Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
ERBB3 CSK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
FYN CSK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7524477 6730342
CSK CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16678999 6731761
CALM2 CALM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CALM1 CALM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CALM3 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12724311 21837266
CALM3 PPP3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15757646 293720
CALM1 CALM2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CALM2 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12724311 21837266
TP53 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FGFR3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
USP5 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CPSF7 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
LRP6 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 23371553
DVL2 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
DVL2 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
LRP6 DVL2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 16273260 23371553
SH3GLB1 SPART â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARRDC3 ADRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23208550 8428323
ADRB2 YWHAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ADRB2 ARRDC3 â—¼   COLOCALIZATION 2.0 0.8 intact 23208550 8428323
AGO2 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ANKRD13A LAPTM5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ARRDC3 HGS â—¼   COLOCALIZATION 2.0 0.8 intact 23208550 8428323
RCHY1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
EWSR1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
WWP1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATN1 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
EWSR1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WWP1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SFN BAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11574543 5214598
SMAD3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11906909 16603637
YWHAQ BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12426317 16713569
BECN1 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0810452105 19050071
RELA BECN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19289499 19458474
TNFAIP3 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20501938
SH3GLB1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21311563 17891140
SFN BRAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15778465 5217604
CAV1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16890161
UBE2K CBLC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ITCH CBLC â—¼   COLOCALIZATION 2.0 0.8 intact 12226085 5215735
CBLC ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CSNK2A1 CDC34 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5214488 11546811
MAPK8 CFLAR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18471544
RELA CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
TP53 COL18A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 COL18A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15958553
CPSF6 WWP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CPSF6 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
WWOX CPSF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217863 16055720
CPSF7 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FYN CSF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730431 7681396
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
CUL3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CYLD RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
CYLD IKBKG â—¼   DEUBIQUITINATION ✅ 2.0 0.8 Reactome 12917691 15620648
CYLD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17981138 19131965
CYLD MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29291351 18332137
DDX20 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NOTCH1 DTX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14567914 15965470
ITCH DTX1 â—¼   COLOCALIZATION 2.0 0.8 intact 17028573 5219205
UBE2K DTX3L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HGS EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20308550 0911188107
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
TP53 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
JUNB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12791272
NRG1 ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10768865 23365119
WWP1 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FGFR3 HNRNPL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 JUNB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC6 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
KDR FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
WASL FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11340081 16525419
GGA3 HGS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15611048 5217420
GSN RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC6 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MET HGS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 8380735
SF1 HNRNPUL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SH3GL1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MTSS1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PRKACA HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT UBA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRIM25 IFIH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18353649
MAP3K7 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219785 17363973
SMARCC1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RELA IKBKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12842894 5216511
IKBKB TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19196987 0812256106
RIPK1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21119000 18362886
IKBKB TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23589370 33548094
UBB IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RIPK1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10880512 5212735
TNFAIP3 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11389905 5214127
TP73 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15678106 5217499
NOTCH1 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8313469 19567869
N4BP1 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0701773104 17592138
ITCH SGK3 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218909 16888620
ITCH SH3GL2 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5216835 14684745
PI4K2A ITCH â—¼   COLOCALIZATION 2.0 0.8 intact 23146885 8426259
SH3GL2 ITCH â—¼   COLOCALIZATION 2.0 0.8 intact 5216835 14684745
SGK3 ITCH â—¼   COLOCALIZATION 2.0 0.8 intact 5218909 16888620
SMARCC2 ITSN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ITSN1 WASL â—¼   COLOCALIZATION 2.0 0.8 intact 5214632 11584276
JUNB MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15558021 15666830
KPNB1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
WWP1 LAPTM5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TNFAIP3 LAPTM5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
LRRK2 POU5F1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
LRRK2 SH3GL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22998870
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
MAVS UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
RASSF1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18566590
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
SMAD3 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15339794
TP53 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
MLKL PDCD6IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31138766 24316671
NCOA1 SCNN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17105732 20054001
NCOA1 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603
