Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HIF1A MTA1 â—¼   COLOCALIZATION 2.0 0.8 intact 5218395 16511565
SP1 IRF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22307793 22464952
EGFR BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
PXN GAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6169422 14665621
GNAI1 GNG2 â—¼   PROXIMITY 2.0 0.8 intact 8189321 21552208
HTT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
AKT1 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15539407 20606012
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
ERBB3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17308105
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
CCND1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16461912 0506281103
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
HSP90AB1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21730179 1105160108
AR HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 21125667
AR ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21741601 20587519
AR SIN3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16254079
AR KHDRBS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18273831 20610535
DDX5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18829551
AR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15542423
PTK6 ARHGAP35 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 18829532 9819392
HSPA5 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TUBA4A BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HTT CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CBL PTK6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23352614 25019382
CBL MET â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5215187 11894096
CBL ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
LRRK2 CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
CBLB MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CCND1 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25733683 18719096
STAT3 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11279133
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
CCND1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11279133
CCT2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT3 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24756126 1001844
MYC CCT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
CCT5 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT8 CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CCT8 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDK4 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25733683 18719096
STAT3 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22218594
CDKN1B PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25733683 18719096
MYC CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24704206 26701207
KHDRBS1 DDX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
MYC DDX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
HSP90AA1 DNAJA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
HSP90AB1 DNAJA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22011577 21700222
HSP90AA1 DNAJA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
DNAJA2 HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22011577 21700222
SRMS DOK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 8433682 23822091
EREG EGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
MYC EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18365874 11509655
EGF MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20178463 17081983
STAT3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731598 14966128
EGFR NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
HBEGF EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19631971 20430953
EGFR PTPN1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 9355745 6671413
STAT3 EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23991099
STAT3 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PTK6 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0805009105 18719096
ERBB3 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
NRG1 ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10768865 23365119
ERBB4 STAT5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
ERBB4 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043
HTT EXOC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPD1 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GNB1 GNAI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7102203 16782902
TUBA4A GNAI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
GNB1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HSP90AB1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
STAT5B HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19014541 22552610
MYC HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
HSPA5 REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA6 REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA8 REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA9 REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC HSPA9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
MYC HSPD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10737792
HTT TCP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KHDRBS1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PTPN1 MET â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18579758 6731904
PTPN1 MET â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6764906 16537444
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
SOCS3 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16568091 22547065
STAT3 PTPN1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 15821101 6673264
TUBB REL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SP1 SLC25A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18706393
CCT2 CCT4 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
HIF1A HSP90AB1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
HSP90AB1 LRRK2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
KIT CBL â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 25737303 16780420 15315962 8950973
POLR2A SNRNP200 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
CCT4 CCT6A â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
CCT2 TCP1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
HNRNPC HNRNPM â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
CBL EPS8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27629044 25814554
MTA1 SIN3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24981860 12920132
