Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ZNF804A ANKRD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23434502
GSK3B PTPN1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673085 7514173
BRCA1 KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221252 8955125
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
JUN BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16229810 17434164
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
NFKB2 CCL19 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12820969 17182562
STAT3 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11279133
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
CCND1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11279133
NFKB2 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
STAT3 CFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22169226
STAT2 CFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16689942
STAT3 CISH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14630083
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
STAT6 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15145939 10373589
CREBBP IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
STAT3 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25453873 28072604
EGFR DOK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
STAT3 EBI3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18389480 14565860
JAK1 EBI3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
JAK2 EBI3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
IL6ST EBI3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
STAT3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731598 14966128
EGFR KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20692258 7987951
PML EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12673202 9819401
STAT1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10558875 22693070
EGFR PTPN1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 9355745 6671413
PTPRG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25624455
TYK2 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23236554 17290288
STAT6 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8415882 23461825
MYC FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20638938 19366810
JUN FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460851 20638938
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN MED14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
HGF STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9094433 9440692
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
HSP90AA1 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
HSPB1 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
JUN HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 20566634
STAT1 IFNAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9121453 6730748
STAT3 IFNAR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18550668
IFNAR1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
IFNAR1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
STAT1 IFNAR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9121453 6730748
PTPN6 IFNAR2 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
IFNAR2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
IFNAR2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11301323 9121453
IFNB1 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10022928 18508557
IRF9 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7843405 20038197
NFKB2 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22547704 24656046
IFNB1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
IFNB1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
IRF7 IFNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16410796
IFNB1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10918594
IFNB1 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10542297
SOCS3 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
SOCS1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
STAT2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9218597 21178011
MYC IGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16707459 15355996
JAK1 IL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
JAK2 IL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
IL12A IL27RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24743305 24572363
IL12A IL6ST â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
IRF7 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164128 16824573
STAT4 IL21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15178704 20620946
STAT1 IL27 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18389480 14565860
IRF9 IL27 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20083668
STAT3 IL27 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18389480 14565860
STAT1 IL27RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18389480 14565860
STAT3 IL27RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18389480 14565860
IL27RA STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 12734330
IL6 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
IL6 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
IL6ST STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662591 6730629
STAT3 IL6ST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9169475
STAT6 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10528163 10882409
IRF9 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10924517 12768031
STAT2 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10924517 12768031
IRF9 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8681971
SOCS3 JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10421843 10064597
STAT6 JAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22254182 17433443
JAK1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
JAK2 STAT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
PTPRG JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25624455
PTPN11 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 8766559
JAK3 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12207328 26758199
JUN NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7541912
JUN SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18571793 17609438
PML JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671405 10620019
STAT3 KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19084525 6979076
PIAS4 KPNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
LCK PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18173375 18759926
LCK PTPN6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 8114715 7028063
STAT4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10702306
MYC SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24285714 24362264
STAT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10637230
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
PDCD1 PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15240681 6731646
PTPN1 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17159996 6672804
PIAS2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12764129 28471454
STAT1 PIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10068671
STAT4 PIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10068671
PML STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12506013 16189514
STAT3 PTPN1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 15821101 6673264
STAT2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
TYK2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
STAT1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 10022928 18508557
TYK2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9794795
SIRPA PTPN6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10660620 6671678
PTPN6 TYK2 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
PTPN6 STAT2 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
PTPRG STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25624455
PTPRG STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25624455
PTPRG STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25624455
SMARCE1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18238828 19785031
STAT1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16195385
SMARCA4 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
STAT1 SOCS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15240659
STAT4 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14559241
SOCS3 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 14559241
SOCS5 TYK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12242343 16451196
