Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PAX8 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9413150 11453662
CDKN2A MTA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1018389108 21555589
MTA1 HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23791785 16511565
HSP90AB1 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NR2C2 MAP3K14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16050801 12243350
CCNA1 CDKN1A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
PPARA ACOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20813756
TERT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18775701 6742757
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
AKT1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
CCND1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16461912 0506281103
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
HSP90AB1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21730179 1105160108
SMARCC1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 18581278
HNF4A AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474850 12466965
AR PIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 13679438 20610535
AR SMARCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 20610535
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19351840 20610535
AR NR2C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17655826 20610535
AR MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17636177 8798622
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
AR FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18391971
FOXO3 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18344987 18424439
BCL2 MAPK8 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733859 5217553
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
BCL2 XRCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18313378
HDAC3 BGLAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath
KLF8 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21518760 12820964
HDAC1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20049841 20821348
POU5F1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25128069 23433354
CD2AP UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DNMT1 CD70 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20223637 21550117
SOX2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath
HNF4A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17885207
TGFB1I1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14755691 16141357
TRIM28 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942393
ESR1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 10851069
PPARA CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16239970 18818403
HSP90AA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
TNF CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21887257 19287455
NANOG DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22795133
PRKAA1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28143904
TNF EED â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080539 0908486107
ESR1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10935492 12878732
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
ESR2 NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8816459 22622808
NR2C2 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11844790
TRIM28 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942393
NR2F2 HBG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11544252 19401563
HDAC3 TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18037959
TP53BP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16945145
NR2F2 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11981036 18474611
HNF4A TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20621834 16771709
HSP90AA1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SMARCC1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IRF8 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18802049 19718038
IRF8 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16484229
KDM1A KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17707232
KLF3 KLF8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18687676
LHX2 PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19146846 24262147
MAP2K6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11460167 10882101
WDR62 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19910486 30566428
NR2C2 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12169272 16157589
MMP1 MMP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 7780967 1371271
PAX6 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10885745 14673159
NR2C2 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17897957 17828308
POU5F1 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17211451
SOX2 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17211451
NFIC PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10085123 9593667
NR2C1 NR2C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12615366 17645519
NR2C2 XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16157589 10807933
TRAF6 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14633987
TRAF2 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12547194 14633987
TAB1 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14743216
NR2F2 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15506639 15331176
SH3RF1 RAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7987728 20696164
XRCC6 RBBP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TAB1 RBCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
XRCC6 SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
XIAP TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TRAF2 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
XIAP TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12048196
TP53BP1 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBB TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HDAC3 KDM1A â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
DDB1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24249678 26679995 25189618 34026424
TAB2 UBB â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
DOT1L UBB â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
SOX2 MTA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23667531 21532573
NR2C2 S10A4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 30463901
ANDR CHD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33640491 34585037
NR2C2 RPA49 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30463901 34079125
NR2C2 PR40A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 30463901
SNW1 PR40A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32814053 20467437
NR2C2 SMRC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 30463901
KI67 NR2C2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26949251 30463901
ESR1 DNJB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27483141 31527615
NR2C2 DNJB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30463901 33957083
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
