Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
CHEK2 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
CHEK2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
HMGN1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19079244
HINFP ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17974976
MCPH1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16217032
NBN ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
TP53 ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 9925639 10435622
ATR SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18619531
TP53 CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21859926 16177095
STAT1 CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9374464 11287556
AR CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16007156
CASP2 TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15590671
CASP2 DIABLO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11832478
CASP2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11399776
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
PARP1 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 7596430 376037
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CDK1 MAD2L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11285280 10679238
SMAD7 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15023526 11180003
NCOA3 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22163316 22213475
TFDP1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14618416
MYBL2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15510213
NBN CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25558984 22231403
HINFP CDK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14585971 19590016
SKP2 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16376880 5218183
CDKN1A UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7298683 19536131
CDKN1A DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19541625 0812254106
CDKN1A RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CDKN1A E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
RB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671466 14527674
NCOR2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24821728 24821727
AHR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12203118 24431146
SRF CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20068148 16819512
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
CCNA1 CDKN1A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
STAT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17992189
SMARCA4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414052
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
DDB2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678110
TRIM28 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942393
EGR1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12690110
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
CDKN2A CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CDKN2A CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CDKN2A MTA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1018389108 21555589
AHR CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17070097 15111621
ESR1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 10851069
EZH2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20574448
NBN CHEK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
NBN CHEK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
CHEK2 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
RB1 CHEK2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17380128 5219804
CHEK2 MDM2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15862297 5217705
MEF2C CKM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15040454 8668199
SRF CKM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20404088 8423791
PARP1 DDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
DDB1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
DDB1 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
PARP1 DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
DDX5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18829551
CARM1 E2F1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16938873 0605692103
L3MBTL3 E2F1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0610279104 17517653
E2F1 CARM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16938873 0605692103
E2F1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14706452 18794899
E2F1 MCPH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22136275
E2F1 SP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18342022
E2F1 ATAD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22771493
E2F1 RRP1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20040599
E2F1 MYBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16299810 14618416
E2F1 HIC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19491197 19015639
E2F1 ETV4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18687701
MAPK3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14967450 22802261
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
ATAD2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17998543
PTEN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17218262
ARID3A E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9780002
E2F7 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14633988 18319725
E2F1 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15867357
E2F1 YBX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15313206 18319725
E2F1 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19491197
E2F1 MXD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12444919 18319725
AR ERCC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12593864 12648523
SKP1 FZR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
FZR1 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
TCF7L2 HIC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218688 16724116
CTNNB1 HIC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218688 16724116
HIC1 TCF7L2 â—¼   COLOCALIZATION 2.0 0.8 intact 5218688 16724116
HIC1 CTNNB1 â—¼   COLOCALIZATION 2.0 0.8 intact 5218688 16724116
TP53 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HINFP TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
HINFP TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HINFP RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15541338 14752047
KAT2A SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 12408818
HMGN1 KAT2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16096646
GABPB2 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A MCPH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A EZH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A L3MBTL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A UCHL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
MAPK3 CASP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219611 17290218
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAPK3 PARP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0508606103 16627622
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
RB1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218170 16374512
ELF4 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19380490 23393136
SRSF2 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27524244
CSNK1A1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19759023
TP53 NCOA6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
SMAD3 NCOA6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53BP1 NCOA6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
NCOA6 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
PARP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
PARP1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AR PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 20610535
SP3 PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12657578 15777284
TP53 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10807576
AR PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17721441
TRIM28 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942393
POLA2 KLF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
POLA2 EZH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SIRT1 SETD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1019619108 21245319
SETD7 DNMT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0810362106 19282482
AR SETD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21273441 20610535
SIRT1 SETD7 â—¼   METHYLATION ✅ 2.0 0.8 intact 1019619108 21245319
DNMT1 SETD7 â—¼   METHYLATION ✅ 2.0 0.8 intact 0810362106 19282482
SETD7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18784729
ESR1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21920899 23658738
SMAD3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
SIRT1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22249256 21640770
NR0B2 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375098
SIRT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27776347 28583374
STAT1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16195385
SMARCA4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11950834 33476981
TOPBP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18923429 7296625
TOPBP1 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 8086392 20871591
EGR1 TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16831524
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 TFDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19196987 0812256106
PAX8 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8521821
TP53 E2F7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22802528
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
TP53 EI24 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24014029 20731388
TP53 TRRAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12138177 11779500
TP53 CDC20 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532 17873905
TP53 MTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23552838 22286760
TP53 NDN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10713459 10347180
TP53 TCF7L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14990988
TP53 PRDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20594067 20557878
TP53 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19416861 10082513
TP53 EGR1 â—¼   COLOCALIZATION 2.0 0.8 intact 5216887 14744935
TP53 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16917513
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 RECQL4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15674334
TP53 ABCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10783169
TP53 SERPINB5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HMGN1 TRRAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16096646
TGFB1 UCHL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22344298 16027725
UCHL5 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16027725 27604640
XIAP CASP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547707 9525868
SP1 XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17121920
E2F7 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21248772
E2F7 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14633988 18319725
CDK6 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CDK6 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
SP1 SP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11245974 21958735
SP4 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20435036 15883203
AHR VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17413038 19182260
SMAD7 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15855641 20631490
SP1 VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19147754
SMAD3 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16308570 10828062
EGR1 PDGFB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
STAT1 IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10068671 12244150
STAT1 TLR3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16628196
STAT1 CEBPE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16918696
NRIP1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRAF2 GABPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
CAV1 TRAF2 â—¼   COLOCALIZATION 2.0 0.8 intact 5213300 11112773
SMAD7 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMAD7 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15684397 1568439
SMAD3 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8308197 22045334
SMAD3 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
SMAD3 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259615
SMAD3 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15044954
SMAD3 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14623893
SMAD3 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15292219
SMAD3 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21402155
PTEN CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12176037 6731969
DNMT1 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19339266 21229291
EZH2 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24719098 22956625
CAV1 PTEN â—¼   COLOCALIZATION 2.0 0.8 intact 12176037 6731969
EGR1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
EGR1 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
NR0B2 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17895379 0706736104
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
MTA1 HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23791785 16511565
HDAC1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20037778 19435809
RB1 HDAC1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
RB1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211419 10228159
MYBL2 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219419 17159899
AR SIN3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16254079
SKP1 CDC20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
CDC20 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
ESR1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 19039095
HES6 HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10851137
BTRC SKP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
SKP2 SKP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
DIABLO BIRC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10929712 5212852
SP3 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24219545 10446912
SPI1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14559995 12588990
SPI1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22105598 12032776
SPI1 IGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21812971 8276819
SPI1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22472882 19423615
RB1 SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8434021
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
NCOR2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12589049 10612426
SP3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12200429 20096088
CTNNB1 CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
KLF6 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22277651 16702959
MTA1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24424621 18719363
CDH1 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9734353
AR CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24218937 20610535
TFDP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10684646
ABCB1 CAV1 â—¼   COLOCALIZATION 2.0 0.8 intact 15498565 5217256
TBP EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15169879 9679659
SP1 FHL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16624878 0602109103
SP1 EGR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20121949 7384875
SP1 NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22629304 20200160
SP1 NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8961265
SP1 SRF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10602487 10330138
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
RB1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10850422 7732011
SP1 SLC11A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18786141
NR0B2 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24619556 21725089
EGR1 RBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22431919