TYK2 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
STAT6 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28430601 10982806
TYK2 STAT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
JAK2 PTPN11 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
EGFR JAK2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
IRF1 EP300 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 14662860 23670564 10438822 15509808
JAK1 SOCS3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 10373548 10707961
IL6ST JAK2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
RCAN1 GSK3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 SHIP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 MYCB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
JAK1 INAR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 9334213
ZN692 FBX11 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 FBX11 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 FBSP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SYIM STAT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 ZN692 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
F196A STAT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
KLH10 STAT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
GLPA STAT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 SELO â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 DPP9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PTPN11 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16729043 5218694
EGFR PTPRG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25970784 31980649
STAT2 EP400 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
FBXW7 STAT3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28069035 31843895
RBX1 HSPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25277244 30349055
SOCS1 JAK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29674694 11133764 10707961 29991678
PTPN1 JAK2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 6732089 11970898
PTPN1 JAK2 â—¼   DEPHOSPHORYLATION ✅ 0.82 0.82 mint 6673264 15821101
JAK2 PTPN1 â—¼   DEPHOSPHORYLATION ✅ 0.82 0.82 mint 8287447 201095 21806020
MYC JUN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
SOCS2 SOCS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17898043 29991678
UBP1 STAT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 TACC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STAT2 TRRAP â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CCND3 CBP â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
FBXW7 MYCB2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 25720964 31285543 28514442 29346117
INAR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 8626489 16189514
LIPT STAT2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
JAK3 CXCR4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 10506573 16189514
MYC HSPB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
PIAS2 STAT4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12716907 16189514
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EP300 IRF1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
KPNA1 STAT1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
SMARCC2 SMARCE1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
CCND1 CUL1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
IFNAR2 STAT2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
LCK PTPN6 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
GSK3B RCAN1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12063245 28514442 33961781
FBXW7 MCL1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
JUN PML â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
FBSP1 MYCB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 27173435 29997255 25143387 19398581 24992930 31285543
FBXW7 FBSP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 25720964 31285543
STAT2 EP300 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 10464260 18678383 15154850
STAT3 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730629 8662591
JAK2 PTPN1 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
CBP PIAS3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 14691252 28680062
CBP STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11239394 15653507 15649887
INAR2 UBP18 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28165510 32092142 27716962 16710296
UBP18 STAT2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28165510 32092142 31836668
AURKA BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22110403 26831064 14990569
JAK2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
JAK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
SOCS1 EGFR â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22973453 12070153 29991678
CREBBP STAT6 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
PTPN11 EGFR â—¼   DEPHOSPHORYLATION ✅ - 0.86 0.86 Signor 12582165
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
PTPN6 SIRPA â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
SHIP2 EGFR â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22973453 19713535 11349134
FBX11 RBX1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17098746 22113614 33961781 33504946
EGFR SOCS5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22973453 15590694 15695332
EGFR STAT2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
EGFR PIM1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
EGFR STAT3 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 22693070
MYC EP300 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12776737 16287840 32140074 15616592 16126174 17157259
BRCA1 CREBBP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EP300 STAT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IFNAR1 STAT2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IFIT2 IFIT3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
IL6 IL6ST â—¼   UP_REGULATES ✅ + 0.87 0.87 Signor 8511589
EGFR STAT1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
IRF1 STAT1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IL6ST PTPN11 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
IL6ST JAK1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
EP300 CBP â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 30110629 9267036 15598887 31753913 17970752 25314079 10899165
SHIP2 CBL â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 19880507 19380743 15668240 12504111
AURKA TACC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15064709 14602875 14603251
EP300 CCND1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10567390 15951563 11788592
JAK2 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24240702 23838182 9363897 10358079 10635327 16273093
EGFR HSPB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23397142 15657067 24189400
JAK2 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10551884 16713569
SOCS1 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10022833 16713569 29991678
IL6ST SOCS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
STAT1 IRF1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16512786 10764778
JUN STAT3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10490649 16713569
STAT3 PML â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16189514 12506013
STAT1 STAT3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
FBXW7 JUN â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
JAK2 STAT3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PIAS1 STAT1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CBL LCK â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
JAK1 STAT3 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
JAK2 STAT1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MYC TRRAP â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MYC GSK3B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16247449 20713710 19131971 21150319 31638140 29467282 11877389 33541412 14563837 8247524
FBX11 CUL1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 29103612 21145461 22113614 17098746 23319600
MYC CBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16878156 35140242 29467282 12776737
STAT6 CBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15695802 31554795 11574547 10454341
STAT1 CBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10848577 16481475 25733689 9037008 8986769 15894584 25451029 15695802 19915063
CBP BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10655477 9443979 9926942 12700228 16713569 16860316 11782371 16417649
INAR1 INAR2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26008745 24075985 8969169 21854986 15389589
STAT1 INAR2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 32123171 29997210 11301323 9121453