CD70 ATM â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NR2C2 CBX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30463901 34079125
CD70 NR2C2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CUL4B UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 21145461
CUL4B RBBP4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23238014 34026424
ESR2 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25604459 29509190
TRAF6 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25499913 17353931
EED DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23238014 17041588
ESR1 SNW1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 19934264
SOX2 KDM1A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30442713 28794006
NR2C2 KLHL7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 30463901
SNW1 NR2C2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30463901 20467437
NR2C2 UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NR2C2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30585729 30463901
NR2C2 RBMX2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 30463901
RAC1 UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
SOX2 RBBP4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23667531 21532573
SOX2 VPRBP â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26186194 23667531
RBBP4 MTA1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
SOX2 SMRC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 35140242 28794006 21532573
CHD4 SMRC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28977666 22939629 11003653 16217013 32744500
SNW1 CHD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28977666 32744500 20467437
ESR1 KDM1A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 17289570 23403292 31527615
NCOR1 ESR2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29509190 12904255
KDM1A NR2C2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21670149 23455924 30463901
SMAD7 TAB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12589052 11737269
AKT1 CDKN1A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 31575057
PELI1 TRAF6 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
NANOG SOX2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
KDM1A SMRC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 22939629 28420882 26344197
AR CCND1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ESR1 HDAC4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16051668 19893013
SNW1 NCOR1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 14985122 20467437
TRAF2 TAB2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19150425 17384642 14633987 10882101
DNMT1 MTA1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
MTA1 CUL4B â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 34026424 26028330
HDAC3 AKT1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 29523594 20026773
CCND1 CDKN2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CUL4B HDAC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25189618 34026424
TAB2 TRAF2 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
HDAC1 SOX2 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
NR2C1 ANDR â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12949936 16713569
CBX3 XRCC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21888893 34079125
HDAC3 ESR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16469706 26487511 14722073 31527615 20348541
HDAC4 RBBP4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31040226 10220385
KLF3 KDM1A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 35140242 23455924
SNW1 XRCC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 30585729 20467437
CCND1 ESR1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDKN1A GADD45A â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ESR1 FOXO3 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PAX6 ANDR â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19790232 21935435
ANDR KDM1A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 34585037 27085459 33640491 28611094 20228790
ANDR SMRC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33640491 14966121 28611094 34585037
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ESR2 FOXO3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 18312651 29509190
SOX2 HDAC3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 23667531 21532573
NR2C2 HDAC3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21670149 12943985
SOX2 NCOR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 28794006 23667531 21532573
SMAD7 SMAD6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26555259 9256479
TRAF6 TRAF2 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8153045 21516116
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TRAF2 TRAF6 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CHD4 SMARCC1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IKBKB MAP3K14 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
IKBKB TRAF2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
TAB1 XIAP â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
KDM1A MTA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21670149 19703393 26028330
ANDR HDAC4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21242980 12943985
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
CHUK TRAF2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
VPRBP CUL4B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21145461 22038470 26496610 33355139 16949367 28416635 31973889
DNMT1 EED â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16357870 22094255
HDAC4 NR2C1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12943985 11463856
NR2C1 NR2C2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12093744 21670149 9737983 30463901
RAC1 XIAP â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26279033 22117219 25301945
MAP3K14 TRAF2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RBCK1 TNF â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
HSP90AA1 TERT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AR KLK3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CBX3 TRIM28 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MTA1 CHD4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21670149 24440720 28977666 26344197 12920132 24981860 32744500 26028330 9885572
HDAC1 ANDR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 34585037 11994312 26468294 15835920 16713569 15640443
ANDR HDAC3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16469706 33640491 12943985
KI67 CBX3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12485163 16713569 34079125
CBX3 PIM1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16713569 10664448
HDAC3 CCND1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16461912 20484017 12048199 15558026 15713663
NR2C2 HNF4A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 35140242 12522137
NCOR1 TAB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16469706 12150997
NCOR1 PPARA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
TAB1 TAB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
TNF TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
