JAK1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5213490
11163768
|
BRCA1
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11001824
19223505
|
FANCD2
|
BRCA1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
11239454
5213674
|
MTA1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17922032
|
MAPK1
|
CLTC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10608864
10818153
|
DNAJA1
|
TRAF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
GRB2
|
DNAJA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
E2F1
|
HMGA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22389255
|
E2F1
|
FANCD2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18438432
|
E2F1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18396012
|
MAPK3
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14967450
22802261
|
EGFR
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16299810
|
STAT3
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6731598
14966128
|
PLCG2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
EGFR
|
ATP5F1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
EGFR
|
IRS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
EGFR
|
NRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
KRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
PTPN1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
9355745
6671413
|
TP53
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
EGFR
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
FANCD2
|
TRAF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
PTPN6
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10660620
6671678
|
PLCG2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
ID4
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
GRB2
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
DUSP15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
GRB2
|
SERPINH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
MAPK3
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8994038
|
SRC
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
MAPK1
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
RAF1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
NFATC1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19661463
17239241
|
ESR1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23250869
22430216
|
PTPN7
|
MAPK1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6672848
10415025
|
FGF2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9490736
12750158
|
HGF
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16397249
17667909
|
MAPK1
|
XPO5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
27846390
|
SRC
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
MAPK3
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK3
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
TP53
|
MAPK3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21187340
16050810
|
HGF
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16397249
17667909
|
EGF
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17081983
16024629
|
MAPK3
|
XPO5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
27846390
|
MTOR
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
MTOR
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
AKT1
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17611497
18954143
|
TP53
|
NFATC4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
14990988
|
NFATC4
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16219765
17194453
|
YWHAB
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217174
15324660
|
HGF
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9094433
9440692
|
STAT3
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
STAT3
|
PGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
23042533
|
STAT3
|
PDGFB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7876144
8662928
|
STAT3
|
VEGFB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16899623
21731766
|
STAT3
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
15821101
6673264
|
TP53
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18812399
8008642
|
TP53
|
HLA-A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15501971
12857899
|
TP53
|
FN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15230856
8732672
|
TP53
|
PRL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16227626
9806359
|
TP53
|
TGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7651386
11668476
|
TP53
|
MTA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23552838
22286760
|
TP53
|
RPL11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21097889
22467867
|
SYVN1
|
TP53
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17170702
5219455
|
XPO1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17268548
17891139
|
TP53
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10766163
16713569
|
TP53
|
HGF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
TGFA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7915517
|
TP53
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TUBB6
|
TRAF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TRAF6
|
ARRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0906941106
19955404
|
NFATC1
|
TRAF6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17092936
17239241
|
FGF9
|
FGF10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
8663044
|
VAV3
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
INSR
|
VAV3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11094073
|
SOCS3
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
SOCS3
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
11331873
|
VEGFA
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11387210
11600407
|
VEGFA
|
SHC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10749680
12214271
|
VEGFA
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15026417
9182576
|
ITGB3
|
ITGAV
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214491
11546839
|
ITGAV
|
SERPINH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SOS1
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9544989
6547749
|
SRC
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10964917
8755247
|
IGF1
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8033892
7559507
|
SHC1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6805769
9593725
|
RASA1
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8155326
|
HRAS
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17138645
|
PTPN6
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8541543
|
JAK1
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
9670964
|
EGF
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
17673906
|
SRC
|
HGF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
17574028
20802513
|
HGF
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10521801
16782899
|
PDGFB
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15845350
12753909
|
YWHAB
|
ITGB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5213955
11313964
|
FN1
|
ITGB1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21985969
8208414
|
SRC
|
CSK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16005629
15157149
|
ERBB2
|
CSK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6730868
9461599
|
PTPN6
|
CSK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
18173375
18759926
|
CSK
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16678999
6731761
|
ITGB3
|
CSK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10592173
11940607
|
RASA1
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6805619
9020117
|
DUSP15
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
FGF19
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16844695
10652257
|
SOS1
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PLCG1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
200301131
14568990
6804839
|
PLCG1
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20808760
1000457
|
PLCG1
|
DUSP15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PLCG1
|
ID4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PLCG1
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16844695
10652257
|
PLCG1
|
INSR
|
â—¼ COLOCALIZATION
|
✅
|
|
0.8
|
0.8
|
mint
|
200301131
14568990
6804839
|
RASA1
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9020117
9743338
|
MET
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8662733
7513258
|
SRC
|
PXN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15574420
14665621
|
PXN
|
FN1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21985969
8208414
|
SIRPA
|
PTPN6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10660620
6671678
|
CAV1
|
PTPN6
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
12176037
6731969
|
ESR1
|
PTPN6
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6673088
7539106
|
JAK1
|
PTPN6
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8943354
18508557
|
PTPN6
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12220225
|
JAK1
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
ERBB2
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273093
|
TIMM50
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216198
12620389
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
RASA1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5221569
9219684
|
HRAS
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
12695509
5216326
|
HRAS
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8621645
5220985
|
HRAS
|
HSD17B12
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HRAS
|
EGF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
HRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
ERBB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
RASA1
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6731661
15504032
|
RASA1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6805769
9593725
|
PIK3R2
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217174
15324660
|
DUSP15
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
SOS1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
SRC
|
ID4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
SRC
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6731430
11940572
|
SRC
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16432186
0510562103
|
SRC
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6672010
16291744
|
PTPN1
|
SRC
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6732073
9600099
|
PTPRF
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
12176037
6731969
|
PTPN1
|
CAV1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
12176037
6731969
|
CAV1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15976327
|
KRAS
|
EGF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
NRAS
|
EGF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGF
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
17673906
|
EGF
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20178463
17081983
|
FGF2
|
FGF9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
18552176
18757403
|
FGF2
|
FGF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
18552176
18757403
|
ARHGEF12
|
IGF1R
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
11724822
5214835
|
IGF1R
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
7541045
|
IGF1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19183465
12875741
|
IGF1
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23518924
32196115
|
EWSR1
|
IGFBP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
21531709
15282325
|
ESR1
|
IGFBP4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14605097
|
ESR1
|
IGFBP4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18414489
|
PTPRF
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15896785
|
ITGB3
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16005629
16115959
|
ITGB3
|
PTPN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16115959
|
FN1
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11476890
16919435
|
FN1
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16005629
16115959
|
MET
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10521801
16782899
|
STAT5B
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9428692
6730856
|
STAT5B
|
INSR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10830280
15055356
|
KLF6
|
INSR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15131018
24281069
|
INSR
|
PTPN1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
11506178
6671880
|
INSR
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12456798
|
ERBB2
|
IRS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
ERBB2
|
PLCG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
KRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
NRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
ERBB2
|
SHC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273093
|
ERBB2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11173924
16713569
|
WT1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18708366
16087727
|
ESR1
|
HOXC6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21683083
18414489
|
ESR1
|
STC2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17486082
18414489
|
ESR1
|
HSP90B1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16511840
23038705
|
ESR1
|
WT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18708366
16087727
|
ESR1
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6673088
7539106
|
PRL
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25193864
19524120
|
STAT5A
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
12237455
6671710
|
PTPN1
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18579758
6731904
|
PTPN1
|
STAT5A
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
12237455
6671710
|
PTPN1
|
MET
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6764906
