PHLPP1
|
AKT1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17386267
15808505
|
AKT1
|
PHLPP2
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17386267
15808505
|
AKT1
|
USP4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22706160
|
FZR1
|
ANAPC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10500174
|
ANAPC1
|
FZR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10500174
|
BRCA1
|
KPNA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5221252
8955125
|
EZH2
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
23624935
21406404
|
TP53BP1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15970701
21914189
|
FANCD2
|
BRCA1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
11239454
5213674
|
KLHDC2
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
EZH2
|
PTEN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
24719098
22956625
|
SIX1
|
EZR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16488997
|
HSPA9
|
SHPRH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
HSPA9
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSPA9
|
RIPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
KPNB1
|
SNAI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
RPS18
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
UBC
|
SNAI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7718905
20385133
|
SYNCRIP
|
TOR1AIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
UBC
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18636086
6804508
|
TP53BP1
|
UBE2K
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RAD18
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
BCR
|
KIT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
8757502
25241761
|
BRCA1
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
25184681
29656893
23901102
|
RAD18
|
FANCD2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.84
|
0.83
|
PKG
|
28854368
|
AKT1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
BRCA1
|
FANCD2
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
12485996
|
PHLPP2
|
WDR48
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
PCNA
|
ATAD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
26496610
20147293
|
BRCA1
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
23624935
25531315
|
UBC
|
USP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
842.0
|
0.84
|
STRING
|
36370105
|
FANCI
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
843.0
|
0.84
|
STRING
|
36370105
|
RPS16
|
RPS4X
|
â—¼ CORRELATES
|
|
+
|
0.84
|
0.84
|
CCLE
|
31978347
|
TP53BP1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
AKT1
|
PTEN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
852.0
|
0.85
|
STRING
|
36370105
|
RAD18
|
PCNA
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.86
|
0.86
|
Signor
|
19706603
|
PCNA
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
RAD51AP1
|
WDR48
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
ATAD5
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
RAD51
|
RAD51AP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
PCNA
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
DSG1
|
DSC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19136012
24981860
9606214
|
PKP1
|
DSC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
24981860
14673151
|
PKP1
|
DSG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19136012
24981860
9606214
|
EZH2
|
SNAI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
24903147
18519590
21685935
|
RAD51
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19396164
25893307
|
RAD18
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
RIPK1
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
32296183
8612133
|
BRCA2
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
RPS16
|
RPS18
|
â—¼ CORRELATES
|
|
+
|
0.88
|
0.88
|
CCLE
|
31978347
|
RPS18
|
RPS4X
|
â—¼ CORRELATES
|
|
+
|
0.88
|
0.88
|
CCLE
|
31978347
|
RAD18
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21967848
28924044
21227930
20675655
32701997
21858012
20064529
28831681
33508099
17108083
18363965
23345618
26170230
17720710
24958773
15359278
31873223
18245774
30700555
31887036
30563767
20600238
22904075
31160570
27377895
|
TRAF3
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22792062
32779804
20174559
22908223
19380580
33187908
24763515
24622840
27135603
23308279
29125880
22079989
33411856
33372174
34084167
32324863
33608556
31404116
23717208
23986588
28049150
26928339
29920243
17991829
22330071
|
RAD51
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11498787
31270457
19369211
14636569
24085845
29656893
28319063
25659039
34408138
31009828
9774970
16713569
25499220
19766185
17302439
9008167
28976962
|
BRCA2
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
14499622
25652403
17664283
19369211
14636569
24085845
29656893
34408138
11477095
9774970
16713569
21135251
25184681
|
EZH2
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19079346
20574448
|
BRCA1
|
RAD51
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16713569
9774970
9008167
|
SHPRH
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18719106
17130289
17108083
|
RPA2
|
RPA3
|
â—¼ CORRELATES
|
|
+
|
0.9
|
0.9
|
CCLE
|
31978347
|
RPA1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
RPA3
|
RPA2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
24126761
|
CUL1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
925.0
|
0.92
|
STRING
|
36370105
|
KPNA3
|
KPNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
929.0
|
0.92
|
STRING
|
36370105
|
H2AFX
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
TBK1
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
FANCD2
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
942.0
|
0.94
|
STRING
|
36370105
|
UBC
|
WDR48
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
KPNA1
|
