Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
BCL2 MAPK8 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733859 5217553
NFKB1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704864 11313951
SOD1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15233914
BCL2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210690
ESR1 BLM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17268063
BRCC3 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19202061 0807485106
KPNA2 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9497340 6547667
BRCA1 KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221252 8955125
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
BRCA1 KRT5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16241993 19882246
MTA1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17922032
BRCA1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574597
BRCA1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12700228
CDKN2A MTA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1018389108 21555589
ESR1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 10851069
CDKN2A SUMO2 â—¼   COLOCALIZATION 2.0 0.8 intact 6541703 18259216
CHAF1A PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CHAF1A XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
HIPK2 DDX39B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
ZHX1 DDX39B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
SENP3 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7941484 19680224
EP300 HIPK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18695000 16917507
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
HIPK2 EP300 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16917507 5218981
EP300 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20428248
EP300 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 20089040
EP300 DUSP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20626350 18504304
ERCC4 XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
HIPK2 MEF2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23565059 1001527
UBC ICAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17174307 5219467
ICAM1 CDH5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18783313 26556953
MYC IPO7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22284678
MAPK14 MAP2K6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255949 5219578
MAP2K6 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8622669 7535770
LRRK2 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
MAP2K6 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32911434 16951197
MAP2K6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11460167 10882101
MAPK14 DUSP1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 20347885 8288600
PML MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15273249 16189514
MYC MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12808131 11983916
MYC TRIM63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
NR1H3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10890879 12551904
MYC PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19602047 11509615
MYC DUSP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14519204
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
MYB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082531
ELK3 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
MAPK8 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
LRRK2 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
NFE2L2 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23708697 24180671
AR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12933816
PIK3R1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7642542 16982329
PDGFB PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7691811 9739761
PTPN11 CAV1 â—¼   COLOCALIZATION 2.0 0.8 intact 12176037 6731969
PTPN11 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9405464 19706677
SUMO2 RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19956565 1000252
CHD3 RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAE1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAE1 NUP98 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17172455 0609582104
RAE1 NXF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10668806
RIF1 GSTM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SUMO2 RNF168 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
RNF8 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20385750
CHD3 SAFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
AR SAFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23893242
SAFB ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10707955
ESR1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21920899 23658738
SIRT1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21775285
SIRT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27776347 28583374
CASP8AP2 SP100 â—¼   COLOCALIZATION 2.0 0.8 intact 5219543 17245429
TRIM63 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18157088 6492033
SQSTM1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9762895
SQSTM1 SOD1 â—¼   COLOCALIZATION 2.0 0.8 intact 8141566 21252941
PECAM1 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
TP53BP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16945145
UBC WRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6603858 18588880
CAV1 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17502619 0611416104
NOS3 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17502619 0611416104
ACTB HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NCBP2 NCBP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
ELK3 NUP58 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ITGAV PECAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8838667 7542249
NFKB1 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15175554
MAP2K7 MAP3K7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219344 17110930
NR4A2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18550828 19721341
SP1 KLF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18353772
RARA NFE2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709483104 18048326
NFE2L2 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27211851 16339837
NFE2L2 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23637463 22547061
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
RAC2 NCF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213243 11090627
KPNB1 CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
ZMYM5 LRRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 C18orf25 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 ESRRG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
LRRK2 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
NOS3 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17502619 0611416104
AR CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24218937 20610535
