Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
IKZF3 ATP6V0D1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LAMTOR2 ATP6V0D1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 25567906 1257132
ATP6V0D1 IKZF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TP53 BAD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17000778 22869582
BAD CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15725726
STK11 CDC37 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 34591612
NOS3 CDC37 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
CDC37 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
GLI1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20647328
AKT1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
RB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671466 14527674
HNF4A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17885207
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
KPNA2 CDKN1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7993392 20551905
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
CHEK1 MDM4 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
CHEK1 RB1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17380128 5219804
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
NFE2L2 DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22691366 14978030
DDIT3 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18794136 19074988
PRKAA1 DDIT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27650555
EP300 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16374512 11433299
EP300 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11896584
NOS3 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRIM27 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
IKZF3 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PRPS1 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GOLGA2 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
FMR1 CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FOXO1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23002242 16100571
FOXO1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21149440 23430617
NR1I3 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18391971
FOXO1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25510553 19049975
PPP2R1A FOXO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20110348 8288835
FOXO3 PIK3C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11278373 18388194
FOXO3 TSC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20371605
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
FOXO3 SIRT1 â—¼   DEACETYLATION ✅ 2.0 0.8 Reactome 14976264 23665396
PRKAB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21329882 17711846
AR FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18391971
FOXO3 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16100571
FOXO3 G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16840535
FOXO4 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22412893
FOXO4 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17390079
RBPMS FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TSC22D4 FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FXR2 TLE5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 PHC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 L3MBTL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FXR2 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
NRF1 FXR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16886907
SP1 FXR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16886907
HSP90AA1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
CEBPB HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
CEBPB HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
HSP90AA1 RIPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14743216
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
PASK MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 21418524 8145255
YWHAE MDM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16511560 5218386
MDM4 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 19521340 7290688
MLST8 CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12533512 18046414
MTOR AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
AKT1 MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17611497 18954143
MTOR CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12533512 18046414
MTOR RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23993916 25679014
NUAK1 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
RRAGD RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20006481 18497260
RPTOR CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12533512 18046414
NR0B2 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375098
SIRT1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21775285
STAT3 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15677471 23874455
STAT3 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22218594
STAT3 NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15950906
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
STK11 SNRK â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5217549 15733851
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 PSMD11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17184779 5219502
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
TP53 PRKAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PRKAB2 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 SCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
VCP PPARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP SIK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ULK1 DYNLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20921139
CALM1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
AR CALM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16619263 20610535
SP1 CALM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9348238 10945244
CALM1 CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10770941 7642608
DYNLL2 AMBRA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20921139
KPNA2 SUN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7993392 20551905
PPARGC1A CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12533512 18046414
BECN1 PRPS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEBPB SCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17387171 20352127
TSC2 GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
TSC2 TSC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6547838 9580671
TGFB1 NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10362813
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
TSC1 AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
PPM1A AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10644691
PRKAG1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PRKAB2 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARA PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17275789 22033933
NR0B2 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18385139 16213225
SLC25A5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAE RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PIAS1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20711444
TSC1 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
RB1CC1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16043512
SP1 PHC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212972 10976766
SP1 SND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160072 17350600
SP1 HDAC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16280357
SP1 GATA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18195733 7858429
SP1 APRT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11870072 10976926
RB1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10850422 7732011
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
AKT1 NRF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16230352
PPP2R1B CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R1A CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
CEBPB HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23251594 22905241
CEBPB ACACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22738246 20637321
CEBPB MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9743233 22139077
CEBPB SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22355693
NOS3 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PASK PIAS1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 21418524 8145255
GAPDH PSMD11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
G3BP1 GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PRKACA GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GAPDH LAMTOR5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
GAPDH POU2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12887926
AR VPS52 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16949732
DNMT1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1375221 10417323
YWHAE HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10737771 5212359
AR INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 20417685
IKZF3 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GOLGA2 IKZF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PRKACA SIK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22462548 27478041
HDAC5 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23899560 22991226
PA2G4 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
AR PFKFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 20958264
LAMTOR2 ATP6V1B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 25567906 1257132
SND1 G3BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 7968760 20643132
SLC38A9 LAMTOR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25561175 25567906
RRAGC RRAGA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRIM27 DNMT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
DNMT1 PHC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
PRKAA1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28143904
HSP90AB1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21730179 1105160108
MLXIPL PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16936198 21282101
HNF4A AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474850 12466965
AR NR2C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17655826 20610535
AR HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 21125667
IKZF3 PRKAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
