Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 ATF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
ATF2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11243868 19948881
ATRX H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20211137 20651253
ATRX H3-3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20211137 20651253
CTCF BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20733034
BCL6 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160044 12402037
BCL6 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22422878 19487462
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
JAK2 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213490 11163768
H4C6 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16628214 5218530
EZH2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23624935 21406404
YY1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21666725
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
SMAD3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19768112 15735739
MYC BRD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23792448 22904298
BRD4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32482868
H4C6 BRD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12489984 6546635
BRD7 H3C2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12489984 6546635
BRD7 BHLHE40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TFDP1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14618416
E2F6 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12771133 18319725
CHAF1A CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218806 16826239
CDK2 MCM6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10523313 10373557
CDK2 MCM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10523313 10373557
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
MAPK14 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18806262
E2F6 DDX11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 DDX11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
MYC DDX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
DDX5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18829551
E2F1 HMGA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22389255
E2F1 H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12629508
E2F1 MCM6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10327050
E2F1 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17707233
E2F1 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14990995
E2F1 HIC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19491197 19015639
E2F1 E2F6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16107498
E2F1 CDKN2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22504641 12077144
E2F1 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 MYCN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12438307 18319725
E2F1 MELK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 16144839
E2F1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15867357
E2F1 CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12077144
E2F1 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19491197
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 MUC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1203339109 22869720
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15752709 18064385
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
EP300 H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
EP300 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16374512 11433299
MYC FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20638938 19366810
FOXM1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346 17875680
FOXM1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346
FOXM1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18408007
TP53 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
H3-3B KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
H3C2 KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
H3C14 KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
H4C6 KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
KAT2B H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880483
KAT2B H3-3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 34811519 15616580
MYC KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
SETDB1 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
KDM1A BAHD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A EZH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
RELA KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19208907 23423566
SNAI1 KDM1A â—¼   COLOCALIZATION 2.0 0.8 intact 7903691 20389281
MAPK14 RB1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17380128 5219804
PML MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15273249 16189514
TP53 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15899946
PPARG MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12677008 20300579
MYCN MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17826980
RB1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218170 16374512
PML MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
MDM2 BHLHE40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17347673 5219751
MDM2 MDM4 â—¼   COLOCALIZATION 2.0 0.8 intact 17159902 5219425
MDM2 PML â—¼   COLOCALIZATION 2.0 0.8 intact 5216620 12915590
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
MDM4 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 19521340 7290688
SNAI1 MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12161443 24384091
TP53 MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697347 17308127
AR MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21308711
RELA MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19706766 12210742
YY1 MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12388348 15015602
PPARG MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20484415 15572671
ERG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25277175 20820186
EWSR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8164678 11423975
MYC EZH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21941025 19197161
MYC SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24285714 24362264
HDAC3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22002311 18483244
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
RB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 7838535
E2F6 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12004135
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
MYC TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11139609
MYC DNMT3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15616584 19786833
RELA OGT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6166964 17882263
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
PML STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12506013 16189514
RBBP7 AEBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23110252 15225548
H4C6 RBBP7 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3C2 RBBP7 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3-3B RBBP7 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
RBBP7 H3C14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
RBX1 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15082796 17183061
H3C14 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H3C2 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H3-3B SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H4C6 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H3C2 SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
H3C14 SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
H4C6 SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
H3-3B SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
ESR1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21920899 23658738
SMAD3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
SIRT1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21775285
SIRT1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19270680
SMARCA2 DAB2IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
SMARCA2 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
SMARCA4 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYOD1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17194702 17043109
SMARCA4 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
SMARCA4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11950834 33476981
SMARCC1 SMARCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1459453 19785031
SMARCC1 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AR SMARCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 20610535
SMARCC1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 18581278
NCOA1 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603
SMARCC2 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
H3C2 SNAI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7903691 20389281
SMAD2 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19389392 18618014
SMAD4 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18618014 18832382
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
STAT3 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17386941 31886314
STAT3 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15677471 23874455
STAT3 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 12947115
TP53 STUB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21478269 17666403
SUPT16H MCM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218941 16902406
UCHL1 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 TFDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19196987 0812256106
TP53 CDKN2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
MAX TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7969121 10348347
ZBTB16 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24821728 24821727
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
TP53 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
TP53 ZDHHC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28775165
USP7 TP53 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 5215220 11923872
TP53 BHLHE40 â—¼   COLOCALIZATION 2.0 0.8 intact 17347673 5219751
MYCN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20145147
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17015431
ZMYND11 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7556586 20138174
HDAC3 TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18037959
EWSR1 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
USP7 RELB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
H4C6 YY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YY1 CTCF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9756895
SETDB1 BHLHE40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TLE1 CDKN2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PRDM14 POU5F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20953172
H4C6 HAT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 1114117109 22615379
DNMT1 ASCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15390277 16371653
SMAD4 MYOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PPARG MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16838108 11477074
POU5F1 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21425413 22153073
MYOD1 PJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28067271
SMAD3 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11711431
RB1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21902831 8381715
FLNA SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AKT1 FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15461588 17570479
SMAD4 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD4 RUNX3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16135801 10531362
SMAD4 BTRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14988407
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
SMAD4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
SMAD2 ZMYND11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21836474 21926264
ZBTB16 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD3 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 8308197 22045334
SMAD3 RUNX3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16135801 10531362
WT1 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20842112
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
SMAD3 FOXP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19701891 15367216
BCOR HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10898795
HDAC3 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17694085
AR SIN3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16254079
MCM6 MCM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
MYCN MCM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17826980
MCM6 MCM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
MYCN MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17826980
E2F6 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
MYCN MCM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17826980
MYCN MCM6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17826980
RELA DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23457487 24025864
BTRC RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 9990853
