Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 UBE3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23581475
AURKA AJUBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15630414
BLM ATRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
BRCA1 ATRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
ATRIP FANCI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20670894 23723247
ATRIP UBE2T â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20670894 23723247
ATRIP FANCD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20670894 23723247
CHEK1 ATRIP â—¼   COLOCALIZATION 2.0 0.8 intact 20639859 8010047
XRCC5 ATRIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18285803
BCL2 MAPK8 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733859 5217553
E2F4 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11559537 18319725
KPNA2 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9497340 6547667
JAK1 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213490 11163768
BRCA1 BRAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9497340 6547667
USF2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14502648
EZH2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23624935 21406404
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
BRCA1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11001824 19223505
FANCD2 BRCA1 â—¼   COLOCALIZATION 2.0 0.8 intact 11239454 5213674
BRD7 SERPINB9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FOXO3 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20211690 19807657
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17581882
AURKA CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001737 24358021
CDK1 BORA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16890155 18521620
TFDP1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14618416
PIN1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11774038 16713569
AURKA CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001737 24358021
RPA2 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10882098 10757793
CDK9 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
PPP1CC CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21533037
E2F4 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
RPA2 CHEK1 â—¼   COLOCALIZATION 2.0 0.8 intact 20639859 8010047
E2F4 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067 18319725
ERCC6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16319174
FOXO3 JAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12351634
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
AR FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18391971
FOXO3 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11884591
PPP1CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
MAPK3 PCBP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17475908
SUMO2 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SUMO1 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
PPP1R9B PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
RPA2 UBE2T â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20670894 23723247
SMARCA2 FAM184A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
AR SMARCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 20610535
SMARCC1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 18581278
TOP2A SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18394993 25114211
SUMO1 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20016603 25114211
PGR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14500579 16175636
SUMO1 UIMC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17698038
SUMO1 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18211901
TPR TOP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
E2F4 TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
TOP2A PIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11940573 5215253
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
BECN1 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0810452105 19050071
AR TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21303954 20610535
TP63 CASP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23703390 16103071
XRN2 TARDBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP1CB CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14592972 16467385
PIN1 CSNK2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11940573 5215253
PIN1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 9499405
PLIN3 PRKAA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 26902588 25961502
PRKAA2 PRKAG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16943194 8549768
CSNK2A1 CSNK2B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
E2F4 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574595 18319725
CSTF2 CDC73 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0812023106 19136632
TFDP2 E2F4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211277 10090723
E2F4 ZNF350 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812 20713352
E2F4 RBL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 DBF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15782160 18319725
E2F4 CSTF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 16135806
E2F4 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 14532106
AKT1 FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15461588 17570479
PPP1CA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8288823 20186153
ALYREF AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18562279 0802533105
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
PPP1CA AKT1 â—¼   COLOCALIZATION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288823 20186153
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
CDK4 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
BORA AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16890155
PPP1CC CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14592972 16467385
CCNB1 BORA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16890155 18521620
CTNNB1 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