SP1 KRT5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12024040
SP1 HDAC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16280357
SP1 RORA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14742449
SP1 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22469463 10954564
ALYREF AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18562279 0802533105
ATXN1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
AR MEF2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23598283 20610535
MEF2C CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24473123 18758483
HDAC4 MEF2C â—¼   COLOCALIZATION 2.0 0.8 intact 5215014 11792813
NFKB1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21334436
PRKCZ NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11684013 12881425
BMI1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6948569 19233177
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
PRKCZ MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667433 17646398
PRKCZ MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667433 17646398
ESRRG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17157980 15821111
RANBP2 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12032081
ZHX1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZCCHC12 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
HTT UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC SENP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7941484 19680224
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
NXF1 NUP153 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10668806 5212227
NXF1 NUP214 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10668806 5212227
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CTNNB1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15558022 16291872
RARA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10607566 23331499
VDR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11470825 23331499
CTNNB1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24291232 24482235
CTNNB1 NR4A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 21362399
ESR1 NOS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17921256 0704315104
ESR1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10432218 18414489
ESR1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489
ESR1 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20623181
MYB AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12096342 18945670
HNF4A AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474850 12466965
AR RORA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24119295 20610535
AR RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069693 20610535
AR DNM1L â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10454563 21724752
AR VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15805579 16425262
AR PIK3CB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23365759 20610535
POM121 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZHX1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
IPO8 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SUMO2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19041634
NR1H3 PRKAA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19125418 20395595
NR1H3 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17054913 22279938
RARA HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11585914
ZHX1 CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
NR3C1 TRIM63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18615595 18612045
NR4A2 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15591535
NR3C1 NR4A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15591535
BMPR1A BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10712517
ACIN1 PNN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MAP3K7 MAP2K6 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 21902831
NUP35 NUP98 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ALYREF NCBP1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
NUP153 NUP54 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
KPNA1 SOX2 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
SUMO2 RIF1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19471022 32786267 29234018 21252943 21693764
UBC SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5216530 12857745
HNF4A SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15651981 16713569 19115260
SUMO2 DNM1L â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 21693764 32786267 29128334 23524851
NUP205 NUP54 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
NR1H3 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25962847 33742100
EP300 KLF8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 20107328
ACTB ICAM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31536960 23463506
MYC IPO7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
LRRK2 MSH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
MYC SETX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC NXF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC NOP58 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC RIF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC RNPS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
LRRK2 RIF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 23075850
SUMO2 WRN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16524884 19471022
ESR1 GSTM3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23576398 31527615
BMI1 NCBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
LRRK2 SENP3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
CAV3 CAV1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BMI1 NCBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
BMI1 RNPS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
BMI1 CHD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
BMI1 SAP18 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
GSTT2 NMD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RAC2 RAC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SOX2 MTA1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21532573 23667531
SOX2 SALL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 21532573
KPNA1 NCBP2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
SIRT1 EP300 â—¼   DEACETYLATION ✅ - 0.83 0.83 Signor 19047049
SUMO2 SETX â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21693764 16524884 19471022 21252943
ACTB CAV1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17502619 28734243
SUMO2 ETV6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21693764 35140242 19471022 12626745
SUMO2 ZHX1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21693764 16524884 19471022 21252943
GSTM2 GSTM4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
NXF1 RANBP2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CAV1 NOS3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MSH2 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10783165 15064730
