Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
VPS28 SMN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TFRC ALB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8412643 23384347
MYC ALB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17006931 8076602
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
INS CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28601906 25748795
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
HIPK2 SUMO1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 5217735 15896780
UBC ICAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17174307 5219467
MYC INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799123 1917937
MYC TFRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10737792
PHYH PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMN1 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPIB SETX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SETX WDR61 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TDG SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218717 16763556
SUMO1 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20016603 25114211
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
TFRC TF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20404192 0914898107
UBE2I TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SETX ERGIC1 â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
SETX VPS28 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SETX RHG01 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
JIP1 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CS075 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
VMA5A SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NGN3 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SETMR SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SETX NDK8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
APBB1 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
BRCA1 CENPF â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26831064 29656893
SETX CD2AP â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PAK1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12374744 16452229
FZD10 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ICAM1 PAK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MYC TDG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 26496610
MYC SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
SETX PAK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PNKD SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
VIPR2 SETX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CMTD1 SETX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
HMMR BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22110403 25184681 26831064
ISLR CDC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ISLR SETX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
SUMO2 SETX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19471022 21252943 16524884 21693764
HIPK2 UBE2I â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
ESR1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15961505 31527615
FGF2 SDC4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 16982797
SETX ACAD10 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
TP53BP1 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
SETX LGALS3BP â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
SUMO2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21147198 20016594 20016603 22689573 21693764
SUMO2 CHD3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19471022 32786267 15383276 21252943 21900206 16169070 16713569 24018422
SETX CDKN1C â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
BRCA1 CLSPN â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15096610 22863316 16713569
SETX LGALS3 â—¼   KO_DOWN_REGULATES ✅ - -0.87 0.86 PKG 28854368
PIAS1 ESR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31527615 11117529 15666801
MYC UBC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
LGALS3 LGALS3BP â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
SETX SLC20A1 â—¼   KO_DOWN_REGULATES ✅ - -0.88 0.87 PKG 28854368
PIAS1 SUMO2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
SETX BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25699710 34112789 25184681 29656893
SETX PHYH â—¼   KO_UP_REGULATES ✅ + 0.88 0.88 PKG 28854368
BRCA1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
TDG ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12874288 16282588
SETX FRMD5 â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
APBB1 ANXA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11916966 9788437 20215511 30415952 16713569 12646176 14612409
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CAV1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23634843 11563984 22230296 19595769
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
MYC CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10918582 18444242 11258956
MYC CDC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10899308 17093053
ESR1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15961505 24119295 18404132
ESR1 TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12459033
TDG ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12874288 17129768
SUMO1 HIPK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16253240 14609633 10535925 21192925 15958389 15896780 24637324 21145359
MYC ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SLC4A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
SUMO2 PIAS1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22578841 19471022 19394292 20016603 16524884 21252943 18806873 19217413 21693764