IKZF3 CRBN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24292623 1244917
NR2C2 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12169272 16157589
PRKAB1 PRKAA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6767403 18480843
PPM1A PRKAB1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PRKAB1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460634 21072212
PRKAB1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PRKAB2 PPM1A â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PRKAB2 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PPM1A PRKAA1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PRKAA1 ALDH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 30375985
PRKAA1 PRPS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 29074724
USF1 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19720831 21147283
RRAGD HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NR5A2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069850 10799577
PPARA LEP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15764598 21598253
PPARA NR1I3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20208394 17962186
RB1 GATA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000123 19513100
TRIM27 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15837424
SREBF1 INSIG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15073165
SREBF1 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15123650
PRKAG1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PRKAG2 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PRKAG3 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PHC2 L3MBTL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TRIM27 MAGEA11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HMGA1 LEP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259597 19633359
SREBF1 SND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29296233
NRF1 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12958173 18222924
PPM1A PRKAG2 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PPM1A PRKAG1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PPM1A PRKAG3 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 16943194 8549768
PPM1A PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20010958
MLST8 RRAGC â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MLST8 RRAGA â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
HNF4A PA2G4 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ATP6V0D1 ATP6V1B2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
EP300 FOXO1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
FOXO3 TP53 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
BRD4 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 32416067 20676058 24945803 30428346
DCLRE1C PRKAG1 â—¼   PHYSICAL_INTERACTION 809.0 0.81 STRING 36370105
MTOR STAT3 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10660304 24931163 23329839 15522880
HNF4A SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15651981 16713569 19115260
BRD4 FOXO3 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CALM1 EEF2K â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
CHEK1 RAD51 â—¼   PHOSPHORYLATION ✅ + 0.81 0.81 Signor 15665856
ULK1 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21855797 20562859
CFTR CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
G3BP1 FMR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29395067 26777405
AXIN1 PPM1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16751101 10644691
AXIN1 TSC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21653829 12511557
YWHAE HDAC4 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 8005698 11504882
G3BP1 CSDE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29395067 26777405
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
DCLRE1C PRKAB2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
AKT1 BAD â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 9346240
HSP90AA1 STK11 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
TSC2 MTOR â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 12271141
CDC37 RAF1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
SIRT1 EP300 â—¼   DEACETYLATION ✅ - 0.83 0.83 Signor 19047049
AKT1 FOXO4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10217147 16272144 15688030 11313479 11689711
FXR2 G3BP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29395067 26777405 24778252
MAPT MARK2 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
TSC1 RHEB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12820960 30514904
AKT1 CDKN1A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 31575057
CFTR HSPA4 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
RHEB TSC1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
RPTOR ULK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ATG14 ULK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MTOR STAT3 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FOXO3 YWHAE â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
ATP6V0D1 ATP6V1A â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SNAI1 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28296173 25314079 32494626
FOXO3 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19592618 25609649 11896584
ULK1 RPTOR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25686248 21795849 21460634 21460630
SP1 STAT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
AKT1 STK11 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
CEBPB SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16651265 12847250 12665574
CRBN IKZF3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24292623 24292625 30042095 26990986 24328678 27294876
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
FNIP2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
MTOR ULK1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 21460634
CALM1 CAMK2B â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
RHEB MTOR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18550814 16098514 16915281 15854902 33157014 15772076 15878852 25351248
RPTOR RRAGA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 18497260 31601708 23184942 21816923 26582740 33961781 26186194 31601764 33157014 25561175 24337580
SP1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17471507 24396070 21184768 16931573
SIK2 VCP â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
GLI1 CDK4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22094256 26603838
CALM1 CAMKK1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CEBPB EP300 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
PSMD11 VCP â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
AKT1 FOXO1 â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 21798082
AKT1 FOXO1 â—¼   RELOCALIZATION ✅ - 0.85 0.85 Signor 18423396
RPTOR RRAGD â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
RIPK3 CDC37 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14743216 21903422
CDK2 TP53 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24173284
EP300 FOXO1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15890677 24419059 25609649 18786403 11896584
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
SRPK2 FXR2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26167880 25416956 29395067 34133714 32707033
RPTOR RRAGC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25567906 21981924 18497260 31601708 21816923 25446900 31601764 25561175 24337580
YAP1 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24976009 29789528
CDK4 ASPM â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 26496610
ULK1 RB1CC1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 8428476 23392225
ATG13 RB1CC1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
AKT1 NOS3 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24379783
ATG101 ULK1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
BRD4 EP300 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
POU2F1 SP1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
AKT1 CDC37 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
HNF4A FOXO1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12519792 19740748
ULK1 MTOR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25686248 23524951 29321306 21460630
BECN1 AMBRA1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 23974797
SND1 G3BP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29395067 20643132
FOXO1 PRKACA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RB1 SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MAP1LC3A ULK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PRPS1 PRPS2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDKN1A STAT3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
DCLRE1C PRKAG2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HSPA4 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
HSP90AB1 MAPT â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PFKFB2 PRKACA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BAD RAF1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
AR MAGEA11 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CRBN IKZF3 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RAF1 RB1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
RAF1 CDC37 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 31980649 24189400 24292678 17979178 33961781 32707033 16611982 16335536
CDC37 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22504172 12176997 31980649 24869908
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
EP300 PPARA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9407140 10336495 18797151
AKT1 FOXO3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21621563 10102273 25241761 21775285
RRAGD RPTOR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26582740 24337580 18497260 22424946
BECN1 TSC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20562859 28628118 28205554
BECN1 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29669822 23112296 28628118 28205554
TSC1 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28628118 15342917 12167664 28205554
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AKT1 NOS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PRKAA1 PRKAG3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BECN1 ULK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
HSPA4 MAPT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ATP6V0C ATP6V0D1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 BAD â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
