Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
MAPK3 EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19564905
CALM2 CALM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CALM1 CALM3 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EGFR BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
S100A4 BTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19740107 7256480
CALM1 CALM2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
JUND APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
JUN JUND â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8922393 2504580
JUND EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12193410 1738590
JUND MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20816750 9136992
JUND MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12226747 21734453
EPS15L1 EPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9723620
EPN1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19054389
PIK3R1 GAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 10978177 6731241
PDGFRB GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14973141
SOS1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
GAB1 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638
GAB1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638
GAB1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
TP53 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19416861 22509910
HDAC6 GRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22193721 8383707
ERBB3 GRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRK2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EGFR GRK2 â—¼   COLOCALIZATION 2.0 0.8 intact 5217433 15620700
GRK2 HDAC6 â—¼   COLOCALIZATION 2.0 0.8 intact 22193721 8383707
EGFR ERBIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23220880 22908275
EGF ERBIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23220880 22908275
SRC ABI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
FGR ABI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 RASA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 HCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 YES1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ABI1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
APP ADAM10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ADAM10 APP â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 20676056 10097139
ADAM10 CDH1 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 18434311 15958533
ADAM17 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0509719103 16641105
ADAM17 TGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26284334 11823465
EGFR ANXA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217387 15581623
EGFR ANXA1 â—¼   COLOCALIZATION 2.0 0.8 intact 5217387 15581623
AP2S1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
GRB2 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
AP2A2 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2A1 MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
AP2A2 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
SMAD1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AP2S1 AP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2A2 MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
AP2S1 AP2A2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
MAPK1 AP2S1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
GRB2 AP2S1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
PPP2CA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RHOA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK12 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CAV1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PDGFRB APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TBP APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PIK3CB APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP2R2A APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2D2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12485888 5215996
APP PLAU â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR2 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15040833 16675543
AR APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16987234
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
NCOA2 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12588987 5216126
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
MYB AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12096342 18945670
AR KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8423674 24172884
AR NR0B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12081648 16857744
AR CALM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16619263 20610535
AR CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24810056 20610535
AR MAPKAPK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23365759 20610535
AR PIK3CB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23365759 20610535
AR CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24218937 20610535
AR ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11371645 20610535
AR TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17011549 11250938
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
AR ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21741601 20587519
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
EGR1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17011549 12890669
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
AR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12933816
AR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15542423
UBE2I ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
HRAS CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8621645 5220985
PLCG1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20808760 1000457
RASA1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731661 15504032
ESR2 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12138116 16423895
PTPN1 CAV1 â—¼   COLOCALIZATION 2.0 0.8 intact 12176037 6731969
CAV1 PTPN6 â—¼   COLOCALIZATION 2.0 0.8 intact 12176037 6731969
CAV1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15976327
YES1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
LMNA CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PDGFRB CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731806 17620338
CBL PTK6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23352614 25019382
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL MET â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5215187 11894096
FGR CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12435267 7721825
SPRY1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16893902 19915061
CBL PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL SH3GL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11894095 16713569
CBL ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
SRC CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17094785 7033811
GRB2 CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 CBLB â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CBLB FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8083187 11904433
CBLB ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
NFKB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21790895
ESR1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11060032 21610700
CCND2 PCGF2 â—¼   COLOCALIZATION 2.0 0.8 intact 16182291 5217962
CDC37 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CDH1 TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDH1 MMP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 17332331 17354228
KLF5 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19628677 21383775
NR2E1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22194602 21957244
STAT5A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15003515 21038417
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
EGR1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12690110
STAT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17992189
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
PLCG1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31575057
MYB CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10542314 15195136
CEBPB HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
CEBPB SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22355693
CEBPB HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
JUN CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17965828 20506344
STAT1 CEBPE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16918696
CEBPE MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12947005
GRB2 CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
PPP2CA CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20133759 0914492107
ZBTB33 CTNND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10207085 5211364
CTNND1 ZBTB33 â—¼   DOWN_REGULATES ✅ - 0.8 0.8 Signor 23481205
PAX6 CTNND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16973151 20074565
GRB2 CYTH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
E2F1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18396012
E2F1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
E2F1 ETV4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18687701
E2F1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
E2F1 ERCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22159227
MAPK3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14967450 22802261
EGFR E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16299810
E2F1 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12944911
E2F1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9368006
E2F1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19303924
STAT1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20217138
ESR1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10432218 18414489
NFKB1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21334436
S100A4 EGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19740107 7256480
EREG EGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
EGF PTPN18 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14660651 25081058
HRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
KRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ETS2 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9639404 18059336
TBP EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15169879 9679659
JUNB EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8314805 17430890
SNAI1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17909010 19604315
MYC EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18365874 11509655
EGF PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 19531499
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
EGF MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20178463 17081983
EGF EPS15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24269888 25728925
EGF SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 17673906
EGF SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 17673906
HGS EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20308550 0911188107
STAT3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731598 14966128
EGFR NRG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7565730 8617750
HBEGF EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19631971 20430953
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
TBP EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9699517 8152794
STAT1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10558875 22693070
EGFR PTPN1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 9355745 6671413
TP53 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
EGR1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11830539
SH3KBP1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11894095
UBE2D3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
JUNB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12791272
UBE2D1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
UBE2D2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 1845983
ELK3 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11566878 23063436
ETS2 EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9207063
EGR1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21283769
EGR1 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11502738 15449318
EGR1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22292946 18068676
EGR1 SPRY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21826097
TP53 EGR1 â—¼   COLOCALIZATION 2.0 0.8 intact 5216887 14744935
STAT3 EGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17129668
EGR1 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
GRB2 ELK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ELK3 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
MAPK3 ELK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11042694
SH3GL2 EMD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LMNA EMD â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 30488537
STAT3 EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23991099
YY1 EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19483472
RELA EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20495570
EPGN ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16469638 16829981
GRB2 EPS15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
EPS15 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
STAT3 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
JAK1 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PTK6 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0805009105 18719096
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
HRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ETS2 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16007139 19109434
JUN ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21384344 16786139
ERBB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11173924 16713569
ERBB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 8026468
ERBB2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
GRB2 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
HCK ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
RASA1 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SRC ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB3 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
NRG1 ERBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10768865 23365119
UBE2D1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
ERBB3 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB3 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB3 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
STAT5A ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18653779 15534001
RASA1 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PIK3R2 ERBB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
ERBB4 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB4 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
ERBB4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912174
ERBB4 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16729043 17496910
JUN ERCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
NFATC4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16219765 17194453
POU1F1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18653622 9702189
WT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
ESR1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10935492 12878732
ESR1 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9259323 8625613