EGR1 UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12903198 18174897
EGR1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17011549 12890669
EGR1 IGF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
VHL IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17486080 19509240
ARID4B IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19366832 19906067
FOXJ3 MEF2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19914232
AR MEF2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23598283 20610535
MEF2C NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18079734
MEF2C CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24473123 18758483
CDK4 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CDK4 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CTNNB1 VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16983094 0606850103
AR CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24810056 20610535
PSMB6 EZH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ATAD2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19318566
NCOA3 ATAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0705814104 17998543
RING1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7998286 20601937
NRIP1 CARM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219239 17053781
AR CARM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16492776 16344550
CSNK1A1 CARM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19118383
ZBTB7A CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14701838 18368381
RBL2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8253383 18319725
CTNNB1 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
CTNNB1 NANOG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CTNNB1 BTRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15473860 10882123
RARA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10607566 23331499
DNMT1 NGRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
NANOG DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22795133
ESR1 PKIB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21180879 18414489
ESR1 PRMT2 â—¼   COLOCALIZATION 2.0 0.8 intact 8290857 22093364
E2F5 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12789259 18319725
ESR1 WNT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20126574
MYBL2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 17975021
AR RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12069693 20610535
AR NRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20739403 20610535
AR FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 17975004
AR AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23689136
EZH2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 23239736
AHR AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19815066 17392787
AR PFKFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17721441
RB1 TBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11094070 16713569
CSNK1A1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15747065
UBE3A RARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
RARA CEBPE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14576045 12032776
RARA NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10772826
NCOR2 NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9556573 10612426
ARID4A RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21148318 10496363
RBL2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8253383 18319725
NANOG LEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
ZBTB7A RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18801742 23727861
RB1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15735701 11420704
GABPB1 FHL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16624878 0602109103
SRF IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8455627 7636248
ELF4 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14769796 10625494
MXD3 MAGEA11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
APC BTRC â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
ATM CHEK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 10973490
CDK1 CDK7 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 20360007 11113184 16327805
CDK1 CCNA1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 7799941 1628647 14681455 8565853 16009130
CDKN1A CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16765349 5218735
MDM2 CDKN2A â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 7989562 20713054
DDB1 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 34026424 25189618 24249678 26679995
PARP1 RARA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19377461 25303530 15808511
CCNA1 SKP2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16774918 19270695 17308064 10652300
SP3 SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15247906 11517158 10825178 16734381 9329821 12414801 12200149 23825960
CDK4 RBL1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22094256 12006580
ESR1 UBE3A â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 9891052 16772533 29388081 16314411 31329371 22865929
DNMT1 UBC â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
VHL ATM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 16678111
ATR MTA1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20427275 10545197
XIAP CASP3 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 9525868 6547707
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
DDB1 AHR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19651607 17392787
VHL DDX5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 21942715
KAT2B KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10373431 24981860
ESR1 KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16260778 31527615
SP1 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16050810 15647279
SMAD3 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22995475 15009097 11058129 15994459
KAT2B NCOA3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9445475 9346901 9267036
UBC MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 19166840 6823655
PDGFB MDM2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ESR1 PURA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33731348 31527615
RRP1B PHB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20926688 27025967
SMAD7 LEF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15750622 15684397
SMAD3 NR4A1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33990575 21988832
HDAC1 RING1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26496610
BRMS1 HDAC2 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
MTA1 SIN3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12920132 24981860
SKP1 ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31527615 23770852
SKP2 PHB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30555578 20134482
RBL2 RBL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15467457 17531812
TFDP1 RING1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
CDC20 CDK1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
EGR1 TP53 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
CASP3 MDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 9278461 24842904 9840926 21726810
CASP3 PARP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19549685 32223133 8642305 7596430 19713971 22451931 17167422 9875225 18723680
CCNE1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9053846 9891079 1388288
CCNE1 CDK7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NCOA3 E2F1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16938873 15169882 16648476
ESR1 KDM1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 17289570 31527615
KDM1A EZH2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31130994 23455924
PARP1 PHB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34079125 24140708 27025967
UBC XIAP â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
SMAD3 CDC27 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 11691834
EZH2 SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24981860 27634302 27705803
SKP2 CDC20 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26811472 25306918 20663873 33961781 15014502
SKP1 RING1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 27705803 24981860
CCNA2 CCNA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CCNA2 PHF8 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 33010150
RBBP4 MTA1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
PHF8 RARA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23518351 20548336
RBL2 CCNE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9891079 8253383
CCNE1 RBL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8230483 9891079
FHL2 NRF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 25416956 33961781
CHEK2 TP53BP1 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
ATM NBN â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10802669
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
IGF1R IGF2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CREBBP NCOA6 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
NDN TP53 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
ATR CHEK2 â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10973490
KAT2B MDM2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK1 CDC20 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 10799291 26912231
CDK2 TFDP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 9199321 25852190
CCNA2 CDK7 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 11113184 33961781 26186194 16327805
EZH2 DDB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23238014 27634302
E2F1 NRIP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20410059 22629304
ESR1 RRP1B â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21182205 31527615
UBE3A UCHL5 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 22645313 33961781 26186194 29426014 24743594
CCNE1 CDK6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
HDAC2 SP3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17548428 12151407 12176973
SIN3A BRMS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15451426 21258344 23390556 14581478
EGR1 SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20121949 12569082
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
CCNE1 CDK4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
ESR1 PA2G4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31527615 20348541
ESR1 SRSF2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21182205 31527615
ESR1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31527615 17502350
ARID4A RB1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
RBBP4 SP3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12091390 12943729
HIC1 SIRT1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
SMARCA4 TP53 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DDX5 ESR1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
HDAC1 NR0B2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CCNA1 SKP2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DNMT1 MTA1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
KAT2B SMAD3 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SMARCA4 SP1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
MTA1 TP53 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
DNMT1 HDAC2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
KLF6 SP1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
TP53BP1 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDC27 CDH1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ESR1 ASH2L â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21502505 16603732 31527615
CDK1 SKP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 26496610 33422522 33961781 26186194 32707033
CDK2 RBL2 â—¼   PHOSPHORYLATION 0.85 0.85 Signor 11157749
CDK7 E2F1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10428966 23397142 20106982
DDB1 GSPT1 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
BRD2 E2F1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10965846 17111193
KAT2B NR4A1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12082103 16713569
UBC MDM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17290220 19166840 18566590 19098711
PARP1 HDAC2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 16204234 20596014
SP3 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17548428 11517158 17906119 16734381 12176973 12200149
HDAC1 NR0B2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15835920 17895379 21566081 21262773
MTA1 HDAC2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6613464 18451879
NCOR2 HDAC2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 30737378 16481466 11013263
SPI1 TBP â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11593411 8434021
CDH1 SKP2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
RBBP4 SP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 12091390 12943729
RBL2 CDK4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22094256 33961781
DNMT1 EZH2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
RARA UBE3A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9891052 16713569 33995501
NCOA3 NR4A1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12082103 16713569
PTEN TP53 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
NCOA6 RARA â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
CARM1 CREBBP â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
CCNA1 FZR1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
CDC20 FZR1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
AHR RB1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
CDK2 TP53 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24173284
PURA E2F1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15517862 10597240
RING1 E2F1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11583618 27705803
PARP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 16204234 20596014 19470756
ESR1 STAT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25303530 31527615
SKP1 CCNA2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9858587 33422522 26496610 33961781 16209941
BTRC UBC â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
NCOR2 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9702189 14715875 20392877 12738788 9171229 23403292
ESR1 FHL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15666801 31527615
ESR1 RARA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9717844 25303530 25604459
NCOR2 AHR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12139968 15325265 10395741
RBL2 RBBP4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 33961781 17531812
PSMB6 UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
BAP1 UBC â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CDC34 SKP2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
ATR TP53BP1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CCNA1 CDK1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CDK1 SKP2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
BIRC3 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17069460 9384571
CDK2 CDC20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26811472 33961781 25852190 23455922
KAT2B E2F1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24502362 23001041 35140242 19188449 24112038 15123636
E2F1 KAT2A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11418595 35140242 24502362 20972224
TBP MDM2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9388200 16713569 9271120
HDAC1 VHL â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
HDAC1 UHRF2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27743347 15361834 21952639 27114453
HDAC1 TFDP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 27705803
EZH2 HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10581039 24981860 21685935 26344197
HDAC2 VHL â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
CCNF SKP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21640084 31130363 31577344 28954236 33729478 30254149 28614300 20596027 33961781 22632967 17215248
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
DNMT1 MTA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27728808 26344197 21670149 23708667
UHRF2 CCNE1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21952639 15178429
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