PNMA5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
HNF4A PPARGC1A â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC4 YWHAE â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HNF4A NR0B2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ATG13 ATG101 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8428476 23392225
ULK1 ATG13 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 27617292 32543267 32668203 23524951 25686248 33450483 20562859 25126726 29196462 18936157 19597335 21460634 23392225 26018823 33499712 32707033 27203176 33422265 30853401 21460630
AKT1 FOXO1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CDK4 HSP90AA1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RB1 RBBP7 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RPTOR RRAGB â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
DYNLL1 DYNLL2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
AKT1 TSC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12438239 12150915 15342917 12167664
RAF1 YWHAE â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HMGA1 SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20335021 12665574
PPP2R1A CFTR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
CFTR PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
HDAC5 YWHAE â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
SIK2 CRTC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15454081 29211348 22462548
RRAGA RRAGD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16189514 26582740 33961781 26186194 28716898 11073942 25561175 22424946
PRKAG1 PRKAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 18480843 6767403
NR0B2 HNF4A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16455805 11535594 20516075 28128295 16488887 15604093 10594021
NR2C2 HNF4A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 35140242 12522137
GATA1 TRIP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 25910212 35140242 33961781 26186194
CFTR VCP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
AMBRA1 BECN1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
MAPT MARK1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
RAD51 TP53 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
FMR1 FXR2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CDC37 MTOR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 STK11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25036637 14676191 20562859 12489981 21860411 33961781 14668798 32707033
CDC37 CDK4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23455922 28514442 8703009 21871133 25036637 11867521 9150368 24189400 17353931 24292678 8666233 33961781 24981860 26186194 32707033 27339980 21675959
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
CDK2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11598016 19450264
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
TUBA1A CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HSP90AB1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
ATP6V1A CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SIRT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23474493 15130752 21719763
AR CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 17522055 18687691
PRKAA1 CRY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21892142
CEBPB DDIT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12706815 20562859 33961781 20102225 1547942 8662954
FOXO3 DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18226221
EP300 CEBPB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28428115 9343424 14630807 12471036
EP300 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10801418 15342649
USF1 FMR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15175277 18782566 11058604
FOXO1 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16670091 12414908 17317207
FOXO3 PRKAA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24257750 22848740 17711846
FOXO4 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11896584 11313479 11689711
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MTOR RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16847060 26522726 12604610 19619545 26348909 33378666 20169205 24036451 18570873 24516643 19299511 34031390 22424946 22356909 25940091 12719976 22544753 23263282 12150926 12665511 18505677 17277771 17461779 22493283 19114562 18722121 21071439 18030348 19446321 12718876 12747827 24375676 22258093 16837165 21045808 16962653 18955708 17565979 12408816 15467718 23953116 27043084 23911927 17043309 31601708 21177249 21614075 21795849 16631613 20381137 21321085 23297343 23872070 16354680 19875983 25446900 29059166 24337580 16603397 16183647 34171383 15066126 24403073 25332233 17386266 19145465 25007995 16798736 26678875 15268862 20427287 30865892 16919458 25273559 15459249 18519641 18504440 12150925
MTOR AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 18566587 25792870 15718470 14970221 24670654 10910062 18505677 29567957 22337773 21177249 26293922 19299511 18566586 30639242 21045808 11438723 22084251 23872070 21343617 22307628
PRKAA1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14970221
NUAK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21317932
RHEB RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16631613 25446900 15854902 33157014 24337580
POU2F1 RPTOR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21060808
SP1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843607 20160399 23704280
NR0B2 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20185821 20375098 21081708
PRKAA1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19923321
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
STAT3 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18266962 12559950
SP1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22412893 23995788
TP53 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15059920 27692180
TP53 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15212714 20097177 18840615
TP53 NME1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12669312 16440314
TP53 SLC25A5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24076372 9671769 12080472
RB1CC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16061648 21775823
TP53 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17409411 18431400
TP53 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17409411 18431400
CALM1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
CALM1 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 3906654 3693353 11015200
RHEB TSC2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12869586 12820960 30514904 12842888 17077083 15854902 12771962
AR TSC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21036700 20610535
SREBF1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11875060 19048273 22031849
YWHAE RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8005785 11697890
AKT1 RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 25241761 28628118 10576742 19197339 19058874 28205554
RHEB RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16803888 19222999 9001246 15150271 15854902
PPARGC1A NRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 16314495 18046414 18048642
PPARGC1A NRF1 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 16314495 18046414 18048642
PPARGC1A NRF1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16314495 18046414 18048642
PPARGC1A PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21775429 10669761
NFE2L2 VPS52 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16426233 20887713 15655294
YWHAE GLI1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8009500 038232 19996099
AR TSC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21036700 20610535
SP1 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14561739 16452190 9295358
SP1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7541039
SP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632985 18850004
AKT1 TBC1D1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17995453 17274760
USF1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15208653
AR PIAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 18656483 10628744
PRKAA1 PIAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27256105
YWHAE GAPDH â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PRKAA1 GAPDH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18183946 26626483
PRKACA CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 32913128 10187789 15209507
PRKAA1 MLXIPL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11724780 21892142
AR NR5A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21273442 20610535 23689136
PRKAB1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11729179
BRSK2 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21918180
CAMK2B PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15980064
PRKAA1 PRPS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 29074724
PRKAA1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19217427
PRKAA1 HDAC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21892142
PRKAA1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23291169
PRKAA1 SYN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10880969
PRKAA1 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21478464
PRKAA1 MFF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26816379
MARK2 HDAC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16980613
HNF4A NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17317687 11741883 16479620
PPARA NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14751809 16842672 17105827
PPARA SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18037994 15665064 22100307
PPARA SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12730331 1273033 21540177
NR0B2 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11369442
SREBF1 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16787385 22735681
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 HSPA4 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SIRT1 FOXO3 â—¼   DEACETYLATION ✅ - 0.9 0.9 Signor 24003218
AKT1 MTOR â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ULK1 RB1CC1 â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 19597335
TSC1 RHEB â—¼   PHYSICAL_INTERACTION ✅ - 0.9 0.9 Signor 20006481
CDK4 HSP90AB1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ULK1 ATG13 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 19211835
PRKAB2 IKZF3 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 8153045 21516116