SUMO2 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21693764 16524884 16620772 19471022
HIPK2 PML â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
AKT1 MSH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
MYC ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11839798 29467282
GSTM3 GSTM2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 1530570 26186194 33961781
ESR1 HDAC4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19893013 16051668
NXT1 NXF1 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 23299939
HNF4A SUMO2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 35140242 22505616
HTT SQSTM1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
TP53BP1 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ANAPC2 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MAP2K7 MAPK9 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
BLM MYC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23750012 30415952 29467282
SUMO2 BRCA1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20016603 20016594 22689573 21693764 21147198
BRCA1 WRN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16714450 24709898 29656893
SENP3 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19680224 15632193 22684029
MEF2C EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21556048 9001254
USPL1 SUMO2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22878415 21988832
SUMO2 SOX6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 35140242 16442531
SUMO2 PIAS3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21693764 19217413 19471022 16524884
SUMO2 CHD3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21900206 19471022 15383276 16713569 32786267 21252943 16169070 24018422
BRCA1 WRN â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
RARA AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16417524 23693014
CDH5 CTNNB1 â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 5219258 17057644
ESR1 DNM1L â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19805454 21217774
ESR1 RARA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9717844 25303530 25604459
SOX2 CHD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23667531 28794006
KPNA3 ZCCHC12 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
AKT1 NOS3 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24379783
BRCA1 MSH2 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
ERCC4 MUS81 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
KPNA2 NUP153 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
MYC UBC â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
MYC IPO9 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17353931 17314511 29467282
SUMO2 PML â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17000644 16189514 23543742 28851805 19553342 21148299 22155184 24190887 20826694 21779164 22578841 17081986 21693764 24637324 15940266 20797634 9452416 19471022 16713569 25027693 21252943
RAD51 WRN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17118963 18562274
SUMO2 SP100 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17000644 32296183 19471022 21988832 16524884 25027693 21252943 21693764 17491593
ESR1 ACTB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31527615 20308691 19805454 21182203 21182205 20348541
GSTM3 GSTM4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 25416956 33961781 26186194
PHAX NCBP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29101316 26496610 24981860
CDH5 KDR â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
RBM8A NXF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11707413 11546874
NUP85 NUP98 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24981860 24927568 26344197 24315095
SENP3 SUMO2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19394292 25027693 16608850 11029585
MTA1 CHD3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12431981 24981860 17922035 28977666 9885572 26344197
BRCA1 MRE11A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NCBP2 PHAX â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GSTM2 GSTM4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PML RARA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRE FAM175A â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RNF168 TP53BP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NUP107 NUP35 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25084169 10783165 26831064 29656893
BLM RIF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20711169 23509288
SETX BRCA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29656893 34112789 25184681 25699710
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
EP300 MYB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20364308 11585920 29954426 15691758 35140242 10656693 25740244
EP300 VDR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32603375 15647825 20089040 21988832
EP300 RORA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9862959 16713569
MYB PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15194430 20802522
CAV1 NOS3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8910295 12852865 11425855 17502619
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
TNIP1 UBC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
RAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16331275 21217774
NCBP2 PHAX â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29395067 24981860 26382858 26496610
RBM8A PYM1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 24981860
GSTM2 GSTM1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 6500576 33961781 12192076
SAP18 RNPS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16537548 22388736 33961781 26344197 12665594
CDKN2A MYC â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
GSTM3 GSTM4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AKT1 NOS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
RANBP2 SUMO2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NUP107 NXF1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
DNM1L LRRK2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
UBC USP25 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RNPS1 SAP18 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
SLX4 EME1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19596236 19596235 32398829 31495888 19595721
EP300 HIPK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16917507 29170424
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
RARA PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11050004 1311253 16189514 16713569 16540467 10882117 17560333 18073335 10610177 12935927 20159610
RARA SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18270252 10361124 19401466 16713569
SENP2 SUMO2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19394292 17099700 25416956