CTNNB1 ECM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15642117 12782598
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23689136
EZH2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 23239736
AHR AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19815066 17392787
PRMT1 NRIP1 â—¼   METHYLATION ✅ 2.0 0.8 intact 5219239 17053781
LMNA NUP153 â—¼   COLOCALIZATION 2.0 0.8 intact 20561986 7893748
AHR CBR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22531821 17569794
RBL2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8253383 18319725
PGR KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9052414
BLM RPA2 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CSNK2A1 TOP2A â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
SUMO2 MDC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22661230 19394292 19471022 32786267
TFDP1 E2F4 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24981860
CDK4 RBL1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22094256 12006580
CDC73 RNF20 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
MDC1 UIMC1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
CBX1 SCAI â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
CDK2 E2F4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25852190
CDK2 CDK16 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
CDK9 PCBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27684187 17643375
CDK9 TPR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19293945 26209609
EZH2 HUWE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27634302 26496610
OS9 LOXL2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LMNA FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22412018 16248985
RBL2 RBL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15467457 17531812
UBE3A UBE3C â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22645313 29426014
HIST1H2AC HIST2H2AC â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
BRCA1 TERF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 19797051 29656893
BRCA1 TONSL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25184681 29656893
BRCA1 CDK16 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9738006 22990118 25184681 33961781 26186194
BRCA1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
CCNE1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9053846 9891079 1388288
OS9 EGLN3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26972000 15721254
SUMO2 PCBP2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34133714 19471022 25027693 21252943
ESR2 UBE3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33456993 17962381 25408199
RBL2 CCNE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9891079 8253383
CCNE1 RBL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8230483 9891079
CDK1 CDC25C â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 8119945
CDC25C CDK1 â—¼   DEPHOSPHORYLATION ✅ + 0.83 0.83 Signor 19574738
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRCA1 FANCD2 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 12485996
HIST1H2AB HIST1H2BB â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BRCA1 CDK2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
PIN1 BCL2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16713569 11988841 11326318
SUMO2 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21693764 16524884 16620772 19471022
MSH6 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10783165 15064730
USF2 BRCA1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14502648 16713569
BRCA1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25531315 23624935
CDK2 TFDP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 9199321 25852190
LMNA MDC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 30179224 22412018 30419336
XRCC5 TOP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28415827 21679440
TOP1 TOP2A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15848144 26344197
AKT1 AURKA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
CCNE1 CDK4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
LMNA TPR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22412018 29568061
TOP1 TP53BP1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MDC1 SMARCC1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
ABL1 JAK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9774693 12130510
SUMO2 BRCA1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20016603 20016594 22689573 21693764 21147198
BRCA1 TOP2A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15965487 25184681
UIMC1 CDK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19615732 23264621
CDK2 RBL2 â—¼   PHOSPHORYLATION 0.85 0.85 Signor 11157749
AKT1 ARNT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15833858 28628118 28205554
RBL2 CDK4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22094256 33961781
SUMO2 TPR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19293945 19471022 19394292 32786267 21693764
ACTN3 MYOZ1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
BRCA1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 34591612
AURKA BRCA1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22110403 14990569 26831064
JAK1 BRCA1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
BRCA1 FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22990118 20305393 16713569 26831064
LCK CDK1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 31980649
CDK9 CDC73 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26659056 17643375
PYCARD CASP1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 34589402
TOP1 TPR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22939629 30021884
PIN1 TOP2A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11940573 16713569
SUMO2 TOP2A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19471022 19394292 32786267 18381449 21252943 25027693 21693764 20797634
XRCC5 TOP2A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12393188 20085707
CDK4 ASPM â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 26496610
BAP1 IPO5 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19615732 29686263
