Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
LRRK1 ABL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8010101 20697350
ABL1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10601328 19564926
ABL1 DAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
ABL1 DNM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 LIG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17893873
APEX1 ACTB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16431169 11082319
ATP2A2 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
LRRK2 BAG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
SQSTM1 BAG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7263374 19229298
BAG3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
BAG3 DYNC1H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BAG3 SQSTM1 â—¼   COLOCALIZATION 2.0 0.8 intact 7263374 19229298
BAG5 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20223214 15603737
SFN BAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11574543 5214598
BAX SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BAX GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0912742107 20080742
YWHAQ BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12426317 16713569
HSPD1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18266962
YWHAB CDC25A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220486 7644510
YWHAZ CDC25A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
CDC25A MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15672448
YWHAZ CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
DVL2 CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17199046 12958364
CLTC TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DNAJA1 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DNAJA1 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAZ DYNC1H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
MAPK8IP2 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
YWHAZ EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217069 15225635
EGFR YWHAZ â—¼   COLOCALIZATION 2.0 0.8 intact 5217069 15225635
USO1 GAK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
YWHAZ HSPD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
HSPD1 SAFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPD1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPD1 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPD1 FADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
IMMT SNAPIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PRKACA IMMT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27153535
YWHAZ IQGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
IQGAP1 TUBGCP2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 15263019 22573807
STUB1 LIG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18313385
LRRK2 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
MAPK3 CASP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219611 17290218
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
PPP1CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
MAPK3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19046355 9614189
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
GSK3B MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
MAPT CDK5 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
YWHAZ PFKP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
RIF1 PFN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 HSPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 MLLT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
YWHAZ RPL19 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
SFN IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15778465 5217604
SFN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20005908 8009659
HSPA1A SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DAPK1 STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
STUB1 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STUB1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19940151 25637186
YWHAG C1QBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
C1QBP TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
C1QBP YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
ACTG1 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
EEF1A2 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CDK5 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ACTR3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYH9 EIF2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TUBB4A RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA9 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RIPK1 TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CUL1 UBE2M â—¼   NEDDYLATION ✅ 2.0 0.8 intact 17914462 6175264
DUX3 DAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
DAPK1 TUBB4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
DAPK1 CDC42EP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
DAPK1 SNX9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
DAPK1 MRGBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
CASP8 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP8 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10409650 10911620
DVL2 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17199046 12958364
TUBB TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A6 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB4A TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RAC1 PRKN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAC1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19132225 20001745
TUBB YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
LBR YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAB APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DVL2 RHOA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11779461 18162551
RHOA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RHOA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15884057 11748077
LRRK2 CUEDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 CHGB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 ARFGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 ANKS4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 CDC42EP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
LRRK2 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
LRRK2 SH3GL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22998870
LRRK2 ARFGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22423108 22363216
LRP6 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 23371553