CHEK2 TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FZR1 SKP2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SKP1 UBC â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RB1 SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ATR TP53 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMD14 UBE3A â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ARID4A HDAC1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDC20 SKP2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDK7 E2F1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CTNNB1 SKP1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AHR ESR1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
SP1 SP3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CASP3 MDM2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK2 SKP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
GTF2H1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RB1 SMARCA4 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CSNK1A1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK1 EZH2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
AR MAGEA11 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
E2F1 TOPBP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
E2F1 SKP2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ESR1 NCOA6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMARCA2 SMARCA4 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDC20 UBC â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
NCOA6 ASH2L â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17178841 19433796 17925232 12482968 17500065 23870121 23508102 33961781 24981860 34079125 19047629
CDK2 ORC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31160578 11931757
CDK7 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15461668 10949034 31527615
DDB1 DCAF5 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19966799 16949367 16964240
DDB1 KAT2A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11564863 21987584
TRRAP E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9708738 18542057 11418595
NPDC1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9181131 11042687
CCNA1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16774918 10022926
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
KAT2B RARA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9445475 17475621 14581481
KDM1A MTA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21670149 26028330 19703393
NR0B2 MDM2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33889569 22575647 22197810
IGF1R MDM2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25241761 12821780 20195357 28092675 18632619 19165858
DNMT1 PARP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 27728808 23708667
CDK4 CDK6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23455922 28205554 28628118 33961781
CASP8 TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23142077 22179575 17047155 28972304 12887920 16227629 21282461 11340079 30054040
TRAF2 CAV1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11805080 16189514 16713569 11112773 32041822
SMAD3 LEF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10890911 15750622
SMAD3 RBL1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 12150994
BRMS1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 23752268 17000776 16919237 26496610 21258344 33961781 14581478 15451426
BRMS1 HDAC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23752268 16919237 21258344 14581478 15451426
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
PHB RBL1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10376528 16189514
NR0B2 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9773978 11861507
PRDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15282304 19746436 10706618
AHR TBP â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8794892 15641800 16713569
NRIP1 AHR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11551916 10428779
CASP7 BIRC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16339151 30948266 9384571
HDAC1 SMARCA4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
TBP TP53 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CASP3 PARP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IGF1R MDM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MDM2 RB1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BTRC CDC34 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HDAC1 SP3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CARM1 NCOA3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CREBBP KAT2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ARID4A SIN3A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CCNA2 RB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CCNA2 RBL1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CCNE1 RB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SETD7 TP53 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ANAPC11 CDC20 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HDAC2 SMARCA4 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
BTRC CTNNB1 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 10228155
BIRC3 DIABLO â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 NRIP1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
NRIP1 RARA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ATR NBN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17526493 10608806 15758953 23368512
CDK1 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24302728 21308745 26496610 33422522 14681455 23602568 25852190 33961781 12853968 26186194 17679094 32707033 9053846 8463339 19483727
E2F1 CDK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8458319 7969176 9199321 1530885 11245432
CDK7 CDK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7629134 8647086 11113184 15530371 23064645 25852190 8692842 15282296 16327805 23455922 10393546 16191191
SMAD3 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15464984 18548003 19917253
HDAC1 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20663877 20022962 15298701 19995069 17369852
PARP1 E2F1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20133863 14627987
E2F1 MCPH1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23001041 18660752 23697381
HDAC1 KDM1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16079794 19703393 21258344 34050636 11102443 27183383 16140033 21937684 12032298 26496610 22143567 19497860 11171972 17634443 12493763 20856864 20585571 31130994 21670149 26344197 23752268 32882276 17687328 33961781 24981860 28667074
MDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12897156 11178989 16713569 10766163 17545634 31012223
RARA NCOA6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10823961 16713569 10866662 11158331 10567404
NCOA6 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10866662 16794079 10567404 10681503 11773444 26487511
DNMT1 SETD7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21151116 19282482
TRRAP ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31527615 11931763 16260778 12738788 12837248
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
SP1 SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11432852 10878024 12228247 22227581 16714330 11114293
HDAC1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11739383 16481466 11013263
HDAC1 PHB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 12466959 14637159 16964284 17932104 27025967
HDAC1 SPI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14647463 16331260 11593411
HDAC2 DNMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23708667 17967891 21670149 10888872
NCOR2 SIN3A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10944117 10640275 11013263
CDC20 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 27522463 19826003 23007648 19483727 18471975 26496610 25750436 25669885 19098431 26811472 10679238 25306918 32307883 20733051 31455778 26960431 33961781 32152539 26186194
SKP2 CCNE1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11237742 22959436 10790373
RARA SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18270252 10361124 19401466 16713569
ATAD2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25640309 17998543 31527615
NCOA3 CARM1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16923966 17043108 15383283 26267537 18511550 16938873
RBL2 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 12006580 17531812 33961781 26186194 8253383
ORC1 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 11931757 26496610 31160578 33961781 26186194
CCNA2 RBL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 8798463 1532458 12439743 33961781 26186194 8230483 9724724 8491188
CTNNB1 AR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5216126 12588987
DNMT1 EZH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31130994 16357870 22094255 28068325 21378168
AHR ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15837795 19460354 12612060 27420286 17392787 10620335 9611253
TBP ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9259327 16713569 31527615 11595744
ESR1 SP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10816575 16651265 31527615
NCOA3 RARA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25303530 16713569 17475621 9346901 12665583 19144644 15604093 9192892 20413580 16456540
RARA NR0B2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8650544 16189514 16713569 9773978
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
ATM CHEK2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
CDKN1A SKP2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CCNA2 E2F1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CCNA2 RBL2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
NCOR2 RARA â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
AR NCOR2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
NCOA3 RARA â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CDK1 RB1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
CCNF SKP1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
EZH2 HDAC2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ASH2L NCOA6 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CDK2 RBL1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDK2 RBL2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
UBC UCHL5 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
APC CASP3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 10200466 17297457 9973322
CSNK1A1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17910481 12628243 11487578
ATM NBN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24800743 10783165 25088203 11252893 30952868 10608806 17507690 22464731 25895060 10839545 15758953 10839544
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
ATM TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15838517 15494392 15140942
AR CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16007156
CASP3 DIABLO â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14960576 11257231 9230442
CASP3 XIAP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 25241761 11447297 9525868 11257230 19698783 9384571 22815893 15507451 16869888 17291493 15200957 27927753 19273858 18723680 16543147 23074197 11927604 18521960 30522111 23979166 17069460 12624662 15650747 11257232 11359776 33961781 26186194 22072751 9230442
AR CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22038727 20610535 23554843
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
SKP2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 9858587 9636170 25852190 23455922 10559858 19270695 26496610 23602568 16979657 10386600 19686743 15355997 20160477 18604603 22770219 33422522 33961781 26186194 7553852
UHRF2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21952639 15178429 33876395
RBL2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9891079 17531812 25852190 9472014 33961781 26186194 23602568 10825149 23455922 9188854
CDK2 SKP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7553852 26496610 25852190 33961781 9636170 23602568 16979657 23455922
CDK2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11598016 19450264
CDK2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
CDK7 ERCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 8692841 17643375 15220921 8521393 33453189 33961781 10082552 9130708 23602568 28977422 32707033 29568061 26340423
CDKN1A DDAH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A RBBP4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RBL1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDKN1A TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
NR4A1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19584258
TFDP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10029406 10702805 9191053
SIRT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23474493 15130752 21719763
ZBTB7A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19244234 23658227 19471103
HES1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19541765 19321451 11809764
SKP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16376880 25241761
SP3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10649433 17370299
LEF1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
LHX2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
DDB1 DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22118460 28035050 12050362 24249678 26410533 22822215 28416769 29262658 16473935 18593899 30923324 16678110 16964240 20368362 12812979 19295130 16751180 19109893 17360488 16260596 27203177 17392787 10777491 12151405 32985517 14751237 22039351 17041588 12732143 11564863 9418871 19966799 33961781 26186194 34251884 16949367
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
DDX5 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 25604459 12738788 20308691 11250900 21182205 10409727
SKP2 E2F1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12097298 17471231 23868976 27720894 16170383 10559858
RBL1 E2F1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8458319 16360038 9501179 8657117 12096339 8230483 1530885 12401786 23853093
E2F1 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8458319 7969176 12501191 35140242 9724724
E2F1 PHB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12065415 10523633 15141164 14637159 14500729
NR4A1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12947120 24706823
HES1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15467735 19891787
E2F1 BIN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19629135 18348166
E2F1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10914734 20837136
E2F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24502362 17575144 15867357
E2F1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20639906 16835303
E2F1 NCOA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16916939 23660594
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15240700 12389032 18319725
E2F1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18319725 16275992 12214268
SMARCA4 HIC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19015639
KAT2A KAT2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
KAT2B MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21209460 21060154 32404984 14769800 12068014 28286521
KDM1A HDAC2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23752268 32882276 19703393 9804427 12032298 20164337 28667074 26949739 34031383 21258344 26344197 34050636 21670149 24981860 11102443 12493763 16079794 21937684
AR KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16079795 22052438
MAPK3 SP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17685427
AR MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
HDAC1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15640443 33985974 12426395 30818224
NR4A1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17139261 15385570
TRIM28 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16107876
NCOA6 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14645241
RRP1B PARP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 34079125 20926688 19710015
NR4A1 POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PURA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19790234 18413735
SP1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843607 20160399 23704280