ESR1 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14695898 18252963
ESR1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489
ESR1 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11477071
ESR1 MAPK12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16885352 22399296
ESR1 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
ESR1 MAP3K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15556606 5217326
ESR1 PTPN1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673088 7539106
ESR1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673088 7539106
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10037443
TGFBR2 ETS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ETS2 MMP9 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19847259 23977064
JUN ETS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22354960
ETS2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8649821 10510472
ETV4 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14976186
FGFR1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17496910 25467007
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
PLCG1 FGFR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
FGFR2 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15863030 11353842
FGR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10329689 23109003
HIF1A FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16601206 15192019
HRAS FOSL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SHC1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
HDAC6 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
KDR FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
FYN PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
PTPN2 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22080863
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
TP53 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23940366 9360971
SPRY1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6169676 16893902
PPP2R1A GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
PIK3CA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LCK GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
KDR GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
PTPN6 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10660620 6671678
GRB2 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
GRB2 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7518560 7527043
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
SOS1 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7518560 7527043
SNAI1 HBEGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22641673
HCK PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
HCK PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
HCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10329689 23109003
HGS UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
MET HGS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 8380735
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HIF1A NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14729605
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
HIF1A SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23979441 23496980
STAT1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19646959
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
HRAS PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069260 21779497
HRAS SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
HSP90AA1 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18591668 21465483
HTATIP2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18519672
PIK3R1 IGF1R â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 6730400 7589433
PIK3R3 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611271104 17360667
IGF1R INSRR â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
IGF1R PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 7541045
ITGA6 ITGB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19161977 22118458
LAMB3 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8143784 32196115
LAMA2 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721947 32196115
LAMB2 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721947 10671376
LAMA2 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721947 32196115
ITGB4 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9428518 11733063
JAK1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 8943354 18508557
JAK1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9670964
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
TBP JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17074809 21106530
NFKB1 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17018379
JUNB MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18976709 20816750
STAT3 JUNB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11533249
VTN KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 31677479 32196115
POU1F1 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8910541 12668863
TP53 LAMA4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PIK3R1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220762 8246987
PIK3R2 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
MYB LCK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7970721
LCK PTPN6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 8114715 7028063
LMNB1 LMNA â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
SRC MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK1 SH3GL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 SOS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
PTPN1 MET â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18579758 6731904
MET PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10871282 10648629
PAX6 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19651775
PTPN1 MET â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6764906 16537444
TP53 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
MET PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8662733 7513258
PAX6 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10885745 14673159
MYB PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9371644 7838532
MYB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082531
MYC SH3GLB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15226411 18697203
MYC PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19602047 11509615
STAT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10637230
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
MYC TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9988278
NCOA2 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19305643 10454563
TP53 NFATC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14990988
NFKB1 PTPN6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18948549
WT1 NR0B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12151099 10022915
NR0B1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15155786 23331499
PIK3CA NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17652160 19411071
YES1 PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7685273 6730440
PDGFRB PIK3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730293 1330535
PDGFRB STAT3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17145802 17496910
PDGFRB PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 11172806
PDGFRB PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 8702949
PDGFRB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 9484840
YY1 PICALM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
PIK3CD PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
SHC1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7537361
PIK3CD PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
SH3KBP1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25814554 15021914
PIK3R2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 9651378
SREBF1 PIK3R3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17452746
PIK3R3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32606738
RHOA PIP5K1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 14681219
PLAU VTN â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
RASA1 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
RASA1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9020117 9743338
PPP2R2A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1328247 19114990
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PPP2R2A TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
STAT5A PTPN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12237455 6671710
PTPN1 SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6732073 9600099
STAT3 PTPN1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 15821101 6673264
PTPN1 STAT5A â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 12237455 6671710
RHOA PTPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16644720
PTPN2 STAT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 11909529 12138178
PTPN6 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12220225
PTPN6 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8541543
RASA1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8155326
UBE2I RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25218447 22649547
RPS6KA5 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216210 12628924
RELA STAT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
TGFBR1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19726546 15761153
SRC RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10592173 23027962
SOS1 SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9544989 6547749
SHC1 TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731794 17440088
SOS1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC YES1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TBP TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7666533 17967894
TP53 TGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7651386 11668476
TP53 TGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TGFB1 VTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11796824 16189514
TGFBR2 YY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WT1 UBE2I â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8798754
CBLB PIK3R1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CALM2 SLC9A1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ERBB2 PIK3R2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
IGF1R PIK3R1 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
CBL HCK â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
FGFR1 PIK3R1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
GRB2 MET â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CAV1 RHOA â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 31871319 9647788 20460433
PIK3R1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16273093 5218056
PTPN12 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 28065597
SHC1 FGFR1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 7559490 7514169 16713569 18022941 16189514
PTPN12 SHC1 â—¼   PROXIMITY ✅ 0.81 0.81 mint 27880917
CDH1 SRC â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
PDGFRA PIK3R1 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
ERBB4 STAT5A â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
PIK3R1 SH3KBP1 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
AP2A1 AP2S1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
CBL EPS8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27629044 25814554
MYC AP2A1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC ARF4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
FGFR1 CDC37 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18022941 31980649
CDC37 ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
EGFR LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24780295 26320552
IGF1R ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30898150 17307140
ERBB2 INSRR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 30898150
MET ERBB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21918175 25326665
FGFR2 FGFR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MYC JUN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
TGFB1 LAMB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20936779 27684187
SHC1 PIK3R1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16219545 5217992
FLT1 PIK3R1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
JAK1 STAT5A â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
GRB2 PDGFRB â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
PPP2CA PPP2R1A â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EGR1 TP53 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
FLT1 FLT4 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
SOS1 KRAS â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 25624485
JUN JUND â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25609649
EGFR AP2S1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24189400 25754235 24797263
CBL FGR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 7721825 12435267
NRG1 EGF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 7730382 28988771
ESR1 JUNB â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31527615 11477071
TGFB1 LAMC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
MYC LMNA â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
SNAI1 LMNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24157836 30021884
ERBB4 NRG1 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
EGFR HCK â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
EGFR EPS8 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CALM3 EGFR â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 NCOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 0.83 0.83 Signor 11477071
MTOR STAT3 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CALM3 ESR1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CALM2 ESR1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CBL UBE2D1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
LCK PTPN6 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
AR SRC â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
BLK CDC37 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
BLK CBL â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 8083187 8621719
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
CBLB SHC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9614102 16189514
FGR CDC37 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
EDN1 EDNRA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 7509919 10770212 16713569 23597562 16189514
EGFR EMD â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24797263 28065597 20937808
RASA1 GRB2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12441060 16189514 16713569
MYC HIF1A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15071503 28205554 28628118
HIF1A STAT3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
STAT1 MTOR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19553685 25241761 12807916
MYC TERT â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28205554 28628118 32140074
STAT1 SRC â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 14978237 10358079 9344858 16189514
EGFR PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 1689310
INSRR PTPN1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
KDR PTPN6 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
FOSL1 JUNB â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
ERBB2 LRIG1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ESR2 NCOA2 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
CALM3 SLC9A1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
