Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
IRF3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21952047 23532979
IRF3 TBK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18583960 6948053
IRF3 TBK1 â—¼   COLOCALIZATION 2.0 0.8 intact 17599067 5220070
JAK1 IL12RB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24743305 24572363
EPS15L1 EPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9723620
JAK1 CNTFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12707266 7852997
JAK2 CNTFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12707266 7852997
ABL1 CNTFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CNTFR CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CNTFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11464862
ABL1 MAP4K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 NOTCH3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18619508 23418320
PRKCA ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10713049
SRC ABL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CRK ABL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL2 CRK â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15886098 5217726
SRC ACTB â—¼   COLOCALIZATION 2.0 0.8 intact 7296071 19903481
PRKCA ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15590896 10592173
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
AP2S1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2A2 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2A2 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AURKB STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17199039 16537398
IRF8 BCR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20237505 14656881
BCR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8978305 21602891
ERBB2 BLNK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
BMX ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
BMX CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
BMX CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17474147
CAPN2 F2RL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10978167
YES1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
CSF1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
F2RL1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217522 15708858
FCGR1A CBL â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6548125 9716598
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL F2RL1 â—¼   COLOCALIZATION 2.0 0.8 intact 5217522 15708858
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
PIK3R2 CD247 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD247 CD3G â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD3G CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD247 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD247 PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
HLA-DRA CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 CD3D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD3D CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3D PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
CD4 CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3E PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD3E PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
PIK3R2 CD3G â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
CD4 CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA CD3G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD3G PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
CD3G PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
CD4 HLA-DRA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD4 HLA-DRA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
FASTK CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GHR CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ERBB2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
HCK CSF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
YES1 CSF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
CSF1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
CSF2RA PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
PRKACA CSF2RB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
CTNNB1 STMN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17273793 16712787
CTNNB1 IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592430 12782598
PPP2CA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10644691 19061640
HSPA5 EPS15L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
JAK1 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 SOCS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
PIK3R2 FCGR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
HCK FCGR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8064233 16189514
KLB FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17623664 29648978
HCK PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
SRC HGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17574028 20802513
HIF1A MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12606552 15385570
HIF1A SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20003295
HLA-DRA PRKCQ â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16978534 12473184
HLA-DRA PTPN22 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 22426112 16461343
HSPA5 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 UBE2V1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA5 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IFNAR1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18929502 23331499
SOCS3 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
SOCS1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
IFNGR1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 376230 7617032
IFNG PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9218597 21178011
SOCS1 IFNGR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
SOCS3 IFNGR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
IFNGR1 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
SOCS3 IFNGR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
SOCS1 IFNGR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
IFNGR2 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15120645 23331499
IFNLR1 IL10RB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
IGF1R PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 7541045
IL10RB JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 12974481
IL6ST IL11RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7957045 8637716
JAK1 IL11RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7957045 8637716
JAK2 IL11RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7957045 8637716
SOCS3 IL12RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 18708154
IL12RB1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10198225
IL13RA1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8609418 23331499
JAK3 IL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RB IL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL20RB JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12941475 23331499
IL2RA JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RA IL2RB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RA JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RA IL2RG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RG JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8041779 24608040
IL2RG PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10421845
IL3RA PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA IL3RA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
IL4R IL4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10219247 5211389
IL4 JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12223527 23124025
PRKACA IL5RA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
IL6R JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11557047 5214538
SOCS3 IL6R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17312100
IL6R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11557047
IL9R JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9535918
INS IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9609109 15316008
PRKCD INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11266508
IRF8 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16484229
IRS1 LEPR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
SOCS3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12228220 23115649
SOCS3 JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
PRKCA JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219626 17290288
JAK1 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
LEPR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16173077
LIFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11294841
JAK2 OSMR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8272873 10586060
JAK2 PIK3R5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
JAK2 PRKCD â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
LIFR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11294841
SRC JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 17158356
KIT PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7539802 7520444
LAT PTPRJ â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 11259588 6673177
SOCS3 LIFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17312100
MAP4K1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PRKCZ MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667433 17646398
PPP2CA MAPK15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16336213
SOCS1 MPL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10517496
NGFR TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
PAK2 SORBS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218167 16374509
PAK2 YES1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218167 16374509