CSTF2 CSTF1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10669729 26344197
RBL2 TFDP2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 33961781 17531812
HIST1H2AC SUPT16H â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
BLM MSH6 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
KPNA2 NUP153 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDK4 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17334399 16713569 9244350 12509456
ESR2 FOXO3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29509190 18312651
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BABAM1 UIMC1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BLM CHEK1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
POT1 TERF1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CTNNB1 SKP1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
TERF1 TNKS2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK2 SKP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK1 EZH2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
BRCA1 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25084169 10783165 26831064 29656893
BRCA1 CSTF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11257228 10477523
BRCA1 RBL2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 11521194
AKT1 FOXO3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21621563 10102273 25241761 21775285
SUMO2 UIMC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19471022 23211528 32786267 22689573 21693764 26719330
BECN1 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29669822 23112296 28628118 28205554
ILK AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 12149249 9736715 12176337 11445557 18339839 11825911 11313365 14500673 11278835 11546794
ESR2 NRIP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11500849 21182203 15604093
NRIP1 AHR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11551916 10428779
PPP1CA PPP1CB â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PPP1CB PPP1CC â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AR KLK3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
BRCA1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17352427 12024016
BRCA1 ATRIP â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17616665 24073851 29656893
BRCA1 BRAT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24073851 16452482
CSTF1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29180510 11257228 11278247
MDC1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21622030 19766185 15569676 12611903 17525332 12607005 29656893
NMI BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11916966 16713569
CCNB1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11278247 23246971 9244350
BAP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9528852 23850490 16713569
E2F4 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21102443 16713569 9244350
BRAP BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9497340 8955125 16713569
BRCA1 SUMO1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
ILK FANCI â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32707033 17353931 23455922
UIMC1 MDC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21622030 22990118 21857162 24240613 29656893
CTNNB1 AR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5216126 12588987
CDK2 RBL1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDK2 RBL2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ABL1 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19783996
BECN1 BCL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22498477 21971985 20889974 20010695 23504944 23564079 23168911 25891078 29955058 23822101 32097085 23954414 19959994 28128446 22241963 16179260 23316280 31410188 18641390 29079782 29849149 28682313 27304906 20711182 25984893 22622204 19180116 20622903 33977871 23541952 24034250 22082873 21543763 19347031 31696776 9765397 16713569 24879154 24141421 17446862 24472739 24599950 28431397 20577262 19050071 32820146 21358617 21139567 23479509
CTNNB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17404573 16288908 12782598
ESR2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19211725 18223478 20664923
PPP1CC BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 17274640 12051739
NELFB BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12612062 11739404 16713569
AKT1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21242970 10542266 20085797 19074868
CDK2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 16713569 10373534 9244350 8764100
BRCA1 MSH6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16260778 25184681 11498787 10783165
BRCA1 UIMC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21622030 17525340 25184681 17525341 17643121 29656893 19305427 26446986 25252691 26027929 28569838 19766185 19261748 34408138 29499138 19615732 17525342 17621610 31932421 24085845
EZH2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19079346 20574448
CASP3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12149654
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
AR CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22038727 20610535 23554843
NFE2L2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10510468
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
CCNB1 CDK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 34224728 18337751 9891079 24508230 17431037 9560267 14681455 17283331 8662825 19162005 16159883 25852190 20360007 19879842 12397081 11331587 9247342 26496610 20228808 25750436 12612082 16784539 23602568 20733055 27626412 20367638 8397206 10973963 9001210 20956543 33037310 8397207 23543736 32707033 2570636 30674583 10716937 27030811 18408765 24358021 20974803 7799941 33961781 26186194 17679094 23799914 8463339 26344197
RBL2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9891079 17531812 25852190 9472014 33961781 26186194 23602568 10825149 23455922 9188854
CDK2 SKP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7553852 26496610 25852190 33961781 9636170 23602568 16979657 23455922
CDK2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