PRKAB2 PRKAG3 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
LAMTOR1 MTOR â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
LAMTOR4 MTOR â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGA RRAGB â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGD SLC38A9 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
LAMTOR5 MTOR â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
TSC2 RHEB â—¼   GTPASE_REACTION ✅ - 0.91 0.91 Signor 15340059
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
LAMTOR4 RRAGD â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
PRKAB1 PRKAG3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
ATP6V1A RRAGC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ATP6V1B2 RRAGC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
LAMTOR5 RRAGD â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
LEPR LEP â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 22405007 9786864 33961781 8608603
ATG14 PIK3C3 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V1A RRAGA â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V1B2 LAMTOR1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V0C ATP6V1B2 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
MTOR AKT1 â—¼   PHOSPHORYLATION ✅ + 0.92 0.92 Signor 21592956
EIF5B GNB2L1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
ULK1 ATG13 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 8428476 23392225
CDK4 CDC37 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
CDKN1B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5219242 17053782
CDK2 RB1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
PRKAA1 PRKAB1 â—¼   PHOSPHORYLATION ✅ + 0.93 0.93 Signor 17728241
ATP6V1B2 RRAGA â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PPARA PPARGC1A â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ATP6V0C ATP6V1A â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CDK4 RB1 â—¼   PHOSPHORYLATION ✅ - 0.93 0.93 Signor 9139732
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
HSP90AA1 RAF1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
NR5A2 PPARGC1A â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
MTOR RRAGA â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
FOXO3 SIRT1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
MTOR ULK1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
AKT1 FOXO1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10358075 25241761 10358014 16076959 31844113 18786403
LAMTOR3 LAMTOR2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
RRAGD RRAGB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18497260 33961781 28716898 11073942 20381137 24337580 22424946
RB1CC1 ULK1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
RHEB RPTOR â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RRAGB RRAGD â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
CDK2 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 17409098
CDK2 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 15964852
AKT1 BAD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15998799 10358075 25241761 11500364 9381178 11994280 23085457 15722337 19667065 15784622
TP53 MDM4 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7290688 19521340
TP53 MDM4 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7290688 19521340
RRAGC RRAGB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25567906 21981924 33961781 28716898 11073942 20381137 25561175 24337580 22980980 22424946
RRAGC RRAGA â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 25567906 21981924 16713569 31601708 21816923 23184942 33961781 26186194 33157014 11073942 28716898 20381137 25561175 24337580 25936802 22424946
PRPS1 PRPS2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 25416956 25910212 26496610 32814053 33961781 26186194 22939629
PRKAB1 PRKAG2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAB2 PRKAG2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAA1 PRKAG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
ATG13 ULK1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
CALM1 NOS2 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PRKAA1 PRKAB2 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CDKN1B CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 34591612
FXR2 FMR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32296183 25416956 16713569 7489725 26949739 21653829 8668200 24778252 10567518 30217970 33961781 24981860 24722188 29395067
TSC1 TSC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16464865 25263562 11290735 17077083 12511557 11741832 10807585 11175345 20166753 15342917 30514904 11741833 17658474 15963462 16339216 20169078 10585443 14551205 9580671 12167664 10915759 16424383 20412061 12869586 16636147 9809973 14651849 28561026 15851513 17693255 21134130 15340059 12176984 15851026
NR5A2 NR0B2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22504882 11668176 20516075 14963109 21566081 12198243 20375098 21262773
HAT1 RBBP7 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
RHEB TSC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PRKAA1 PRKAG1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
MTOR RRAGC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PRKAA1 PRKAB1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
NR0B2 NR5A2 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
MAPT PRKACA â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDKN1A CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16765349 5218735
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
RBBP7 HAT1 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 27705803 33961781 20953179 26186194 24981860 22939629 28143904 26344197
CALM1 NOS3 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CDC37 CDK4 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LAMTOR3 RPTOR â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
TSC1 TSC2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LAMTOR3 SLC38A9 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LAMTOR3 RRAGA â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CDK4 CDKN1B â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDK4 CDKN1A â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ATP6V1A ATP6V1B2 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ATG101 ATG13 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
PRKAB2 PRKAG1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
LAMTOR2 MTOR â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR2 RRAGB â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RRAGB SLC38A9 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR3 RRAGD â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR5 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR1 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR1 RRAGD â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR4 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR3 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PRKAB1 PRKAG1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MTOR RHEB â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG14 BECN1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDK4 RB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MLST8 MTOR â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RRAGB RRAGC â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RRAGA RRAGD â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CDK2 CDKN1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK2 CDKN1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM4 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR5 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPTOR RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR3 LAMTOR5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 LAMTOR5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR5 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR5 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR5 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR3 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGA SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR3 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGC SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MLST8 ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
ULK1 ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 15197469 19225151 21460630 18936157 27932573 19287211 19597335 27390127 27387056 27203176 25686248 26018823 20562859 23524951 33450483 26687599 19211835 23392225 26138443 25126726
MTOR ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12150925 18000759 19225151 21157483 17680028 19151919 19864431 26801615 15755954 19446321 19258318 19706736 12408816 19211837 11274345 19211835 19568798
ATG101 ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 20562859 23392225 26299944 19287211 24290141 19597335 24100292
ATG13 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20562859 19225151 23392225 19597335 19211835
AKT1 BAD â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
RAF1 BAD â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11532940 12107820 12566895 14764585 15516985 19289794 19565474 24027568 8929532 9069260
MAPK8 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 11983683 12189144 14673001 16166315 15526032 29795446 15907327 14967141 15725726 17555943
RAF1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 11983683 12444011 10880354 19030972 19667065 22096607 15849194 16931767 17535812 16103085 9381178 23162742 12107820 18402774 12767520 10826997 8929532 8929531 12175651 25241761 19565474 10949026 19165420 9069260 21540285 17242355 23397142 19289794
PRKACA BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 11983683 10880354 20166139 9346240 11493700 9381178 18794113 12931191 15280015 10230394 10558990 8929531 18669648 10837473 10837486 10611223 12954615 10949026 10851172 15123689 18707149 16403219 17270021
AKT1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 137.0 1.0 Omnipath 10880354 19052636 21506126 20028971 21303971 20214616 11994280 8929531 17570479 12832477 17555943 25241761 11715018 18636226 21998731 9812896 17680028 11500364 18385666 18707149 10201527 18218901 11983683 10490655 19030972 19667065 11756412 11020382 16931767 18372248 15808505 20138985 18046313 18669648 19121340 19703413 11714830 10949026 15972258 16341064 10358075 23085457 18220336 10516287 12897128 9580112 9651683 11923280 9346240 16697215 19690332 11493700 15452053 12040186 10826997 12175651 15722337 14737178 11882383 15226424 10521512 15023346 15784622 17052453 16044149 16403219 12444011 20166139 20398329 9381178 11544290 15037618 12767520 15280015 10230394 10558990 15998799 10082559 11577096 10837486 15169778 10611223 23109003 12954615 22094462 11438654 11312610 11254732 21540285 10383455 19664994 10722653 20832730 18570873 10926925 17270021