NXF1 NUP98 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22334672 16713569 11551912 10668806 16314397 29395067 11073998
CTNNB1 AR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5216126 12588987
RBM8A RNPS1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 11707413 23084401
NXT1 NXF3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 16189514 25416956 34133714 33961781 19060904 11073998
HDAC4 MEF2C â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
KPNB1 NCBP2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
KPNA3 NCBP2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CAV1 CAV2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PNN RNPS1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CTNNB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17404573 16288908 12782598
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
BRE BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14636569 22990118 25184681 29656893
MYC BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12646176 11916966 16713569 20215511 9788437 30415952 14612409
RAD51 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 31009828 11498787 16713569 19766185 25659039 19369211 25499220 9774970 28319063 17302439 9008167 14636569 28976962 24085845 34408138 29656893
AKT1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21242970 10542266 20085797 19074868
BRCA1 MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11498787 16713569 10783165 15886699 16260778
BRCA1 BRCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19305427 17664283 19202061 22990118 25184681 14636569 25252691 29656893
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
BRE BRCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21282113 19261749 19261746 30755420 19261748 17353931 20656689 14636569 33961781 20032457 19615732
ZBTB33 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
EME1 MUS81 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19596236 28514442 16189514 25224045 27354282 24733841 25319828 21962513 29738624 19017809 33961781 28575661 14617801 12686547 12721304 17289582 19363487 18413719
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
EP300 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10801418 15342649
EP300 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11796223 11062529 9001254
RAD51 ERCC4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 14734547 17962301 18541667
MYC ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28628118 17314511 12584560 29467282 28205554 30415952
SLX4 MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19596235 22902628 31495888 32398829
SLX4 MUS81 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25416956 29850896 25224045 21516116 23623386 22902628 25533185 32296183 23033263 19596235 31495888 23093618 21240275 19596236 23994477 29892012 32398829 24012755 19595721
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC CASP8AP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10918582 18444242 11258956
MYC RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC NXT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
RAC2 PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7744773 8645157 11803464
AR PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22740037 12063252 20610535
SP1 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16814105 19464346 17376651
SP1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9819401 21360626 24728382 16713569
SP1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843607 20160399 23704280
SIRT1 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18203716 20428248
TDP2 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ITGAV KDR â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12820653 19267251 17030947
PIK3R2 PDGFB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFB PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
CAV1 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20462514 12529448 19923922
MAP3K7 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAP2K7 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15837794 8533096 16186825
NR1H3 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23686490 16484597 24438183
SP1 KLF8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18353772
RAC2 NCF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9624165 9642115 16189514 11090627
NCF2 PRKCZ â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
RANBP2 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9398662 10473610
LRRK2 DNM1L â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22228096 22639965 24282027 29541021 23813973
CAV2 CAV1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12414992 16189514 31980649 9361015 18081315 33961781 24013648 10212252
CAV1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11563984 23634843 22230296 19595769
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
SP1 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10919269 15664452 10845704
SP1 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22399227 20018729
SP1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7559553
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
SP1 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14561739 16452190 9295358
SP1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12039077 14962081 15249123
SP1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7541039
SP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632985 18850004
NR3C1 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18174358 24500711 27371733
AKT1 ZHX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HDAC4 MEF2C â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31040226 23752268 32296183 15743821 15964851 12709441 10523670 11504882 11792813 18332106 11486037 11279209
NFKB1 TNIP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 21988832 19695220 35140242 33961781 25609649
NFKB1 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9058597
PRKCZ NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24379783
PRKCZ MAPK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20538799 11158308
SENP1 SUMO2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20212317 22878415 32296183 16553580 17099698 17000875 21252943
AR SENP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25014244 17932034 19116244
AR CTNNB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
CTNNB1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12944908 25241761
DUSP1 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8626452 11359773
MAPK9 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAPK8 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAP2K4 MAPK10 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MTA1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16807247 31527615 12167865 12639951 11146623 18451880
ESR1 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15664452 17556531 12710998