EGFR AP2A2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 31959764 24797263 23956138 8548289 24189400
CALM1 ESR1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CDC37 HCK â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 11413142 32707033 31980649
PLCG1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 9020117 6805619
RASA1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24412244 16273093 22973453
ERBB4 ERBB3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 7689552 10572067 25315821 20227043
SRC GRB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12624098 9016807 16713569 16189514 11964172
SOS1 HCK â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12029088 23397142 17141806
STAT3 HIF1A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18985005 23604114 15735682 23991099
HIF1A JUN â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
KLF5 NFKB1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 14573617 16713569 16102021
PLCG1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730306 1396585
SRC PLCG1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8657103 7510703 7682059 1689310 16713569 8885868
PLCG1 RASA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9743338 9020117 8977179
PLCG1 SHC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8662733 10652211 8155326
TP53 S100A4 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 19740107 7256480
STAT3 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730629 8662591
TP53 UBE2D1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
EPS8 SOS1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
HCK SOS1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
AP2A2 EPN1 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
GAB1 CAV1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 34079125
MET CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6538879 18273061
MET CBL â—¼   UBIQUITINATION ✅ 0.86 0.86 mint 11894096 5215187
LCK CDC37 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 34079125
HDAC6 ERBB2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
ERBB3 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
LRIG1 ERBB4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15282549 20126551 15345710
ERBB4 HDAC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31980649 20029029
ESR1 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
ESR1 STAT1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 25303530
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
LRIG1 MET â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24828152 17178829
MET PLCG1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 7513258 24728074 8662733
MYC TBP â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15723054 16713569 8755740
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
NRG1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 7514177
IGF1R PIK3R3 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
MAPK1 SHC1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
LMNA SREBF1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
TP53 WT1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
PIK3R2 TGFBR2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
GAB1 LCK â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24728074 34079125
GAB1 RASA1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24728074 15574420
EPS15 AP2S1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 19380743
CEBPB CEBPD â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 1840554 20102225
EGFR HGS â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR STAT3 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 22693070
EMD LMNB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17620012 34079125 12670476
MATK ERBB2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12122014 16273093 9461599
HCK PIK3CB â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
LAMC1 LAMB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17517882
S100A4 TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR SH3KBP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CALM1 EGFR â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CTNND1 EGFR â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDKN1A STAT3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ERBB2 ERBB4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
GRB2 STAMBP â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
LMNA PIK3R3 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
MAP3K1 MAPK1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EGFR HBEGF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EGFR USP8 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PTPN1 SRC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
EGFR STAT1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
FLT4 KDR â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PIK3R1 SHC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR SH3GL2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
GAB1 MET â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
PTPN1 IGF1R â—¼   DEPHOSPHORYLATION ✅ - 0.87 0.87 Signor 11884589
PDGFRB PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 7535778
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
ABI1 EPS8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
SHC1 EPS8 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 7791787 16189514
SOS1 EPS8 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10499589 16520382 14565974 27629044
EPS8 SRC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10395945 16189514
JUNB JUND â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442
EGFR AP2A1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31959764 24797263 23956138 25754235 20029029 24189400 7534311
CEBPB EGR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 22260630 12947119
PTK6 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16273093 8940083 22973453
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
EPS15 GRB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 17474147 7797522 19109251
LRIG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15282549 20126551 23723069 15345710
ERBB2 PTK6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20700126 18719096 22973453
PTK6 ERBB3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11114724 16273093 22973453
SRC ESR2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11032808 12630920 15604093 11013076 12095943
JAK1 GRB2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8536716 11527382
HCK RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 7782336 16189514
JUN STAT3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10490649 16713569
PAX6 TBP â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10359315 16713569
SRC RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11389730 16189514 16713569 1717825
TBP TP53 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CAV1 EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EGFR STAT5A â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CBL PLCG1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EGFR EPS15 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
STAT1 STAT3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
ERBB3 PIK3R2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
HSP90AA1 TERT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PDGFRB RASA1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
SRC STAT3 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EGFR PIK3R2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ERBB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CDH1 CTNNA1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
IGF1R SHC1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
PDGFRB SRC â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ATM LAMA1 â—¼   KO_UP_REGULATES ✅ + 0.88 0.88 PKG 28854368
CBL LCK â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EPS15 HGS â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
SH3GL2 SH3KBP1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CBL SHC1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL PIK3R2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
JAK1 STAT3 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
PTPN12 SHC1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
FOSL1 JUND â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26258633 24029232
ANXA1 EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24189400 31980649 15581623 20029029
EPS15 AP2A1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 8662627 9049247 10764745 19380743 10953014
SRC CAV1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 8632005 8910575 8621645 29720121
EGFR CDC37 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 23956138 24189400 12471035
LRIG1 EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15282549 16847455 15345710 20126551 18542056
EREG EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28988771 9419975
EGFR FGR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
TBP ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11595744 31527615 16713569 9259327
JUN ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17317669 16713569 23747343 11477071
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
TBP JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7685215 7848298 16055710 16713569
KDR SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
SHC1 MET â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7731718 24728074 9660480
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
TGFBR2 TGFB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8044119 21054789
EGFR GAB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
LAMB3 LAMC2 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
EGFR PIK3R1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CALM1 SLC9A1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CTNND1 ZBTB33 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
EGFR PTPN1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
FGFR2 GRB2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
EGFR RASA1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
LMNA LMNB1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ERBB4 GRB2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
EPS8 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 11408594 31980649 12127568 25402006 7532293
DIAPH1 BTC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PIK3R1 BTC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
BTC RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
BTC PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
BTC PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
JUND TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16135795 24872589 18078517
JUND MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1527086 18071306 22493372
PIK3CD GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CB GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
STAT5A IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8683106 9831114 7796811
CALM1 GRK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11042191 8910504 9753452
MAPK3 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21419341
SRC ADAM12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11127814
ADAM17 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9774383 12535668
ADAM17 HBEGF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16054021 26284334 18372913
ANXA1 UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AP2A1 EPS15 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
AP2A2 SHC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31980649 16713569 8617812 24189400 19380743 16189514
AP2S1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12577067
MYC APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
STAT1 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19508864 9841227
TBP APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8015372
EGR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15517885 12890669
AR PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11676474 20610535 11745419
AR CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18794357 20610535
AR TBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 9238003
AR MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20610535 20946682 17283128
AR PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22740037 12063252 20610535
AR PTPN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22282656 20610535
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
MYC ARF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
MYC BLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
EGFR CAV1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19446582 15657067 24658140 31980649 22411794 34079125 16407214 12354760 25402006 10781609 9374534 12388423 16799092 15273741
CAV1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23634843 11563984 22230296 19595769
ETV4 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15138262 19483189 17390339
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
MYC CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10918582 18444242 11258956
CAV1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10066366 11168929 23331499
CAV1 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20462514 12529448 19923922
SRC CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22203672 29899407 17141222 18996392 12941616 15135048 18273061 10829062 31120930 19861161 7782294 16713569 8635998 11994282 17094785 16636290
HCK CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10092522 11896602 8995358 22974441 10799548 11239464 11994282 9890970
EGFR CBL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23158001 24797263 25872741 31182136 10635327 26055326 14505571 15210722 32714745 23774213 19155296 11370743 19836242 8665853 19947936 18271526 25140053 15668240 22394513 17486068 33323455 32377695 22203672 17182860 12604776 14627991 15383614 23153581 15735736 28541302 16849543 17242169 20562913 32904620 9121472 15677445 7782294 16923119 17995934 19531499 15465819 31959764 32114396 23457600 29629558 18316398 23799367 24714105 31120930 12061819 16713569 7657591 33617900 10086340 19225046 33762435 23175185 16729043 28791635 16246327 28198003 15962011 22266821 15117950 27059931 10428778 12734385 8662998 25005938 27903975 16969069 26177020 8798643 10799548 9756944 15159412 19578043 15657067 18255265 23418353 25754235 22976291 17545148 12803489 18319245 19713535 7592693 30544639 15107835 11994282 17971399 16105874 15282549 20940296 23897813 9130710 18273061 18508924 17880946 20124286 12593795 16914641 20877636 10092522 25521828 11408594 22591401 9890970 20308550 22833562 21772844 33627783 11239464
CBL PPP2CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
CBL PPP2R1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
PTPN6 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11157475 12176909
LRIG1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15282549 23331499
CBL IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18632619 17635922 10514377
CBL PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 17635922 10514377
CBLB PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11087752 17635922 10514377
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
CDC37 SRC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 32707033 31980649 11085988
CDC37 MTOR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
NRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
WT1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23298185 23945386 10753894