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
CREBBP RELB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12789342
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
RORA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24226095 14687547
EWSR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8552387 12459554
CREBBP H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
CREBBP H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
MRPL41 SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18157088 6492033
SMURF2 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 MRPL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18157088 6492033
ESR1 ITGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489
RUNX3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24042352 22231444
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
WT1 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10470095
AR LATS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15131260 20610535
SETDB1 PPP1R8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PHB2 AEBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NCOA1 ESR1 â—¼   PROXIMITY 2.0 0.8 intact 5222291 17627277
NCOA1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18022353
NCOA1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18022353
H4C6 DNMT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HMGA1 NOP14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
WT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
ESR1 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
EED H3C14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
EED H3C2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
EED H3-3B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
EED H4C6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
ERG AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8388477 22531786
AR RORA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24119295 20610535
AR RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069693 20610535
AR SMYD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 24174655
EZH2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 23239736
RB1 KDM5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22615382 1119836109
RARA MED1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17641689 5220098
DNMT3B DNMT3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20426865 15362956
DNMT3A POU5F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21608077 22867868
DNMT3B EHMT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16371653 17584191
H4C6 EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3C2 EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3-3B EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
EZH2 H3C14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
EWSR1 EZH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19502792 19289832
PJA1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28067271 23688634
PRMT5 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1209814109 23071334
H4C6 PRMT5 â—¼   METHYLATION ✅ 2.0 0.8 intact 1209814109 23071334
KDM2B RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 17296600
BCOR RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 17296600
H4C6 PRMT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18079182 11448779
LCOR EHMT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
EHMT2 H3-3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
H3-3B RBBP4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H4C6 RBBP4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3C2 RBBP4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
RBBP4 H3C14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
E2F6 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 12909625
EWSR1 HMGA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HMGA1 H3C14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HMGA1 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CTCF WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24534946
CTCF DNAJC21 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CTCF RBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21325284
H3-3B SUZ12 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H4C6 SUZ12 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3C2 SUZ12 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
SUZ12 H3C14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
LCOR EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRIM37 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ZBTB16 DNAAF5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
H3C14 H3-3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ZMYND11 H3-3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24590075 24675531
CDK2 MCM3 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 21965652
PCGF1 USP7 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
HIST1H3A HIST3H3 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
HDAC3 KDM1A â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
HIST3H3 PHF19 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
BRCA1 SMAD3 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19768112 15735739
BRD4 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 32416067 20676058 24945803 30428346
SMAD1 DDX5 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18548003
AKT1 MDM2 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
MDM2 AKT1 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
SMURF2 SMAD2 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5217094 15231748
BRD7 SMARCB1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
PBRM1 SMARCA2 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
BRCA1 KDM1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22990118 26831064
BRD7 MYC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20215511 35140242
MYC CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
CDK2 UCHL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21319273 23543736
MDM2 CUL4B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28225217 22032989
CUL4B RBBP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23238014 34026424
TRAF6 DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 25499913
CUL1 DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22474075
EED DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23238014 17041588
ERG EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 28536097
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
FBXW7 STAT3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31843895 28069035
KAT2B KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10373431 24981860
ESR1 KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16260778 31527615
SMAD2 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22995475 15009097 11058129 34576109
SMAD3 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22995475 15009097 11058129 15994459
MCM3 MYC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
MYC RBBP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC PHB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29467282
MYC MCM6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
MYC DNMT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
PML PPARG â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32929351 20211142
PML EZH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17560333 27634302
EZH2 HDAC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23079660 21685935
PPARG RARA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 32929351
AKT1 UCHL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25640309 16027165
PCGF1 BMI1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 26687479
ESR1 CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
ESR1 SUZ12 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31527615 26389696
ESR1 BCOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26487511 31527615
DNMT3A DNMT3B â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
CTBP1 EZH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31041561 27634302
EZH2 EHMT2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27634302 26496610
EZH2 CENPV â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27634302 26496610
EZH2 MKRN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26496610 32460013
LCOR RBBP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
PHF19 RBBP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23104054 27705803
LCOR PHF19 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
LCOR EZH1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
CHAF1B RBBP4 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
ESR1 STUB1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
DNMT3A HIST3H3 â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
ATRX HIST3H3 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
MYC BRD4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29172540 30415952 32416067
BRD4 MED1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19766566 33567268 31239290 20098423 30554943 32416067
SIRT1 EP300 â—¼   DEACETYLATION ✅ - 0.83 0.83 Signor 19047049
MYC EPC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 35140242 30415952 20946988
ESR1 KDM1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 17289570 31527615
KDM1A EZH2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31130994 23455924
SNAI1 MDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20385133 22128911 34040386
PML SMAD3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 15356634
EZH1 RBBP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 27705803 24981860
PHF19 RBBP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23104054 27705803 33961781
RBBP7 KDM5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 24981860
RBBP7 ZBTB2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 33301849 26186194
TRAF6 UCHL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23717208 17353931 32814053
EZH2 SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24981860 27634302 27705803
MAX SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29028833 33961781 25609649
MAX E2F6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27705803 33961781 25609649 24981860 29028833
DNMT3B HIST3H3 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
AEBP2 EZH1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 27705803 24981860
E2F6 EZH2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16565076 15536069
EHMT2 CTBP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 17967884 31041561 16702210 33961781 26186194
CTBP1 BCOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 35016035 26186194
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MCM7 RB1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
DDB1 HIST1H3A â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 CDK2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
KAT2B MDM2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
FOXP3 STAT3 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
BRCA1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25531315 23624935
CDK2 TFDP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 9199321 25852190
EZH2 DDB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23238014 27634302
SUZ12 DDB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23238014 27634302
SNAI1 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28296173 25314079 32494626
MYCN FBXW7 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19111882 27837025
MAPK14 RB1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
BCL11A RBBP7 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
PRAME RBX1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22912744 21822215
TRAF6 USP7 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
EPC1 E2F6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15536069 23082233
EZH2 MYCN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23362253 27728805
NCOA1 ESR1 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 17627277 5222291
ESR1 NCOA1 â—¼   PROXIMITY ✅ 0.84 0.84 mint 17627277 5222291
ESR1 EHMT2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21984853 31527615
ESR1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31527615 17502350
SUZ12 AEBP2 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 24981860
EHMT1 CTBP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 31041561 16702210 33961781 26186194 12700765
HIC1 SIRT1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
SMARCA4 TP53 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DNMT3B EZH2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DDX5 ESR1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
POLR2A SMARCB1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CHAF1A RBBP4 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDK2 MCM3 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HDAC3 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
KAT2B SMAD3 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
DISC1 FBXW7 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDK2 RBL2 â—¼   PHOSPHORYLATION 0.85 0.85 Signor 11157749
CUL4B SIN3A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 25189618
EP300 MCM3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