STAT1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10792030 16713569
CCND1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9244350 16713569 17334399
EGFR HSP90AB1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EP300 STAT6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 23461825 17237818 10454341
NFKB2 FBXW7 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22864569 22388891 32350066 14743216 25720964 33658012
TYK2 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9196040 16713569 16189514
PML JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10620019 16916642 9671405 15626733
PIAS2 MYC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17418410 16352593 18923429 17471507 11283613 30415952 20426839 19786833
MYC PML â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17146439 21150319 32592588 30415952 15735755
PTPN11 SIRPA â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EGFR PTPN1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
PIAS3 STAT3 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
FYN GSK3B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
MYC GSK3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
STAT2 CBP â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 10464260 8848048 28514442 28707474
CBP JUN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18443043 8028671 16055710 2138276 10327051 15994313 16713569 17296604 9786917 9659924
CBP PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17239008 25733689 12234245 12142048 10077561 12622724 16713569 10610177
INAR2 JAK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12133952 29997210 16710296
INAR2 STAT2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17923090 11786546 28165510 9121453 32092142
MYCB2 MYC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9689053 26517351 29467282
STAT2 INAR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12220192 11786546 8605876 7559568 33811647 9121453 15356134 9677371
TYK2 INAR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 95059042 8628273 33811647 24704786 10523853 15356134 9733772 9677371 18474601 15337770 16189514 7526154
FBXW7 AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15592418 33824269
MYC BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11916966 9788437 20215511 30415952 16713569 12646176 14612409
EP300 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10655477 21212407 19887647 22787115 16713569 11782371 21102443
JUN BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25609649 12080089 16713569
EGFR CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23158001 24797263 25872741 31182136 10635327 26055326 14505571 15210722 32714745 23774213 19155296 11370743 19836242 8665853 19947936 18271526 25140053 15668240 22394513 17486068 33323455 32377695 22203672 17182860 12604776 14627991 15383614 23153581 15735736 28541302 16849543 17242169 20562913 32904620 9121472 15677445 7782294 16923119 17995934 19531499 15465819 31959764 32114396 23457600 29629558 18316398 23799367 24714105 31120930 12061819 16713569 7657591 33617900 10086340 19225046 33762435 23175185 16729043 28791635 16246327 28198003 15962011 22266821 15117950 27059931 10428778 12734385 8662998 25005938 27903975 16969069 26177020 8798643 10799548 9756944 15159412 19578043 15657067 18255265 23418353 25754235 22976291 17545148 12803489 18319245 19713535 7592693 30544639 15107835 11994282 17971399 16105874 15282549 20940296 23897813 9130710 18273061 18508924 17880946 20124286 12593795 16914641 20877636 10092522 25521828 11408594 22591401 9890970 20308550 22833562 21772844 33627783 11239464
PTPN6 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11157475 12176909
NFKB2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12808109 20420878 16990795
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
CISH EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16273093 31980649 25402006 24658140
STAT6 CISH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18194215 18342537
IRF1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15659847 10570299 15355347
CREBBP IRF9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8848048 17923090
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
CREBBP IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17923090
JUN CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21465475 17550983 21312239
MYC CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10229837 11145693
CXCR4 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17158356 10506573
EBI3 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22306691 28280243
IL12A EBI3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22487722 18033300 9342359
PTPN1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 6671413 9355745
SOCS3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 25402006 12070153
TGFA EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12297049 24658140 31980649 8663070 10775655 25402006 28988771
STAT3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18367518 21590492 23504318
PTPN1 EGFR â—¼   PHOSPHORYLATION ✅ 0.9 0.9 mint 6671413 9355745
PTPN1 EGFR â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 6732094 9050838
EGFR PTPN1 â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 25796184
EGFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8524316 15284024
EP300 IRF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15509808 10438822
MYC EP400 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 35140242 18413597 21150319 29467282 30415952 20946988 17314511 11509179
HGF PTPN11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17881575 10871282 11323411
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
STAT3 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18266962 12559950
STAT3 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16527988 14715258
USP18 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27716962 16710296
IFNG STAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12040185 7796299 8156998
IRF9 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8864350 22252317 9218597
IFNG STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10707961 11960596 28264935
IL12A TYK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
JUN IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16600913 22904313
JAK3 IL21 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11418623 11016959 12093291
JAK2 IL27 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
IL6ST IL27 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
JAK1 IL27 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
IL27RA IL27 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
IL6ST IL27RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
JAK1 IL27RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
JAK2 IL27RA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14764690 27119567 24771852
IL6 JAK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8134389 8272873 9382798
INPPL1 JAK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9108392 9099679 10570274
STAT4 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10068671 10037767 10358173
STAT1 IRF9 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8943351 17923090 24065129
STAT2 IRF9 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9242679 33961781 17923090 24065129 21903422 8943351 28514442
STAT1 IRF9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
SOCS3 JAK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10421843 9344848 14517242 15514089 29752723 22342841 24438103 10882725 24354892 11314018 19543316
STAT1 JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12223098 21239533
SOCS1 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27144517 11133764 21508344
LCK JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11278738 17570479 16189514
JAK3 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
LCK PDCD1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12947224 18173375 18759926
MAPK1 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
MAPK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18378670 7569900 14963018
TRRAP MYC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 35140242 12077335 17353931 21150319 32140074 16705173 9708738 29467282 11839798 30415952 20946988 17314511 11511539 19818711 12660246 10611234
MYC PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20123981 17382917 22550094
MYC STAT6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
STAT1 OAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23110939 2456211 22305621
