Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships

About ProteinKG

A protein relationship knowledge graph

Public Data Processing

Collation

DatabaseShort DescriptionNumber of EntriesScoring System
BioPlexA protein-protein interaction database containing ~120000 interactions among ~15000 proteins. Profiling protein-protein interactions in human cells by affinity-purification mass spectrometry in human 293T and HCT116 cells.104,485Identifying high-confidence interreacting proteins (HCIP's) using the Normalized Weighted D-Score and Z-Score. Interactions scores of at least 0.75 are considered HCIP's.
OmnipathA database of molecular biology prior knowledge combining data from >100 resources containing protein-protein and gene regulatory interactions, enzyme-PTM relationships, protein complexes, protein annotations and intercellular communication.202Developed based on the number of publications reporting an interaction.
STRINGA database of known and predicted protein-protein interactions. Interactions include direct (physical) and indirect (functional) associations. They stem from computational prediction, from knowledge transfer between organisms and from interactions aggregated from other (primary) databases.37081Indictor of confidence, i.e. how likely STRING judges an interaction to be true, given all available evidence. All scores rank from 0 to 1 with 1 being the highest possible confidence.
CORUMA comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases.1,636Developed based on the number of publications reporting an interaction.
HuRIA protein-protein interaction database containing ~17500 interactions detected by high throughput yeast two-hybrid screens. This database also includes interactions of high quality extracted from literature.10,237Indicator of confidence to rank human binary protein interactions identified in systematic screens based on their biophysical quality.
ReactomeAn open-source manually curated and peer-reviewed pathway database. Providing a bioinformatic tool for visualising, interpreting and analysing pathway knowledge to support genome analysis and systems biology. Entities including proteins, complexes, and small molecules form a network of biological interactions.20,630Developed based on the number of publications reporting an interaction.
XLinkDBA protein-protein interaction database integrating tools for network analysis. Incorporating cross-linking data and model scoring scripts to identify interactions and analyse structural landscape predicted by crosslinking with mass spectrometry.3393Indictor of confidence, estimating the reliability of the interaction, given the available experimental evidence based on a heuristic integration.
BioGRIDA biomedical interaction repository with data compiled through comprehensive curation efforts with 2,604,369 protein and genetic interactions, 30,725 chemical interactions and 1,128,339 post translational modifications from major model organism species.91917Developed based on the number of publications reporting an interaction.
SignorA resource annotating experimental evidence about casual interactions between proteins and other entities of biological relevance. The curated data is displayed as signed directed graphs by a graph drawing tool.12,500A score to support the functional relevance of the considered relationship. Based on the number of annotated articles reporting work that support the interaction and relationship occurrence in the Human Protein Interactions file from Reactome.
MINTA protein-protein interaction database integrating experimentally verified interactions mined from scientific literature by expert curators.1,129A score estimating the reliability of the interaction, given the available experimental evidence based on a heuristic integration. The value of 0.50 is evidence supporting association, which may be indirect between the two partners.
InnateDBA publicly available database of genes, proteins, experimentally verified interactions and signalling pathways involved in the innate immune response of organisms. Integrating known interactions and pathways from public databases together with manually curated data into a centralised resource.1,896Developed based on the number of publications reporting an interaction.
HIPPIEA protein-protein interaction database, providing confidence scored and functionally annotated human interactions.180Indicator of confidence based on the amount and reliability of evidence supporting the interaction. Calculated as a weighted sum of the number of studies in which an interaction was detected and the number and quality of experimental techniques used to measure the interaction.
ACSNA multi-scale resource of biological maps depicting molecular processes in cancer cells. Depicts molecular mechanisms at the level of biochemical interaction, forming a seamless network of >8,000 reactions covering close to 3,000 proteins and 800 genes.13,019Developed based on the number of publications reporting an interaction.
IntActAn open-source database and analysis tool for molecular interaction data derived from literature curation or direct user submission currently comprising of 118924 interactors and 750480 interactions.93A heuristic scoring system considering how the interaction was inferred, the interaction type and the number of publications reporting a scientific interaction.