SMN1 NDFIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP63 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20442293 20950370
NOTCH1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17537801
RIPK1 PDCD6IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31138766 24316671
PDCD6IP RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31138766 24316671
POLR2C POLR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C POLR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
SMARCC2 POLR2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PPP3CB PPP3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 10195903 7593193
PRKACA SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAQ RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11697890 8005785
RAF1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 30761125 27554335
RASSF1 SFN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8009708 20069457
RCHY1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 5220017 17568776
RELA SFN â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TNFAIP3 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 20599425
TAX1BP1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
UBB RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TP53 SFN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7711923 20206173
SH3GLB1 UBE2G1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SLC1A5 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TGFBR1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511908 6798777
TGFB1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
TGFBR1 SMAD2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 10973958
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
SMAD3 SMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20123992 21965288
UBE2O SMAD6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8429180 23455153
UBE2O SMAD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23455153
SMAD7 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SNX9 SNX18 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23085988 8408210
WWP1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15221015
TP53 TNFRSF10B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11498783
UBB TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TNIP2 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
YAP1 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213829 11278685
TP73 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19815500 0905867106
TP63 WWP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18806757 20951678
WWOX TP73 â—¼   COLOCALIZATION 2.0 0.8 intact 5216996 15070730
TP73 WWOX â—¼   COLOCALIZATION 2.0 0.8 intact 5216996 15070730
UBB USP5 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 7851534
USP5 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26235645 16007098
YWHAQ YAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12535517 5216053
UBB USP12 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
NRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 34591642
NRAS BRAF â—¼   PROXIMITY ✅ 0.81 0.81 mint 30194290
WWOX ERBB4 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24550385 16061658 22584572 20943952 19047365
UBE2K MDM2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 23933584 21965653 30017913 15280377
TRIM25 UBB â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
IKBKG MAVS â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
PPP3CA PPP3CB â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
LRRK2 PCNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
RAC2 RAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CFTR CAV1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
RHOB CAV1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
CFTR USP9X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31324722 17110338
MAVS CYLD â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30410068 18636086
RHOB EGFR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
MET ERBB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21918175 25326665
LRRK2 GNAI2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20876399 31046837
TRPV4 ITCH â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17110928 20650893
RHOB LRP6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
LRRK1 LRRK2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20144646 19712061
TAB1 MAP3K7 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5218828 16845370
MAVS PCBP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25135833 19881509
RPAP2 RPAP3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17643375 24981860
USP9X YAP1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
UBB ZRANB1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
TNFAIP3 UBB â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
HDAC6 CFTR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31501480 14675537 22069321
RIPK1 CYLD â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33654169 22848449 28900035 17981138 21408173
WASL RHOJ â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25416956 31871319 32296183
SMAD7 TAB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12589052 11737269
SOX2 USP9X â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31605775 23667531
ERBB4 NRG1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
UBA1 UBE2E2 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
CALM3 EGFR â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MAP3K7 RIPK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
NEDD9 SMAD3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
UBB WDR48 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
SMARCC2 SMARCE1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
BCL10 IKBKB â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MDM2 TP63 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CFTR GNAI2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29924966 17110338
CYLD RIPK1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
TRPV4 FYN â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16713569 12538589
HGS UBA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19019082 25260751
CPSF6 HNRNPL â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
ITCH TP73 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DDX20 GEMIN8 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
GGA3 UBB â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
UBB USP5 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
HDAC6 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
DTX1 NOTCH1 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
CBLC ITCH â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12226085
WWOX CPSF6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24550385 32296183 16055720
ERBB4 ERBB3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7689552 10572067 25315821 20227043
GLI1 ITCH â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 20818436 31278361
MDM2 UBB â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TP53BP2 TP73 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
MDM2 UBE2K â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
LRRK2 DVL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31046837 19625296
LRRK2 AGO2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20671708 17400507
ITCH BIN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26613292 28235806
ERBB3 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
ERBB4 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
ATXN3 UBB â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
NRG1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 7514177
CBLC FYN â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
YAP1 YWHAQ â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
CALM3 PPP3CA â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CALM2 PPP3CA â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CALM1 PPP3CA â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