KPNB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
RAD51
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
949.0
|
0.94
|
STRING
|
36370105
|
RAD18
|
TP53BP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.98
|
0.97
|
PKG
|
28854368
|
CDK5
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
980.0
|
0.98
|
STRING
|
36370105
|
RAD51
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
5219969
17541404
|
PCNA
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
RPA1
|
RPA3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
RAD18
|
USP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.99
|
0.98
|
PKG
|
28854368
|
PCNA
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
UBC
|
UBE2K
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
USP1
|
WDR48
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
RPA1
|
RPA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
RPS16
|
RPS18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
RPS18
|
RPS4X
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
RAD18
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
RPS16
|
RPS4X
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
ANAPC1
|
FZR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
0.99
|
STRING
|
36370105
|
RPA2
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
37.0
|
1.0
|
ACSN
|
11756412
11900249
12648680
12930902
14624239
14726013
15189466
15459660
15703371
16697054
17116885
17296725
17582221
17652783
17884153
18087292
18196958
18584027
18677104
18809224
19258535
1974050
19772495
19793801
19809470
19847258
20211143
20227374
20478261
21282463
21376743
22021614
22743550
23414611
24050180
8264637
8978692
|
PCNA
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
H2AFX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
RPA2
|
PCNA
|
â—¼ SHARES_COMPLEX
|
|
|
37.0
|
1.0
|
ACSN
|
11756412
11900249
12648680
12930902
14624239
14726013
15189466
15459660
15703371
16697054
17116885
17296725
17582221
17652783
17884153
18087292
18196958
18584027
18677104
18809224
19258535
1974050
19772495
19793801
19809470
19847258
20211143
20227374
20478261
21282463
21376743
22021614
22743550
23414611
24050180
8264637
8978692
|
PCNA
|
BRCA2
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
H2AFX
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
BRCA1
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
USP1
|
PCNA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
RAD18
|
PCNA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10884424
15280666
15688063
16611994
16824193
17652783
18157158
18196958
18363965
18498753
19013543
19258535
19396164
20129063
20675655
|
RAD18
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
18363965
19706603
17652783
18196958
18498753
20129063
21227930
10884424
19013543
18157158
15280666
19258535
16611994
19396164
20675655
|
SHPRH
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
19706603
17652783
18196958
19851286
16789823
18719106
18525240
18647995
18157158
10880451
19258535
16224103
20675655
16518696
|
USP1
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
19264559
35324534
19686080
18082604
23589330
20353596
19622404
19075014
16531995
18082605
19217432
18931676
33619839
|
AKT1
|
CUL1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
AKT1
|
CUL1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
PTEN
|
AKT1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
22.0
|
1.0
|
ACSN
|
10753747
11747822
12040186
15721744
16288286
16982858
17218262
17409395
19440036
19847259
19945467
20609352
21084277
22179046
22465479
23732914
24030100
24254977
25364523
26597054
27328425
27572739
|
PHLPP1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
18511290
15899889
20576936
19797085
17386267
15808505
19261608
|
TBK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21329883
21464307
21106850
|
PHLPP2
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
18511290
15899889
19797085
17386267
15808505
19261608
|
AKT1
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
22391560
24526064
29864144
34230470
16224021
26517694
|
AKT1
|
PTEN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
19903340
15987703
10790335
20596030
10592173
20605778
10866658
12077256
11035045
16107342
12297295
|
AKT1
|
HSPB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
12740362
11042204
19593530
22983196
17510053
23397142
|
AKT1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
17428466
20832017
20085797
21242970
17570479
10542266
|
BRCA1
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
H2AFX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
H2AFX
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
BRCA2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
TP53BP1
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11042216
11877378
17243194
18087291
19342239
20646866
9748285
|
USP1
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
BRCA1
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12887909
12485996
11239454
25652403
14499622
16713569
|
FANCD2
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
H2AFX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
BRCA2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
H2AFX
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA2
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
55.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
USP1
|
BRCA2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
FANCD2
|
BRCA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
17145710
19861535
15115758
18212739
15199141
10749118
|
BRCA2
|
RAD51
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
87.0
|
1.0
|
Omnipath
|
17145710
21601571
15937124
17541404
11313963
16914443
26145171
21670257
18264088
19303847
25585578
12815053
16793542
21789034
25282148
17515904
9126738
20729859
15703751
21076401
15065660
22293751
19875419
12606939
22116401
12619154