HS90A ERBB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 24189400
HS90A HSPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25277244 27187154
HS90A ERBB4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 24658140
HS90A PTK6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 31980649
PTK6 TCPD â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25852190 31980649
MYC TCPD â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
PTK6 HS90B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 31980649
FGFR1 HS90B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 31980649
ERBB3 HS90B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 24189400
MYC TCPG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
PTK6 TCPG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25852190 31980649
LRRK2 TCPG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
MYC TCPA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
PTK6 TCPA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25852190 31980649
MYC TCPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
PTK6 TCPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25852190 31980649
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
FGFR1 CDC37 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18022941 31980649
CDC37 DDX5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24189400 16611982
CDC37 ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
MYC CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
MYC DDX17 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
DDX17 SFPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34133714 26344197
EGFR DDX5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28065597 31980649
EGFR SGPL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24189400 23956138
SP1 EPAS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22402494 17024177
MET ERBB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21918175 25326665
LRRK2 GNAI2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20876399 31046837
LRRK2 HSPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24725412 29519959
DNAJA2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
KHDRBS1 SFPQ â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
DDX17 HNRNPM â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EGFR STAT5B â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 11751923
HS90A STAT3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12559950 16189514
TCPD TCPQ â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22939629 24981860 26344197
LRRK2 HS90B â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20642453 31046837 23075850 24947832 17400507
HS90B GNAI2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 16263121 25241761
KIT CBLB â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12177062 15315962
CDC37 DDX17 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25036637 24189400 16611982
NRG1 EGF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 7730382 28988771
MYC HSPB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MYC XPO1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29467282 17314511 26673895 32140074
ERBB4 NRG1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
DDX17 SFPQ â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
EGFR EPS8 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
GNAI1 RGS1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
SP1 STAT3 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
IRF3 HS90A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20628368 16394098
MYC HS90A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28914785 29467282 12644583
HS90A LRRK2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16321986 20642453 22612223 19536328 19826009 31046837 20949042 23075850 26355680 24947832 17400507 18367605 29519959
AR CCND1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MYC HIF1A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15071503 28205554 28628118
HIF1A STAT3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
HSP90AB1 HSPA8 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
ERBB3 NRG2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ERBB4 NRG2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CCT3 CCT5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
TUBA1B TUBB4B â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
CCT5 CCT7 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
EGFR AP2B1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24189400 24797263 23956138 7534311
ERBB4 ERBB3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7689552 10572067 25315821 20227043
STAT3 HIF1A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18985005 23604114 15735682 23991099
CCT5 CCT8 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
SFPQ SIN3A â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
TUBA4A TUBB â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
HNRNPM SFPQ â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
CCT2 CCT3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
KHDR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11585385 16713569
AKT1 SMAD2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24412244 16362038
MET CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6538879 18273061
MET CBL â—¼   UBIQUITINATION ✅ 0.86 0.86 mint 11894096 5215187
DDX17 PTK6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 32296183 31980649
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
GNAI1 GNAI2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
NRG1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 7514177
HSP90AB1 HSPD1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
HSPA9 HSPD1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CCT2 CCT7 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
AKT1 CDC37 â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
TCPG TCPQ â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24981860 26344197 22939629 28514442
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CCND1 XPO1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21654808 12529437
LRRK2 CDC37 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 16321986 20642453 22612223 23075850 26355680 18367605
DDX17 DDX5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR WASL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
EGFR STAT3 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 22693070
NRG2 ERBB3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15358134 9168115 9168114