PDCD6IP SH3GL1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
IKBKG RELA â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 15489227
WWOX DVL2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24550385 33961781 28514442 30619736 25678599
ARAF RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 34017080 20130576 31980649
ITCH ATN1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9647693 16713569
ITCH CPSF6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 26508657 16055720
HDAC6 CYLD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20593489 19893491
EGFR WASL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
EGFR SNX9 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
EGFR HGS â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
LRRK2 LRP6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22899650 27013965
PPP3R1 PPP3CA â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 7295928 19896943
RPAP3 URI1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SMAD7 SMAD6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26555259 9256479
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SH3GL1 SH3GL2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SH3GL2 SH3GL3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CALM1 EGFR â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
SH3GL1 SH3GL3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TNFAIP3 TNIP2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ADRB2 ARRDC3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ARAF BRAF â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ARRDC3 TNFAIP3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CPSF6 CPSF7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IFIH1 MAVS â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MAP3K7 TNFRSF1A â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BCL10 IKBKG â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CALM1 CSNK2A1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
NRAS RAF1 â—¼   RELOCALIZATION ✅ + 0.87 0.87 Signor 21779497
ITCH TP63 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ERBB4 YAP1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ARRDC3 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CFLAR ITCH â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR SFN â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR PDCD6IP â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR SH3GL2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CAV1 CSK â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24632723 16678999 11805080
CFLAR RAF1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10837247 16189514 16537561 21988832
CSF1R FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 7681396 16713569
SMN1 DDX20 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 11714716 5214807
LRRK1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29513927 28065597 24947832
FGFR2 FGFR3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 23972473
MAVS IFIH1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33372174 16127453 19881509 21903422 30193849 17600090 22301138 27312109 33649232 22623778 19416887 32612200
IKBKG TNFRSF1A â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CAV1 EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CYLD IKBKG â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IGF1R MDM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IKBKB RELA â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TP53BP2 YAP1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
AMOT YAP1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
IKBKG TNFAIP3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NUDT21 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
UBA1 UBE2R2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCNA UBB â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
RCHY1 TP53 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RIPK1 TNFAIP3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
TAX1BP1 TNFAIP3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
DVL2 WWP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26701932 31340145 34139860
YWHAQ BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217174 15324660
BRAF YWHAQ â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CAV1 LRP6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16890161 28966723 34079125
WWP1 CPSF6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 19447967 16713569 28514442 16189514
EGFR TAB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18271526 31980649 25402006 24658140
ERBB4 ITCH â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18334649 17463226
RAF1 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7517401 16189514 16713569
SMAD3 JUNB â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220381 16189514 10903323
SFN RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 15778465 5217604
STK3 RASSF5 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24981860
TP53 RCHY1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 17568776 5220017
TP53 RCHY1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 17568776 5220017
CDC34 UBB â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
TP73 YAP1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
IKBKB TNFRSF1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
IKBKB MAP3K7 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
SMAD3 TGFBR1 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
POLR2A RPAP2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
EGFR CSK â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24797263 24658140 31980649 16729043 25402006
CSK PDCD1LG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12947224 18173375 18759926
CSK CD274 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12947224 18173375 18759926
BRAF ARAF â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 31980649 25241761 20130576 28205554 28628118 28514442 34017080 17979178
IKBKB BCL10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19909372 16301747 16356855
MAP3K7 BCL10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17158449 15327770 10882101
BCL10 TAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17158449 15327770 10882101
CALM1 TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12724311 21837266
EGFR CAV1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19446582 15657067 24658140 31980649 22411794 34079125 16407214 12354760 25402006 10781609 9374534 12388423 16799092 15273741
CAV1 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20462514 12529448 19923922
CBLC SH3GL3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CSNK2A1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14675149 25862939
SPOP CUL3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 25278611 22632832 16524876 21577200 19256485 29160310 28216678 22013077 21988832 25011449 30244836 19261606 31559706 22911784
NOTCH1 DTX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10933396 9881968 15356142
ITCH DTX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17028573
DVL3 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 20006983 19625296
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23436906 10527633 27756321 21278786 18803307 17148612 22439932 25315821 10572067 24189400 23866081
JUNB EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10803405 23455325
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
YAP1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16061658 15023535 25283809 12807903 19047365
ERBB4 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15985438
PRKACA FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20658524
FYN TRPV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12538589 16713569
SUFU GLI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20211142 32296183 21543335 25241761 31278361 10564661 25609649 10559945 29662197 24217340 12068298 22439934 24854174 29249966 12426310 24311597 16189514 27234298