STAT3 PIM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 11533249
SERPINE1 PLAU â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
STAT1 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21115099 15519999 22589541
STAT2 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17062732
TYK2 PTPN11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15919823 7512451 20671117
PTPN6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18508557 15870198 10545526
PTPN6 SOCS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 14551136
SOCS3 RBX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
SOCS1 RBX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
SMARCC1 SMARCE1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 20829358
SOCS3 SOCS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17363902 14512302 9885206
STAT3 SOCS7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15677474
STAT2 STAT1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 35140242 8621447 17923090 10446176 24065129 12048190 8605877 10490982 15825084 28514442 9724754 26966684 31836668
STAT1 STAT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16918696 19122651
STAT6 STAT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19324016 17032631 11359632
TYK2 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16324152
SMARCC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
JAK2 SOCS3 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
TYK2 IFNAR1 â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 8605876
JAK2 SOCS1 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
IRF9 STAT2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
STAT1 STAT4 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 35140242 21826217
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
FBXW7 MYC â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
SMARCC1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
EGFR STAT3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CREBBP STAT2 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
EGFR PTPN11 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
IFNAR1 IFNAR2 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
EP400 TRRAP â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
KPNA1 KPNB1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
SOCS1 JAK2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 11971965 18508766 19287004 9344848 10421843 14517242 11314018 29991678 10064597 11713228 29674694 9202126 14522994 10455112 28258213
FBXW7 RBX1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
FBXW7 CUL1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 32086376 14603323 11585921 28007894 23108047 21205095 31285543 29408378 29103612 25143387 25720964 22405651 23322298 28522751 29695787 22388891 23453757 28514442 11565034 29499133 21145461 25515538 32350066 22524983 26976582
FYN CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9677430 8621719 12244174 7782294 10629042 119942 7642581 15556646 12231245 9311917 9535867 8626543 10799548 16713569 16503409 10092522 8900205 8995358 25814554 9890970 15190072 15208330 12941616 10829062 11239464 8662998 17094785
CREBBP STAT1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
EGFR TGFA â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
IFNAR1 TYK2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SMARCC1 SMARCE1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
IL6 IL6ST â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
PLAU SERPINE1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CUL1 FBXW7 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SMARCA4 SMARCC2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCC2 SMARCE1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCE1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL1 RBX1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
STAT3 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16084951 18310224 15184887
GSK3B CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11152665 20537194 10385618 15252116 11124803 16331257 12969793 19757160 16732330 10486203 16039586 14536078 18167338 15326477 12459251 12615961 17092340 15212693
JUN CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
GSK3A MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11018017 17081983 2663470 11877389 14563837 8247524 16023596 15150404
GSK3A MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15241487 16543145
GSK3A JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 1846781 24214991 91332050 1516134 1956339 16023596 92065884 1651323
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
GSK3B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17486076 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
GSK3B MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 18463697 21646472 30037819 26751215 25647305 2663470 20080742 19797085 30003124 16855632 12040186 18679417 11018017 23331499 29229669 16611981 21071413 24265759 20068231 10671551 16039586 17570479 16023596 29258530 12615961 18669648 21113395 22461507 19131971 8247524 16247449 20604938 19575820 15150404 22481935 23668310 19651622 17444818 23964270 20537194 22893788 27684546 24662831 25333250 20399964 11877389 14563837 18408012 17052453 18455992 15212693 16371461 11274345
GSK3B MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 26205817 17463001 28522751 12223490 22751450 26219338 28053206 17387146 20526282 28404959 24779770 24681994 21368834 27349166 28301598 16543145 33658484 15241487 26822034 21368833
GSK3B JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 23331499 1846781 25979842 25241761 20537194 21278055 21397588 17482134 1516134 8384355 17570479 16023596 17215518 30086763 92065884 24632621
GSK3B RCAN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19651622 16415348 21606194 12809556 21709260 12063245 20068231 16126726 17570479 19366350 21406690 17318175
GSK3B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 26907733 16944320 27546592 11967263 14663202 8524413 16504004 29969496 19767775 21347341 25142862 11311237 30736789 14597415 25591548 19645770 10385618 20548028 10766840 10929713 23565238 16039586 17570479 18818515 18167338 12615961 12413951 17046823 19071090 18598945 15465828 19374252 26121043 26432751 18319725 12969793 23733133 22922870 24134204 10486203 12459251 15020233 18769147 10910956 11152665 21317297 20537194 22099186 18328826 11124803 17070615 19757160 22470469 23552696 16732330 27695879 29554905 16103118 15075324 14536078 9832503 28090171
IFR9 STAT2 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
IFR9 STAT2 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
IFR9 PDCD1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 IFR9 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 IFR9 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
RBX1 CUL1 â—¼   PHYSICAL_INTERACTION 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
NFKB2 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
RBX1 CUL1 â—¼   SHARES_COMPLEX 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
RBX1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 154.0 1.0 Omnipath 17053147 12684064 20638939 11967263 19797085 19258535 26540345 18826954 15071497 15448697 21765416 25730849 10230406 23343194 21169563 22270359 19250909 23732914 11359933 12051714 20006983 15361859 10748083 19352404 22682247 18787170 12504025 18636226 16469695 15459660 20211143 10535940 15001769 26725323 19411070 11861641 26159692 16697054 1570337 19751508 22822056 11348595 7542250 7641885 19849719 16759355 12820959 17452440 19622404 15703371 10648623 19245792 23331499 9694792 19150432 23180781 19597341 16189514 22474075 18988627 22767593 17143292 24949976 10713156 23770852 22405651 19942853 18196958 20399188 16713974 26192618 11027288 17884153 19933270 22730322 21411632 11961546 17936032 19809470 15147722 19270156 19576224 11483504 20976471 12504026 24023259 12840033 15340381 12904573 20558317 11900249 14536078 19686080 12565873 18805092 15489953 19557001 26885856 17652783 12481031 20843316 11955436 21071413 16039586 11956208 20705860 8666229 17928543 10023660 19836308 16940750 12706828 19143635 15688063 10671552 16123592 19366350 19847258 12417738 11245432 20832730 12648680 12609982 19619488 10230407 18931676
IRF1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 14581002 1371248 9078371 10358173 17617740 12466898 23670564 23542606 12077266 11473119 17785777 8062214 8621447 7507207 8052267 1712401 7559730 19929594 9315689 10406469 8805641 10321737 7957048 7687740 2911367 1614874 9625761 27012395 9831185 2475256 8004672 15722233 7606736