NR0B2 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20185821 20375098 21081708
SIRT1 NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22395773 15175761
SMARCA4 LEF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19571879 11532957 21654818
SMARCA4 TCF7L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19571879 11532957 21654818
AR SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16541421
TCF7L2 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20128911 19443654
LEF1 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20128911 16179074
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
STAT1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24655378 14602726
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
TP53 FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18615633 11062252 22796152
TP53 MGA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18371449 20631301 15619621
TP53 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17530187 15456866
HDAC1 TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18381204 21669397
CASP7 XIAP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14512414 16189514 15200957 23979166 31467278 9525868 11257230 19698783 11257232 11257231 9384571 11359776 27927753 23074197 33961781 15580265 18521960 9230442
E2F7 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21248772
CUL2 VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 22086907 28514442 9751722 10823831 15060148 11865071 21942715 27697924 20049704 26743088 11779168 17439941 12604794 9122164 21145461 15611064 19030229 21685897 12048197 10421634 28775317 15601820 10449727 24469044 11384984 10587522 18173839 22286099 17339318 16261165 16611863 23401859 15966899 22234250 9447969 17353931 26751167 18323857 25661653 33137104 11024059 18187417 18523483 10318914 26735018 24981860 33961781 31444342 26846855 17132228
RBL1 CDK6 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK6 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
AR CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 15790678
SP1 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12840223 11297539
NRP1 VEGFA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10409677 9712843 26804163 9529250 11986311 30236477 22897854 11333271 18325345 20363638 11886873 16423422 10498602 22318724 17222790 21939755 16763549
ETV4 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19129951
CTNNB1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16288908 18952601 12810642
EGF STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28542650 19168569 22162832
SP1 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16714330 10843994
RARA SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21310893
SMAD3 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24424784 19597490 21798735
MECOM SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23858473 9665135
HDAC1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11306568 19049980 10575014
SP3 NOX4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21235713
SP1 NOX4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21235713
SIN3A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15695521 28514442 9520398 10640275 14647463 12398767 9150133 10444591 14593184 21258344 12943729 12374985 17956988 11102443 9885572 17962807 26496610 12453419 11171972 16331260 20585571 10220385 25314079 12091390 11931768 17643391 11602581 17827154 12724404 11784859 23752268 18059533 9790534 9804427 26949739 24981860 33961781 19182791 11118440 15451426 12920132 26344197
ESR1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17312152 31527615 24051437 33731348 14722073 21182205 15557281 18451880 14506733 15140878
MTA1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 27098840 21258344 33264408 9885572 26028330 26496610 14722073 20585571 21670149 22939629 18451879 34026424 23752268 29997244 16511565 26949739 10840944 33961781 11146623 24981860 17922035 12920132 26344197
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
HDAC2 MTA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23752268 12431981 30737378 26028330 26949739 20651739 21258344 26344197 12493763 11146623 21670149 24981860 9885572 12920132 17671180 18451879 20071335
RBBP4 SIN3A â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SIN3A RBBP4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9651585 11118440 9150133 27705803 21258344 33961781 24981860 12943729 12453419 11602581 15451426 9150135
CDC20 CDC27 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 24100295 20081372 24464857 20360068 16479161 24781523 25246557 17443180 18471975 18997788 18059335 23239745 23643811 25161877 20054826 14561775 22193957 25750436 20212161 21926987 22280307 21937719 19098431 25673878 26811472 27114510 29700288 25306918 12956947 9811605 23754430 18794143 9628895 17443186 32076268 21525009 22100920 23160376 24811168 20951947 9637688 23443559 9736712 22014574 9734353 18722180 30341343 25156254 17609108 28404789 29432156 26960431 21335556 12196507 32152539 23979597 21454660 17360335 23007861
HES1 NR4A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CEBPE SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12032776 12202480
RARA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23321499 16417649 21110951
LEF1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22933707 17452626 8892228
AR CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18794357 20610535
ORC1 SKP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31160578 16189514 11931757
SKP2 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9858587 26496610 27720894 33422522 16209941 33961781 24632684 15355997 26186194 7553852 31181401 20160477 10559858 33989513 18604603
CCNA2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9858587 15355997 33989513
SKP2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9858587 15355997 33989513
CAV1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11563984 23634843 22230296 19595769
ETV4 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15138262 19483189 17390339
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
SP1 SERPINB5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17376297 16304843
SP1 SERPINE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8268720 21436258 8764573
SP3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9329821 15247906 10825178
EGR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15517885 12890669
KLF6 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15131018 18174288
CDK4 DDAH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDK4 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK4 RBL1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
SP3 UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19733223
NCOA3 CARM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14966289 22977234 15988012
AR CTNNB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
CTNNB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15592430 10987283 12154096
CTNNB1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 21362399 21986938
CSNK1D LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15327769 15747065
NRIP1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26153859 9115274 16439465 26166704 23403292 33731348 21182203 7641693 9192902 8887632
MTA1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16807247 31527615 12167865 12639951 11146623 18451880
NCOA3 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26153859 20392877 15383283 14766010 25728767 21182203 15145444 18484708 11376110 14966289 9346901 20181721 26166704 16331275 28844863 11389589 11050174 12630920 19491275 17158759 23403292 12714702 17646391 9192892 11353774 16923966 18645020 16713569 30418174 10490106 9765300 12554772 26487511
NCOR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17591692 23015261 15802375
ESR1 TRIM16 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 HMGN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8700510 17938209 18414489
NCOA3 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10965917 17108143 19305643
LEF1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16741972 16474850 19351848
AR TBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 9238003
AR TCF7L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12799378 20610535
MAD2L1 CDC27 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 21772247 8284719
MAD2L1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9736712 20212161 16189514
TBP RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9242374 10197586 9400991
RARA NCOR2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19377461 9415406 25303530 16713569 17475621 9380707 16219912 15604093 9256429 7566127 11929748 10082574 20543827
RARA NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21310893
RARA CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11090075
ETV4 NCOA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22505454 18644862 18593949
NCOR2 NR4A1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11559707 16002533 16713569
SP3 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10196209
CCNE1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
LEF1 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21689639
E2F5 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7760804 27705803 24981860 7892279 9464260
E2F5 RBL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7760804 11756542 16600870 17531812
E2F5 MT1G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15735762
RBL1 MYBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12439743 12947099 16189514
TFDP1 MYBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8806697 14618416
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRMS1 HDAC1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CCNA2 SKP2 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CDK6 RB1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
BIRC3 TRAF2 â—¼   UBIQUITINATION ✅ - 0.9 0.9 Signor 18997794
DNMT1 HDAC1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
NRP1 VEGFA â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ARID4B SIN3A â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
CDK1 CDKN1A â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
CDK8 KAT2A â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 29568061 18418385
MTA1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 6613464 18451879
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
KAT2B TP53 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDK2 SKP2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
XIAP DIABLO â—¼   UBIQUITINATION ✅ - 0.91 0.91 Signor 15749826
CDKN2A MDM2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ATM NBN â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
RB1 RBBP4 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
E2F5 RBL2 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CDC20 CDK2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CDK2 FZR1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ASH2L UBC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TP53 UBE3A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
CCNE1 CDK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CDK2 CDK7 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CCNA2 CDKN1A â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CDK4 CDKN2A â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
E2F1 RBL1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
HDAC1 RB1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
RBL1 TFDP1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CCNA1 CDKN1A â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
KAT2B TRRAP â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CCNA2 CDK1 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CDK8 KAT2B â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 29568061 9710619
CDC20 CCNA1 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 19477924 10679238
CTNNB1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5218183 16376880
ESR1 NCOA3 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CDK2 RB1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
CCNA1 CDK2 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ERCC3 TBP â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
BRMS1 SIN3A â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
DNMT1 UHRF2 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
CDK4 RB1 â—¼   PHOSPHORYLATION ✅ - 0.93 0.93 Signor 9139732
KAT2B TRRAP â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 9885574 11509179 24981860 12660246 10966108
EZH2 HDAC1 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
XIAP CASP3 â—¼   UBIQUITINATION ✅ - 0.94 0.94 Signor 11447297
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
EZH2 RBBP4 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
TFDP1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
SMARCB1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
RB1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6550000 10779361
HDAC1 RBL2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 9858615 9724731 10969803
SKP2 SKP1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6540196 18239684
EZH2 RBBP4 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 21123648 26496610 27705803 20123894 34518534 28068325 33961781 24981860 27634302 24457600
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
HDAC2 MTA1 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
CDK2 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 15964852
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
RBL1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 9891079 33422522 25852190 11884610 9472014 33961781 26186194 23602568 8230483 8491188 23455922
CDK2 CCNE1 â—¼   PHOSPHORYLATION ✅ - 0.96 0.96 Signor 19561641
E2F1 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10850422 10409740 8657141 10547281 8657142
KAT2A TRRAP â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16494529 18418385 11931763 10611234 31753913 16260778 10373431 24981860 20508642 12660246 15115762 20946988
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
EZH2 HDAC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 21685935 15520282 10581039 24771265 31130994 22439931 26344197
HDAC1 RBL1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10490602 9724731 16189514
SKP1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 9660940 6547997
KLF6 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12433697 24130502 22169644 25879517
RARA NRIP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 25416956 17641689 10531331 14581481 16713569 12503607 12549917 8887632 10082574
PSMD14 UCHL5 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
DCAF5 DDB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
HDAC2 KDM1A â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
CCNE1 CDKN1A â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
ATM ATR â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
E2F5 RBL1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CCNE2 CDK2 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CCNE2 CDK2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 9840943 28514442 24358021 9858585 26496610 14681455 25852190 9840927 33961781 26186194 23602568 23455922
RB1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5219804 17380128
E2F1 TFDP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31130363 25368385 20211142 28542143 35140242 9780002 8816798 8657117 9199321 19015639 8816502 16360038 15133492 8405995 30867845 8832394 7892279 7739537 9501179 9704927 27705803 22629304 24981860 9464260
MDM2 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
PSMD14 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
TRAF2 BIRC3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 30948266 10753917 21988832 9384571 20385093 19815541 20562859 8643514 16891304 16282325 24464131 8548810 11907583 21331077 27534557 23524849 15310755 23543740 16713569 23007157 33961781
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
RBBP4 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 9520398 19703393 31435636 9150133 10444591 21258344 12943729 11102443 9885572 27068747 10471499 26496610 34518534 20127688 11171972 10734134 11470869 20585571 10220385 12091390 17643391 21670149 11602581 17827154 22939629 9150135 23752268 16713569 9790534 27705803 19686092 24981860 33961781 11302704 11118440 15451426 12920132 26344197