TP53 HNRNPUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
HNRNPUL1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15907477
IKBKG IKBKB â—¼   PHOSPHORYLATION ✅ 3.0 0.9 intact 8209688 506093200 16126728
IKBKG RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15489227
ITCH SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15350225 23331499
ITSN1 SH3GL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ITSN1 UBE2K â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
KLF10 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22234868 12173049 12244575
PRKACA LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21262972 18981475 21406690
PRKACA LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21390248 24351927
MAPK8 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAP3K7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9380693
PCBP2 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25135833 19881509
SFN MDM2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8007833 17546054 1210540
TP63 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11714701 9405685 12374749
MDM2 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20571051
RELA MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19530226 20186924
MTSS1 SUFU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15545630 23331499
POLR2C NUDT21 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PDCD6IP TAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPAP2 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22137580
RELA TNFAIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11880364 19343319 10807933
RIPK3 RIPK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19524513 30420664 29497034 22864571 26786097 31358971 22817896 23744296 26559832 19524512 26319693 22265414 22265413 29352166 29883609 21903422 24098568 25882049 10339433
TNFRSF10B RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9430227
TRIM25 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12075357 16189514
SMAD2 TGFBR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SMAD2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27974707 11456453 16284942
SMAD6 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9892110
YAP1 SMAD7 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12118366 22921829 25283809
SMARCC1 SMARCE1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 20829358
TP53BP2 TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 21513714 8152471
TP73 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16413471 21436470 18026135
TP73 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11238924 19815500 10373484
TP63 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11278685 35044719
WWOX TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15070730
UBA1 UBE2C â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
UBA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17597759 24816145 21209336
BAX BID â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SMARCC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
RAF1 YWHAQ â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
LRRK2 YWHAQ â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
MLKL RIPK3 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
CDC34 UBA1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
POLR2C RPAP2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
UBA1 UBE2G1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
JAG1 NOTCH1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
RASSF5 STK3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
UBA1 UBE2L3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
ERBB3 NRG1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
POLR2B RPAP2 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
IKBKG RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
KPNB1 KPNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17596301
UBA1 UBB â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
ARRDC3 UBE2E3 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
ARRDC3 UBE2E2 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
MAP2K4 MAPK8 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
ARAF MAP2K1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
GSN WASL â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
NRAS RAF1 â—¼   PROXIMITY ✅ 0.93 0.93 mint 30194290
UBE2L3 WWP1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
UBB YOD1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
BRAF RAF1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
RASSF1 STK3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
NRAS RAF1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
BRAF NRAS â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ITCH DTX1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 18628966 17028573
ARID1A SMARCC1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
UBA1 UBE2K â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
UBB UBE2K â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
RAF1 BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 8396417 22510884
RAF1 MAP2K1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7014125 19197339
SMAD7 YAP1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
LRRK2 SFN â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
DDX20 SMN1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
CPSF7 NUDT21 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ITCH UBE2L3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
WASL ITSN1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11584276 18539136
MAP2K1 RAF1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SFN TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SMARCC1 SMARCE1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SCNN1A SCNN1B â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
TP53 TP53BP2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CPSF6 NUDT21 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
FLT1 KDR â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
IKBKB IKBKG â—¼   PHOSPHORYLATION ✅ 0.98 0.98 mint 8209688 16126728 506093200
TNFAIP3 TNFRSF1A â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CBLC EGFR â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
MDM2 TP73 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
KSR1 MAP2K1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ARID1A SMARCE1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
ARID1A SMARCC2 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
KPNA2 KPNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POU5F1 SOX2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPP3CA PPP3R1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
USP12 WDR48 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
BRAF MAP2K1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL3 SPOP â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCC2 SMARCE1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
IKBKB IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2C â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2B POLR2C â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
EGFR PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 21220489 24655521 23542172 29140271 28157503 26725162 22238610 25825764 17115032 26719139 28102297 22692198 28666590 25073158 20670598 20587074 23593472 25675097
CSK FYN â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10790433 11181701 12485116 15713798 19290918 8011291 8986721
IGF1R CSK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10026153
PRKACA CSK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9224730 11181701 20826718 31125786 12600271
CSK FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 1985196 8262983 11489946 16537894 9647655 25720756 18691976 10366594 19369195 1533589 1699196 7524477 16713569 15713745 14967142