EP300 MCM4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
EP300 MCM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
FBXW7 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 8399454 23108047
MYC HDAC3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23079660 31155734 22002311 18483244
ESR1 RBBP7 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18577416 23403292 21182205 31527615
LATS2 SNAI1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24157836 21952048
SNAI1 HDAC3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 25314079 21685935
RORA MYOD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9862959 16713569
ESR1 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21182205 19805454 25604459
SMAD4 MAX â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 12551947
SMAD2 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20207742 11555647
SMAD3 RUNX3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10531362 27497248 15138260
HDAC3 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29523594 20026773
MAX TFDP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27705803 33961781 25609649 24981860 29028833
HMGA1 PPARG â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22207709 10428835 18310298 10428834
BMI1 EED â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23238014 24457600
DNMT1 EZH2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
KDM5A RARA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11358960 16713569
RARA ASXL1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19377461 23850490 16606617
RBBP4 SALL4 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SIN3A ZBTB16 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
HIST1H3A PRMT5 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
DDB2 HIST1H3A â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
HIST3H3 SETDB1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
JAK2 BRCA1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 11163768
BRCA1 FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22990118 20305393 16713569 26831064
MCM3 CDK2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15232106 16189514 21965652
CDK2 TP53 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24173284
CUL4B DDX5 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 28225217
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 RUNX3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24229708 15138260
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
MAX KAT2A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10611234 12660246
MDM2 CUL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20708156 24804778
EZH2 RBX1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23238014 26496610
ESR1 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
AKT1 SMAD2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16362038 24412244
HDAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31527615 16469706 14722073 26487511 20348541
RARA AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16417524 23693014
ASXL1 AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 33758188 18624398
ESR1 RARA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9717844 25303530 25604459
RBL2 RBBP4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 33961781 17531812
BRD4 EP300 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
TP53 WT1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
BRD4 ATRX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31239290 30554943 32416067
CUL1 CDK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 9636170 26186194 21145461 23455922
CUL4B SUZ12 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23238014 27634302
KAT2B E2F1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24502362 23001041 35140242 19188449 24112038 15123636
E2F1 KAT2A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11418595 35140242 24502362 20972224
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
GATA4 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18252717 27208796 11481322
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
EP300 NCOA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16713569 10973497 20368990 15688032 14722092 12208951 11113179
CTBP1 KAT2B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15834423 9824164 16122695
KAT2B MYOD1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20364308 9659901 27453350 17964260 10944526 10619020 12887892 17468105
EHMT2 KDM1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26028330 26751641
MYC KDM1A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 32296183 30415952 29467282 23455924
KDM1A CTBP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 17967884 31041561 28947780 20547759 26496610 33961781 26186194 16140033 16079794
MYC EPC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 35140242 30415952 20946988
MYC MCM4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 30415952 29467282
EZH2 RBBP7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 27705803 26496610 33961781 24981860 26186194 27634302 24457600
SUZ12 RBBP7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 27705803 33961781 35016035 26186194 24981860 12435631 27634302 24457600 31281901 20075857
AEBP2 RBBP7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 26186194 27705803
RBBP7 EED â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 27705803 26496610 33961781 24981860 26186194 12435631
SMAD3 MAX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16189514 25241761 12551947
HDAC3 RBBP4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11777905 16189514 11470869
DNMT3B HIST1H3A â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
ESR1 PHB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10938099 24051437 12943695 26052702 17932104 19805454 28555617 10359819 15140878
RARA NCOA1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 5218295 16456540
PHF19 EED â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 23104054 27705803 26496610 33961781 24981860 21143197
LCOR EED â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24981860 26496610 27705803
EZH2 AEBP2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 29348366 26496610 27705803 28068325 33961781 24981860 26186194 27634302 24457600 31281901
LCOR EZH2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24981860 26496610 27705803
PHF19 EZH2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 23104054 27705803 33961781 24981860 27634302 21143197 24457600
SUZ12 PHF19 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 23104054 27705803 33961781 24981860 27634302 24457600
PHF19 EZH1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 27705803 24981860
SUZ12 LCOR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 27705803 33961781 35016035 24981860
KDM1A SNAI1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MDM2 PML â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SMARCC1 SS18 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BRCA1 CREBBP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SMARCC2 SS18 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
RELA RELB â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BRD7 PBRM1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AR STUB1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ESR1 PHB2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ATRX HIST1H3A â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BTRC SNAI1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BCOR KDM2B â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
DDB2 RBX1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PML RARA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RB1 SMARCA4 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
HDAC3 RELA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK1 EZH2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HIST3H3 PBRM1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HIST1H3A KAT2A â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
DNMT1 DNMT3B â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMARCA2 SMARCA4 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BTRC SMAD4 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ATF2 BACH1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 23661758 20102225
CTBP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 16713569 10196224 31636387 11751867
BRCA1 RBL2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 11521194
DDB1 KAT2A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11564863 21987584
CUL1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10559858 11245432
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
EP300 RORA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9862959 16713569
KAT2B RARA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9445475 17475621 14581481
HDAC3 KDM1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23752268 21258344 21670149
MAPK14 TP53 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
STAT3 PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12506013 16189514
PML HDAC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11259576
EZH2 SNAI1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21685935 24903147 18519590
MYOD1 STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12947115 16713569
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
E2F6 BMI1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11171983 16189514 24981860
DNMT1 EED â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16357870 22094255
E2F6 RNF2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MDM2 RB1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
SIRT1 USP22 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HDAC3 YY1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BCOR RNF2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 MYOD1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CHAF1A HIST1H3A â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
MDM4 USP7 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ESR1 MED1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EP300 YY1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
MED1 RARA â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
KAT2A MYC â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP KAT2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
JAK2 STAT3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CTBP1 KDM1A â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
BCOR BCL6 â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 10898795
BCL6 BCOR â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CUL4B DDB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CREBBP SMAD2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RBBP4 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10220405 16713569 26831064
MED1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15208681 16713569
E2F1 CDK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8458319 7969176 9199321 1530885 11245432
CUL4B EZH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23238014 24292684 27634302
DDB1 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22118460 20870715 16473935 15448697 16678110 30349055 33504946 16751180
DDB2 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16260596 28416769 16473935 25628365 26496610 12732143 33961781 30349055 20368362 16751180
SMAD3 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15464984 18548003 19917253
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
FBXW7 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32086376 28522751 21205095 33961781 33504946 31285543 11565034 22388891
KAT2B MYOD1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
KAT2B NCOA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9445475 9296499 9223281
MDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12897156 11178989 16713569 10766163 17545634 31012223
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
RARA PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11050004 1311253 16189514 16713569 16540467 10882117 17560333 18073335 10610177 12935927 20159610
RB1 RBBP7 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
NCOA1 STAT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17471507 11773079 16713569
JAK2 STAT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10925297 11294897 15156153 30413785 15284024 11350938 12626508 12576423 11940572 10918587 12244095 8626374 9211920 19834108 26775640 14551213 27351213 23838182
HIST1H3A SUPT16H â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
DNMT1 EZH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31130994 16357870 22094255 28068325 21378168
KDM5A ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11358960 31527615
AEBP2 RBBP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15225548 29348366 27705803 33961781 24981860
PCGF1 KDM2B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16943429 26687479 25533466 27505670 23395003 29985131 32628469 27705803 22325352 33961781 29502955 24981860
EHMT1 EHMT2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
EHMT2 EHMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21430779 26028330 27705803 21258344 24981860 34588438 28698370
EZH1 RBBP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 27705803 24981860