AKT1 GSK3A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PAX8 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632625
MTA1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 21670149 34026424 24981860 16511565 22939629 26496610 9885572 27098840 26344197 21258344 10840944 14722073 26028330 12920132 33264408 17922035 28514442 16189514 26949739 18451879 11146623 23752268 20585571 29997244
MTA1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18451880 16807247 12167865 11146623 12639951 31527615
TNFSF14 MAP3K14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8663299 9122217 12571250
AR CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17617741 20610535 22040886
PPARA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16220077 15120605 10988245
CXCL8 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18660381 17375198 11023497
NCOR1 ANDR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16469706 11971970 15598662 28549433 23518348 33640491 15256534 28611094 16914745 16713569 20974212 20812024 12089345 14593076 32814769
AKT1 ANDR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11156376 16210317 28708672 18332867 11404460
NR2C2 ANDR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33640491 10611280 16713569
ANDR CCND1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16461912 10344732 15558026 16713569 11328859
POU5F1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23041284 20683952
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
AKT1 NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23940660
NR2C2 APOE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15670754 12954636 19800043
TGFB1I1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10075738 11532379 21515881
AR KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16079795 22052438
FOXO3 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18344987
ESR2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19211725 18223478 20664923
HNF4A BGLAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19463978 24291646 8055923
SOX2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18456656 25482558
NANOG CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22378194 22381696
FOXO3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12391153 21294163
MMP9 CD44 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16631740 11872628 1707285
NR2F2 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10644740 11682620 12943729
NR2C2 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10644740 11682620 18174360
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
HSP90AB1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
CDKN1A RBBP4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PAX6 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20053773 11584062 17157287
LHX2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
NR2C2 CYP21A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11478808
POU5F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22795133 30140294
NCOR1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16469706 17400812 12145334 16713569 12738788 21182203 24051437
ESR2 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19022902 19746436 10706629 12630920 9473491 21182203 29509190 17991765
FOXO3 PRKAA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24257750 22848740 17711846
HDAC1 TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18381204 21669397
HNF4A S100A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17101323 19671543 21403839
JAZF1 NR2C2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 31281901 15302918 35016035
JAZF1 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15302918
MAPK8 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
SH3RF1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12514131
MAP2K7 MAPK8 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
SH3RF1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12514131
SH3RF1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9482736 12514131
NR2C2 TAB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15743758 18316610 12243350
NR2C2AP NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12486131
PRKAA1 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21478464
NR2F2 PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11981036
RXRB NR2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 10900149
PAX6 PAX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10804178 11003833 12721955
PPARA SLC27A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12118000 9933587 9642225
RXRB PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8384714 23331499 11237216
AR NCOR1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CHUK MAP3K14 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
DNMT1 HDAC1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
HDAC4 NCOR1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EED HDAC1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CHD4 MTA1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
HDAC3 HDAC4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
SQSTM1 TRAF6 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
TAB2 TRAF6 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
MAP2K4 MAPK8 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
CCNA1 CDKN1A â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
DNMT1 UBB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RBMX2 SNW1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
MAP3K14 CHUK â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 16498412 5218365
ESR1 NR2F2 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
CHD4 RBBP4 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
NANOG POU5F1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
HDAC1 DNMT1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22274925 10888886 15870198 21670149 17707923 10615135 26794444 17967891 20613874 12473678 17934516 23708667 27593931
RBBP4 HDAC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 21670149 24981860 22939629 26496610 34518534 11302704 11102443 27705803 17827154 10734134 10220385 9885572 10471499 26344197 21258344 12091390 9150133 16713569 11602581 12920132 20127688 9790534 17643391 11470869 19686092 12943729 9150135 28514442 16189514 27068747 10444591 19703393 11171972 15451426 23752268 20585571 9520398 11118440 31435636
HDAC1 KDM1A â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
EED RBBP4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
MAP2K7 MAPK8 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CCND1 CDKN1A â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
DDB1 VPRBP â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
POU5F1 SOX2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
HDAC1 MTA1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
