17244199 9223281 10594042
TDG CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11864601 17129768 24748645
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
DNMT3L DNMT3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11934864 25383530 15105426 12777184 15861382 17687327
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11804596 19407812 15175157 19788416 12660246 19218448 10648616 15454570 16998810 25675294 15893728 18663001
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11864601
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18234909 11522780 9869301 10428965 12761896
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
ESR1 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15833836 10960840 11174852 8923463
ESR1 SERPINB9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11682627 14617632
ESR1 PGR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 12829318 12554765 12446585 11000528 15019994 8043503 23027806 9058379 9717846 18414489 12706304 10835496 16293641 18784357 12761896 8145766 22543272 15743834 8530508 10894148
PGR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 22396492 16168121 12612073 11000528 18988627 26153859
NCOA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 18451880 9192892 16957778 11014206 16713569 17627277 23975195 15140878 15604093 12738788 17363140 11003650 10454579 16606617 26487511 11165056 10760302 10731636 12630920 14715875 9773983 9427757 9121466 20608937 12714702 9259327 9192902 11358671 10598586 12574227 11113179 12554772 11682626 9774463
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ESR2 PGR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16293641 12761896 11014241 19001520 9717846
SMAD4 FGF2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
STAT3 FGF2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15721278 9190899 10913183 15021909 14519204 9811446 21835778
TP53 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10749144 22801474 11221850 15031557 22262183 10321740 17700520 11420680 10094833 23114628 8892753 23948959 9405685 21394211 9931282 10435630 12007564 15721278 17440969 23576563 9566896 9233781 21836608 21245169 15186775 17063488 9154806 10327059 9191059 17344317 9519881 20797428 18350249 7624148 10566557 17084916 16714289 20840860 15735726 12806965 18225552 16581545
TP53 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16990795 15603758 14627995
HSPB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 25241761 16169070 16713569 17184779
HUS1 RAD1 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 15871698 16216273 16697054 16713580 16731526 16805667 16879101 16885023 17102137 17116885 17129768 17296725 17303408 17384638 17395641 17426133 17493829 17582221 17855402 18469862 18543256 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 23507534 8943031 9524127
HUS1 TDG â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 14726013 15459660 15703371 16697054 16713580 17129768 17493829 17855402 18543256 19847258 8943031 9524127
HUS1 RAD1 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 15871698 16216273 16697054 16713580 16731526 16805667 16879101 16885023 17102137 17116885 17129768 17296725 17303408 17384638 17395641 17426133 17493829 17582221 17855402 18469862 18543256 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 23507534 8943031 9524127
HUS1 TDG â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 14726013 15459660 15703371 16697054 16713580 17129768 17493829 17855402 18543256 19847258 8943031 9524127
MYC JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 2123531 7775604 12695333 18838534 18414489
TCF4 MYC â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
PGR MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8701093 9408078 22396492 9305935 22892083 10651641
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
TCF4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21533051 19778454 15928669 20133699 18852287 19561604 19662654
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
TCF4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
NCOA1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11773079 16713569 15313931
NCOA1 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12529333 7481822 10757795 19706513 21273440 16352595 16728408 10722692
NCOA1 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12612084 23975195 17786964 15604093 9878542 11124027 11149488 9121466 12403843 12796488 10224118 11075811