STAT1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11244574 9325014 11909852 15714000 1833631 14978477 12356687 8454630 17617740 20585034 22589541 8683106 1756724 22252317 11566724 11591697 11972347 18616672 19135978 8509377 10586107 20526365 15664995 8444884 17050680 18562017 7796811 18778729 1315834 17374731 22479354 10406469 21659501 8805641 18024894 19561067 8034722 15467722 23598529 17689680 12748307
IRF7 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 21670437 10933732 12077266 11473119 17785777 9877175 10938111 19798431 11303025 12242290 16612387 16251417 21940674 15265881 12138184 16175599 19349300 10692430 27012395 11162841 17702615
IRF9 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20403236 9186002 22252317 15145216 22626811 8864350
IFNA13 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8181059 10395669 11278538 11698684 21856167
IFNA13 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7932753 23331499 8181059 11698684 21856167
BRCA1 AURKA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 AURKA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
MYC AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20890087 20519624 14744757 20682043
AURKA TACC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15630414 17145710 14602875 14603251 15064709
AURKA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22864622 22340593 18026198 24775809 14990569
USP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 16531995 18082604 18082605 18931676 19075014 19217432 19264559 19622404 19686080 23589330
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
LCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 9525940 10829062 10799548 10934191 7721825 16107303 12604776 9890970 17570479 11904433 9178909 10092522 11997497 12522270 8621719 9102067 11239464 11994282 11741956
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
JUN CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16393119 21135252 8917510 17166846 19622016 11402335 20220142 22853846 17670745 10567390 17496887 19499154 9878062 21474819 17278098 15282324 15467760 15994313 14672732 15574422 22550166 10066798 17637753 20482821 15574764 11745411 11410592 18084253 20037604 12794082 10790372 16860316 24190040 17501623 17477349 19435822 10500157 11432833
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
STAT3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16510571 19880237 17997399 15469392 16651438 21163886 22566696 16912181 22349830 16384639 12147685 21344490 20160059 19506034 20332458 23329648 11114718 17761947 22218594 15994929 21172343 18988190 18177723 24499623 21435102 19926637 18184402 17344214 22313388 23950841
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
JUN CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
RBX1 CISH â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
RBX1 CISH â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
STAT1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15695802 10848577 9773981 8848048 9037008 16481475 15894584 8986769
CREBBP STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509556 15695802 11574547 10454341
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
CREBBP STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17923090 28707474 10464260 8848048
CXCL12 CXCR4 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
HGF CXCL12 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
CXCL12 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24023874 10233851 10699158 11859124 22633458 18648536 18448868 8752280 30476826 12714578 16725153 9712844 8752281 9551924 21757744 19837984 25495026 26582643 16626895
STAT3 CXCR4 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
CXCR4 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23109003 11406370 12495636 16189514 17169327 10506573
DOK4 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12730241 23331499
EBI3 IL27RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12121660
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
TGFA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 21722395 28988771 25402006 23155381 3018723 23331499 16585207 10209155 24658140 10775655 31980649 12297049 8663070 12648464 27635238
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
JAK2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17389395 10635327 17081983 10358079 16273093 16799092 18691976 10459005 9363897 15284024 23838182 17016520 18669648 15302935
PTPN11 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 28065597 9756944 7588774 16273093 14560030 9642214 8197172 15618223 12270932 7673163 12582165 10411909 16729043 11223155 12577067
SOCS5 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15590694 15695332
PTPN6 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 9038217 9287352 7673163 7518460 9733788
EGFR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23956138 12070153 20145033 14967450 20032199 21573184 25402006 10358079 23894143 14966128 24135280 25241761 14963038 24189400 15657067 24658140 15485908 15950906 18258752 31980649 9756944 22693070 12873986 15951569 15284024
EGFR PTPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 25796184 31980649 8621392 12573287 18253097 11106648 11506178 24658140 7540771 9050838 9355745 15982634 25402006 10889023 7693694 8999839
EGFR STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 23956138 12070153 11839738 10918587 11447289 11997436 14967450 25402006 12040186 24797263 15173823 7543024 15322115 10358079 6321473 11294897 7690989 10982844 19568798 12637327 14585353 15199124 17496910 11438544 10748192 24658140 7657660 12817007 31980649 22693070 9355737 19615955 11152457 15284024 15567848 7592750 16488589
IRF1 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7543195 8622878 9333018
MAPK1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404396 9528799
EIF2AK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23597922 9135145 11278865 16516295 10637230
STAT1 EP300 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 10918613 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15265520 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509556 15145939 10454341
RBX1 FBXW7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15546612 18094723 11585921 11461910 11565034
FBXW7 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14739463 28036276 18930588 16023596
FBXW7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15498494 17145710 32047362 28007894 31569395 33821962 20399964 20970423 17157259 16023596 20852628 15103331 15150404
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN PTPN11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
FYN IFNG â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10591186 10648627 12218089 12731048 16286920 19290918 19909365 20814939 20819927 21378271 22437870 22683124 22863785 24440149 27192565 28900677 9738502
FYN PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10212213 11157475 16713569
STAT3 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14647442 18835816 16407846 11278729 23954444 17967179 12168776
HLA-E PTPN6 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10358164 11015446 11062502 12731048 15120186 15536084 22464172 2731048 8478617 9485206 9486650 9655483
HLA-E PTPN11 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10358164 11015446 11062502 12731048 15120186 15536084 22464172 2731048 8478617 9485206 9486650 9655483
IRF1 HLA-E â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9858567 8990383 14530341 11777545
STAT1 HLA-E â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8702722 19122651 11137213 9858567 17579067
STAT1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9880553 21430289 12940076 10440232
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
IRF9 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20403236 19351818 21056555 20137113
STAT2 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20403236 19351818 21056555 20137113
IRF1 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19351818 21056555 20137113
STAT1 IFIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21056555 17050680 17933493
IFNAR2 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNB1 IFNAR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
TYK2 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR1 JAK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
JAK1 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9677371 8524272 24704786 14647450 7526154 16551269 21949722 23223197 16189514 9121453 8702790 9461596 8605876 7559568 12220192 21994561 15337770 8700538 20937132 8628273 18166147 95059042 9733772 10523853