CDH1 PIP5K1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22375065 17261850 22850631
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
CDKN1A UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A DDAH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
NR4A1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19584258
CEBPB FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8183933 12184911 21562223
CEBPB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21098707 20581311 16585579
MYC CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21143913 20426839 17471507
PPP2CA CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8864841 20133759 11093160
DDAH2 RPS6KA5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EREG DIAPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 EGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 MEMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 NRG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 ERBB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
DIAPH1 NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
NR4A1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12947120 24706823
E2F1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24755270
E2F1 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303924
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
E2F1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19276347 21625432
E2F1 MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10567569 8137237 18319725
EGF RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGF PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8940074 1672440 10473558
RELA EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15964798 21912613 23383347
STAT5A EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18996136 12697691 21617857
EGF PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
EGF PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17496910 1334406 19531499
EGF STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28542650 19168569 22162832
EGF PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23613900 17081983 16525023
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23436906 10527633 27756321 21278786 18803307 17148612 22439932 25315821 10572067 24189400 23866081
PTPN1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 6671413 9355745
TGFA EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12297049 24658140 31980649 8663070 10775655 25402006 28988771
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
JUNB EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10803405 23455325
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
STAT3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18367518 21590492 23504318
YY1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22580610 18391986
PTPN1 EGFR â—¼   PHOSPHORYLATION ✅ 0.9 0.9 mint 6671413 9355745
PTPN1 EGFR â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 6732094 9050838
EGFR PTPN1 â—¼   COLOCALIZATION ✅ 0.9 0.9 mint 25796184
EGFR PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
YES1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 22430206 11160627
EGFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8524316 15284024
EGR1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9053449 10671503
EGR1 KLF5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15098654 11795310 10865841
EGR1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7559553
EPAS1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15192019 18625704 19616846
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 19704002 21075308 7542762 7797556 19372587 29720121 11940572 17875712
PLCG1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 16273093 1683701 1676673
SHC1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30898150 10085134 9019162 24658140 22973453 16729043 9710588 28065597 16843263 9756944 16713569 16273093 8665853
ERBB2 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
YY1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19435870 18218085 15870067
MYB ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2577338 7721862
PTPN18 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25081058 14660651
ERBB2 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 17496910
SHC1 ERBB3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11546794 9019162 24658140 22973453 16729043 24189400 9756944 9694850 16273093 16189514 8665853
ERBB3 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
ERBB3 PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
EREG ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16829981 22891299 32196115
LRIG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16123311
RHOA ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PIK3CA ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3R1 ERBB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PTPN12 ERBB4 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
LRIG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16123311
EREG PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
EREG PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
EREG RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EREG PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
SHC1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20935677 11773443 16713569
ESR2 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19022902 19746436 10706629 12630920 9473491 21182203 29509190 17991765
SRC ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17043237 17284441 17400812 15604093 11032808 17921256 18451880 15020686 12736255 11564893 23065768 10454579 20935677 17363140 16957778 14963108 11013076 29720121 15784253 24498420 17627277 12630920 22328528 14766010 24051437 7539106 27420286 15140878
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
ESR1 TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12459033
NR0B1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11053406
STAT3 ESR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23295773 21546410
ESR2 HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
NR0B1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11053406
ETS2 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19411629 12438253
ETV4 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21184241 14988020
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
TBP FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22848139 7667110 1538403
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
MYC FOSL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
PDGFRA GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
PIK3CD GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
MET GRB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9660480 11439336 8662889 19433454 15546961 11063574 7511210 21222362
PIK3CB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
JAK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8536716 11527382
RASA1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12441060 16713569
TBP HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7567458 8370527 1559609
PIK3R1 HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3CA HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
RHOA HBEGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PTPN12 HBEGF â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
HIF1A MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20631454 19285046 19950212
HIF1A S100A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19637235
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
MYB IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10465027 19427836 23675407
LAMA5 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMC1 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMB1 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
ITGA6 LAMB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMA5 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10671376 11733063 32196115
LAMC1 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMB1 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMA5 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
ITGB4 LAMB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMB2 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7721947 10671376 32196115
LAMA5 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10671376 11733063 32196115
LAMB3 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12867433 8143784 32196115
LAMA3 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12867433 8143784 32196115
STAT3 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10497240 17204573 9325164
SRC KDR â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
SRC KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30644389 26854235 9096340
SOS1 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25624485 23331499 16293107
MYC LAMB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
LCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7682059 17570479 1500851
LMNB1 LMNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 21346760 32814053 25948554 11792809 31467278 34079125 19727227 24623722 30419336 21988832 22412018 26524528 26264872 29568061 16189514 29997244 30021884
MYC LMNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PPP2CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
RHOA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK1 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
MAPK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18378670 7569900 14963018
PPP2CA MAPK3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15930121
MAPK3 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
RHOA MEMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
SRC MET â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24728074 9837958 20624308 24034250
MYC MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
RELA MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19530226 20186924
PTPN2 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18819921
WT1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7559553
YY1 MYC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 18490439 19219071 2191300
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
STAT5A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17927978 12048235 12967477
WT1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15286719 17634147 20842112
MYC PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20123981 17382917 22550094
MYC RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22159222 20383141 22235332
MYC TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
NFKB1 STAT3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25241761 12057007 16713569
NFKB1 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
NFKB1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11689575 17407600 20352621
RELA NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20018891
RHOA NRG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
NRG1 PTPN12 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
PTPN12 NRG4 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 21376233 7542744 7541030
PIK3CA NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
RHOA NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
PIK3R1 NRG4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3R2 PDGFRA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFRA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
PDGFRA PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFRB PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFRB PTPN12 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 12614164 0265574 8312067
PDGFRB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
PDGFRB PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFRB PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17496910 16189514 11172806
SHC1 PIK3CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
SHC1 PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3CB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
PIK3CD SHC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3R2 SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
TGFBR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9435577
SRC PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 22402981
SRC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
SRC PPP2CA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
SRC PPP2R1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
STAT3 PTK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12540842 20929863 19393627
PTPN6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18508557 15870198 10545526
RELA WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
RELA SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18477483 19538137 17665043
STAT1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16481475
SREBF1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11875060 19048273 22031849
STAT1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24655378 14602726
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
STAT5A TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402124 21356308 17525530
FOSL1 JUN â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
AP2A2 EPS15 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
EGFR SOS1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
GAB1 PIK3R1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
LAMA5 LAMB1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
ERBB2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
CBL MET â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
ERBB3 PIK3R1 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
MAPK1 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
PPP2R2A PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 20711181 8288198
FLT4 SHC1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
KDR SHC1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
SHC1 SOS1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
CBLB SH3KBP1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
ERBB3 SHC1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
EPN1 EPS15 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
ERBB4 SHC1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ERBB3 NRG1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
FYN CDC37 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 25036637 31980649 28514442 32707033
EGFR PLCG1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
PIK3R1 ERBB3 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 JUND â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.92 PKG 28854368
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
ERBB2 SHC1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
PDGFRB PIK3R1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
CBL SH3KBP1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CEBPB MYB â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CDH1 CTNND1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
TP53 TF â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.92 PKG 28854368
SRC CTNND1 â—¼   PHOSPHORYLATION ✅ + 0.93 0.93 Signor 11382764
EGFR EPGN â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EGFR STAT3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
PIK3R1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5217342 15556646
SH3KBP1 CBLB â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 6170278 12177062
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
JUN JUNB â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 25609649 28514442 33961781