PRKCA PRKCE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
PRKCD PTPN22 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0706233104 18056643
PRKCE PRKD1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0809661105 19011111
PRKCQ TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18772140 17948050
RIPK1 TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TGM2 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907907107 20080707
SRC YES1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TUBB TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBE2V1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1551980 11057907
CRK PFN1 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
ERBB2 PIK3R2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
CBL HCK â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
TUBB4B UBE2V1 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
MDM2 AKT1 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
AKT1 MDM2 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
YWHAQ CBL â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 8005785 11697890
KIT CBL â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 25737303 16780420 15315962 8950973
FGFR1 CRK â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 10464310 25241761
JAK1 SOCS3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 10373548 10707961
IL6ST JAK2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
TUBB2A TUBB4B â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
AP2A1 AP2S1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
ABL1 EPS15 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19380743 17474147
PAK4 ACTB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29100370 19778628
ARMC6 EPHA4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CDK4 JAK3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
IGF1R ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30898150 17307140
FGFR2 FGFR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SOCS1 JAK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29674694 11133764 10707961 29991678
TUBB TUBB1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
TUBB2A TUBB4B â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
IL10RA JAK1 â—¼   UP_REGULATES ✅ + 0.82 0.82 Signor 26260587
JAK1 IL10RA â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 10433356
HLA-DRA INS â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
ACTB MDM2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24583282 17373842 24798327
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CBL BCR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20675402 8621719 14725908 8641358 19380743
BCR KIT â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 8757502 25241761
WEE1 CRK â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11839808 16713569
RIPK3 EPHA4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
EPHA4 FGFR1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 16365308 18790757
OSMR ERBB2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25241761 11821958
IL21R JAK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11418623 11016959
INSR JAK2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12456798 8912646
TRAF6 LAT â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25907557 23514740
CD247 CD3D â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CD3D CD3G â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
IGF1R INS â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CRK MAP4K1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
FGFR1 KLB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
TUBA1A TUBB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
IFNAR2 STAT2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
AKT1 IRS1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
HCK BCR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9407116 8955135 12522270 12592324 9178913 10849448
SRC BMX â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16189514 10688651
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
EPHA3 CRK â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11870224 16713569
SOCS1 CSF1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11297560 29991678
HLA-DRB1 HLA-DRA â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5220278 7477400
SOCS1 IGF1R â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32700452 9727029 29991678
SOCS1 IL2RB â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29674694 11133764 29991678
SOCS1 INSR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11342531 15169905 29991678
OSMR JAK1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10586060 28514442 33961781
PRLR JAK2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20962278 10772872 9202403
PFDN1 PFDN5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
TUBB1 TUBB2A â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
TUBA1B TUBB4B â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
ERBB2 LRIG1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ABL1 JAK1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9774693 12130510
ABL2 ERBB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22973453 16273093 19275932
CRK BCR â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19380743 8978305 8943292
CRK FRS2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12154000 10092678
EFNA1 EPHA3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8070404 9195962
HCK KIT â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24728074 11071635
SOCS1 IRS1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12228220 11208867 17276034 29991678
KIT JAK2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7527392 9355737 8611693
TRAF6 TRAF4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25241761 16052631
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
PARK2 UBE2E2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
AP2A2 EPN1 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
KIT ABL1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24728074 12374739
ABL1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
ABL1 HCK â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 9407116 10849448
IL2RA IL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17032757 1993646 16477002
SOCS1 KIT â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10022833 29991678
SRC PAK2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12215529 16374509
TRAF6 SRC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22447928 10635328 16189514 29545793
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
SOCS3 YES1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
FGFR1 FRS2 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 9182757
PIK3R2 TGFBR2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
TUBA1B TUBB1 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CSF2RB JAK1 â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
EPS15 AP2S1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 19380743
CRK SOCS1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25814554 10022833
DDR2 SRC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11884411 16186108
IL2RB JAK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SRC KIT â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24728074 12444928 12878163
IFNAR1 STAT2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CRK PDGFRA â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CRK SRC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
NGFR TRAF6 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
TUBB TUBB2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
TUBB3 TUBB4B â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
CBL YWHAQ â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CSF2RB JAK2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IL20RB IL22RA1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IL6ST JAK1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
IRS1 JAK2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
LRIG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15282549 20126551 23723069 15345710
IL2RB HGS â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21362618 18445679
IL6ST SOCS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
SOCS3 INSR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12560330 15514089 11071852
STK4 MOB1B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24255178 22863277
HCK KHDRBS1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IGF1R MDM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TUBB TUBB2A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
INS IGF1R â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 1851182
CD3D CD3E â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EPS15 HGS â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
AKT1 PPP2CA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL PIK3R2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
TRAF6 UBE2V1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
LIFR CNTFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11943154 12707266 11285233
ABL1 ABL2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 27229929 12569093 15735735
EPS15 AP2A1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 8662627 9049247 10764745 19380743 10953014
FRS2 CBL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17944804 20038681 11997436
EPHA4 EFNA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 19836338 8755474 10366629 16189514
TRAF6 YES1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
IRS1 PIK3R2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
PFDN2 PFDN5 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CBL SORBS1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
KHDRBS1 SRC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