OS9 EGLN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15721254 16391536
CSNK2B EIF6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FOXO3 RBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11884591 16493026
MAPK3 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19282669
AR IFI16 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16494870 20610535
MAPK3 PPP1CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
PGR SUMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19211567 17717077 17020914
AR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24119295 21796528 17932034
ESR2 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
TP63 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
TP63 CDC25C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19861536
AURKA PIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23970419
RPL13 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SUMO2 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CSNK2B LCK â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TFDP2 E2F4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 10090723 16360038 9501179 33961781 26186194
E2F4 RBL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17671431 21102443 12006580 9858615 17531812 9121766 9343408 17159899 11573202 23108140 22002537 20133863 16600870 12401786
E2F4 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16360038 9501179 8657117 7958924 7958925 10540350 27705803 9343408 24981860 9199321 7892279
E2F4 RBL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17671431 16360038 12150994 9501179 8657117 7958924 9233764 9858615 8832394 7958925 8643455 9343408 9724731 11573202 12401786
CDK4 E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
E2F4 CDC25C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799066
E2F4 DHPS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799066
E2F4 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15510213
RPL13 ILK â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
CDK4 TFDP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK4 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK4 RBL1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
USF2 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15208653
PPP1CA AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11039908 11551964
AR CTNNB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
USF2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15042619
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
ESR2 TFDP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
CCNE1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
SERPINB9 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10477277
TERF1 TNKS2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 11454873 11802774 11739745 12080061 33961781 26186194 10988299 22153077
USF2 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12917334 18165439
PGR CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21628418 18483177
TFAP2C ECM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24023917 17187826
PPP1CA PPP1R9B â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PPP1CC PPP1R9B â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CSNK2A1 SUPT16H â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
E2F4 PIN1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
CSTF1 CSTF2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
TOP1 TOP2A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
CCNE1 CDK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
RBL1 TFDP1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
RBL1 TFDP2 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 7739537 33961781
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
SUMO1 TOP1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12149243 12439742 11709553 24654937 15576338 19596686
ALYREF DDX39B â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
BECN1 BCL2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 19180116 7014480
BCL2 BECN1 â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 8095158 21139567
MDC1 TP53BP1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
SMARCC1 SMARCD2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
BLM TP53BP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
SMARCA2 SMARCD2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
ARNT SIM2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CCNB1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 20733051 28514442 9891079 7799941 8397207 25852190 26496610 33961781 26186194 23602568 10995390 23455922 30674583 18471975
RBL1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 9891079 33422522 25852190 11884610 9472014 33961781 26186194 23602568 8230483 8491188 23455922
CDK2 CCNE1 â—¼   PHOSPHORYLATION ✅ - 0.96 0.96 Signor 19561641
SUMO1 TOP2A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12832072 10862613 18381449 19596686
SUMO2 UIMC1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CHEK1 TP53BP1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
E2F4 RBL2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
ARNT SIM2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 27472814 9020169 14701734 9271372 33961781 11782478 27684187
E2F4 RBL1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CDC25C CHEK1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SMARCA2 SMARCC1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CSNK2B SUPT16H â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EIF6 RPL13 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CASP1 PYCARD â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CSNK2B CSNK2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 36833176
AHR ARNT â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CCNB1 CDK2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