16537444
|
STC2
|
ARRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
PIK3R2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
9651378
|
PELP1
|
MDN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21326211
8149485
|
PRL
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19262752
10358079
|
PBX1
|
FGF8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10026229
|
EWSR1
|
HMGA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
HAX1
|
XPO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23164465
8401898
|
WWP1
|
EWSR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
FGF6
|
FGF9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
18552176
18757403
|
STAT5A
|
A2M
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8825557
7519723
|
UGGT1
|
UGGT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
MAPK3
|
PTPN7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
RPL11
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
ERBB2
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
805.0
|
0.8
|
STRING
|
36370105
|
GRB2
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
808.0
|
0.8
|
STRING
|
36370105
|
ESR1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
1204073
5215931
11244506
|
PTPN12
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
28065597
|
MAPK1
|
PTPN7
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.81
|
0.81
|
Signor
|
16226275
|
MTOR
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
10660304
24931163
23329839
15522880
|
JAK1
|
SOCS3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
10707961
10373548
|
PTPN12
|
SHC1
|
â—¼ PROXIMITY
|
✅
|
|
0.81
|
0.81
|
mint
|
27880917
|
PLCG2
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
22973453
16273093
25241761
|
ITCH
|
TRAF6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
813.0
|
0.81
|
STRING
|
36370105
|
ESR1
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
818.0
|
0.81
|
STRING
|
36370105
|
IRS4
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24797263
16273093
|
EGFR
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17047074
17307140
|
GRB2
|
CSK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31980649
21706016
|
ARRB1
|
TRAF6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16378096
19879840
|
ERBB2
|
INSRR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
30898150
|
SHC1
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.82
|
0.82
|
mint
|
16729043
5218694
|
INSR
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
9121430
10482988
8702728
7559507
12237775
9446569
11075717
9710204
10803466
10896916
9741627
10921922
9593725
10816433
9083103
15629149
7499194
10764799
|
SHC1
|
SHC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
AKT1
|
CSK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26344197
19262695
|
SEL1L
|
OS9
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.82
|
0.82
|
mint
|
29496332
|
IGF1R
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17307140
30898150
|
ARRB1
|
ITCH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17947233
18544533
|
KLK5
|
OS9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
OS9
|
TTC17
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
INSR
|
HACD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30300385
25687571
|
ESR1
|
HYOU1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19805454
25604459
|
FGF9
|
FGF20
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
JAK1
|
STAT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
823.0
|
0.82
|
STRING
|
36370105
|
CXCR4
|
ITCH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
823.0
|
0.82
|
STRING
|
36370105
|
KRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
EGFR
|
STAT5B
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
11751923
|
SOS1
|
KRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
25624485
|
LYPD3
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
ARRB2
|
TRAF6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
19955404
16378096
25425640
|
OS9
|
GGH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
22119785
28514442
26186194
|
SHC1
|
PLCG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
12135708
10623845
|
CSK
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
10753943
19262695
|
RAF1
|
CALU
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
31980649
26496610
25852190
|
OS9
|
SYVN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
21454652
26424800
28827405
19084021
23097496
22119785
32614325
18264092
|
YWHAB
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.83
|
0.83
|
mint
|
9581554
6547842
|
ARRB2
|
SRC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
19202075
19122674
11877451
23242524
|
ARRB1
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
33158816
15878855
21685939
|
RCN1
|
RNF41
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
PGF
|
VEGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
830.0
|
0.83
|
STRING
|
36370105
|
AKT1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
BRCA1
|
FANCD2
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
12485996
|
ARRB2
|
CLTC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
ESR1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
KIAA1244
|
PHB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
MTOR
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
ESR1
|
MTA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
PTK2
|
SOCS3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
PRKDC
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10608806
25223785
|
RASA1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
16189514
12441060
16713569
|
INSRR
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
33961781
8916919
|
ARRB1
|
SRC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
33844281
19202075
16432186
23242524
|
PDPK1
|
FGF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32707033
31980649
|
ESR1
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10749889
24051437
14764897
28555617
16113100
|
EGFR
|
PLCG1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.84
|
0.84
|
Signor
|
1689310
|
ARRB2
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
INSRR
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
841.0
|
0.84
|
STRING
|
36370105
|
MTA1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
EGFR
|
SHC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
MAPK1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
ITGAV
|
ITGB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
PLCG1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
9020117
6805619
|
SHC2
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
8610109
16273093
24430869
22973453
|
SRC
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
16189514
16713569
11964172
9016807
12624098
|
VEGFB
|
VEGFA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
25241761
8702615
33961781
26186194
|
PLCG1
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
8662733
8155326
10652211
|
SRC
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
1689310
7510703
16713569
7682059
8657103
8885868
|
PLCG1
|
RASA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
9020117
8977179
9743338
|
RASA1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
22973453
16273093
24412244
|
SRC
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
17284441
6169640
|
ERBB2
|
GRB2
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.85
|
0.85
|
Signor
|
14967450
|
INSR
|
INSRR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
851.0
|
0.85
|
STRING
|
36370105
|
INSR
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
853.0
|
0.85
|
STRING
|
36370105
|
TP53
|
XPO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
IGF1R
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
JAK1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16713569
11163768
|
VAV3
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
24797263
10938113
11094073
22973453
25754235
|
IRS4
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
21706016
9553137
|
ESR1
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
23874500
11429412
|
TRAF6
|
SRC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10635328
16189514
22447928
29545793
|
PCNA
|
CALU
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
22863883
26030842
|
MET
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
8662733
24728074
7513258
|
INSR
|
RASA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
1331107
9593725
|
PELP1
|
SRC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
14963108
15466214
12415108
|
CAV1
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10598578
31217420
|
INSR
|
IGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26027733
8452530
|
MAPK1
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
AKT1
|
APPL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
EGFR
|
SH2B1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
TP53
|
WT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
867.0
|
0.86
|
STRING
|
36370105
|
PTPN6
|
SIRPA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
RPL11
|
SEC61A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
EGFR
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
PTPRF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24797263
31980649
24189400
|
EGFR
|
ARRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
STAT3
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
22693070
|
ESR1
|
PHB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10938099
24051437
12943695
26052702
17932104
19805454
28555617
10359819
15140878
|
PELP1
|
MDN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
21326211
22939629
|
ITGB1
|
PXN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
IGF1
|
IGFBP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
EGFR
|
VAV3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
21779497
|
ESR1
|
PHB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
PTPN1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
MAPK1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
FN1
|
ITGB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
PTK2
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
PTPN1
|
IGF1R
|
â—¼ DEPHOSPHORYLATION
|
✅
|
-
|
0.87
|
0.87
|
Signor
|
11884589
|
ESR1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16713569
28065597
20935677
11887937
17284441
|
JAK1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
11527382
8536716
|
NISCH
|
IRS4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
25036637
11912194
|
AKT1
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
15678105
15262962
|
SOCS3
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
11071852
15514089
12560330
|
SHC1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
CAV1
|
CSK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
11805080
24632723
16678999
|
SRC
|
RASA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
1717825
11389730
16189514
16713569
|
SMURF1
|
SMURF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
CAV1
|
PTPRF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
34079125
12176037
|
ARRB2
|
ITCH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
17947233
18544533
|
PELP1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
14963108
21182205
11481323
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
CAV1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
STAT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
GRB2
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
YWHAB
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
PRKDC
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
SRC
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
HSP90B1
|
OS9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
IGF1R
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
ERLEC1
|
SYVN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
ITGB3
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
JAK1
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
SH2B1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
16273093
25402006
31980649
|
EGFR
|
SHC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31980649
28724758
22973453
24658140
24430869
25402006
|
EGFR
|
RASA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
1633149
22973453
1385407
8647858
16273093
1850098
|
EGFR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
25402006
31980649
|
MAPK1
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
RPN1
|
RPN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
32788342
33961781
34079125
22939629
26344197
|
PTPN12
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
IGF1R
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
7559507
24051437
8776723
7541045
14764897
15629149
16113100
|
SHC1
|
CSK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10037694
19380743
12048194
|
SHC1
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
7731718
24728074
9660480
|
CSK
|
SRC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12387813
17525734
9208935
7678701
21746865
7513429
|
RAF1
|
YWHAE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
SRC
|
CAV1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
8910575
8632005
8621645
29720121
|
SOCS2
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
29559623
9727029
|
INSR
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
890.0
|
0.89
|
STRING
|
36370105
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
EGFR
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
ITGB3
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
EGFR
|
RASA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
895.0
|
0.89
|
STRING
|
36370105
|
ERBB2
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
ESR1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19887647