RB1 CDK2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 RB1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
CDK2 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12124936 19815529 15004009
CDK2 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21565170
CDK2 HMGA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17960875 17570479 21319273
CDK2 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17601773 22369944 17570479 20818427
CDK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 26581405 9315635 17303408 18692063 23437375 19413330 20871633 26148348 28806746 15279786 16326706 8626527 21902831 14627988 7575488 9190208 21697511 9139732 20068231 17570479 16189514 12006580 11420722 18669648 15811853 18590585 27507850 17380128 23160093 19638577 1756735 20418918 19262748 17660363 11777937 10499802 19651622 20058876 15173007 22263797 10207050 8756624 10542199 19664994 24466208
CDK2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 94.0 1.0 Omnipath 23443559 23455922 10878006 20100570 23602568 15964852 20839231 25416956 23737759 9840943 18850315 11302688 20519948 24358021 19440234 15557281 9472014 9658399 16962592 9736735 12949733 8641969 10022118 15890360 12839982 16765349 17418410 15647383 10874474 15232106 17570479 17698606 12361598 26496610 9632134 24419005 12417722 16189514 26186194 20587660 25241761 8622677 9660939 25483090 12800980 20102411 10918595 12058028 12144826 8242751 9464540 9858587 29899857 23007395 11477082 9218599 12383116 25463440 12730199 8756624 9284049 9380407 9546435 24218572 16964243 15212693 13678583
CDK2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21106439 19652536 7575488 18590585 17522590 17303408 27035875 19473886 24948874 15677884 15279786 23029264 19124971 17660363 17038621 20148668
CDK2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 125.0 1.0 Omnipath 26416244 20519948 19631451 16326706 17409098 15557281 9658399 23029392 22733130 17570479 26496610 23576547 12700233 9388487 10585280 27282251 27175940 15619620 25241761 15735731 9218599 9192873 17254966 15996662 9724724 11940657 18285702 22492278 23409140 18615582 12093740 22721951 15647383 9380407 17418410 16189514 17053782 17698606 25852190 10679394 17602833 9660939 12188931 15122251 10831586 25818643 22028818 21424700 12529437 15011833 12042314 11250701 11223033 23455922 8978686 16780593 21439954 15302935 19648963 14504289 9736735 10198259 16782892 11565035 21423803 16492801 9311993 12417722 17671428 21187893 15355997 28601655 10809788 10393546 15212693 10323868 26450989 23602568 18850315 12482975 9399644 15890360 9632134 17254967 26186194 20810788 20197382 15475007 12800980 17997402 12972555 15980415 24336329 26701207 25605247 26987798
CDK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 24173284 9315650 19413330 19664995 16083285 1088347 16552184 10884347 17570479 10747897 25241761 7624134 11687964 17287340 92065884 12064478 19556892 14640983 10348343 14702041
CDK2 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21765472 21965652 21907702 18983824 24242917
RB1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
NR0B2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14752053 11502738 17074765 19322021
FOXO3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18312651 18005957 16908841 20671123 21249150
FOXO1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17609436 23574718 23918930 24769335
CEBPB CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10982390 15466360 15041706
STAT3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23178160 19372587 15286705 18320073 15063116 16923815 9694869 22328012 12438313 11773079 20654581 10023678 19329556 21184768 11114718
DNMT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21229291 21572997 19056828 16276353 9588214 21868513 23658227
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
FOXO3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
AKT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11756412 11923280 16697215 20452955 27603133 20398329 18372248 15001356 15808505 10217147 19440234 20138985 12431783 10753973 17855660 19216069 28358423 20214616 11463845 9829964 17570479 17646672 16680151 11231573 15169778 12851486 31575057 25241761 23109003 21933447 10949026 16775416 23886938 26436589 16288292 11715018 16055744 18636226 15023346 9812896 12042314 17680028 24848107 16982699 11779850 10722653 20832730 18570873 20307683 34069970 17052453 15798220
MAPK8 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12730199 15964852 17325029 19664994 12058028 11779850 17570479 20519948 16964243 18669648
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
FOXO1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
HDAC4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18632985 18850004
CDKN1A STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25241761 16189514 10764767
CDKN1A RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 10498883 9315635 17303408 10486249 16236519 11520855 15279786 9190208 7575488 10385618 9736735 7736585 19075565 18590585 20068082 9425340 18786381 17660363 10778858 17556661
CDKN1A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23443559 15169570 18850315 9658399 16962592 15232106 9632134 16189514 8622677 15695403 20102411 8242751 9464540 23007395 7626805 9106657 12383116 30193583 17556661 23543736 8756624
RB1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
FOXO3 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 21840777 19244250 19911116 17522055 18312651 21752881 22930444 18393360 10783894 15100294 11094066 18593906 18687691 19168439 21249150 14981546 18787071
TP53 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15145945 15988033 19235838 10516009 21478095 14984207 19427386
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
FOXO1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21418583 17015685 12359217 12391153 11094066 18593906 19281796 18787071 23160481
FOXO4 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11689711 15688030 15905404 10783894 12964026 20570964
FOXO1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11073996 19380174 10783894 20673124 11094066 15668399 17646672 21708191 15084260 21613825 17940099 11994454 11154281
PRKAA1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 33755959 14504289 12042314 21423803 19672859 23707388 30033086 17053782 17237771 24336329 26307683
TP53 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21340684 20066118 20457558 20182602 6396087
YWHAE CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14504289 16189514 12042314
FOXO3 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 14976264 19564415 18644865 19380174 10783894 16288288 20673124 11094066 15930121 21708191 17646672 15084260 15509806 21613825 17940099 11994454 11154281
FOXO4 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10783894 12391153 11313479 20673124 11094066 17646672 15509806 10217147 11994454
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
CDKN1B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 23602568 8978686 23707388 21439954 18850315 16326706 9658399 14597415 18615582 10198259 16782892 9632134 16189514 17053782 11360184 9311993 17092340 20837141 26186194 25241761 15695403 9464540 19470470 9106657 10908655 23543736 11940657 18285702
CHEK1 FANCG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 18931676 19686080 19793801
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
AKT1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20832017 18691976 23108403 17418864 20068231 12062056 15107605 17570479 19664995 18669648 26091525
CHEK1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 26610585 27685627 18285803 22730303 18317453 22705496 29977027 19473886 22665067 25852742 25909291 24847116 24204313 15665856 24238855
CHEK1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 16163388 16511572 18356162 17110929
CHEK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17380128
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
CHEK1 FANCG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17296725 19686080 18677104 15798197 17102137 17116885 17582221 19793801 17384638 18931676 15459660
CEBPB DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8051100 16757577 10085237 8662954
DDIT3 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23667408 22905241 10218478 22802018 10472808 20801537
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
PRKAA1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11020388 21940946 12379484 15006641 12590608
SIRT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15632193 19047049
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
NRF1 FMR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16886907 9302255 9328468 11058604 15175277 24250222 18782566 16500891
SP1 FMR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10612627 16886907 9328468 15479157 15175277 16500891
FOXO1 PPARGC1A â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 10364186 15668399 16122419 19449109 25464856
FOXO1 PPARGC1A â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 10364186 15668399 16122419 19449109 25464856
AKT1 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 FOXO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19244250 16100571 18202312 23509296 19690465
FOXO1 TXNIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23803610 18301748 24112473 19690465
FOXO1 G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15047713 12130586 22296760 22384829 12373635 16308421 10960473 21081708 16492665 22521266 16804074 23995837 12556524 11467835 12507516 18805788 16037130 20577053
FOXO1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24478438 16492665 18202130 20868688 22511764
SIRT1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 24003218 22013015 14976264 18235501 15220471 14980222 22395773 15788402 15692560
CEBPB FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18391971 11893744
PPARA FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16985262 18391971
AR FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18391971 17202144 16713569 12482965