SRC PTPN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 6672195 16115959
SRC PTPN1 â—¼   PHOSPHORYLATION ✅ 0.94 0.94 mint 6732073 9600099
SRC PTPN1 â—¼   DEPHOSPHORYLATION ✅ 0.94 0.94 mint 11007774 6671922
PTPN1 SRC â—¼   DEPHOSPHORYLATION ✅ 0.94 0.94 mint 6764906 16537444
PIK3CA PIK3R3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
FYN YES1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CBLB UBE2D2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ERBB3 GRB2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
MET GAB1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 9242692 10871282 10995442 10734310 10913131
ABI1 SOS1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 10499589 15289329
AP2A1 SHC1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 33961781 31980649 8617812 11302736 28514442 24189400 19380743 16189514
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
SOS1 FYN â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 17474147 16713569 9856337
PIK3R1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7536927 6730373
PPP2R2A PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17245430 5219546
EPN1 KDR â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CBLB EGFR â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
IGF1R PTPN1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CBLB GRB2 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
GAB1 PLCG1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 24728074 8596638 11507676
SHC1 CBL â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 9234717 9541596 15677445 8621719 16713569 8950973 10025673 10570290 8662998 19380743 9461587 9434624
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
SOS1 EGFR â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 19531499 18271526 31959764 24797263 7510700 20473329 19289468 10675333 23956138 25754235 8621459 16713569 26005835 9447973
ERBB4 ERBB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 24557338 30898150 8816440 16767099 25315821 10572067 10839362 21203579
JUNB FOSL1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 32296183 23661758 24029232 16189514 12371906
PLCG1 GRB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 21706016 7629168 10940929 16038803 9020117 16713569 9281317 7516467
SOS1 PLCG1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 10913276 10940929 9020117 16713569 17474147
FGFR2 PLCG1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
LAMA5 LAMC1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
EPS15 EPN1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10791968 18375383 18200045 15809337 9723620 21115825 16429130
EPN1 AP2A2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 12057195 9723620
SH3KBP1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6170483 15090612
FYN CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9677430 8621719 12244174 7782294 10629042 119942 7642581 15556646 12231245 9311917 9535867 8626543 10799548 16713569 16503409 10092522 8900205 8995358 25814554 9890970 15190072 15208330 12941616 10829062 11239464 8662998 17094785
PLCG1 CBL â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9234717 12941616 25241761 16467851 12061819 9712732 16713569 16503409 17372230 12803489
EGFR EGF â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 25453753 30083275 21822280 12620237 19531499 25080504 12093292 22729867 23597562 18427122 26280537 18271526 10970856 15620700 11684674 21439278 8663535 28988771 2790960 10788520 10085134 16274239 25241761 17697999 9135143 12297050
SHC1 EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10595738 24797263 24658140 7542744 21278788 9130710 28065597 10766863 10635327 8034616 24430869 7518560 12577067 19531499 31959764 8810340 9742218 11196191 23799367 23956138 9756944 16713569 11370743 8665853 18271526 15657067 11408594 20473329 22973453 16729043 20935677 20067773 7506413 16273093 25754235 8610109 24189400 26551075 9388490 8887653 31980649 7542991 9544989 9020193 25187647 25402006 30544639 10049786 8662998
SRC EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22227249 17284441 24658140 17158602 21278788 20333651 28065597 7527393 7797556 10777553 16713569 20624308 23175185 7506422 22973453 20935677 24189400 11983694 10075741 31980649 19704002 10358079 10971656 21268077 9020193 25402006 21573184 8845374
EGFR EREG â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22806884 25898135 30523157 9130710 21278786 15812817 20227043 16843263 10572067 19411071 19060928 8665853 10799311 8816440 17426253 17148612 21075308 12896906 15504738 23680147 23688700 23866081 22733765 7592681 21203579 25326665 24557338 23436906 30898150 7538656 25241761 25315821 11173924
NCOA2 ESR1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 12837248 17697320 11014206 12554772 18499756 15657427 11265755 9430642 11376110 9774463 16645043 9192892 11937504 26487511 12612084 19460354 20348541 11250900 12630920 12714702 14766010
JUN FOSL1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11912197 33961781 11431474 11708771 23661758 9160889 24029232 20511396 26258633
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
SRC SHC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9388490 18840094 9710204 10482988 9096689 7499252 8939605 26551075 16189514
AP2A1 AP2S1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
LAMB1 LAMC1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EGFR TGFA â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
EMD LMNA â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
AR NCOA2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
PDGFRB PLCG1 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
TGFBR1 TGFBR2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CBL UBE2D2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
FLT1 KDR â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
EGF EGFR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
PIK3CD PIK3R1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ESR1 NCOA2 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
EPS15 AP2A2 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 10809762 18362181 8662627 9049247 26822536 19380743
SHC1 GRB2 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 12213123 8491186 8950973 9927207 9733714 8112292 10356320 11370743 32062451 8294403 16371368 22057045 9045692 9032244 8995379 7514169 9175774 9541596 8663178 7629070 9019162 7597091 7798267 9544989 9488479 8940013 10570290 15812354 11792427 8621719 24430869 7650032 11453982 16713569 7516467 10477741 8662733 11302736 26551075 9254595 7559490 12441060 8662998 8235613 12485888 28690151 16520382 8939605 11505033 9129019 11707405 15888547 8647288 7524086 25416956 24189400 11827484 12149229 8195171 21725358 9020193 10049786 9797459 9886492 33961781 9126968 8626525 7537740 12577067 11964172 12898421 8810340 22974441 19380743 9434624 10080542 9083103 21706016 15688026 7535773 31980649 8561895 7744881
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
AP2A2 AP2S1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EGFR SHC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
HBA1 HBB â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R2A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CBL PIK3R1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
USP6NL EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8700527 11099046
PTK6 EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28214294 27738316
EGFR EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 31980649 11408594 8404850 7532293 24658140 12127568 25402006
SRC EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23626693 16189514 10395945 32641864
EGFR CALM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 19901323 20029029 16497976 15592455 25402006 17389395 18578522 16799092 20068231 7925415 3415247 8639568 18669648 12153558 24658140 17287340 2843348 14960328 18707149 17016520
SHC1 BTC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
HSP90AA1 BTC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
BTC ERBIN â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
BTC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10209155 14967450 23382875 8144591 24440602 9528863
BTC ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 8570211 10209155 10214951 22232668 11254912 16829981
EGFR CALM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 19901323 20029029 16497976 15592455 25402006 17389395 18578522 16799092 20068231 7925415 3415247 8639568 18669648 12153558 24658140 17287340 2843348 14960328 15212693 18707149 17016520
ESR1 JUND â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 25542856 18219272 3677090 20219941 23145106 1630819 3045126 15514030 24854081 22265404 17013392 21835891 9671459 21940756
JUND NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7969116 10567637 11719525 16264271
JUND FOSL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23319049 13679379
JUND TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19211927 16896927 21515915 10843986
MAPK1 JUND â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17570479 22327296 14676207
MAPK3 JUND â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22327296 14676207
EPS15 EPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16429130 18375383 35044719 9723620 10393179 18200045 15809337 21115825 10791968
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
FGFR2 GAB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
HSP90AA1 GAB1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
GAB1 CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
MET GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10978177 17389395 19901323 10753869 15574420 15212693 10913131 10734310 11896055 20068231 10995442 9890893 16497976 14685170 17016520 18669648 11779868
EGFR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 19901323 15231819 16497976 25402006 17389395 20068231 23066441 11432805 9658397 19509291 18669648 10978177 10753869 10734310 11896055 18271526 24658140 10648629 11779868 31980649 15212693 9890893 17016520
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
SHC1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11707404 14982882 24728074 10871282 10194437 9804835 12808090
MAPK3 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12008033 15379552
MAPK1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12008033 26538579 15379552 10593929
SRC GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26706435 15574420 19881549 12941962 21442024 12808090
GAB1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8596638 23331499 11507676 24728074 10871282
GAB1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 10978177 11940581 8596638 24728074 9891995 16638574 9658397 9804835 11606067 9632795
GAB1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11043767 8596638 11278704 10194437 10592173
RELA IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7957928 15331713 9446577 8035474
NFKB1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7957928 15331713 8035474
STAT1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11244574 9325014 11909852 15714000 1833631 14978477 12356687 8454630 17617740 20585034 22589541 8683106 1756724 22252317 11566724 11591697 11972347 18616672 19135978 8509377 10586107 20526365 15664995 8444884 17050680 18562017 7796811 18778729 1315834 17374731 22479354 10406469 21659501 8805641 18024894 19561067 8034722 15467722 23598529 17689680 12748307
MAPK3 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 19651622 18767875 23772028 18088087 10574913 10727525
SRC GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12624098 16725308 11278940 11566877 16189514
GRK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15116093 20473327 23723076 18952844 15053879 10933801 33256128 11409876 20124405 29988038 14729628
ERBB4 ERBIN â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
EREG ERBIN â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
NRG1 ERBIN â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
ERBB3 ERBIN â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
NRG4 ERBIN â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
ERBIN HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
MAPK1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19917258 17855441 21419341 21900237
ABI1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17395426 18594017
ADAM10 ADAM17 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
HIF1A ADAM10 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
ADAM10 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12651094 23331499 19726682 19704010 19601831
ADAM10 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 32814053 30538620 12535668
MAPK3 ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12058067 18187448 21570469
ADAM17 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15534001 15746097 10744726 9685416 26554003 17486069
EGFR ANXA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15581623 31980649 3020049 24782913 2457390 24189400 9223619 17081983 20029029 16052208 22792315 24103589
SRC ANXA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24103589 17570479 2457390
AP2A1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 12577067
JUN APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8063812 11677255 8015372
TGFB1 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12867422 25241761 16189514 2119582
NFKB1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14576180 15517885 20159994 12165860 16619263
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
E2F1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21966451 17178887 22508987 21099110 21099103
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
AR EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18511414 8580999 7522959 15590903 14662770 18692155 17374439 18212060 20610535
AR EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15305378 19318561 21613411 19258514 15650253 17242169 18692155 15288768 11556855 20610535
AR SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19305643 10454563 18687691 17108144 17079466
AR IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19318566 15033751 17202144 19250214 20610535
AR UBE2D3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
AR KLF5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19460858 20610535
NCOA2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9717843 12588987 15684378 14593076 24239470 15563469 18780293 12810069 16713569 10601285 14966121 10935543 10454556
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
UBE2I AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
NR0B1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11875111 21071413 12771131 16713569 18988627
SRC AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 28144231 15062576 20570899 25133482 21318111 11032808 25950519 21512132 17525795 12933816 20383201 24728074 24948875 24868554 25547388 19117998 21956655 17045208 15027889 24859991 15466214 26829214 21886458
AR JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11577103 11518798 9211894 8798722 16713569 9591784 17721441
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
AR UBE2I â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10383460 8798622 19692572 12764129
AR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18358509 12534934 22260327 15288768 18951974
EGFR ARF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12446727
PPP2CA ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15510216
ATM SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22588298 23277204