GOLGA2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
DVL2 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LRP6 DVL2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 16273260 23371553
HIF1A WSB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 23792163
SENP3 HIF1A â—¼   COLOCALIZATION 2.0 0.8 intact 7941484 19680224
HIF1A MTA1 â—¼   COLOCALIZATION 2.0 0.8 intact 5218395 16511565
CDC42 EIF2AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7738010 5220554
CDC42 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704645 14724572
PPP1CA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8288823 20186153
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AKT1 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15539407 20606012
PPP1CA AKT1 â—¼   COLOCALIZATION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288823 20186153
CDK5 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAZ CSE1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
CSE1L YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG ARHGEF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
ARHGEF7 TUBB4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CHGB SLC25A6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CHGB TUBB2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LBR YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
HSPA9 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
PPP2R2A APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DVL3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP1CA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TUBB APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP HSPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARFGAP1 RGS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SNCA AP3B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPB1 RPS15A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAZ RPLP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
LDHA YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
SH3GL1 DNM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10542231 5211933
SNX9 DNM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217519 15703209
SNCA GSK3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21985244 8209944
HSPA4 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PPP1CA PFN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22479341
CRMP1 PFN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HSPA9 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAH SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AGO2 AGO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16756390 0040210
PRKN MFN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1231031 23620051
MFN2 PRKN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1231031 23620051
PRKN MFN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25915564 29921586
MFN2 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25915564 29921586
PRKN RGS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
YWHAZ HSPH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PFN1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
TUBB1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
ECHS1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAB YWHAG â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
IRS1 YWHAB â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
IRS1 RPTOR â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16354680 19561084 30240640
AP2A2 GAK â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
APP SNCA â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
ACTB DYNC1H1 â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
BAG2 HSPA1A â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
LRRK2 STUB1 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
PPP1CA RIF1 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
EGFR APEX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24780295 28065597
APEX1 RIF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 28986522
EGFR ACTB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
LRRK2 RIF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 23075850
C1QBP LBR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32877691 28565870
SNX9 AP2A2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RAC1 LBR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
LRRK2 RHOA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 21454543
LRRK1 LRRK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19712061 20144646
TCF25 LRRK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24947832
LRRK2 HSPB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24725412 29519959
LRRK2 CDK5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 26268594
LRRK2 LDHA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 AGO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20671708 17400507
LRRK2 AP3B1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24725412 27424887
LRRK2 SENP3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 COPG2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
PSMD5 BAG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26344197
TUBB2A TUBB4B â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
ELOC WSB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18187417 19159283
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
EIF2S3 RPS17 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
RPTOR BAG3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
HERC2 BICD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 28718761 25476789
MAPK3 HSPB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 21575178 8774846
PRDX3 OPA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
OPA1 LRRK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24282027 31046837
MYH9 ACTB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22366308 16186248 26496610
EIF2S3 RPS3A â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
SNCA YWHAH â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
LRRK2 YWHAG â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
ABL1 EGFR â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
GAK CDK5 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 9013862
RAB8A LRRK2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32017888 26824392
CDC42 PRDX3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31478661 26496610
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
GSK3B MAP2K7 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
LRRK1 ABL1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29513927 24947832 20697350
