Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
EGFR BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
S100A4 BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19740107 7256480
ERBB4 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
CRKL ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERG28 HSPE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ADAM17 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0509719103 16641105
ADAM17 MUC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12441351
ANKS1A ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR ANKS1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
FYN APH1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NCSTN APH1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
APH1A APH1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16252010 16630834
APH1A TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APH1B PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12522139 12471034
APH1B TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
BAK1 PSEN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ERBB4 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18676864
ERBB4 BYSL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17360433 0611516104
ERBB4 CBFA2T3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16815842
SYK CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
CBL PTK6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23352614 25019382
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
SRC CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17094785 7033811
NCK2 CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GRB2 CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 CBLB â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CBLB PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
ITCH CBLC â—¼   COLOCALIZATION 2.0 0.8 intact 12226085 5215735
CBLC ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLC ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
STAT5A CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16670309 23313770
CD9 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2862151 22069710
PSEN1 CDC37 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
CRK CDH11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
PSEN1 CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
ERBB3 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
DLG4 DLG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
ERBB4 DLG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212340 10725395
NTRK2 DLG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001478 23424281
DLG4 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
HRAS DUSP10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
S100A4 EGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19740107 7256480
EREG EGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
HRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
KRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGF PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 19531499
EGF SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 17673906
EGF SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 17673906
MUC1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11483589 5214341
EGFR NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
HBEGF EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19631971 20430953
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
TP53 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
NRG3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9772300 23331499
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 1845983
EPGN ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16469638 16829981
PTK6 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0805009105 18719096
ERBB2 SHC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 NCK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
HRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ERBB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11173924 16713569
ERBB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 8026468
GRB2 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
RASA1 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SRC ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB3 NCK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB3 NCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
TFAP2A ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18358466 11278550
TFAP2C ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11859873 11278550
NRG1 ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10768865 23365119
ERBB3 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB3 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
TROAP ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17360433 0611516104
STAT5A ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18653779 15534001
NCK2 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
RASA1 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PIK3R2 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
HSPE1 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ERBB4 SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB4 TROAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17360433 0611516104
ERBB4 STAT5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
ERBB4 SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 16829981
ERBB4 ZNF652 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16815842
ERBB4 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB4 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB4 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912174
ERBB4 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043
ERBB4 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ESR1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673088 7539106
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TXN ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19737086
SHC1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
HDAC6 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
NCK2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 11557983
FYN PSENEN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN RTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
FYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
FYN GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN NCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
TXN GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PTPRT GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21725282 8223591
PLCG2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3CA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PTPN6 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10660620 6671678
GRB2 TFAP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7518560 7527043
GRB2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
SOS1 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7518560 7527043
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
PTPN11 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HRAS PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069260 21779497
HRAS SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
TXN HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 TAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
STAT5B HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19014541 22552610
HSP90AB1 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PTPN11 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
S100A4 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20591429
STAT5A MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11084045
STAT5B MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11084045
TP53 MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697347 17308127
NCK1 PIK3CD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NCK2 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 11557983
PSENEN NCSTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
NCSTN PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10993067
PTPN11 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PIK3CA NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17652160 19411071
NRG2 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17652160 19411071
PIK3CD PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
SHC1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7537361
SYK PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9720763 10592173
PIK3CD PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CB SYK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
PIK3R2 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638 11733063
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
PIK3R1 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 9651378
PIK3R3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32606738
RASA1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
PLCG1 PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
RASA1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9020117 9743338
PSEN2 PSEN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19012753 18996842
PTPN11 SRC â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
PTPN6 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12220225
PTPN6 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8541543
PTPRH SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15850787
RASA1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8155326