HDAC1 DNMT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22274925 20613874 26794444 10615135 10888886 17707923 17934516 15870198 21670149 27593931 17967891 12473678 23708667
HDAC2 RBBP4 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
SIN3A HDAC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16254079 12398767 21258344 12943729 9885572 9150134 12453419 12493763 14749338 22493095 12082111 25314079 12091390 17827154 12724404 23752268 18059533 9804427 26949739 24981860 15451426 26344197
SKP2 SKP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 18667692 15456869 30254149 18239684 20041211 16275325 12609982 10559858 23911321 26087183 18818696 23261596 31467278 9827542 10918611 19398581 28614300 22464731 29137415 16376880 15452136 19270694 26474281 12813041 34080260 23770852 24085301 29499133 30728155 17463251 23868976 22310285 11961546 9430629 11099048 22632967 10559916 20160477 15469821 22524983 10531035 34237211 29997244 27705803 33422522 33961781 32350066 16880511 27220724 15070733 15342634
TCF7L2 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 11713475 5214798
MTA1 RBBP4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32296183 16189514 25416956 27144666 27098840 18067919 27705803 33961781 24981860 26186194 21670149 24920672 12920132 33264408 26344197
HDAC1 KDM1A â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
KAT2A TRRAP â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CREBBP STAT1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
RB1 TFDP1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ASH2L SETD1A â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CTNNB1 LEF1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CDK2 CCNA2 â—¼   PHOSPHORYLATION ✅ + 0.97 0.97 Signor 10652300
CREBBP NCOA3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
ATR CHEK2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
AR NCOA3 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDKN1A CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16765349 5218735
MAD2L1 CDC20 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 21772247 8284719
CCNA2 CDC20 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
SMARCA2 SMARCB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CDK6 CDKN2A â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TP53 TP53BP1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDC34 UBC â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDC27 MAD2L1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CASP3 XIAP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
BIRC3 TRAF2 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDK4 CDKN1A â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CASP7 XIAP â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
E2F5 TFDP1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
E2F1 TFDP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CCNA2 CDK2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 8475101 28514442 16431923 33854235 11940657 10559988 15189033 17361108 16290148 14681455 17254966 8662825 25852190 15557281 23455922 19483727 18471975 11141566 10924145 15828833 21241890 19631451 11377199 18177895 8684460 26496610 9716181 12853968 11907280 23602568 9724724 15647383 14656438 19773423 12941338 15239650 24302728 25669885 15890360 7630397 8756328 8397207 21447625 22231403 20733051 9660939 24358021 12044161 33422522 11983168 33961781 26186194 7553852 16209941 12244298 9380407 8463339 15455144 10930425
CDK2 CCNE1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 28137908 16431923 29439025 9891079 18559665 33854235 11940657 15004009 17431037 17361108 33854239 14681455 17254967 8867812 23853094 10827081 10330164 8662825 25852190 15557281 9192873 23455922 21092281 14536078 21372285 21241890 19631451 16223725 26496610 1388288 9716181 9472014 15980415 14701826 23602568 8978686 11433299 11132966 24771265 12839982 20587660 19470470 10359664 15514162 17970072 9840943 25728284 9660939 8647086 24358021 7799941 12529437 8756624 33961781 15670215 26186194 20837141 12800980
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
HDAC2 RBBP4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 31435636 21258344 12943729 9885572 34518534 12493763 12091390 21670149 17827154 22939629 16713569 9804427 20388487 27705803 33961781 24981860 11302704 15451426 26344197
ANAPC11 FZR1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
DIABLO XIAP â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
HDAC1 MTA1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PSMB6 PSMD14 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
HDAC1 RBBP4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDK4 RB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
TOPBP1 TP53BP1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MTA1 RBBP4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCB1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CTNNB1 TCF7L2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CDK2 CDKN1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ERCC3 GTF2H1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BTRC CTNNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC11 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CSNK1D APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17910481 15327769 15747065 11487578
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
CDK2 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9781043 16322221 16123081 11292842 10928988
ATM PARP1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM CHEK2 â—¼   ENZYMATIC_REACTION ✅ 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATR ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15510216 10608806 17478428 17124492
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 12433983 12861053 17485521 23146902 10839545 19413330 15302935 27602502 17429352 19523210 24360018 20068231 17507690 17570479 10608806 12598907 18669648 25088203 18003706 11252893 17431132 23097684 10766245 12814430 10802669 21664921 26512707 10839544 11927276 21130714 17525332 12447395 14707289 15733840 15279770 25119968 18644472 28822740
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11756551 18077418 19279141 17525332 17446169
ATM CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 176.0 1.0 Omnipath 26683224 17303408 28852018 10713094 20080130 27545311 9488723 15342622 23941746 26485758 28937603 15279786 24882580 10744722 15125777 25746763 18583988 28051860 17570479 16531125 21329876 23892398 19607708 16940182 26643553 20396397 28259974 25361978 17660363 15459660 19375317 25247188 16311512 23118481 20498628 22030216 25613496 22420423 9407949 17918214 12493754 20859824 26158765 15700044 27558808 11901158 27602502 20637859 16163361 20599567 23638118 16481012 12242661 23847781 12024051 15140942 11728459 12454775 16936775 25450480 28950914 26295265 20160490 22319212 24349411 18006705 20723763 18678890 12805407 20860841 23386996 24050180 11668173 27271602 29304495 12447382 24798733 9889122 23347679 18794134 21147465 21421565 26516160 17715138 21376743 19440053 12773400 10973490 17174984 26442630 15694385 11877377 29022904 18809224 11850621 18787700 12718885 19481982 22743550 20372057 15212693 16085488 19101576 29555944 25954303 24473398 18087292 16794575 24492479 24244353 19793801 25404613 21102523 29156743 23253087 16997395 7575488 25808488 20647331 18584027 21851590 21315088 23705030 15629715 29741650 21772273 11025670 18590585 26610585 15964794 29434792 20068082 23006513 19881958 19230643 12607003 24769180 25249630 15024084 19772495 25714019 18603484 25173936 23666059 19473886 27568553 22808196
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 25128619 22496453 34194047 30323812 26158765 16862143 28607002 19584288 20858735 28851455 18285803 34419074 17833484 22491012 25404613 21642969 28439615 27364555 27602502 26671524 23096706 23935532 28739276 24754998 25905708 28847822 24461736 23318425 23346550 17178852 27432546 27820601 17942393 21868291 32060145 22205726 25846574 26293668 25533843 23034801 23352131 28249048 23633913 17525332 18657500 24794298 23645696 26212333 23050241 22715096 27376578 23370278 24657165 29540829 25173936 19071136 28847828 20424263 34518220 25956864 23554604
ATR TOPBP1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11877377 12766152 15459660 15485915 15798197 16530042 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17582221 18677104 19282663 19622404 19793801
ATR TOPBP1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11877377 12766152 15459660 15485915 15798197 16530042 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17582221 18677104 19282663 19622404 19793801
ATR MDM2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR CHEK2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR PARP1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
HES1 ATR â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
TOPBP1 ATR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16530042 18769153 16285702 18066086
ATR CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 21722802 20859824 26683224 18677104 19622404 15798197 19793801 27545311 23137030 19836377 20647331 20599567 19282663 19658174 17116885 16481012 17582221 11715017 17384638 29741650 12024051 18802408 10973490 9857181 26442630 15459660 17296725 11877377 17102137 12493754
ATR MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 14654783 17296725 20651945 11877377 19788416 18677104 19282663 15798197 17102137 17116885 17582221 19622404 19793801 17384638 15459660
ATR E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22184068 11459832 15494392 15140942 26843428 27028861 20413589 27025900 24741006 23202967 25101673 27903963 27827925 15838517 22174788
ATR NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17715134 15758953 17526493 18077418
ATR TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17145710 22778941 24395704 28468838 12401524 15159397 24877058 15254178 9733515 11483158 15806145 19056039 11875057 15865930 11551930 11883897 19923893 12548019 18697815 29170437 16293623 19010925 11709713 10446957 9363941 21748595 17272272 22797063 12242661 10196661 22084686 10747897 10608806 10673501 12091386 17118344 23892398 9765199 15489221 24037342 15140942 10435622 17241873 10597277 10801407 11711532 17174997 21593792 25201202 9843217 10606744 15024084 15226429 15922368 21415014 21480565 15585169 24947324 9925639 23380594 9733514 11865061 19625493 16390936 10951572 10570149 23311997 12111733 26144601
CASP3 CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9261102 9922454
CASP2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15262979 16193064
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
BIRC3 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9990849 12042762 9384571 17069460
E2F1 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
XIAP CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 23074197 16543147 22072751 12624662 18521960 22815893 11157976 15650747 15200957 11927604 11230124 9384571 16869888 9545235 23979166 18723680 16189514 11359776 15507451 9230442 19273858 26186194 10508158 25241761 12529384 19559631 11257230 12874265 9525868 17291493 11583623 11257232 17069460 12181739 10548111 11447297 15014070 19698783
CASP3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8626669 9535906 16713569 9208847
CASP3 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25241761 9278461 21726810 24842904 9840926
CASP3 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11907276 8090205 7596430 9875225 32223133 10438458 17167422 7774019
CASP3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25241761 9660939 10022118 9799125
CASP3 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10822366 11420704 9092486
CDK7 CDK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11900249 12648680 15703371 16697054 17386261 17884153 19667075 19809470 19847258 7533895
CDK1 CDC20 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 7575488 9892021
CDK1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 RB1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17243194 17303408 17660363 18414028 18590585 7575488
E2F1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15510213 7623816 14618416 12760745 11799067 8137237 12629169 17108174
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
CCNA2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 1833185 10924145 8423786
CDKN1A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9467962 26186194 21308745 15340381 23602568 23543736 24218572 17679094 15077146 26496610 12973835
EIF2AK2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25149538 20395957
CDK7 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 85.0 1.0 Omnipath 16565220 18767875 11113184 33657372 27303922 19690332 19667075 15703371 10913154 14988404 1532335 29793495 20360007 7799941 19158392 19664995 33574676 19809470 8548828 7533895 17386261 34489572 26881937 17554681 20068231 18452278 21900495 18669648 12814430 16327805 18691976 15868411 8441405 21778139 25849598 27908669 12459251 1833185 19651622 22263797 19847258 19707596 17924679 20347419 29435156 18220336 34370741 19369195 22505032 21468563 17884153 12663041 22425727 7944411 12648680 11900249 8344251 16697054 31429764 24970150
CDK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 7575488 18590585 17243194 17303408 21524151 17570479 25607646 29603287 20126263 17660363 30685087 15279786
CDK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20937773
CDK1 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 26573794 12569365 22275373 25704883 17043241 23321516 9725910 24480624 21799006 24424504 28062857 21820033 25950519 28415597 27450452 25691442 21782001
CDK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 17303408 19690332 15084261 19413330 19664995 15279786 7575488 21249227 92097548 20068231 18669648 18590585 1756735 17660363 19651622 20058876 18220336 10542199 19664994
CDK1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19652693 18590585 7575488 16565220 17303408 29084198 33819340 12124778 17570479 17660363 14657031 15279786 15917306
CDK1 NCOA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22163316 17570479
CDK1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19107194 17570479 24011073 28756945
CDK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25398907 28831131 20150555 22266860
CDK1 ORC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7575488 18590585 17296725 17303408 11931757 17102137 17116885 19793801 17582221 17660363 15279786
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7575488 18590585 17303408 8087847 27175585 17570479 17660363 15279786
CDK1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 25841987 34381492 25691891 27941792 27653691 23549878 25800736 22187039 23241245 25038756 25334066 22964433 27716745 20935635 21131960 29576612 33593912 21123648 23438432 21659531 26552009
CDK1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21565170 27220480
CCNE1 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CCNA2 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CCNA1 CDK2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16189514 15583032 25241761 16777603 10559988 14681455 9636170 16159883 9041194 10652300 8565853 12970441 14701826 8397206 14681231 11264176 8397207 15601848 12191604 12190313 7799941 19423708 12800980 16009130
CDK7 CDK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11900249 12648680 15703371 16697054 17386261 17884153 19667075 19809470 19847258 7533895
RB1 CDK2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 FZR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10197981 11283614 12193595 14536078 15147722 15241418 15279786 16156666 17055429 17303408 17660363 18590585 18636226 20027199 20713526 2191300 28536364 7575488
CDK2 RB1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
CDK2 E2F1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
CDK2 CDKN2A â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
MYBL2 CDK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9840932 20857481 8816442 15922873