JAK2 LEPR â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
FGFR1 FRS2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
AKT1 MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
CTNNB1 IRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20453844 9541017 16154084
IRF3 TBK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843640 20304918 18636086
IL6ST IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24743305 22306691 12829785
IL12RB1 IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
SRC ABL1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11494128 12522270 11781820 17318191 17474147
ABL1 MDM2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12110584 25624478 16702947
IRF8 ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20237505 24753251 14656881
CLK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18794806
YES1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16787943 11847100 16076903
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
AP2A1 EPS15 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CFLAR ATG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19838173
SRC CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22203672 29899407 17141222 18996392 12941616 15135048 18273061 10829062 31120930 19861161 7782294 16713569 8635998 11994282 17094785 16636290
HCK CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10092522 11896602 8995358 22974441 10799548 11239464 11994282 9890970
CBL PPP2CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
LRIG1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15282549 23331499
IRS1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10854852 19546233
CBL IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18632619 17635922 10514377
ITGA2B CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
EPS15 CRK â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 31980649 7797522 16713569 19380743
CRK RAP1B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
CRK RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
PTK2B CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10329689 16713569
CSF1 CSF3R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16492764 23331499
CSF1 CSF2RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 10572088
INPPL1 CSF2RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
JAK2 CSF2RA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
CSF2RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8977526 23331499 9028317
INPPL1 CSF2RB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
JAK2 CSF2RB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
CSF3R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 7775438 11812652
CSF3R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 7512720
PRKCD CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25639486
EPHA3 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9632142
MAPK14 EPS15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24269888
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 19704002 21075308 7542762 7797556 19372587 29720121 11940572 17875712
KLB FRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10629055 9660748 18373495
GHR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 10502458
HIF1A TUBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18178340 21176881
IL10RB IFNLR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12483210 23331499 12974481
IL10RB IFNLR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12469119 21716315 23291588
IL15RA IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17709786 15265897 7641685
JAK1 IL20RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27133025 1662392 16750817
IL20RA JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12941475 23331499 15120645
IL2RG IL21R â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11418623 11016959 12093291
JAK3 IL21R â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11418623 11016959 12093291
IL21R JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12093291
IL22RA1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12941475 23331499 15120645
INPPL1 IL3RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
JAK2 IL3RA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
INPPL1 IL5RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
JAK2 IL5RA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
IL6R SOCS3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 11306493 12754507 24418198
IL6R SOCS3 â—¼   SHARES_COMPLEX 3.0 0.9 ACSN 11306493 12754507 24418198
INPPL1 JAK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
SOCS1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12228220 17276034 11208867
LTK IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9223670
PRKCD ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11389095 12919677
SOCS3 JAK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10421843 9344848 14517242 15514089 29752723 22342841 24438103 10882725 24354892 11314018 19543316
OSMR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10586060 23331499
SOCS1 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27144517 11133764 21508344
JAK3 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
MAP2K2 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK10 STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20630875
PAK6 MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK14 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15649893
PPP2CA MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983168
NGFR STMN2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YES1 PAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16374509
PIK3R2 PDGFRA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
SRC PPP2CA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
PPP2CA PRKCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10592173 9675027
PPP2CA STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21199877 23431053
PRKCE PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10092595 12407104
RIPK3 RIPK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19524513 30420664 29497034 22864571 26786097 31358971 22817896 23744296 26559832 19524512 26319693 22265414 22265413 29352166 29883609 21903422 24098568 25882049 10339433
SOCS3 SOCS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17363902 14512302 9885206
SOCS3 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18055217 16543409
IL6R IL6ST â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
AP2A2 EPS15 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
JAK2 SOCS3 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
ABL1 CBL â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
JAK2 SOCS1 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
TUBB1 TUBB3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBB TUBB3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBA1B TUBB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
EPN1 EPS15 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
IRF3 TBK1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
INSR IRS1 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 7651388
TBK1 IRF3 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17599067 5220070
TBK1 IRF3 â—¼   PHOSPHORYLATION ✅ 0.92 0.92 mint 6948053 18583960
TBK1 IRF3 â—¼   COLOCALIZATION ✅ 0.92 0.92 mint 17599067 5220070
JAK3 IL2RG â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 27742835 7973659 7973658 16189514
CD247 CD3E â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
INSR IRS1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
ARAF MAP2K2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
IL13RA1 IL4 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
IL20RA IL20RB â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
TUBA1B TUBB2A â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
STMN1 STMN2 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
CD3E CD3G â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
IFNLR1 JAK1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
IL10RA JAK1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
IL15RA IL2RB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
IL15RA IL2RG â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
IL13RA1 IL4R â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
TUBB2A TUBB3 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
IL2RB IL2RG â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
AKT1 STK4 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 19940129 17932490
CD3G CD3E â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 9582308 2138083 20890284
SOCS3 LEPR â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 11018044 21239736
ACTB PFN1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
TUBA1A TUBA1B â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
IFNAR1 IFNAR2 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
TUBA1B TUBB â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
TUBA1B TUBB3 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
IL2RG IL2 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 16477002 10662798 8006584 8049354 22446627 11418623
JAK1 IRS1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 11162588 7499365 9492017
JAK2 IRS1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 15316008 11208867 9492017 12960006
SOCS1 JAK2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 11971965 18508766 19287004 9344848 10421843 14517242 11314018 29991678 10064597 11713228 29674694 9202126 14522994 10455112 28258213
TUBA1A TUBB3 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
TUBA1B TUBB2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CRLF2 IL7R â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