NHEJ1 POLL â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 16439204 17470781 22529269 15451442 14561766 12077346 10757784 9259561 16439205 11702069 18046455 9430729 12509254
SUMO1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12193561 12144530
SUMO1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22875967 9756909 25497731 17036045 21057547 18931695 19217413 8806687 16189514 17081985 11080164 11948183 9885291 19380586 17344210
RNF4 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23028697 18708055 15707587 24907272 18408734 21252943 22388745 24637324 19380586
RAD1 TDG â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 14726013 15459660 15703371 16697054 16713580 17129768 17493829 17855402 18543256 19847258 8943031 9524127
RAD1 TDG â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 14726013 15459660 15703371 16697054 16713580 17129768 17493829 17855402 18543256 19847258 8943031 9524127
RARA RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 15528208 19345331 16713569 16769902 21988832 23331499 14521715 15604093 21071413 10828175 10698945 18988627 12393611 25303530 16224062 25241761 1310351 21478865 17641689 7760852 9415406 9121466 7705655 9582446 15171703 10882070 1314167 12052862 31700049
VDR RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 14726489 16357103 17786964 16750418 11514567 20564192 11149488 12796488 21988832 12847098 23331499 15604093 10037600 11094341 9632709 20153625 21478865 10733574 11124027 15829977 10224118 17500032 15805579 22179700 15888456 15647825 11075811
THRA RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11018031 23331499 15604093 1331778 1314167 19422879 11117530 16189514
SKIL SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12764135 25609649 23331499 25059663 15761153 10531062 17510063 12793438 17469184 15231748
SMAD4 SPP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SPP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SPP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SUMO1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14514699 23331499 21071413 12813045 12740389
SNIP1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10887155
UBE2I SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 21988832 31515488 16189514 15637079 16713569 12621041 29892012 15231748
VDR SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20713445 7705332 20227497 23644099 7981122 8119880 16195230
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
SUMO1 TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 16763556 15959518 17060459 21284855 20504299 16189514 16524884 11889051 10961991
UBE2I TDG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15823533 18691969 21284855 15959518 11889051
TDG XPC â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 16713580 17129768 17855402 17884153 18199748 18543256 19809470 19847258 20211143
TDG XPC â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 16713580 17129768 17855402 17884153 18199748 18543256 19809470 19847258 20211143
UBE2I TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18512959 24753249 18691969
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 XPC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12771027 22336944 12242345 23050045 16357511 12967652 15927209
TP53 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12771027 9346961 10779360 21340684 19004803 10367887 20066118 12496474 12242345 20457558 20182602 10962562 6396087 9892649 12967652
TP53 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11238924 18431400 21508668 9891077
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP63 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16462763 22521434 17716971 19622632
NHEJ1 LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.0 1.0 PKG 28854368
TDG FGF2 â—¼   KO_UP_REGULATES ✅ + 1.02 1.02 PKG 28854368
XRCC4 LIMD2 â—¼   KO_UP_REGULATES ✅ + 1.04 1.04 PKG 28854368
TP53 FLNC â—¼   KO_UP_REGULATES ✅ + 1.04 1.04 PKG 28854368
XRCC4 HMGCS1 â—¼   KO_UP_REGULATES ✅ + 1.05 1.05 PKG 28854368
XRCC4 CDH2 â—¼   KO_UP_REGULATES ✅ + 1.06 1.06 PKG 28854368
XRCC4 FADS2 â—¼   KO_UP_REGULATES ✅ + 1.07 1.07 PKG 28854368
XRCC4 SLC20A1 â—¼   KO_UP_REGULATES ✅ + 1.07 1.07 PKG 28854368
NHEJ1 AHNAK â—¼   KO_UP_REGULATES ✅ + 1.07 1.07 PKG 28854368
NHEJ1 REEP6 â—¼   KO_DOWN_REGULATES ✅ - -1.09 1.08 PKG 28854368
XPC LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.08 1.08 PKG 28854368
TDG DNASE2 â—¼   KO_DOWN_REGULATES ✅ - -1.1 1.09 PKG 28854368