CDK7 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 18767875 11113184 25271736 7880532 19690332 19667075 15703371 14597612 20360007 21565702 19809470 15302935 8443411 7533895 10085115 15671017 17095507 10886368 17386261 20068231 18452278 9244189 8069918 11840777 1396589 17570665 16325401 16327805 25788262 11959850 15530371 11532001 19056339 9130709 14551212 17192257 19847258 22505032 17884153 20147522 12648680 11900249 16697054 93010995 8393783
SKP1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7553852 23602568 16979657 9636170 26496610 25852190
CDK2 UHRF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 33876395 21952639 15178429
CDK2 MYBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9840932 17081983 10095772 11264176 20068231 10593981 17570479 32979888 15302935
CDK2 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21565170
CDK2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 10197981 15241418 19218245 25241761 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 15212693 19114991
CDK2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20935635 25800736 29576612 23241245 32368395 29556394 17570479 27863310 26279746
CDK2 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20857408 17570479 11042701 9188854 11157749 12006580 15212693 10825149
CDK2 ARID4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21148318
CDK2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 7553852 20160477 23602568 25271736 18239684 28446188 23226679 10386600 19270695 26496610 16189514 25852190 26186194 25788262 9858587 22770219 15355997 10559858 23807222 22311674 16979657 9636170 19686743 19270694 18604603 23455922
CDK2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 7575488 18590585 9315635 17303408 17570479 25101673 16213134 17660363 12006580 11420722 15279786
CDK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 26581405 9315635 17303408 18692063 23437375 19413330 20871633 26148348 28806746 15279786 16326706 8626527 21902831 14627988 7575488 9190208 21697511 9139732 20068231 17570479 16189514 12006580 11420722 18669648 15811853 18590585 27507850 17380128 23160093 19638577 1756735 20418918 19262748 17660363 11777937 10499802 19651622 20058876 15173007 22263797 10207050 8756624 10542199 19664994 24466208
CDK2 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11598127 15577895 9736735 12560341 15558010 20068231 10548110 16123593 15840442 18669648
CDK2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 94.0 1.0 Omnipath 23443559 23455922 10878006 20100570 23602568 15964852 20839231 25416956 23737759 9840943 18850315 11302688 20519948 24358021 19440234 15557281 9472014 9658399 16962592 9736735 12949733 8641969 10022118 15890360 12839982 16765349 17418410 15647383 10874474 15232106 17570479 17698606 12361598 26496610 9632134 24419005 12417722 16189514 26186194 20587660 25241761 8622677 9660939 25483090 12800980 20102411 10918595 12058028 12144826 8242751 9464540 9858587 29899857 23007395 11477082 9218599 12383116 25463440 12730199 8756624 9284049 9380407 9546435 24218572 16964243 15212693 13678583
CDK2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 81.0 1.0 Omnipath 8756328 7553852 11377199 17145710 23602568 11983168 12044161 19483727 12853968 16209941 8397207 15455144 19631451 8475101 24358021 15557281 8684460 12941338 15647383 15890360 21447625 9380407 26496610 11141566 25852190 15189033 14656438 20733051 21241890 10652300 25669885 12244298 26186194 10930425 9660939 10477583 24302728 15239650 19773423 8463339 16290148 10924145 11907280 17361108 17254966 8662825 15828833 18471975 9724724 7630397 10559988 9716181 11940657 23455922
CDK2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10428798 22431515 23390529 17570479 23770852
CDK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 24173284 9315650 19413330 19664995 16083285 1088347 16552184 10884347 17570479 10747897 25241761 7624134 11687964 17287340 92065884 12064478 19556892 14640983 10348343 14702041
CDK2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 17145710 16223725 21092281 15004009 10962581 9840943 8643455 24358021 8861947 21372285 17570479 11237742 10330164 22558078 10652300 19561641 10477583 18691976 23853094 12144826 10500095 1388288 10827081 17970072 28137908 19470470 8756624 10809788 14536078 15364936
CDK7 ERCC3 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK7 GTF2H1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDKN1A CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK4 CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK7 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 10734072 24424504 25943391 21820033 21157430 28638477
CDK7 CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 7533895 19847258 17386261 17884153 19667075 15703371 11959850 12648680 11900249 16697054 19809470
CDK7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 30257348 10949034 15461668 9528769 22879364 12118371 28423697 27748765 15059947 16076840 7491495 12093745 23850489 15528270 7838153
CDK7 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23397142 10428966 17050006
CDK7 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23637584 15670742 15249124 33902658 22135230 12054865 19917671 30532072 11955452 19078967 16713569 21297158 16769902 9230306
CDK7 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7533895 14597415 19847258 8139570 12814430 17386261 16327805 16782892 28368408 17884153 19667075 15703371 14754892 12648680 11900249 12459251 16697054 19809470
CDK7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17591690 11709713 12064478 1088347 16083285 9372954 11483158 9620776 10348343 10884347 16552184 9315650 11007451 9571186 10747897 17898864 1454855 11585729
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
RB1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
TBP CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15280358 17130157 17996705
SP3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 10649433 12434298 18850004 7499379 10625687 11064455 23401853 16103879 19584258 12151347 20301197 19197985 15790310 12773551 8995437 10485470 23676218 12379120 18628250 16810128 16533812 23066038 9819384 10321829
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
NR0B2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14752053 11502738 17074765 19322021
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
E2F1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9748148 9191053 16923815 17008321 10030670 10702805 15048076 17167174
STAT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20738848 11162600 12239594 16449678 21307941 22591439 10023678 10866323
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
SMAD7 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10878024 15922743 20104486 12185267 15555279 11180003
RARA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10356361 24821728 21383775
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
SMAD3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10878024 9618481 14755691 10601254 16819512 17516505 10506225 14647420 14583455
DNMT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21229291 21572997 19056828 16276353 9588214 21868513 23658227
EGR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18316600 20368687 19508870 24384380 17307334 11502738 12690110 21642427
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
SKP2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 32035614 25241761 23261596 17679094 15998794 17477906 19686743 16376880 15980415 18794347 13678583
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
SMAD3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
CDKN1A CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12383116 25241761 8756624 29997244 16982699 7478582 10022926 32814053 15232106 16009130 16189514
CDKN1A TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
CDKN1A CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23443559 26186194 21308745 9660939 8756624 15890360 9380407 8242751 8662825 12947099 9632134 17679094 26496610
CDKN1A RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 10498883 9315635 17303408 10486249 16236519 11520855 15279786 9190208 7575488 10385618 9736735 7736585 19075565 18590585 20068082 9425340 18786381 17660363 10778858 17556661
CDKN1A E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 23443559 31831640 21988832 9472014 17293600 11438644 9380407 12839982 16765349 9632134 25241761 8891332 9660939 8242751 9218599 11477082 8756624 8662825 8637717 9716181 13678583
CDKN1A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23443559 15169570 18850315 9658399 16962592 15232106 9632134 16189514 8622677 15695403 20102411 8242751 9464540 23007395 7626805 9106657 12383116 30193583 17556661 23543736 8756624
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
SP1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10649433 22025288 15067344 17370299 21830402 17225865 12134028 19115249 16239970
ELF4 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20814243 21447739 18596985 19233846
E2F1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11314038 12766778 20664976 10914734 16211008 10594030 11062467 11705881 11526499 15716352 19641316 21765927 22621932 19115249 11870517 12695664 20580656 15175242 17912037
EZH2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19954516 21572997 23289480 23826727
E2F1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11314038 16135794 11883935 12446760 18319725 15175242 11034215
CDKN2A MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 12167711 18541670 23416275 9529249 17426254 12630860 17116689 12085228 15856024 10822382 19166854 12209154 12740913 17158541 16915296 17909018 25809483 9653180 14612427 22120712 16173922 10871849 18418067 24769896 9724636 21133853 10801444 19049976 9529248 16107876 18813780 20713054 18467333 15355988 18583933 20395212 11223036
CDKN2A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17881001 26186194 23602568 9751050 11739795 11556834 9380698 15232106 16713569 17955473 10491434 16915296 17909018
CDKN2A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 17145710 11900540 23602568 9529249 11556834 16161044 17881001 17517622 15065884 9228064 15232106 26496610 10585280 17909018 26186194 17353931 10580009 17955473 10491434 12529334 10719365 28042499 8259215 24855949 8891723 23455922
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CHEK2 TP53 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10710310 10673501 10570149 10673500
TP53 CHEK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15326376 19435816 10531348 19395378 15044452
NBN CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18087292 17303408 20723763 18678890 19793801 9488723 11438675 24050180 15279786 7575488 16163361 18584027 18583988 22743550 16531125 23847781 18590585 15140942 15964794 21376743 12773400 10973490 12607003 17660363 15459660 15024084 19772495 11877377 18809224 11850621 9407949 18006705
CHEK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 18778462 25545885 16893723 15254178 18833288 23892398 12052256 18319725 25372714 15459660 20514219 25174607 28140789 17339337 22420423 18566216 20950777 20651945 15810020 15700044 22891162 17157788 11551930 18725978 10724175 15467443 23351141 20096447 11063934 11709713 15659650 12242661 10656682 15140942 20041275 11728459 18614044 12781359 22649771 18812180 11173129 10570149 15279785 20081365 20860841 11875057 22778557 19923893 24553354 22797063 26384650 23316480 15489221 19788416 10801407 21187893 9843217 9733514 10710310 24358900 21526939 23843721 29805302 9733515 25404613 12548019 21625617 10673501 11447225 17118344 26610585 19544417 28038466 12810724 25823026 15024084 17464182 15862297 19933256 20526329 12111733 20183804 23144912
CHEK2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22558186 27679857 15140942 12717439 23219173 19473886 20860841 15838517 20603083
CHEK2 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15862297 10710310
CHEK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24466208 17380128
CHEK2 VHL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22071692 23315288
TP53 CKM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8710368 9690516 7488858 12760745 9464547 8247545 8389468 9136900 7969181 9571041 7605578
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
E2F1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9418871 19376752 17173070
DDX5 CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
DDX5 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15298701 17369852 20022962
E2F1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   PROTEIN_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 CDC20 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15279786 17218262 17303408 17660363 18590585 7575488
E2F1 PMAIP1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12676992 14684737 14699081 15279786 16888645 17218262 17303408 17660363 18590585 7575488
E2F1 RB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21966451 17178887 22508987 21099110 21099103
E2F1 MT1G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15731768 15735762
E2F1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7623816 11264255 9178900 20580656 14681231 10594784 24335704
E2F1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21653699 19564413 20220142 23518498 8668155 7623816 1059478 14618416 20410059 12565705 17471231 23543735 10594784 24335704 22185819 21454377 11526499 10504464 8618861 8649818
E2F1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16331253 23352642 22372491 24574749 20424123 17471231 23348237 17483325
E2F1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11533237 16081466 16738312 16188218 15618023 14681231 16230367 15985428 8264596 18583990 16601104 14627987 15016799 11268000 10490838 11818069
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
PARP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14627987 20133863
TOPBP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20413589 18660752 14576433 17006541 12697828 14576432
CDK8 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 20616879 18794899 22945643
RB1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 17145710 23472054 12502741 22078878 8896460 12397079 9315635 20839231 16249186 11839806 8255752 11713253 20871633 15837424 8346196 19249677 16360038 8626527 12096339 15485814 16374512 18391203 9125176 16766265 9468140 8816798 12598654 10393912 9400991 9632788 12947005 19477924 15485920 17380128 10523633 10869426 7828850 18216119 8657117 12963846 25257171 17488475 28074012 15670817 11583618 7739537 10499802 8413249 11090181 8230483 22768064 29521627 10207050 9553123 7958924 11420730 23001041 16496386 9501179 19058874 1388726 9422723
CDK6 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
GTF2H1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15123636 10428966 16213134
CCNA2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15840440 16135794 9736735 15133492 15558010 15123636 9556498 12501191 16213134 11980909 16123593
CDK4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCNE1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 18687693 9315635 17303408 17660363 12006580 11420722 15279786
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
CCNA1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17660363 15840440 16135794 18590585 7575488 17303408 9736735 15133492 15558010 15123636 9556498 10022926 16213134 11980909 16123593 11739724 15279786
MCPH1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23697381 18660752 23001041
NDN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24392139 9422723 14593116
E2F1 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12676992 18319725 14699081 16888645 14684737
E2F1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
E2F1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20211142 15133492 22327218 7892279 16360038 9199321 8405995 9704927 8816798 9780002 8657117 9464260 22629304 7739537 27705803 25368385 9501179 8816502 8832394
E2F1 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12096339 8230483 18319725 8657117 23853093 9501179 10766737 16135806 16360038
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
E2F1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
E2F1 MYBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16299810 8760872 10766737 18319725
E2F1 KAT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 36292703 20972224