HDAC1 RBBP4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MTA1 RBBP4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AKT1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 110.0 1.0 Omnipath 15772344 19797085 23549785 20371716 11884598 25584893 11583116 11520785 14550568 19920184 15710331 21530327 9065430 16188907 24632852 12515807 11289110 24879152 20110348 12890758 15333638 14633703 11803463 16123357 8524413 21868755 12054501 23142783 25714023 16585200 15808505 22497526 16767165 19117997 14744935 19443725 21118801 18691976 18209096 11563975 17192257 11085518 19369195 19043530 11896604 10716737 19914182 19996208 21441927 32645325 15805282 21464307 34381779 16223362 12181443 15755769 11331582 11035810 21445305 27331409 16987514 11340086 15723049 22499768 18701488 11749387 20686112 11509608 19413330 20233866 15950778 20708687 14660586 17386267 11577096 15371448 11956225 12649200 16476742 11254732 21575859 14988390 11779850 19574224 20739666 17200115
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
TNF MAP3K14 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7639698 25152365 19815541 8702708 7544915
TRAF6 MAP3K14 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF2 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9275204 11278268 23543740 18997792 20385093 25416956 15084608 10755617 16713569 9334169 25246529 20348096 20651737 20184394 9020361
TRAF6 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9275204 11278268 25241761 16286467 10921914 16189514 10075662
MAP3K14 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 17145710 11278268 10195894 9520446 14743216 9689078 9346485 16285893 10733566 10779355 10072079 11460167 10022904 10713178
MAP3K14 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 17145710 11278268 16498412 30833792 23915189 9346485 11520989 10072079 17563756 18515365 10887201 16223731 12556537 16286467 14743216 9244310 20348096 10094049 15140882 15208311 20685151 25241761 9742107 10229185 9520446 15084608 15994789 10713178 9819420 17150968 11239468 16691505 26948423 20651737 9020361
PELI1 PELI2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17675297 12496252 12860405 15917247 17997719
ESR1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15208657 16029657 19440537 14991571 18669446 17932106
CDKN1A CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12383116 25241761 8756624 29997244 16982699 7478582 10022926 32814053 15232106 16009130 16189514
PPARA ACOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8567672 7635967 9556573 20110263 16828988
RAC1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
AKT1 MMP9 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 17409395 17680028 18471976 19440036 19930715 19945467 20214616 20398329 20609352 21084277 22131018 23572150 23589069 24030100 25136802 26597054 27328425 27510662 27572739 29556339
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
RAC1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19568798 15169778 19720745 18925875 10949026 11715018 19143635 12393431 18636226 10617634 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
INS AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 29432553 23912456 11679435 23866690 17335965 24646332 23798298
AKT1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19376078 16340011 16083285 26506913 27784766 24467442
AKT1 XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23640046 25241761 17698078 14645242
AKT1 SH3RF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17680028 20214616 9859994 20398329 17535800
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
AKT1 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 25999477 22366458 10224060 17570479 22902867 15843522 18775701
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
AKT1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26553800 24492612 27521372 26216216 25949795 21151116 21565170
AKT1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15911620 15998799 17570479 30680530 11707464
AKT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11756412 11923280 16697215 20452955 27603133 20398329 18372248 15001356 15808505 10217147 19440234 20138985 12431783 10753973 17855660 19216069 28358423 20214616 11463845 9829964 17570479 17646672 16680151 11231573 15169778 12851486 31575057 25241761 23109003 21933447 10949026 16775416 23886938 26436589 16288292 11715018 16055744 18636226 15023346 9812896 12042314 17680028 24848107 16982699 11779850 10722653 20832730 18570873 20307683 34069970 17052453 15798220
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 GATA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 27053161 16107690 20101202 8206977 26680303
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17570479 16568092
AKT1 POU5F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23041284 24497960
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
FOXO3 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16061480 17522055 18687691
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
AR IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12237244 8824277 19074897 11049111 17374439 11410519 20610535 19363165
AR KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17433535 8626436 11059779 15640443 7686046 11006269 12111703 15368351 24307657 9316650 9719026 11867260 12376473 14767470 16275987 11994312 17075604 20181722 9211894 16342680 12917209 18092350 12648523 17011549 11238180 20069563 10547578 16140973 22245379 12539223 20568894 20103546 18758709 21981678 21541973 12463425 12958311 11894840 19389135 17534890 23662037 15923603 16434977 14517289 22695118 10075669 11377978 16137620 11299734 15131260 21780100 16508948 16425097 22473899 14715080 10625666 18640093 21885566 12670590 14729601 16452400 16081584 10898343 11571582 9044850 15833875 16914734 23884959 15640095 15543614 7514587 12376534 12114445 15557561 18780293 23667504 18829551 12782640 16724108 17426252 11504717 19274665 11034093 17566103 12651911 22179832 21308712 16373397 19013180 22155408 9052414 11532861 17094454 17653089 20709811 22654108 22597536 15514031
AR BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17655826 11567031 23160675 20610535
NR2C1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 16713569 12949936
HDAC1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11994312 16713569 15640443 12612053 10428808
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
KDM1A AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17277772 16079795
TGFB1I1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11155740 11779876 11856738 8643607 16713569 10075738
NR2C2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 10611280 16713569
MAPK8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24424504 21512132 21820033 16282370
AR KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1712248 19345326 25241761
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
AR NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15598662 11971970 16469706 14593076 15256534 23518348 16713569 12089345 16914745 20812024 20974212
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
ATM TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 25128619 22496453 34194047 30323812 26158765 16862143 28607002 19584288 20858735 28851455 18285803 34419074 17833484 22491012 25404613 21642969 28439615 27364555 27602502 26671524 23096706 23935532 28739276 24754998 25905708 28847822 24461736 23318425 23346550 17178852 27432546 27820601 17942393 21868291 32060145 22205726 25846574 26293668 25533843 23034801 23352131 28249048 23633913 17525332 18657500 24794298 23645696 26212333 23050241 22715096 27376578 23370278 24657165 29540829 25173936 19071136 28847828 20424263 34518220 25956864 23554604