NRG2 ERBB4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15358134 9168115 9168114
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CCT2 CCT8 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
GNAI2 GNG2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ERBB2 ERBB4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EGFR HBEGF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CDC37 LRRK2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
HNRNPC SFPQ â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
CCT6A TCP1 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
BCAR1 PTPN1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR HSPA8 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
KHDRBS1 KHDRBS3 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
GAB1 MET â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CDK4 HS90B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 23455922 26186194 28514442 22939624 32707033
CDC37 AKT1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31980649 24869908 22504172 12176997
PTK6 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16273093 8940083 22973453
EGFR HSPB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23397142 15657067 24189400
ERBB2 PTK6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20700126 18719096 22973453
PTK6 ERBB3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11114724 16273093 22973453
DNAJA2 HSPA8 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
DNAJA1 HSPA8 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
GNAI2 GNAI3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CDK4 HSP90AA1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
HSPA8 LRRK2 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
HIF1A MTA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16969516 16511565
KHDR1 PTK6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 10913193
HIF1A HS90B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18538669 19802386 20668552 26517842
HS90B ERBB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20650008 28369073 22939624 24189400
HS90B AKT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20650008 31980649 10995457
EGFR AKT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
CDKN1B CCND1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 34591612
EGFR CDC37 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 23956138 24189400 12471035
MYC CDK4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22094256 28205554 21988832 28628118
EGFR DOK1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
EREG EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28988771 9419975
EGFR STAP2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140 28986450
EGFR HSP90AB1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EGFR GAB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EGFR PTPN1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CCT6A CCT7 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
CCT6A CCT8 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
EPS8 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 11408594 31980649 12127568 25402006 7532293
MYC IRF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
EGFR HS90A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 23956138 20029029 12006493 25402006 16849543 16024644 24189400 12471035 32669362
HIF1A HS90A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15147973 19491109 24844779 24648344 20668552 16507982 14764593 33550096 17442277 9079689 16951198 23722539 20724477 17244529 18538669 16189514 21413014 17237281 26517842 25204544 14726529 15319539
ERBB2 HS90A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25036637 26804907 17239458 22315411 18655187 24658140 23995768 21503962 24189400 20558745 11071886 12006493 20159553 22939624 16144943 21812426
HS90A CDK4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11867521 23455922 26804907 22315411 33961781 28537252 8703009 26186194 24292678 28514442 22939624 32707033 16611982
EGFR HS90B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15657067 24658140 31980649 24189400 23956138 25402006 20029029 22939624 12471035
TCPA TCPQ â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16085932 22939629 26344197 30021884
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
AR CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 17522055 18687691
AR MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20610535 20946682 17283128
AR PTPN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22282656 20610535
EGFR BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17145710 17570479 15951569
EGFR CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23158001 24797263 25872741 31182136 10635327 26055326 14505571 15210722 32714745 23774213 19155296 11370743 19836242 8665853 19947936 18271526 25140053 15668240 22394513 17486068 33323455 32377695 22203672 17182860 12604776 14627991 15383614 23153581 15735736 28541302 16849543 17242169 20562913 32904620 9121472 15677445 7782294 16923119 17995934 19531499 15465819 31959764 32114396 23457600 29629558 18316398 23799367 24714105 31120930 12061819 16713569 7657591 33617900 10086340 19225046 33762435 23175185 16729043 28791635 16246327 28198003 15962011 22266821 15117950 27059931 10428778 12734385 8662998 25005938 27903975 16969069 26177020 8798643 10799548 9756944 15159412 19578043 15657067 18255265 23418353 25754235 22976291 17545148 12803489 18319245 19713535 7592693 30544639 15107835 11994282 17971399 16105874 15282549 20940296 23897813 9130710 18273061 18508924 17880946 20124286 12593795 16914641 20877636 10092522 25521828 11408594 22591401 9890970 20308550 22833562 21772844 33627783 11239464
MYC CCT5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
HIF1A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19342889 20138114 19940121
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23436906 10527633 27756321 21278786 18803307 17148612 22439932 25315821 10572067 24189400 23866081
PTPN1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 6671413 9355745
SOCS3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 25402006 12070153
STAT3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18367518 21590492 23504318
PTPN1 EGFR â—¼   PHOSPHORYLATION ✅ 0.9 0.9 mint 6671413 9355745
PTPN1 EGFR â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 6732094 9050838
EGFR PTPN1 â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 25796184
EREG ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16829981 22891299 32196115