EPS15 EPN1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10791968 18375383 18200045 15809337 9723620 21115825 16429130
EPN1 AP2A2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 12057195 9723620
AP2A1 AP2S1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
INS INSR â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ABL1 CRK â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TUBA1B TUBB3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TUBA1A TUBB2A â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
EPS15 AP2A2 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 10809762 18362181 8662627 9049247 26822536 19380743
HLA-DRA HLA-DRB1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
AP2A2 AP2S1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRK â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 PFDN2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN1 PFDN5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PFDN2 PFDN5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
TBK1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 24549848 18583960 22072751 16380379 26811330 16127453 17618271 23478265 19153231 12692549 28618271 17599067 22388039 15841462 25636800 21903422 15210742 33990776 20532218 16699525 20170763 30842273 12702806 16306043 17018283 20628368 16914100 33411856 23746807 28159912 16394098 18356163 22904301 34379517 22810896 14703513 22750291 27548204 29800227 22079989 24056301 14679297 17706453 20511230 24396068 19211767 18440553 16281057 12524442 16625202 9463386 19893624 18636086 15749911 18818105 27125670 24807708 15695821 9566918 30496178 17526488 19656901 23028469 32351706 24371060 15367631 16199137 25803835 24622840 16155125
JAK2 IL12RB2 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL12RB2 IL12RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB2 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL12RB2 IL12RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL2 IL12RB2 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
EPS15 EPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16429130 18375383 35044719 9723620 10393179 18200045 15809337 21115825 10791968
HIF1A LOX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19828020 20956321 18037992 21239473 17685448
ABL1 CBL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CRK â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
PAK2 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 18161990 20841568 11121037
HCK ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 18775435 9407116 12522270 16787943 28087699 11847100 26473374 16912036 16076903 20841568 24708674 10849448
SRC ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 19901323 10964922 16497976 20841568 16787943 17570479 17318191 11847100 10500097 12522270 18691976 11494128 11781820 16076903 20168609 12748290 16464493 12445832 19369195 17474147
ABL1 PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18923184 17126298 9109492 16631755 19737086 28637715 20841568 10713049
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
ABL1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9525940 11494134 16713569 20841568 10829062 17389395 16955467 12604776 9890970 10391678 9195915 14725908 7925293 11997497 12522270 15556646 9102067 11239464 11994282 9174058 12475393 20675402 19380743 14604282 8626543 15212693 19823681
ABL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23331499 12110584 20651945 29065514 22352870 16702947 25973395 27626309 21081495 27956626 20841568 14757045 19738896 15212693 28690977
ABL1 SORBS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 24475245 12475393 18559503 21071413 9211900 20841568 18768933
ABL1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12560071 20841568
ABL1 CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 19901323 26944284 15689152 19690332 16497976 24975575 19413330 20841568 18083107 19534553 20068231 19700222 9038181 14757045 23348931 11113134 10896159 18691976 28646794 29063113 24600352 12372285 19369195 18794154 15212693
ABL1 BCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9407116 10405761 12522270 11780146 8622703 9178913 1712671 12124177 7529874 9467953 8955135 20841568 8112292 16912036 12543778 11376433
ABL1 PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23329794 12637538 16891660 28174535 20841568 12505989 15212693 15024053
ABL1 MAP4K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11278340 17474147 9346925
ABL1 ABL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12569093 15735735 20841568
ABL1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26721416 27618557 24868554 21715626 30903103 22590567
ABL1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16705159 15923602 15793561 25821558 9111318 15143187 16705160 11593427 20841568
ABL1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 100.0 1.0 Omnipath 8978305 9747873 9480991 19426560 17081983 23124138 16522685 16713569 20841568 18768933 8875975 25860930 21779437 19534553 16187300 17515907 21602891 16267043 20068231 10592173 17570479 8194526 7926767 11080615 25381819 12198159 9642287 15696159 18619508 18835194 11956190 22848689 11314030 9480911 19001122 19402756 20697350 12384576 24412932 7542925 11380621 12799422 19380743 12955086 17474147 17016520
SRC ABL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12748290 12522270 19534553 20841568 18083107 17474147
HCK ABL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12748290 20841568
ABL2 SORBS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 21071413 9211900 20841568
ABL2 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 12198159 9642287 21602891 20068231 11956190 19380743 15886098 16713569 8194526 8875975 25814554 17474147 17016520 9480911
PFN1 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17541406 8413665 563468 10600384 10411937 10592173 19000816 16189514 19338310 9463375
AKT1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
PPP2CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 21159657 26256536 15743829 10026142 20452955 11438723 18559511 11839802 19996169 19216069 16406523 10995457 18042541 19556239 18588945 16680151 11087733 18160256 15367694 18039929 18077353 11812651 16044149 20360384 12637511
TBK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21329883 21464307 21106850
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
INS AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 29432553 23912456 11679435 23866690 17335965 24646332 23798298
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22619175 19369195 19737514 19940129 17932490 23431053 11805089 24872389 23893242 17726016
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
AKT1 CFLAR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19339247
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 11756412 11923280 20856200 20452955 20398329 18332867 19664995 10217147 11154281 19216069 20214616 11463845 19166854 15527798 9829964 17570479 16680151 17646672 12145204 15169778 15140942 25241761 11715018 25209720 17680028 21930127 11504915 29311840 15574337 23397142
AP2A1 HLA-DRA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8397411 10480952 9202021 15749704
AP2A2 HLA-DRA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8397411 10480952 9202021 15749704
HLA-DRA AP2S1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8397411 10480952 9202021 15749704
SRC ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9020159
ARAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 21988832 18039929 24746704 16189514 32296183 25852190 21779497 11909642
CFLAR ATG3 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 12215447 15760909 17462996 19838173 23301705 23377657 23725295 24070470 26972597
HCK BCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9407116 12522270 10405761 12592324 19690332 9178913 7529874 17570479 16497976 8955135 16912036 18083107 10849448 12124177
BCR YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17081983 18669648 18691976 20068231 9360956 16045749 98030561 19664995 19415658
SRC BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 27601470 17570479 16189514 10688651
PRKACA CAPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11909964
HGS CBL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
CRK CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRK CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CBL RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CBL CD247 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11353765 15169881 18835194 20189481
PTK2B CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11149930 15128873 16713569
LTK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9223670
FRS2 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20038681 11997436
PRKCA CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10358153 17570479 25814554 11024037
YES1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10092522 11994282 11997497 12522270 9525940 12604776 9890970 9102067 10829062 10799548 11239464 10934191
PTPN22 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10068674
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
HCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 10092522 11994282 9525940 8995358 12604776 9890970 11896602 10799548 11239464 10934191
CRK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 8683103 16289966 8626543 8621483 9617486 16713569 9416834 8524328 10962563 8626404 9367879 8662998 12393469 11792427 15581361 9013636 15581362 9178909 9988765 18835194 8943292 20697350 9129019 19380743 25814554 9461587
SORBS1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15128873 9447983 17548467 12504111 12765336 11001060
INSR CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11997497 10635327 11994282 12522270 9525940 12604776 10592173 17570479 9102067 15951569 10829062 15212693 11239464