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20932475 21872579
BCL2 TRAF2 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
MAPK8 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 12421819 26609913 17097560 16738310 21726807 10567572 21993018 29950132 20919655 22848813 15225643 19029119 9738012 18570871 9115213 12039864 11323415 15733859 18471544 15703383 23329792 10677502
ESR1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 11477579 12554765 12808053 17166846 22892083 21505052 18414489 9832502 23864650 22396492 22266855 11358796 23891847 22948256 11986316 15282324 15496458 22521644 14764652 15178330 23108396 11410592 15026472 17998543 17681750 18245487 20821348 16860316 11844790 19858209 12929585 15808510 18997820 15217513 16809759 10500157 16980581 17914104
ESR2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15313930 14764652 18607069 23891847 11986316 18223478 14729654
CDKN1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 26203195 23443559 17145710 25416956 7478582 9837900 21988832 21516116 7777546 15232106 16082198 27107012 15695403 8657154 8242751 23007395 9106657 12383116 17556661 8756624 8662825 31515488
KLF8 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CHUK CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 10910956 17666529 9832503 23343194 21285352 18974774 10766840 22761862 22290435 16039586 16103118 19619488 19623618 15212693 17143292
ESR1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8649771 11073968 16061635 9039267
CD36 TRAF6 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 18070982 15247281 21220427 12140561 12138165 8837778 19592497 18347055
PPARA CD36 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12118000 12419306 9642225 16713233 11867619 20110263 16556603 16890192
DNMT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21229291 21572997 19056828 16276353 9588214 21868513 23658227
NCOR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22253232 20466759 20696891 24821728 24821727
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
SMAD7 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10878024 15922743 20104486 12185267 15555279 11180003
FOXO3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18312651 18005957 16908841 20671123 21249150
PIM1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 12431783 17855660 10753973 25121590 31575057 25749412 11756412 20647331 11779850 20307683 15001356
HDAC3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9618481 17550342 12545156 15155580 22796940 22370643 16533812 17508028
FOXO3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
HDAC4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18632985 18850004
MAPK8 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12730199 15964852 17325029 19664994 12058028 11779850 17570479 20519948 16964243 18669648
IKBKB CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21619050 20152798 29292732
TRAF2 CHUK â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
TAB1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
TRAF2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15725726 12547194 11359906 25241761 20449947 9244310 16713569 23007157 10795740 24323043 19150425
TRAF6 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15836773
TAB2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14960582 15836773 11274345 20194509 18855897
CHUK FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15084260 23691078 20300203
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
DNMT1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21765477 24875904 23335796 22742857
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
MAPK8 ELK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 11042694
KDM1A ESR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
FOXO3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24062311 16807346 16809346 17575143
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23733894 15334655 16483936 12237295 20664923
ESR1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21411498 12122114 21693539 18519947 16690106 10805720 19360348 23409030 18754863
ESR1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20616010 20068169 16950141 21029304 19433249
NR2C2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11844790 10611280
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
FOXO3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11435445 15367686 16807346 18312651
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ESR2 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12122114 10805720
FOXO3 MMP9 â—¼   UP_REGULATES ✅ + 8.0 1.0 ACSN 10048576 16079281 16288288 16556862 17646672 19564415 22439866 8844971
FOXO3 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16840535 22563476 19608644 12027802
FOXO3 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11964479 15721278 12048180 18845647 21835778
PRKAA1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17900900 17711846 22848740 29445193
PIM1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15837797 21777391 33408118 26376801 10102273 18593906
IKBKB FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 25241761 20300203 20625400 25849741 23691078 23262029 19701188 21911455 22649777 21443462 15084260 22531926 16806782 30142927 19188143
FOXO3 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14976264 18644865 10783894 16288288 20673124 11094066 17646672 15509806 11994454 11154281
GADD45A MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10367887 21614932 12738796 11274345 18855897
GATA1 HBG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 1379347 1688723 16200778 20395365 2336386 19114560 24245781 21609963 19447160 18443038 2474800 21220744 2734104 8445949 12567445 8262042 12609092
HDAC1 HDAC3 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 NCOR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 HDAC3 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 NCOR1 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 TNF â—¼   DOWN_REGULATES ✅ - 15.0 1.0 ACSN 10754326 10952726 11875494 12907458 14660645 14668329 15465827 15644117 16878026 17404308 17485448 21234400 22796940 23390297 7594497
HDAC1 HDAC3 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC3 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11302704 16189514 23213415 10944117
HDAC3 NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11509652 11013263 16195251 11931768 16469706 21258344 17694085 10860984 16917504 10944117 23752268 16713569 14527417 11466315 11804585 12628926 15601853
HNF4A PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11557972 7831301 16308421 12840167 7935427 14722127 7819133 19720831 20577053 19651778
HNF4A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18555664 10491332 10720084 11994285 14612449 19252740
HNF4A PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11981036 15912134 19933841 17022998