ATM HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27245613 24681585 21095578 18971907 21095582 27027353 23573973 27068951 25956861 23707302 26942179
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
BLK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8621719 8083187
BLK EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 31980649 16273093 24658140 11160627 25402006
KRAS CALM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 27410739 12727204 28666118 16043511
EGFR CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17145710 19901323 20029029 12359306 16497976 25402006 17389395 18578522 16799092 20068231 3415247 7925415 18669648 12153558 24658140 17287340 14960328 18707149 17016520
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
HIF1A CAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
CAV1 TGFBR1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
CAV1 SRC â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
CAV1 EGFR â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
CAV1 TGFBR2 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
FYN CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 9252391 29371975 11805080 12925753 21705803 12529448 11075810 15692085 14992595 8632005 10592173 16943184 12921535 16332692 12135605 20228056 15466865 33804982 24632723 33928090 18347068 34321069
SRC CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 20201820 23469926 24755228 24525631 15592455 27259249 17979878 19409422 11075810 17389395 14992595 18578522 11094059 11451957 24244013 8632005 24131997 12921535 21324536 16332692 8621645 18815812 27170175 17517963 12531427 24632723 23091071 19625610 18789131 24502576 17016520 20107068 21382479 24364863 25937636 19604397 23280667 16713182 22596063 26169283 8910575 17190831 18707149 25097454 12036959 18176934 15212693 18400052
EGFR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 31980649 22411794 9374534 19446582 16799092 12388423 15657067 24658140 19625610 16407214 18789131 25402006 15951569 10781609 16332692
PTPN1 CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16388599 12176037 16189514
CAV1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18988627 16189514 10066366
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
GRB2 CBL â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 25036637 25872741 8950973 917890 7642581 17944804 15210722 9108392 20936779 8695851 19836242 14725908 169092 28514442 9541596 9174058 11823423 12941616 10829062 10570290 7544353 11792427 8083187 15677445 8621719 9233773 9311917 23799367 16713569 10086340 9234717 8995358 25814554 9716598 11997436 7791764 8943292 8063801 8995445 8662998 11263968 16906159 8626404 9129019 98621719 17072306 9242692 10521482 9872323 8647120 7592693 9092538 10025673 17971399 17094785 9851874 11399323 33961781 9259313 18273061 7537740 8649804 9295052 11964172 9367879 20124286 10204582 19380743 9434624 21706016 8900205 9178909 12839496 9461587 31980649 11133830 33627783 8824292 8621483
HGS CBL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
PIK3CD CBL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
EGF CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CBL CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
SH3KBP1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 20130058 20711168 12618476 11894095 16407834 16713569 11071869 19268472 25472714 17306257 22262777 15456872 11152963 10679202 15962011 25036637 15107835 22833562 11067845 11894096 12177062 17675467 21830225 12135478 24167568 16228008 12874286 17072306 15090612 14596919
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
YES1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10092522 11994282 11997497 12522270 9525940 12604776 9890970 9102067 10829062 10799548 11239464 10934191
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
HCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 10092522 11994282 9525940 8995358 12604776 9890970 11896602 10799548 11239464 10934191
LCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 9525940 10829062 10799548 10934191 7721825 16107303 12604776 9890970 17570479 11904433 9178909 10092522 11997497 12522270 8621719 9102067 11239464 11994282 11741956
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9234717 10347229 18988627 17635922 10514377
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CBL FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25387128 18273061 17635922 10514377
CBL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 9092574 19190244 11406619 11133830 7629144 17635922 11526404 8662998 8995358 8080844 15107835 23109003 17722974 8621719 16107703 9414268 10514377 15790353 19531499 22315502 19380743 25814554 9461587
CBL MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16397241 15123609 23331499 25241761 21222362 11894096 18672314 21163258 19450681 18273061 35309168 17533376 19433454 17635922 10514377
CBL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7517397 9712732 12941616 25241761 12061819 23109003 9234717 16503409 11709089 16713569 17372230 16467851 12803489
CBL PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 8641358 9119889 19380743 8621719 7629144 17635922 10514377
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 98.0 1.0 Omnipath 9092574 19190244 16289966 11406619 7642581 11133830 10358153 8941725 9234717 8612729 11157475 10620516 16713569 21203488 11418612 24113870 17635922 18374639 14530346 11526404 8662998 8995358 11030146 9890970 9541596 11042121 15581361 9890943 8080844 7791764 9178909 15107835 8995243 8695807 9988765 23109003 11944898 15556646 17237826 10025673 17722974 8621719 16135792 16107703 16219545 9461587 9160881 9414268 16982329 19861161 10514377 9918857 11087752 9092538 11994282 9259313 15790353 19531499 9174058 8702998 25814554 22315502 19380743 10918571 8896416
CBLB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 19531499 11375397 10086340 12577067 10542134 17635922 10514377
CBLB SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19531499 11375397 16189514 9614102 12577067
CBLB PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11087752 21780115 10488096 19531499 11526404 15032589 23109003 22880054 17635922 10514377
CBLB FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15208330 16503409 32296183 25814554 8083187
CBLB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 10022120 25416956 21706016 31467278 32814053 9614102 17635922 11375397 8626404 16189514 21900206 20936779 27107012 12577067 10514377 19531499 10086340 29997244
CBLB PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 11087752 21780115 10488096 19531499 11526404 10086340 15032589 23109003 22880054 9614102 17635922 10514377
STAT5A CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11160217 12586844 14660677 15509806 22723377
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
CCND2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
NRG1 CDC37 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
ERBB4 CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
SHC1 CDC37 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
PLCG1 CDC37 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
EREG CDC37 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
CDC37 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
CDC37 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
MYC CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9632747 19176757 23364919 10523846
SNAI1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 71.0 1.0 Omnipath 16502042 16424022 18347060 19874710 23054398 11912130 12668723 21081648 24168186 20455091 16617148 19635798 24424621 15300012 22775504 12508111 25025961 23637992 20576520 24228088 18701475 20562920 22562246 23424071 21685935 15026811 24504364 18801366 19055748 18321996 17060462 23295740 22128911 23752226 24293287 16273209 19893985 18385519 23671646 17724139 24305977 20801642 10655587 15492833 19789323 21846773 19784072 17082242 17671186 22911555 14673164 16804902 17490644 23658826 18519590 12579345 22158034 17655524 24095903 18565826 20053763 15311212 15448698 19179606 12161443 22614005 18773488 21796367 24448241 16322400
ESR1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12726856 14500345 17893710 19383788 19593637 20101232
MET CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17496910 17336101 22558232 16909210 12040186 19568798 14585353
SNAI1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 11309385 17018611 22514743 19597490 14673164
CTNND1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 7542250 17261850 22752307 9535896 7651399 12707304 23180380 24424122 12640114 11226248 29207493 10225956 12427869 21670201 22850631 20371349 20940130 25468996 10409703 14610055 7876318 22715382 10629228 19711372 8660921 10931041
CDH1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 19029934 22370635 16099633 23343194 19734908 10744074 16039586 22203675 19171760 22007144 19619488 17143292
CDH1 CTNNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 7542250 19016843 25468996 9326449 16212417 11960376 11801604 8227214 10381631 16219695 9700170 24336504 22750944 9233779 11226248
CDH1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17548604 10969083 15662113 31980649 14681060 25241761 24189400 25468996 24658140 25402006
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
STAT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20738848 11162600 12239594 16449678 21307941 22591439 10023678 10866323
STAT3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23178160 19372587 15286705 18320073 15063116 16923815 9694869 22328012 12438313 11773079 20654581 10023678 19329556 21184768 11114718
CEBPB CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10982390 15466360 15041706
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
E2F1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9748148 9191053 16923815 17008321 10030670 10702805 15048076 17167174
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
TBP CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15280358 17130157 17996705
JUN CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11136975 12717415 21278055 10506225 19628677 12054510 18094076 10072388 18210215 10733944
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
EGR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18316600 20368687 19508870 24384380 17307334 11502738 12690110 21642427
WT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10224085 18202757 17160023
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
CDKN1A E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CDKN1A STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25241761 16189514 10764767
STAT3 CEBPB â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
CEBPD CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7646815 18703634 7910803 11559710 18092000 1741402
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11500490 18444174 16107878 10318842
CEBPB GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17129742 12213825 15860545 20228168 11414683 18180320 21292824 17110376 10531366
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
MAPK3 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 19327116 19443782 15212693 15367685
MAPK1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 21980398 19443782 17570479 19413330 19723873 15367685
CEBPB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11134330 18266962
STAT3 CEBPD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10867011 17471507 24011072 15389878 15486993 9163525 25787076 15930175 9528783 16293640
SRC CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19802004
ZBTB33 CTNND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21554891 15138284 24979278 21670201 20303951 12087177 15817151
PTPN6 CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10835420
SRC CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17389395 11382764 19138410 20068231 18707149 17194753 23457577 26477567 14996911 17016520 18669648
MET CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
FYN CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 26477567 11777936 17194753
EGFR CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 17145710 22558232 18950621 23481205 25402006 12040186 24797263 9535896 17389395 20068231 19568798 27316454 14585353 17496910 24189400 15657067 24658140 31980649 26067913 15951569 14996911 17016520
ERBB2 CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
CTNND1 ZBTB33 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22276175 15548582 24498333 19615783 21670201 10207085 20382170 15564377
RHOA DIAPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22820501 12773565 18218625 16109481 15864301
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
E2F1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10567569 7929342 7565760 15867358 16299810 8137237
E2F1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21411498 22654424 18818403 11433024 19358274 22207128 16264179 12368233
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
RELA EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21334436 10969841 18226221
JUN EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740983 1918021 22301113 21239258 12208352 21216243
HIF1A EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19783678 11352889 18411415 17431122 12023962 11278891
HIF1A EDN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 16716598 12829734 9159130 13130303 9588211 12080085 11566883 10403805 9746763 8943284 15451019 9278421 16887934
EDN1 EDNRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 90829707 6479761 9082970 7509919 16597412 16713569 23597562 15629009 8440682 7647976 10770212
EGF MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
TGFBR1 EGF â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16424049 16474430 16572188 17070508 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26201938 26966341 2871107 7594497 8515656
TGFBR2 EGF â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16424049 16474430 16572188 17070508 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26201938 26966341 2871107 7594497 8515656
EGF EGFR â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
EGF PLAU â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
EGF RHOA â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
JUN EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15075211 15772294 19937979 15375216 10617690 18625220 15238218 7629150 8885243 12954631 10973489 16214953 14518567
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
EGR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22198386 22593802 19913601 10395376 18844239 22433566 20472833 24470481
EGF GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17081983 19531499 17673906 10973965
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
EGF SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23349873 19481075 15845350 22927910 27462789
EGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 131.0 1.0 Omnipath 17145710 17081983 21822280 20813200 23613900 9135143 25453753 21303971 10209155 26821125 12297050 27387652 25241761 30083275 12093292 30197274 21649524 19531499 18762250 16729043 26921391 17697999 17575160 21722395 12620237 19129184 10788520 23331499 3494473 15620700 14568001 15958209 24096486 18253097 16843263 18320059 21532939 10085134 22260327 15708576 26280537 23912460 21858221 11116185 10970856 27462018 18427122 25080504 20953304 19135477 11684674 8639530 27564112 18270696 2790960 17971399 23185569 19895983 28988771 29617357 23597562 19531623 23950932 21071413 8663535 6289330 16274239 17563729 21439278 20458382 22216880 18271526 12771140 21311755 24709886 25366117 12648462 21107857