EGFR CALM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 19901323 20029029 16497976 15592455 25402006 17389395 18578522 16799092 20068231 7925415 3415247 8639568 18669648 12153558 24658140 17287340 2843348 14960328 18707149 17016520
EGFR CALM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 19901323 20029029 16497976 15592455 25402006 17389395 18578522 16799092 20068231 7925415 3415247 8639568 18669648 12153558 24658140 17287340 2843348 14960328 15212693 18707149 17016520
DVL2 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
WWOX DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25678599 24550385 19465938
DVL2 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20006983 19625296
ITCH SPART â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16055720 19580544 20719964 19307600 19765186 20504295
SPART WWP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19765186 19580544 19307600
SPART ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16055720 19580544 19307600 19765186 20504295
PRKACA ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9461522 24003153 10753752 11146000 2987243 27481942 27646272
AMOT YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 32755583 21205866 26269582 21808241
ARAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18039929 8131746 8394352 24114843 15175348 15466476 94178255 7936666 7731720 7873542 7624324 8157000 8039496 8621729
MAPK8 ATN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17081983 12812981 15302935
TP73 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18034190 17346710 18421303 21245298 10559267 18418051 18644986 17521288 19067706 11748232
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
MAPK8 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525785 18471544 16709574
SH3GLB1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19074440 11161816 11259440 16189514 16227588
BID BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 20956295 17289999 25241761 19968986 15574335 10629050 19062087 10949027 12242151 23374347 14730312 17520191 8918887
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
IKBKG BCL10 â—¼   ENZYMATIC_REACTION ✅ 44.0 1.0 ACSN 11280761 11356195 11460167 12133805 12356734 14660645 15145317 15199157 15485931 15536066 16809782 16818229 16970925 17052756 17237376 17254973 17301840 17363905 17462996 17485448 17693255 17948050 18264101 18264787 18716620 19302050 20138012 20300203 20685844 21133840 21199863 21217011 21232017 21807870 21873235 22435554 23086447 23422957 23430059 24560716 24699077 24958845 2649237 28462531
BCL10 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14695475 19897484 18287044 27070702 17363905
TP53 BID â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12402042 16151013 18574470
CSNK2A1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11583622 12598529 20356928
MAPK8 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18594987 25326334 25077544 27374471
TP53 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15240700 12402042 18431400 15024076
KSR1 BRAF â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
KSR1 BRAF â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
PRKACA BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11510412 10931830
KSR1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19541618 8601312 19933846 12932319 17613518 18332145 15710605
NRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 1386920 21478863 9368069 19541618 8601312 14970219 18567582 16135787 7935411 12932319 12917261 17563371 19933846 21779497 8073291 15710605
BRAF YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16713569 8668348 17353931 15324660
BRAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 20212043 7706312 25437913 9560161 7936666 14970219 18567582 18332145 8413257 23331499 15342917 21071413 7731720 7873542 26496610 10976102 18988627 17667937 16255777 8131746 16888650 15485920 8394352 15175348 15466476 19541618 25600339 25155755 17563371 16810323 8157000 17979178 18039929 94178255 23934108 7835430 7624324 24746704 16135787 7935374 8039496 8621729
EGFR CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17145710 19901323 20029029 12359306 16497976 25402006 17389395 18578522 16799092 20068231 3415247 7925415 18669648 12153558 24658140 17287340 14960328 18707149 17016520
CSNK2A1 CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25108821 11827172 8206911 1520270 17173306 17329434 26675311 8639568
CAV1 TGFBR1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
CAV1 EGFR â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
FYN CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 9252391 29371975 11805080 12925753 21705803 12529448 11075810 15692085 14992595 8632005 10592173 16943184 12921535 16332692 12135605 20228056 15466865 33804982 24632723 33928090 18347068 34321069
EGFR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 31980649 22411794 9374534 19446582 16799092 12388423 15657067 24658140 19625610 16407214 18789131 25402006 15951569 10781609 16332692
CAV1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18988627 16189514 10066366
CBLC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10362357 22888118 17635922 10514377
CDC34 SUFU â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 16371461 16611981 16651270 17329932 18813803 9367342
CSNK2A1 CDC34 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11546811 12037680 16123592
RIPK3 CFLAR â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
TNFRSF10B CFLAR â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
RIPK1 CFLAR â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
CFLAR MLKL â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK1 CFLAR â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 CFLAR â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
CFLAR MLKL â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK1 CFLAR â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 CFLAR â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
ITCH CFLAR â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 21107885 21383157 26972597
CFLAR MLKL â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RELA CFLAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19343319 18073330 18222423 15986355 15723831
ITCH CFLAR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 30736843 16469705 19090833 18786561
CFLAR RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12887920 11002417 17047155 10837247
PRKACA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 28003367 23060444 25867080 21455600 30600261 1716180 28242698 19328185 32102849 92316961 19095655 14602047 7530719 10581361 11053017 9385646 25330774 15657296 1377674
CSNK2A1 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21930781 17289674
NUDT21 CPSF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 16189514 25416956
CSNK2A1 DVL3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2A1 UBE2R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12037680 18669648
SPOP CUL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21988832 23331499 19256485 28216678 21577200 25011449 34599168 22911784 15897469 22013077 16524876 19261606 25278611
IKBKB CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19481526 24614225 15870263
CYLD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21988832 15341735 15870263 22990857 12917689 12917691 16627981 20932475 26802121 12917690
DTX1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11153911 20208568 23331499 21071413 11226752 11564735 22162134 18988627
LRP6 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
TP53 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20190820 18359760 9664135 10029407 8152794 11713584 8887630 9285564 19597475 11546792 1586628 18604200 18391986
PDCD6IP EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 31980649 15456872 12771190 24658140 15557335 25402006
TGFB1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20953304 32103204 19132220 28943431
RIPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11116146
SNX9 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16316319 24658140 25402006
EGFR SCAMP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15144186 9658162
EGFR MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12556561 15531749
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR LRRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24947832 22337768
EGFR HGS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12953068 17016520
EGFR HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20133936 31980649 22896792 20029029 24658140 21151618 25402006 23084749
NRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10970856 16843264 7514177 7592681 23331499 8702572 7477375 11555649 9565587 16189514 26148232 9168115 9275162 10214951 17697999
NRG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 9275162 7721889 25052836 10970856 10214951 8062828 9565587 14967450 10537356 9168115
ITCH ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18334649 17463226
SF1 EWSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9660765 16713569
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TP53 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16432214 20080630 17242190 20422012
KDR FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FYN KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9038210 9799234 12374739
FYN ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16387660 17053785
GLI1 SUFU â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10559945 11001584 11960000 17638910 18754008 19055941 19081070 19684112 22354771 23031257
GLI1 SUFU â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 10559945 11001584 11960000 17638910 18754008 19055941 19081070 19684112 22354771 23031257
SMAD3 GLI1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
ITCH GLI1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10940313 11318614 16469705 16861923 17115028 17312394 18552861 18628966 20818436 20940030 21107885 21383157
GLI1 PRKACA â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
GLI1 PTCH1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257
GLI1 PTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19860666 21076395 11719506 16571352 15087129
ITCH GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18552861 17115028 20818436 20940030 17312394
MTSS1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15545630 23331499 17845852
SUFU GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25609649 19055941 20211142 10559945 11960000 24854174 15367681 23331499 27234298 24311597 21071413 12426310 16189514 18988627 24217340 25241761 32296183 10564661 22439934 21543335
PRKACA GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16481469 23331499 20027184 16293631 19996099
GLI1 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16158046 18813803 19219074 16880536 21059263 11960000 19190345 15087129 21442356 16328026 19736394 11001584 12138125 20107231 15520176 16406505 17000779 16571352 16396903 14555646 17035233 16054035
HGS SH3GL2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
HGS SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11094085
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
IFIH1 MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19416887 22301138 17600090 17020950 19052324 21903422 16410796 16785313 16713980 23499489 16127453 33372174 16125763
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
MDM2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 25241761 28092675 12821780 18632619 17303558 19165858 36042202 20195357
IKBKB MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
IKBKB RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
MAP3K7 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 24911653 11129660 25195736 16006187 16260493 15502405 14530355 10779355 28159912 10094049 10837071 15836773 25659581 10195894 9689078 17363973 10807933 15214841 16186825 16493424 10022904 18316610 10187861 12547194 33895773 28475177 16301747 15691841 15620648 15327770 29748387 19632174 11460167 17965022
IKBKG IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 150.0 1.0 Omnipath 17145710 16938294 20932476 35339487 18266324 16260493 27929056 25979343 19666608 26496610 12133833 12192055 9751060 21423167 19706536 15836773 17561400 22099304 23986494 19959994 15327770 25400026 24266532 18450452 12657630 20434986 11583588 20200955 20300203 21903422 22990857 14743216 20167598 20098747 16126728 19656241 25852190 16906147 10195894 17000764 18329793 16186825 16547522 16611882 18037881 10968790 16497931 25286246 18462684 18207244 16603398 17965022 17977820 24240172 17568778 15084594 16129692 23506214 16319058 23123196 18949366 15218526 22605335 20368414 10837071 19820708 10980203 23131831 17363973 15214841 25304104 16493424 15184390 15691841 11864612 15802604 17693255 21455180 11865184 20211142 11971985 16970925 24469399 24618592 12486103 11057907 24369075 19365808 18583959 27426725 12612076 19422324 10094049 23109003 21803029 12459277 21640763 16285893 18266467 12709429 15620648 17072322 19815509 15749833
MAVS IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 16177806 16153868 21903422 17468758 18207245
IKBKB RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 135.0 1.0 Omnipath 15280197 17785205 27329558 22110409 22753932 22205033 21765477 15611068 18519641 15858576 25241761 33579825 23536830 28122346 19393267 34556881 24442433 14560022 15192014 21242976 16840782 19609947 33789981 10521409 26826124 21492457 19110719 23303310 16105840 22212641 26587973 34219129 15210811 16046471 11359840 27626700 15128824 28416608 17178723 21674813 17362989 28737909 19377466 15980040 16407239 15849198 20507904 26082493 15557193 34082140 21798539 26267322 29363544 12767944 20224721 26307684 12842894 17108032 26170389 24336331 27315556 31980577 11259436 34380537 20872791 21674474 15465828 15994321 17548605 26603838 16148147 25136068 33914760 26569329 22234699 17012367 14636585 22039465 32123095 15212693 27466442 33883226 15611276 22081069 19197368 17070014 20051109 26693062 14963024 33971703 28381553 33459422 27244888 18544167 18922932 20188669 15485852 20696864 22689577 17982102 20410276 15489227
RELA IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
RIPK1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
MAP3K7 IKBKG â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
IKBKG TNIP2 â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
IKBKG RELA â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
RIPK1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10880512 21383699 21458669 14653779 10980203 17702576 9927690 16603398 16547522 16965765 10755617
MAP3K7 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 24911653 11477091 17301840 18180283 19909372 15125833 24699077 17363905 16356855 18641653 24403530 18079694 18223652 14514672 17496917 19531477 20300203 11325957 21133840 21232017 18264787 9744859 10391247 16799562 15836773 10702308 23109003 12620219 14633987 17363973 19161412 22941947 23681101 17047224 29145629 11280761 16301747 15082531 26192618 14660645 20038579 24958845 15327770 20164171 11460167 16603398 21041997
TNFAIP3 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 21988832 11389905 22099304 23032186 20932475 26802121 31585000 10755617
TNFRSF1A IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 10755617
ITCH YAP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 21107885 21383157
ITCH RIPK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 19131965 20068034 21107885 21383157
PCBP2 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19881509
N4BP1 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17592138
MAPK8 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23435430 16469705 15358865 16446428
ITCH MAVS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19881509 27736772
ITCH TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16861923 23370280 16908849 25485500 20855944 22935697