SRC RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10592173 23027962
SRC RTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SOS1 SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9544989 6547749
TFAP2A SNAP91 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14532018
SOS1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SYK STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10825200
TP53 TFAP2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18980971 16636674
TP53 TXN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16096367
XPO1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17268548 17891139
CBLB PIK3R1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
NCK1 NCK2 â—¼   PHYSICAL_INTERACTION 802.0 0.8 STRING 36370105
CRK GRB2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
ERBB2 PIK3R2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
SYK PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 8657103
SHC1 GRB7 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 8940081 7907978
PIK3R1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16273093 5218056
PTPN12 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 28065597
PLCG2 ERBB2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 22973453 16273093 25241761
WWOX ERBB4 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24550385 16061658 22584572 20943952 19047365
PTPN12 SHC1 â—¼   PROXIMITY ✅ 0.81 0.81 mint 27880917
ITCH TRAF6 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
ERBB4 STAT5A â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
SRC PTN11 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 8959326 14687660 20308328
COF1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31980649 24658140
ESR1 COF1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25640309 19805454
HS90A ERBB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 24189400
HS90A ERBB4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 24658140
HS90A PTK6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939624 31980649
ALDOA EGFR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31980649 20029029
CDC37 ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
PTPN11 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16729043 5218694
EGFR PIN4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31980649 20029029
ERBB2 LRIG3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20126551 23723069
ERBB3 PPM1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28065597 31980649
SHC1 PIK3R1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16219545 5217992
PIK3CG PIK3R5 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
NCK1 SOS1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EGFR STAT5B â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 11751923
SHC3 GRB2 â—¼   RELOCALIZATION ✅ + 0.82 0.82 Signor 16829981
SOS1 KRAS â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 25624485
P85B SHC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 8662998 19380743
EGFR COF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31980649 24658140 20029029
HDAC6 HS90A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15937340 19158084 18591380 17851643 23703321 15916966 22367781
NCK2 CBL â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24287595
CBL ITCH â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
CBLB PLCG2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 16189514 12093870
NRG1 EGF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 7730382 28988771
ERBB3 MUC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11278868 12939402
ERBB4 MUC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11278868 12939402
MTMR9 MTMR2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 27880917 25659891
SOS1 MUC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 7664271 11278868
SHC1 PLCG2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12135708 10623845
PPM1A PPM1B â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ERBB4 NRG1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
GABRA1 GABRB2 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PSEN1 TRAF6 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PTN11 FYN â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11157475 16189514 16713569 10212213
PTN11 CBL â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18519587 17330819 11157475
SHC1 STA5A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 23397142 10996427
CBL STA5A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25814554 12193575 33767425 23533197
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
CBLB SHC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9614102 16189514
CBLB NCK1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25218436 16189514 16503409
EGFR CD44 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 23265944 12093135 16565089 15597342 11606076
ERBB4 DLG3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10725395 12175853
DLG4 FYN â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9892651 12419528 16713569
MUC4 ERBB2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12434309 18381409 11598901 11687512 25315821
RASA1 GRB2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12441060 16189514 16713569
NCK2 SOS1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10026169 16713569
NCSTN PSEN2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
EGFR PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 1689310
PTPN11 ERBB2 â—¼   DEPHOSPHORYLATION ✅ - 0.84 0.84 Signor 32024694
BAK1 TP53 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
ERBB4 PTPN11 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
ERBB3 NRG2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ERBB4 NRG2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
EGFR GAPDH â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ERBB2 LRIG1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
EGFR SHC4 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MTMR9 MTMR6 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 27880917
MTMR6 MTMR9 â—¼   PROXIMITY ✅ 0.85 0.85 mint 27880917
MDM2 HS90A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24147044 15001356 20540933 24583282 15001357
TROP ERBB4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21191175 17360433
CBLC ITCH â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12226085
CRK NCK1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9837978 8879209
PLCG1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 9020117 6805619
RASA1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24412244 16273093 22973453
ERBB2 MUC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 11278868 12939402
ERBB4 ERBB3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7689552 10572067 25315821 20227043
SRC GRB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12624098 9016807 16713569 16189514 11964172
SRC PLCG1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8657103 7510703 7682059 1689310 16713569 8885868
PLCG1 RASA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9743338 9020117 8977179
PLCG1 SHC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8662733 10652211 8155326
TP53 S100A4 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 19740107 7256480
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
TP53 XPO1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
NEDD4 SMURF2 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
P85B CRKL â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11553620 9092574
ERBB4 P85B â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22973453 16729043
TAB2 HS90A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 14743216 19875381
TAB1 HS90A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 14743216 19875381
HS90A FYN â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33961781 31980649 32814053 16888650 28514442 22939624 32707033
CD44 CD9 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 9117348 26686862
ERBB4 CRK â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22973453 16729043
HDAC6 ERBB2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
ERBB3 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
LRIG1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15282549 20126551 15345710
ERBB4 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
TRAF6 SRC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22447928 10635328 16189514 29545793
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
NRG1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 7514177
DLG1 DLG2 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CBLC FYN â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
PTPN11 EGFR â—¼   DEPHOSPHORYLATION ✅ - 0.86 0.86 Signor 12582165
CRKL PTN11 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9344843 9660791 23397142
CRK CBLB â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 25814554 19380743
CBLB NCK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 26871637 26186194 21516116 16713569 25416956 16189514
HBEGF CD44 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 7532176
DLG1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24550280 12175853
NEDD4 EGFR â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19953087 33762435 29455656
EGFR NTRK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
MATK ERBB2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12122014 16273093 9461599
NRG2 ERBB3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15358134 9168115 9168114