EIF6 RPL31 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CDK2 CCNE1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 28137908 16431923 29439025 9891079 18559665 33854235 11940657 15004009 17431037 17361108 33854239 14681455 17254967 8867812 23853094 10827081 10330164 8662825 25852190 15557281 9192873 23455922 21092281 14536078 21372285 21241890 19631451 16223725 26496610 1388288 9716181 9472014 15980415 14701826 23602568 8978686 11433299 11132966 24771265 12839982 20587660 19470470 10359664 15514162 17970072 9840943 25728284 9660939 8647086 24358021 7799941 12529437 8756624 33961781 15670215 26186194 20837141 12800980
E2F4 TFDP1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
FBXO44 SKP1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
ARNT AHR â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 8065341 28514442 11768231 9704006 11259609 7488247 19380484 20006590 22138065 11025203 10617682 23477502 9887096 31675361 12024042 12139968 11551916 17392787 18096572 8384309 10619402 7628454 19390533 26350169 8631989 8621524 10671489 33961781 10395741 8619634
POLR1A POLR2H â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
RPL13 RPL31 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19651622 17081983 2183353 18691976 18452278 18669648
BRCA1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12919958 12024016 17352427
LCK ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16076903 16787943 17570479 11847100
ABL1 TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15448168 20841568
ABL1 PSMA7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16678104 25620702 20841568
ABL1 ERCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17626041 20841568 27827925
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
RPA2 ATRIP â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATRIP CHEK1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATRIP CHEK1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
MSH6 ATRIP â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
ATRIP CHEK1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
RPA2 ATRIP â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA2 ATRIP â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CDK2 ATRIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20195506 17638878
ATRIP BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24073851 17616665
BABAM1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19261748 19261749
BCL2 BECN1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10604474 11704864 16179260 17106237 17446862 17891140 18612260 22039431 22885520 23064052 23377657 23430059 23850759 27754749 8929532 9765397
BCL2 BECN1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10604474 11704864 16179260 17106237 17446862 17891140 18612260 22039431 22885520 23064052 23377657 23430059 23850759 27754749 8929532 9765397
AR BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17655826 11567031 23160675 20610535
PGR BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17785366 9306964
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
MAPK3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9115213 10669763 9735392 11323415 21785723 9738012 10677502 23272207 25826088
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
CDK1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24097825 24677263 23638364 19917720 27231850 11774038 11326318 10766756
MAPK8 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 12421819 26609913 17097560 16738310 21726807 10567572 21993018 29950132 20919655 22848813 15225643 19029119 9738012 18570871 9115213 12039864 11323415 15733859 18471544 15703383 23329792 10677502
BCL2 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 72.0 1.0 Omnipath 23504944 17643073 23168911 21971985 19273585 16713569 19050071 16179260 23316280 22205736 23115300 18641390 28128446 17446862 23954414 22241963 23541952 29955058 25891078 29849149 24034250 24599950 9765397 25984893 21358617 18570871 16799551 19180116 20889974 20622903 23564079 19959994 20711182 23479509 19347031 20010695 21543763 22622204 24472739 17438366
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM POT1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 23253856 24089143 24095737
BLM FANCI â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM FANCD2 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
CHEK1 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21050475 20719863 25015292 25906194 15364958
TERF1 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 15229185
BRCA1 AURKA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 UIMC1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 FANCI â—¼   PHYSICAL_INTERACTION 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCD2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 AURKA â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 UIMC1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 FANCD2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCI â—¼   SHARES_COMPLEX 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
BRCA1 AURKA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
BRCA1 CHEK1 â—¼   REGULATES ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
E2F4 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20133863 21701264 17531812 17001309 20818429 17106239 23108140
BRCA1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16940443 19445691 22787115 21087664
BAP1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 9528852
E2F4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9244350 18319725 16713569 12909625
UIMC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17525341 17525342 17525340 17621610
ABRAXAS1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17643122 19261749 22357538 17525340 19261746 21282113 19261748 25184681 17643121 19305427 23416467
CDK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8764100 10373534 10550055 19683496 16713569 26719576 15212693
AURKA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22864622 22340593 18026198 24775809 14990569
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
CDK1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9244350 21706030 10550055 17570479 19683496 16713569 26745677 32193285 26719576
CDK4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9244350 16713569 17334399 20932174