IFNB1 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 8181059 1834641 10049744 7592797 7623815 11278538 18988627 29311663 112785381834641
PTPN6 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9029147 8524272 16189514
IFNAR1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8943354 18508557 8232552 17351669 8524272 7526154 9334213 23331499 10542297 11694501 10982844 15449939 15312780 8702790 8621447 17969444 8605876 10022928 15120645 16171819 29145629 8197134 16987978 24243840
TYK2 IFNAR2 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNB1 IFNAR2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
JAK1 IFNAR2 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 IFNAR2 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IFNAR2 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNB1 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8181059 10395669 7623815 11278538 1127853810395660
IRF9 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17923090 18456457
IFNAR2 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12220192 17923090 11786546 9121453 18456457
IFNAR2 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 12960323 12040185 18988627
IFNAR2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9334213 23331499 7988557 12133952 23180781 16710296 18988627
IFNB1 JAK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
IFNB1 STAT2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
IFNB1 TYK2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
JUN IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9660935 18035482 22065573 10848607 20048166 22083261 17376932
IRF7 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 22547704 24532789 12604599 15355347 16186222 12915551 16014964 22065573 19176627 23906644 17785777 22698399 17236232 9877175 10938111 11303025 19557165 21994549 10848607 20637800 19349300 14729983 10692430 20581830 11846976 20483755 12821121 19570869
IRF1 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 22547704 11846971 1371248 17073600 1431317 18575764 7630638 12077266 8035474 17785777 19628072 10702232 22358638 1630448 11303025 9315689 10848607 1472868 8106512 9446577 2911367 11888675 8021262 15494505 9707562 1793735 9422515 3409321 9649118
STAT1 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 9325014 18035482 19096445 17374731 22479354 24478085 15194680 16020513 10321980
IFNB1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23933255 22816309 22194884 17488182 12068083 25885435 26353965 25892232 19174562
JAK1 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG JAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16467876 7617032 7673114 12438563 10986460 7615558 1396683 8550631
JAK2 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
STAT4 IFNG â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10807786 10961885 11449378 12372421 8683106 8700208 9715265
STAT3 IFNG â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 10347215 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 19380816 20093776 20237412 20406969 20581311 21115385 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
IFNG STAT1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
SOCS1 IFNG â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
PTPN6 IFNG â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
PTPN11 IFNG â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
IFNG STAT1 â—¼   DOWN_REGULATES ✅ - 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
STAT4 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12759422 12902482 14734615 19359411 23761633 15251440 20620946 11449378 12594853 12893768 10097133 20574006 25589075 19710469 11801649 26123499 15522880 9558063 9642277 16717115 24415943 17110450 16301617
JUN IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20006311 22123848 14734615 15187132 11943142 20304822 17556653 1314139 17105733 22413812 19265145 11801649 16713974 7759501 12836278 15522880 12626576 9558063 8756632 18641343 22351517
STAT6 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17878383 10626890 7635985 10201928 16621996 10528163 10982806 24968940 22078635 9548487
STAT1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759422 14735146 26170288 8823363 1833631 8647290 7619083 11416037 12130529 16162660 21178011 9218597 12493643 17283162 15217838 10830295 24200694 7957928 19476491 9271410 19262492 7565811 9880553 17878383 9748323 21039465 17016440 10881178 21530491 17270146 12052885 15055356 10201928 18616672 13678429 19124156 9491997 24478085 8509377 8990168 12893768 16380218 23740952 17105733 16195385 23419754 19935876 7796811 17558024 19929594 10713330 23645984 9548487 11390994 12223098 15931263 17689680 18802113 18787082 10440232 20004484 10373559 10585866 10707961 12403783 23582260 10982806 9059994 16785492 22767256
IFNG STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 29796172 23285134 18566411 28430601 28143527 24366643 24608040 17947699 25950470 19846878 27378243 18950705 27570112 15051500 17986321 26467650 23657944 20087684 9649436 22823229 14517275 22178447 22425562 23352233 23562842 28445952 11960596 17997851 24443556 26934444 24777831 11972023 12725866 26113305 22162832 29925830 10707961 23840250 25753288 9454765
JUN IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8206951 19920132 19103645 8439327
IRF1 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14568984 16824573 22904313 15240709 19164128 15489234 16219795 15871905 12517966 16622221
STAT1 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19029990 19164128 21987655 20709027
JAK1 IL21 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
STAT1 IL21 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
STAT4 IL21 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
STAT3 IL21 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
JAK1 IL21 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
IL21 STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
IL21 STAT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
STAT3 IL21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26170288 18209077 17884812 20493732 15178704
IL27 IL27RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 14764690 12121660 18988627 17318299
IRF1 IL27 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24214980 20083668 17548596 17684041 26900987 17227910 20435892 17985330
TYK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
PTPN11 IL6 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 27557510 9751747
JAK1 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JUN IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 26513016 10542237 21069809 15389813 15158360 20225236 12667961 20371366 20511231 20862675 8453101 10202034 18502099 10037779 8830832 19687301 21098092 25567680 20351184 17341596 11120852 21312239 24676671
IRF1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7509445 7499267 24012417 9394833 26206900
STAT1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8683127 24242046 23675777 19703987 7619083 18616672 24012417 20693420
STAT3 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22927445 22363173 19797626 22547075 18765795 18616672 23954444 20493732 19751774 22105366 10391682 24315995 20930550
IL6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 26291658 30185178 20185553 28222632 11322950 30143645 27074565 28687744 21538419 16278387 28128332 24496235 26166037 21625597 20371721 25750173 29330478 19962667 26010889 24513872 29702530 25881314 24078775 27866206 24619648 27840174 19380824 24661007 11728826 21619877 11056211 17142955 26417930 29270528 18611949 25452693 27795451 16520748 26843613 29807795 21442031 26893580 26061710
IL6 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 14557255 19715447 3136546 12829785 18775332 7744001 8293462 15895091 11251120 2788034 1995637
JAK2 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
JAK1 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
SOCS3 IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10777583 30591653 12403768 24710148 19620279 23454976 10946280
IL6ST STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12040451 12361954 8272872 18060032
IL6ST JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7896787 23331499 11468294 9388212 21220115 24710148 11742534 23663276 12487370
IL6ST JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 7896787 8174677 9716487
IL6ST PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9632795 12040451 12403768 9195977 8978300 10946280
IL6ST TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9388212 23331499 10929036
STAT1 IRF1 â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