NRG2 ERBB4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15358134 9168115 9168114
FYN PLCG2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12181444 8395016 15144186 7682059 16713569 16189514
LRIG1 LRIG3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 23723069
NCK2 NTRK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12074588 16713569
PTPN6 SYK â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
S100A4 TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EGFR MUC1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ERBB2 ERBB4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EGFR HBEGF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EGFR USP8 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RHOA SMURF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
TP53 IRF2BP2 â—¼   KO_DOWN_REGULATES ✅ - -0.88 0.87 PKG 28854368
CRK SRC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ERBB2 GRB7 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ERBB4 YAP1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PIK3R1 SHC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CRKL PIK3R1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CBLB CRKL â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25814554 10022120
P85B FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 1334406 16713569
ERBB4 PTN11 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 22973453 16729043 28065597
PTN11 SOS1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9344843 9632781 20473329 16371368
STA5A ERBB4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16729043 22584572 15534001
STA5A ESR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15304355 11682624
FYN CD44 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9573028 16189514 16713569
DLG4 ERBB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10839362 16713569
PTK6 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16273093 8940083 22973453
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
LRIG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15282549 20126551 23723069 15345710
ERBB2 PTK6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20700126 18719096 22973453
PTK6 ERBB3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11114724 16273093 22973453
ERBB3 RNF41 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
RNF41 ERBB4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 27648936 11867753
NTRK2 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16713569 9648856
SHC3 NTRK2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9507002 19166614 12074588
SRC RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11389730 16189514 16713569 1717825
MTMR6 MTMR9 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CRKL EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CRK EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EGFR STAT5A â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CBL NCK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CBL PLCG1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRK PIK3R1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EGFR NCK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EGFR NCK2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ERBB3 PIK3R2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EGFR PIK3R2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ERBB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CBL SHC1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL PIK3R2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RNF41 USP8 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 23750007
USP8 RNF41 â—¼   DEUBIQUITINATION ✅ + 0.88 0.88 Signor 23750007
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
PTPN12 SHC1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
EGFR CRKL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18271526 24658140 31980649 16729043 23397142 25754235 25402006
P85B GRB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20936779 8662998 19380743 21706016
P85B CRK â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25814554 19380743 31980649
HS90A ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18388150 23912458 17699868 9222609 15538384 21503962 22939624 20353944 16037132 19805454 27483141 23403292 11911945 12962497 9115298
HS90A SRC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16844778 22315411 31980649 28537252 1310678 32707033 16189514
CBLC CRK â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10362357 16713569 25814554 16189514 10571044
CD44 SRC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21701559 11084024 9519902
EGFR CDC37 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 23956138 24189400 12471035
LRIG1 EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15282549 16847455 15345710 20126551 18542056
SHC3 EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9507002 22973453 9685397 8610109 16273093 8662772
EREG EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28988771 9419975
EGFR TAB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18271526 31980649 25402006 24658140
EGFR HSP90AB1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
ERBB4 ITCH â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18334649 17463226
MDM2 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12897156 17545634 10766163 11178989 16713569 31012223
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
MUC1 GRB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20936779 7664271
NCK2 NCK1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 26186194 31980649
NCOR1 TAB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16469706 12150997
NTRK2 SHC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26253177 16034442 12419535 10092678 28213521
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
PTPN11 SOS1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
EGFR PIK3R1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
GABRA1 GABRB3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
EGFR RASA1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
TAB1 TAB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
GABRA1 GABRG2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ERBB4 GRB2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
GRB7 ERBB3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 24189400 9516479 16273093 16189514
GRB7 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9079677 12061724 7907978 22973453 12975581 16273093 17875712
DIAPH1 BTC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PIK3R1 BTC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
BTC RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
BTC PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
BTC PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
CRKL STA5A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9657743 9845531 9837784 11167825
ERBB3 P85B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16273093 16729043 22973453 24189400
P85B ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 16729043 16273093 1334406
EGFR P85B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19531499 31959764 24658140 31980649 22973453 23956138 11172806 1334406 25402006 16273093
ERBB2 PTN11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 16729043 28065597 9756944 8959326 16273093
PTN11 STA5A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10617656 12060651 16189514 12237455
PTN11 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12270932 11223155 20473329 16729043 22973453 7673163 28065597 24935154 9756944 14560030 7588774 8959326 16273093
STA5A EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 16729043 24135280 10358079 25402006 22729867
EGFR HS90A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 23956138 20029029 12006493 25402006 16849543 16024644 24189400 12471035 32669362
ERBB2 HS90A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25036637 26804907 17239458 22315411 18655187 24658140 23995768 21503962 24189400 20558745 11071886 12006493 20159553 22939624 16144943 21812426
ADAM17 HBEGF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16054021 26284334 18372913
APH1B PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12297508
APH1B NCSTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857757 12297508
TP53 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 15077116
SRC CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22203672 29899407 17141222 18996392 12941616 15135048 18273061 10829062 31120930 19861161 7782294 16713569 8635998 11994282 17094785 16636290
EGFR CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23158001 24797263 25872741 31182136 10635327 26055326 14505571 15210722 32714745 23774213 19155296 11370743 19836242 8665853 19947936 18271526 25140053 15668240 22394513 17486068 33323455 32377695 22203672 17182860 12604776 14627991 15383614 23153581 15735736 28541302 16849543 17242169 20562913 32904620 9121472 15677445 7782294 16923119 17995934 19531499 15465819 31959764 32114396 23457600 29629558 18316398 23799367 24714105 31120930 12061819 16713569 7657591 33617900 10086340 19225046 33762435 23175185 16729043 28791635 16246327 28198003 15962011 22266821 15117950 27059931 10428778 12734385 8662998 25005938 27903975 16969069 26177020 8798643 10799548 9756944 15159412 19578043 15657067 18255265 23418353 25754235 22976291 17545148 12803489 18319245 19713535 7592693 30544639 15107835 11994282 17971399 16105874 15282549 20940296 23897813 9130710 18273061 18508924 17880946 20124286 12593795 16914641 20877636 10092522 25521828 11408594 22591401 9890970 20308550 22833562 21772844 33627783 11239464