TBP ERCC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7521915 11089979 22848139 9400991 8087622
GTF2H1 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10403766 10734072 9173976 8194528 15220921 9118947 9130708 8652557 11259578 26340423 17643375
CDC27 FZR1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC27 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12797865 12956947 23029392 18662541 9637688 15916961 22014574 21241890 10500174 26963853
FZR1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12797865 12956947 23029392 18662541 9637688 15916961 22014574 21241890 10500174 26963853
TP53 HIC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19649206 19491197 16301995 17079468
HIC1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19649206 16269335 19525223 21277938 20693263 17638871 22064865 23704280
HIC1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283066 16269335
KAT2A SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11058129 15009097
SP1 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20130956 20144149 17882273 15647279
AR KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18945670 20610535 11328859 23095762
TP53 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9266967 20094059 15153330 17611664 18945670 14614455 17293853
KAT2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19680552 11804596 12068014 16537920 9891054 10490106 14614455 20589832 19788416 12660246 12501250 16959611 19407812 9744860 15965232 16678111 17977830 17189186
KAT2B CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9687573 8684459 9687513 9445475 11864601 9267036 17496784
KAT2B AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504
KAT2B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11058129 15994459
KDM1A ESR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
KDM1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17805299 26334721 19381457
KDM1A AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17277772 16079795
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938135 17088940 16093479 16613989 11467847 7791761
MAPK3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 32205409 20150555 21983342 11904305 14593115 18199680 8226933 14744793 16079281 19318349 20882567 22266860 28574228 21097497 8388392 32615164 16377629 19245816 18775330 9604935 15212693
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MAPK3 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24342355 17290218 26036637 29233910 24484936 20937773
MAPK3 MAGEA11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19828458 18212060
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
SNAI2 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
SNAI2 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
SNAI2 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
CSNK1D MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 26294215 11850850 12167711 16055726 15610030 15688025 15703839 20708156 28049764 33618712 15024078 19630168 26636645 19008219 27617579
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16374512 21990374 7791904 28615518 33185004 20871633 10078201
MDM2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 25241761 28092675 12821780 18632619 17303558 19165858 36042202 20195357
MDM2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17974989 26411689 27835608 26973243 15640443 12145204
NBN PARP1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
SIRT1 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17612497
SP1 PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9428683 9493965 17003407 17961220 11278663 12657578 15777284
CASP7 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9875225 1558065 16374543 11058599 9463409 11170436
PARP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9312059 17891139 15044383 12898523 14627987 16713569 9565608
ESR1 PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18414489 22216287
AR PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20610535 17721441 16479009
TP53 PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10807576 23959540 15580300 19797274 15856024 20591651 22216287 14695212 14500851 20195489 21969549 18042711 20160496 15598651
SETD7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21988832 17805299 15525938 16415881 17108971 21245319
SIRT1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21071413 23331499 17098745
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
AR SMARCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535 17721441
SMARCB1 SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 18414052 23540691 20506188 8895581 31759698
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
SMARCA4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11532957 14964309
HDAC1 SNAI2 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
SNAI2 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
SNAI2 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 SNAI2 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
SNAI2 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
SNAI2 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 SNAI2 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
SNAI2 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
SNAI2 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
SNAI2 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23031797 23189137 23054398 11912130 21081648 23160379 20455091 19635798 16943193 24424621 15300012 20139075 24703882 12855644 23637992 23518002 19448627 16273209 18385519 20071775 22933707 24297167 20332115 17655524 22899291 22567133 20053763 15311212 21593765 19389926 20182623 21796367
CTNNB1 SNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20731704 19751508 7542250 11967263 22406545 17093497 21317430 11955436 22270359 18832382 12051714 8666229 12490555 16510505 16940750 21199805 17550342 16831886 14623871
LEF1 SNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20731704 19751508 7542250 11967263 22406545 17093497 21317430 11955436 22270359 18832382 12051714 8666229 12490555 16510505 16940750 21199805 17550342 16831886 14623871
SNAI2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 22370643 20519943 12508111 17508028 11309385 19597490 14673164
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
EGR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9242687 17822668 15958557 12755686 16990849
AHR TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17070097 15111621 11191113 20478272
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
TP53 ARID3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12136662 22172947 18431400 12692263
TP53 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 1346476 18234965 8554604 8898977 10745175 19714248 9988237 10029407 11096091 11172607 11920581 17952118 8679460 9112432 11350951 8502478 11483599 7949467
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
TP53 SERPINB5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12011991 15578720 17700520 10692390 17204482
TP53 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 8108142 20639906 9377555 21325822 16684540 9833779 10910082 16835303 23449391 8521408 15860260 11971180 11559575
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
TP53 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22957312 15843377 12917634 21637289 17344317 12839924 11545734 18172008 19173293 20554748 19079342 14984207
EIF2AK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 17451862 16083285 1088347 10082513 10348343 10884347 16552184 9315650 9737981 19413330 16713569 10747897
NDN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24722188 10347180 16713569 23785149
TP53BP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25579814 12110597 25837623 16713569 14978302 22653443 26022179 27546791 8016121 12351827 15611139 15364958 14985081 19433796 17805299 25651062 11877378 17634560 22084066 20307547
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
NR4A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23071566 17139261
EGR1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15225550 14744935 11251186 16713569 12384981
CSNK1D TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10606744 16870621 17101137 9349507 25241761 11709713 10930428 10951572 17570479 19345189 11551930 10747897 10734067 10673501 11883897 16713569 18246126
UBE3A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 23040663 7724550 9450543 16713569 16493710 15001357 17131388 9143503 19364824 31971989 11027293 9688277 9369221 1661671 7708685 12620801 8090726 8380895 26789255
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
CSNK1A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 10606744 9765199 20041275 11709713 18246126 27681874 10951572 29793495 10734067 11875057 10747897 10673501 11883897 11551930
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
TP53 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21336307 18431400 18339852 12620407 17409411 18172008 17823410 16713569 21518799 21483453
TP53 ARID3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12136662 15017387 18431400
TRIM28 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18381204
LEF1 TRRAP â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9843967 14695187 16510874 15829968 11080158
TCF7L2 TRRAP â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9843967 14695187 16510874 15829968 11080158
UCHL5 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 16027725 17052192
XIAP DIABLO â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 10929711 11140637 15078891 17435549 22733138 23070005 26587781
XIAP DIABLO â—¼   PROTEIN_INTERACTION 7.0 1.0 ACSN 10929711 11140637 15078891 17435549 22733138 23070005 26587781
DIABLO XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 82.0 1.0 Omnipath 17686459 15280366 11257231 11157976 11606597 15650747 10929712 11927604 12218061 15200957 15541727 12865429 10929711 11801603 14512414 27476169 15178455 16189514 25246529 15300255 15507451 11140637 11604410 11140638 15078891 14523016 12525502 20957035 12660240 17179183 25801170 11257230 11242052 23251006 23818254 11801595 16282325 19506082 31699976 12511567 17724022 11583623 11602612 22465666 21185211 15749826 15781261 12181739 19667203 32447208 12121969 10972280
XIAP CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 11447297 11257231 18521960 31467278 15200957 9384571 9545235 14512414 23979166 16189514 11359776 9230442 10508158 19559631 11257230 9525868 11583623 15580265 11257232 23074197 19698783
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RB1 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
NANOG CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22378194 17761754 19139263
CDK6 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 10498883 18590585 7575488 17303408 10385618 9736735 16236519 20068082 19075565 18786381 17660363 12006580 15279786
CDK6 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 43.0 1.0 Omnipath 10498883 9315635 17303408 11416152 15081408 16236519 19690332 16936279 11520855 16107892 19413330 15279786 16360038 9190208 14627988 7575488 24417566 8822197 10385618 9736735 9139732 7736585 19075565 29372101 18590585 27507850 22682621 20068082 9425340 25549286 18786381 17660363 15809340 27811360 10778858 9380698
CDK6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17208333
CDK6 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
CDK6 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10498883 10385618 9736735 11157749 12006580
VHL VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12539169 8625303 9572397 9370235 10581162 19801654 12912922 10189987 9689663 7533661 10804089 8855222
RARA VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15613498 17470563 18326047 11804877
EGR1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9049304 19526316 20489156 15517885 15737464
ESR1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16267616 12400015 17272396 18252963 18497067 10866309 19420388 19398483 16249470 14647449 15774498 12208749 10995484
SMAD3 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15188178 18952601 20631490 22740248 21057546 15629128 11486006 15191565
AR VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16007189 23369005 18768969 18612129 15003169
SP1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 19671799 12509426 12560084 16638750 15342781 10910082 19147754 22992725 15217947 15737464 11904305 12429844 15688401 15544046 12615726 11678207 15188178 18021292 15883203 15477724 18454179 23652833 16239639 23369005 8910439 15026340 11007955 12644537 14597566 18575762 11232768 11731421 12482909 12570801 15582599 16540671 16790435 18632621 9264407 10581162 16788159 11040101 21115498 23765166 11060301 22326662 23506169 15613498 15970595 11191053 10816575 12975317 20435036 16949073 11980848 14647449 15302997 9271438 15039660 16982770 11559575
SP3 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12644537 14597566 12509426 9264407 10816575 20435036 14744778 14662796 15477724 14647449
VEGFA NRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 9529250 17222790 17145710 22897854 15637071 18325345 16763549 20363638 21653826 21939755 11333271 16423422 11181169 9712843 11986311 10409677 22318724 10498602
SP1 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22415074 11222751 15175554 11967988 8662647
EGR1 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11222751 8596917 21368226 9488709 16092976
EIF2AK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23597922 9135145 11278865 16516295 10637230
STAT1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15695802 10848577 9773981 8848048 9037008 16481475 15894584 8986769
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
TRAF2 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18997792 8643514 11907583 16713569 18621737 18997794 21988832 18606850 9384571 16891304 10753917 18981220 24464131 20562859 25241761 23543740 20385093 21331077 23007157 16282325 23524849 8548810 19815541
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
SMAD3 SMAD7 â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD3 SMAD7 â—¼   PROTEIN_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD3 SMAD7 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
TGFB1 SMAD7 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SMAD3 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10823886 15183844 12761881 10887185 10973944 10839991 10753944 10843994 15579469 10559222
SMAD7 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10887185 15855807 9886263 20631490 22656308 19214138 23633623 14600158 10753944 11912247 11385614 11180003 17928287 19010789 22496417 22841502 17074765 15496141 11448947
CTNNB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 15684397 21071413 18988627
TGFB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 14718519 16474430 17934056 20519943 9335507 21900405 11133108 14557817 15548370 19920116
SMAD7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 9892009 26555259 9892110
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 NCOR2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
SMAD3 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
CDK4 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 10197981 12193595 15241418 16156666
SMAD3 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
BTRC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11359933
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
CDK4 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 34003249 10197981 15241418 25241761 19920136 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 33051597 19114991
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
CDK8 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
SMAD3 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12150994 16189514
SMAD3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11555647 23331499
SMAD3 E2F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12150994
SMAD3 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
EGR1 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17330857 17479230 20514024 12917634 17516844 15231710 18062928 18324520 11781575 20862322 16138117 21297666 20959484 16424010 15517593
PTEN AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15205473 24480624