CBL PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9234717 10347229 18988627 17635922 10514377
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CBL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 9092574 19190244 11406619 11133830 7629144 17635922 11526404 8662998 8995358 8080844 15107835 23109003 17722974 8621719 16107703 9414268 10514377 15790353 19531499 22315502 19380743 25814554 9461587
CBL KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9092574 17904548 25737303 8950973 15315962 17635922 10514377
CBL SORBS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12475393 15128873 20886612
HLA-DRA CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD247 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD247 PAK2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16188976 16282498 10607567 16979207 11160719 10618429 11070003
CD247 FCER1G â—¼   PHYSICAL_INTERACTION 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
CD247 FCER1G â—¼   SHARES_COMPLEX 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
HCK CD247 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12524384 21910624 24445665 8064233 8132624 8478617
CD4 CD247 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD247 IL2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10562324 11062502 11353765 11385609 12731048 15536084 20814939 21059766 23414611 8478617 9625766 9738502
CD247 LAT â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 7600293 8478617 8642247 9625766 9738502
CD247 FCER1G â—¼   DOWN_REGULATES ✅ - 39.0 1.0 ACSN 10358164 10562324 10925299 11353765 11385609 11438547 11449354 11489965 11513144 11875494 11994457 12055234 12393695 12731048 12811837 15081523 15099567 15778339 16287995 16713974 17100877 18768831 20435894 20814939 21059766 2139103 22267813 23414611 23508573 24378531 24445665 7523143 8344348 8478617 8551221 9603467 9625766 9738502 9751747
CD247 PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
PTPN22 CD247 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16461343
HLA-DRA CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 CD3D â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3D PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3E â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3E PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA CD3G â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD3G PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD4 PRKCQ â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CDK4 CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK7 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7533895 14597415 19847258 8139570 12814430 17386261 16327805 16782892 28368408 17884153 19667075 15703371 14754892 12648680 11900249 12459251 16697054 19809470
YES1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18479465
CDK5 STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16925597 26944284 26708747 20630875
CDK5 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 10544291 12801906 19369195 18691976 9271228 21442427 27169346 17192257 29196663 19415658 7488156
CDK5 TRPV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 26376215 23668392 17194758 23077056 29467671 26902776 22451679 26894912 29352128
CDK5 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11823425
RIPK3 CFLAR â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK1 CFLAR â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 CFLAR â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 CFLAR â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK1 CFLAR â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 CFLAR â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
CFLAR RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12887920 11002417 17047155 10837247
HGF CRK â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
CRK RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
PDGFRA CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 19426560 25241761 10733900 16713569 9546424 27686861
IGF1R CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 12198159 9642287 9480991 9480911 20068231 11956190 8194526 8875975 15522217 17016520
EPHA3 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 21071413 16713569 18988627 11870224
IRS1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9837978 8810325 8621590
CRK MAP4K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 35044719 11432831 9891069 9788432 16713569 17474147 11279207
CRK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 35044719 19380743 25814554 11418612
CRLF2 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18988627 23331499 10872831
IL7R CRLF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11418668 23331499 10881176 10974032
IL4 CSF1 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
CSF2RB CSF2RA â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 CSF2RA â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
CSF2RB CSF2RA â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 CSF2RA â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
IL4 CSF2RA â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
JAK2 CSF2RB â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
CSF2RB IL3RA â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
JAK2 CSF2RB â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
CSF2RB IL3RA â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
PRKACA CSF2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10477722 10949031 9389692 16437163
CSF2RB JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9516124 15988755 9720754 11557047
JAK2 CSF3R â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK1 CSF3R â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 CSF3R â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK1 CSF3R â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 CSF3R â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK1 CSF3R â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
SOCS3 CSF3R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12133942 17312100
HCK CSF3R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9790917 8547634
CSNK1G2 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9360956 16045749 17081983 98030561
CSNK1G3 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9360956 16045749 17081983 98030561
FGFR1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17496910 25241761 22558232 11401320 12040186 19568798 14585353
PRKD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26895471 19141652 29108267
ERBB2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17496910 7702605 7999105 22558232 14517306 11245482 11950845 12040186 19568798 23576562 14585353 23640056
SRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 22605996 16492141 27177845 23824743 25423132 25850673 24816560 27203386 11836526 22515442 26918136 10593980 15782139 9592087 22056988 12571228 17087658 20840866 23640056 21195420 25164010 26453937 9278444 16831887 23476652 12123611 11279024 14517306 21903109 22200182 20026641 22264731 25041845 12408824 22247700
PAK4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28007610 22173096 26068882 25560280 23543898 30755582 29330094 29399291 25335797
PRKACA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 33914026 16199882 22173096 21303971 33815677 22094462 17287208 26068882 26884171 33605402 21506126 24117889 12297048 21822311 16476742
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
CTNNB1 PTPRJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12370829 19167335
SRC DDR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 28270508 11884411 16186108 18083107
PPP2CA EEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8386634 2555220 2176079
EFNA1 EPHA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 93308638070404 24003208 21071413 15114347 9576626 8070404 9195962 11114742 18988627 9330863
EFNA1 EPHA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 24003208 15114347 9576626 8755474 11114742 16189514 10366629 9330863 19836338
HGF EPS15 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
LRIG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15282549 23331499 15345710 23723069 16123311
PRKCA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 18799465 9855018 12040186 19568798 15567848 14585353
PRKACA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18799465 9855018
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
ERBB2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 16273093 1334406 16729043
HCK FCER1G â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 12524384 21910624 24445665 8064233 8132624 8478617
FCER1G IFNG â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 9625766 9751747
FGFR1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12767520 17496910 17673906 25467007
PRKCE FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
MAPK14 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15187187 18039929 18411303 12738796 20626350 11274345
FGFR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15117958
FGFR1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 11447289 11777939 11997436 11877385 12040186 9660748 15173823 25394172 23331499 6321473 16189514 19568798 14585353 17496910 9632781 10629055 21765395 11274345 15574420 9182757 11090629 15567848 16488589
PRKCE FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
FGFR2 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 15574420 11447289 14585353 11777939 16488589 11997436 6321473 9182757 12040186 19568798 15567848 15173823 11274345
GHR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8063815 23331499 10502458 17312100 21347402 18988627 7540178 9211920
HCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