AR NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24315100 15219414 20610535
MAP2K7 MAPK8 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
RARA MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
CHD3 HSD17B10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NR3C1 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17978169 24399729
MAP2K7 MAPK9 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAP2K7 MAPK10 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MYB GSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576818
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ERCC4 SLX4 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDH5 CTNNB1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EP300 MYB â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
DUSP1 MAPK14 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
NUP153 NXF1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
NUP107 NUP153 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
PRKCZ SQSTM1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PIK3R1 PTPN11 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
NUP214 NXF1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
KPNB1 RANBP2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CHD3 MTA1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ACIN1 SAP18 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
NXF3 NXT1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
MAP2K6 MAP3K7 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
MUS81 SLX4 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
KPNB1 KPNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17596301
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
MAP2K6 MAPK14 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
SQSTM1 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
MAP2K4 MAPK8 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
BLM MRE11A â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
KPNA3 KPNB1 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
NUP205 NUP98 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
KPNB1 NXF1 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
BLM MUS81 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
KPNB1 SNUPN â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RAC3 SOD1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RAC2 SOD1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
MRE11A TP53BP1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
HIPK2 MYB â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 15082531 16055500
NUP54 NUP98 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ALYREF DDX39B â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
KPNA1 KPNB1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
KPNB1 NUP98 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
PNN SAP18 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
BLM TP53BP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
NCBP2 NCBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24981860
NUP98 NXF1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
KPNB1 NUP153 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
ACIN1 RNPS1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SENP2 SUMO2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
BLM RAD51 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19671661 29523790 12606585 17984114 11309417 11278509 19956565 18562274 15064730
NCBP2 NCBP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 23665581 9933612 26382858 31467278 11545740 22365833 26496610 29395067 12374755 26264872 7478990 19668212 22939629 29997244 32814053 29101316 24981860 31448526 17190602 12434151 26344197
NXF1 NXT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11256625 16189514 25416956 16713569 17978099 11583626 23299939 16314397 33961781 29395067 11073998 26344197
MAP2K7 MAPK8 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
RNF168 UBC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
GSTM2 GSTM3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
BRCC3 BRE â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
NUP85 NUP98 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
UBC USP28 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
UBC USP7 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
KPNA2 NCBP1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
KPNA2 NCBP2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DDX19B NUP214 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
BLM RAD51 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
KPNA2 KPNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PECAM1 PTPN11 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NCBP2 RBM8A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SENP1 SUMO2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NUP107 NUP98 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
NUP98 RAE1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NCBP1 NCBP2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NXF1 NXT1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NUP107 NUP85 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NUP85 SEH1L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NUP98 SEH1L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NUP107 SEH1L â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
NFKB1 BCL2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11313951 11704864 21725609 23178297 23572150
MYC BCL2 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
NFKB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16254192 11567031 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 12032828 19233129 16022909 18761399 18987666 15934930 21224428 16453001
SP1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14660675 20435036 12032828 10542244 15713621
MYB BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22101269 23675407 20237898 17823980 20659323 10692454 9096387 11675351 12384144 16088151 9823328
MYC BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8036017 17404573 12695333 24167291 18809243 19201832 16316993 19649202
AR BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17655826 11567031 23160675 20610535
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MAPK14 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 29050237 16714293 19336399 11495898
MAPK8 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 12421819 26609913 17097560 16738310 21726807 10567572 21993018 29950132 20919655 22848813 15225643 19029119 9738012 18570871 9115213 12039864 11323415 15733859 18471544 15703383 23329792 10677502
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM WRN â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
BLM CHAF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15143166