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
STAT3 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18266962 12559950
MYC HSPA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
STAT3 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16527988 14715258
SP1 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22399227 20018729
MYC MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
SMAD2 MYC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28205554 11804592 28628118
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
STAT3 PTK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12540842 20929863 19393627
SP1 PTK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11997104
STAT5B SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10821852 16306356 10359822
STAT3 STAP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12540842 20929863 19393627
CCT3 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT2 CCT6A â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT4 CCT8 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CCT3 CCT4 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CDK4 HSP90AB1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ERBB2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
CBL MET â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
CCT5 CCT6A â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBA1B TUBB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
PXN BCAR1 â—¼   UP_REGULATES ✅ + 0.91 0.91 Signor 27447856
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
ERBB3 NRG1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
HSP90AA1 LRRK2 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
CCT4 TCP1 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
TRIP10 WASL â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CDK4 CDC37 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
CDKN1B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5219242 17053782
EGFR STAT3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CCT4 CCT7 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT7 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT8 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
HSP90AA1 HSPA8 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CCT3 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
TCPD TCPG â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 33961781 24981860 26344197 22939629 28514442 22863883
CCT3 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
CCT7 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
TUBA1B TUBB â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
MET GAB1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 9242692 10871282 10995442 10734310 10913131
AKT1 HS90A â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 10995457 31980649 12586360 21767636 15843522 22504172 25714412 16027165 12176997 29311840 19356729 16189514 32707033 29139175
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
CCT2 CCT5 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
CCT3 CCT7 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
CBLB EGFR â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
TCPA TCPD â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 26344197 22939629 16085932 22863883 30021884
TCPA TCPG â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 26344197 16085932 22939629 28514442 22863883
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
ERBB4 ERBB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 24557338 30898150 8816440 16767099 25315821 10572067 10839362 21203579
CDC37 HS90A â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21871133 25036637 33961781 27353360 22729780 26496610 19875381 12930845 9685350 15647277 16335536 25486457 24462205 22504172 22939624 22315411 12176997 20159553 24292678 24189400 21360678 26804907 15001580 11413142 21745565 14718169 16611982
CDC37 HS90B â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 28215707 25036637 33961781 26496610 11036079 22939624 23428871 27339980 24189400 25486457
EGFR EGF â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 25453753 30083275 21822280 12620237 19531499 25080504 12093292 22729867 23597562 18427122 26280537 18271526 10970856 15620700 11684674 21439278 8663535 28988771 2790960 10788520 10085134 16274239 25241761 17697999 9135143 12297050
EGFR EREG â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22806884 25898135 30523157 9130710 21278786 15812817 20227043 16843263 10572067 19411071 19060928 8665853 10799311 8816440 17426253 17148612 21075308 12896906 15504738 23680147 23688700 23866081 22733765 7592681 21203579 25326665 24557338 23436906 30898150 7538656 25241761 25315821 11173924
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
HS90A HS90B â—¼   PHYSICAL_INTERACTION 0.98 0.98 HIPPIE 31536960 25036637 33961781 26344197 26496610 20353823 19875381 22863883 21360678
CDC37 CDK4 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
GNAI1 GNG2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
EGF EGFR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDK4 CDKN1B â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CCND1 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
GNAI2 GNB1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
GNAI3 GNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CCT2 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT3 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT4 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A TCP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT8 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT4 CCT8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT5 CCT6A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT7 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT8 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCND1 CDK4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT4 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT7 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNAI1 GNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB1 GNG2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PTK6 EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28214294 27738316
EGFR EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 31980649 11408594 8404850 7532293 24658140 12127568 25402006
MTA1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
SMAD2 IRF3 â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 21042762 21614932 22331441 23390297 6357187 8871614 9389648 9670020