AKT1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 21440011 10358014 11756412 10358076 31308176 20452955 21798082 11410590 20398329 11311120 11544290 28279977 10217147 15132996 23331499 19216069 11237865 20214616 11463845 16076959 11030146 12228231 9829964 18951090 23180781 17570479 10102273 18593906 17646672 16680151 12456685 18423396 18985696 18988627 17962350 30728292 16670091 18786403 14664696 25241761 16341064 11980723 10358075 2984676 13679577 12560069 10377430 11251083 17680028 2987962 17254970 11864996 20041807
HNF4A FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12519792 19740748
FOXO1 G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16840535 11672436 11467835
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23525956 20816089 15604409 23262029
FOXO3 TXNIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20656682 19690465 18226221
FOXO3 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22412893 22848740
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
FOXO3 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16061480 17522055 18687691
PRKAA1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17900900 17711846 22848740 29445193
SIRT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 24003218 14976264 14980222 15126506 21713995 15917664
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
AKT1 FOXO4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
MAPK8 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11689711 20959475 17570479 15538382 15212693
SIRT1 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15126506 10102273
AKT1 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 58.0 1.0 Omnipath 11756412 20452955 21798082 20398329 15538382 10217147 23331499 19216069 20214616 11463845 23180781 9829964 11313479 10102273 10518537 14690436 16680151 17646672 18988627 17522590 11896584 16272144 11689711 17680028 21620960 19664994 11864996
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
PPARA HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12482853 12962497
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
HSP90AA1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 25036637 19011619 16093354 8962087 18266962 8408024 23118896 22939624 24462205 16189514 17699868 20039095 16504566 20159553 17409432 16330544 15618521
HSP90AA1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12124224 11988487 11425855 11744239 9580552 12676772
MARK2 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 7706316 28066266 9108484 23666762 23001711 17360912 17573348 21311567 22952452 24251416
MAPK8 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 34342183 17314187 33557920 15312816 17761554 33762974 33842885 12614922 15136685 17270732 15228592 28758999 34385305 8506352 15994305
PRKACA MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 9614189 9832145 19562805 12387894 9546672 19413330 1730702 7706316 9353289 20068231 16923168 21215781 8999860 9565682 11181841 10737616 7566346 12435421 17287340 9771888 19651622 9735171 11104762 12226093 16000144 8163474 26840030 6412713 9199504 10090741 11311121 2387894
MARK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 62.0 1.0 Omnipath 33649324 9832145 18949077 12387894 23666762 25918155 19413330 21776376 30734106 7706316 27023670 16443603 21215781 20706749 19451179 8999860 15822905 16606369 7931292 10737616 19967412 12435421 9771888 34560101 9735171 21985311 8318230 33895139 26858248 8631898 23583109 10090741
BRSK2 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17482548 21985311 27768972 15705853 23583109
TP53 MDM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16492744 18172009 21750655 20036872 21422812 17510313 9926934 18336191 19521340 20372076 10469568 20080970 22290440 21394211 23474762
AKT1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16163388 18356162 16511560
MDM4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 25609649 18677113 28487147 24445145 30045945 20515689 26148237 22266850 11528400 19521340 21088494 16713569 15916963 9226370 12874296 21925390 16024788 25825738 24667498 16227609 24127580 8895579 20174603 18485870 12963717 15604276 25464845 12370303 10608892 23028042 25961923 26186194 17110929 22374672 26876197 17301054 23671280 21965653 17875722 22807444 10075736 19305137 17080083 29023092 27114532 20724842 10827196 19255450 24659749 28035068 23946421 20705607 19075013 21075307 12393902 11223036
MTOR MLST8 â—¼   PHYSICAL_INTERACTION 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MLST8 â—¼   SHARES_COMPLEX 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MLST8 â—¼   ENZYMATIC_REACTION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
AKT1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
MLST8 RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MLST8 NRF1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR MLST8 â—¼   LOCALISATION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MLST8 â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RHEB MLST8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17604271 15854902 19299511 16636147 12718876 15878852 17470430 19143635 12906785 18466115
MLST8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19203586 15718470 19568798 15169778 19720745 17517883 18925875 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR NRF1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
RHEB MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18670866 18075516 18550814 16631613 18466115 16915281 23331499 15772076 16098514 20006481 15878852 21071413 23272152 19299511 15854902 19487463 20226003 19143635 17604271 16636147 17470430 12906785
MTOR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 29228628 10660304 22408571 12796477 16740698 18691976 26573296 15522880 27384580 26775702 24423131 26241748 23055980
MTOR ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 18000759 19225151 21157483 25759175 15755954 28464882 19446321 27681874 26417067 28518135 19706736 24119841 27325266 26906453 27731364 29686608 25026281 27935582 28366635 28674405 27617292 26869683 29507183 25679763 28389629 25686248 19568798 27387347 21383122 26118643 32134989 26887051 12150925 29540819 29849901 10995454 23136410 30093610 19864431 24358342 26844203 29787772 30127742 19690328 21460634 26447757 26589724 21258367 22770472 29057166 29752434 29066806 17680028 19151919 24998849 30174616 26734992 17595159 12408816 11274345
MTOR AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 24670654 16697215 11438723 21592956 20398329 17461779 18372248 21177249 21045808 20338997 15808505 16221682 20138985 20489726 15899889 20214616 8978681 21474067 14970221 19203586 17660512 15718470 19568798 20333297 23006971 15169778 25241761 18566586 19720745 17517883 18925875 22084251 10949026 14761976 11715018 19143635 17277771 18636226 10910062 15047712 9812896 18505677 21343617 19844585 17680028 19151919 18566587 9736715 23872070 10722653 20832730 18570873 17013611 17052453 12408816 15364915 11274345
AKT1 NUAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15060171 12919958 12409306
STK11 NUAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14976552 19369195 21317932 20354225 16488889 29566768
TP53 RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17513613 16322760 20802511 16398215 18769160
TP53 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 8617246 11002423 16713569 16322760 16983346 9380510
RPTOR RRAGA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RPTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
AKT1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
RPTOR NRF1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RHEB RPTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RRAGC RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21816923 25561175 20006481 18497260 24337580 25446900 21981924
PRKAA1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21460634 18439900
RHEB RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17604271 15854902 19299511 16636147 24337580 15878852 17470430 19143635 16631613 12906785 18466115 25446900
PRKAB1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18220336 19369195 21460634 18722121 18439900 19413330 18669648
AKT1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 18000759 21157483 11756412 11923280 16697215 20398329 17461779 18372248 15808505 20138985 20214616 19568798 15169778 19720745 17517883 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
SIRT1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15205477 15744310 15989956 18687677 19590512 19960022
SIRT1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15205477 15744310 15989956 18687677 19590512 19960022
SIRT1 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23142079 21633182 19553684
MAPK8 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 29578371 17081983 19007248 23434668 21540183 22622703 17924679 18187866 24296261 18838864 19413330 20027304 21471201 19107194 16964243 18669648 15302935
SIRT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15744310 20640476 24003218 19553684
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
GLI1 SNAI1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
STAT3 CEBPB â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15240880 19233843 16226915 19913854 15913829
STAT3 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21611796 19754268 19118090 16887796
MAPK8 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 23255093 17502367 21702955 19413330 11335711 9343414 23331499 15465816 12576423 11350938 20068231 12763138 9872331 18491316 18669648 10521505 18691976 20058876 15979846 14551213 10446219
LEP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19774101 22000926 25594176 12049654 26000480 24410832 27050378 22359610 28750624 15581426 26636769
LEPR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11018044 21166956 8608603 18718905 11445068
CEBPB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11134330 18266962
STAT3 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15870198 16861352 25854163
PRKAA1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
PRKAG1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
PRKAB2 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
PRKACA STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11853558 17482548 11297520 17482549 10642527
STK11 MARK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 17192257 14676191 14976552
STK11 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 PRKAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 BRSK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23629625 18339622 14976552 16870137