NCK1 CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 7517397 10829062 10372803 10204582 11494134 24287595 10967110 16503409 9851874
PTPN6 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11157475 12176909
LRIG1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15282549 23331499
CBL PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 17635922 10514377
CBLB PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11087752 17635922 10514377
CBLB NCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16503409 16189514
SHC1 CBLC â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 SRC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 32707033 31980649 11085988
HRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
NRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
TAB1 CFL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EGFR CRK â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10595738 9480911 9642287 24658140 31980649 11956190 16729043 22973453 8875975 25402006 9617486 16273093 12198159
NRG2 DIAPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PPM1F DIAPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8296461 18230650 013557
EREG DIAPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 EGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 NRG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
FYN DLG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 13129934
RHOA DLG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9870943 9870942 16202622
EGF RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGF PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8940074 1672440 10473558
STAT5A EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18996136 12697691 21617857
EGF PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
EGF PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17496910 1334406 19531499
EGF PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23613900 17081983 16525023
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23436906 10527633 27756321 21278786 18803307 17148612 22439932 25315821 10572067 24189400 23866081
PLCG2 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 22973453 25241761 25402006 16273093
NCK1 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 9362449 16273093 25402006 1333047 10026169 8662998
NCK2 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 22973453 9843575 16713569 25402006 1333047 10026169 9737977
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGFR PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 19704002 21075308 7542762 7797556 19372587 29720121 11940572 17875712
PLCG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 16273093 1683701 1676673
SHC1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30898150 10085134 9019162 24658140 22973453 16729043 9710588 28065597 16843263 9756944 16713569 16273093 8665853
ERBB2 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
ERBB2 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 17496910
ERBB2 SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 16729043
SHC1 ERBB3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11546794 9019162 24658140 22973453 16729043 24189400 9756944 9694850 16273093 16189514 8665853
ERBB3 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
ERBB3 PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
RNF41 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17384230 12411582 27353365
EREG ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16829981 22891299 32196115
LRIG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16123311
RHOA ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
YAP1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16061658 15023535 25283809 12807903 19047365
PIK3CA ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3R1 ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PTPN12 ERBB4 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
LRIG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16123311
ERBB4 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15985438
EREG PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
EREG PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
EREG RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EREG PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
NCOR1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16469706 17400812 12145334 16713569 12738788 21182203 24051437
SHC1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20935677 11773443 16713569
SRC ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17043237 17284441 17400812 15604093 11032808 17921256 18451880 15020686 12736255 11564893 23065768 10454579 20935677 17363140 16957778 14963108 11013076 29720121 15784253 24498420 17627277 12630920 22328528 14766010 24051437 7539106 27420286 15140878
TFAP2A ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10497269 19458056 9850080
STAT5B ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11731618 11682625
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
PIK3CD GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
SHC3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16729043 12242309 16829981
RASA1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12441060 16713569
PIK3R1 HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3CA HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
RHOA HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PTPN12 HBEGF â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
SRC KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30644389 26854235 9096340
SOS1 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25624485 23331499 16293107
TRIM28 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16107876
SRC MUC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21798038 11152665 11483589
NCK1 RASA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16189514 10508618 21664272 9233798
RTN4 NCK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 16752908 7102262 060091
RHOA NRG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
NRG1 PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
NRG2 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
NRG2 PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
PTPN12 NRG4 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
PIK3CA NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
RHOA NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PIK3R1 NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
NTRK2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8808684 12419535 16034442
TP53 PIAS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24584189 11877452
SHC1 PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
PTPN11 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10386953 7522233
SHC1 PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
PIK3CD SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3R1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8596638 14665640 11733063
PIK3R2 SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
SYK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15536084
SRC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
SRC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
PLCG1 SYK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 7517665 8657103 15161916
TXN PRDX5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 21385867 10514471 17519234
PTPN6 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12220225 9211920
STAT5B STAT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15043997 17997837 14532269
STAT5A STAT5B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21542777 15043997 17997837
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
EGFR SOS1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EGFR PLCG2 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
ERBB2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ERBB3 PIK3R1 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
PSEN2 PSENEN â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
SHC1 SOS1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PIK3R1 PTPN11 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
ERBB3 SHC1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
ERBB4 SHC1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ERBB3 NRG1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
ERBB3 PTN11 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 22973453 9756944 28065597
FYN CDC37 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 25036637 31980649 28514442 32707033
DLG1 DLG3 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 26496610 12351654
EGFR PLCG1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
EGFR SHC3 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
PIK3R1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
TAB2 TRAF6 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
ERBB2 SHC1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
DLG2 DLG4 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HIPPIE 21653829 9182804
EGFR EPGN â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PLCG1 SYK â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
ERBB2 PTPN11 â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
PIK3R1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5217342 15556646
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
EGFR PTPN11 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PIK3CA PIK3R3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