CTBP1 LCOR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31041561 20211142 12535528 27705803 33961781 35016035 26186194 24722188
H3C2 H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 7219095 19498464
SMARCA2 SS18 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
RBBP4 RBBP7 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
SMARCA4 SS18 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
HIST1H3A KDM1A â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
CDK1 RB1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
SMAD1 SMURF2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
AR NCOA1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMARCB1 SS18 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
STUB1 TP53 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ARID1A SS18 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDK2 RBL2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ATF2 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18638549 15618023
EZH2 ATRX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9499421 25417162 27634302
BRCA1 BACH1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17664283 15208681 16713569 19369211 17525340 15125843 15242590 16391231 25252691 11301010 11877378
SIN3A BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16147992 9765306 9753732
BCOR BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23911289 16713569 15004558 33468080 26496610 18280243 10898795 20807888
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
EP300 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17828269 12402037
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
RBBP7 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11394910 10220405 16713569 11746496
MYC BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12646176 11916966 16713569 20215511 9788437 30415952 14612409
AKT1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21242970 10542266 20085797 19074868
CDK2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 16713569 10373534 9244350 8764100
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
CTCF BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15252835 24725430 19466541
EZH2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19079346 20574448
BRD4 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22509028
MYC BRD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19111069
CDK1 FOXM1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 18285455 19160488 15024056
CDK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17477081 23526763 21840486
RBL2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9891079 17531812 25852190 9472014 33961781 26186194 23602568 10825149 23455922 9188854
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
CDK2 NCOA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10660621 21550420 17570479
CDK2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
DISC1 CEP63 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 90000000 31413325 17043677 12812986
RBX1 CUL4B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 33969670 24292684 12481031 25189618 12609982 26496610 30349055 27113764 29499938 19250909 22038470 34026424 28446751 31973889 23238014 33961781 33504946 30945288 32140073
CUL4B DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19651607 33969670 33357448 28225217 24292684 25189618 21145461 18593899 26496610 16678110 16964240 33536335 27113764 29499938 30898011 28886238 29738775 17392787 29846670 22939629 22038470 34026424 16949367 31911655 28446751 17041588 23238014 31973889 16861906 33961781 30945288 26344197 32140073
CUL4B DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17041588 31973889 18593899 26496610 30923324 33961781 26186194 21145461 30945288 16949367
DDB1 DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22118460 28035050 12050362 24249678 26410533 22822215 28416769 29262658 16473935 18593899 30923324 16678110 16964240 20368362 12812979 19295130 16751180 19109893 17360488 16260596 27203177 17392787 10777491 12151405 32985517 14751237 22039351 17041588 12732143 11564863 9418871 19966799 33961781 26186194 34251884 16949367
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
MYC DDX11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
E2F6 DDX11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12909625
DDX5 PRMT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14631847 28539435 14675539
DDX5 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 33742100 12527917
DDX5 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 25604459 12738788 20308691 11250900 21182205 10409727
EP300 DDX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12527917 20663877
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
E2F1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10914734 20837136
E2F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24502362 17575144 15867357
E2F1 FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21518729 22802261
E2F1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24755270
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
E2F1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15711575 12110166 18319725
E2F1 MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18328430 18319725 14990995
E2F1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19276347 21625432
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 MYOD1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20364308 12665587 20037778 17964260 35140242 10944526 9862959 9001254 8621548
EP300 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 17468099 10944516 14701856 11287611 19596656 32603375 11877444 12040021 10075656 30595551 22787115 12479814
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
YY1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
EP300 ZBTB16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15964811
FBXW7 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27795300 31569395 35140242 15150404 33494392 15498494 28007894 23750012 31638140 17646408 28209614 16023596 17157259 25716680 20970423 23791182 32021252 30606768 32345600 17873522 33821962 31152129 20848231 32047362 22524983 17314511 25720964 31285543 32350066 33086033 15103331
TP53 FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23518350 19366810 12824889
TP53 FBXW7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31346036 12824889
SMARCA4 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19015639
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
HSP90AA1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1406681 18266962
KAT2A KAT2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
KAT2A MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16287840 28628118 10611234 32140074 20691906 35140242 12660246 28205554 17967894
MYC KAT2B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15572685 35140242 12660246
KAT2B MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21209460 21060154 32404984 14769800 12068014 28286521
NCOA1 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12163591 10809234 10777539
KAT2B H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34811519 16096646
SNAI1 KDM1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25639869 20562920 23011797 33961781 26186194 20389281 21300290
AR KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16079795 22052438
RELA MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 MAPK14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11437382 15132979 14570892
MAPK14 H3-3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11278789 10806218 12917630
MYC MCM7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17353931 17314511 29467282 30415952
MYC MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
AR MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
AKT1 MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
MDM4 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10629057 32300648 25512388 21988832 25384516 25809483 17616658 25105592 12874296 31796886 29295817 32075226 20705607 17301054 22493164 25703327 27777309 29523541 27617579 23028042 20473904 22120712 22333590 22902369 22745160 12860999 19432880 21925390 28205554 25659040 19838211 33985974 16055726 25961923 32427989 18566590 22266850 18219319 29057323 10608892 30598450 29524278 25825738 17159902 24813712 31024344 27621617 15604276 29262653 19619542 10218570 28628118 16227609 10827196 12393902 24755078 20724842 34551723 27215386 11606419 20484049 12370303 23671280 26001071 26720344 33961781 12483531 23946421 19683495 26359458
MDM2 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22869143 16713569 12915590 23169665 14507915 19150978 20972456 15195100 12759344
TRIM28 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16107876
MYC MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
YY1 MYC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 18490439 19219071 2191300
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
WT1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15286719 17634147 20842112
RB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7680889 10200487 9671466
MYC RBBP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC HDAC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SNRPB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
PML SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15356634
RBBP4 RBBP7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17255935 27705803 22863883 33961781 24981860 26186194 15451426 22939629 26344197
SIN3A RBBP7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9651585 17255935 27705803 33961781 24981860 26186194 12453419 15451426 11784859
SIRT1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15850715 21633182
USP22 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26049753 32763411 28417539
SMARCC1 SMARCB1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 24421395
AKT1 SMARCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16568092
RELA SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18477483 19538137 17665043
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
TP53 CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16169070 16713569
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
YY1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9238849 21852380
H3C2 UHRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22064703 17673620 22348533
H4C6 UHRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22064703 17673620 22348533
H3-3B UHRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22064703 17673620 22348533
H3C14 UHRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22064703 17673620 22348533
UHRF1 DNMT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20613874 22064703 19798101 33170271 17673620 29691401 19800870 21045206 29268763 33465813 21268065 21745816 24782312 27045799 19943104 17934516 28803780 31322780 27049577 26065575 24368767
BHLHE40 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15975549 22610404 11879638
CSNK2B TLE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CSNK2B DNMT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYOD1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10973962 16901893 21689744
PHB2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15173318
FLNA VAV1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16849481 21277899 27242793
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
AKT1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 23397142
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD4 CTCF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12099698
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
AKT1 SMAD3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 25241761
RARA SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21310893
HDAC3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16528103 18241676
RBBP4 SIN3A â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SIN3A RBBP4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9651585 11118440 9150133 27705803 21258344 33961781 24981860 12943729 12453419 11602581 15451426 9150135
MYCN MCM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17826980
MYCN MCM3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17826980
E2F6 MCM3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12909625
MYCN MCM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17826980
MYCN MCM6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17826980
RELA WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
MED1 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23178929 17704298 10944516 30575522 15604093 19596656 12037571 10037764 30595551 17011503 16554032 9325263 17468099 22070604 15026545 11500849 30651555 11027271 11877444 10935544
PPARG NCOA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23178929 17704298 10944516 15604093 19596656 17312272 10731636 16373399 30595551 17011503 17468099 22070604 15026545 10339548 10347167 9121466 9041124 23975195 20717101 10848596 9744270 17449869 11500849 16713569 11027271 11877444 15888456 17513608 30813326
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
RARA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23321499 16417649 21110951
POU5F1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23041284 20683952