1244506
11782371
15674350
29367421
27977889
17392432
16860316
10334989
16260778
11244506
16061635
12400015
17505062
20060929
25499220
16713569
31527615
11493692
|
AKT1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21242970
10542266
20085797
19074868
|
E2F1
|
VEGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
20639906
16835303
|
PTPN1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.9
|
0.9
|
mint
|
6671413
9355745
|
SRC
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.9
|
0.9
|
mint
|
17284441
6169640
|
TGFA
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8663070
31980649
12297049
24658140
28988771
25402006
10775655
|
SOCS3
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24658140
25402006
31980649
12070153
|
PLCG2
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
31980649
22973453
24658140
16273093
25402006
|
EGFR
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20624308
24189400
21918175
24362532
10722725
23866081
26551075
|
EGFR
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
1689310
11983899
14568990
15144186
12803489
12601080
24797263
9756944
9207933
19605547
7993895
7693694
9020117
12061819
16273093
25754235
16713569
22973453
7682059
8657103
8885868
|
EGFR
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
31980649
23956138
20145033
21573184
25402006
15485908
15657067
14966128
9756944
18258752
15284024
24189400
24240702
25754235
24135280
15950906
24658140
12873986
20067773
10358079
|
EGFR
|
CSK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24797263
31980649
24658140
25402006
16729043
|
EGFR
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11500850
25241761
30898150
17486068
11526509
9461599
23866081
17426253
10572067
11500516
24557338
8665853
15657067
19060928
16516204
19650109
20211985
25315821
23436906
21278786
25898135
32669362
1346931
24189400
21044682
18803307
16843263
28369073
7531698
16713569
17148612
21203579
17307140
1706616
16207817
7797556
12354693
11408594
|
EGFR
|
CAV1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16407214
19446582
22411794
31980649
12388423
24658140
15273741
25402006
16799092
9374534
34079125
12354760
10781609
15657067
|
STAT3
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18367518
21590492
23504318
|
PTPN1
|
EGFR
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.9
|
0.9
|
mint
|
6671413
9355745
|
PTPN1
|
EGFR
|
â—¼ COLOCALIZATION
|
✅
|
|
0.9
|
0.9
|
mint
|
6732094
9050838
|
EGFR
|
PTPN1
|
â—¼ COLOCALIZATION
|
✅
|
|
0.9
|
0.9
|
mint
|
25796184
|
EGFR
|
PTPN12
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
21376233
7542744
7541030
|
EGFR
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8524316
15284024
|
ITGB3
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12005431
9566877
7997267
|
PDGFB
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
PDGFA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
MET
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11063574
15546961
9660480
19433454
21222362
7511210
8662889
11439336
|
VAV3
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
32296183
18654987
12577067
11094073
21706016
20936779
|
SH2B1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9742218
32296183
9856458
|
HLA-C
|
GRB2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
11513144
21339333
9605119
|
FN1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18624398
19738201
|
JAK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8536716
11527382
|
IRS4
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9553137
15316024
|
RASA1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12441060
16713569
|
MAPK1
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
27503831
16939974
9560161
|
MAPK1
|
PTPN7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
MAPK1
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16231973
12459785
23109003
|
MAPK3
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
27503831
16939974
9560161
|
FGF2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9490736
29436393
12750158
|
MAPK3
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15930121
|
MAPK3
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16231973
12459785
23109003
|
MTOR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
18566587
25792870
15718470
14970221
24670654
10910062
18505677
29567957
22337773
21177249
26293922
19299511
18566586
30639242
21045808
11438723
22084251
23872070
21343617
22307628
|
ERBB2
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20876300
11940572
16273093
19372587
|
SRC
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
21573184
15313931
11294897
8657134
18070987
10918587
12244095
19372587
12626508
8626374
14551213
16713569
8272872
11350938
9566874
12576423
11940572
15735682
|
STAT3
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21546410
|
STAT3
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16107692
23874455
20043094
|
PTPN6
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18508557
15870198
10545526
|
TP53
|
ID4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19500415
19783986
21293053
|
TP53
|
GGH
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16980608
|
TP53
|
SYVN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16980608
|
TP53
|
FGF2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
8090761
10029407
|
TP53
|
HGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17216187
18431400
9023107
|
SOCS3
|
TRAF6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18055217
16543409
|
TRAF6
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
34938598
19713527
|
SOCS3
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
ESR1
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16055089
18414489
|
STAT5B
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10821852
16306356
10359822
|
ITGB3
|
VEGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12820653
19267251
17030947
|
ITGAV
|
VEGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12820653
19267251
17030947
|
SRC
|
VEGFA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
15879121
20807769
11600407
|
SHC1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9710588
9019162
16713569
9756944
22973453
24658140
10085134
28065597
30898150
16843263
16273093
16729043
8665853
|
SHC1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20935677
11773443
16713569
|
PDGFC
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12767520
17496910
17673906
|
ITGB1
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19889638
10964917
|
PDGFD
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12767520
17496910
17673906
|
PDGFA
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12767520
17496910
17673906
|
MET
|
HGF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17804794
18593464
15167892
1846706
28628118
1655405
19433454
20624990
18495663
16537482
22897854
28205554
17981115
8380735
|
PIK3R2
|
PDGFB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFB
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
PDGFB
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
1396585
8443409
9739761
|
PDGFB
|
RASA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
1375321
1314164
9739761
|
PLAU
|
ITGB1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
18633355
22470492
27216177
|
PTPN1
|
ITGB1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
intact
|
201095
21806020
8287447
|
AKT1
|
ITGB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16256741
10896934
|
SRC
|
ITGB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10592173
11723131
11259684
|
FN1
|
CSK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16040750
14754902
10446041
|
EGF
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
8940074
1672440
10473558
|
PLCG1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22973453
16273093
1676673
1683701
|
SRC
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
15879121
20807769
11600407
|
INSR
|
PLCG1
|
â—¼ COLOCALIZATION
|
|
|
3.0
|
0.9
|
intact
|
200301131
14568990
6804839
|
EGF
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23613900
17081983
16525023
|
HLA-C
|
PTPN6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
ACSN
|
11513144
21339333
9605119
|
PTPN6
|
STAT5B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12220225
9211920
|
YWHAE
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.9
|
0.9
|
mint
|
8005785
11697890
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
SRC
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17097642
16189514
7517401
8876196
10205168
|
INSR
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
1331107
9593725
|
FN1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16040750
14754902
10446041
|
SRC
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24498420
14766010
15604093
11013076
27420286
29720121
12736255
18451880
15140878
23065768
17043237
17627277
7539106
11032808
17363140
20935677
14963108
11564893
12630920
22328528
15020686
15784253
17921256
24051437
10454579
17400812
17284441
16957778
|
SRC
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22973453
11940572
17875712
19372587
21075308
29720121
7542762
7797556
19704002
|
SRC
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24034250
20624308
9837958
24728074
|
ESR1
|
SRC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20160136
20460377
22865929
|
SRC
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
30644389
26854235
9096340
|
PDPK1
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
9368760
11825911
14500673
10698680
31467278
12149249
27563096
11313365
11278835
22569334
26264872
10226025
32876514
26256536
21775285
11438723
11445557
23397142
|
CAV1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11563984
23634843
22230296
19595769
|
ESR1
|
CAV1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12138116
18414489
|
STAT5A
|
EGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18996136
12697691
21617857
|
EGF
|
PTPN12
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
21376233
7542744
7541030
|
EGF
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17496910
1334406
19531499
|
CXCR4
|
ITCH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19116316
34927784
24489825
28264927
22275353
|
IGF1R
|
IGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
26027733
21645859
8452530
|
KLF6
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15131018
18174288
|
WT1
|
IGF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9076342
7791758
|
SH2B1
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9742218
10594240
15767667
|
MTA1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16807247
31527615
12167865
12639951
11146623
18451880
|
STAT5B
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11731618
11682625
|
ESR1
|
FGF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15781986
14999240
15311216
|
ESR1
|
PELP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19605405
15087130
|
ARRB2
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
24069330
17353931
33961781
17620599
|
PDGFA
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
PIK3R2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
SOS1
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25624485
23331499
16293107
|
PIK3R2
|
PDGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
STAT5B
|
SOCS2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20702579
16293640
10630411
|
PBX1
|
CYP17A1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9390195
7913464
9028871
|
PPM1F
|
CAMK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9442023
10814834
15680915
|
STAT5B
|
STAT5A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15043997
17997837
14532269
|
STAT5A
|
STAT5B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21542777
15043997
17997837
|
BRCA1
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
BRCA1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
ERLEC1
|
SEL1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
902.0
|
0.9
|
STRING
|
36370105
|
SOS1
|
HRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23132018
|
EGFR
|
PLCG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
EGFR
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
GRB2
|
SOS1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23452850
|
AKT1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
PTK2
|
PXN
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
15688067
|
CSK
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
907.0
|
0.9
|
STRING
|
36370105
|
SHC1
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
GRB2
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
16273093
5218056
|
AKT1
|
ARRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
18191226
19122674
19262695
|
EGFR
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
EGFR
|
GRB2
|
â—¼ PHOSPHORYLATION
|
|
|
0.92
|
0.92
|
Signor
|
11726515
|
ESR1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
921.0
|
0.92
|
STRING
|
36370105
|
ERBB2
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MTOR
|
AKT1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.92
|
0.92
|
Signor
|
21592956
|
SHC1
|
USP9X
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.93
|
0.93
|
HIPPIE
|
31980649
19380743
|
NRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.93
|
0.93
|
mint
|
30194290
|
PTK2
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
931.0
|
0.93
|
STRING
|
36370105
|
EGFR
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
EGFR
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
FN1
|
ITGAV
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
AKT1
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
INSR
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
14568990
9593725
11796522
22974441
|
PXN
|