HCK WAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 17145710 18083107 19901323 10068673 12769847 18088087 9742969 19690332 12029088 12235133 16497976 12769846 19234535 15592455 14707117
HCK PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23109003 12495636 17570479 7529876 10593973
HCK KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11071635
HGS HGF â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
IFNG HIF1A â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
IL4 HIF1A â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
HIF1A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14612449 11457733 18752464 17878221
MDM2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15880652 25535359 12606552 25447306 17234751 19696166 10640274
HLA-DRA PTPRJ â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
IFNAR2 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR1 JAK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
IFNAR1 IL15RA â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
JAK1 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR1 IL15RA â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IFNAR1 IL15RA â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IFNAR1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8943354 18508557 8232552 17351669 8524272 7526154 9334213 23331499 10542297 11694501 10982844 15449939 15312780 8702790 8621447 17969444 8605876 10022928 15120645 16171819 29145629 8197134 16987978 24243840
JAK1 IFNAR2 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 IL15RA â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
JAK1 IFNAR2 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 IL15RA â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IFNAR2 IL15RA â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IFNAR2 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12220192 17923090 11786546 9121453 18456457
IFNAR2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9334213 23331499 7988557 12133952 23180781 16710296 18988627
JAK1 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG JAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16467876 7617032 7673114 12438563 10986460 7615558 1396683 8550631
IFNG IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
SOCS1 IFNG â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
IL4 IFNG â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
IRF8 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19074829 21731497 10092656 12429737 21862594 12370291 10358195 2111015
IFNG IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 16110316 12915721 12438563 7514165 15530433 23331499 16237089 23898330 9111318 15143187 16467876 10986460 18988627 1396683 8550631 20304997 11250200 10860730 12165521 29145629 10811850 7617032 18591661 8631301 7615558 7510216 7673114
IFNG IFNGR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12915721 7673114 7514165 12438563 15530433 23331499 16237089 9111318 15143187 16467876 10986460 18988627 1396683 8550631 29145629 10811850 7617032 18591661 8631301 7615558 7510216 20304997
JAK2 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
SOCS1 IFNGR1 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
SOCS1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 18708154 18988627 15522878
JAK1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12133952 8232552 8550631 8156998 7796299 7615558 8649432 19041276
IFNGR1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11438544 15864272 17063185 23898330 12040185 7499845
JAK1 IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
SOCS1 IFNGR2 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
IFNGR2 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7901766 23331499 23898330 7514165 16381926
IFNLR1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15120645 23331499 27133025
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
MDM2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 25241761 28092675 12821780 18632619 17303558 19165858 36042202 20195357
PRKCD IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11884618 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
INS IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 1851182 18988627
SRC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17389395 15212693 18691976 7559478 7493944 7537849 20068231 23472139 8550552 17016520 8940173 9480911
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
IL10RB IL10RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
IL10RB IL10RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10RA â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
IL10RA JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26260587 12374810 23331499 12133952 23180781 12974481 10433356 10347215
JAK1 IL10RB â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
IL10RB IL20RA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 20462497 16982608 14764663 23704922 7543512
JAK1 IL10RB â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10RB â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK2 IL12RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL12RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
IL2 IL12RB1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
JAK2 IL13RA1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
IL4 IL13RA1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4R IL13RA1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL13RA1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
IL4R IL13RA1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL13RA1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
IL4 IL13RA1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK2 IL13RA1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL13RA1 â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 IL13RA1 â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
IL4 IL13RA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12704343 10641437 18243101 18480254
IL13RA1 IL4R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12704343 16682236 18243101 8910586
JAK1 IL15RA â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IL2RG IL15RA â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IL2RB IL15RA â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IL2RB IL15RA â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
JAK1 IL15RA â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
IL2RG IL15RA â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
JAK1 IL15RA â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 7512720 7521688 7523571 7543512
JAK1 IL2 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RG â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RB â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
JAK1 IL2 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RB â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RG â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2 IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 15265897 16477002 10807786 19528259 19833085 7521688 17371980 8049354 15563472 18758473 10662798 15289500 23331499 26755705 8683106 23180781 12095053 11418623 6164929 9625766 24829413 1825141 8006584 16799562 7829965 8568232 10820393 7512720 23650441 20856220 7681595 10849428 22224781 1631559 16212621 21840487 26192618 2965306 8260650 23124025
IL2 IL2RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 6815536 3095922 15265897 12649439 16477002 15933202 1940342 17032757 15178252 8260650 3116143 8894436 1993646 8580082 8960125
IL2 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 8568232 3095922 15265897 16477002 11035066 3098894 15933202 1940342 15178252 8260650 3116143 22446627 8006584 8049354
JAK1 IL20RB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19535621 11564763 11706020 18669613
IL21R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11016959 23180781 12093291 11418623
IL23R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18988627 23331499 12023369
JAK1 IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RB IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
JAK1 IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RB IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RB IL2RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8568232 15265897 11886175 15933202 15178252 1545122 8260650 3116143 8006584
IL2RA IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15933202 15265897 8568232 8260650
JAK1 IL2RB â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
IL2RG IL2RB â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
IL2RG IL2RB â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
JAK1 IL2RB â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10807786 10820393 10849428 12095053 12811837 14607946 15289500 15563472 16212621 16799562 16815076 17371980 17398124 17459805 1825141 18758473 19528259 19833085 19913445 20007590 20856220 21307131 21840487 22224781 23124025 23650441 24829413 25582338 26755705 2965306 6164929 7512720 7521688 7523571 8683106 9625766
SOCS3 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10373548
JAK3 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 7693677 16189514 10825200 7973659 9553136 7973657
SOCS1 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11133764
JAK1 IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9774657 7973658 8700888 12133952 8643566 10373548 7499411 8041779 7973659 9553136 7973657
IL2RG IL2RB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 8568232 15265897 7514277 10903799 11886175 8026467 15933202 7681595 15178252 1545122 8260650 16189514 11851401 8006584
IL2RB IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 8568232 15265897 7514277 10903799 11886175 8026467 15933202 7681595 15178252 1545122 8260650 16189514 11851401 8006584
IL2RB SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10373548