AKT1 DAB2IP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27858941
RARA NCOA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16606617 16713569 17641689 17475621 12665583 9121466 10454579 10760302 21478865 23975195 20338915 17363140 9192892 10082574 16456540 12138096 20543827
NCOA1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20608937 15604093 12738788 11003650 11250900 18451880 11867769 15140878 16282588 11165056 11376110 17627277 14715875 10731636 9259327 17363140 11113179 16606617 12630920 9121466 10760302 26487511 23975195 11682626 12714702 9192902 9192892 23874500 11358671 16713569 11014206 10454579 9773983 12554772 9427757 10598586 10409727 9774463 12574227 16957778
POU5F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22795133 30140294
DNMT1 DNMT3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24423239 16481298 20155458
MED1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18391015 15886699 31527615 10760302 12738788 9653119 10770935 12837248 11867769
ESR1 PRMT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 28539435 18657504 11029009
ESR1 NFIB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26153859 18414489
SUZ12 EED â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 24981860
AEBP2 EED â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15225548 29379173 21078963 29348366 27705803 26496610 33961781 24981860 26186194
AEBP2 SUZ12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15225548 29348366 27705803 33961781 35016035 26186194 24981860 27634302 24457600 31281901 20075857
KDM5A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 30246379 18483221
RARA MED1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19377461 25303530 16713569 17641689 21478865 10760302 9653119
RARA ZBTB16 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24821728 21949697 11106752
WT1 DNMT3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23042785
EZH2 SUZ12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 21135039 21884980 27338022 18931660 28068325 23079660 24469040 19026780 21190999 26496610 26748827 24320048 33849069 35016035 27634302 29669287 18285464 20543829 18453536 31130994 21123648 20123894 24183680 27728805 25470042 12435631 22939629 16224021 23624935 24457600 26344197 20075857 15882624 23684459 31786184 31281901 23238014 26130719 19026781 27705803 22439931 27303043 31631027 24981860 33961781 19734898 31948940 18483221 21378168
BCOR PCGF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16943429 26687479 27505670 27107012 32628469 33468080 26496610 27705803 22325352 33961781 24981860 23523425
E2F6 RBBP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12909625
E2F6 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 16189514 25416956 9501179 20211142 9704927 27705803 33961781 24981860 26186194 26871637 15536069
CTCF SUZ12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18662993 21536749 33196849
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RBBP7 SIN3A â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PHF19 RBBP4 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SMARCC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
HIST1H3A UHRF1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
AEBP2 EED â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
MAX MYCN â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
HIST1H3A SETDB1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
H3C2 CHAF1A â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 7219095 19498464
CHAF1A H3C2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 7219095 19498464
H3C2 CHAF1A â—¼   PROXIMITY ✅ 0.91 0.91 mint 25281560
CREBBP HIST3H3 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
EZH2 EED â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 24981860
KAT2B TP53 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
SMAD3 SMURF2 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
HIST1H3A RBBP4 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
KDM2B RNF2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CHAF1B HIST1H3A â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
HSP90AA1 STUB1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
RB1 RBBP4 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
TP53 USP7 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
PBRM1 SMARCB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SMAD2 SMURF2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
H3C2 CHAF1B â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 7219095 19498464
CHAF1B H3C2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24981860
H3C2 CHAF1B â—¼   PROXIMITY ✅ 0.92 0.92 mint 25281560
MDM2 USP7 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CDK1 HIST1H1A â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
PCGF1 RNF2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
EED RBBP7 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
HIST3H3 KAT2B â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
EP300 HIST1H3A â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
FBXW7 MYC â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EED PHF19 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EZH1 PHF19 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
MDM4 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 15604276 5217417
MDM4 MDM2 â—¼   COLOCALIZATION ✅ 0.93 0.93 mint 17159902 5219425
SMARCC1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
CUL1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 17318178 5219675
CDK2 RB1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
HAT1 RBBP4 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
AEBP2 EZH2 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
E2F6 TFDP1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
HIST1H3A PBRM1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
EZH2 PHF19 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
FOXP3 SMAD3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
EZH2 RBBP7 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
RNF2 PCGF1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 24981860
EZH1 SUZ12 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 19026780 19026781 27705803 33961781 24981860 27634302 24457600 31281901 20075857
DNMT3A HIST1H3A â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
CSNK2B PPP1R8 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATF2 MAPK14 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
BCL11A RBBP4 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
EZH2 RBBP4 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CHAF1A CHAF1B â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
TFDP1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
RBBP7 SUZ12 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
SMARCB1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
SUZ12 EZH2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
EZH2 RBBP4 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 21123648 26496610 27705803 20123894 34518534 28068325 33961781 24981860 27634302 24457600
TFDP1 E2F6 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
ARID1A SMARCC1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ARID1A SMARCA2 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
BRD4 RELA â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR2A SMARCA2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BTRC RBX1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
HIC1 CTBP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 17213307 12052894 16762039 19486893
AKT1 MDM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32450252 25241761 18332867 12145204 19166854 15527798 20856200 11715018 23397142 11504915 11923280 21930127
TP53 MDM4 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7290688 19521340
TP53 MDM4 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7290688 19521340
RBBP4 HAT1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25416956 33961781 26344197 24981860
MCM4 MCM3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16902406 12614612 27621311 33961781 30108253 22939629 26344197
RNF2 BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16710298 5218667
BCOR KDM2B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16943429 26687479 25533466 27505670 26496610 24981860 33722704 29502955
KAT2A USP22 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PBRM1 SMARCC1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
POLR2A SMARCA4 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FBXW7 RBX1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
RB1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5219804 17380128
E2F1 TFDP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31130363 25368385 20211142 28542143 35140242 9780002 8816798 8657117 9199321 19015639 8816502 16360038 15133492 8405995 30867845 8832394 7892279 7739537 9501179 9704927 27705803 22629304 24981860 9464260
FBXW7 CUL1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 28522751 23108047 23322298 28007894 21145461 22388891 29695787 23453757 14603323 22405651 29499133 31285543 25143387 32086376 22524983 11585921 25515538 25720964 26976582 21205095 29103612 33961781 29408378 11565034 32350066
MCM4 MCM7 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12364596 12694531 20808282 8631321 8798650 12207017 9099751 12614612 7601140 10748114 23764002 24299456 15232106 22939629 17296731 10567526 22540012 22863883 27173435 26344197
USP7 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6799761 18566590
USP7 TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5215220 11923872
TP53 USP7 â—¼   DEUBIQUITINATION ✅ 0.97 0.97 mint 5215220 11923872
HDAC3 PPARG â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 12943985 17015477 35140242 24982244 12479814
MCM3 MCM6 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 28514442 16189514 22939629 12614612 26496610 22863883 27621311 33961781 30108253 17296731 26344197
EED RBBP4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15225548 29379173 21078963 27705803 26496610 33961781 24981860 12435631 15385962
EED SUZ12 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 29379173 27338022 19026780 26496610 35016035 27634302 15385962 15225548 18285464 20543829 12435631 31786184 24457600 31281901 20075857 19026781 21078963 27705803 22439931 28320739 33961781 24981860 23280602 18483221
EED EZH2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21135039 9584197 9742080 31948940 29379173 27338022 18931660 28068325 33754075 11158321 9584199 32296183 22897849 17937919 19026780 21190999 26496610 24320048 33849069 27634302 15385962 16314526 29669287 15225548 18285464 10581039 21123648 12435631 31786184 23624935 24457600 20075857 15882624 19026781 21078963 22094255 22439931 28320739 27705803 31527584 24981860 33961781 23280602 26344197
SUZ12 RBBP4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 15225548 27705803 33961781 35016035 24981860 27634302 22939629 24457600 31281901 20075857
PBRM1 SMARCA4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PBRM1 SMARCC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
HAT1 RBBP7 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SMARCA2 SMARCC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EED RBBP4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EED EZH1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EZH1 SUZ12 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
UHRF1 USP7 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CREBBP NCOA1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RB1 TFDP1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SMARCA2 SMARCC1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
BCOR PCGF1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CSNK2B SUPT16H â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
HIST3H3 UHRF1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CREBBP PPARG â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CREBBP HIST1H3A â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
DNMT1 USP7 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
MED1 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
AEBP2 RBBP4 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
PHF19 SUZ12 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
RBBP7 HAT1 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 27705803 33961781 20953179 26186194 24981860 22939629 28143904 26344197
EED EZH1 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 32296183 19026780 9584197 9566901 20211142 19026781 27705803 28320739 33961781 24981860
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
SMARCA2 SMARCB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
KDM2B PCGF1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ARID1A SMARCB1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
HIST1H3A KAT2B â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
AEBP2 SUZ12 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
NCOA1 RARA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
NCOA1 PPARG â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
ESR1 NCOA1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MRPL2 MRPL41 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