PTK2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
25795725
|
SOS1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
17084389
5219305
|
SRC
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
6672195
16115959
|
SRC
|
PTPN1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.94
|
0.94
|
mint
|
6732073
9600099
|
PTPN1
|
SRC
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
0.94
|
0.94
|
mint
|
6764906
16537444
|
SRC
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
0.94
|
0.94
|
mint
|
11007774
6671922
|
NRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
IGF1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
PTK2
|
PXN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
ERBB2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5218411
16516204
|
YWHAB
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
19595761
8009093
|
ERBB2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
IGF1R
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
SOS1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
24797263
16713569
26005835
9447973
23956138
19531499
7510700
20473329
19289468
25754235
18271526
31959764
10675333
8621459
|
PLCG1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
16713569
7629168
7516467
9020117
21706016
10940929
16038803
9281317
|
SHC1
|
SOS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
8631299
10570290
10025673
8235613
8626525
9544989
10675333
10783152
8950973
7559490
19380743
16371368
9344843
7520523
8621459
|
SOS1
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
16713569
17474147
9020117
10940929
10913276
|
EGFR
|
EGF
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8145580
21439278
|
SHC1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
7518560
8034616
31980649
23956138
9544989
8610109
7542744
25402006
16729043
8665853
15657067
9742218
24797263
10049786
12577067
9756944
23799367
25187647
20935677
10766863
18271526
11408594
7506413
10635327
10595738
24189400
19531499
7542991
20473329
24430869
8662998
9020193
8887653
16273093
25754235
9388490
31959764
26551075
16713569
22973453
24658140
11196191
28065597
20067773
8810340
21278788
30544639
9130710
11370743
|
SRC
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
31980649
8845374
21573184
25402006
7506422
10075741
19704002
10971656
23175185
10777553
22227249
20935677
20624308
21268077
17158602
24189400
9020193
16713569
22973453
11983694
24658140
28065597
21278788
17284441
7797556
20333651
7527393
10358079
|
EGFR
|
EGF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
16274239
25241761
10085134
11684674
28988771
22729867
18271526
30083275
10788520
23597562
19531499
26280537
8663535
25453753
21822280
12297050
2790960
21439278
12093292
12620237
10970856
18427122
25080504
17697999
9135143
15620700
|
EGFR
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
19254954
7518560
31980649
9416834
7592693
23956138
14679214
10085134
7510700
27059931
21706016
25402006
16799092
16729043
8665853
15657067
24797263
12577067
8810325
7650032
11960376
23799367
25187647
8626525
10026169
19289468
18271526
21278786
7506413
17971399
8940013
20124286
11726515
9886492
10595738
24189400
9020117
19531499
20473329
9020193
8662998
8647858
1322798
8887653
10229072
16273093
25754235
31959764
11370743
16713569
21596750
9685397
24658140
31985874
22973453
11896612
20067773
17242169
19836242
8810340
21278788
30544639
7527043
9050991
11408594
8621459
|
SHC1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8940013
6169950
|
SOS1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
5220480
7642581
|
ERBB2
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
9710588
11173924
21278786
16713569
9756944
24189400
31980649
22973453
24658140
30898150
16273093
17875712
16729043
11606575
8665853
|
JAK1
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
11722592
15284024
11294897
8272872
11751884
11350938
12626508
12576423
11940572
10918587
12244095
8626374
9566874
25065853
31462771
14551213
|
SRC
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
10482988
16189514
7499252
9096689
9710204
18840094
8939605
9388490
26551075
|
OS9
|
SEL1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
EGFR
|
TGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
KRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
OS9
|
SYVN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
IGF1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
IGF1
|
IGFBP4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
FN1
|
ITGB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
HRAS
|
RASA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
976.0
|
0.97
|
STRING
|
36370105
|
ARRB1
|
CLTC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
SEL1L
|
SYVN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
SHC1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16729043
5218694
|
GRB2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16729043
5218694
|
HRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
RAF1
|
HRAS
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
PTPN1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
12634852
6671665
|
PTPN1
|
INSR
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.98
|
0.98
|
mint
|
6671880
11506178
|
PTPN1
|
INSR
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
16926280
6671607
|
INSR
|
PTPN1
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
12634852
6671665
|
PTPN1
|
INSR
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
0.98
|
0.98
|
mint
|
17481567
6732036
|
INSR
|
PTPN1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
0.98
|
0.98
|
mint
|
6764581
15588987
|
EGF
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
EGFR
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
INSR
|
PTPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
SHC1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
12485888
21725358
31980649
9126968
7514169
7744881
8235613
11453982
8662733
8491186
7629070
8940013
10570290
8112292
12213123
11302736
8662998
8195171
7597091
8810340
32062451
9129019
16371368
12149229
10049786
8626525
7650032
8950973
9488479
24189400
15812354
12441060
19380743
26551075
22057045
10477741
28690151
16713569
7516467
9733714
11827484
11964172
7537740
16520382
9019162
8663178
9797459
9032244
12577067
9927207
7524086
8995379
9886492
8294403
7559490
9434624
11792427
7798267
8621719
9541596
15688026
12898421
33961781
11370743
25416956
9544989
22974441
8939605
21706016
9083103
7535773
11505033
9175774
24430869
10080542
9020193
9045692
10356320
15888547
9254595
8561895
11707405
8647288
|
HRAS
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
989.0
|
0.99
|
STRING
|
36370105
|
EGFR
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
RPN1
|
RPN2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
DDOST
|
RPN2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
DDOST
|
RPN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
EGFR
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
GRB2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
PCNA
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
E2F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
BRCA1
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
E2F1
|
â—¼ SHARES_COMPLEX
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
E2F1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
ID4
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
11136250
12032322
16582598
17016441
21194482
24475217
|
E2F1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10660629
23285190
18660752
19466541
17106239
20068145
23108140
|
TP53
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
24.0
|
1.0
|
Omnipath
|
9582019
11295099
18625847
11003642
12802282
16357511
14710355
9619832
19882681
10884389
11384963
11782367
12024039
15735697
12170778
21245169
17993233
12549011
11431698
16229810
18208621
10597265
21742769
|
E2F1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9244350
18660752
18319725
11278247
12697828
16713569
12909625
|
AKT1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
17428466
20832017
20085797
21242970
17570479
10542266
|
BRCA1
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12887909
12485996
11239454
25652403
14499622
16713569
|
BRCA1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
11244506
12400015
15674350
10334989
16713569
11493692
|
SRC
|
CLTC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10089883
19289168
12237126
|
TP53
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
21715977
20805247
8557038
11795482
17210690
22952705
|
ESR1
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22791811
20215421
12697671
10446910
|
E2F1
|
PCNA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
7623816
12782299
14618416
20580656
9389735
11133765
8903355
9649317
23078099
12468739
1261188
|
E2F1
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22241525
8557038
15706352
21441950
12675512
23954287
12625370
|
E2F1
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15510213
18319725
11491305
|
E2F1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
22480684
11739724
12625370
|
EGF
|
EGFR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
ACSN
|
15003992
15175028
15466195
15958574
18423981
19631971
20430953
21098712
8101258
|
EGFR
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
10404636
20430953
23010081
25987127
28513565
|
EGFR
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
10404636
20430953
23010081
25987127
28513565
|
CAV1
|
EGFR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
11102446
17517963
18458534
19411448
20855962
21051947
21150282
21729786
22411312
22874531
23907124
25364523
26828520
|
WT1
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
19014381
8827073
19321755
20944147
11071895
9291179
7588596
|
TP53
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
20190820
18359760
9664135
10029407
8152794
11713584
8887630
9285564
19597475
11546792
1586628
18604200
18391986
|
ESR1
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12894229
12421825
8200909
21705183
|
SRC
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
232.0
|
1.0
|
Omnipath
|
16414009
17081983
25958313
16943190
15618223
19935697
19305428
25402006
24797263
29285309
7488034
15592458
17389395
16461772
20562096
19275932
17897439
15899872
17570479
2803273
23636329
23246962
25505586
23175185
15615697
23349873
16849545
25356505
11983694
24189400
11756413
25748412
26325669
26150526
14512423
18789131
14750954
31978707
25573954
27495374
20071362
18707149
28759036
16729043
26494466
27716204
25537504
17237269
18687633
25884760
29036202
26936397
17575160
20926745
20935677
15282306
23702846
15476828
9069259
19336574
20421302
15660394
23866081
19377510
9777370
22426783
29321659
33706413
25841779
19840943
18669648
12397069
16843263
18957516
34088769
25077442
14963038
19836242
17653080
19625610
16936701
11960379
15548697
18295415
17523611
21268077
20333651
21399647
23376850
11250711
23942551
19704002
22927910
11160627
31952541
10777553
17016520
2543678
19258037
33883672
17646646
28102297
23873690
26771606
21573184
23119029
19151764
16713569
7797556
25955608
15302935
20407013
28513565
23119185
9990038
21080693
20190765
25347738
14630916
15708852
21822308
20628053
25301722
24658140
19690143
27564112
20802523
29124875
33657368
12101233
21787862
14764607
17284441
12878163
26290602
15951569
16543144
15212693
17971399
14523024
10971656
21278788
8845374
22430206
18083107
29641465
18234969
18460189
17551925
22957061
26571308
17043637
20371672
10358079
16799092
19154417
23066441
28065597
12842895
18180459
17158602
18271526
15657067
25159151
34367939
24919575
10075741
25366117
24349301
17561374
16862179
20215522
31980649
24335899
16037379
18451158
14530278
16505275
12063263
23449029
11311660
|
MAPK1
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
12556561
1651322
17081983
3138233
15901825
1939237
91332050
2543683
2115882
17192257
1651323
15302935
|
MAPK3
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
1651322
17081983
3138233
15901825
16785992
1939237
91332050
27531070
17570479
2543683
2115882
34086370
17192257
1651323
15302935
|
TGFA
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
17145710
21722395
28988771
25402006
23155381
3018723
23331499
16585207
10209155
24658140
10775655
31980649
12297049
8663070
12648464
27635238
|
EGF
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
131.0
|
1.0
|
Omnipath
|
17145710
17081983
21822280
20813200
23613900
9135143
25453753
21303971
10209155
26821125
12297050
27387652
25241761
30083275
12093292
30197274
21649524
19531499
18762250
16729043
26921391
17697999
17575160
21722395
12620237
19129184
10788520
23331499
3494473
15620700
14568001
15958209
24096486
18253097
16843263
18320059
21532939
10085134
22260327
15708576
26280537
23912460
21858221
11116185
10970856
27462018
18427122
25080504
20953304
19135477
11684674
8639530
27564112
18270696
2790960
17971399
23185569
19895983
28988771
29617357
23597562
19531623
23950932
21071413
8663535
6289330
16274239
17563729
21439278
20458382
22216880
18271526
12771140
21311755
24709886
25366117
12648462
21107857
|
PTPN6
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
9038217
9287352
7673163
7518460
9733788
|
EGFR
|
PTPN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
25796184
31980649
8621392
12573287
18253097
11106648
11506178
24658140
7540771
9050838
9355745
15982634
25402006
10889023
7693694
8999839
|
EGFR
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
89.0
|
1.0
|
Omnipath
|
19901323
17081983
16273093
9207933
2472219
16497976
15592455
16126727
16713569
24797263
17389395
8578591
23331499
7991458
1689310
20068231
17570479
9176240
12803489
16153436
7993895
16038803
7805859
15864276
1708307
7682059
15144186
11983899
12601080
9756944
15212693
14568990
12061819
9020117
8885868
12648464
8657103
15951569