IRF1 SOCS1 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11399519 11875494 12417340 12433365 15644117 16127449 16597464 17260466 17689680 18345002 21097505 22461508 23390297 6357187 8871614
IRF1 MYC â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11399519 11875494 12417340 12433365 15644117 16127449 16597464 17260466 17689680 18345002 21097505 22461508 23390297 6357187 8871614
STAT2 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8621447 8647845 9218597
STAT3 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10068671 8647845 9325164 8168491 21723864
STAT1 IRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 10528163 9218597 10068671 18694960 11752148 17270146 12077266 20825659 24478085 11694349 9307237 8621447 18401423 9806359 22002246 10764778 16140971 19122651 18497060 7678055 8647845 10666420 8168491 9259325 21200019 17558387
IRF1 SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10820262 19482358 20644166
STAT1 IRF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24012417 16512786 10764778 17918184
STAT1 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22951020 11877397 16628196 22252317 12768031 15767254 15664995
STAT2 IRF9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 29145629 7537377 9242679 23331499 8621447 24065129 17923090 21903422 15978943 8943351 12590259 17351669 21178011 21268015
STAT1 IRF9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 29145629 7537377 9242679 23331499 8621447 24065129 17923090 8943351 12590259 17351669
JAK1 PLAU â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
JAK1 TYK2 â—¼   PHYSICAL_INTERACTION 85.0 1.0 ACSN 10433356 10485906 10542212 10623821 11160275 11207245 11306493 11371360 11698286 11867689 11870632 11875494 11964292 12223527 12401408 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 14764699 15099563 15282297 15356132 15573129 15579430 15864272 16200688 16243976 16413922 16424049 16713974 17404308 17485448 17513775 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21097505 21115385 21191065 21220452 21469115 21840487 21930765 21930769 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545
JAK1 JAK2 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 JAK2 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 TYK2 â—¼   SHARES_COMPLEX 85.0 1.0 ACSN 10433356 10485906 10542212 10623821 11160275 11207245 11306493 11371360 11698286 11867689 11870632 11875494 11964292 12223527 12401408 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 14764699 15099563 15282297 15356132 15573129 15579430 15864272 16200688 16243976 16413922 16424049 16713974 17404308 17485448 17513775 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21097505 21115385 21191065 21220452 21469115 21840487 21930765 21930769 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545
JAK1 PLAU â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
JAK1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
JAK1 STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
JAK1 STAT4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
JAK1 STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
SOCS1 JAK1 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
SOCS1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 10950967 12223527 10485906 26192618 10707961 12193701 18988627 10201892 10856136 21469115 23663276 11133764 23124025 12811837 9202126
JAK3 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11641425 19901323 20135364 17259970 12207328 10825200 11909529 15659558 12559972 9553136
PTPN6 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 9520455 23180781 9852037 14624462 8524272 7629131
JAK1 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8702790 19901323 7504784 7589562 15659558 30029643
JAK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 121.0 1.0 Omnipath 18691551 20169197 19901323 12626585 12759422 15805299 10918587 9305919 15261459 21420464 8272872 10851062 12093291 17878297 12626508 12351624 12040185 16497976 15592455 20966397 8662928 18941194 17389395 23331499 11306517 8756628 12576423 11350938 12244150 18669613 7796300 11294897 24710148 11163236 11722592 11418623 8085155 12244095 21690253 14764663 9535918 21098725 9083098 8662591 22905257 14565860 27774606 8626374 19723038 29145629 26260587 9566874 24501689 25297818 9651359 11940572 11429593 11564763 12517932 14551213 8662795 19535621 23124025 18389480 15284024 11706020 11850821 17016520 9582023 17595657
JAK1 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 8790359 21071413 8995399 12270932 12403768 9794795 11036942
JAK1 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 29145629 23331499 10542297 24243840 8197134 10022928 7532278 18508557 16987978 8232552 9020188 12040185 8605876 18988627 10982844 25386349
JAK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 132.0 1.0 Omnipath 35317858 11839738 10918587 15261459 34950606 11306517 8756628 12244150 8156998 9535918 10748192 7657660 12817007 23257612 27774606 25297818 22306691 8631301 7510216 14963018 15284024 24243840 7592750 10851062 11823427 23331499 7532278 11418623 11722592 18988627 12637327 27387064 8662591 10022928 19088846 32953130 7796299 7504784 23124025 19787091 24058793 20169197 7543024 15322115 18941194 19534553 15978943 14978237 11294897 14764663 21429244 14565860 34228987 25386349 18989459 34521819 9020188 19535621 10982844 21576360 12759422 18508557 8232552 12093291 12040185 20006573 8662795 7690989 20087684 11438544 20035788 11972023 29145629 9355737 11152457 12517932 18389480
JAK1 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9852261 23331499 9045682 22661199 22000020 10856136 23124025
JAK1 SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25682267 10950967 16459330 10707961 10373548
JAK2 TYK2 â—¼   PHYSICAL_INTERACTION 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 TYK2 â—¼   SHARES_COMPLEX 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 STAT6 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 STAT4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
JAK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
SOCS1 JAK2 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
PTPN1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23331499 18988627 15780598 15821101 12748279 11694501 11970899 11970898 21806020
SOCS3 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10882725 10421843 23331499 10514492 19543316 21071413 29752723 10551777 24438103 24354892 11314018 15514089 24600449 22342841 18988627 9344848
SOCS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10421843 23331499 21071413 10455112 14522994 10064597 28258213 19287004 18508766 11314018 18988627 11971965 11713228 10975987 9202126 9344848
PTPN6 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8943354 21071413 10772872 15983048 18988627
JAK2 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9852261 23331499 18852293 22992805
JAK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 81.0 1.0 Omnipath 11839738 10918587 7888666 20353823 7543024 15322115 25950470 23331499 21071413 14978237 11294897 7690989 7504785 18988627 12637327 25535282 11438544 21576360 10748192 7657660 12817007 14984365 7504784 21207025 9355737 11152457 7615558 19834108 15284024 10982844 7592750 19787091
JAK2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8912646 23331499 21071413 7559603 8995399 9794795
JAK2 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 16324152
JAK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 167.0 1.0 Omnipath 10918587 8272872 16319070 18718905 15592455 34066153 23166634 33986510 17389395 29162862 29449694 33512408 21098725 9083098 17565041 27748760 27344175 34031055 29290793 21285325 33846242 33774038 9566874 25962054 20826784 14551213 26188635 26008966 15284024 26175413 21481791 33774344 26307676 9305919 10925297 15615703 12626508 16497976 32087696 16469875 31914141 23331499 11350938 28978186 16306356 33824475 18988627 17401459 19147545 15151905 12637586 34433042 8626374 15950906 27181202 24793791 20455003 21575192 32094172 15322111 17016520 34247191 19901323 12626585 27086926 21166956 23906537 31976162 9211920 12576423 22306293 10207096 12075083 11294897 26787900 12244095 14701810 33909625 11803465 17360477 28827891 33820781 19159681 18939995 11445068 27941883 11429593 30054295 26675255 11850821 9582023 34067421 34707127 15786731 25986861 27351213 34118143 15077188 26699492 12595539 21071413 18498667 22153071 15156153 33513694 25915428 11940572 12529382 18525315 24501689 33839684 24316223 19834108 9575217
STAT3 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
STAT6 JAK3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
STAT1 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