HRAS PIK3CG â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CBL SYK â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ERBB3 GRB2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
GRB2 PTPN11 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
DLG4 DLG3 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 10026200 28973854
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
SOS1 FYN â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 17474147 16713569 9856337
CBLC SRC â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CBLB EGFR â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CBLB GRB2 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
P85B CBL â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 19190244 11133830 15107835 25814554 19380743 7629144
SHC1 CBL â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 9234717 9541596 15677445 8621719 16713569 8950973 10025673 10570290 8662998 19380743 9461587 9434624
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
SOS1 EGFR â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 19531499 18271526 31959764 24797263 7510700 20473329 19289468 10675333 23956138 25754235 8621459 16713569 26005835 9447973
ERBB4 ERBB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 24557338 30898150 8816440 16767099 25315821 10572067 10839362 21203579
PLCG1 GRB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 21706016 7629168 10940929 16038803 9020117 16713569 9281317 7516467
PLCG1 NTRK2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 12419535 10092678 26253177 12074588
SOS1 PLCG1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 10913276 10940929 9020117 16713569 17474147
PSENEN PSEN1 â—¼   CLEAVAGE ✅ + 0.96 0.96 Signor 12522139
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PTN11 GRB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 8702859 33961781 12531430 34407391 10747947 9824671 12577067 9361008 9660791 19380743 7534299 8995399 16371368 10080542 21706016 20473329 7523381 8041791 9362449 10212213 8647120 28514442 16189514 9632781 31980649 9254654 8959326
CDC37 HS90A â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21871133 25036637 33961781 27353360 22729780 26496610 19875381 12930845 9685350 15647277 16335536 25486457 24462205 22504172 22939624 22315411 12176997 20159553 24292678 24189400 21360678 26804907 15001580 11413142 21745565 14718169 16611982
FYN CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9677430 8621719 12244174 7782294 10629042 119942 7642581 15556646 12231245 9311917 9535867 8626543 10799548 16713569 16503409 10092522 8900205 8995358 25814554 9890970 15190072 15208330 12941616 10829062 11239464 8662998 17094785
PLCG1 CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9234717 12941616 25241761 16467851 12061819 9712732 16713569 16503409 17372230 12803489
SOS1 CRK â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 8810325 33961781 8943292 31980649 25241761 32203420 19380743 17474147
EGFR EGF â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 25453753 30083275 21822280 12620237 19531499 25080504 12093292 22729867 23597562 18427122 26280537 18271526 10970856 15620700 11684674 21439278 8663535 28988771 2790960 10788520 10085134 16274239 25241761 17697999 9135143 12297050
SHC1 EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10595738 24797263 24658140 7542744 21278788 9130710 28065597 10766863 10635327 8034616 24430869 7518560 12577067 19531499 31959764 8810340 9742218 11196191 23799367 23956138 9756944 16713569 11370743 8665853 18271526 15657067 11408594 20473329 22973453 16729043 20935677 20067773 7506413 16273093 25754235 8610109 24189400 26551075 9388490 8887653 31980649 7542991 9544989 9020193 25187647 25402006 30544639 10049786 8662998
SRC EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22227249 17284441 24658140 17158602 21278788 20333651 28065597 7527393 7797556 10777553 16713569 20624308 23175185 7506422 22973453 20935677 24189400 11983694 10075741 31980649 19704002 10358079 10971656 21268077 9020193 25402006 21573184 8845374
EGFR EREG â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22806884 25898135 30523157 9130710 21278786 15812817 20227043 16843263 10572067 19411071 19060928 8665853 10799311 8816440 17426253 17148612 21075308 12896906 15504738 23680147 23688700 23866081 22733765 7592681 21203579 25326665 24557338 23436906 30898150 7538656 25241761 25315821 11173924
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
SRC SHC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9388490 18840094 9710204 10482988 9096689 7499252 8939605 26551075 16189514
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RNF41 USP8 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
CBLC EGFR â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PSEN1 PSENEN â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
APH1A PSEN1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGF EGFR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
APH1A PSENEN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
APH1A NCSTN â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PIK3CD PIK3R1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
NCSTN PSENEN â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
DLG4 GRIN1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
SHC1 GRB2 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 12213123 8491186 8950973 9927207 9733714 8112292 10356320 11370743 32062451 8294403 16371368 22057045 9045692 9032244 8995379 7514169 9175774 9541596 8663178 7629070 9019162 7597091 7798267 9544989 9488479 8940013 10570290 15812354 11792427 8621719 24430869 7650032 11453982 16713569 7516467 10477741 8662733 11302736 26551075 9254595 7559490 12441060 8662998 8235613 12485888 28690151 16520382 8939605 11505033 9129019 11707405 15888547 8647288 7524086 25416956 24189400 11827484 12149229 8195171 21725358 9020193 10049786 9797459 9886492 33961781 9126968 8626525 7537740 12577067 11964172 12898421 8810340 22974441 19380743 9434624 10080542 9083103 21706016 15688026 7535773 31980649 8561895 7744881
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
NCSTN PSEN1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRKL â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CBL CRK â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EGFR SHC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CBL PIK3R1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERBB3 GRB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 24189400 16273093 9516479 16189514
SHC1 BTC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
HSP90AA1 BTC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10209155 14967450 23382875 8144591 24440602 9528863
BTC ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 8570211 10209155 10214951 22232668 11254912 16829981
CRK CRKL â—¼   PHYSICAL_INTERACTION 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL CBL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRK CRKL â—¼   SHARES_COMPLEX 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL CBL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
FYN CRKL â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
CRK CRKL â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL CBL â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRKL PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
EGFR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 23397142 18271526 24658140 25402006 16729043
CRKL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9092574 16135792 11418612 23397142 9461587 16982329
CRKL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9092574 9461587 11553620
ADAM17 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15534001 15746097 10744726 9685416 26554003 17486069
NCSTN APH1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15189355 21071413 14572442 12471034 12857757 18201567 12297508
APH1A PSENEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12522139 15322109 12740439 16189514
APH1A PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12522139 12471034 16189514 12297508
APH1A PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12471034 16189514 12297508
TP53 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22983126 18519674 21233848 15033822 15489892 15105295 10741712
CBFA2T3 ZNF652 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 16966434 20116376
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
GRB2 CBL â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 25036637 25872741 8950973 917890 7642581 17944804 15210722 9108392 20936779 8695851 19836242 14725908 169092 28514442 9541596 9174058 11823423 12941616 10829062 10570290 7544353 11792427 8083187 15677445 8621719 9233773 9311917 23799367 16713569 10086340 9234717 8995358 25814554 9716598 11997436 7791764 8943292 8063801 8995445 8662998 11263968 16906159 8626404 9129019 98621719 17072306 9242692 10521482 9872323 8647120 7592693 9092538 10025673 17971399 17094785 9851874 11399323 33961781 9259313 18273061 7537740 8649804 9295052 11964172 9367879 20124286 10204582 19380743 9434624 21706016 8900205 9178909 12839496 9461587 31980649 11133830 33627783 8824292 8621483
PIK3CD CBL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
EGF CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CRK CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CBL CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CRK CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