E2F1 TFDP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ARID1A SMARCC2 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
MCM3 MCM7 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 17296731 16189514 22939629 26264872 12614612 20808282 8631321 7601140 23993743 27621311 23764002 33961781 30108253 11779870 10464337 9099751 26344197
MCM7 MCM2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 12694531 20808282 8798650 12207017 14681455 9099751 12614612 10748114 23764002 15232106 25963833 30100344 22939629 17296731 10567526 22540012 22863883 33961781 27173435 26186194 16899510 26344197
MCM7 MCM6 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 22939629 12694531 12614612 20808282 16438930 26496610 12207017 23764002 27173435 17296731 9099751 26344197
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
RBX1 CUL1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 12504025 20832730 15448697 10230407 19933270 12840033 12904573 18723677 12504026 12481031 17452440 12609982 26540345 27697867 22474075 11245432 22767593 28152074 22822056 19245792 12706828 11861641 20399188 10748083 11956208 11483504 27910872 16759355 30349055 10713156 11027288 21765416 20638939 22405651 23770852 19942853 10648623 12565873 18826954 18805092 32145688 21169563 27591266 22660580 11961546 32313199 15361859 19250909 29863914 24949976 10230406 32726803 30653357 32015321 33692209 16123592 34237211 29958295 29103612 33961781 33504946 12684064 26725323 26344197
MYCN MAX â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 2006410 23792191 26062444 24859015 10229200 1935896 18003922 18488021 27728805 10597290 29028833 25175806 17289033 20946988
MCM3 MCM2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 15232106 28514442 16189514 26167883 31467278 25963833 12614612 22540012 30108253 14681455 23993743 27621311 33961781 16899510 17296731 26344197
CUL1 FBXW7 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ARID1A SMARCA4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BRCA1 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RBBP4 SUZ12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCC2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
DNMT1 UHRF1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
BTRC CUL1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MCM2 MCM7 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MCM6 MCM7 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCA4 SMARCB1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCB1 SMARCC2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCB1 SMARCC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MCM3 MCM7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM4 MCM7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM2 MCM3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM2 MCM4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM3 MCM4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EED SUZ12 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CDK2 HIST1H1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 MDM4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM4 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MAX MYC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EZH2 SUZ12 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MAPK14 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 17081983 18767875 21098032 20506250 26359454 19690332 11060298 19413330 12788955 10085140 22037767 11566021 17079470 19647037 10581204 10777545 7535770 23331499 7839144 19324872 21071413 21614932 20068231 16393692 15304344 17570479 17380123 18988627 7737130 18669648 15187187 9305639 7737129 15140942 602896 11896587 17548358 12110590 7824938 8663524 33893075 12024021 11078583 11971971 9707433 17258390 10821277 19651622 19436832 11259586 27726305 11781825 9430721 27142525 10909971 12118074 15569672 15212693 9753474 11274345 10903740 26987986
RB1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1641004 11566021
SMAD4 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10085140
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 DDB2 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
E2F6 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17096023 19466541 12909625
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
BRCA1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20160719 18851829 9000507 21407215
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
CDK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8764100 10373534 10550055 19683496 16713569 26719576 15212693
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
E2F6 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18319725 12909625
CDK1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9244350 21706030 10550055 17570479 19683496 16713569 26745677 32193285 26719576
BRCA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11085509 16713569 11016951
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
H4C6 BRD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 27991587 24361270 12840145 18500820 24525235 19766566
CDK1 MCM2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 MCM7 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 MCM4 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 MCM3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 RB1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 MCM6 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
MYC CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18802399 2237430 8065306 11085504
E2F1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15510213 7623816 14618416 12760745 11799067 8137237 12629169 17108174
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
CDK1 MCM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17081983 17303408 19793801 15279786 7575488 11454864 16517729 20068231 17116885 17582221 16519687 18669648 18590585 12714602 17660363 17296725 17924679 17102137 16964243
CDK1 CSNK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16335537 1939094 19007248 17081983 25788269 18691976 20230923 20068231 19387552 17570479 12551973 12396231 19581576 7578274 18669648
CDK1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15735705
CDK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 26573794 12569365 22275373 25704883 17043241 23321516 9725910 24480624 21799006 24424504 28062857 21820033 25950519 28415597 27450452 25691442 21782001
CDK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 17303408 19690332 15084261 19413330 19664995 15279786 7575488 21249227 92097548 20068231 18669648 18590585 1756735 17660363 19651622 20058876 18220336 10542199 19664994
CDK1 FOXM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23240008 19737929 28387346 19160488 15024056
CDK1 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 7575488 18590585 17296725 17303408 18524952 17242355 17102137 17116885 19793801 17582221 17660363 15279786 21658608
CDK1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19107194 17570479 24011073 28756945
CDK1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 21902831 10942602 17014844 10082583 10764802 9710583 14749395
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 HMGA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 17081983 20068230 17924679 17960875 20068231 2168176 17570479 1939057 19413330 20123066 19664995 18669648 15302935
CDK1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7575488 18590585 17303408 8087847 27175585 17570479 17660363 15279786
CDK1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 25841987 34381492 25691891 27941792 27653691 23549878 25800736 22187039 23241245 25038756 25334066 22964433 27716745 20935635 21131960 29576612 33593912 21123648 23438432 21659531 26552009
CDK1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21565170 27220480
MYC CDK2 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
MYC CDK2 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
RB1 CDK2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 MCM4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 MCM6 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10197981 11283614 12193595 14536078 15147722 15241418 15279786 16156666 17055429 17303408 17660363 18590585 18636226 20027199 20713526 2191300 28536364 7575488
CDK2 RB1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
CDK2 MCM2 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 E2F1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
CDK2 MCM7 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 MCM3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
CDK2 BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
CDK2 ZBTB16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18246121
CDK2 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21565170
CDK2 MCM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 17081983 17303408 19793801 15279786 7575488 11454864 16517729 20068231 17116885 17582221 16519687 10748114 18669648 18590585 12714602 17660363 19651622 17296725 17924679 17102137 16964243
CDK2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 8386367 27653698 17081983 19966300 18669648 29896817 17570479 20713526 17558397 15103331 22348395 20445224
CDK2 HMGA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17960875 17570479 21319273
CDK2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 10197981 15241418 19218245 25241761 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 15212693 19114991
CDK2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20935635 25800736 29576612 23241245 32368395 29556394 17570479 27863310 26279746
CDK2 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7575488 18590585 17296725 17303408 21965652 30062004 17102137 17116885 19793801 17582221 15232106 16189514 17660363 15279786
CDK2 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20857408 17570479 11042701 9188854 11157749 12006580 15212693 10825149
CDK2 FOXM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28387346 15024056 19737929
CDK2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 7575488 18590585 9315635 17303408 17570479 25101673 16213134 17660363 12006580 11420722 15279786
CDK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 26581405 9315635 17303408 18692063 23437375 19413330 20871633 26148348 28806746 15279786 16326706 8626527 21902831 14627988 7575488 9190208 21697511 9139732 20068231 17570479 16189514 12006580 11420722 18669648 15811853 18590585 27507850 17380128 23160093 19638577 1756735 20418918 19262748 17660363 11777937 10499802 19651622 20058876 15173007 22263797 10207050 8756624 10542199 19664994 24466208
CDK2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 21902831 10942602 25751651 25552934 22179841 17570479 10082583 26825227 10764802 9710583
CDK2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10428798 22431515 23390529 17570479 23770852
CDK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 24173284 9315650 19413330 19664995 16083285 1088347 16552184 10884347 17570479 10747897 25241761 7624134 11687964 17287340 92065884 12064478 19556892 14640983 10348343 14702041
CDK2 MCM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7575488 18590585 17296725 17303408 16899510 17102137 17116885 19793801 17582221 16446360 17570479 26549452 17660363 15279786
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
RBX1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
E2F1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9418871 19376752 17173070
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
E2F1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   PROTEIN_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 MCM7 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15279786 17218262 17303408 17660363 18328430 18590585 7575488
E2F1 RB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
E2F1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15711575 12110166 20971808
E2F1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21966451 17178887 22508987 21099110 21099103
E2F1 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12438307 16931907 14645238
E2F1 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24453336 12838312 15361834 23023523
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11533237 16081466 16738312 16188218 15618023 14681231 16230367 15985428 8264596 18583990 16601104 14627987 15016799 11268000 10490838 11818069
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
E2F6 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18562691 18319725 9689056 12004135 12909625
RB1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 17145710 23472054 12502741 22078878 8896460 12397079 9315635 20839231 16249186 11839806 8255752 11713253 20871633 15837424 8346196 19249677 16360038 8626527 12096339 15485814 16374512 18391203 9125176 16766265 9468140 8816798 12598654 10393912 9400991 9632788 12947005 19477924 15485920 17380128 10523633 10869426 7828850 18216119 8657117 12963846 25257171 17488475 28074012 15670817 11583618 7739537 10499802 8413249 11090181 8230483 22768064 29521627 10207050 9553123 7958924 11420730 23001041 16496386 9501179 19058874 1388726 9422723
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
E2F1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20211142 15133492 22327218 7892279 16360038 9199321 8405995 9704927 8816798 9780002 8657117 9464260 22629304 7739537 27705803 25368385 9501179 8816502 8832394