STK11 PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8910387 15509864 15661536 20160076 19197243
STK11 MARK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 14976552 19369195 28711359 22238344 17573348 17192257
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
STK11 MARK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 14517247 18691976 14976552
STK11 SNRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15733851
STK11 PRKAG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 16434556 25792737 14985505 14976552 20489196 21062936 20656472 20616029 17255104 16041368 25696921 21399626 12391032 20160076 17244528 15980064 17054914 22517326 14532170 21918180 28694351 18693249 26771234 20801214 16600998 18195011 28723898 16912160 22039048 26068970 14614828 19884317 25679763 22575644 19197243 27864418 30022161 25683918 18303014 17287464 15327994 12764152 16054095 15509864 26506235 14511394 27181208 28625738 25874865 8910387 17276402 26247630 21680840 19414597 23418352 24289924 15383373
STK11 NUAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18083107 14976552 17242355
STK11 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 SIK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14976552 23322770
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
TP53 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11818510 16895524
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
TP53 NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11131279 11092782 9194524 8637893
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
PRKAA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28797070 15866171
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
VCP NFE2L2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
AKT1 VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16551632 19335618 16027165
AKT1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 27979972 25360797 26804165 28273460 25751140 24101154 25751139 34052254 25362852 28114269 28793266 26265440 31239271 25601544 28474680 33630828 26119935 27144834 27425596 25531778 34206989 34465890 21945154 25195862 31792377 18640976 28775168 32015438 32523092 22234184 33536280 33622361 30600590 24362629 34155345 24658687 21060948 33162394 20153295 26668327 21730131 26549256 21666719 25605730 26039999 34226698 20823509 34516278 27033705 32064037 32271880 32513743 33990468 24812269 32053631 32929029 34058200 25772246 26364602 27765911 26678338 27979971 33552953 28171658 34129887 21376238 28416665 25998128 25109332 12535517 31988076 26933062 26598551 25373897
DYNLL1 AMBRA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 27173435 20921139
INSR CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 17389395 19901323 18578522 12153558 18707149 20068231 16497976 17287340 3415247 2843348 8639568 17016520 18669648
CALM1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10908731 19358819 10376602 10376603 20705923 22486744 12171920 16839566 24379783 11397791 11978735
CALM1 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9822657 11395482 10187789
PRKAA1 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15342649 17919121 27303922
NRF1 CYCS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17099248 2166701 12533512 17273866 16908542 24250222
BECN1 PIK3C3 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 PIK3R4 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 ATG14 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 PIK3R4 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 PIK3C3 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 ATG14 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
AMBRA1 BECN1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21358617 22441670 23030059 23377657 23974797
ATG14 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 19270693 19050071 25594178 19223761 18843052 27513923 26496610 23954414 23332761 22081109 20562859 26108642 25891078 24034250 23112296 32296183 24980960 19270696 21062745 20711182 25490155
ULK1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 26390974 25545884 28301741 29734735 29233870 30292171 28518135 29313410 24191236 26546165 24848530 25026281 26921696 25026296 25373623 17595159 16940348 26108642 29371398 25891078 23685627 24370004 26008601 28238651 30397185 29233871 24834848 29867359
AMBRA1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20562859 23974797 20711182 20417604 21358617 25438055 23954414 20921139 24587252 17589504 25499913 33562550
BECN1 PIK3R4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20562859 18843052 20711182 18957027 25490155 26496610 19270696 19050071
BECN1 PIK3C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 18628207 36042481 19713971 19050071 16179260 25594178 21936852 18843052 24980959 28128446 25906440 26496610 26783301 23954414 19379691 23332761 20562859 23974797 24034250 16390869 24980960 19270696 25825496 19172397 20711182 23315026 25490155 24472739 17438366 23364696
SREBF1 SCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11414710 16943421 22279139 23221600 18481202 16368743 10400691 23019225
TSC2 TSC1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
TSC2 TSC1 â—¼   PROTEIN_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
AKT1 TSC2 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
TSC2 RHEB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12906785 16636147 17680028 19022819 20146692
TSC2 TSC1 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
PRKAB1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18692468 19339977 14651849
PRKAA1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19339977 33271062 14651849 16959574 15261145 28591720 18692468 20363874
AKT1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 75.0 1.0 Omnipath 16873412 12820960 17018601 11756412 32308763 11923280 16697215 19690332 21893193 20398329 18372248 21177249 12438239 18466115 15808505 29042482 20138985 15342917 17597835 20214616 12271141 16702951 20837138 17570479 26844273 15169778 17386266 10949026 16288292 24590173 11715018 15661536 18636226 18411301 20028854 9812896 16636147 20169078 17680028 12172553 19664994 18707149 10722653 12150915 18570873 20832730 12364343 17052453 18283331 21666717 27451907
TSC2 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 15340059 15854902 23331499 16636147 12869586 17680028 21071413 20146692 12771962 20226003 12906785 12842888
TSC2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 84.0 1.0 Omnipath 12167664 16424383 12511557 21134130 14551205 10915759 11741832 15340059 20166753 23331499 15342917 9580671 21071413 16464865 15851026 11290735 9809973 15851513 12869586 10807585 15963462 10585443 11741833 20412061 20226003 11175345 25263562 16339216 18411301 16636147 14651849 17658474 17693255 12176984 17077083
USF1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18955796 21389977 14757763 16457817 15983197 16488890
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
RAF1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
RAF1 LAMTOR3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
RAF1 LAMTOR2 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
PRKACA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19007248 11971957 20166139 18767875 20230923 9001246 10576742 23331499 20068231 7935389 18669648 18691976 9922370 15664191 19651622 12801936 9091312 10862777 9710607 11997508
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
KSR2 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12975377 23331499
PRKAA1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 12801936 19007248 11971957 20166139 20068231 9091312 10576742 9710607 11997508
RHEB RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15854902 16803888 15150271 16189514 9001246 19222999
RAF1 YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19608861 16093354 16041367 11697890 8702721 16189514 25852190 7644510 15459208 17979178
RAF1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15485920 10523633 9819434 10486249 16189514 19058874 21139044
CEBPB PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23564453 19491401 18467525 24353183
PRKAA1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20640476 17609368
AKT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17554339
TSC1 RHEB â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12906785 14551205 16636147 17604271 17680028 17693255 19022819 20146692
AKT1 RHEB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
TSC1 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17604271 16636147 20006481 17680028 20146692 14551205 17693255
GAPDH RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19451232
PIK3C3 ATG14 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
ATG14 PIK3R4 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
PIK3C3 ATG14 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
ATG14 PIK3R4 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
ULK1 ATG14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 27938392 29371398 30397185 23685627 29313410
ATG14 PIK3C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18843052 19270693 22493499 19050071
PIK3C3 PIK3R4 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
PIK3C3 PIK3R4 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
PIK3R4 PIK3C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20562859 27411398 8999962 18957027 21575909
NFE2L2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24466341 17640564 18588981 15655294 22951256
GLI1 ULK1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 PRKACA â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
PRKACA GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16481469 23331499 20027184 16293631 19996099
PRKAA1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 26843621 26190112
AKT1 TSC1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
AKT1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12167664 11756412 11923280 16697215 20398329 18372248 15808505 20138985 20214616 15169778 10949026 16288292 11715018 18636226 9812896 17680028 12172553 10722653 12150915 18570873 20832730 17052453
SP1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12759366 19105596 15722551 18624763 12684688 9614091 10574932 10713142 15061658 12270858 15180995
SP1 SLC25A5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10393330 10446910 8702555 10449239 11683873 10657244
SP1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19716432 20971080 20179320 24458133 18068676 17449871 15462672 21696544 15330762 22511764
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