HIF1A APEX1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10594042 16189514
EGFR AP2A2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24797263 8548289 24189400 23956138 31959764
LRRK2 CDC42 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21048939 21454543
RAB32 RAB38 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 33961781 31552791 26186194
LRRK2 RPS15 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
EIF2S3 RPS20 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
AMOT BAG3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19615732 25036637
GSK3B STRAP â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 21502811
FADD DAPK1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25241761 15048887 12911633
RAC1 LRRK2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31046837 21454543
LRRK2 AGO2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20671708 17400507
LRRK2 DVL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31046837 19625296
HSPA9 HSPD1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
EIF2S3 RPS13 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
MAPT YWHAB â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
ARHGEF7 CDC42 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
EIF2S3 RPS15 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
DAPK1 BAG2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29513927 25852190
EGFR SNX9 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
CASP8 TRADD â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19524513 18776134 17047155 12887920 29108854 30561431
RAB10 LRRK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31046837 26824392
LRRK2 LRP6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27013965 22899650
ACTB MAPT â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HIF1A HSPA4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EGFR YWHAZ â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
LRRK2 RAB5B â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HSPA4 SNCA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
TUBB TUBB2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ARHGEF7 RAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR SFN â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HSPB1 BAG3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 30559338 26496610 32814053 25277244
LRRK1 BAG5 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24510904 24947832 29513927
CDC25A CUL1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
PTK6 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8940083 22973453 16273093
LRRK1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24947832 28065597 29513927
EGFR HSPB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24189400 23397142 15657067
CASP8 TRADD â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CDC42 RAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
RAB10 RAB8A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17353931 26344197
ARHGEF7 ITCH â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
LRRK2 YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAG YWHAZ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAG YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
HSPA4 MAPT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
YWHAB YWHAH â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
YWHAH YWHAZ â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
YWHAB YWHAZ â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
DNM1 SNX9 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BAG1 HSPA4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BAG1 STUB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
DVL2 BAG3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31340145 16189514 16713569 21516116
LRRK2 BAG5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24510904 24947832 19001729
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
GAK LRRK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24510904 24947832 26375402 29513927
RAC1 IQGAP1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 18809683
MYH9 MYH10 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 16596254 26496610 24981860
RIPK1 FADD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11854271 23972990 24098568 33469115 11002422 26733177 19524513 26865630 32296183 22864571 27560715 23744296 32024820 21183682 30561431 21052097 19373245 24577083 21458669 21737329 32707033 21525013 22848449 29497034 33961781 26186194 26972597 21620750
TRADD RIPK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8612133 24735611 27768232 21724995 16603398 30561431 23429285
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
RAB32 LRRK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31552791 25360523
DVL2 DVL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 31340145 33961781 28514442
GSK3B LRP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19107203 16890161 16365045
HIF1A MTA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16969516 16511565
AKT1 HSPB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17510053 31980649 12740362 11042204 23397142
ABL1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 16273093 25402006 7678409
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGFR HDAC6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20029029 31980649 24658140 20133936 25402006
MRPL44 IMMT â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK3 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
MAPK3 PPP1CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MAP2K3 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8226933
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPT STUB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
YWHAZ SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23840115 15161933
YWHAG SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15778465 15324660
SFN YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15778465 15324660
SFN YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23840115 15161933
CASP8 RIPK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27810922 23972990 24098568 33052227 14681455 19773432 33469115 18485876 22274400 26733177 19524513 22864571 29431638 25939870 19524512 11002417 18570872 29021293 27552911 29274253 22179575 22173242 19373245 25911380 22585859 21737330 24577083 21458669 21282461 21737329 20825417 19060883 32707033 21525013 23429285 10521396 17047155 12887920 23955153 26972597 12215447 12884866
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