ITCH SH3GL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14684745 17038327 26613292
ITCH NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12682059 10940313 23331499 16713569
ITCH TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15678106 11318614 10940313 17110958 17592138 21107885 19788416 21383157 18628966 16861923 11278685
ITCH SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 21071413 19030025 15946939
NOTCH1 JAG1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   LOCALISATION ✅ 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
TP63 JAG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23863842 11641404 23837456
JAG1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18495817 16921404 15137944 769772111006133 16713569 23331499 21071413 23086448 22363130 18988627 21820430 18292500 18660822 22330899 17537801 11006133 7697721 10958687 22353464
MAPK8 JUNB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8917518 18669648 9889198 20068231 9405416
LRRK2 KPNB1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
PPP3CB KPNB1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19136967 19836308 21278340 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
PPP3CB KPNB1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19136967 19836308 21278340 21709260 21983832 7650486 8068174 9374532 9973469
TAB1 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 7650486 9973469
LRRK2 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
KPNB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11294908 10846168
RAF1 KSR1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
NRAS KSR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAP3K7 KSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11741534 12941695
KSR1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8503013 19541618 15090600 11741534 1330321 17613518 11940661 18332145 7992057 8248196 15520859
KSR1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 7477354 12932319 9665134 9094715 19766101 23331499 8601312 19595761 11478855 8332195 15520859 8503013 16093354 19541618 19933846 10205168 7760835 18775988 18789263 11134016 8180183 1990291
PPP3CB LRRK2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
PPP3CB LRRK2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
PPP3CB LRRK2 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 SH3GL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 25501810 24778241 22998870
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
RAF1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 143.0 1.0 Omnipath 10757792 18337766 18799465 15342917 23728975 26496610 15866172 17053865 11242034 9351825 9677429 8157000 7992057 11948414 11604401 16129686 10677502 12695496 19197339 7565670 12750173 7936666 1326789 19219045 23331499 18556463 10976102 18988627 15485920 15175348 18691976 16407412 10409742 9311917 17192257 7898932 8621729 23934108 11684694 21336309 7624324 12920017 11948406 15466214 11042690 12907640 9032297 27169363 12876277 8933152 8223433 8248196 8131746 12594221 10969079 10567369 17979178 17724343 24746704 19058874 10958680 8090753 21071413 7731720 7873542 1330321 8503013 16093354 19541618 8394352 15466476 25155755 11136732 9069260 94178255 8607979 10327068 10359597 8039496 20212043
MAP3K7 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
RIPK1 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TGFBR1 MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530
TNFRSF1A MAP2K4 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
TNFRSF1A MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
TAB1 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20060931 21614932 12738796 11274345 18855897
MAP3K7 MAP2K4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 11477091 17301840 13130464 18855897 15125833 24699077 9278437 17363905 18641653 24403530 20060931 21133840 21614932 9891069 12738796 21232017 9851932 18264787 10391247 16799562 23109003 12620219 14633987 12709432 8177321 19161412 22941947 23681101 12556533 11280761 15082531 26192618 14660645 24958845 20164171 11460167 16603398 21041997 11274345
MAP2K4 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 17143273 10713157 11489946 7600581 8702918 17145710 13130464 23416355 10748139 8805275 18855897 10791986 9108083 19690332 95141073 18083107 9724739 12788955 9305638 23331499 19534553 15068801 7839144 10958661 21071413 23047924 11062067 21614932 9808624 12738796 15911620 15998799 9891069 11389443 18988627 9733714 11847100 18669648 16153436 10521444 15302099 16282370 11242034 14523011 12709432 26370088 9661668 10499589 7652575 16076903 7992057 16440308 7600582 17192257 9860979 15755722 12133933 16533805 19369195 9312068 9207092 10385525 12354380 12917261 8910292 9487126 9448004 10962008 12624093 11274345 11099046
RIPK1 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TAB1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16289117 18180283 10838074 24912525 23934659 10882101 19556242 11259596 19026643 14670075 17299140 23331499 22158122 12372426 21903422 17560374 21071413 23180781 19775907 14743216 17348859 20200282 26432169 18988627 10094049 8638164 11809792 10702308 25241761 19232515 14633987 18456659 10921914 20538596 15590691 16845370 27468689 12975377 12242293 17172402 22167179 12429732 12624112 12859960 16260783 11460167
SMAD7 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12589052
SMAD6 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11737269 10748100
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
RET MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18669648 9312068 11062067 15911620 95141073 16153436 15755722
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
MAPK8 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15071501
MAPK8 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10601313 25714018
MAPK8 WWOX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15580310 12514174 18371080
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
TP73 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20921405 15734740 20156675 10469568 11245471 10207051
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19805293 22056774 17290220
MDM2 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 18499675 17700533 26025930 25417702 19218448 21088494 10321734 10469568 10435614 20588255 25301064 10207051 11223036 21261729
RIPK1 MLKL â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 MLKL â—¼   PHYSICAL_INTERACTION 55.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK3 MLKL â—¼   SHARES_COMPLEX 55.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK1 MLKL â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 MLKL â—¼   ENZYMATIC_REACTION ✅ 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 MLKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 27826146 24434512 25493335 26024392 28126382 26866270 34155344 27959630 24901049 27832137 26184911 30029665 26967968 29026104 24703947 28807105 27941671 23612963 24012422 29484439 22265413
SMAD3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 16713569 14638857 18988627
NRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 9867809 12750173 12932319 9001246 9665134 8805624 1386920 1639773 8340422 8601312 19595761 23331499 21071413 8332195 10531446 10882715 7811320 1996324 18988627 21779497 8636091 8503013 7766599 16093354 19541618 8180183 1708096 19933846 32296183 9525741 8876196 11136732 10205168 21478863 7760835 18775988 12917261 11134016 18641128 20080631 9488663 1990291
TGFB1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19010789 16474430 17934056 18403754 20519943 16607286 21900405 11133108 14557817 15548370 19920116
POU5F1 SOX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20505756 12136102 17324942 15988017 17068183
PPP3CB TAB1 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 7650486 9973469
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
PRKACA SUFU â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