SYK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 16289966 15922744 9525940 19419964 11133830 33512474 18273061 10829062 10799548 10540342 10934191 7721825 12435267 11331248 12604776 9890970 11042121 10092522 11997497 12522270 9857068 9988765 15556646 11742985 15536084 8621719 9102067 22880054 10551821 11239464 10617633 11994282 10570266 12881521 9535867 15577829
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
CRK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 8683103 16289966 8626543 8621483 9617486 16713569 9416834 8524328 10962563 8626404 9367879 8662998 12393469 11792427 15581361 9013636 15581362 9178909 9988765 18835194 8943292 20697350 9129019 19380743 25814554 9461587
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CBL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 9092574 19190244 11406619 11133830 7629144 17635922 11526404 8662998 8995358 8080844 15107835 23109003 17722974 8621719 16107703 9414268 10514377 15790353 19531499 22315502 19380743 25814554 9461587
CBL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7517397 9712732 12941616 25241761 12061819 23109003 9234717 16503409 11709089 16713569 17372230 16467851 12803489
CBL PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 8641358 9119889 19380743 8621719 7629144 17635922 10514377
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 98.0 1.0 Omnipath 9092574 19190244 16289966 11406619 7642581 11133830 10358153 8941725 9234717 8612729 11157475 10620516 16713569 21203488 11418612 24113870 17635922 18374639 14530346 11526404 8662998 8995358 11030146 9890970 9541596 11042121 15581361 9890943 8080844 7791764 9178909 15107835 8995243 8695807 9988765 23109003 11944898 15556646 17237826 10025673 17722974 8621719 16135792 16107703 16219545 9461587 9160881 9414268 16982329 19861161 10514377 9918857 11087752 9092538 11994282 9259313 15790353 19531499 9174058 8702998 25814554 22315502 19380743 10918571 8896416
CBLB CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 8626404 19380743 12697763 25814554
CBLB SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 12771181 16189514 27428901 10022120
CBLB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 19531499 11375397 10086340 12577067 10542134 17635922 10514377
CBLB SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19531499 11375397 16189514 9614102 12577067
CBLB PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11087752 21780115 10488096 19531499 11526404 15032589 23109003 22880054 17635922 10514377
CBLB FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15208330 16503409 32296183 25814554 8083187
CBLB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 10022120 25416956 21706016 31467278 32814053 9614102 17635922 11375397 8626404 16189514 21900206 20936779 27107012 12577067 10514377 19531499 10086340 29997244
CBLB PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 11087752 21780115 10488096 19531499 11526404 10086340 15032589 23109003 22880054 9614102 17635922 10514377
SRC CBLC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9988270 20525694 24425877 14661060 22888118
CBLC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10362357 22888118 17635922 10514377
TP53 CDC25C â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11396965 16582636 16807237 15574328 19861536 11972334
TP53 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18431400 29302370 16753148 16713569 10853038
NRG1 CDC37 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
ERBB4 CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
SHC1 CDC37 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
PLCG1 CDC37 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
EREG CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
NRG2 CDC37 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
CDC37 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
CDC37 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
SRC CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19802004
GRB2 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRK PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
PIK3R1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
EGFR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 52.0 1.0 Omnipath 10595738 9480991 16273093 9617486 25402006 17399949 8662907 8875975 21602891 20068231 8194526 12198159 9642287 11956190 24658140 26656091 9480911 31980649 15212693 26473374 16729043 17016520
CRK PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 25814554 35044719 19380743
CRK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
CRK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 35044719 19380743 25814554 11418612
RHOA DIAPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22820501 12773565 18218625 16109481 15864301
SRC DLG4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24981431 16990796 14529711 18721130
FYN DLG4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12419528 25720756 18721130 9892651 16713569 22709448
DLG4 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 10725395 16767099 17018285 10839362 12716924
DLG4 GRIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12068077 9009191 14732708 11937501 11506858 9502803 16767099 15030493
EGF EGFR â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
EGF RHOA â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
EGF GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17081983 19531499 17673906 10973965
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
EGF SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23349873 19481075 15845350 22927910 27462789
EGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 131.0 1.0 Omnipath 17145710 17081983 21822280 20813200 23613900 9135143 25453753 21303971 10209155 26821125 12297050 27387652 25241761 30083275 12093292 30197274 21649524 19531499 18762250 16729043 26921391 17697999 17575160 21722395 12620237 19129184 10788520 23331499 3494473 15620700 14568001 15958209 24096486 18253097 16843263 18320059 21532939 10085134 22260327 15708576 26280537 23912460 21858221 11116185 10970856 27462018 18427122 25080504 20953304 19135477 11684674 8639530 27564112 18270696 2790960 17971399 23185569 19895983 28988771 29617357 23597562 19531623 23950932 21071413 8663535 6289330 16274239 17563729 21439278 20458382 22216880 18271526 12771140 21311755 24709886 25366117 12648462 21107857
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
EGFR SHC1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
TFAP2A EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16449191 8621697 14522076
TP53 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20190820 18359760 9664135 10029407 8152794 11713584 8887630 9285564 19597475 11546792 1586628 18604200 18391986
EREG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9419975 36202915 20513444 28988771 8626392
HBEGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22529914 12097488 23331499 28943431 30071291 10209155 9135143 23888518 14967450 28988771 29274275 19531065 12621152 12725245
USP8 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16520378 16120644 25853104 20736164
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
PTPN11 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 28065597 9756944 7588774 16273093 14560030 9642214 8197172 15618223 12270932 7673163 12582165 10411909 16729043 11223155 12577067
EPGN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27298358 28988771 20513444
PTPN6 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 9038217 9287352 7673163 7518460 9733788
EGFR PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 25241761 16273093 24658140 17570479 25402006
EGFR SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 24212772 9507002 16273093 11791173 8760305 8662772
EGFR PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17496910 31980649 25241761 16273093 24658140 25402006
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9544989 19531499 9447973 16713569 12577067
EGFR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 78.0 1.0 Omnipath 9544989 8808684 10595738 23956138 9388490 11350724 16273093 7542991 7681824 7518560 9710588 23799367 16713569 25402006 11370743 24797263 9742218 20935677 8887653 8034616 23331499 8662998 7542744 10049786 28065597 9130710 10635327 24189400 7506413 18271526 15657067 24658140 8810340 12577067 11196191 10766863 23178716 31980649 35384245 11408594 19531499 9756944 26551075 1623525 15951569 16729043 17956904
EGFR RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8647858 16273093 7991458 1850098 17570479 1633149 1385407
EGFR STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10830280 10358079 12411494 10558875 16729043 17016520 11751923
EGFR MUC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11483589 11152665 31980649 17889671 21258405 24658140 14521915 25402006 16983337 15212693 11278868
EGFR NCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 1333047 23331499 10026169 9737977 24658140 16713569 25402006 9843575 1333046
EGFR STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 31980649 10358079 24658140 25402006 18586824 16729043
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17496910 31980649 23956138 19531499 16273093 24658140 11172806 1334406 25402006
EGFR LRIG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15282549 23331499 15345710 21071413 18542056
EGFR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19901323 17081983 16273093 9207933 2472219 16497976 15592455 16126727 16713569 24797263 17389395 8578591 23331499 7991458 1689310 20068231 17570479 9176240 12803489 16153436 7993895 16038803 7805859 15864276 1708307 7682059 15144186 11983899 12601080 9756944 15212693 14568990 12061819 9020117 8885868 12648464 8657103 15951569 17016520 7693694