PPP2R2A DAPK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 085076 20220139 8204016
DVL3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12533515
YWHAG YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17085597 15324660
YWHAB YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17085597 15324660
RHOA PFN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22820501 22479341 27228149
LRRK2 RAB5B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27314038 18445495 25605758 26355680
LRRK2 PRDX3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31046837 21850687 24459295
DVL3 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 20006983 19625296
PRKACA LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21390248 24351927
PRKACA LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21262972 18981475 21406690
HIF1A ELOC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21658608 17558023 12050673 17244529 12004076 19940151 18323857 17353276 17965024
HIF1A HK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19828020 19689405
HIF1A HK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11557773 14672622 16782875
CDC42 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9574518 9305638 23109003
MAP2K7 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17360977
EIF2AK2 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 30071259 20685959 28779021
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
CDK5 PPP1CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 010002200 11320080 8286802
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
WSB1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EIF4EBP1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B CRMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16611631
HDAC6 NASP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RGS2 CRMP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CRMP1 MAPK8IP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YWHAZ SH3GL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AGO1 AGO2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16756390 24086155 24778252 33961781 15908945 29395067
EIF2S3 RPS15A â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
CDK5 MAPT â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CASP8 RIPK1 â—¼   CLEAVAGE ✅ - 0.9 0.9 Signor 10521396
LRRK2 YWHAQ â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
MAPT YWHAZ â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
LRRK2 YWHAZ â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
BAG3 HSPA4 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
HSPA1A STUB1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
BAG3 HSPA1A â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CASP8 RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
IQGAP1 RAC1 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
CDC42 IQGAP1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
BAG5 HSPA1A â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ACTB PFN1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
TUBB YWHAZ â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
IQGAP1 CDC42 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5221163 8798539
CDC42 IQGAP1 â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 18809683
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
DVL1 DVL3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
EIF2B1 EIF2S3 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
MRPL44 MRPS9 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
TRADD FADD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24686082 32296183 12107169 12796506 8681376 21724995 12911633 23955153 11112409 16919273 8565075 30561431 10911999
LRRK2 SFN â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CLTC GAK â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
MRPL27 MRPL44 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
MAPT PRKACA â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CASP8 FADD â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 5219431 17159907
GSK3B YWHAZ â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CUL1 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPL34 RPLP2 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
MRPL27 MRPS9 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CWC15 SNRPA1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPL34 RPS17 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS15 RPS20 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
FADD CASP8 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21785459 23142077 21988832 23972990 17290218 24098568 14681455 20103630 33469115 18485876 22274400 22864571 25043603 27560715 25939870 29795330 19524512 17159907 30561431 27552911 19176810 15659383 9343261 22179575 22173242 25911380 27321185 8681376 15280356 21737330 26437781 31046799 21458669 12702723 11717445 21737329 19060883 21525013 23429285 20448643 12107169 17047155 9228018 12887920 29497034 12911633 14612908 23955153 33961781 20829884 26972597 21620750
RPS17 RPS20 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
HSPA4 STUB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPLP2 RPS15 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPLP2 RPS17 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GSK3B MAPT â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPS15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPLP2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPS17 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF4EBP1 RPTOR â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
FADD RIPK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NDUFS2 NDUFS8 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL34 RPS20 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL34 RPS15A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL34 RPS13 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL34 RPS15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL34 RPS3A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPL34 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS15A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS15A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS13 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS20 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS17 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS13 RPS17 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS17 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS13 RPS15 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL19 RPS20 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS13 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS15A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS13 RPS15A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS15A RPS3A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS15A RPS17 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS15A RPS20 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS13 RPS20 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS20 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS13 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ABL1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12560071 20841568