HSP90AA1 BTC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10209155 14967450 23382875 8144591 24440602 9528863
BTC ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 8570211 10209155 10214951 22232668 11254912 16829981
PXN BCAR1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
PXN BCAR1 â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 12473693 14749719 15094799 15308668 15688067 16000375 18287025 18829532 18835194 22043013 29021139 9819392
TRIP10 PXN â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10467124 10511705 10713100 11395419 11520460 12177428 14707117 15001467 15541654 16293614 16606694 17785506 19741094 21178402 23212475 8625410
PTK6 PXN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17081983 15572663 15592455 18676874 18083107 7537852 17389395 7493940 7615549 19534553 11774284 15107421 12408869 10823820 16254239 15817476 16094384 19304789 16212419 21423176 15951569
PXN BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11313252 9418872 11577104 9759889 8810278
GNB1 GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNG2 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
HSP90AA1 GAB1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
GAB1 CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
MET GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10978177 17389395 19901323 10753869 15574420 15212693 10913131 10734310 11896055 20068231 10995442 9890893 16497976 14685170 17016520 18669648 11779868
EGFR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 19901323 15231819 16497976 25402006 17389395 20068231 23066441 11432805 9658397 19509291 18669648 10978177 10753869 10734310 11896055 18271526 24658140 10648629 11779868 31980649 15212693 9890893 17016520
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
PTK6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20606012 15994200 15539407
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 PTPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17081983 18691976 11579209 16189514 10480872
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
AKT1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12740362 11042204 19593530 22983196 17510053 23397142
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
AR EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18511414 8580999 7522959 15590903 14662770 18692155 17374439 18212060 20610535
AR EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15305378 19318561 21613411 19258514 15650253 17242169 18692155 15288768 11556855 20610535
HSPB1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19767773 17974989
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
AR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18358509 12534934 22260327 15288768 18951974
PTK6 ARAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20554524
PTK6 ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17389395 25136583 19534553 18829532 19690332 9819392 15592455 18083107
PTK6 ARHGAP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18829532 10713673
BCAR1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
BCAR1 CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
FGFR1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11019781 12601080
PTK6 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15870699 25938342 22084245
PTPN1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 9418872 15588985 9407132 8615784 8940134 15866871 12023880 16644720 10889023
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
EGF CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CBL CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CBL MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16397241 15123609 23331499 25241761 21222362 11894096 18672314 21163258 19450681 18273061 35309168 17533376 19433454 17635922 10514377
CBL KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9092574 17904548 25737303 8950973 15315962 17635922 10514377
CBLB KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15315962 12177062 17635922 10514377
CBLB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 19531499 11375397 10086340 12577067 10542134 17635922 10514377
STAT5B CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16155412 18550772 14645506 23504816
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
STAT3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16510571 19880237 17997399 15469392 16651438 21163886 22566696 16912181 22349830 16384639 12147685 21344490 20160059 19506034 20332458 23329648 11114718 17761947 22218594 15994929 21172343 18988190 18177723 24499623 21435102 19926637 18184402 17344214 22313388 23950841
HIF1A CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23455892 20360945 20179204 15991006
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
CDKN1B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 9106657 10908655 17254966 25416956 7478582
CTBP1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
TCF7 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
CCND1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 26203195 17145710 8978686 12036906 23562856 25416956 16985050 23707388 19767775 9837900 17517622 19237565 9372967 25502805 23718855 9228064 7736585 15232106 11360184 20837141 21306487 25910212 25241761 27107012 9150368 18537972 9178893 31217276 8867812 10580009 23007395 11160398 19470470 19075005 9106657 8259215 10908655 8756624 23543736 24855949 7568034 24218572 8662825 31515488 17205132
NRG1 CDC37 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
ERBB4 CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
EREG CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
NRG2 CDC37 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
CDC37 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
CDC37 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
MYC CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15208653 12835716 24951594 21384303 14519204 22395148 10688915 17728244 11983916 18414489
CDKN1B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 23602568 8978686 23707388 21439954 18850315 16326706 9658399 14597415 18615582 10198259 16782892 9632134 16189514 17053782 11360184 9311993 17092340 20837141 26186194 25241761 15695403 9464540 19470470 9106657 10908655 23543736 11940657 18285702
MYC CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21988832 11602341 17093053 22094256
CDKN1B UHMK1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 15314172 12904306 9264403 9448290 26279144 11889117 10831586 9199319 12093740 11726503 12814430 8635462