PRKACA RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20682772 15966897 17050626 11886862
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
PRKACA SUFU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 27234298 16611981 20027184 21209912 29371981 23337587 21317289 14611647
PRKACA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19007248 11971957 20166139 18767875 20230923 9001246 10576742 23331499 20068231 7935389 18669648 18691976 9922370 15664191 19651622 12801936 9091312 10862777 9710607 11997508
YWHAQ RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 14688280 7760835 17353931 16041367 11697890
RAF1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24929361 15618521
RAF1 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16093354 26578655 35044719 16041367 15778465 11697890 25852190
RAF1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 14688280 7760835 17353931 16041367 11697890
TP53 RASSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23779024 23038753 21364923
RASSF5 RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11857081 16713569 22195963
RASSF1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17379520 24366813 26186194 14729613 22195963 24255178 20920251 21808241 21199877 19962312 20086174 32296183 17598981 29063833 18347058 17889669 23455922
RCHY1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 21988832 19483087 17568776 24367557 25116336 21084285 12654245 21791603 20452352 19043414 16713569 31630802 27519799 19918835
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RELA TNFRSF10B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18523266 18599488 19351839
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
TNIP2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 14743216
RELA TP53BP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18448430 16713569 10498867
RIPK1 RIPK3 â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
RIPK1 TNFRSF1A â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
RIPK1 RIPK3 â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 RIPK3 â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
TNFRSF1A RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 25681446 11002422 20547836 8612133 18450452 27552911 26802121 10356400 19773432 18621737 23815148 16611992 22179575 12721308 21741934 7538908 18949366 21113135 8985253 10744744 10795740 21119000 22733818 10755617 27321185 15115707 24098568 18939944 18329793 20825417 20448643 15357952 21737329 12887920 24130170 15258597 24758719 16115877 19524513 18724939 16968706 22817896 28817177 18022363 19815541 25388546 21331078 22848449
TNFAIP3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20448643 17703191 18246070 15258597 19131965
RIPK3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11734559 21903422 22265414 19524512 19524513 22817896 26559832 10339433 26319693 11585904 22265413
TP63 SFN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12640112 17404570
TP53 SFN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18281511 10101800 22427654 12640112 17404570 12447694 17361185
TP53 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20206173 17546054 18431400 21340684 20066118 20457558 20182602 11896572 6396087 14517281 21625211
SFN YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD2 SMAD7 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
TGFB1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFBR1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD2 SMAD7 â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD2 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15183844 10887185 10753944 10843994 10559222
SMAD7 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17438144 21071413 9892009 9892110
TGFBR1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 10678166 12220225 9892009 9463378 16024789 9136927 14625308 11792802 11133108 19920116 14557817 11278410 15134444 10085140 23331499 21071413 20060931 17934056 18511908 21614932 18988627 10973958 23221174 8980228 9311995 9346908 9235954 20519943 21900405 15350225 15548370 26057631 19010789 15104092 16474430 9346966 30093905 12957874 11744690 9525694 15212693 11274345 9865696
SMAD6 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9256479 21071413 9892110
TGFB1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15548370 19010789 10678166 16474430 9311995 23831640 17934056 20519943 24075003 11792802 11133108 21900405 14557817 11278410 19920116 9865696
WWP1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15221015 15946939 15359284
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SMAD7 â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFBR1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SMAD7 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
SMAD3 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10823886 15183844 12761881 10887185 10973944 10839991 10753944 10843994 15579469 10559222
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
TGFBR1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15104092 9311995 8774881 25714018 11438668 19458083 11792802 12957874 19701891 9380693
SMAD7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 9892009 26555259 9892110
SMAD6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
SMAD6 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11278251 23331499 22921829 9335505 21897371 22286770 20663871 9335507 15761153 12151385 11163210 9215638 9892110
SMAD7 TGFBR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
SMAD7 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
TGFB1 SMAD7 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SMAD7 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10887185 15855807 9886263 20631490 22656308 19214138 23633623 14600158 10753944 11912247 11385614 11180003 17928287 19010789 22496417 22841502 17074765 15496141 11448947
YAP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 22921829 12118366 25283809
TGFB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 14718519 16474430 17934056 20519943 9335507 21900405 11133108 14557817 15548370 19920116
WWP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15221015
SMAD7 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9335505 21897371 9335507 17314099 12151385 9892110 23331499 22921829 21071413 21791611 18988627 11278251 16571110 14657019 18725536 15761153 11163210 15221015 30017632 22286770 15148321 20663871 14722617 9215638
SMAD7 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
TAX1BP1 TNFAIP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18246070 34454289 20599425 23018911 32296183 10435631 18239685 11389905
TGFB1 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TGFB1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22326956 10187774 7852346 22703233 12809600 7706250 11323414 8047140 8235612 26194464
TP53 TNFRSF10B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10777207 10101800 11756185 11139340 15964798 22046379 10810622 14585074 19351839 11313989 10597242 17278883
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53BP2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 14985081 16139958 8875926 25502805 8016121 21513714 31515488 16713569 8668206 18275817 11839776
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
TP53 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11238924 18431400 21508668 9891077
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP73 TP53BP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11684014 18676979 14729977 18275817
YAP1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 15678106 17110958 35044719 19111660 19788416 21808241 18280240 18640976 25283809 15893728 11278685 17889669 27292796
TP53 KDR â—¼   KO_UP_REGULATES ✅ + 1.12 1.12 PKG 28854368
TP53 BAX â—¼   KO_DOWN_REGULATES ✅ - -1.43 1.42 PKG 28854368
TP53 NOTCH1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368
TP53 TNFRSF10B â—¼   KO_DOWN_REGULATES ✅ - -1.59 1.58 PKG 28854368