ABL1 CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 19901323 26944284 15689152 19690332 16497976 24975575 19413330 20841568 18083107 19534553 20068231 19700222 9038181 14757045 23348931 11113134 10896159 18691976 28646794 29063113 24600352 12372285 19369195 18794154 15212693
ABL1 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11279131 20841568
ABL1 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 28222786 22761618 21209200 29941042 21639795 20823226 23348931 29103051
ABL1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 24430869 15192046 33889303 16273093 16943190 14760089 29880877 15618223 33574089 8910327 12631709 25173817 25402006 20841568 33947961 34107301 34469737 19915609 32019812 2022651 34290403 33707748 15329413 7678409 9733788 8490966 28338646 3263271 15901825 2022652 10069801 7506413 24658140 8408058 34385595 31980649 1314835 7741752 18668345 28724430 12648464 25073158 26079946 34155348
ABL1 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20841568 17892306
BAG2 STUB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16169850 16207813 25036637
BAX EIF2S3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S3 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
HIF1A BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18366759 17558861 15706354 24349374
AKT1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26763134 14766748 15642728 17525161
GSK3B BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29379583 27762303 15525785 20976235 26287183 17911107 16709574
CUL1 CDC25A â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
GSK3B CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 27038604 20348946 29725502 22655267 19230643 17570479 18167338 18480045 28680535
DVL2 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
DVL1 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 DVL3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 HSPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10772927 12558502
CSNK2A2 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 11146653 12588975 18212344 9806882
HSPA1A DNAJA1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 20084477 20809635 24012426 7828728 20072699
DNAJB6 HSPA1A â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 10954706 1754405 1586970 9920933 15802566 12974469 12853476
MAPK3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 1651322 17081983 3138233 15901825 16785992 1939237 91332050 27531070 17570479 2543683 2115882 34086370 17192257 1651323 15302935
RIPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11116146
SNX9 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16316319 24658140 25402006
EGFR ARF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12446727
EGFR HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20133936 31980649 22896792 20029029 24658140 21151618 25402006 23084749
EGFR LRRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24947832 22337768
HERC2 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
IQGAP1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11319218 8226933 1330321 16135787 17563371 7992057 8248196
IQGAP1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 31980649 28007913 8798539 19079338 9199170 8670801 8702968 15695813 15217908 8756646 18809683
IQGAP1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 17145710 9182573 8798539 12377780 9199170 8670801 17563371 8702968 12745076 15695813 21876773 8756646 12900413 18809683
RIPK1 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TRADD MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
MAPK3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21757713 21071439 19339977 19864431
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 25241761 15616583 26769850
MAPK3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MAPK3 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24342355 17290218 26036637 29233910 24484936 20937773
MAPK3 MKNK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 15547943 20080742 12040186 15173823 12697810 11940578 23331499 16227978 9155017 12738796 16039586 17255949 15187187 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
LRRK2 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22924508 24113872 26123245 24165324 25977830 22303461
PRKACA MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 9614189 9832145 19562805 12387894 9546672 19413330 1730702 7706316 9353289 20068231 16923168 21215781 8999860 9565682 11181841 10737616 7566346 12435421 17287340 9771888 19651622 9735171 11104762 12226093 16000144 8163474 26840030 6412713 9199504 10090741 11311121 2387894
CDK5 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 103.0 1.0 Omnipath 16697218 26944284 21945393 9614189 7592534 9832145 19562805 12387894 21848865 27641626 24268883 9546672 12071639 19413330 1330687 19415658 15302935 9353289 21671254 20508838 8282104 20068231 26998748 16568235 21215781 17045592 9565682 11181841 7566346 12435421 17287340 9771888 15843619 17078951 22761989 24367683 19651622 1181841 9735171 11104762 12226093 9199504 18510355 11311121 2387894 28785087
GSK3B MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 141.0 1.0 Omnipath 19616957 22278060 25641096 9832145 19562805 12387894 24268883 9546672 31640277 21865886 19413330 28386764 28379300 1330687 28734998 19415658 15302935 17047304 7706316 27349344 29408874 9716264 9353289 21671254 24165324 12714590 20068231 12387897 17570479 16452634 25815351 21215781 16568235 16519507 8999860 17045592 9565682 27857758 11181841 14690523 22690349 27073700 21443865 10601262 7566346 10737616 15522877 12435421 17287340 9771888 29725295 15073173 17078951 19651622 1181841 15542598 9735171 12226093 11104762 21985244 20049527 28835279 27965573 20679343 20308788 9199504 18510355 10090741 11311121 2387894
GSK3B NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23109003 10788511 17570479 11030334 9072970 15121840 15276472
PRKACA NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10788511 10611249 15121840 11030334