EGFR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17496910 26918608 7797556 25241761 19531499 16273093 8662998 14967450 16713569 21701776
EGFR HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20133936 31980649 22896792 20029029 24658140 21151618 25402006 23084749
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR NCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 1333047 23331499 31980649 10026169 16273093 9362449 8662998 24658140 25402006 15951569 9843575
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
TFAP2A ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19906305 10645007 7846046 22577344 18177484 15870067 9850080 10698518 16108032 11485026 18218085 12942124
TFAP2C ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19906305 10645007 20629094 11485026 18218085
NRG1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12082616 8651595 10768865 12471041 12374700
LRIG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15282549 23331499 15345710 23723069 16123311
NRG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9275162 1350381 19293191 14737100 7514177
PTPN11 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9756944 16273093 16729043 32024694
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
ERBB2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 17496910 11546794 23331499 9756944 16273093 1351056 15680399 11331299 21075308 16843263
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
ERBB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 16273093 1676673 1683701
ERBB2 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16273093 25241761
ERBB2 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16273093 24412244
ERBB2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 28065597 23331499 9756944 16273093 8026468 9710588 10085134 24658140 9590694 16713569 16729043 16843263
ERBB2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 10839362 8816440 24557338 16767099 21203579 10572067
ERBB2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 16273093 1334406 16729043
HSP90AA1 ERBB3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
NRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10970856 16843264 7514177 7592681 23331499 8702572 7477375 11555649 9565587 16189514 26148232 9168115 9275162 10214951 17697999
NRG2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 9168114 7514177 9168115
ERBB3 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16273093 17496910 24189400
ERBB3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9694850 9756944 16273093 24189400 8026468 24658140 9590694 16189514 16729043
ERBB3 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 16273093 24189400 16729043
ERBB3 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 17145710 18803287 16273093 23331499 21278786 21071413 11694521 18988627 10383151 9130710 17496910 11546794 20227043 20007781 24189400 10572067 22439932 9756944 21075308
ERBB3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9756944 24189400 11173924 24658140 14967450 16729043
NRG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 9275162 7721889 25052836 10970856 10214951 8062828 9565587 14967450 10537356 9168115
NRG2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 9168114 7477375 14967450 9168115
EREG ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9419975 16829981 22891299
NRG3 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9275162 7477375 14967450 18988627
ITCH ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18334649 17463226
HBEGF ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 1840698 23331499 10209155 9135143 12621152
NRG4 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 7477375 10348342 14967450 18988627
ERBB4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24658140 16829981 16729043 12731860 25140053
ERBB4 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15534001 10508857 15863494 16729043
ERBB4 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16273093 16729043 24658140
ERBB4 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16729043 17496910
EREG HSP90AA1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
EREG SHC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
STAT5A ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11731618 22201800 11682624 11682625
TFAP2C ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24639548 24413532 19458056 10497269 17875680 11278455 20629094 7891714 9113991
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
PIK3CD FYN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
SYK FYN â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10358164 11907067 12524384 14568985 15536084 17101731 19909365 20150200015 21149606 21378271 21910624 23609447 8189062 8226994 9000133 9295024 9314552 9396765 9632805 9763615
FYN PTPN11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
NCK1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
NTRK2 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 16713569 9648856
FYN PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10212213 11157475 16713569
FYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7515100 1334406 16713569 1652056
FYN SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7797565 7513017 17570479 10477689 9535867 16713569
FYN PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19901323 8395016 12181444 11606584 14656219 7682059 15144186 11507089 16497976 16713569
FYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 16713569 9446569 17389395 23331499 18578522 10921922 10482988 10764799 18452278 20068231 10592173 18669648 12522270 9685404 10896916 7516469 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
FYN ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16387660 17053785
FYN SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17474147 16713569 9856337
FYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8395016 10586033 7682059 16713569
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
SYK GRB2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12456653 9341187 9705962 19372136 11071869 11449366 11909947 9697839 21822214
STAT5B GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 8810325 33961781 8695800 7510700 8626525 34407391 16520382 10570290 16906159 16893902 7642581 8816480 9447984 12577067 11964172 8112292 8493579 7664271 16713569 7516467 19380743 9009162 10207103 17474147 10477741 32062451 7629138 21706016 20473329 19323566 9872323 32203420 7514169 21988832 28166272 28514442 9716598 11997436 9344843 15192046 10716926 8479541 14679214 8943292 31980649 7629168 7559490 9478994 7527391 8188688 11960376 10025673 11726515 7773779 10319320 9569023 9797459
STAT5A GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 SHC1 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 SYK â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
GRB2 NCK1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 NCK1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SYK â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
PTPN11 GRB2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10358138 11447289 11572860 12138178 12707331 15240681 15699106 15713798 19833085 9751747
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 SYK â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
SYK GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11964172 16189514 22267732 10747947
SHC1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 198.0 1.0 Omnipath 8808684 9083103 8551221 9126968 8621483 25416956 9252386 8524223 7535773 8662998 11302736 11827484 8995379 9541596 9175774 10207047 7717978 17673906 7744881 11505033 10523831 24189400 9927207 7650032 8810340 9045692 23178716 19531499 15812354 9129019 10356320 12485888 9461587 8114695 7514169 9566877 8939605 16371368 15341520 7529871 10891441 10749687 7524086 26645482 8491186 10592173 10049786 9171350 11707404 7537740 15688026 8663178 19380743 11782427 9544989 16436051 9434624 16713569 21725358 11964172 17314098 11792427 8195171 1465135 12213123 8647288 12955078 10477741 11707405 12577067 9199344 10080542 8112292 7760801 10570290 11997181 7798267 16520382 10961885 8950973 21706016 9448048 8662733 11370743 8051109 9733714 8621475 9254595 8294403 10748054 8621719 8940013 12441060 22057045 7505797 24737791 20697350 9886492 18174162 18273058 8235613 7963520 7523859
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
PTPN11 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 8702859 9361008 16371368 21706016 8041791 11085989 8978300 11432792 15882975 9362449 10212213 11684012 7523381 10592173 16189514 10747947 10973965 9632781 8959326 11602579 12577067 9254654 10080542 15010462 31585087 12531430 8995399 19380743 7522233 9804835 7534299 9824671 9660791
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
SHC1 HBEGF â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
HSP90AA1 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRG2 HRAS â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9069260 9113989 9235916 21779497 11739523 10545207
HRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9069260 9727023 17145710 10922060 11136978 21779497
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
NRG2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
HSP90AA1 SHC1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
HSP90AA1 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HSP90AA1 NRG1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