XPC MT1G â—¼   KO_UP_REGULATES ✅ + 1.1 1.1 PKG 28854368
NHEJ1 PDCD4 â—¼   KO_DOWN_REGULATES ✅ - -1.11 1.1 PKG 28854368
TP53 FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.12 1.11 PKG 28854368
TDG ANXA3 â—¼   KO_UP_REGULATES ✅ + 1.13 1.13 PKG 28854368
XRCC4 SCD â—¼   KO_UP_REGULATES ✅ + 1.16 1.16 PKG 28854368
XRCC4 RPL22L1 â—¼   KO_UP_REGULATES ✅ + 1.17 1.17 PKG 28854368
NHEJ1 MRFAP1 â—¼   KO_UP_REGULATES ✅ + 1.18 1.18 PKG 28854368
TDG SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -1.19 1.18 PKG 28854368
TDG TWSG1 â—¼   KO_UP_REGULATES ✅ + 1.18 1.18 PKG 28854368
XPC MT1E â—¼   KO_UP_REGULATES ✅ + 1.19 1.19 PKG 28854368
TDG AHNAK â—¼   KO_UP_REGULATES ✅ + 1.2 1.2 PKG 28854368
XRCC4 CBR3 â—¼   KO_DOWN_REGULATES ✅ - -1.23 1.22 PKG 28854368
TDG PDCD4 â—¼   KO_DOWN_REGULATES ✅ - -1.24 1.23 PKG 28854368
TDG YBX2 â—¼   KO_DOWN_REGULATES ✅ - -1.26 1.25 PKG 28854368
TDG HMGCS1 â—¼   KO_UP_REGULATES ✅ + 1.25 1.25 PKG 28854368
SETX CAV1 â—¼   KO_DOWN_REGULATES ✅ - -1.27 1.26 PKG 28854368
TDG REEP6 â—¼   KO_DOWN_REGULATES ✅ - -1.27 1.26 PKG 28854368
XRCC4 TDG â—¼   KO_UP_REGULATES ✅ + 1.27 1.27 PKG 28854368
ERCC5 SLC16A3 â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
TDG RPL22L1 â—¼   KO_UP_REGULATES ✅ + 1.33 1.33 PKG 28854368
ERCC5 FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.36 1.35 PKG 28854368
TDG CAV1 â—¼   KO_UP_REGULATES ✅ + 1.37 1.37 PKG 28854368
ERCC5 TF â—¼   KO_DOWN_REGULATES ✅ - -1.39 1.38 PKG 28854368
TDG PRNP â—¼   KO_UP_REGULATES ✅ + 1.39 1.39 PKG 28854368
ERCC5 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
TDG FADS2 â—¼   KO_UP_REGULATES ✅ + 1.44 1.44 PKG 28854368
TDG TAGLN â—¼   KO_UP_REGULATES ✅ + 1.44 1.44 PKG 28854368
TDG SLC20A1 â—¼   KO_UP_REGULATES ✅ + 1.45 1.45 PKG 28854368
XRCC4 CFDP1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368
TDG SERPINB9 â—¼   KO_UP_REGULATES ✅ + 1.48 1.48 PKG 28854368
TDG NES â—¼   KO_UP_REGULATES ✅ + 1.48 1.48 PKG 28854368
XRCC4 SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -1.51 1.5 PKG 28854368
NHEJ1 FGF2 â—¼   KO_UP_REGULATES ✅ + 1.54 1.54 PKG 28854368
XRCC4 PDCD4 â—¼   KO_DOWN_REGULATES ✅ - -1.6 1.59 PKG 28854368
SETX LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.61 1.6 PKG 28854368
TDG FAM111B â—¼   KO_UP_REGULATES ✅ + 1.6 1.6 PKG 28854368
NHEJ1 SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -1.62 1.61 PKG 28854368
NHEJ1 TAGLN â—¼   KO_UP_REGULATES ✅ + 1.62 1.62 PKG 28854368
NHEJ1 PCNA â—¼   KO_DOWN_REGULATES ✅ - -1.66 1.65 PKG 28854368
TDG CDC6 â—¼   KO_UP_REGULATES ✅ + 1.65 1.65 PKG 28854368
NHEJ1 NES â—¼   KO_UP_REGULATES ✅ + 1.67 1.67 PKG 28854368
NHEJ1 CDC6 â—¼   KO_UP_REGULATES ✅ + 1.68 1.68 PKG 28854368
ERCC5 ERCC5 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
SETX FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.71 1.7 PKG 28854368
TDG SPP1 â—¼   KO_UP_REGULATES ✅ + 1.74 1.74 PKG 28854368
NHEJ1 VIM â—¼   KO_UP_REGULATES ✅ + 1.75 1.75 PKG 28854368
TDG FLNC â—¼   KO_UP_REGULATES ✅ + 1.76 1.76 PKG 28854368
TDG LCP1 â—¼   KO_UP_REGULATES ✅ + 1.78 1.78 PKG 28854368
SETX TF â—¼   KO_DOWN_REGULATES ✅ - -1.86 1.85 PKG 28854368
SETX ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -1.87 1.86 PKG 28854368
NHEJ1 FLNC â—¼   KO_UP_REGULATES ✅ + 1.89 1.89 PKG 28854368
XRCC4 FGF2 â—¼   KO_UP_REGULATES ✅ + 1.99 1.99 PKG 28854368
TDG ANXA1 â—¼   KO_UP_REGULATES ✅ + 2.01 2.01 PKG 28854368
TDG PURA â—¼   KO_DOWN_REGULATES ✅ - -2.12 2.11 PKG 28854368
TDG LIPA â—¼   KO_UP_REGULATES ✅ + 2.14 2.14 PKG 28854368
NHEJ1 ANXA1 â—¼   KO_UP_REGULATES ✅ + 2.18 2.18 PKG 28854368
NHEJ1 SPP1 â—¼   KO_UP_REGULATES ✅ + 2.25 2.25 PKG 28854368
TP53 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -2.28 2.27 PKG 28854368
SETX SPP1 â—¼   KO_DOWN_REGULATES ✅ - -2.44 2.43 PKG 28854368
TDG VIM â—¼   KO_UP_REGULATES ✅ + 2.48 2.48 PKG 28854368
XRCC4 CDC6 â—¼   KO_UP_REGULATES ✅ + 2.56 2.56 PKG 28854368
TDG GSDMD â—¼   KO_DOWN_REGULATES ✅ - -2.61 2.6 PKG 28854368
TDG MT1G â—¼   KO_UP_REGULATES ✅ + 2.68 2.68 PKG 28854368
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
XRCC4 SPP1 â—¼   KO_UP_REGULATES ✅ + 3.34 3.34 PKG 28854368
TDG MT1E â—¼   KO_UP_REGULATES ✅ + 3.35 3.35 PKG 28854368
TDG TDG â—¼   KO_DOWN_REGULATES ✅ - -3.98 3.97 PKG 28854368
XRCC4 XRCC4 â—¼   KO_DOWN_REGULATES ✅ - -6.32 6.31 PKG 28854368
NHEJ1 NHEJ1 â—¼   KO_DOWN_REGULATES ✅ - -6.47 6.46 PKG 28854368
SETX SETX â—¼   KO_DOWN_REGULATES ✅ - -8.56 8.55 PKG 28854368