RAC1 RPTOR â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RAC1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
AKT1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
RPTOR HIF1A â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 12150925 12777372 15755954 15854902 16469695 16915281 17991864 19299511 19864431 19942859 20484410 22025673 22841746 23087689 26159692
RPTOR SQSTM1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 12150925 12777372 15340068 15755954 15854902 16252010 16469695 17991864 19299511 19864431 19942859 20484410 20531300 21981924 22025673 23087689 25002027 26159692 26587781 28574505
RAC1 RPTOR â—¼   DOWN_REGULATES ✅ - 40.0 1.0 ACSN 10702316 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19225151 19244117 19446321 19568798 19706736 19864431 20138985 20547845 20805416 21157483 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
EIF4EBP1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 18337751 24403073 16824195 12665511 12747827 12604610 18606717 19272448 16837165 12150926 18955708 21071439 16798736 22493283 17502379 15066126 18722121 12912989 15767663
AKT1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 18000759 21157483 11756412 11923280 16697215 20398329 17461779 18372248 15808505 20138985 20214616 19568798 15169778 19720745 17517883 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
AKT1 SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
SFN YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
SQSTM1 FADD â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26416459 10356400 19850933
ACTB RHOA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
PFN1 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17541406 8413665 563468 10600384 10411937 10592173 19000816 16189514 19338310 9463375
RAC1 ACTG1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 18391171 16262445 11231582 9600938 15040784 12743368
RHOA ACTG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
CASP8 FADD â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RIPK1 FADD â—¼   PHYSICAL_INTERACTION 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
FADD CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD TRADD â—¼   PHYSICAL_INTERACTION 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RIPK1 FADD â—¼   SHARES_COMPLEX 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
FADD CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD TRADD â—¼   SHARES_COMPLEX 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
MAP2K7 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11034606 10640736 16061179 15001534
TRADD FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 8565075 14744432 12911633 21760970 9430228 21724995 21741934 12796506 10911999 20203691 23955153 32296183 12107169 11112409 11464215 8681376 12887920 24686082 21183682 18545270
FADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 82.0 1.0 Omnipath 22864571 17145710 11717445 19524512 34591612 15280356 17047155 27552911 12911633 25043603 21458669 11788820 19176810 21525013 21988832 22179575 25939870 12702723 21737330 21741934 26437781 25911380 9228018 21785459 20829884 23972990 21620750 12220669 9774341 17159907 10521396 27321185 17290218 27560715 20103630 24098568 20203691 14612908 8681377 18485876 12107169 15659383 22421964 20448643 9343261 20125124 8681376 12887920 19060883 21737329 23142077 22173242 26972597 22274400 19935698 16410793
FADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 16585540 22864571 26733177 11002422 11854271 19524512 21458669 21525013 21052097 26865630 21741934 23972990 21620750 26186194 27560715 24098568 20203691 16227629 32296183 18485876 32024820 22890322 11464215 21737329 12887920 21183682 19524513 26972597 19373245 22848449 24577083
CDC42 TUBGCP2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10934474 11248548 11340065 15001467 15003621 15020669 15169870 15882626 16329184 17517963 17785506 18719708 19741094 21178402 22126964 22821962 27248291 7761442 9831565
MYH9 ACTR3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12194823 16606694 19349987 21840487 24857661 25712372
MYH9 WIPF1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10467124 10511705 11395419 11520460 12177428 14707117 15001467 16293614 16606694 17890224 19349987 19741094 21178402 21840487 22166994 23212475 23725295 24857661 25712372 8625410
MYH9 WIPF1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10467124 10511705 11395419 11520460 12177428 14707117 15001467 16293614 16606694 17890224 19349987 19741094 21178402 21840487 22166994 23212475 23725295 24857661 25712372 8625410
RIPK1 TRADD â—¼   PHYSICAL_INTERACTION 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
RIPK1 TRADD â—¼   SHARES_COMPLEX 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
ITCH RIPK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 19131965 20068034 21107885 21383157
RIPK1 TRADD â—¼   ENZYMATIC_REACTION ✅ 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
RIPK1 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TRADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12887920 24735611 20203691 21724995 8612133 21741934 16603398 21119000
CASP8 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 11002422 34389694 19524512 8657102 17047155 10469655 21458669 21419663 21525013 12842894 18570872 21741934 10521396 11002417 12884866 20203691 22421964 11042193 20125124 12887920 12215447 19935698
RIPK1 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
RIPK1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
DVL1 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15608632 19365405 12533515 17363564
DVL1 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 20006983 19625296
UBE2M CUL1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
UBE2M CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24949976 10713156 17914462 21247897 18805092 21946088 19245792 18826954
NDUFS8 NDUFS2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFS8 NDUFS2 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFS8 NDUFS2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
TRADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 15173123 20125124 12887920 10521396 20203691 21741934 14585074 17047155 22421964 19935698 11788820
TRADD MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TRADD MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TRADD MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
TRADD MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
RAC1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RAC1 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