PTEN IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
KLF6 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16611854 18615188 9837963 19076057
EGR1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17916653 20417179 8794351 8058069 8051207 26279418 10783396 16138117 8876223 20690147 16702209 11707452
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
HDAC1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 TCF7L2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10485845 11266540 10559189 20405012
HDAC1 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
HDAC1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20580679 19182791 21685935 21184735 24424621 18794357
HDAC1 SERPINB5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18247378 23770133 10709100
MECOM HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11552981 23858473 16713569 11568182
HDAC1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11994312 16713569 15640443 12612053 10428808
HDAC2 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC2 SIN3A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
HDAC2 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC2 SIN3A â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
HDAC2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15169839 17615296 25241761 22796940 20818389 21685935 15388328 20519943 12508111 11309385 17018611 22514743 19597490 14673164
CDC20 CDC27 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC20 MAD2L1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC27 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156254 12956947 9736712 17443186 22014574 9637688 24781523 16189514 14561775 12196507
MAD2L1 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 89.0 1.0 Omnipath 23443559 20212161 20081372 16525508 9637688 25383541 19098431 23239745 18997788 19143472 21335556 25750436 12196507 15182668 19826003 21743465 16647857 23791783 9736712 25482201 21772247 22100920 20512932 11804586 26496610 16189514 14561775 25092294 11702782 25669885 14607335 25306918 26811472 11438673 21525009 25012665 17443186 21041666 11707408 23754430 18794143 21407176 22340593 24464857 9628895 23643811 17360335 11274370 15694304 24581499 20360068 18592005 26986935 21300909 16497171 10700282 18318601 20054826 25673878 18022367 17443180 21926987 24151075
CDC20 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156254 12956947 9736712 17443186 22014574 9637688 24781523 16189514 14561775 12196507
CDC20 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15577895 10679238 18471975 15840442 25669885
CDC20 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25241761 27509861 18997788 26387737 9734353
CCNE1 SKP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
CCNE2 SKP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
BTRC SKP1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SKP1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
SKP1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
SKP1 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
SKP1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
CASP7 DIABLO â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14960576 11257231 18619610 9230442
DIABLO BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 12525502 10929711 18022362 18022363 11606597 14960576 18485876 10929712
TLR3 CASP8 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22421964 21737330 12752666 15814722 16115877 14739303 21737329 12181749
CASP8 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18073771 9545235 10872455 18329793 9727491 9463409
CASP8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17170703 9535906 16713569
SP1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12706891 22734486 10446912 7478579
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
CREBBP TCF7L2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
CREBBP LEF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
NCOA3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10777539 14966289 22977234 15798179 22608253 11747826
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CARM1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15731352 11701890 12374746 17043108
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
CDH1 CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ESR1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12726856 14500345 17893710 19383788 19593637 20101232
EZH2 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18377425 22130667 21685935 21770894
EZH2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 11309385 17018611 22514743 19597490 20574448 14673164
CDH1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 91.0 1.0 Omnipath 17145710 7542250 11348595 9512503 10652321 19016843 16909210 9233779 17220478 16219695 27177845 25344754 11245482 22752307 16983094 16212417 16574648 18593713 9535896 9819408 12830000 10772923 11801604 23180380 8227214 16546130 10085258 22056988 9700170 12640114 24424122 10381631 17087658 24798214 11226248 12875984 9405455 11712088 12061792 17909039 22158051 11960376 14706341 11254878 15023525 12169098 21255999 16125672 22850631 16126725 11113628 25468996 9326449 17524503 17057644 7876318 11401320 22715382 7954478 18593907 21152425 22375065
CCNE2 SKP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
SP1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16969077 16883603 19329185
SKP2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 11237742 12648680 11900249 16697054 18931676 19809470 15459660
SKP2 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
SP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15531587 10684646 23280667 21631282 17108117
EGR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22198386 22593802 19913601 10395376 18844239 22433566 20472833 24470481
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
AR EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18511414 8580999 7522959 15590903 14662770 18692155 17374439 18212060 20610535
SP3 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21554857 12509426 9632663 10362515 19223508 15857802 20096088 16806531 15854045 15118068 9788252 12773549 16617124 11517158 12554796 9666093 15869407 12888570 11287330 15541732 8845379 16574784 8070411
SP1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15922873 10196209
SP1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10720440 21447702 7497000 15345673 17170218 7491107 17049831 17014845 10982795 17486080
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
SP1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740727 7585542 15831516 9626663
SP1 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20427719 18044710 9282327 8349585 10826704 10082539 12637574
SP1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18234965 7565762 10411657 23133566 10860921 9458366 17363581 7621073 8103518 10644769
SP1 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9778040 16410262 21569840 20478378
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
SP1 ZBTB7A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19444642 23027183 19723341 18368381
SP1 IGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8405433 11327698 11165040 9620554 9610618 12804776 11336542 10606246
SP1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18801742 12760745 8007947 1588949 17384411 21465530 15618023 7896792
SP1 CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17965828 9528783 20506344 17471507
SP1 UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19733223 17409431 11872750
SP1 CES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18305377 11337511 18328811 11409902
SRF EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17967787 12760745 18446785 16497989 16456537 11739517 10329706 15449318
EGR1 IGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14517213 9610618 11336542 8634146 10606246 8276819
EGR1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7565762 10392899 10860921 11488907 23478574 11734301
EGR1 WNT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18281035 21436631
IGF2 IGF1R â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 1310594 3019338 2839228 1845984 2969892 3011795 3013881 22140443 19139090 16981855
IGF2 IGF1R â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11237532 15003992 17145802 17600088 24668028
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
AR IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19318566 15033751 17202144 19250214 20610535
IGF2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9972281 23331499 22810696 20980691 14604834 11867533
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
RB1 CDK4 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CDK4 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 107.0 1.0 Omnipath 26203195 10498883 23336272 9315635 17303408 17363486 25803170 10359571 15081408 16236519 28249908 16936279 17478427 19690332 11520855 31615938 15279786 16326706 18981099 9190208 8626527 14627988 7575488 24417566 9003781 16360038 10385618 9736735 9139732 7736585 20068231 34158578 16189514 19075565 18669648 11773438 11641415 21880723 18590585 27708221 10962560 20068082 15489884 9425340 19225156 19551155 17045206 10210318 19262748 18786381 17660363 17621266 19651622 12657252 11746527 11254678 15809340 22263797 10202152 10778858 27811360 23981302 19664994 14676836 9380698 18583321 23429262 27430527
CDK4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 10498883 17303408 16236519 11884610 8643455 19664995 15279786 7575488 10385618 9736735 19075565 12006580 18590585 20068082 17495531 18786381 17660363 19664994 10069453
CDK4 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10498883 10385618 9736735 11157749 12006580
CDK4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
ATAD2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17998543 25640309
AR UBC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17409431 20610535 17721441
PA2G4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 15583694 9565586 12165860
TBP CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
ESR1 CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
RBL1 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12439743 18319725 1532458 8230483
CCNA2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15840440 16135794 9736735 15133492 15558010 15123636 9556498 16213134 11980909 16123593
TCF7L2 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24214913 14706452 19347947 24317174
AR CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18535113 18673534 20610535 11916967
CTNNB1 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17785445 15473860 11326276 17335794 15728254
BTRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 23514615 17053147 22912335 17145710 27001857 20531388 18851830 12820959 24451375 18805092 25900982 11818547 16798748 19061640 19956254 23331499 24912152 19150432 22017875 24501426 28018973 16376880 21466614 27316454 19053519 26506240 14516475 25149538 10023660 22682247 10228155 9461217 24464578 18354482 26091241 10074433 12114015 9990852 14706645 18650423 25873176 19966869 25515538 20851351 22730322 24469040
CSNK1A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 64.0 1.0 Omnipath 9312064 29495399 14966280 23531534 21764279 26227550 29793495 28220106 20561505 26862734 19293931 19623618 27558955 28430641 11818547 25546293 16199882 24648413 28337019 27672271 11955436 9482734 25915038 20419129 23778311 19244247 25500543 27768599 27488834 28183999 17208333 24594309 24038789 23076981 24904820 23690993 23744610 12000790 23687614 12114015 10488109 26604501 19711366 20699366 25517963 26189775 10023673 22025562
AR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 21741601 16713569 12799378 12944908 10809237 23331499 15060161 21071413 21885566 18988627 16428447 11916967 12588987 11792709 10987273 14593076 15256534 22187462
CSNK1D CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10488109 9312064 23331499 11955436 9482734 14966280 10023673 12000790 11818547 12114015
CTNNB1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 16510874 23151663 11751639 15735151 17143293 16204248 23331499 12556497 21071413 14638683 15768032 18296023 12748295 21743491 11835406 16510875 18077326 8757136 9065403 20123964 15728254 17517646 21078818 15684397 8892228 10890911 15525529 12077367 9419974
CTNNB1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17145710 9488439 11713475 12446687 17143293 27902311 16569639 22014570 16724116 11955446 16442529 26350900 19202075 17050667 20126258 22056988 16306047 17914096 19443654 18391971 21670201 22155184 10080941 17283121 16230076 22304967 16630820 15684397 11713476 12861022 19304756 20492721 19816403 18772112
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
CSNK1D NCOA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19339517
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 NRIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20200160 10379892 16391242 22071320 18414489
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
ESR1 NRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18048642 21486948 23892277
NRIP1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9192902 23331499 8887632 9115274 7641693 26166704 12554755 26153859 21182203 16439465
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
NCOR2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12738788 14715875 9171229 9702189 20392877
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
NR0B2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 21071413 9773978 18988627 11861507
AHR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12612060 17392787 10620335
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
NCOR2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19223455 16373395 21720703 22508987
AR SERPINB5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16304843
NCOA3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 14966121 11747336 15563469 16713569 10965917 21047772
NR0B2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 16713569 11735420
FHL2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17192406 10654935 16713569
NRIP1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9368054 16527872
CASP7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9535906 16713569
NCOR2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 11923464 15062576 14593076 17356171 22508987 12441355 12771131 20812024
NRIP1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 12403842 17641689 8887632 25416956 14581481 16713569 12503607 10082574 12549917 10531331
NR0B2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 8650544 9773978 16713569 11368516
RARA NRIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 12403842 17641689 8887632 25416956 14581481 16713569 12503607 10082574 12549917 10531331
ARID4A RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10490602 1857421 8414517
CCNA1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7575488 18590585 17303408 10022926 16189514 17660363 15279786
BIRC3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16339151 9384571
TFDP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18687693 14618416 12029633 10756032 24335704
RBL1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8643455 18319725 8230483
UHRF2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15178429 21952639
CCNE1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 7575488 18590585 9315635 17303408 17660363 12006580 11420722 15279786
CCNE2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 10207050 9315635 17303408 19638577 17660363 12006580 11420722 15279786
TCF7L2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15473860 20802155 17335794 11326276
MYBL2 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11500496 14506250 8112300 8632901
RBL2 E2F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16600870 17531812 11756542 7760804 15838517
TFDP1 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7958925 12150994 7739537
RBL1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7958925 12150994 7739537
TCF7L2 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15592430 20459685 10987283 12154096
SRF FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22456196 15610731 17975004