PPP1CA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 25056273 12438214 17511879 17603999
BRCA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11085509 16713569 11016951
BRCA1 FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12887909 12485996 11239454 25652403 14499622 16713569
CASP3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8626669 9535906 16713569 9208847
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CSNK2A1 CBX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19657222
CCNB1 CDK1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
LMNA CDK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 22986494 2188731 2344612 2188730
CDK1 CDC25C â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 1075565 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17568790 17596790 17660363 18073536 18414028 18543256 18590585 18786381 18995830 19652693 19686080 7575488 9892021
CDK1 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17243194 17303408 17660363 18414028 18590585 7575488
CDK1 TERF1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 14551205 15279786 17303408 17660363 18414028 18590585 18625707 22624377 7575488
CDK1 RPA2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
E2F4 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15510213 17671431 11799067 11032828 17121828 17531812
TP63 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11593387 19861536
E2F4 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15510213 16135806
CDK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 7575488 18590585 17243194 17303408 21524151 17570479 25607646 29603287 20126263 17660363 30685087 15279786
CDK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 17274640 22367880 18088087 17202132 9122166 97225924 10880350
CDK1 APLP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14970211 9109675
CDK1 CSNK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16335537 1939094 19007248 17081983 25788269 18691976 20230923 20068231 19387552 17570479 12551973 12396231 19581576 7578274 18669648
CDK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 26573794 12569365 22275373 25704883 17043241 23321516 9725910 24480624 21799006 24424504 28062857 21820033 25950519 28415597 27450452 25691442 21782001
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9139719 17303408 9295339 19793801 15279786 7575488 20068231 17116885 19671522 17582221 26237679 18590585 1318195 22977173 17660363 20932174 17296725 17102137 21664290
CDK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7592773 30392930 18691976 19387552 20068231 96029687 16371510 1400350 19941816
CDK1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17349584 17110335 17303408 18073536 1075565 11836499 15279786 8348613 7575488 20668692 24710276 9733650 12036951 20068231 8440392 12742231 32075732 16189514 9141461 16123593 18669648 19652693 18590585 9585407 12814430 10864927 10373560 18691976 11313986 12124778 18786381 17660363 18272572 8119945 15917306 27038604 9268380 17596790 28396830 17568790 19350548 16964243 10037602 18212344 12478465 12766774
CDK1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 25841987 34381492 25691891 27941792 27653691 23549878 25800736 22187039 23241245 25038756 25334066 22964433 27716745 20935635 21131960 29576612 33593912 21123648 23438432 21659531 26552009
CDK1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23799914 34224728 20117088 16784539 24358021 24508230 19470789 10973963 17283331 20228808 18347064 11242082 12397081 10362260 24582498 15582998 20367638 1833185 12447691 9001210 2570636 24101512 23543736 11331587 12524548 22726437 27626412
CDK1 LMNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 19007248 16565220 20166139 17081983 18767875 20393185 23870088 17137347 19413330 18187866 19194518 30190500 19664995 19415658 15302935 7925482 16083285 95010153 24741066 20068231 18452278 18077418 17570479 18491316 18669648 32071079 23427156 2344612 18691976 26922519 17287340 18815303 20068230 19651622 20058876 19691289 17924679 22367880 19165338 19664994 18707149 21389115 16964243 18212344 24556839
CCNE1 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK2 RPA2 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
E2F4 CDK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 22447046
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
SKP1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7553852 23602568 16979657 9636170 26496610 25852190
CDK2 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 43.0 1.0 Omnipath 8662865 15572662 17717077 26577046 7476977 20116396 24291072 10628747 24333793 11509655 21945472 21447625 29301281 27852068 25252652 22809143 18202149 18088087 15798179 19118566 9171245 10655479 11110801 15601848 28412963 19706513 22697792 12529413 15212693 19904813 24302725
CDK2 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 14715909 17274640 16550609 18088087 17570479 9122166 97225924 15212693 10880350
CDK2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20935635 25800736 29576612 23241245 32368395 29556394 17570479 27863310 26279746
CDK2 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20857408 17570479 11042701 9188854 11157749 12006580 15212693 10825149
CDK2 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20530684 28396830
CDK2 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21765472 21965652 21907702 18983824 24242917
CDK2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 17145710 16223725 21092281 15004009 10962581 9840943 8643455 24358021 8861947 21372285 17570479 11237742 10330164 22558078 10652300 19561641 10477583 18691976 23853094 12144826 10500095 1388288 10827081 17970072 28137908 19470470 8756624 10809788 14536078 15364936
CDK2 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21602882 18769144
CHEK1 RPA2 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 FANCI â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 18931676 19686080 19793801
CHEK1 FANCD2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14988723 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 18931676 19686080 19793801