DVL2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15262978 12533515
ARHGEF7 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 24792722 16983070 18684957 16492808 9659915 10592173 14557270 11309380
RAC1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353
RAC1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19568798 15169778 19720745 18925875 10949026 11715018 19143635 12393431 18636226 10617634 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
AKT1 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
YWHAB YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17085597 12657644 12426317 15071501
PRKACA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12654918 21572420 20591975 8599934 16109481 34088899 11162591 15890975
LRRK2 CSE1L â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 CSE1L â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 CSE1L â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
DVL2 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20006983 19625296
LRRK2 SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20127702 22924508 22658533 24907399 19576176
LRRK2 RAB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 29562525 26824392 29308544 29127255 28860483
LRRK2 RAB8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 30209220 32227113 32017888 26824392 29357897 29308544 29482628
LRRK2 SNAPIN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 23949442
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
LRRK2 ARHGEF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21048939
LRRK2 PRDX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21850687 24459295
DVL2 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 PFN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18798527 19523939 17373907 17021034
LRP6 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GSK3B LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22357953 23331499 19107203 21606194 16890161 21709260 16340998 16365045 19366350 21406690 16341017 17318175
ELOC HIF1A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
HIF1A HK2 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A LDHA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15794924 19828020 8089148 9632793 9746763 8955077 9748288 16319523
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
HIF1A HSPA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15794924 14726529 20068160 18844219 18683594
WIPF1 CDC42 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11340081 11829459 10878810 12213210 11553796 10781580 11157975
CDC42 CDC42EP3 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10753747 10934474 11248548 11340065 11747822 15001467 15003621 15020669 15169870 15882626 16329184 17517963 17785506 18037882 18719708 19741094 21178402 22126964 22821962 27248291 7761442 9831565
ARHGEF7 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15649357 16983070 9659915 25150978
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
PRKACA IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17360977 12624099
PTK6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20606012 15994200 15539407
PPP2R2A AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 18588945 16680151 20360384 16406523
PPP1CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
AKT1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12740362 11042204 19593530 22983196 17510053 23397142
AKT1 HK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 29985480 31435020
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 11691836 18767875 12665511 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
AKT1 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 11756412 9705322 11923280 16697215 20398329 18372248 12865427 15071501 15808505 20138985 20214616 15883165 15169778 10949026 12861023 11715018 18636226 9812896 17680028 11956222 10722653 20832730 18570873 16376338 17052453
AKT1 YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 YWHAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
CDK5 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12202491 9122166 17202132
CDK5 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19399218 24486837 17327227 19050041 29899409
CDK5 DNM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19651622 21765832 18088087 27725702 12855954 15302935
CDK5 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18833287 15178331 15917097 11877420 17085446 16554819 21947912 8131745 11517218 17459339 14970211 10341243 16705182 24610780 22112898 8764598 14557249 16223726 19455415 19090995 10936190 11146006 15944381
CDK5 CRMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18003833 22279220 16611631
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
USO1 GOLGA2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10903204 11306556 23378591 9150144 10679020 11285137 23698585 11927603 16624868
USO1 COPG2 â—¼   PHYSICAL_INTERACTION 18.0 1.0 Reactome 1680566 16926190 22013193 8505331 10318838 17451557 1631136 17360540 9751720 18283113 21844168 8132710 9114004 10921873 1957170 1898986 22304919 16940185
ARF4 COPG2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 Reactome 1680566 16926190 22013193 8505331 10318838 17451557 1631136 17360540 9751720 21844168 8132710 9114004 10921873 1957170 1898986 22304919 16940185
PRKACA ETV5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11682477
PRKACA SNAPIN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15269257 21356520 11283605
PRKACA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16543730 15845746 18691976 19836308 8524413 12054501 16039586 12147701 16522636 11035810 18669648
PRKACA YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 29109150 11956222 12861023 16376338 19451227
SNX9 DNM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18353773 16137687 15703209
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23584478 17570479 27387559 18701453
USO1 ARF4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22013193 20357002 11726511 17429068 25436559 18524849 16030262 16633337
PRKN SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11588587 18195004 20418918 12666095
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
BAG1 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9305631 11101523 19229298 11231577 11741305
HSPA1A HSPH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8721986 18550409 9873016 7585962 9305631
MAPK8IP2 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10756100 10490659 9733513
YWHAZ YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501