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FAM175A â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 BRCC3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 BRCC3 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FAM175A â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
BRCA1 XPC â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
BRCA1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20160719 18851829 9000507 21407215
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
BRCA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11085509 16713569 11016951
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
BRCC3 FAM175A â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCC3 FAM175A â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCC3 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
MYC CDKN2A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
MYC CDKN2A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
WRN CDKN2A â—¼   DOWN_REGULATES ✅ - 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
BMI1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
MYC CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15361884 11593429 11507042 20023701 23342141 16537449 23277542 10914736 9212167 12835716 24177224 11062467 15199070 18762810 19786833 20551174 11360201 23722468
SP1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10649433 22025288 15067344 17370299 21830402 17225865 12134028 19115249 16239970
MYC CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15361884 9308237 10373560 17936558 12209154 12738781 17873522 11283613 21406394 9312026 15095404 17558397 20551172 19901969 19815509 10504341
BMI1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21383063 9308237 21678481 17936558 22796940 20818389 11283613 15640618 19404261 21685941
MSH2 EME1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MUS81 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 EME1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MUS81 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
PRKAA1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11020388 21940946 12379484 15006641 12590608
SIRT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15632193 19047049
SENP3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15632193 19680224
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19608861 29954426 18585056 15691758 10656693 25740244
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
SLX4 ERCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23994477 24012755 21240275 24726326 22902628 23093618 19595721 19596235 25538220 20658648 19596236 19595722
MAP3K7 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15082531
HIPK2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17081983 27689990 27308327 26539288 19015637
IFNG ICAM1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
RARA ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7647034 1355009 7914515
NFKB1 ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 10926553 15480988 9192770 7957928 11198351 19074768 9188493 16317091 17121934 18928584 15843586 22001597 9056676 18285351 16385502 10946302 20103608 10738944 15800027 22708120 9888295 11877286 17855547 10553096 10092659 9733827 11401521 11463837 9916895 20173029 10837365 12691701 16105834 12490396 16453001
TANK IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
NFKB1 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15265881 16982926 11877397
KPNA1 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11032817 26491019 10523667 26496610 9922449 9102465 17596301
MAP3K7 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
MAP3K7 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 16200688 17301840 18855897 15125833 24699077 17363905 18641653 21902831 24403530 23331499 20060931 21133840 21614932 21232017 12738796 23606331 18264787 10391247 21220427 18988627 16799562 12620219 14633987 19161412 22941947 11280761 15082531 26192618 14660645 24958845 20164171 11460167 16603398 21041997 15282297 11274345
MAP2K6 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 10480932 19901323 17081983 7914033 9362518 18767875 17322306 8622669 18855897 16342939 16497976 15592455 8974401 7997261 15735649 18291705 23331499 8626699 21071413 16083285 21614932 18452278 12738796 20068231 9808624 11727828 16189514 18988627 17255949 9790884 16153436 18669648 26538579 14970210 16282370 11242034 18691976 18088087 11304531 15972258 10781613 17192257 18586681 10734320 20551513 19651622 15212693 7592586 16157584 21402774 9582275 15674326 9528766 7693711 12758252 11309380 7750576 17255097 17016520 15659558 11274345 15735648
NCF2 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16778989 25877926 14530365 27558335
MAP2K4 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7914033 7535770 7839144 9808624 7693711 7716521 7997261 12788955 26538579
MAP3K7 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12589052 17965022 15692051 17947236
DUSP1 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19741200 11278799 27880917 23331499 7535770 8626452 9202001 11359773 20626350 20936779 25241761 18813292 20347885 12356755 18723442 17158101 12758252 15659558
MAPK14 ELK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11042694 9130707 17570479
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 21902831 9069290 23331499 9858528 9384584 10330143 9753748 10805738 16189514 18988627 26660426
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
MAPK14 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 25847991 12351702 28582465 31974640 20047289 22911818 19841061 12000743 15817653 20660302 17570479 22401993 17440046 17185395 24024586 19812390
MSH2 MUS81 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 MUS81 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
KLF8 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
MYB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18408764 19609274 8382794 1679531 1588953 1594249 9596659 11259163 8474446 2233716 16088151
HNF4A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12591729 23714368 19966299 15024077
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12747840 20940401
MYC RBM8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 18414489
USP28 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23389829 19680264 17558397
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MAPK9 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10551811 34160558 26235622 25893300 25438055 20140016 33928666 11243879
MTA1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
MAPK8 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 10551811 17081983 18767875 20068231 91332050 1651323 1748630 16713569 11243879 18669648 15210690
MAPK7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22046506 9461566
PIK3R1 ETV6 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19345670 9918857 19438505 23168613 27795560 31066629 17764812 11027663
KDR PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