E2F1 EED â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
E2F1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
E2F1 KAT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 36292703 20972224
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
SIRT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15632193 19047049
EP300 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10944526 9001254
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19423655 11689053 16332960
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21875947 19270680 19158375 20587414
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11486036 7758944 18542060 9199306 17510411
RBX1 FBXW7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15546612 18094723 11585921 11461910 11565034
FBXW7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15498494 17145710 32047362 28007894 31569395 33821962 20399964 20970423 17157259 16023596 20852628 15103331 15150404
MYC FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20658516 18798339 12695333 17341548
FOXM1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17141659 10567581 17655499 16965535 11391529
TP53 HIC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19649206 19491197 16301995 17079468
HIC1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19649206 16269335 19525223 21277938 20693263 17638871 22064865 23704280
HIC1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283066 16269335
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
RELA IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27371733 21131967 23195252 17612514 27076634 21106671
KAT2A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19407812 34811519 20224553
KAT2A SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11058129 15009097
KAT2A SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11058129 15009097
KAT2A MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11804596 19407812 15522869 12660246
AR KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18945670 20610535 11328859 23095762
TP53 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9266967 20094059 15153330 17611664 18945670 14614455 17293853
KAT2B MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 9659901 10944526 10619020
KAT2B SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 34576109 17074756 11058129
KAT2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19680552 11804596 12068014 16537920 9891054 10490106 14614455 20589832 19788416 12660246 12501250 16959611 19407812 9744860 15965232 16678111 17977830 17189186
KAT2B CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9687573 8684459 9687513 9445475 11864601 9267036 17496784
KAT2B AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504
KAT2B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11058129 15994459
KDM1A H3-3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H3C2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H4C6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A H3C14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A ESR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17805299 26334721 19381457
KDM1A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16223729 20210320 18343668 20228790 15620353
KDM1A AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17277772 16079795
TRAF6 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
MAPK14 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 21675959 26247731 20213747 17535811 20506250 15657900 9315650 15642743 19413330 11283254 22975381 10581258 16083285 1088347 21614932 16393692 10884347 21050851 16552184 10747897 15187187 17906639 25789565 15140942 11258706 24818748 19436832 10781582 10212189 17172861 10348343 11078726 11274345
MAPK14 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 10201984 18691976 17502367 17570479
MAPK14 CSNK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15649893 16648474 15371334 17570479 17072322 10747897 17255949 11274345 12697810
MAPK14 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11439341 17599043 9190208 15355984 17380128 22279936 27642049 33419772 1756735 17996702 17570479 22895174 20871633 20223825 33219128
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21902831 30022044 17570479 27494834 28067271
MAPK14 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20626350 11278789
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
MAPK14 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 10197981 15241418 14512875 16156666 15520018
MAPK14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12842894 15128824 15485852 10521409 15489227 15849198 15212693 12767944
MAPK14 MAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15187187 19651622 23331499 11535131 18039929 7479834 18452278 12738796 11274345
MCM7 MCM3 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM4 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM6 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM3 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM6 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM7 MCM4 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MYCN MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17826980 15668898
HDAC3 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
AKT1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
HDAC3 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
MYC MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15655352 12695333 19649205 10348347
MYCN MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15917661 15644444 15927364 19649205
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
USP7 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 17936559 26460617 15916963 24462112 22056774 18566590 20816748 16402859 20713061 16943424 17380154 29236775 16082221 26238070 34799561 16845383 16474402 28406480 27452404 28196907
AKT1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 11756412 11923280 20856200 20452955 20398329 18332867 19664995 10217147 11154281 19216069 20214616 11463845 19166854 15527798 9829964 17570479 16680151 17646672 12145204 15169778 15140942 25241761 11715018 25209720 17680028 21930127 11504915 29311840 15574337 23397142
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 17145710 10218570 17616658 16511560 22266850 12874296 21925390 25825738 21988832 25512388 16227609 22493164 22902369 25659040 18219319 12963717 15604276 18566590 12370303 19838211 26359458 27617579 25809483 34551723 10608892 23028042 22120712 25703327 12860999 32300648 16055726 24813712 17301054 12483531 23671280 17159902 27621617 25105592 20484049 20724842 27215386 10827196 26001071 11606419 23946421 19683495 20705607 24755078 25384516 20473904 12393902
MDM2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16374512 21990374 7791904 28615518 33185004 20871633 10078201
MDM2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17974989 26411689 27835608 26973243 15640443 12145204
MDM2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15195100 12759344 14507915 16713569 12915590
TP53 MDM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16492744 18172009 21750655 20036872 21422812 17510313 9926934 18336191 19521340 20372076 10469568 20080970 22290440 21394211 23474762
USP7 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20713061 35044719 18566590 15916963 16082221
AKT1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16163388 18356162 16511560
MDM4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 25609649 18677113 28487147 24445145 30045945 20515689 26148237 22266850 11528400 19521340 21088494 16713569 15916963 9226370 12874296 21925390 16024788 25825738 24667498 16227609 24127580 8895579 20174603 18485870 12963717 15604276 25464845 12370303 10608892 23028042 25961923 26186194 17110929 22374672 26876197 17301054 23671280 21965653 17875722 22807444 10075736 19305137 17080083 29023092 27114532 20724842 10827196 19255450 24659749 28035068 23946421 20705607 19075013 21075307 12393902 11223036
STAT3 MUC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17151127 11084045 19578748 21325207 24491543
MYC MAX â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC MAX â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16596619 21988832 10229200 17471507 26267534 15572685 18003922 20382893 35140242 17418410 25609649 16352593 31767764 17072308 17289033 10918583 9528857 14749374 21807113 19623651 18620061 25522242 32296183 16140957 16705173 19578763 26496610 12584560 17157259 17643117 24951594 20946988 10465786 12706874 12821782 9184233 17353931 10611234 32140074 8266081 20691906 16410719 21150319 10593926 12660246 27859590 12553908 8224841 10319872 2006410 16287840 16606833 23816886 9708738 17314511 9886493 27705803 33298911 33961781 20936779 12824180 9680483 17700062 29467282 30415952 12391307
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC MAX â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC PPARG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
CTCF MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10625678 8649389 2284094 12032779 19568426 24725430 12524457 8246978 12897849 9591631 1795697
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
PPARG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11973610 17462534 16405739 19075513
SMAD3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15930298 20516082 14993291 17132729 16205635 25238097 11689553 17114344
YY1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9797456 16314465 10528225 8266081 19279113 17287852 10713181 18490439 17434929 16878156 18542060
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
MYC H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12747840 12695333
MYC MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 1850105 7970710 19723804 12101422
MYC MAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508165 15665468 8385351 8649388 8521822 22384171 1406956 17341548
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
YY1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8266081 15805285 18490439 19219071 2191300
MAX MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 17145710 16287840 25609649 12821782 16606833 16596619 21807113 25522242 20691906 19578763 24951594 8224841 17643117 9528857 12391307 16705173 21150319 10229200 21988832 15572685 9680483 2006410 17314511 14749374 12553908 17289033 17418410 19623651 12824180 17157259 12584560 26496610 20946988 20936779 8425218 23816886 17353931 10319872 17471507 18003922 16140957 20382893 12660246 8266081 7565735 32296183 10465786 26267534 17072308 27705803 9184233 18620061 10918583 17700062 10593926 10611234 16352593 9708738
SMARCB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10319872 14559996 14964309 19234532
ZBTB16 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14645547 19723763 19444914 18246121
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
PML SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 15356634 16189514 18988627
CTCF RBBP7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17851529 17761849 25135475 17185360
RBBP7 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
RBBP7 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
CUL1 RBX1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RBX1 RELA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RBX1 CUL1 â—¼   PHYSICAL_INTERACTION 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 CUL1 â—¼   SHARES_COMPLEX 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
AKT1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RBX1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
AKT1 RBX1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RBX1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11359933
RBX1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 154.0 1.0 Omnipath 17053147 12684064 20638939 11967263 19797085 19258535 26540345 18826954 15071497 15448697 21765416 25730849 10230406 23343194 21169563 22270359 19250909 23732914 11359933 12051714 20006983 15361859 10748083 19352404 22682247 18787170 12504025 18636226 16469695 15459660 20211143 10535940 15001769 26725323 19411070 11861641 26159692 16697054 1570337 19751508 22822056 11348595 7542250 7641885 19849719 16759355 12820959 17452440 19622404 15703371 10648623 19245792 23331499 9694792 19150432 23180781 19597341 16189514 22474075 18988627 22767593 17143292 24949976 10713156 23770852 22405651 19942853 18196958 20399188 16713974 26192618 11027288 17884153 19933270 22730322 21411632 11961546 17936032 19809470 15147722 19270156 19576224 11483504 20976471 12504026 24023259 12840033 15340381 12904573 20558317 11900249 14536078 19686080 12565873 18805092 15489953 19557001 26885856 17652783 12481031 20843316 11955436 21071413 16039586 11956208 20705860 8666229 17928543 10023660 19836308 16940750 12706828 19143635 15688063 10671552 16123592 19366350 19847258 12417738 11245432 20832730 12648680 12609982 19619488 10230407 18931676
RELA SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20617556 15152190 24064732
SIRT1 RELB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19408108 15152190 21245135 18193389
SIRT1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19408108 25217963 15152190 21081649
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