TOPORS SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11842245 14516784 16524884
SETX CDC6 â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
SETX TFRC â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.91 PKG 28854368
PIAS1 SUMO1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
SETX CENPF â—¼   KO_DOWN_REGULATES ✅ - -0.92 0.91 PKG 28854368
SETX SLC4A2 â—¼   KO_DOWN_REGULATES ✅ - -0.92 0.91 PKG 28854368
SETX SEMA6A â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.92 PKG 28854368
CD2AP UBC â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
TDG TF â—¼   KO_UP_REGULATES ✅ + 0.93 0.93 PKG 28854368
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
SUMO2 TDG â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
SETX ICAM1 â—¼   KO_UP_REGULATES ✅ + 0.96 0.96 PKG 28854368
PIAS1 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SETX PAIP2 â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
SUMO1 TDG â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
TF TFRC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
SUMO1 UBA2 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
TDG PAIP2 â—¼   KO_UP_REGULATES ✅ + 0.98 0.98 PKG 28854368
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SETX CCDC8 â—¼   KO_DOWN_REGULATES ✅ - -1.0 0.99 PKG 28854368
BRCA1 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
SUMO2 UBE2I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
TDG LEFTY1 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
UBA2 UBE2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ESR1 APOA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11013347 18005483 9535920 17532863 23293065
CLSPN CDC6 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CLSPN CDC6 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CLSPN CDC6 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
ESR1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18234909 11522780 9869301 10428965 12761896
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20616010 20068169 16950141 21029304 19433249
PAK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18521086 26944939 16778166 18755239 21893191 15178330 19205871 29548483 26554417 27003261 24505617 16452229 15193262 19557173 15642175 12374744 19465939 17604944 25447917 20179234
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
FGF2 SDC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9556568 20382221 9012653 8621465 16982797 8609172
SUMO1 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21145359 15896780 10535925 14609633
MYC TFRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 3302722 12695333 14519204 16466700 20631077
PIAS1 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16524884 22578841 19217413 18806873 14609633 11583632
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
SUMO1 TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 16763556 15959518 17060459 21284855 20504299 16189514 16524884 11889051 10961991
UBE2I TDG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15823533 18691969 21284855 15959518 11889051
UBE2I TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18512959 24753249 18691969
TF TFRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 11027676 21788477 9546397 6270680 16271884 29302006 14691533 12210842 20404192 16354665 6268632
SETX SEPTIN3 â—¼   KO_UP_REGULATES ✅ + 1.0 1.0 PKG 28854368
TDG FGF2 â—¼   KO_UP_REGULATES ✅ + 1.02 1.02 PKG 28854368
SETX GCAT â—¼   KO_UP_REGULATES ✅ + 1.02 1.02 PKG 28854368
SETX HMMR â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
SETX ID1 â—¼   KO_DOWN_REGULATES ✅ - -1.06 1.05 PKG 28854368
SETX NDUFA4 â—¼   KO_DOWN_REGULATES ✅ - -1.07 1.06 PKG 28854368
SETX RAB4B â—¼   KO_UP_REGULATES ✅ + 1.08 1.08 PKG 28854368
SETX SDC4 â—¼   KO_DOWN_REGULATES ✅ - -1.11 1.1 PKG 28854368
SETX CLSPN â—¼   KO_DOWN_REGULATES ✅ - -1.11 1.1 PKG 28854368
SETX CDCA7 â—¼   KO_DOWN_REGULATES ✅ - -1.16 1.15 PKG 28854368
TP53BP1 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.21 1.21 PKG 28854368
SETX S100A6 â—¼   KO_DOWN_REGULATES ✅ - -1.23 1.22 PKG 28854368
SETX MCL1 â—¼   KO_DOWN_REGULATES ✅ - -1.25 1.24 PKG 28854368
SETX CAV1 â—¼   KO_DOWN_REGULATES ✅ - -1.27 1.26 PKG 28854368
SETX INS â—¼   KO_DOWN_REGULATES ✅ - -1.29 1.28 PKG 28854368
TP53BP1 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
SETX GYG1 â—¼   KO_UP_REGULATES ✅ + 1.3 1.3 PKG 28854368
TDG CAV1 â—¼   KO_UP_REGULATES ✅ + 1.37 1.37 PKG 28854368
SETX EEF2K â—¼   KO_DOWN_REGULATES ✅ - -1.39 1.38 PKG 28854368
SETX NODAL â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
TDG SLC20A1 â—¼   KO_UP_REGULATES ✅ + 1.45 1.45 PKG 28854368
SETX HPDL â—¼   KO_DOWN_REGULATES ✅ - -1.5 1.49 PKG 28854368
TP53BP1 SPP1 â—¼   KO_UP_REGULATES ✅ + 1.53 1.53 PKG 28854368
SETX LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.61 1.6 PKG 28854368
TDG CDC6 â—¼   KO_UP_REGULATES ✅ + 1.65 1.65 PKG 28854368
SETX FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.71 1.7 PKG 28854368
TDG SPP1 â—¼   KO_UP_REGULATES ✅ + 1.74 1.74 PKG 28854368
SETX VAT1L â—¼   KO_DOWN_REGULATES ✅ - -1.76 1.75 PKG 28854368
SETX TF â—¼   KO_DOWN_REGULATES ✅ - -1.86 1.85 PKG 28854368
SETX ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -1.87 1.86 PKG 28854368
TDG ANXA1 â—¼   KO_UP_REGULATES ✅ + 2.01 2.01 PKG 28854368
SETX SPP1 â—¼   KO_DOWN_REGULATES ✅ - -2.44 2.43 PKG 28854368
TDG TDG â—¼   KO_DOWN_REGULATES ✅ - -3.98 3.97 PKG 28854368
SETX SETX â—¼   KO_DOWN_REGULATES ✅ - -8.56 8.55 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368
SETX HIST1H1A â—¼   KO_DOWN_REGULATES ✅ - -10.52 10.51 PKG 28854368