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
UHMK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 14504289 12782393 12482975 12042314 19887899 12093740 22293298 18384876 10831586 26528715 21045138 30393128 18636226 20811053 15735731 15302935
HSPA8 DNAJA1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 20084477 20809635 24012426 7828728 20072699
KIT DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11071635 11825908
EGF EGFR â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
EGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 131.0 1.0 Omnipath 17145710 17081983 21822280 20813200 23613900 9135143 25453753 21303971 10209155 26821125 12297050 27387652 25241761 30083275 12093292 30197274 21649524 19531499 18762250 16729043 26921391 17697999 17575160 21722395 12620237 19129184 10788520 23331499 3494473 15620700 14568001 15958209 24096486 18253097 16843263 18320059 21532939 10085134 22260327 15708576 26280537 23912460 21858221 11116185 10970856 27462018 18427122 25080504 20953304 19135477 11684674 8639530 27564112 18270696 2790960 17971399 23185569 19895983 28988771 29617357 23597562 19531623 23950932 21071413 8663535 6289330 16274239 17563729 21439278 20458382 22216880 18271526 12771140 21311755 24709886 25366117 12648462 21107857
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
EREG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9419975 36202915 20513444 28988771 8626392
HBEGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22529914 12097488 23331499 28943431 30071291 10209155 9135143 23888518 14967450 28988771 29274275 19531065 12621152 12725245
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23956138 12070153 20145033 14967450 20032199 21573184 25402006 10358079 23894143 14966128 24135280 25241761 14963038 24189400 15657067 24658140 15485908 15950906 18258752 31980649 9756944 22693070 12873986 15951569 15284024
EGFR STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10830280 10358079 12411494 10558875 16729043 17016520 11751923
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR PTPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 25796184 31980649 8621392 12573287 18253097 11106648 11506178 24658140 7540771 9050838 9355745 15982634 25402006 10889023 7693694 8999839
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
NRG1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12082616 8651595 10768865 12471041 12374700
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
NRG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9275162 1350381 19293191 14737100 7514177
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
ERBB2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 10839362 8816440 24557338 16767099 21203579 10572067
HSP90AA1 ERBB3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
NRG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10970856 16843264 7514177 7592681 23331499 8702572 7477375 11555649 9565587 16189514 26148232 9168115 9275162 10214951 17697999
NRG2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 9168114 7514177 9168115
NRG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 9275162 7721889 25052836 10970856 10214951 8062828 9565587 14967450 10537356 9168115
NRG2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 9168114 7477375 14967450 9168115
EREG ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9419975 16829981 22891299
HBEGF ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 1840698 23331499 10209155 9135143 12621152
NRG4 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 7477375 10348342 14967450 18988627
EREG HSP90AA1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HSP90AA1 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
STAT3 HIF1A â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10347215 10973499 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 18985005 19380816 20093776 20237412 20406969 20581311 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19265129 18644974 16007214 20924113 17597020 23991099
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
HIF1A MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16099863 17028975
STAT3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15735682 18985005 10973499
NRG2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
HSP90AA1 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HSP90AA1 NRG1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
SP1 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9328340 8923463
HSPB1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19656944
MYC HSPD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19022255 12695333 14519204 21995449 11983916 11085504
PTK6 KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10913193 19304789 16179349
KIT STAT3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
SP1 KIT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24008320 20833840 9834219
KIT STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10358045
SP1 MAT2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11124935 11476892 11427482
SP1 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11910354 12473536 9223667 15067326 21831840 17283128
PTPN1 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18579758 16537444 22789536 18819921
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
TCF7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
PTK6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18083107 17389395 21741923 19534553 7701321 19304789 16568091 15592455 12763138 15951569 20929863 18234692
PTK6 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17997837 21205088
PTK6 STAP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10980601 23331499 19393627 12540842 21071413
PTPN1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15821101 23331499 11970898
PTPN1 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10993888 12237455
SMAD2 SP1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
SMAD2 SP1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
SMAD2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19558215 10878024 12631740 11013220 11114293
STAT3 SOCS3 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18489773 22179221 15184887 21994466 20032196 12565872 11682619 23782265 22943202 19628067 23335796 12639901 18571793 23104276 16293640 23027374 22739025 21098664 11788008 18237746 19535626 23303450 20357037 16783372 22575502 16709613 14688368 19332118 23439558 10359822 19910459 19759305 11159537 16300827 16718380
STAT3 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737