AR SMARCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535 17721441
SMARCB1 SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 18414052 23540691 20506188 8895581 31759698
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
SMARCA4 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 12917342 23540691 9891079 28420882
AKT1 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17570479 16568092
SMAD3 SNAI1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SNAI1 SIN3A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
SMAD3 SNAI1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SNAI1 SIN3A â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
SMAD4 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD3 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20731704 9389648 18832382 16831886 17563753 22406545 11074002 21317430 16617148 17671186
LATS2 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 34335956 27840647 26831822 21952048 24168186
STAT3 POU5F1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 19151334 20505821 15277698 18212089 17068183
JAK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
STAT3 IL1B â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
TRIM28 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18381204 18037959
NCOA1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11773079 16713569 15313931
JAK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 167.0 1.0 Omnipath 10918587 8272872 16319070 18718905 15592455 34066153 23166634 33986510 17389395 29162862 29449694 33512408 21098725 9083098 17565041 27748760 27344175 34031055 29290793 21285325 33846242 33774038 9566874 25962054 20826784 14551213 26188635 26008966 15284024 26175413 21481791 33774344 26307676 9305919 10925297 15615703 12626508 16497976 32087696 16469875 31914141 23331499 11350938 28978186 16306356 33824475 18988627 17401459 19147545 15151905 12637586 34433042 8626374 15950906 27181202 24793791 20455003 21575192 32094172 15322111 17016520 34247191 19901323 12626585 27086926 21166956 23906537 31976162 9211920 12576423 22306293 10207096 12075083 11294897 26787900 12244095 14701810 33909625 11803465 17360477 28827891 33820781 19159681 18939995 11445068 27941883 11429593 30054295 26675255 11850821 9582023 34067421 34707127 15786731 25986861 27351213 34118143 15077188 26699492 12595539 21071413 18498667 22153071 15156153 33513694 25915428 11940572 12529382 18525315 24501689 33839684 24316223 19834108 9575217
STAT3 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15870198 16861352 25854163
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
STUB1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14701756 22298955 23344957 21454478 15761153 15708501
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
YY1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10787423 10634504 8816507 10505791 18391986
MYCN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20811720 11107122 10050884 21862876 20145147 19885598
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
TP53 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23677994 19501055 18220474 21382456
TP53 MRPL41 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10321740 11313981 14743206 15077176 11429705 11158615 12374749 12384701 12024039 15192123 16009130 11919562 11313463 10777217 24388982 24006445 12702557
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
TP53 USP7 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 16402859 15053880 16474402 11923872
MED1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15848166 9444950 16713569 11118038
WT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16713569 10744705 8389468
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
USP7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 26460617 21845734 23382381 16713569 25283148 15916963 18375498 19918835 24462112 22056774 17268548 22653443 23388826 21170034 20816748 17525743 16402859 11923872 17380154 16082221 26238070 16845383 16474402 35538032 22084066
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
TP53 BHLHE40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22723347 17347673
TRIM28 SETDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11959841
HDAC3 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11486036 9346952 17925399 16189514 18940814
RB1 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12588874 11118439
UHRF1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19798101 22064703 20210320 17673620 24368767 19800870 27049577 20613874 21268065 24782312 26065575 17934516 21045206 21745816 19308066 27045799
RELA BHLHE40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22967044 20018891
HAT1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 28143904 22615379 22228774 9427644 19862764 11585814
MYOD1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 7970718 10373569 10601020 10801445 16936743 12665587 20053773
CREBBP MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10944526 16713569 11463815 9238849 2176177
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
BTRC SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15855639 15314162 16865698 26022109 25373906 16189514 14988407
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
CREBBP SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16751102 18003620 9679056 15750622 17283070 20403362 17074756 15231748
SMURF2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 35509688 27447855 15221015 11016919 23331499 22045334 18729074 35379779 11389444 19122240 11158580 15231748 14507671 19620243 20937913
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 12457461 12524424
SMAD3 FOXP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26365427 22908322 25065622 18157133 23243069 20937549 19701891
CUL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11359933
BTRC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11359933
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
SMAD3 MAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 25241761 16189514 12551947
SMAD3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11555647 23331499
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
IL1B JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10198225 7528775 9038232 8943050 9454765 7594594
JAK2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19783980 27275536 21156283 27799566 32232334
JAK2 PRMT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25662273 10531356 21316606
JAK2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 27468692 27494834 25038756 24469040 30159126
HDAC3 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 PPARG â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 PPARG â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC3 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11533489 16189514 12419806
HDAC3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17015477 16189514 12479814
HDAC3 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19442252 16865259
RELA CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RELB CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MCM3 MCM2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM2 MCM6 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16902406 12694531 22939629 12614612 25963833 10567526 22540012 8798650 14681455 22863883 33961781 27173435 16899510 17296731 26344197
MCM6 MCM2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16189514 25416956 12694531 20211142 14681455 12207017 12614612 26496610 25963833 30100344 22939629 17296731 26167883 10567526 22540012 22863883 33961781 27173435 16899510 26344197
MCM3 MCM2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM2 MCM6 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM3 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM3 MCM6 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM3 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM3 MCM6 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM6 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM6 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16902406 12694531 12364596 12614612 22939629 26496610 8798650 12207017 22863883 27173435 17296731 26344197
MCM4 MCM6 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
RELA BTRC â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 26596471 27338466 11114294 8413223 20975042 17707233 23383347 11058167 12686724 16433741 23667107 15382119 19122653 24009751 27211851 18566416 15292915 20617571 23056550 12517972 18285351 19843519 22267743 15812237 25161822 22388040 8021507 9878621 14960579 10963848 23195252 11395507 27534992 9058643 15543947 19846753 20696864 8679226 24908318 28389361 27371733 15972680 20336759 10080875 17082635
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
IL1B RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25606026 26999213 22240205 23666959 19197368 25306394 24009751
RELB BTRC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9346238 15340381 16303288 8706131
ESR1 RELB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17369819 20034404 19433448
RELB IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19690169 21078560 19122653 10523657
NCOA1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10777539 15671023 12748280 11463834 14966289 19194461 9792627 18193094 11747826 17400812 17244199 9223281 10594042
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
DNMT1 FOXP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19454658 32905139 23687305 19109157
SMURF2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 14701756 23331499 15221015 11016919 22298955 11158580 32296183 15231748 20937913
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16417524
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26553800 24492612 27521372 26216216 25949795 21151116 21565170
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 H3-3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12588998 12529330
AKT1 POU5F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23041284 24497960
AKT1 PHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24522204 21689744 15173318
BMI1 RNF2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
BMI1 RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16710298 22493164 22902369 20068231 22325352 25355358 17157253 16751658 26496610 16714294 26468281 26151332 12183370 12589020 21772249 25843776 20601937 32296183 21676867 27647897 15563468 27705803 16359901 24457600 19636380
PHB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15140878 17932104 26052702 10938099 12943695
NCOA1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15514032 12163482 23145053 11673464
NCOA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 18451880 9192892 16957778 11014206 16713569 17627277 23975195 15140878 15604093 12738788 17363140 11003650 10454579 16606617 26487511 11165056 10760302 10731636 12630920 14715875 9773983 9427757 9121466 20608937 12714702 9259327 9192902 11358671 10598586 12574227 11113179 12554772 11682626 9774463
DNMT1 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
DNMT1 H3-3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
DNMT1 H3C2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
DNMT1 H3C14 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
EED CTCF â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17851529 17761849 25135475 17185360
EED EZH2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
AR ZBTB16 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15334066 20610535 16637071
AR MED1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17483314 21593191 24778216 23887938
H4C6 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
SUZ12 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
RBBP4 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H3C2 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H3C14 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
EHMT2 DNMT3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19308066
SUZ12 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
RBBP4 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H3-3B DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H4C6 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H3C2 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H3C14 DNMT3B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
EHMT2 DNMT3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19308066
EZH2 RUNX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18430739 22222375 20631058
EZH2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18022353 15196462
PRMT5 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19234465 29227283 15670829 20951943 23071334
PRMT5 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22231400 20084102 15670829
EHMT2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19690169 17194708 22387026
CTCF RBBP4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17851529 17761849 25135475 17185360
WT1 GATA4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9815658 11207191 18445271 11278460
EHMT1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20084102 19010785 20118233
PJA1 SPTBN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16247473
SETDB1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21243721 11791185 11252719 11959841