CHEK1 CDC25C â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17568790 17582221 18677104 19793801 20126263
CHEK1 RPA2 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA2 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
AKT1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20832017 18691976 23108403 17418864 20068231 12062056 15107605 17570479 19664995 18669648 26091525
CHEK1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 29774099 17145710 10391675 18321553 29425806 10214922 20716119 18677104 20860841 15798197 19793801 11836499 10681541 21152443 12505356 27603133 24505404 11333986 9836640 11551930 17097061 23880065 15736430 26485758 11240139 9889122 20068231 17116885 12742231 28442587 17582221 20126263 14681223 9278511 17384638 15629715 12814430 11313986 11741534 20068082 24079846 26542114 9278512 9659898 15705874 11027648 24525428 9914179 10557092 15459660 10676638 9810229 15150265 10209160 17296725 15296723 25512053 12399544 21035467 9543386 9744884 19490919 28396830 17102137 17568790 16488126 16330544 12478465
CHEK1 FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17296725 19686080 22057367 19861535 18677104 15798197 17102137 17116885 17582221 19793801 14988723 17384638 18931676 15459660
AKT1 CLK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20682768
FANCD2 FANCI â—¼   PHYSICAL_INTERACTION 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCD2 FANCI â—¼   SHARES_COMPLEX 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
UBE2T FANCD2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12239151 16916645 18931676 19264559 19622404 19686080 20457011 22615860
E2F4 FANCD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 11799066
UBE2T FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18931676 22615860 12239151 19622404 17768402 19686080
FANCI FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21719678 22855611 24451376 17460694 27773793 20603015 25168188 19561358 18931676 24623813
UBE2T FANCI â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17938197 24905007 24623813 19589784 24726325 16916645 24389026
UBE2T FANCI â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12239151 16916645 18931676 19264559 19622404 19686080 20457011 22615860
UBE2T FANCI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18931676 22615860 19622404 17768402 19686080
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
FOXO3 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16061480 17522055 18687691
CTNNB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 15905404 21071413 17254970
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
CSNK2A1 IFI16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11115400
MAPK3 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938135 17088940 16093479 16613989 11467847 7791761
MAPK3 GTF2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10648599
MAPK3 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8506364 8618896 8226850 7597029
MAPK3 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12529413 10655479 10628747
MAPK3 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 9020136 9130707 26028036
XRCC5 MDC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MDC1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
MDC1 TP53BP1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
CSNK2A1 MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20711462 20507565 19118383 18411308 21576760 18678890 18583988 15066279 20471329 19230643 21592330 21118972 18006705 20533398
MDC1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16009723 17145710 18087291 17925396 12607005
PLK3 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 14968113 19622404 10681541 11551930 11333986 9836640 10744722 19686080 19270156 20068231 16189514 15791647 9278511 15629715 19607708 12941695 9278512 10557092 27038604 15150265 9543386 17596790 11897663 18931676
PLK3 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18062778 17081983 18669648
PPP1R9B PPP1CC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10194355 24366813 26186194 28330616 23080069 10391935 26496610 25785436
CASP1 PYCARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 24630722 25605870 12191486 15383541 11051551 11967258 11536016 24803432 21385879 26121674 11432859 12019269 16585594 19337385 14634131
POLB RPA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
AR SMARCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535 17721441
AKT1 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17570479 16568092
TOP1 SUMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12149243 11709553 25114211 10759568
SUMO1 ZNF350 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17942393 17079232 25114211 18488044 17298944 18082607
TOP2A SUMO2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24782567 17183683 18381449 25114211
CSNK2A1 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 19007248 16565220 17081983 18767875 19664995 15302935 10942766 19098900 20068231 18452278 7499337 9761967 18669648 8939955 18691976 17287340 19651622 20058876 19691289 9804834 19664994 11940573 7961967 16964243
UHRF1 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10646863 12530060
XRCC5 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53BP1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
TP53BP1 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
TP53BP1 UIMC1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
CSNK1D UHRF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23297342
PPP1CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
PIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16713569 11533658
CSNK2A1 CSNK2B â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CSNK2B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12432063
CDC73 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 16630820 23331499 21726809 18988627 29774127
E2F4 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 15855772 22508987
E2F4 BORA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 15033491