SP1 INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 1311316 18310298 7776968 15131018 12706836 12665574 7983788 16707431 22033326
SP1 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19540905 15651981 23307400
SP1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12759366 16574895 16790435 9458366 9415398 12169688 10949931 12694408 11562358
SP1 HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7553870 9060426 2674689 24669866
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18801742 12760745 8007947 1588949 17384411 21465530 15618023 7896792
SP1 LEP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16011026 18559540 16931573 12760745 11162472 10428494 19408304 23254958 17496155
SP1 ACACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9240931 8576128 9271397 8663083
MAPK8 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28831131 22266860 18199680 19245816 25398907 17570479
SP1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 18068676 10224053
AKT1 SLC38A9 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGC â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGD â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
CAMKK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14500673 11445557 12149249 10833263 9859994 9868760 9368760 11278835 10226025
AKT1 GATA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 27053161 16107690 20101202 8206977 26680303
AKT1 SRPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19592491
AKT1 PFKFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28235572 15896703
AKT1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759249 20166139 11756412 10376603 11923280 12446767 16697215 11044445 20398329 18372248 11696579 16126727 16839566 15808505 20138985 20299462 10908731 20363286 11988487 11425855 20214616 23103584 11729179 16043647 17570479 12171920 25460366 27322328 11978735 15169778 11029403 25241761 19654415 10949026 18048761 11715018 12791703 24379783 18636226 9812896 23397142 17680028 10376602 12431978 10722653 20832730 18570873 25009123 17052453
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19376078 16340011 16083285 26506913 27784766 24467442
AKT1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26553800 24492612 27521372 26216216 25949795 21151116 21565170
AKT1 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19651622 17924679 18767875 23457334 10521487 20068231 1322130 12853467 17570479 19413330 18669648
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
RB1 CDK4 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CDK4 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 107.0 1.0 Omnipath 26203195 10498883 23336272 9315635 17303408 17363486 25803170 10359571 15081408 16236519 28249908 16936279 17478427 19690332 11520855 31615938 15279786 16326706 18981099 9190208 8626527 14627988 7575488 24417566 9003781 16360038 10385618 9736735 9139732 7736585 20068231 34158578 16189514 19075565 18669648 11773438 11641415 21880723 18590585 27708221 10962560 20068082 15489884 9425340 19225156 19551155 17045206 10210318 19262748 18786381 17660363 17621266 19651622 12657252 11746527 11254678 15809340 22263797 10202152 10778858 27811360 23981302 19664994 14676836 9380698 18583321 23429262 27430527
ULK1 AMBRA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23524951 25438055 20921139
CEBPB INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18310298 8288055 12665574
GAPDH AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 8872471
PRKACA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 28003367 23060444 25867080 21455600 30600261 1716180 28242698 19328185 32102849 92316961 19095655 14602047 7530719 10581361 11053017 9385646 25330774 15657296 1377674
PRKAA1 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19419994 20861072 20952391 24727471 26079370 19095655 10862786
NAMPT INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28490838 15604363
SIK2 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 25484640 16308421 15454081 18669648 20577053
PRKAA1 HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27010499 18184930 21892142
PRKACA HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22865920 20716686
PA2G4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 15583694 9565586 12165860
AR PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12933667 10075669 9886819 15691881
PRKACA SYN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 3118371 12237306 7849051 14557263 10571231
PRKACA LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17785468 14641008 19018281 9636039 9417067 11581251
PRKACA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15319357 12522122 34204249 10376603 31923467 16839566 33429979 34026871 16946136 10908731 10671564 16270749 11729179 12171920 26132171 11978735 17572401 24379783 10376602 16873402
PRKACA PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12764152 17023420 27784766
PRKACA CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11574071 11574070 10187789
PRKACA ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7907095 2900138
PRKACA EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11500364 11171059 14709557 15024086
PRKACA SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16381800
PRKACA PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17924679 18767875 20068231 1322130 12853467 19413330 18669648
PRKAA1 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11069105 19651622 20640476 17924679 18767875 20068231 1322130 12853467 19413330 18669648
RRAGA RRAGC â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
MLXIPL ACACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17716660 21453770 20139635 20100709 15496471
AR RBPMS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535 17721441
AR PRPS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
NR0B2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 16713569 11735420
NR2C2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 10611280 16713569
MAPK8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24424504 21512132 21820033 16282370
MAPK8 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 28532298 14567915 17496919 19591900 21372320 19788416 15708980 8608010 16984892 20512932 20220133 21438496 20054826 19616017 23762064 15611655
PRKAA1 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20562859 17145710 18480843 8626596 17728241 21232561 16306228 8663446 25852190 8621713 23455922
CAMKK2 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 14985505 21918180 8910387 16054096 16054095 15509864 19197243 14614828 23625915 17244528 18692468 15980064 14511394 23583109
CAMKK1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14985505 21918180 8910387 14614828 23583109 15980064 14511394
PRKAA1 TBC1D1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17995453 20837646
PRKAA1 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21892142 20577053
PRKAA1 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 11171059 22669845 11500364 14709557 15024086
PRKAA1 KLC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21725060 21436401
PRKAA1 POU2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9368058 1684878
PRKAA1 GFPT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19170765 17941647
PRKAA1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24820971 23372762 28295473 21460634 19584320 21205641 21258367 28389629 34421918 34224814 25980607 32978258
PRKAA1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21338323 2165906 16188906 15033481 9636039 18398140
PRKAA1 ZNF692 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17097062
PRKAA1 TET2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 30022161 31901078
PRKAA1 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 28835357 19815529
PRKAA1 PFKFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17712357 9836440 12065600 16115917
PRKAA1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21459323 21892142 23825667
PRKAA1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19651622 11052978 20166139 9029219 18669648 18767875 2900138 12015362 20068231 18707149 7907095 7915280 16326698 18212344
PRKAA1 GBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 33208442 18063581 28389568
PRKAA1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12740371
PRKAA1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10376603 12446767 11729179 16043647 11696579 16126727 12791703 24379783 19131647 18303014
NR0B2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11535594 12716764 24318876 14672953 11679424 21725089 12601360 10594021 16527247
HNF4A G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15591035 11864989 22384829 16308421 12651943 15933209 14722127 19720831 15388792 15702243 12915406 18805788 20577053
HNF4A PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11981036 15912134 19933841 17022998
NR2C2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 12522137
NR0B2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11535594 23331499 15604093 21071413 20516075 16488887 16455805 14672953 10594021
HNF4A G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12651943 11544200 15933209
NR5A2 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20375098 11705994 10409629 24498423 14627819 17204240 11518759 20460755
NR0B2 NR5A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 14963109 21262773 11030331 15723037 20516075 21566081 22504882 12198243 11668176 20375098
PPARA NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17492134 12093797 17891158 15539630 15950726
ATG101 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20562859 23392225 19597335
NR0B2 NR1I3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 14963109 8650544 9773978 15000748
POU2F1 NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19467240 22349263 14630716 11134960 24459328
HMGA1 NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10085153 18279675 11056164 14630716 18937643
NR0B2 G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15358835 20688914 18505831 21081708 18459945 17909097 19720831
SREBF1 ACACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12871210 23300015 20139635 11994399 22279139 11907029
ULK1 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20562859 19225151 23392225 19597335 25686248 26118643 19211835
LEP LEPR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9463481 22405007 12226096 23331499 9207021 9218470 8608603 9786864
CAMKK2 PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064