PTPN11 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 11593409 18950707 15790353 23109003 16371368 17722974 22315502 16107703 9660791 9918857 8080844 9632795 10973965
CTNNB1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10477752 25241761 16219695 11716761
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
PIK3R1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10527852 16799564 19442713
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
MAPK7 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 28153789 26539288 23730625 23316480 20832753
PTPN11 IL1B â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 27557510 9751747
PTPN11 IFNG â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
PTPN11 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18950707 23109003 16371368 17722974 22315502 16107703 9660791 8080844 9632795 15790353
RAE1 NUP98 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19615732 26186194 18832153 35096974 16036565 10209021 15851029 17172455 24927547 20498086 21467841 888800000819
RNF8 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
TP53BP1 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
RIF1 RNF168 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
TP53BP1 RIF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15342490 23333305 29203878
RNF8 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18001824 18006705 19203579 19772495
SUMO2 SENP5 â—¼   CLEAVAGE ✅ 9.0 1.0 Reactome 16253240 16608850 15487983 16738315 16738331 12192048 11896061 17591783 14563852
MAPK8 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 29578371 17081983 19007248 23434668 21540183 22622703 17924679 18187866 24296261 18838864 19413330 20027304 21471201 19107194 16964243 18669648 15302935
NFE2L2 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23382044 19762340 17189831 20452972 24416372
SP1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9762895 12736330 17012241
TP53BP1 FAM175A â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
WRN BMI1 â—¼   UP_REGULATES ✅ + 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
PRKAA2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12740371
PRKAA1 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15342649 17919121 27303922
MAPK9 ELK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11042694
MAPK8 ELK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 11042694
SP1 ITGAV â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10504395 23319049 12136940 23345412
SP1 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22415074 11222751 15175554 11967988 8662647
SP1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19888537 14684628 15111490 12560084 19469899 21980525 16678129 18006642 9079666 12067897 21430706 16574784
ESR1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16574784 18006642
MAP3K7 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
MAP3K7 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 20615388 18692468 15980064
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
MAP3K7 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 17110930 17709393 25241761 9890973
MAP3K7 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 11477091 17301840 13130464 18855897 15125833 24699077 9278437 17363905 18641653 24403530 20060931 21133840 21614932 9891069 12738796 21232017 9851932 18264787 10391247 16799562 23109003 12620219 14633987 12709432 8177321 19161412 22941947 23681101 12556533 11280761 15082531 26192618 14660645 24958845 20164171 11460167 16603398 21041997 11274345
NFKB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12759422 21642544 21243522 9374532 10227974 16481345 17556653 19732956 21224476 14662860 12757742 18690006 17407192
SP1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24019072 17023546 12576336 8756632 18793716 9503023
CYBA NCF2 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA RAC2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11145705 1660188 18347018 11090627 10455184
CYBA NCF2 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
NFE2L2 NQO1 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759
NFE2L2 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18039655 21569840 21382013 23000247 20599494 20309604 19007787 18028974 20623181 8962164 21622983 21638050 22245129 22302369 12947090 16948474 11013233 22521774 22154326 11035254 14510636 21926171 22459801 23413426 15385560 15574414 17360324 22911891 19897490 15734732 23738042 24024136 12149651 22346778 21843634 16785233 21097520
NFE2L2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24466341 17640564 18588981 15655294 22951256
NFE2L2 SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22493435 24417315 22245129
NFE2L2 NQO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18535259 18241676
LRRK2 KPNB1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
NUP98 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9144189 25562883 9275187
NUP153 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 35044719 10749866
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
SP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15531587 10684646 23280667 21631282 17108117
SP1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12759366 19105596 15722551 18624763 12684688 9614091 10574932 10713142 15061658 12270858 15180995
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
SP1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740727 7585542 15831516 9626663
SP1 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19540905 15651981 23307400
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19733223 17409431 11872750
SP1 SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8921911 18586551 18608091 21056687 24946209 11724400 9867871
MAPK8 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28831131 22266860 18199680 19245816 25398907 17570479
PRKCZ SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23148884 16943418 18258854 19464346 27320013 17049555 20953893
NFKB1 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 8413223 17707233 11058167 12686724 16433741 18285351 8021507 9878621 14960579 10963848 9058643 15543947 20696864 8679226 11035101 15972680 20336759 18772363 10080875 17082635
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15911620 15998799 17570479 30680530 11707464
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16417524
AKT1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759249 20166139 11756412 10376603 11923280 12446767 16697215 11044445 20398329 18372248 11696579 16126727 16839566 15808505 20138985 20299462 10908731 20363286 11988487 11425855 20214616 23103584 11729179 16043647 17570479 12171920 25460366 27322328 11978735 15169778 11029403 25241761 19654415 10949026 18048761 11715018 12791703 24379783 18636226 9812896 23397142 17680028 10376602 12431978 10722653 20832730 18570873 25009123 17052453