17016520
7693694
|
EGFR
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
23331499
31980649
10358079
24658140
25402006
18586824
16729043
|
EGFR
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
109.0
|
1.0
|
Omnipath
|
9544989
10595738
23956138
27059931
10026169
16273093
11726515
24697349
21596750
19289468
7518560
21706016
23799367
9050991
16317285
16713569
25402006
11370743
24797263
8647858
8887653
9416834
21278786
16799092
8662998
10229072
11896612
7592693
19509291
8810325
24189400
19836242
11960376
7506413
18271526
15657067
10085134
24658140
17242169
7510700
8940013
7650032
8810340
11084343
12577067
7527043
31980649
11408594
19531499
20124286
23178716
9886492
23181695
9020117
8479540
14679214
12648464
1322798
17991782
16729043
17971399
|
EGFR
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
17496910
31980649
23956138
19531499
16273093
24658140
11172806
1334406
25402006
|
EGFR
|
STAT5B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
10830280
10358079
12411494
10558875
16729043
17016520
11751923
|
EGFR
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
20809984
17284441
16713569
11887937
|
EGFR
|
PLCG2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
31980649
25241761
16273093
24658140
17570479
25402006
|
EGFR
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
65.0
|
1.0
|
Omnipath
|
17081983
16207817
21044682
17148612
24557338
16713569
21203579
10233167
20471394
17389395
17486068
21278786
11500516
11279155
11500850
17426253
16843263
19650109
25241761
24189400
15657067
17307140
18803307
1706616
12354693
10572067
24355130
11408594
19060928
12648464
16516204
15951569
23436906
20211985
|
EGFR
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
78.0
|
1.0
|
Omnipath
|
9544989
8808684
10595738
23956138
9388490
11350724
16273093
7542991
7681824
7518560
9710588
23799367
16713569
25402006
11370743
24797263
9742218
20935677
8887653
8034616
23331499
8662998
7542744
10049786
28065597
9130710
10635327
24189400
7506413
18271526
15657067
24658140
8810340
12577067
11196191
10766863
23178716
31980649
35384245
11408594
19531499
9756944
26551075
1623525
15951569
16729043
17956904
|
EGFR
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9544989
19531499
9447973
16713569
12577067
|
EGFR
|
SHC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
11350724
16273093
8760305
|
EGFR
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
8647858
16273093
7991458
1850098
17570479
1633149
1385407
|
EGFR
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
16713569
16919435
25402006
10806474
29435030
20473329
7657702
19339212
17496910
15657067
24658140
19625610
7529872
20802513
31980649
10545505
24043698
15951569
|
EGFR
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
38.0
|
1.0
|
Omnipath
|
17145710
23956138
12070153
20145033
14967450
20032199
21573184
25402006
10358079
23894143
14966128
24135280
25241761
14963038
24189400
15657067
24658140
15485908
15950906
18258752
31980649
9756944
22693070
12873986
15951569
15284024
|
EGFR
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
23956138
23178489
18237807
18789131
|
EGFR
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
21220489
24655521
23542172
29140271
28157503
26725162
22238610
25825764
17115032
26719139
28102297
22692198
28666590
25073158
20670598
20587074
23593472
25675097
|
EGFR
|
CAV1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
17145710
31980649
22411794
9374534
19446582
16799092
12388423
15657067
24658140
19625610
16407214
18789131
25402006
15951569
10781609
16332692
|
PCNA
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCI
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21719678
22855611
24451376
17460694
27773793
20603015
25168188
19561358
18931676
24623813
|
PCNA
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FGF19
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11353842
9632781
14534538
9182757
|
STAT5A
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
16627759
22411868
11090077
26515730
20111072
15498859
10698507
12468433
12796379
30552988
23103841
31066629
15003515
17356133
|
STAT5B
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
16627759
22411868
11090077
26515730
20111072
15498859
10698507
12468433
12796379
30552988
23103841
31066629
15003515
17356133
|
GRB2
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11353842
9632781
14534538
9182757
|
GRB2
|
VEGFB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
GRB2
|
VEGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
GRB2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
GRB2
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
GRB2
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
SOS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
28514442
16520382
31980649
32062451
8493579
21988832
14679214
7510700
7514169
21706016
10319320
32203420
9872323
9797459
34407391
16906159
10716926
12577067
8810325
7629168
11960376
7664271
8626525
15192046
7629138
11997436
8943292
10207103
8695800
10570290
10025673
8112292
11726515
8816480
20473329
7559490
7773779
9447984
19380743
7642581
7527391
9716598
9344843
10477741
16713569
19323566
7516467
17474147
9569023
8188688
16893902
11964172
9478994
33961781
8479541
28166272
9009162
|
GRB2
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
GRB2
|
PLCG1
|
â—¼ SHARES_COMPLEX
|
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
GRB2
|
VEGFA
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
GRB2
|
VEGFB
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
GRB2
|
RAF1
|
â—¼ SHARES_COMPLEX
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
HRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
NRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
GRB2
|
PLCG2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10072481
10086337
10567412
10781611
10811803
10982827
11169415
11447289
11777939
12175651
12640133
14764585
15567848
15574420
16102570
16329184
16582911
16887996
17496910
17673906
19449109
19494291
19909365
23620508
25137453
26552706
7523143
7890616
8551221
8649391
8976179
9489702
9535722
|
GRB2
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
GRB2
|
VEGFA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
GRB2
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
GRB2
|
ITGB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
26.0
|
1.0
|
ACSN
|
10086337
10426994
10567412
10811803
10982827
11447289
11777939
11777960
11907067
12175651
12640133
15536084
15567848
15574420
16339513
16582911
16713974
16887996
17070508
17100878
17496910
17673906
18490724
19449109
26552706
8551221
|
GRB2
|
VEGFB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
ERBB2
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
31980649
9756944
21278786
16273093
24189400
11173924
9710588
24658140
11606575
14967450
17875712
16713569
16729043
|
SHC1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
198.0
|
1.0
|
Omnipath
|
8808684
9083103
8551221
9126968
8621483
25416956
9252386
8524223
7535773
8662998
11302736
11827484
8995379
9541596
9175774
10207047
7717978
17673906
7744881
11505033
10523831
24189400
9927207
7650032
8810340
9045692
23178716
19531499
15812354
9129019
10356320
12485888
9461587
8114695
7514169
9566877
8939605
16371368
15341520
7529871
10891441
10749687
7524086
26645482
8491186
10592173
10049786
9171350
11707404
7537740
15688026
8663178
19380743
11782427
9544989
16436051
9434624
16713569
21725358
11964172
17314098
11792427
8195171
1465135
12213123
8647288
12955078
10477741
11707405
12577067
9199344
10080542
8112292
7760801
10570290
11997181
7798267
16520382
10961885
8950973
21706016
9448048
8662733
11370743
8051109
9733714
8621475
9254595
8294403
10748054
8621719
8940013
12441060
22057045
7505797
24737791
20697350
9886492
18174162
18273058
8235613
7963520
7523859
|
MET
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9660480
15546961
22128289
12475979
11063574
7511210
11439336
8662889
|
EGF
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17081983
19531499
17673906
10973965
|
SRC
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12624098
11964172
9016807
16713569
26103942
20554525
|
GRB2
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
10806474
12558988
8649427
8816475
11119718
16298995
7597091
7997267
9148935
12110680
12005431
10085298
16713569
10749687
10354709
21900206
|
GRB2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
145.0
|
1.0
|
Omnipath
|
9544989
9872323
7642581
15746962
11726515
8621483
23334917
16520382
11997436
21706016
10359574
8950973
7664271
16713569
16893902
16906159
21988832
19323566
9009162
10716926
11964172
7629168
9815779
10592173
9716598
8647802
28166272
7773778
7773779
18778683
8188688
10319320
8810325
9344843
23452850
11960376
8816480
10025673
7510700
8940013
12955078
9697839
12345678
10477741
8493579
8943292
12577067
7862167
9199344
8112292
7898932
10207103
8695800
19531499
10570290
7760801
20005866
19380743
9447984
8235613
8479540
7527391
14679214
8479541
17474147
7514169
7629138
|
GRB2
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9281317
15953601
7629168
9020117
16713569
10940929
|
GRB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17496910
16713569
17673906
11352655
|
NRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
HRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
FGF19
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK1
|
FGF23
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
PTPN7
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
10206983
10702794
25241761
10415025
12592337
16226275
|
SHC1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10996427
23584453
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
9804779
25241761
18775330
10194762
8226933
10996427
9604935
8388392
12091337
|
MAPK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
17081983
18767875
15849194
19690332
11409918
14654779
23331499
23180781
8226933
20068231
18988627
21917714
18669648
19541618
18691976
16407412
19933846
9922370
15664191
8388392
19651622
10801873
8349614
18775330
9604935
|
MAPK1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
59.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
15465816
25584415
12576423
11350938
20068231
12681450
12763138
9872331
11780390
18491316
18669648
11404481
10521505
18691976
20058876
15979846
14551213
10446219
|
MAPK1
|
NFATC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15657420
|
MAPK1
|
PXN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10753946
15494312
11784715
14636584
|
MAPK1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
23331499
10197981
8816480
9922370
8626428
|
MAPK1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
15655247
10949034
15528270
18372406
15461668
12118371
12466266
7495695
17615152
15059947
16076840
7491495
12093745
10409727
9528769
7838153
|
MAPK1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
14965474
9765199
15116093
21675959
23443559
10781582
25241761
10446957
10958792
11409876
11709713
21147777
10673501
11551930
15867353
11875057
12091386
|
MAPK1
|
ARRB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
19651622
19153083
18767875
17322306
15456867
10347142
20068231
19413330
9388255
|
KRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
FGF19
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK3
|
FGF23
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK3
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
9804779
20508164
23331499
24263804
18775330
10194762
12407017
8226933
17502367
34188118
9604935
18988627
31932645
8388392
12091337
|
MAPK3
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
73.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
23331499
15465816
25584415
12576423
11350938
20068231
12681450
10417333
12763138
9872331
18988627
11780390
18491316
18669648
11404481
10521505
18691976
19723038
20058876
14551213
10446219
|
MAPK3
|
NFATC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15657420
|
MAPK3
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
10781582
11239457
10958792
28937686
9467949
10348343
24194938
9739174
16713569
12955074
10747897
17237827
25767119
18523266
12393879
|
MAPK3
|
PTPN7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
10559944
10206983
10415025
18088087
16226275
|
MAPK3
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
10949034
18372406
15461668
9528769
12118371
14680484
17615152
15059947
16076840
7491495
12093745
15212693
15528270
7838153
|
MAPK3
|
NFATC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
10652349
|
MAPK3
|
ARRB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
19651622
19153083
18767875
17322306
15456867
10347142
20068231
19413330
9388255
|
MAPK3
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
29145629
7478566
23331499
8816480
7739560
17570479
9922370
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
MTOR
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
MTOR
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
29228628
10660304
22408571
12796477
16740698
18691976
26573296
15522880
27384580
26775702
24423131
26241748
23055980
|
MTOR
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
80.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
24670654
16697215
11438723
21592956
20398329
17461779
18372248
21177249
21045808
20338997
15808505
16221682
20138985
20489726
15899889
20214616
8978681
21474067
14970221
19203586
17660512
15718470
19568798
20333297
23006971
15169778
25241761
18566586
19720745
17517883
18925875
22084251
10949026
14761976
11715018
19143635
17277771
18636226
10910062
15047712
9812896
18505677
21343617
19844585
17680028
19151919
18566587
9736715
23872070
10722653
20832730
18570873
17013611
17052453
12408816
15364915
11274345
|
PRKDC
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
15355354
19398950
15254178
9372954
11483158
7862459
16713569