HSP90AA1 PLCG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
SRC HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17855507
ITCH YAP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 21107885 21383157
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRG2 KRAS â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TP53 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11514734 18555006 10953306 14741382 19107228 20124454 8274455 16061648 10448271
KRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9727023 16189514 10542052 21779497
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
SRC MUC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11483589 11152665 14521915 21798038 15212693
SYK NCK1 â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SHC1 NCK1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 NCK1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SYK NCK1 â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SYK NCK1 â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
NCK1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
NCK1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
NCK1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17145710 10026169 10206341 7862111 17474147 8810325
NTRK2 NCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12074588 16713569
NCSTN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 12603837 23331499 21071413 14572442 12471034 10993067 18201567 18988627 12032140
PIK3R2 NRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRG2 NRAS â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7923364 11560935 9690470 21779497 8493579
NRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8052307 7820549 9150145 8665852 21779497
SHC1 NRG1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRG2 SHC1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
SHC1 NRG4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
NTRK2 SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9507002 19166614 12074588 16126371
NTRK2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12601080 12419535 17081983 16038803 1689310 1708307 10092678 7682059 15144186 8885868 16126727 15592455 8657103 12074588 16153436
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
PIK3R3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8596638 22402981 9415396 11733063 26496610 25814554
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3R1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9113989 8596638 21827948 12147247 11733063 22020336 24165795 31031754 14665640
SHC1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
TP53 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10321740 19763735 21057544 18661553
PTPN11 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 11593409 18950707 15790353 23109003 16371368 17722974 22315502 16107703 9660791 9918857 8080844 9632795 10973965
PPM1A PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15016818
PTPN6 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21780115 11337495 11526404 15032589 9065461 11160222 23109003 22880054 10488096
SYK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921024 15536084
SHC1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19531499 8662998 7537361 19380743 8621719 16135792 9541596 16219545 16713569 23397142 19889638
PIK3R1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 19531499 25241761
PIK3R1 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 25241761
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
PTPN6 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21780115 15032589 11526404 23109003 9065461 22880054 10488096
PTPN11 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18950707 23109003 16371368 17722974 22315502 16107703 9660791 8080844 9632795 15790353
PLCG1 SRC â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
PLCG1 SRC â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
SHC1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SRC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 8388373 16497976 16126727 16713569 17389395 1689310 20068231 17570479 16153436 16038803 1708307 7682059 7510703 18594017 12601080 8885868 8657103 17016520
SYK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17081983 19690332 8627166 16497976 15592455 16126727 17389395 19534553 1689310 20068231 10592173 16153436 16038803 1708307 7682059 15144186 9697839 7831290 7744830 12601080 8885868 8657103 17016520
RHOA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12071848
PLCG1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15953601 12084069 7629168 9020117 16713569 10913276 17474147 10940929
PLCG2 SOS1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11390650 20484116 10811803 12471105
SYK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771181 19783684 12470302 16449524 14656219 10469124 10933389
SRC PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 30819914 12181444 11606584 14656219 7682059 15144186 11507089
PSENEN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12522139 12198112 15322109 16189514 21115843 12639958
PTK6 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17997837 21205088
PTPN11 PTPN6 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PTPN6 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18757826 18482983 10698938 17974954 14687660 24632723 20308328
PTPN11 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12577067 9632781 9344843
PTPN11 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10617656 18508557 12220225 16189514 12060651 12237455
PTPN11 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10617656
PTPN12 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20697350 8939605 12052829 24189400 24412244 7929214 20075861 19380743 11342545 8626541 11432829
PTPN12 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19595712 18482983
PTPN21 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7519780 15143158
SRC PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8692915 17675340 14551136 25535246 14699166 12468540 10574931 16649996 8647855 7512963 9261115 34010642 14757045 12468645 8114715 15212693 10488096 21900501
PTPN6 SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12763134 11356834 10592173 16189514 10458769 10072516 10747947
SRC RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11389730 1717825 16713569
SMURF1 RHOA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
SMURF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15761148 21572392 16472676 16622418 28658604 15710384 14744429 14657501 22949611
USP8 RNF41 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15314180 23750007 17035239
TP53 S100A4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19740107 15116098 23752197 20591429 20070253 11527429 12942774 31837246 11278647
S100A4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19740107 15116098 23752197 20591429 20070253 11527429 12942774 31837246 11278647
SHC1 SYK â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SHC1 SYK â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SHC1 SYK â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11907067 11960372 12175651 12393695 12524384 12629515 12640133 13678960 14568985 15099563 15111329 15501236 15520864 15536084 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17101731 17496910 17673906 17883421 19414323 19449109 19909365 20150200015 21149606 21372296 21378271 21910624 22064427 22461508 23390297 23609447 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8189062 8226994 8551221 8837607 9000133 9157999 9295024 9314552 9396765 9570538 9632805 9753319 9763615
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
SYK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 19901323 9388490 9096689 16497976 15592455 9121430 10891441 17389395 11687594 10482988 20068231 10592173 9685404 9927207 15688026 7896829 9199344 9710204 17016520 11075717
SHC1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 9544989 8631299 8621483 8950973 10891441 10783152 9278309 17673906 9344843 8294403 8021500 10025673 7520523 12955078 12577067 9199344 19531499 7760801 10570290 19380743 8235613 10675333 8114695
SYK SOS1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12456653 9341187 9705962 19372136 11071869 11449366 11909947 9697839 21822214
SRC SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 9856337
SRC STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19438593 12429742 17997837 12621061
SRC STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11413148 17081983 10358079 22090359 7925280 16189514 15702476 11641791 15212693 8617237
SRC SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7513017 17353363 17570479 16189514 9389695 23100514
SRC WWOX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 32185845 26120275 31752354 25441426 19366691 16115915 16288044 18371080 27551439 27845895 25650666 31315632 12514174 15070730 15664696
TAB2 TAB1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 TAB1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TRAF6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21305609 17145710 11809792 12242293 19775907 10882101 25290089 10094049 30782845
TRAF6 TAB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF6 TAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 17145710 15492226 19675569 15932500 18180283 16251197 10882101 18299187 11259596 1551980 24061540 21988832 19112497 22924441 11518704 11809792 15836773 14633987 14751757 25290089 12496252 12609980 12242293 24735611 14982987 15327770 17720800