Cleaning & Formatting

  • Process datasets into a tidy format
  • Homogenise column names and order
  • Resolving protein synonyms

Homogenising relationship nomenclature

  • Collapse similar relationship names
Original LabelCollapsed LabelRelationship ClassDatabase
CATALYSISCATALYSISBIOCHEMICAL_REACTIONACSN
UNKNOWN_CATALYSISCATALYSISBIOCHEMICAL_REACTIONACSN
oxidoreductase activity electron transfer reactionCATALYSISBIOCHEMICAL_REACTIONReactome
nucleoside triphosphatase reactionCATALYSISBIOCHEMICAL_REACTIONReactome
phospholipase reactionCATALYSISBIOCHEMICAL_REACTIONReactome
catalytic activityCATALYSISBIOCHEMICAL_REACTIONSIGNOR
cleavage reactionCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONReactome
cleavageCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONSIGNOR

See full table

Calculating edge features

  • Calculate and normalise relationship scores
  • Ascertain relationship directionality and sign
  • Extract source and reference URLs

Filtering relationships

  • Remove duplicate interactions
  • Filter out relationships with low scores

Appendix

Full Relationship table

Original LabelCollapsed LabelRelationship ClassDatabase
CATALYSISCATALYSISBIOCHEMICAL_REACTIONACSN
UNKNOWN_CATALYSISCATALYSISBIOCHEMICAL_REACTIONACSN
oxidoreductase activity electron transfer reactionCATALYSISBIOCHEMICAL_REACTIONReactome
nucleoside triphosphatase reactionCATALYSISBIOCHEMICAL_REACTIONReactome
phospholipase reactionCATALYSISBIOCHEMICAL_REACTIONReactome
catalytic activityCATALYSISBIOCHEMICAL_REACTIONSIGNOR
cleavage reactionCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONReactome
cleavageCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONSIGNOR
cleavage reactionCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONMINT
cleavage reactionCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONPINA
protein cleavageCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONPINA
CLEAVAGE_REACTIONCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONReactome
DNA_CLEAVAGECLEAVAGE_REACTIONBIOCHEMICAL_REACTIONIntact
rna cleavageCLEAVAGE_REACTIONBIOCHEMICAL_REACTIONPINA
covalent bindingCOVALENT_BINDINGBIOCHEMICAL_REACTIONPINA
covalent bindingCOVALENT_BINDINGBIOCHEMICAL_REACTIONMINT
dephosphorylation reactionDEPHOSPHORYLATIONBIOCHEMICAL_REACTIONPINA
dephosphorylation reactionDEPHOSPHORYLATIONBIOCHEMICAL_REACTIONMINT
disulfide bondDISULFIDE_BONDBIOCHEMICAL_REACTIONMINT
disulfide bondDISULFIDE_BONDBIOCHEMICAL_REACTIONPINA
enzymatic reactionENZYMATIC_REACTIONBIOCHEMICAL_REACTIONReactome
ENZYMATIC_REACTIONENZYMATIC_REACTIONBIOCHEMICAL_REACTIONReactome
enzymatic reactionENZYMATIC_REACTIONBIOCHEMICAL_REACTIONPINA
enzymatic reactionENZYMATIC_REACTIONBIOCHEMICAL_REACTIONMINT
oxidoreductase activity electron transfer reactionENZYMATIC_REACTIONBIOCHEMICAL_REACTIONMINT
KNOWN_TRANSITION_OMITTEDFOLDING_REACTIONBIOCHEMICAL_REACTIONACSN
guanine nucleotide exchange factorGTPASE_REACTIONBIOCHEMICAL_REACTIONSIGNOR
gtpase-activating proteinGTPASE_REACTIONBIOCHEMICAL_REACTIONSIGNOR
gtpase reactionGTPASE_REACTIONBIOCHEMICAL_REACTIONReactome
guanine nucleotide exchange factor reactionGTPASE_REACTIONBIOCHEMICAL_REACTIONMINT
gtpase reactionGTPASE_REACTIONBIOCHEMICAL_REACTIONPINA
HETERODIMER_ASSOCIATIONHETERODIMER_ASSOCIATIONBIOCHEMICAL_REACTIONACSN
INHIBITIONINHIBITIONBIOCHEMICAL_REACTIONACSN
isomerase reactionISOMERASE REACTIONBIOCHEMICAL_REACTIONReactome
oxidationOXIDATIONBIOCHEMICAL_REACTIONSIGNOR
palmitoylationPALMITOYLATIONBIOCHEMICAL_REACTIONSIGNOR
phosphorylation reactionPHOSPHORYLATIONBIOCHEMICAL_REACTIONMINT
PHOSPHORYLATION_REACTIONPHOSPHORYLATIONBIOCHEMICAL_REACTIONIntact
proline isomerization reactionPROLINE_ISOMERIZATIONBIOCHEMICAL_REACTIONMINT
relocalizationRELOCALISATIONBIOCHEMICAL_REACTIONSIGNOR
COMPLEX_EXPANSIONSHARES_COMPLEXBIOCHEMICAL_REACTIONACSN
SHARE_COMPLEXSHARES_COMPLEXBIOCHEMICAL_REACTIONCorum
UNKNOWN_TRANSITIONSTRUCTURAL_CHANGEBIOCHEMICAL_REACTIONACSN
STATE_TRANSITIONSTRUCTURAL_CHANGEBIOCHEMICAL_REACTIONACSN
destabilizationSTRUCTURAL_CHANGEBIOCHEMICAL_REACTIONSIGNOR
sulfurtransfer reactionSULFUR_TRANSFERBIOCHEMICAL_REACTIONReactome
transglutamination reactionTRANSGLUTAMINATIONBIOCHEMICAL_REACTIONPINA
translation regulationTRANSLATIONAL_REGULATIONBIOCHEMICAL_REACTIONSIGNOR
TRANSLATIONTRANSLATIONAL_REGULATIONBIOCHEMICAL_REACTIONACSN
genetic interactionNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONPINA
Negative GeneticNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Dosage LethalityNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
NEGATIVE_GENETICNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
SYNTHETIC_LETHALITYNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
DOSAGE_RESCUENEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
suppressive genetic interaction defined by inequalityNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONPINA
Phenotypic SuppressionNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Synthetic Growth DefectNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Dosage Growth DefectNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
synthetic genetic interaction defined by inequalityNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONPINA
SYNTHETIC_GROWTH_DEFECTNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
PHENOTYPIC_SUPPRESSIONNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
Synthetic LethalityNEGATIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
additive genetic interaction defined by inequalityPOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONPINA
Positive GeneticPOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Phenotypic EnhancementPOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Synthetic RescuePOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
Dosage RescuePOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGRID
PHENOTYPIC_ENHANCEMENTPOSITIVE_GENETIC_INTERACTIONGENETIC_INTERACTIONBioGrid
colocalizationCOLOCALIZATIONLOCALIZATIONPINA
proximityCOLOCALIZATIONLOCALIZATIONMINT
colocalizationCOLOCALIZATIONLOCALIZATIONMINT
PROXIMITYCOLOCALIZATIONLOCALIZATIONIntact
COLOCALIZATIONCOLOCALIZATIONLOCALIZATIONIntact
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONIID
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONSTRING
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioPlex
physical associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONHuRI
physical associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONReactome
physical associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPINA
POST_TRANSLATIONAL_REGULATIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONOmnipath
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPIPs
Affinity Capture-WesternPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Affinity Capture-MSPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Reconstituted ComplexPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
direct interactionPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPINA
associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONMINT
physical associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONMINT
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONXLinkDB
Two-hybridPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Biochemical ActivityPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
associationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPINA
direct interactionPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONMINT
Proximity Label-MSPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
bindingPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONSIGNOR
Co-localizationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONInnateDB
Co-crystal StructurePHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Protein-peptidePHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Co-purificationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Co-fractionationPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Affinity Capture-LuminescencePHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
FRETPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
PHYSICAL_ASSOCIATIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONReactome
Far WesternPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
Affinity Capture-RNAPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
PCAPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
ASSOCIATIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONIntact
Protein-RNAPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGRID
PHYSICAL_ASSOCIATIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONIntact
PROTEIN_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONHIPPIE
PHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONBioGrid
PHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONSTRING
DIRECT_INTERACTIONPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONIntact
physical interactionPHYSICAL_INTERACTIONPHYSICAL_INTERACTIONPINA
acetylation reactionACETYLATION_REACTIONPOST_TRANSLATIONAL_MODIFICATIONReactome
acetylationACETYLATION_REACTIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
acetylation reactionACETYLATION_REACTIONPOST_TRANSLATIONAL_MODIFICATIONMINT
acetylation reactionACETYLATION_REACTIONPOST_TRANSLATIONAL_MODIFICATIONPINA
adp ribosylation reactionADP_RIBOSYLATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
adp ribosylation reactionADP_RIBOSYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
ADP-ribosylationADP_RIBOSYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
amidation reactionAMIDATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
demethylationCARBOXYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