11875057
11551930
11883897
12548019
25168287
8502477
11709713
10446957
28145533
22726545
24886358
16552184
12242661
17570479
10196661
10747897
9885574
10673501
12091386
22355272
9765199
15489221
9561848
10801407
22504299
22444248
15177184
11042698
10358069
10470151
10606744
9744860
16397295
12959929
12064478
27130668
10951572
12111733
25937999
15381073
28102346
9363941
19918261
|
PRKDC
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
318.0
|
1.0
|
Omnipath
|
27120806
14555685
20028775
20176926
11287317
27542271
26740621
11731414
12393602
34197700
17993646
21940452
21946537
11278872
22975685
16908595
18316359
34073781
24735537
18039660
24652283
20856200
26170313
21300025
15388791
19144640
26297026
17545609
33941854
16280327
10625301
33845796
25918246
34385295
17537996
14645219
20804212
15084259
12169689
21795477
22071574
23913047
34021259
21695150
15684384
33958720
14530366
16670089
19487463
19223464
17303569
25481872
15475446
17116771
28967905
33753495
12438236
29562639
16753042
33836561
19073147
15169778
16891474
19477925
16338973
16397245
34562454
15821749
33767437
34087103
11409731
18381446
15737995
27481935
11313365
26700621
17210635
25447541
33931486
17827393
17126298
15262962
28542588
33574930
11821945
20471940
15461589
17077177
33579227
26921343
17386266
33744230
26848618
12944390
33566837
26902421
21042280
21763421
34380642
18321849
14593122
25775124
25739674
17229808
26351843
24102046
23757022
33532186
16043647
24632620
12781924
25738875
10864894
17974989
25719244
15806160
16497987
25851605
20501647
18439899
28209968
10973320
24819169
25745998
34383763
19592491
19244117
19204084
29088759
26871475
34257082
26755732
17237292
17709744
17640984
34405859
18480058
33995548
22310280
20211239
12052823
22580611
31937616
19920202
26745759
15905173
12499277
15028555
27162341
21106850
33562475
30065170
23462102
15678105
15642728
27065332
28558072
28977846
15319269
21339742
15855334
21045808
20145118
21297104
18632646
17379600
15471950
23474758
26887938
11375271
20013032
18701889
16540596
15314172
28515473
15964826
19638206
25892239
28692056
20530876
27505672
25100728
21242970
17297446
10542266
14670178
15548374
33741342
12429574
11002428
15831486
17116756
25435370
32833881
11402048
25361894
15207915
20729916
15625077
18677106
12869565
11250155
21356307
15967841
31936857
25943101
18394555
12644590
14500543
18691549
27197158
15623569
33477794
12062056
16754797
15383526
21909137
21949775
20085797
16807298
15899889
33868961
23940660
23434580
33927349
23899556
14990993
12000752
27880719
26065416
19060924
34520759
14679308
15334055
17283158
25257795
17548608
30586628
24437487
20124472
15289327
23325788
21208159
33664452
31679687
12791703
15047712
17166829
26146988
17329400
20660158
21532621
21806543
20179209
25661488
20957047
17562705
19915805
12606948
17277771
10377409
25893295
17270736
16407838
20597130
15047168
28658616
16357520
15537647
12818176
11425855
17210830
19800394
12506011
21310961
16963136
21996732
15695828
33835469
11701613
19010331
26686089
28915558
15467762
17586693
18456663
34381564
18765673
20233713
34208786
11029403
22084251
20622007
12077256
11313948
16917505
19448664
27391337
15792956
21172654
15608670
12438239
19875458
22014578
25071014
11809760
18728186
31391321
33891611
19805619
33407730
25868858
25320242
34348155
20832730
|
STAT3
|
STAT5B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23073628
15790786
11369651
15007386
12481435
15526160
28403213
10358045
28192400
17546049
9355737
|
STAT3
|
STAT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23073628
15790786
11369651
15007386
12481435
15526160
28403213
10358045
28192400
17546049
9355737
|
JAK1
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10426994
11907067
12244150
12811837
15536084
16081783
16713974
16785506
19833085
20856220
21840487
23124025
24751819
7512720
7521688
|
PTPN6
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
13.0
|
1.0
|
ACSN
|
12176909
12773515
12917349
15240681
15713798
22513334
22952938
25355530
26667266
27474009
8976179
8986721
9765283
|
STAT3
|
CXCR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
STAT3
|
SOCS3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
STAT3
|
VEGFA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
STAT3
|
FGF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
STAT3
|
A2M
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
17487688
11319221
7509445
11438543
16959875
7592638
9266835
7876144
11466367
8964411
9722518
7519723
|
STAT3
|
VEGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
49.0
|
1.0
|
Omnipath
|
22076197
19880237
12824281
20232316
18320073
20482858
17557905
21354136
19020709
17937859
20880395
25101566
16007214
19284568
19336759
20236940
10744750
11960372
15688401
19082717
21344490
20939432
17533737
21733558
18021292
20720018
11744720
23104276
16540670
11960378
20043094
21278793
21418908
15665043
15735682
21172343
23756865
20052595
17169602
18184402
21731766
23911788
12545153
22313388
16899623
20709526
18408167
|
STAT3
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
18489773
22179221
15184887
21994466
20032196
12565872
11682619
23782265
22943202
19628067
23335796
12639901
18571793
23104276
16293640
23027374
22739025
21098664
11788008
18237746
19535626
23303450
20357037
16783372
22575502
16709613
14688368
19332118
23439558
10359822
19910459
19759305
11159537
16300827
16718380
|
STAT3
|
HGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
14647442
18835816
16407846
11278729
23954444
17967179
12168776
|
JAK1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
121.0
|
1.0
|
Omnipath
|
18691551
20169197
19901323
12626585
12759422
15805299
10918587
9305919
15261459
21420464
8272872
10851062
12093291
17878297
12626508
12351624
12040185
16497976
15592455
20966397
8662928
18941194
17389395
23331499
11306517
8756628
12576423
11350938
12244150
18669613
7796300
11294897
24710148
11163236
11722592
11418623
8085155
12244095
21690253
14764663
9535918
21098725
9083098
8662591
22905257
14565860
27774606
8626374
19723038
29145629
26260587
9566874
24501689
25297818
9651359
11940572
11429593
11564763
12517932
14551213
8662795
19535621
23124025
18389480
15284024
11706020
11850821
17016520
9582023
17595657
|
SRC
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
88.0
|
1.0
|
Omnipath
|
19901323
10918587
9305919
8272872
29036202
9344858
12626508
10815799
16497976
15592455
16713569
17389395
12576423
11350938
9484840
11294897
28978186
18070987
12244095
27472461
21690253
23928694
22303479
8657134
11404481
9083098
14963038
8626374
17016520
9566874
10982829
15212693
11940572
11429593
14551213
15037656
15313931
11850821
9154828
9582023
|
PTPN1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
15821101
23331499
11970898
|
STAT3
|
VEGFA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17987801
16716598
13130303
7768934
11528470
9278421
|
ESR1
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
20080630
16115928
22787161
12750288
20696891
17681750
17699779
|
TP53
|
PTK2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
24809783
20515733
21355845
21071137
21269258
18493017
17999388
17725966
|
TP53
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
15131018
11001824
12089352
20633551
24205274
17097318
10023442
17600529
17014845
8710868
12444079
16181796
22033326
|
TP53
|
SCO2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
27692180
20729871
16843260
|
TP53
|
VEGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
8108142
20639906
9377555
21325822
16684540
9833779
10910082
16835303
23449391
8521408
15860260
11971180
11559575
|
TP53
|
KRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11514734
18555006
10953306
14741382
19107228
20124454
8274455
16061648
10448271
|
TP53
|
PCNA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
10321841
7915517
15358233
12217864
10516009
1705714
8570655
16980608
9707425
15950182
19789303
11313928
1356162
12384701
9858527
12947108
23390122
8524244
9651310
1352831
7909518
11032828
10910968
12485898
10618724
|
TP53
|
CAV1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10684646
20610713
17014845
11076533
|
TP53
|
HRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21552926
9662334
11127813
21552928
|
TP53
|
IGF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12631625
18281476
18174288
21460853
|
TP53
|
IGFBP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10101800
23810988
15661074
7566179
15713654
18084616
9525742
20003326
|
TP53
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12485897
18661553
19763735
|
DUSP26
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
27764791
20562916
23996700
|
WT1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
16713569
10744705
8389468
|
TP53
|
IGFBP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
7566179
17409411
18431400
|
TP53
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
18431400
25241761
15855171
18206965
19857493
|
SRC
|
VAV3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17686471
8986718
11007481
10395673
9099726
|
PLCG1
|
VAV3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11094073
10592173
|
SRC
|
VAV3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17998938
11917103
|
AKT1
|
APPL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
25241761
10490823
25814554
12621049
|
STAT5A
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17609438
10359822
19115200
12468433
21397011
12198248
11713228
15778369
|
JAK1
|
SOCS3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
25682267
10950967
16459330
10707961
10373548
|
SOCS3
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
11071852
25138272
25888955
21873554
12560330
25352752
11325969
|
SOCS3
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
11331873
|
VEGFA
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFA
|
VEGFB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
58.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
16000375
16002046
16076871
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19414323
19449109
19454690
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFA
|
VEGFB
|
â—¼ PROTEIN_INTERACTION
|
|
|
58.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
16000375
16002046
16076871
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19414323
19449109
19454690
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFA
|
SHC1
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFA
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFA
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
ESR1
|
VEGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
16267616
12400015
17272396
18252963
18497067
10866309
19420388
19398483
16249470
14647449
15774498
12208749
10995484
|
PGF
|
VEGFA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12796773
25241761
12086892
8621715
|
SHC1
|
VEGFB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
SHC1
|
VEGFB
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
SHC1
|
VEGFB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
VEGFB
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
ITGAV
|
ITGB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
23.0
|
1.0
|
ACSN
|
10022831
10545505
10837075
11146654
11335727
11532940
11553709
12000961
14697347
15031725
16919435
18353785
19161977
19339212
19449109
22035837
7512751
7529872
7657702
8636223
8755653
9295024
9763615
|
ITGAV
|
ITGB3
|
â—¼ SHARES_COMPLEX
|
|
|
23.0
|
1.0
|
ACSN
|
10022831
10545505
10837075
11146654
11335727
11532940
11553709
12000961
14697347
15031725
16919435
18353785
19161977
19339212
19449109
22035837
7512751
7529872
7657702
8636223
8755653
9295024
9763615
|
FN1
|
ITGAV
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
1694173
18480047
1532572
19738201
23154389
17015452
|
ITGAV
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
19889638
12844492
23397142
10545505
7657702
8636223
10022831
19339212
11927607
19161977
16919435
7529872
11553709
8755653
7512751
|
FGF19
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9045692
9480847
18840094
7559490
|
FN1
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
19342448
21844907
10714768
8598224
|
SHC1
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9045692
9480847
18840094
7559490
|
IGF1R
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
10086337
10826997
12175651
12444011
12767520
16931767
17145802
19030972
21540285
24103846
24782617
|
SHC1
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
ERBB2
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
28065597
23331499
9756944
16273093
8026468
9710588
10085134
24658140
9590694
16713569
16729043
16843263
|
PTK2
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11980671
10592173
16713569
10725339
10749687
9566877
|
IGF1R
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
12767520
15629149
7541045
17145710
8776723
7559507
14764897
17570479
16113100
24051437
17673906
|
MET
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
9083103
11687594
9660480
14990987
24728074
8084588
8939605
8947042
7731718
11884620
15688026
14685170
|
SRC
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
19901323
9388490
8939605
9096689
10971656
16497976
15592455
9121430
10891441
17389395
11687594
10329689
10482988
20068231
17570479
16189514
9685404
23109003
7516469
9927207
18840094
15688026
15212693
1409579
14963047
9710204
26551075
17016520
11075717
|
INSR
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
93.0
|
1.0
|
Omnipath
|
9083103
17145710
19901323
10803466
20230923
16497976
9121430
15592455
9446569
17389395
18578522
7559507
7537849
10482988
10764799
10921922
18452278
20068231
10592173
7499194
18669648
15629149
12522270
9685404
10896916
9927207
9593725
12237775
8702728
8610109
19651622
15212693
9741627
9710204
19664994
7685165
8626723
17016520
10816433
11075717
|
CSK