JAK2 IL2RG â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK1 IL2RG â—¼   PHYSICAL_INTERACTION 70.0 1.0 ACSN 10358772 10426994 10485906 10807786 10820393 10849428 10856136 11160275 11371360 11867689 11870632 11907067 12095053 12223527 12244150 12401408 12496409 12811837 12818165 14607946 14610620 15289500 15536084 15563472 16081783 16212621 16243976 16413922 16713974 16785506 16799562 16815076 17371980 17398124 17404308 17459805 17485448 18250477 1825141 18758473 19528259 19833085 19913445 20007590 20184663 20406969 20510870 20856220 21307131 21469115 21840487 22224781 23124025 23390297 23650441 24030977 24091328 24751819 24829413 25582338 26755705 27216177 2965306 6164929 7512720 7521688 7523571 8683106 9625766 9834059
IL2RG IL9R â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 25297818 15143194 1376929 7718508 21439476
IL2RG IL4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL2RG IL4R â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK1 IL2RG â—¼   SHARES_COMPLEX 70.0 1.0 ACSN 10358772 10426994 10485906 10807786 10820393 10849428 10856136 11160275 11371360 11867689 11870632 11907067 12095053 12223527 12244150 12401408 12496409 12811837 12818165 14607946 14610620 15289500 15536084 15563472 16081783 16212621 16243976 16413922 16713974 16785506 16799562 16815076 17371980 17398124 17404308 17459805 17485448 18250477 1825141 18758473 19528259 19833085 19913445 20007590 20184663 20406969 20510870 20856220 21307131 21469115 21840487 22224781 23124025 23390297 23650441 24030977 24091328 24751819 24829413 25582338 26755705 27216177 2965306 6164929 7512720 7521688 7523571 8683106 9625766 9834059
JAK2 IL2RG â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL2RG IL4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL2RG IL4R â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK1 IL2RG â—¼   ENZYMATIC_REACTION ✅ 70.0 1.0 ACSN 10358772 10426994 10485906 10807786 10820393 10849428 10856136 11160275 11371360 11867689 11870632 11907067 12095053 12223527 12244150 12401408 12496409 12811837 12818165 14607946 14610620 15289500 15536084 15563472 16081783 16212621 16243976 16413922 16713974 16785506 16799562 16815076 17371980 17398124 17404308 17459805 17485448 18250477 1825141 18758473 19528259 19833085 19913445 20007590 20184663 20406969 20510870 20856220 21307131 21469115 21840487 22224781 23124025 23390297 23650441 24030977 24091328 24751819 24829413 25582338 26755705 27216177 2965306 6164929 7512720 7521688 7523571 8683106 9625766 9834059
IL4R IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17145710 11815609 12704343 23331499 18243101 8266076 8266078 7918378
IL4 IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 18243101 79183788266078 11418623 8266078 7918378
IL2RG JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7973658 7721895 8580378
IL2RG JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 7973658 7973659 18445337 10856136 16189514 10629052 15621723 7973657
IL3RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15988755 17312100 15795318
IL3RA JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15988755
JAK2 IL4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK1 IL4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4 IL4R â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK1 IL4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK2 IL4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4 IL4R â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10358772 10485906 10856136 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK1 IL4 â—¼   ENZYMATIC_REACTION ✅ 34.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21115385 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4 SOCS1 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
IL4 IL4R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 11786020 17145710 18852293 23597562 23331499 12704343 8639787 2307934 7918378 21889455 10219247 17312100 8266078 11815609 10850446 18243101 2278997 791837811786020 9874253 7721786
JAK1 IL4R â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 IL4R â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL4R â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 IL4R â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK2 IL4R â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL4R â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
IL4R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8609418 18852293 12223527
IL4R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11127821 23331499 12704343 12133952 17312100 23124025 7929391 12223527
IL4R JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 17312100 12207328 7538655
IL4R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9697832 8124718 8599766 12704343
IL5RA JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9516124
IL5RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 9516124 17312100 11823534 7602114 15795318
JAK2 IL6R â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL6R â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL6R â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6R â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6R â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL6R â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL6R IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11238858 8706672 23331499 3136546 14656210 9694899 15895091 23663276 7744875 2788034
JAK2 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
JAK1 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
PRKCD IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12361954
OSMR IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10692570 23331499 21071413 10854424 18988627 8999038 9188471
SOCS3 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10777583 30591653 12403768 24710148 19620279 23454976 10946280
LIFR IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 21071413 24710148 12047380 9716487 8999038 16254248
IL6ST JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7896787 23331499 11468294 9388212 21220115 24710148 11742534 23663276 12487370
IL6ST JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 7896787 8174677 9716487
JAK1 IL7R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8647212 20167604 15996891 20974963 10781830 27729062
JAK3 IL7R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15996891 20167604 7481769 27423467 10781830 22551764
IL7R PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10702271
IL9R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 8756628 23180781 9535918
JAK3 IL9R â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 25297818 15143194 1376929 7718508 21439476
SRC INPPL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 17389395 19901323 17081983 12522270 19534553 12235291 16497976 15592455 15951569 18083107 11349134 18669648
INS INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8393875 21743783 21317886 24296476 26374090 29069585 26245346 16956584 19902173 20332342 23363978 23331499 18988627 23302862 22832498 2550426 15870194 11278498 19752148 29512653 23304064 24633815 17227660 22521887 23223021 30197476
INS IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25309812 25472611 23891856 20150288 29069585 24036112 21518983 11160134 19357636 22198320 17579213 21677282 11684411 23983791 28955049 25760026 21850561 22832498 19808019 22698915 23815272 18443205 20601126 16150913 25383313 27695421 23115649 22728334 19752148 19171749 27819676 16516141 22418434 19542202 25381390 22516431 24763529 26866272 23695665 23431498
SOCS3 INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11071852 25138272 25888955 21873554 12560330 25352752 11325969
PRKCA INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15212693 2110001 12472845 17570479 8454604 1956339 10819237 7926007 92065884 8463287
PTPRJ INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 1715686 10734133
INSR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 10655627 7651388 25472611 1385403 18083107 12220227 23331499 28328746 7504175 19534553 7499194 7537849 7935368 11572799 11781100 10592173 17570479 17575262 18988627 12446583 15629149 10455177 15870194 11416002 12101187 17167487 8530377 8626379 8662806 11606564 2159922 8626723 16020478 16582879
PRKCQ IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15364919 17081983 26956053 25381390 17709744
PRKCD IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 15364919 17081983 16131083 15069075 15199052 23328071 16129690 12031982 15143153 18285345 14583092 16611834 15212693 15516986 16099428 12351658
PRKCA IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869320 15364919 16574739 17570479 15516986 15069075
PRKACA IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17360977 12624099
JAK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7544789 9233603 7499365
JAK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15001544 11591769 8756628 7544789 9305869 11162588 9233603 15592455 7499365 12220227
PRKCZ IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11063744 16129678 16611834 14583092 17360977 15212693 15516986 15069075
IRS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9492017 7782332 11208867 21071413 12960006 15316008
IRS1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 11120660 7559478 10358772 16931767 12730242 12175651 7499365 15316008
ITGA2B RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
ITGA2B RAP1B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
ITGA3 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
ITGA4 PTK2B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
PRKACA ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 21224395 20166139 18578522 23979717 31562188 18583710 18707149 17603879 19401330 12837751 11533025