NR2C2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 12522137
PRKAA1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12740371
PPARA HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12482853 12962497
TRAF2 IKBKB â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
NR2C2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 29748387 12547194 28159912 25659581
TRAF2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 27387502 15725726 12547194 11359906 25241761 20449947 16713569 18362886 23007157 10795740 21119000 19150425
TRAF6 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16260493 15691841 15620648 15327770 10195894 16186825 16493424 17965022 10094049 10837071
IL6 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
PAX6 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 22426149 15047618 22974359 15180990 20943817 22403172 22764048 12426319 18199433 11845228 9224716 10891400 21983268 9230347
IRF8 MMP9 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10734131 11672593 11875494 11964313 12032143 12417340 12811837 16243976 16413922 16597464 17404308 17485448 22461508 23390297 24091328
KLF8 MMP9 â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
NR2C2 LHCGR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10644740 11682620 18174360
RAC1 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
TAB2 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TRAF2 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
TRAF2 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
RAC1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17496910 18000759 15574420 19151919 10727406 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353 11562357
TAB1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20060931 21614932 12738796 11274345 18855897
TAB2 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20060931 21614932 12738796 11274345 18855897
MAP2K4 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 17143273 10713157 11489946 7600581 8702918 17145710 13130464 23416355 10748139 8805275 18855897 10791986 9108083 19690332 95141073 18083107 9724739 12788955 9305638 23331499 19534553 15068801 7839144 10958661 21071413 23047924 11062067 21614932 9808624 12738796 15911620 15998799 9891069 11389443 18988627 9733714 11847100 18669648 16153436 10521444 15302099 16282370 11242034 14523011 12709432 26370088 9661668 10499589 7652575 16076903 7992057 16440308 7600582 17192257 9860979 15755722 12133933 16533805 19369195 9312068 9207092 10385525 12354380 12917261 8910292 9487126 9448004 10962008 12624093 11274345 11099046
TRAF2 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
TRAF6 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
TRAF2 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
TRAF6 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21614932 12738796 11274345 16313339 18855897
TAB1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20060931 21614932 12738796 11274345 18855897
TAB2 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20060931 21614932 12738796 11274345 18855897
RAC1 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
TRAF2 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
RAC1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353
TRAF2 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
MAP2K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 12821118 10713157 11489946 17145710 9362518 13130464 18855897 19690332 95141073 24975362 23331499 7839144 21071413 18362184 11062067 21614932 15911620 12738796 18436711 11389443 10506143 11242024 11847100 18669648 16153436 15725726 25241761 18691976 14523011 25284480 16076903 17192257 11390361 15755722 16533805 19369195 9312068 9207092 9733513 12758252 12624093 15212693 11274345
RAC1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17251915 12213839 18423204 18426980 10592173 22252525 10930450
TRAF6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
MAPK8 PAX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11700324
MAPK8 WDR62 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 26186194 19910486 30566428 34137789
PPARA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17077283 21840940 19576184
POU5F1 NANOG â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20925113 17506876 16153702 20526341 19829295 22855527 17068183
SOX2 NANOG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17068183 16153702 21816365 19829295
SOX2 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22745796 23939864 15860457 18537119 17324942 19522013
POU5F1 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18662995 22745796 15860457 20505756 18537119 19522013 18687992 17272500 18338330 17068183
NCOR1 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15870285 19955185 18292238 11903058 16713569 10336495 21775429
NR2C1 TNFSF14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17389641 10855696 18155158 12615366
TAB2 NR2C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14633987 17158449
NR2F2 POU5F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23136034 8152920 7823919 8289793
PAX6 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19666824 17825048 11358870
SMAD6 PELI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16951688 19352540
POU5F1 SOX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20505756 12136102 17324942 15988017 17068183
PPARA TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11009565 17463321 17260462 15669179 19039651 10377130 19640904 19576184 15891579 19225884
SMAD6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
SMAD7 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
SMAD7 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 17384642
TRAF6 SQSTM1 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
TRAF6 SQSTM1 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
SQSTM1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15870274 27458013 10747026 27681126 16079148 16189514 18382763 16874300 11244088 17389358
TAB2 TAB1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 TAB1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TRAF2 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 14743216
XIAP TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9878061 12048196 17560374 27107012 11865055 23818254
TRAF6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21305609 17145710 11809792 12242293 19775907 10882101 25290089 10094049 30782845
TNF TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF6 TAB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF2 TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF6 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 17145710 15492226 19675569 15932500 18180283 16251197 10882101 18299187 11259596 1551980 24061540 21988832 19112497 22924441 11518704 11809792 15836773 14633987 14751757 25290089 12496252 12609980 12242293 24735611 14982987 15327770 17720800
TRAF2 TNF â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 TNF â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 TNF â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
XRCC6 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368