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
12767520
12048194
18829532
9819392
19380743
10037694
17673906
|
PTPN12
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
20697350
8939605
12052829
24189400
24412244
7929214
20075861
19380743
11342545
8626541
11432829
|
SHC1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
9544989
8631299
8621483
8950973
10891441
10783152
9278309
17673906
9344843
8294403
8021500
10025673
7520523
12955078
12577067
9199344
19531499
7760801
10570290
19380743
8235613
10675333
8114695
|
HGF
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9038378
7513258
9070211
8703035
7708691
|
HGF
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11290563
12649206
15059978
16212809
17145802
18633355
19631971
20303741
22763439
23402812
23667593
26366398
26819959
27474009
28475121
9242465
|
HGF
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11290563
12649206
15059978
16212809
17145802
18633355
19631971
20303741
22763439
23402812
23667593
26366398
26819959
27474009
28475121
9242465
|
FGF2
|
HGF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11874475
18232728
18633355
18776941
19508171
19631971
21098712
22652804
23123598
25374926
9242465
|
FGF1
|
HGF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
14517404
16272825
16682805
26183471
9242465
|
HGF
|
FN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
8780385
25241761
15717924
|
HGF
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
57.0
|
1.0
|
Omnipath
|
17145710
22897854
15167892
1655405
20624990
19433454
23331499
17804794
1846706
28475121
22001117
16537482
15218027
27147579
24362531
17667909
16397249
20178463
17981115
28534512
8380735
18495663
14685170
|
PDGFB
|
PDGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9334164
10508235
1311092
8900172
|
PDGFB
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
7685273
9488729
10508235
9739761
|
ITGB1
|
FN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
12731048
18037882
19161977
19454690
19487819
20644254
20814939
22067905
22470492
24202395
9003039
9456329
9763606
9973479
|
ITGB1
|
FN1
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
12731048
18037882
19161977
19454690
19487819
20644254
20814939
22067905
22470492
24202395
9003039
9456329
9763606
9973479
|
ITGB1
|
PTK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
12731048
18037882
19161977
19454690
19487819
20644254
20814939
22067905
22470492
24202395
9003039
9456329
9763606
9973479
|
ITGB1
|
FN1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
12731048
18037882
19161977
19454690
19487819
20644254
20814939
22067905
22470492
24202395
9003039
9456329
9763606
9973479
|
FN1
|
ITGB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
9842903
22451694
17015452
18480047
19738201
7688313
1694173
6325925
25237190
26456826
10772816
7626807
21985969
6284125
1532572
11010812
8120056
|
ITGB1
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8649427
21909923
8878413
10545505
7657702
9003039
19339212
19487819
19161977
16189514
16919435
7529872
19889638
|
IGF1R
|
CSK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
10026153
|
CSK
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
55.0
|
1.0
|
Omnipath
|
11489946
23051580
20657842
20337577
7592628
23824743
21940449
26453921
22323292
14665621
17525734
14967142
3103926
23159740
16227616
1383688
12387813
20525307
10698938
7525268
19534553
16537894
26234813
10592173
12468645
7513429
24632723
7687537
21442427
22689825
25372749
11007774
9208935
18614016
28974561
21632985
19369195
17855352
7678701
23378895
9523754
|
CSK
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
18823558
21829547
9890993
27803182
21062671
7529872
21709741
|
CSK
|
PXN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
17389395
18707149
27447856
11695992
7529872
9890993
14665621
|
PLCG1
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
36.0
|
1.0
|
ACSN
|
10072481
10781611
10811803
10925299
11169415
11476890
11532940
11994416
12040186
1281218
12845332
14585353
14764585
15214048
16488589
16919435
1712101
17397400
17496910
17517963
19568798
19909365
23523669
24584707
2536067
25456276
25572304
25960930
26552706
27216177
7682895
7890616
8226994
8649391
9535722
9846483
|
PLCG1
|
SRC
|
â—¼ SHARES_COMPLEX
|
|
|
36.0
|
1.0
|
ACSN
|
10072481
10781611
10811803
10925299
11169415
11476890
11532940
11994416
12040186
1281218
12845332
14585353
14764585
15214048
16488589
16919435
1712101
17397400
17496910
17517963
19568798
19909365
23523669
24584707
2536067
25456276
25572304
25960930
26552706
27216177
7682895
7890616
8226994
8649391
9535722
9846483
|
ERBB2
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
16273093
1676673
1683701
|
SRC
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
8388373
16497976
16126727
16713569
17389395
1689310
20068231
17570479
16153436
16038803
1708307
7682059
7510703
18594017
12601080
8885868
8657103
17016520
|
PTK2
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
8660853
26278977
10430888
23397142
|
PLCG1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
15953601
12084069
7629168
9020117
16713569
10913276
17474147
10940929
|
PTPN12
|
PXN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
9497381
19167335
10625692
11950600
10085298
10400685
|
PTK2
|
PXN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
109.0
|
1.0
|
Omnipath
|
16298995
26053221
15688067
15572663
15592455
7963537
17389395
25405379
26546726
9658172
15107421
22581436
10823820
16254239
25226367
15817476
10330411
9756887
19543320
9054445
10545505
18707149
29127427
15494312
10764815
7537852
9442086
33823745
12408869
20419088
20655620
22270917
18669648
28373581
10455189
16094384
23936270
19138410
22638989
11337490
11514617
27402964
16713569
7615549
10931187
11774284
26700725
27708220
20068231
20473365
28928239
7561682
34475475
28427224
28068967
8922390
24885567
23209645
27669437
15212693
26711338
9422762
11304546
28214467
26697169
12065577
28415719
10753828
11919182
24364863
9230116
11113628
21741599
10417825
15252114
24642576
22044652
21034468
|
SRC
|
PXN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9636140
28214467
15572663
15592455
16713569
14665621
25795725
7537852
7615549
25405379
11774284
26700725
25182764
15107421
7534286
2472406
12408869
11695992
17570479
10823820
7525621
20103658
16254239
15817476
23109003
27447856
28626446
16094384
18363833
19543320
24364863
28376152
19138410
25323586
27941878
23457577
10085298
22638989
27669437
15212693
|
INSR
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
8692915
14699166
12468540
7512963
17570479
16497976
18377662
14757045
8114715
|
SRC
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
8692915
17675340
14551136
25535246
14699166
12468540
10574931
16649996
8647855
7512963
9261115
34010642
14757045
12468645
8114715
15212693
10488096
21900501
|
PTPN6
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
23331499
9520455
23180781
9852037
14624462
8524272
7629131
|
PTPN6
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
21780115
15032589
11526404
23109003
9065461
22880054
10488096
|
PTPN6
|
SIRPA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
8943344
10660620
17954568
18233962
16920950
9632768
16189514
10660565
14662855
|
JAK1
|
PLAU
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11306493
18633355
19833085
21840487
22470492
22595692
27216177
7512720
7521688
|
JAK1
|
PLAU
|
â—¼ SHARES_COMPLEX
|
|
|
9.0
|
1.0
|
ACSN
|
11306493
18633355
19833085
21840487
22470492
22595692
27216177
7512720
7521688
|
JAK1
|
PTK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
ACSN
|
11306493
18633355
19833085
21840487
22470492
22595692
27216177
7512720
7521688
|
JAK1
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9047382
16741510
11722592
10781830
|
JAK1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9774657
15021914
|
JAK1
|
STAT5B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16741510
10781830
9047382
|
EGF
|
PLAU
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
12094222
15003992
15175028
15466195
15958574
18423981
19631971
20430953
21098712
8101258
|
FGF2
|
PLAU
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11874475
18232728
18633355
18776941
19508171
19631971
21098712
22652804
23123598
25374926
9242465
|
PLAU
|
PTK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
ACSN
|
11306493
18633355
19833085
21840487
22470492
22595692
27216177
7512720
7521688
|
HRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
RAF1
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
YWHAB
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
KRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
10958680
12750173
9516156
12932319
9665134
10783161
8805624
1386920
1639773
8340422
8601312
19595761
23331499
16041367
21071413
8332195
9446616
10882715
25852190
10531446
1996324
19029954
8503013
16093354
19541618
23153539
16293107
1708096
19933846
26721396
11136732
10205168
20802526
31980649
7760835
18775988
8307946
12917261
11134016
20080631
8180183
1990291
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
HRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
147.0
|
1.0
|
Omnipath
|
17145710
18273062
9523700
1639773
8601312
19595761
20133694
11032808
9154803
10882715
14654780
1996324
19222999
16301319
11948414
8530446
7969158
11313862
9150145
20080631
1990291
12750173
15031288
12932319
9665134
8805624
8340422
1386920
23331499
16916524
16041367
23180781
18988627
20178605
15688026
15664191
22169110
11733498
7862125
8180183
19063885
12391160
9144171
8035810
9020159
14724584
19696784
21779497
9261098
12173045
12620389
8628317
19914712
1708096
19933846
26721396
7730360
10205168
8332187
16803888
18775988
12917261
9099670
10545207
25684575
8670882
10783161
12379659
10887184
17569879
21071413
8332195
7523381
10531446
24929361
8503013
16093354
19541618
10369681
8911690
18073111
11136732
10922060
7760835
11134016
|
NRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9867809
12750173
12932319
9001246
9665134
8805624
1386920
1639773
8340422
8601312
19595761
23331499
21071413
8332195
10531446
10882715
7811320
1996324
18988627
21779497
8636091
8503013
7766599
16093354
19541618
8180183
1708096
19933846
32296183
9525741
8876196
11136732
10205168
21478863
7760835
18775988
12917261
11134016
18641128
20080631
9488663
1990291
|
SRC
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
7692235
12551923
7517401
17097642
15258589
9689060
16189514
16630891
10998357
11376654
29063113
8876196
10205168
28846113
12952943
22592532
11134016
15710605
16170185
|
RAF1
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
8085158
12620389
16093354
19595761
7882972
16041367
24255178
11697890
7935795
8702721
10848612
16189514
25852190
7644510
12360521
10620507
|
RAF1
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
19608861
16093354
16041367
11697890
8702721
16189514
25852190
7644510
15459208
17979178
|
PDPK1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PIK3R2
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
HRAS
|
YWHAB
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
HRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
RASA1
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
10769036
11389730
23331499
18829532
7628625
9219684
10592173
8663024
16713569
26721396
8360177
8537347
1904555
10394594
2833817
|
SOS1
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
12628188
10208427
16713569
10913276
23331499
18454158
15507210
10592173
17673906
17496910
26721396
20133692
19141281
23132018
11560935
9447984
9690470
17084389
|
SRC
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12695509
9626657
9020108
25157176
33413561
|
SRC
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
11389730
1717825
16713569
|
IGF1R
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18988627
23331499
7642582
|
ERBB2
|
RASA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16273093
24412244
|
SYVN1
|
SEL1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
ACSN
|
12847084
16186509
18199748
18360008
19509052
|
SYVN1
|
SEL1L
|
â—¼ SHARES_COMPLEX
|
|
|
5.0
|
1.0
|
ACSN
|
12847084
16186509
18199748
18360008
19509052
|
KRAS
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
12068308
23352452
25907612
15035987
|
NRAS
|
YWHAB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
12068308
23352452
25907612
15035987
|
YWHAE
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20936779
17085597
12507503
24255178
17979178
|
IGF1R
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
15629149
17353931
19030972
14651979
17145710
16931767
9581554
12175651
|
AKT1
|
YWHAB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20138985
15169778
9812896
17680028
11756412
11923280
20214616
16697215
10949026
10722653
20832730
18570873
18372248
11715018
20398329
17052453
18636226
15808505
|
YWHAB
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20936779
17085597
12507503
24255178
17979178
|
PDGFA
|
SRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
7685273
9488729
10508235
9739761
|
SRC
|
PTK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
11476890
12531888
16919435
17496910
17517963
20027185
25572304
26552706
27216177
8892616
|
CAV1
|
SRC
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
11102446
17517963
18458534
19411448
20855962
21051947
21150282
21729786
22411312
22874531
23907124
25364523
26828520
|
ERBB2
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16769082
19617202
11940572
12753909
21075308
7542762
|
PTPN1
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
10698938
25585026
17092689
17974954
16537444
18332219
9600099
15866871
8647855
9261115
11346638
12857726
12468645
11007774
1646596
16115959
|
GNAI2
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23109003
11007482
11160627
10753828
9722546
|
PTPN12
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
19595712
18482983
|
EGF
|
SRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23349873
19481075
15845350
22927910
27462789
|
SRC
|
PLCG2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
30819914
12181444
11606584
14656219
7682059
15144186
11507089
|
SRC
|
ARRB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
17456469
17456551
16432186
|
SRC
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21780115
15032589
11526404
23109003
22880054
10488096
|
SRC
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17474147
9856337
|
SRC
|
PDPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
20643654
14585963
16314505
11481331
15212693
12738763
1148133
15302935
|
SRC
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
216.0
|
1.0
|
Omnipath
|
27351421
23242524
16254240
12370821
21940449
26142360
17525734
10593973
14604860
17389395
19171305
22402981
19339212
22353809
9748249
8941336
17570479
12464388
25226367
15611085
15817476
25241761
26393679
27978555
26833789
11927607
17828307
25913180
26866924
15247219
10085298
12387730
19055942
9507031
21454698
10973994
32814053
21057587
27931517
27438371
18793427
19695571
15735019
18560762
10592173
25319025
24389213
21852560
26689988
14984767
7505391
19568240
20103658
20822514
25868388
23275294
28423510
23764511
19625610
15561106
17192257
19138410
19369195
17088251
12753909
28701735
29190494
17016520
15598735
18814847
11821402
11418135
15728464
16291744
25067788
11602246
16713569
22287273
9032297
7997267
12960434
11369622
20616959
26079101
19534553
10931187
22710722
20068231
25866790
21347260
9822703
28202937
16153436
11980671
21855630
19826415
18464795
7529876
20621036
9330873
21473875
9425168
28956212
12615911
15951569
25814554
12876384
17438336
15212693
16966330
20705914
20847951
23729178
20407018
12558988
25127991
25918719
12590707
16360410
8054685
18814027
11696015
22800863
17117420
12495636
11278488
9864370
21776383
18083107
22814579
22194915
20515733
11119718
9148935
10428489
15743500
20655298
23065768
28213315
26923073
24015220
17289681
12110680
22006118
24164353
23109003
18935208
10753828
18233957
8816475
25118939
19664994
25530216
16760434
9330875
21266176
21034468
|
SRC
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
24728074
24034250
9837958
17570479
|
SRC
|
ITGB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
10330414
17473008
8631894
18156175
25694433
18840695
18364349
18398066
10592173
16935858
21956114
17353363
18088087
12359711
15212693
14996908
15695822
15699036
11723131
20702409
|
SRC
|
CAV1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
65.0
|
1.0
|
Omnipath
|
20201820
23469926
24755228
24525631
15592455
27259249
17979878
19409422
11075810
17389395
14992595
18578522
11094059
11451957
24244013
8632005
24131997
12921535
21324536
16332692
8621645
18815812
27170175
17517963
12531427
24632723
23091071
19625610
18789131
24502576
17016520
20107068
21382479
24364863
25937636
19604397
23280667
16713182
22596063
26169283
8910575
17190831
18707149
25097454
12036959
18176934
15212693
18400052
|
SRC
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
17389395
15212693
18691976
7559478
7493944
7537849
20068231
23472139
8550552
17016520
8940173
9480911
|
SRC
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
11413148
17081983
10358079
22090359
7925280
16189514
15702476
11641791
15212693
8617237
|
SRC
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
15784253
25364741
17400812
16957778
17627277
15140878
11032808
23065768
12736255
7539106
17921256
27472465
14963108
24487689
25275301
12630920
22865929
14766010
30148069
11013076
15020686
9500442
17284441
|
SRC
|
STAT5B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19438593
12429742
17997837
12621061
|
SRC
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
11445557
25241761
23242524
18283331
12600984
|
PDPK1
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PDPK1
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PDPK1
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
11687500
11747822
12670391
15802604
17680028
18802401
19109239
19122654
|
IGF1R
|
PDPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20044479
11054117
17570479
20643654
|
PDPK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
156.0
|
1.0
|
Omnipath
|
15505410
12538620
12176337
19951971
24352480
11752451
19401591
11369519
10698680
10601311
15718470
24950409
20481595
24169049
10570282
16798838
14993273
11500365
9368760
19844585
17680028
7637810
9169478
26256536
7722458
9094314
12750173
11438723
18802401
9252186
23331499
18456494
9104825
10592173
16189514
20361045
18988627
11278835
20163786
20333297
20041157
12808134
19602588
8630736
10207050
11241670
10438924
9868760
25912234
20153221
25582703
11445557
21775285
12149249
14666721
18596232
9512493
23397142
11809791
12167717
21798082
16033886
10679787
16787925
29562639
15550174
21071413
8978681
10833263
19203586
10226025
26937223
14500673
20161206
11136732
11825911
11042193
9642236
22569334
18662999
9736715
12242303
11313365
11598012
11134526
|
PDPK1
|
ITGB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
18578522
10896934
|
ESR1
|
CAV1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11773442
17535799
15033483
22031296
15496458
|
INSR
|
CAV1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9756945
10598578
12036959
17699617
|
PTPN1
|
CAV1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
16388599
12176037
16189514
|
ESR1
|
EGF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10894157
15075211
20889718
8770893
19423651
|
EGF
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15748904
23331499
12093292
11279155
|
ITCH
|
CXCR4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
28264927
19116316
24489825
|
CXCR4
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11668182
|
CXCR4
|
GNAI2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10508237
23109003
17084806
18538863
10644702
16183910
15337520
|
IGF1
|
IGF1R
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
11237532
12181198
17145802
19631971
|
ESR1
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17170218
20021813
16087727
19250214
10982795
24281069
18414489
15595626
|
WT1
|
IGF1R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
8390684
7497000
16698800
15345673
11001824
9076342
12444079
10499530
11896622
7791758
|
PTPN1
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
23331499
11884589
15976035
8702689
16926280
8999839
|
SOCS2
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
16574995
9727029
|
IGF1
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
21798082
23331499
8452530
21071413
12067807
1852007
21645859
8408032
14604834
19258508
11287679
23675206
19029956
2877871
|
IGF1R
|
IRS4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
9553137
18988627
11316748
|
IGF1R
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16931767
9111084
12175651
|
IGF1R
|
SIRPA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10842184
23331499
18233962
11779860
21799000
|
STAT5B
|
IGF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
16141355
20378540
17509524
20372799
11517160
12682066
22419735
24914937
20702579
14532269
20139685
15677453
18276757
|
STAT5A
|
IGF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
20378540
19920132
17509524
10050749
20372799
21651786
23071812
14532269
15677453
18276757
|
ESR1
|
IGF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
19920132
17166846
22739988
10750020
11566442
20372799
8206951
9014838
24914937
11457856
|
IGFBP3
|
IGF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
10823924
11600567
22578544
1383255
|
IGFBP4
|
IGF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
9722589
7683646
16924115
15642270
|
ESR1
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11029009
15569929
18450422
20664923
15496458
|
STAT5A
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24218138
24469394
18042802
20385773
|
AKT1
|
ITGB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
18578522
10896934
|
AKT1
|
PTPN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
17081983
18691976
11579209
16189514
10480872
|
AKT1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
18521086
26944939
11108261
17627277
20101208
17570479
15604293
23169992
26554417
16452229
15193262
7838153
12374744
11139588
26272591
11432835
20179234
11507039
9528769
|
AKT1
|
YWHAE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20138985
15169778
9812896
17680028
11756412
11923280
20214616
16697215
10949026
10722653
20832730
18570873
18372248
11715018
20398329
17052453
18636226
15808505
|
AKT1
|
PHB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
24522204
21689744
15173318
|
FN1
|
ITGB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
11423542
1694173
18480047
1532572
8663002
17015452
|
ITGB3
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
9169439
8649427
10545505
7657702
8636223
10022831
19339212
11927607
11940607
19161977
10592173
16919435
7529872
11553709
8755653
7512751
|
FN1
|
PTK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
12731048
18037882
19161977
19454690
19487819
20644254
20814939
22067905
22470492
24202395
9003039
9456329
9763606
9973479
|
ESR1
|
TGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11145955
8360257
11517191
10828826
22488924
18414489
9667651
|
TGFA
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10918572
|
MET
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
15611085
29435030
30134553
22188814
24043698
16782899
14572662
15247219
15561106
20802513
15598735
|
ITGB4
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12110680
10592173
7721947
|
PTPN12
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
19595712
10400703
9497381
21876001
11432829
11314030
|
INSR
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
9507031
17389395
19664994
20068231
17570479
17016520
7529876
16153436
|
ERBB2
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
17496910
19617202
25241761
10545505
7657702
27638858
19339212
27939360
15743500
20201928
12753909
16919435
16713569
7529872
12600989
11807823
|
PTPN1
|
PTK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
9418872
16291744
|
PTK2
|
ITGB4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12110680
10592173
7721947
|
WT1
|
INSR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16647191
16087727
11145562
12444079
9441865
8390684
|
PTPN1
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
109.0
|
1.0
|
Omnipath
|
10066179
12612081
11163213
17092689
11506178
15632081
8826975
8702689
16926280
14722096
8999839
23331499
8244979
15588987
11579209
16271887
10592173
1599438
9355745
11726652
12237455
10751417
17481567
21806020
19029027
1321126
12634852
11850117
10852715
15192089
10807907
16582879
17159996
|
PTPRF
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
23331499
7852302
10734133
15588985
11158333
10592173
1321126
8732688
19910497
8995282
1303753
|
PTPN12
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10734133
19167335
8454633
|
ERBB2
|
ARHGEF12
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
12220504
15210733
12196628
12730235
|
ARRB2
|
GNAI2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10508237
23109003
17084806
18538863
10644702
16183910
15337520
|
ARRB1
|
GNAI2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10508237
23109003
17084806
18538863
10644702
16183910
15337520
|
PHB2
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
15140878
17932104
26052702
10938099
12943695
|
ESR1
|
ERBB2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
24559156
16115928
16467118
17992604
19915977
15199112
21127199
21761336
21907803
20551150
11713584
1358436
20629094
18768663
19005469
9242384
20889718
10698518
16467117
|
ERBB2
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
15173068
|
ERBB2
|
PLCG2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16273093
25241761
|
ERBB2
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17496910
16273093
1334406
16729043
|
MTA1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
15226262
11146623
12527756
24413532
|
STAT5A
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11731618
22201800
11682624
11682625
|
ESR1
|
PBX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19376833
18414489
|
ESR1
|
PRL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
3481434
9259323
7649480
18022314
2082192
10830306
|
MTA1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
11146623
18451880
12167865
16807247
|
PTPN1
|
STAT5B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10993888
12237455
|
PTPN1
|
STAT5A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10993888
12237455
|
PTPN1
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
18579758
16537444
22789536
18819921
|
PLCG2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11390650
20484116
10811803
12471105
|
FGF19
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
SOS1
|
FGF23
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11353842
8780727
11447289
7559490
9182757
|
NRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
SOS1
|
NRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
7923364
11560935
9690470
21779497
8493579
|
PIK3R2
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3R2
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
STAT5A
|
PRL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
9341115
7479881
15778982
9773981
19036881
12060651
12819296
16847321
10406460
15637146
23313770
9806359
20124477
12459499
7744007
8018556
23729680
9545277
21964595
10373481
11682625
|
STAT5B
|
PRL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19014541
9528750
11721695
10373481
11682625
|
WT1
|
PDGFA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
15297375
1429549
7535092
8415628
7927908
7845666
22902878
1332065
|
STAT5A
|
SOCS2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12468433
22291912
16293640
|