23935068
15800615
33476590
15800651
15671039
11477095
16513631
9811893
10551859
20729832
9523196
14636569
17515903
12442171
9405383
26833090
21399666
19628690
9560268
10373512
14580352
|
CAPNS1
|
FLG
|
â—¼ CLEAVAGE
|
✅
|
|
4.0
|
1.0
|
Reactome
|
21997417
20179351
17515931
23629652
|
CDK5
|
USP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
12556884
16332722
16858402
17303408
19151707
20724832
21727086
21922195
23589330
23850759
|
CDK5
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12769842
16510591
|
CDK5
|
NFAT5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21209322
|
SNAI1
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15465827
17018611
17563753
21234400
21577210
21685935
22514743
22796940
|
SNAI1
|
EZH2
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15465827
17018611
17563753
21234400
21577210
21685935
22514743
22796940
|
FANCD2
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
H2AFX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
64.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
H2AFX
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCD2
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
66.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14614141
14624239
14726013
15242590
15375219
15377654
15459660
15485915
15703371
16337601
16337602
16697054
16713580
16818604
17303408
17349954
17965729
18082604
18082605
18085520
18087292
18448394
18472307
18543256
18584027
18809224
18931676
18995830
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20064462
20173781
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
USP1
|
FANCD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
USP1
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
19264559
19686080
18082604
23589330
36170365
19622404
19075014
16633336
18082605
19217432
18931676
15694335
|
FANCI
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21719678
22855611
24451376
17460694
27773793
20603015
25168188
19561358
18931676
24623813
|
WDR48
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
19264559
19686080
18082604
23589330
19622404
19075014
18082605
19217432
18931676
|
H2AFX
|
FANCI
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCI
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
H2AFX
|
FANCI
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
FANCI
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
USP1
|
FANCI
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
USP1
|
FANCI
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
19264559
19686080
18082604
23589330
17488615
19622404
19075014
18082605
18985065
19217432
18931676
|
WDR48
|
FANCI
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
19264559
19686080
18082604
23589330
35703356
19622404
19075014
18082605
19217432
18931676
|
H2AFX
|
RAD51
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
H2AFX
|
RAD51
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
USP1
|
H2AFX
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
KPNA1
|
KPNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11032817
26491019
10523667
26496610
9922449
9102465
17596301
|
PTEN
|
RAD51
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10753747
11747822
12040186
15721744
16288286
16982858
17218252
17218262
18716620
19847259
22179046
22465479
23732914
24254977
25364523
|
SNAI1
|
PTEN
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
66.0
|
1.0
|
ACSN
|
10048576
11283614
11708773
12490555
12545156
12668723
14623871
14673164
15111329
15151915
15155580
15181457
15448698
15459715
16001073
16079281
16232121
16510505
16556862
16617148
16716598
16831886
17018611
17055429
17093497
17403902
17490644
17537911
17550342
17563753
17615296
17671186
18172008
18297062
18832382
19208835
19412634
19564415
19597490
19935649
20027199
20702634
20706219
20713526
20731704
21041997
21051859
21159887
21199805
21317430
21577210
21685935
21883379
2191300
22006115
22286765
22406545
22439866
22514743
22796940
22945800
23140366
23869868
8844971
9157999
9618481
|
RPA3
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17720710
12226657
18342608
20129063
|
RPA2
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17720710
12226657
18342608
20129063
|
RPA1
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17720710
12226657
18342608
20129063
|
USP1
|
RAD51
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
16531995
18082604
18082605
18931676
19075014
19217432
19264559
19622404
19686080
23589330
|
RAD51AP1
|
RAD51
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17145710
21307306
21903585
16920159
9396801
20871616
17996711
|
RPA2
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA3
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA3
|
RPA1
|
â—¼ SHARES_COMPLEX
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA2
|
RPA1
|
â—¼ SHARES_COMPLEX
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA2
|
RPA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA3
|
RPA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA2
|
RPA3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA2
|
RPA3
|
â—¼ SHARES_COMPLEX
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA2
|
RPA3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
TRAF3
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
27135603
15210743
16127453
15210742
16306936
12702806
23986588
22792062
16177806
20389019
17991829
20174559
16858409
23717208
34084167
22330071
17468758
17327220
24622840
|
WDR48
|
USP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
32951278
18082604
34128540
23116119
23463011
|
SHPRH
|
SHPRH
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.0
|
3.99
|
PKG
|
28854368
|
RAD18
|
RAD18
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.39
|
4.38
|
PKG
|
28854368
|
TP53BP1
|
TP53BP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-9.54
|
9.53
|
PKG
|
28854368
|