RBL2 E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22002537 16600870 17671431 9858615 15838517 9121766 11573202 20133863 8657117 17531812 17159899 9144196 12006580 23108140
E2F4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12150994 17671431 9858615 7958925 11573202 7958924 18319725 8657117 9724731 9144196 9501179 8643455 10766737 16135806 16360038
MAPKAP1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MAPKAP1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19203586 15718470 19568798 15169778 19720745 17517883 18925875 10949026 11715018 19143635 17277771 18636226 16962653 9812896 19844585 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
CCNE1 SKP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
SKP1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
NFE2L2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24466341 17640564 18588981 15655294 22951256
NFE2L2 ABCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18038766 17003472 14550278 23667609 19638449
ILK AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11546794 14500673 12176337 11445557 15899889 23840605 9736715 12149249 10592173 11313365 16189514 19460343 11278835 15212693 18772455 10226025 11825911
AR IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19318566 15033751 17202144 19250214 20610535
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
CSNK2A1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 29732088 17374729 21506126 11689703 10671551 12149249 15818404 10747897 10837139 20976471 19662498 21285348 11035045 11707428 21735093 17444818 20558317 11972058 16707567
PPP1CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938135 17088940 16093479 16613989 11467847 7791761
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 ALYREF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18562279
CDK4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 10498883 17303408 16236519 11884610 8643455 19664995 15279786 7575488 10385618 9736735 19075565 12006580 18590585 20068082 17495531 18786381 17660363 19664994 10069453
CDK4 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10498883 10385618 9736735 11157749 12006580
CDK4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
PRKG1 GTF2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16055503 12082086 19651622 20068231
PPP1CA CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9543386 14592972 11897663 16467385
MAPK8 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12742231 20220133 8119945 7513216
CSNK2A1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15064744
MAPK8 AIMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20510162
LMNA CCNB1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 22986494 2188731 2344612 2188730
CSNK2A1 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18347021
CSNK2A1 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16129408 18669648
CSNK2A1 ABCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22695718
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
AR CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18535113 18673534 20610535 11916967
AR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 21741601 16713569 12799378 12944908 10809237 23331499 15060161 21071413 21885566 18988627 16428447 11916967 12588987 11792709 10987273 14593076 15256534 22187462
CSNK1D CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10488109 9312064 23331499 11955436 9482734 14966280 10023673 12000790 11818547 12114015
AR CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11427738 12600681 10940736 2289019 17520059 20610535
AR KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17433535 8626436 11059779 15640443 7686046 11006269 12111703 15368351 24307657 9316650 9719026 11867260 12376473 14767470 16275987 11994312 17075604 20181722 9211894 16342680 12917209 18092350 12648523 17011549 11238180 20069563 10547578 16140973 22245379 12539223 20568894 20103546 18758709 21981678 21541973 12463425 12958311 11894840 19389135 17534890 23662037 15923603 16434977 14517289 22695118 10075669 11377978 16137620 11299734 15131260 21780100 16508948 16425097 22473899 14715080 10625666 18640093 21885566 12670590 14729601 16452400 16081584 10898343 11571582 9044850 15833875 16914734 23884959 15640095 15543614 7514587 12376534 12114445 15557561 18780293 23667504 18829551 12782640 16724108 17426252 11504717 19274665 11034093 17566103 12651911 22179832 21308712 16373397 19013180 22155408 9052414 11532861 17094454 17653089 20709811 22654108 22597536 15514031
NRIP1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9368054 16527872
CASP1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9535906 16713569
MAPK8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24424504 21512132 21820033 16282370
AR KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1712248 19345326 25241761
MAPK8 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 9020136
MAPK8 APLP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15212693 14970211 9109675
PRMT1 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17053781
CSTF2 CSTF1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24149845 10357856 10669729 10371034
ESR2 PGR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16293641 12761896 11014241 19001520 9717846
ARNT AHR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 8621524 8384309 9887096 20006590 10395741 18096572 12024042 7628454 9704006 19380484 17823304 11259609 19390533 22138065 8631989 8619634 8065341 11768231 7488247
TFDP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18687693 14618416 12029633 10756032 24335704
RBL1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8643455 18319725 8230483
SIM2 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14701734 11782478 9271372 9020169
TFDP1 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7958925 12150994 7739537
RBL1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7958925 12150994 7739537
TNKS2 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12080061 26186194 11739745 11454873 22153077 10988299 11802774
UBE3A PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 9891052