carboxylation reactionCARBOXYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
de-ADP-ribosylation reactionDE-ADP-RIBOSYLATION POST_TRANSLATIONAL_MODIFICATIONReactome
deacetylation reactionDEACETYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
deacetylation reactionDEACETYLATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
deacetylation reactionDEACETYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
deacetylationDEACETYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
deglycosylationDEGLYCOSYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
demethylation reactionDEMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
carboxylationDEMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
demethylation reactionDEMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
deneddylation reactionDENEDDYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
deneddylation reactionDENEDDYLATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
deneddylation reactionDENEDDYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
dephosphorylationDEPHOSPHORYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
dephosphorylation reactionDEPHOSPHORYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
desumoylationDESUMOYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
deubiquitinationDEUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
deubiquitination reactionDEUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
deubiquitination reactionDEUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
deubiquitination reactionDEUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
glycosylation reactionGLYCOSLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
glycosylationGLYCOSLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
hydroxylation reactionHYDROXYLATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
hydroxylationHYDROXYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
hydroxylation reactionHYDROXYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
isomerizationISOMERIZATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
lipidationLIPIDATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
methylationMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
methylation reactionMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
methylation reactionMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
monoubiquitinationMONOUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
neddylationNEDDYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
palmitoylation reactionPALMITOYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
phosphopantetheinylationPHOSPHOPANTETHEINYLATIONPOST_TRANSLATIONAL_MODIFICATIONReactome
phosphorylationPHOSPHORYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
phosphorylation reactionPHOSPHORYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
post transcriptional regulationPOST_TRANSLATIONAL_REGULATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
post translational modificationPOST_TRANSLATIONAL_REGULATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
s-nitrosylationS-NITROSYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
sumoylationSUMOYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
sumoylation reactionSUMOYLATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
sumoylation reactionSUMOYLATION POST_TRANSLATIONAL_MODIFICATIONMINT
trimethylationTRIMETHYLATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
tyrosinationTYROSINATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
ubiquitinationUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
polyubiquitinationUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONSIGNOR
ubiquitination reactionUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONPINA
ubiquitination reactionUBIQUITINATIONPOST_TRANSLATIONAL_MODIFICATIONMINT
DISSOCIATIONDISSOCIATIONREGULATIONACSN
UNKNOWN_INHIBITIONINHIBITIONREGULATIONACSN
NEGATIVE_INFLUENCENEGATIVE_REGULATIONREGULATIONACSN
NUCLEOSIDE_TRIPHOSPHATASE_REACTIONNEGATIVE_REGULATIONREGULATIONReactome
chemical inhibitionNEGATIVE_REGULATIONREGULATIONSIGNOR
UNKNOWN_NEGATIVE_INFLUENCENEGATIVE_REGULATIONREGULATIONACSN
transcriptional repressionNEGATIVE_TRANSCRIPTIONAL_REGULATIONREGULATIONSIGNOR
PHYSICAL_STIMULATIONPOSITIVE_REGULATIONREGULATIONACSN
TRIGGERPOSITIVE_REGULATIONREGULATIONACSN
POSITIVE_INFLUENCEPOSITIVE_REGULATIONREGULATIONACSN
chemical activationPOSITIVE_REGULATIONREGULATIONSIGNOR
UNKNOWN_POSITIVE_INFLUENCEPOSITIVE_REGULATIONREGULATIONACSN
neddylation reactionPOST_TRANSLATIONAL_REGULATIONREGULATIONMINT
MODULATIONREGULATIONREGULATIONACSN
TRANSCRIPTIONAL_REGULATIONTRANSCRIPTIONAL_REGULATIONREGULATIONOmnipath
transcriptional regulationTRANSCRIPTIONAL_REGULATIONREGULATIONSIGNOR
TRANSCRIPTIONTRANSCRIPTIONAL_REGULATIONREGULATIONACSN