SRC ITGA9 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11476890 16099633 16919435 17496910 17517963 19734908 22203675 22370635 25572304 26552706 27216177
JAK1 LIFR â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 11306493 19833085 21840487 22595692 24857661 7512720 7521688
JAK1 JAK2 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 LIFR â—¼   SHARES_COMPLEX 7.0 1.0 ACSN 11306493 19833085 21840487 22595692 24857661 7512720 7521688
JAK1 JAK2 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
SOCS1 JAK1 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
SOCS1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 10950967 12223527 10485906 26192618 10707961 12193701 18988627 10201892 10856136 21469115 23663276 11133764 23124025 12811837 9202126
JAK3 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11641425 19901323 20135364 17259970 12207328 10825200 11909529 15659558 12559972 9553136
PRKCZ JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15526032
OSMR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10586060 23331499 15935618
JAK1 PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10702271
JAK1 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 29145629 23331499 10542297 24243840 8197134 10022928 7532278 18508557 16987978 8232552 9020188 12040185 8605876 18988627 10982844 25386349
JAK1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9774657 15021914
JAK1 SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25682267 10950967 16459330 10707961 10373548
JAK2 LIFR â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
SRC JAK2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
SOCS1 JAK2 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
LEPR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17145710 23331499 30044226 17312100 8608603 18718905 12657512 21166956 9092791
KIT JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8611693 7527392 15526160 9355737
SOCS3 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10882725 10421843 23331499 10514492 19543316 21071413 29752723 10551777 24438103 24354892 11314018 15514089 24600449 22342841 18988627 9344848
MPL JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24931576 23331499 10918061 7534285 10224114 10979953 7543416
SOCS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10421843 23331499 21071413 10455112 14522994 10064597 28258213 19287004 18508766 11314018 18988627 11971965 11713228 10975987 9202126 9344848
PRLR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 9202403 21071413 17312100 18988627 20962278 11713228 10772872
JAK2 PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11440634 7651724
JAK3 PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21071413 23331499 9512511
JAK3 SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15385932 10373548
SRC KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9038356 10467411 8766817 22745667 7537265 7516469 11960376 10635328 1374686 18606683 16169070 16713569 1545818 15190072
PRKCZ KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
SRC KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12878163 7520444 10523831
PRKCA KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 7539802 12040186 7693453 19568798 15567848 14585353
YES1 KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11071635
PRKCE KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
KIT SOCS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10022833
KIT PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9092574 17496910 11071635 24728074 10022833 7537096 7509796
LAT PAK2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
PTPRJ LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11259588
LAT PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11368773 9489702 19132916 23109003 14696041
TCN2 LDLRAP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 14528014 23836931 7768901 8710919 8706697
SOCS3 LEPR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 18708154 21239736 11018044
MAPK14 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
PPP2CA MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945 20626350
MAPK10 STMN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11718727
TRAF6 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
MAPK14 MAPKAPK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15187187 20936779 18039929 9628874 23331499 12738796 11274345 11157753 18988627 18669648
MAPK14 PAK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15550393
PRKACA MAPKAPK5 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17947239 20734105 20849292 19166925
PAK6 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 28007610 11960368 11923280 18467333 22349818 23132866 11504915 11715018 28196907
STK4 MOB1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18328708 22863277 23431053 21808241
SRC PAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16374509 12215529
SRC PDGFRA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 7685273 9488729 10508235 9739761
PDGFRA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9988270 17081983 14661060 6273838 15489898 11278940 15845350 12753909 11804588 7578094
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
TGFBR2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9435577
SRC PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 25003662 10978272 21292165 23796501 24676687 22771321 24395787 17635907 26378614 16286244 27013170 23222956 25726524 24997451 31992581 12921784 1325671 17303700 23251465 20558158 21554241 23926298 25931585 22299660 18208556 21791414 23436320 32130916 17394530
PPP2CA PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11959144
PRKACA RAP1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8463283 19651783 27760305 12089143 1551424 90343822
PRKACA STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 7925472 17081983 18767875 17693683 19413330 19664995 19415658 17001604 20068231 18452278 94064639 18669648 8245003 17287340 10913145 19651622 11415983 8376365 8002936 17924679 19664994 8125092 16964243 18212344
PRKACA STMN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 9525956 9126608
PRKACA RAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8463283 9867809
PRKACA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17081983 20166139 2474754 18088087 15546918 19664994 11804588
PRKCA PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15212693 18337243 11741879 11948398 17570479 34010649 10197446 10867018 15024053 15383279
PRKCA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 17496910 11940581 21386996 10527887 2996780 11447289 19615955 16488589 6321473 8321321 12845332 11313945 2136766 17570479 12040186 19568798 15567848 14585353
SRC PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 15851033 14970215 17569658 19366211 26876198 27203386 15961393 24211614 16982614 17570831 23329791 23329794 15541367 18550549 22689788 28637715 14715667 29422059 17658731 10319993 19138410 11927579 29452094 19632318 15337529
PRKCD PTPN22 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18056643
PRKCD PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15212693 11741879 11948398 23109817 21726532 10867018 15024053 15383279
PRKCE SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 11834516 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCE TRPV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 18973552 20808213 16996800 21515378 26171233 11884385 14523239 21480900
PRKCQ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCZ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 10527887 11447289 19615955 16488589 6321473 8321321 12845332 11313945 16189514 12040186 19568798 15567848 14585353
SRC PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12637538 28174535 28842658 17804414 12505989
YWHAQ PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16713569 10092600
SOCS3 PRLR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18988627 23331499 11713228
SRC PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 9560226 20028775 19919693 15585656 12495636 16713569 31979355 18083107 15105428 15778498 10593973 17389395 25349423 19534553 11149930 12486027 10329689 22581436 19380485 15166227 12526812 12522270 23109003 14963038 8849729 20001213 9556630 18935208 12345678 12231407 17192257 7529876 15695828 15070849 20381867 14739300 19369195 11274221 26866924 10777553 10521452 20521079
PTPRJ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18936167 20345711 15735685 10428027
SRC RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
SRC RAP1B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
RIPK1 RIPK3 â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 RIPK3 â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 RIPK3 â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
SOCS1 RIPK1 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
RIPK3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11734559 21903422 22265414 19524512 19524513 22817896 26559832 10339433 26319693 11585904 22265413
SRC SORBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19891780 20841568
SRC TRPV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25970319 16319926 24717323 30292787 15084474 17582331
TGFBR2 TRAF6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 11013220 11133108 12154066 12717440 12724770 12767520 12809600 14557817 15265520 15548370 16474430 17673906 17934056 18758450 18922473 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 22943793 24132110 24336330 7594497 9865696
TGFBR2 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 12717440 19050695 11133108 14557817 19920116 22710166 19114990 12767520 22703233 23331499 11013220 20060931 17934056 21614932 17673906 20644162 24132110 18922473 9865696 22943793 20519943 21900405 12154066 7594497 18758450 15548370 24336330 21278795 12724770 19010789 15265520 16474430 26192618 12809600 19109155