JAK3 STAT4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
PTPN6 JAK3 â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 18097461 15317731 16825495 19459784 16871283
PTPN6 JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9520455 18988627 11021818
JAK3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 23109003 11406370 12495636 17277783 9535918
JAK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10037026 23109003 11406370 12495636 16189514 12207328 10825200 12934099 18988627 30029643
JAK3 SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15385932 10373548
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
JUN SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11440364 12390531 19887897 19288028 15069077 22926518 10591684 11223948 12905745 14592829 16105028 17890327 21969564 8917435 8342330 19088796 20351105
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
KPNA1 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11032817 26491019 10523667 26496610 9922449 9102465 17596301
LCK PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
LCK PTPN11 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
MAPK1 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 8506364 7499846 8618896 15967991 8226850 8626561
LCK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11404481 9484840 9344858 18070987 10815799 16189514 10825200 25814554
LCK PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 23071622 8692915 16231973 23109003 14699166 19167335 12459785 12468540 11294838 10574931 7512963 16497976 16189514 14757045 8114715 10488096
LCK STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11839738 10918587 11438544 11152457 9355737 10748192 11294897 7657660 7690989 12817007 12637327 10982844 7592750 7543024 15322115
LCK SOCS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12783885 15173187 16352613
MAPK1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 RCAN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 18039929 19541618 21965663 24751678 19565474 15547943 12063245 12738796 11226259
MAPK1 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12223490 18220336 15241487 25324174 16543145 18676833
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
STAT3 MCL1 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10347215 11160159 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18208354 18776941 19380816 19808698 20093776 20237412 20406969 20581311 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 MCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15805299 19523441 15184887 15469392 16317687 11160159 18790750 16432172 22313388 16048438 20654581 22465052 17951530 17880940 19595668
MED14 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12509459
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC STAT6 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
MYC SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12695333 18414489
MYC PIAS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21811581 22053792 12545156 17471507
MYC TRRAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17848523 23775087 11511535 20194507
TRRAP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 17353931 11511539 12660246 20194507 9708738
PIM1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25749412 28505071 25280219 27775704 18438430 29472550
PTPN6 PDCD1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PDCD1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PDCD1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN6 PDCD1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
STAT2 PDCD1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 PDCD1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
PIAS1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11709556 29145629 23331499 12171910 25241761 14699505 12855578 11257227 18566411 17371985 23663276 9724754 10805787 18988627 19136629 18031232
PIAS2 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12716907 16189514
PIAS3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 11709556 21988832 23331499 12804609 9388184 18037959 15138572 11429412 11266437 20516148 9724754 16189514 19569236
PIAS4 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23331499 11248056
STAT3 PIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10068671 18426800 17717068 22273698
SERPINE1 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22449964 2544876 2161846 21199867 3090045 9184208
PTPN1 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 29145629 23331499 15780598 11694501 16189514 12748279
PTPN1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15821101 23331499 11970898
PTPN11 PTPN6 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PTPN6 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 STAT1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10358138 11447289 11572860 12138178 12270932 12707331 15240681 15699106 15713798 19833085 9751747
SOCS3 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12403768 17138568 11356008 10777583
PTPN11 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10409724 23331499 18508557 12040451 16189514 11594781
PTPN11 SIRPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8943344 18450421 18233962 8910355 12483539 9062191 18471880 11036942
PTPN11 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 18508557 12270932 18832710 18988627
PTPN6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 12176909 12773515 12917349 15240681 15713798 22513334 22952938 25355530 26667266 27474009 8976179 8986721 9765283
PTPN6 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8780698 7629131 8524272 16189514
PTPN6 SIRPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 8943344 10660620 17954568 18233962 16920950 9632768 16189514 10660565 14662855
PTPN6 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12459556 12791978
SMARCA4 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 12917342 23540691 9891079 28420882
STAT1 SOCS1 â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
SOCS1 STAT6 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
STAT6 SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21828071 18342537 15199062 17093501
STAT1 SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12438448 10820262 12193701 19482358 24963279
STAT3 SOCS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18843197 14630083 16432158 20003295 20357037 10809230
STAT3 SOCS3 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT1 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19122651 15339920 10359822 19115200 19643666 14742442 17091494 12639901 17558387
STAT3 SOCS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18489773 22179221 15184887 21994466 20032196 12565872 11682619 23782265 22943202 19628067 23335796 12639901 18571793 23104276 16293640 23027374 22739025 21098664 11788008 18237746 19535626 23303450 20357037 16783372 22575502 16709613 14688368 19332118 23439558 10359822 19910459 19759305 11159537 16300827 16718380
STAT1 STAT2 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 STAT2 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
TYK2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
STAT1 STAT3 â—¼   DOWN_REGULATES ✅ - 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
STAT1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19122651 17558387 22693070
STAT3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 25609649 8662591 12070153 31462771 25241761 11722592 8710878 9794795 23268184 15284024 16189514 9535918 11594781
STAT2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10490982 8621447 24065129 17923090 15978943 1502203 10446176 9724754 14722125 21178011 15825084 21268015 12048190 8605877
TYK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 11839738 10918587 15261459 8232552 7543024 15322115 23331499 8780896 10435617 24243840 11294897 7690989 14764663 18988627 12637327 11438544 10748192 14565860 7657660 12817007 23257612 29145629 9355737 11152457 23124025 18389480 10982844 7592750
TYK2 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 8943354 18508557 8232552 17351669 12040185 7526154 9334213 23331499 10542297 24243840 23223197 11694501 15449939 18988627 15312780 8702790 8621447 17969444 8605876 10022928 32953130 21994561 1638633 16171819 29145629 18989459 34521819 8197134 16987978 10982844 8605877
TYK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29145629 21098725 12626585 10542297 23331499 15261459 8662928 30910759 23673666 14565860 12023369 30029643 14764663 18389480 23124025 25516297
TYK2 STAT4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
TYK2 STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722