AKT1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27997540 24291004
AKT1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19376078 16340011 16083285 26506913 27784766 24467442
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 ALYREF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18562279
AKT1 ATXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 15757972 15824120 17540008 34302818 24903464 29212253 33709453 12741986 17570479 21722762 29758256 23719381 20037628 23213356 12757707 24858692 20477910
HDAC4 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12709441 15743821 11279209 15964851 10523670 23752268 11792813 11504882 18332106 10737771
MAPK7 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11238956 9069290 20936779 25689862 23331499 22661957 21071413 9384584 9753748 12640115 16189514 18988627
NFKB1 SOD1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 15317858 21725609 23178297 23572150
NR3C1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8639160 17016446
NFKB1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14576180 15517885 20159994 12165860 16619263
NFKB1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17644577 18397880 14570928 17081374
TNIP1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21988832 25609649 14743216 19695220
NR3C1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16713569 8290595 16380507 7823959
PRKCZ MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962008 8702918 18667433 17646398
ESR1 ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12960079 18174157 20211987
SUMO2 SENP2 â—¼   CLEAVAGE ✅ 9.0 1.0 Reactome 16253240 16608850 15487983 16738315 16738331 12192048 11896061 17591783 14563852
SUMO2 SENP1 â—¼   CLEAVAGE ✅ 9.0 1.0 Reactome 16253240 16608850 15487983 16738315 16738331 12192048 11896061 17591783 14563852
AR UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17409431 20610535 17721441
NUP214 NXF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11551912 11073998 10668806 16713569 10228171
NUP153 NXF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10668806 16713569
NUP98 NXF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22334672 10668806 16713569
AR CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18535113 18673534 20610535 11916967
AR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 21741601 16713569 12799378 12944908 10809237 23331499 15060161 21071413 21885566 18988627 16428447 11916967 12588987 11792709 10987273 14593076 15256534 22187462
CDH5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18287330 17057644 12413882 20123964 23243000 21255999
MAPK9 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 19623618 18423204 25639486 22074626 19667122 18604449
NR3C1 DUSP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24418482 20858750 23572530 18682532 17513787
DUSP1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 9020184 18813292 8626452 9202001 11278799
SUMO2 NOP58 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 24782567 20797632 25114211 21647297 25218447 20797634
MAP2K4 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17143273 7600581 11489946 10748139 18855897 14699111 10791986 17761173 18083107 12788955 9305638 22730327 23331499 19534553 23047924 11062067 21614932 12738796 15998799 11389443 18988627 9733714 11847100 16153436 21900206 11242034 14523011 26370088 10499589 16076903 7992057 7600582 9860979 17192257 15755722 12133933 19369195 9841871 10385525 12354380 9448004 12624093 11274345 11099046
MAP2K4 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 17143273 10713157 11489946 7600581 8702918 17145710 13130464 23416355 10748139 8805275 18855897 10791986 9108083 19690332 95141073 18083107 9724739 12788955 9305638 23331499 19534553 15068801 7839144 10958661 21071413 23047924 11062067 21614932 9808624 12738796 15911620 15998799 9891069 11389443 18988627 9733714 11847100 18669648 16153436 10521444 15302099 16282370 11242034 14523011 12709432 26370088 9661668 10499589 7652575 16076903 7992057 16440308 7600582 17192257 9860979 15755722 12133933 16533805 19369195 9312068 9207092 10385525 12354380 12917261 8910292 9487126 9448004 10962008 12624093 11274345 11099046
MAP2K4 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 17143273 11489946 10748139 18408005 18855897 17761173 18083107 8974401 12788955 10715136 23331499 23047924 11062067 21614932 15911620 12738796 11389443 18988627 12624093 11847100 11242034 26370088 16076903 12133933 19651622 12354380 14523011 11274345
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 CAV2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12711000 12138116 18414489
ESR1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22052999 11029009 10690351 14742696 19914929
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
AR NUP214 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
NR3C1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
MAPK8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24424504 21512132 21820033 16282370
AR NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
ARRB2 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19782076 11090355 18408005 11356842
SENP3 SUMO2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19394292 11029585
MAP2K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 12821118 10713157 11489946 17145710 9362518 13130464 18855897 19690332 95141073 24975362 23331499 7839144 21071413 18362184 11062067 21614932 15911620 12738796 18436711 11389443 10506143 11242024 11847100 18669648 16153436 15725726 25241761 18691976 14523011 25284480 16076903 17192257 11390361 15755722 16533805 19369195 9312068 9207092 9733513 12758252 12624093 15212693 11274345
MAPK8 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10383391 15657432 21272161
MAPK8 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12351702 18337589 9482836 9199329 18669648
PRKAA1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12740371
PRKAA1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10376603 12446767 11729179 16043647 11696579 16126727 12791703 24379783 19131647 18303014
HNF1B HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10518495 8290348 11585914 16479257
MYB NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16263717 15044598 22516378
MAPK9 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12351702 18337589 9482836 9199329
MAPK10 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12351702 18337589 9482836 9199329
MAP2K7 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 11489946 9362518 18855897 23331499 9890973 11062067 21614932 12738796 11389443 11242024 12624093 11847100 16153436 16076903 17192257 15755722 19369195 19822663 14523011 11274345
MAP2K7 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 11489946 9362518 18855897 18083107 10715136 23331499 9890973 11062067 21614932 15911620 12738796 11389443 11242024 12624093 11847100 18691976 16076903 14523011 15212693 11274345