EGFR MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
EGFR SHC1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
WT1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19014381 8827073 19321755 20944147 11071895 9291179 7588596
TP53 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20190820 18359760 9664135 10029407 8152794 11713584 8887630 9285564 19597475 11546792 1586628 18604200 18391986
NFKB1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14678988 18367518 12469217 17881446
EGR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16750517 15863471 23763269 16170359 11830539 17230532
HCK EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 31980649 24658140 11160627 25402006 23397142
EREG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9419975 36202915 20513444 28988771 8626392
TGFA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 21722395 28988771 25402006 23155381 3018723 23331499 16585207 10209155 24658140 10775655 31980649 12297049 8663070 12648464 27635238
PTPN2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15592458 15588985 9488479 10488121 11514572 11479308
PPP2CA EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
HBEGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22529914 12097488 23331499 28943431 30071291 10209155 9135143 23888518 14967450 28988771 29274275 19531065 12621152 12725245
FGR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 31980649 24658140 11160627 25402006
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
USP8 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16520378 16120644 25853104 20736164
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
TGFB1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20953304 32103204 19132220 28943431
EPGN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27298358 28988771 20513444
MAPK3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 1651322 17081983 3138233 15901825 16785992 1939237 91332050 27531070 17570479 2543683 2115882 34086370 17192257 1651323 15302935
PTPN6 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 9038217 9287352 7673163 7518460 9733788
EGFR PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17496910 31980649 25241761 16273093 24658140 25402006
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23956138 12070153 20145033 14967450 20032199 21573184 25402006 10358079 23894143 14966128 24135280 25241761 14963038 24189400 15657067 24658140 15485908 15950906 18258752 31980649 9756944 22693070 12873986 15951569 15284024
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9544989 19531499 9447973 16713569 12577067
EGFR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 78.0 1.0 Omnipath 9544989 8808684 10595738 23956138 9388490 11350724 16273093 7542991 7681824 7518560 9710588 23799367 16713569 25402006 11370743 24797263 9742218 20935677 8887653 8034616 23331499 8662998 7542744 10049786 28065597 9130710 10635327 24189400 7506413 18271526 15657067 24658140 8810340 12577067 11196191 10766863 23178716 31980649 35384245 11408594 19531499 9756944 26551075 1623525 15951569 16729043 17956904
EGFR EPS15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17145710 17389395 10953014 24269888 19534553 25260758 19583965 19690332 15951569 9049247 17016520
EGFR RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8647858 16273093 7991458 1850098 17570479 1633149 1385407
EGFR STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 31980649 10358079 24658140 25402006 18586824 16729043
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR PTPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 25796184 31980649 8621392 12573287 18253097 11106648 11506178 24658140 7540771 9050838 9355745 15982634 25402006 10889023 7693694 8999839
EGFR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17496910 31980649 23956138 19531499 16273093 24658140 11172806 1334406 25402006
EGFR LRIG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15282549 23331499 15345710 21071413 18542056
EGFR STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 23956138 12070153 11839738 10918587 11447289 11997436 14967450 25402006 12040186 24797263 15173823 7543024 15322115 10358079 6321473 11294897 7690989 10982844 19568798 12637327 14585353 15199124 17496910 11438544 10748192 24658140 7657660 12817007 31980649 22693070 9355737 19615955 11152457 15284024 15567848 7592750 16488589
EGFR HGS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12953068 17016520
EGFR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19901323 17081983 16273093 9207933 2472219 16497976 15592455 16126727 16713569 24797263 17389395 8578591 23331499 7991458 1689310 20068231 17570479 9176240 12803489 16153436 7993895 16038803 7805859 15864276 1708307 7682059 15144186 11983899 12601080 9756944 15212693 14568990 12061819 9020117 8885868 12648464 8657103 15951569 17016520 7693694
EGFR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17496910 26918608 7797556 25241761 19531499 16273093 8662998 14967450 16713569 21701776
EGFR HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20133936 31980649 22896792 20029029 24658140 21151618 25402006 23084749
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
RELA EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19276347 20427719 15616591 21983014
EGR1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10669633 10828020
EGR1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18506761 20448047
EGR1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20621662 10982796 12237943
EGR1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17916653 20417179 8794351 8058069 8051207 26279418 10783396 16138117 8876223 20690147 16702209 11707452
EGR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9242687 17822668 15958557 12755686 16990849
RELA EGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19915002 19837667 10671503
EGR1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15225550 14744935 11251186 16713569 12384981
SRC EMD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 25008017 24609268 19789182 29684168 24365856 17637040
UBE2D3 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D2 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
MET EPS15 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
EPS15 SH3KBP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
EPS15 SH3GL2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
EPS15 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7797522 17474147 19109251
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
NRG1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12082616 8651595 10768865 12471041 12374700
ETV4 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11175365 18409049 10655108 16406575 7914192 16786139 17168666 15235125 15461591 11774202 16632435
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
LRIG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15282549 23331499 15345710 23723069 16123311
TGFA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10918572
NRG1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9275162 1350381 19293191 14737100 7514177
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
ERBB2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 17496910 11546794 23331499 9756944 16273093 1351056 15680399 11331299 21075308 16843263
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
ERBB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 16273093 1676673 1683701
ERBB2 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16273093 24412244
ERBB2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 28065597 23331499 9756944 16273093 8026468 9710588 10085134 24658140 9590694 16713569 16729043 16843263
ERBB2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 10839362 8816440 24557338 16767099 21203579 10572067
ERBB2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 16273093 1334406 16729043
HSP90AA1 ERBB3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
ERBB3 MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
NRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRG1 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10970856 16843264 7514177 7592681 23331499 8702572 7477375 11555649 9565587 16189514 26148232 9168115 9275162 10214951 17697999
ERBB3 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16273093 17496910 24189400
ERBB3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9694850 9756944 16273093 24189400 8026468 24658140 9590694 16189514 16729043
ERBB3 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 16273093 24189400 16729043
ERBB3 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 17145710 18803287 16273093 23331499 21278786 21071413 11694521 18988627 10383151 9130710 17496910 11546794 20227043 20007781 24189400 10572067 22439932 9756944 21075308
ERBB3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9756944 24189400 11173924 24658140 14967450 16729043
ERBB4 MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
NRG1 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 9275162 7721889 25052836 10970856 10214951 8062828 9565587 14967450 10537356 9168115
EREG ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9419975 16829981 22891299
HBEGF ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 1840698 23331499 10209155 9135143 12621152
NRG4 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 7477375 10348342 14967450 18988627
ERBB4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24658140 16829981 16729043 12731860 25140053
ERBB4 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15534001 10508857 15863494 16729043
ERBB4 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16273093 16729043 24658140
ERBB4 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16729043 17496910
EREG MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
EREG HSP90AA1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
EREG SHC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
STAT5A ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11731618 22201800 11682624 11682625
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 TGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11145955 8360257 11517191 10828826 22488924 18414489 9667651
ESR1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16574784 18006642
ESR1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21411498 12122114 21693539 18519947 16690106 10805720 19360348 23409030 18754863
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
ESR1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11477071 17963131 10037443 16679312
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
ESR1 FOSL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22514284 20034404
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
LCK ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9500442 10571988 25386784 11145737 7539106 27748765
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
JUN ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
ESR1 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18499756 9192892 9430642 11014206 19460354 15657427 23331499 11477071 26487511 16645043 12612084 20348541 12630920 14766010 17697320 11937504 12714702 12554772 9774463
ESR1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
ESR2 TGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22488924 11517191 14630090
ESR2 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12122114 10805720
ESR2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11013076 12095943 12630920 11032808
ETS2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
ETS2 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
MYC ETS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18586674 12695333
ETS2 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18586674 14611815 21763315 17986575
ETV4 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1330539 8570190 9295342 11676474 8761947 7760840
FGF5 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 838682811876253 16597617 8386828 11876253 25772309
FGF5 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16597617 83868288386828 8386828 25772309
FGFR1 PIK3CA â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17505008 18757403 21666749 11689702 21711248 11739186 21160078 14534538 15448205
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
TP53 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22466965 18811981 16557594 24492005
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
FGFR1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 11447289 19615955 16488589 6321473 11997436 12040186 19568798 15567848 15173823 14585353 15199124
FGFR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 18412956 25241761 15117958
FGFR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15117958
FGFR2 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FGFR2 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 11447289 19615955 16488589 6321473 11997436 12040186 19568798 15567848 15173823 14585353 15199124
FGFR2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22726438 19735729 26103942 20554525 23420874
FGFR2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12601080 17081983 7999363 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436 24440983
FGR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
FGR PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
FLT1 GRB2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 SHC1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 SHC1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 GRB2 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
TP53 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16432214 20080630 17242190 20422012
HIF1A FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
FLT1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 7657594 23397142 20805333
FLT1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9299537 23331499 9398617 9600074 11312102 18988627 23397142
KDR FLT4 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
SHC1 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
KDR FLT4 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
GRB2 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FLT4 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SRC FLT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16076871 12881528 20431062 18083107
FLT4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9927207 8662748 7675451 7970715
FLT4 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 9388490 7675451 9096689 15592455 9121430 9446569 10891441 11687594 23331499 10921922 10482988 10764799 12522270 9685404 10896916 9927207 8662748 8702728 12237775 8610109 9741627 9710204 10816433 11075717
JUN FOSL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18435914 15806162 13679379 17082637
FOSL1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16554298 22514284 22514348 15319566 17572495
JUN FOSL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9160889 11708771 23661758 20511396 11431474 24029232 11912197
PIK3CD FYN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9590251 7537740 8995358 9259313
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN SH3KBP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17350651 23052211 23506116 16529723
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN PAG1 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
KDR FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
PDGFRB FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 1696179 7685273 7687537 16713569 1661130 9425276
FYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7515100 1334406 16713569 1652056
FYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 16713569 9446569 17389395 23331499 18578522 10921922 10482988 10764799 18452278 20068231 10592173 18669648 12522270 9685404 10896916 7516469 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
FYN SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17474147 16713569 9856337
FYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8395016 10586033 7682059 16713569
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
POU1F1 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 89.0 1.0 Omnipath 19887646 22020338 12673394 8754847 9259323 8612514 7608249 7920986 2550324 17456792 19427323 1869051 10687855 10652292 7565785 11518797 10562456 16043966 8316253 7499395 1409723 7877625 2740217 7699993 7740167 7649093 9765286 10390158 9207961 2181288 8441408 9475179 8370519 16322098 2184776 9928036 8702932 22581457 2307370 7529501 1976240 22890843 2188653 22634956 17485162 11874696 11073444 12039061 8148036 19808898 24284820 9389530 15266826 16216912 12773133 2563596 9973253 8882721 11589626 16061841 8691106 16724305 8507204 8625613 9220025 1779974 19556346 16901973 1454833 8226986 12225774 2046665 16914737 2574416 8879985 7649480 15998782 10525051 8706656 18220741 12792149 1600947 9886052 20978111 1584227 22199144 2831625 2211620 11081207
STAT5A GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10674400 7744007 8732682 11092411 12683938 18388193 22698918 19819986 22166977 11564677 14532269 17412814 12970402 10373481 15677453 10803577
HGS GRB2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 8810325 33961781 8695800 7510700 8626525 34407391 16520382 10570290 16906159 16893902 7642581 8816480 9447984 12577067 11964172 8112292 8493579 7664271 16713569 7516467 19380743 9009162 10207103 17474147 10477741 32062451 7629138 21706016 20473329 19323566 9872323 32203420 7514169 21988832 28166272 28514442 9716598 11997436 9344843 15192046 10716926 8479541 14679214 8943292 31980649 7629168 7559490 9478994 7527391 8188688 11960376 10025673 11726515 7773779 10319320 9569023 9797459
STAT5A GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 SHC1 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 KDR â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 MAP3K1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10086337 10465784 10567412 10811803 10982827 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26552706 7510700 8551221 9379049 9582321
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 KDR â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 MAP3K1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10086337 10465784 10567412 10811803 10982827 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26552706 7510700 8551221 9379049 9582321
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
LCK GRB2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
JUN GRB2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
SPRY1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11447289 11997436 15173823 17496910
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
MET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9660480 15546961 22128289 12475979 11063574 7511210 11439336 8662889
PDGFRB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7935391 16713569 7486683
KDR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9405464 16966330 10319320
SPRY1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17496910 11447289 11997436 15031289 12402043 15173823 16893902
SHC1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 198.0 1.0 Omnipath 8808684 9083103 8551221 9126968 8621483 25416956 9252386 8524223 7535773 8662998 11302736 11827484 8995379 9541596 9175774 10207047 7717978 17673906 7744881 11505033 10523831 24189400 9927207 7650032 8810340 9045692 23178716 19531499 15812354 9129019 10356320 12485888 9461587 8114695 7514169 9566877 8939605 16371368 15341520 7529871 10891441 10749687 7524086 26645482 8491186 10592173 10049786 9171350 11707404 7537740 15688026 8663178 19380743 11782427 9544989 16436051 9434624 16713569 21725358 11964172 17314098 11792427 8195171 1465135 12213123 8647288 12955078 10477741 11707405 12577067 9199344 10080542 8112292 7760801 10570290 11997181 7798267 16520382 10961885 8950973 21706016 9448048 8662733 11370743 8051109 9733714 8621475 9254595 8294403 10748054 8621719 8940013 12441060 22057045 7505797 24737791 20697350 9886492 18174162 18273058 8235613 7963520 7523859
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
MYC HBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1904416 12695333 24725430
SHC1 HBEGF â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
HSP90AA1 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HBEGF MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
JUN HBEGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12791271 7649477 15761212 9111309
HCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
HCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17081983 16497976 15592455 16126727 17389395 1689310 20068231 16153436 16038803 10586033 1708307 7682059 15144186 12601080 18707149 8885868 8657103 17016520
HCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
HCK SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 12029088 23397142 17141806
HCK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 58.0 1.0 Omnipath 19901323 10918587 9305919 8272872 9344858 12626508 10815799 16497976 15592455 17389395 12576423 11350938 9484840 11294897 12244095 11404481 9083098 8626374 9566874 11940572 11429593 14551213 11850821 17016520 9582023
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
HGS SH3GL2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
UBE2D2 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
STAT3 HIF1A â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10347215 10973499 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 18985005 19380816 20093776 20237412 20406969 20581311 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
STAT3 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19265129 18644974 16007214 20924113 17597020 23991099
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
HIF1A TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 9242677 12393745
HIF1A PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835053 20724477 14726529 11359907 16682453 15833446 16982770 16618748
HIF1A TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18754863 15048086 17699105 16961934
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
HIF1A MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16099863 17028975
STAT3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15735682 18985005 10973499
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
SPRY1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17496910 11997436 15173823 11447289
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9069260 9113989 9235916 21779497 11739523 10545207
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
HSP90AA1 SHC1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
HSP90AA1 NRG4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
HSP90AA1 NRG1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 23220880 30854046 28274957 18039657 16843263 26545934 22046346 23843458 30314968 23948973
HSP90AA1 PLCG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
NFKB1 HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17724475 21725609 23178297 23572150
STAT1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9880553 21430289 12940076 10440232
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
IGF1R SHC1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17145802 19030972 21540285 24103846 24782617
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
WT1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8390684 7497000 16698800 15345673 11001824 9076342 12444079 10499530 11896622 7791758
PTPN1 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 11884589 15976035 8702689 16926280 8999839
SRC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17389395 15212693 18691976 7559478 7493944 7537849 20068231 23472139 8550552 17016520 8940173 9480911
IGF1R RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18988627 23331499 7642582
IGF1R PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8603569 17496910 25241761 8697095 7642582 17570479 18595745 7589433
IGF1R PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17496910 25241761 9415396 9524259
IGF1R SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12767520 15629149 7541045 17145710 8776723 7559507 14764897 17570479 16113100 24051437 17673906
MYC ITGA6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11318876 12695333
LAMC2 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10842354 8143784
LAMB1 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7721947 11733063 10842354
LAMC1 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
LAMC1 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
LAMB1 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 11733063 10842354 32196115
LAMC2 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12867433 10842354 8143784
ITGB4 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9428518 11733063 12867433 7721947 8143784
ITGB4 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9428518 11733063 12867433 7721947 8143784
JAK1 PLAU â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
JAK1 PLAU â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
JAK1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
JAK1 STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
PTPN2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 23331499 15588985 15780598 11909529
PTPN6 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 9520455 23180781 9852037 14624462 8524272 7629131
JAK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 121.0 1.0 Omnipath 18691551 20169197 19901323 12626585 12759422 15805299 10918587 9305919 15261459 21420464 8272872 10851062 12093291 17878297 12626508 12351624 12040185 16497976 15592455 20966397 8662928 18941194 17389395 23331499 11306517 8756628 12576423 11350938 12244150 18669613 7796300 11294897 24710148 11163236 11722592 11418623 8085155 12244095 21690253 14764663 9535918 21098725 9083098 8662591 22905257 14565860 27774606 8626374 19723038 29145629 26260587 9566874 24501689 25297818 9651359 11940572 11429593 11564763 12517932 14551213 8662795 19535621 23124025 18389480 15284024 11706020 11850821 17016520 9582023 17595657
JAK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 132.0 1.0 Omnipath 35317858 11839738 10918587 15261459 34950606 11306517 8756628 12244150 8156998 9535918 10748192 7657660 12817007 23257612 27774606 25297818 22306691 8631301 7510216 14963018 15284024 24243840 7592750 10851062 11823427 23331499 7532278 11418623 11722592 18988627 12637327 27387064 8662591 10022928 19088846 32953130 7796299 7504784 23124025 19787091 24058793 20169197 7543024 15322115 18941194 19534553 15978943 14978237 11294897 14764663 21429244 14565860 34228987 25386349 18989459 34521819 9020188 19535621 10982844 21576360 12759422 18508557 8232552 12093291 12040185 20006573 8662795 7690989 20087684 11438544 20035788 11972023 29145629 9355737 11152457 12517932 18389480
JAK1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9774657 15021914
JAK1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9774657 15021914 7544789
JAK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9047382 16741510 11722592 10781830
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
JUN SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7499226 16798740 23533633 14736735 18216279
JUN MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1527086 8670250 12475180
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
JUN NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18163434 19751824 16264271 20847229 7969116 8413214 10772826 10567637
JUN MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 16798740 16554298 11774399 15949416 11429784 15777790 16014933 10935492 11326313 18809380 21474819 21963718 19455716 9136992 17572495 23176293 15708369
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
UBE2I JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11877416 16713569 16055711 10788439 8733011
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
MYC JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 2123531 7775604 12695333 18838534 18414489
SHC1 KDR â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 KDR â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
KDR PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
KDR PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SRC KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19050761 18662404 18194650 10749680 12509223 18377662 10455194 16966330 12214271
PTPN6 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9405464 16453023 18377662 16337972 18840653
PTPN2 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19737086 18840653
KDR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 10749680 9405464 11950700
KDR PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15212693 16835467 12598525 10672011
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
KRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TP53 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11514734 18555006 10953306 14741382 19107228 20124454 8274455 16061648 10448271
KRAS MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12228228 23331499 8649450 7744823
LCK PTPN6 â—¼   DEPHOSPHORYLATION ✅ 4.0 1.0 Reactome 12947224 15358536 18173375 18759926
PAG1 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22566970 27045023 14610046 10790433 20813252 24764511
MAPK1 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 8506364 7499846 8618896 15967991 8226850 8626561
MAPK3 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8506364 8618896 8226850 7597029
LCK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11404481 9484840 9344858 18070987 10815799 16189514 10825200 25814554
LCK PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 23071622 8692915 16231973 23109003 14699166 19167335 12459785 12468540 11294838 10574931 7512963 16497976 16189514 14757045 8114715 10488096
LCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 9446569 17389395 18578522 10921922 10482988 10764799 18452278 20068231 18669648 12522270 9685404 10896916 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
LCK STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11839738 10918587 11438544 11152457 9355737 10748192 11294897 7657660 7690989 12817007 12637327 10982844 7592750 7543024 15322115
LCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8294442 11337495 8246987 14583609 11526404 15032589 23109003 9461588 7504174 8397196 10488096
LCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11526404 15032589 14583609 23109003 8397196 10488096
LCK STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 25885255 34021045 12060651 9813040 12456798 21716071 12970160 10825200 11641791 9573010 31697835 11046040 18250158 22177802 22442148 29228564 11254359 19923221 12879454 14522994 20667852
LCK RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11389730 1850098
MAP3K1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17563747 11278353
MAP3K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10969079 15315965 17052767 12049732 11971971
MAP3K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 25241761 15315965 12049732 24135036
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
PPP2CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 10592173 7780739 18588945 2154696 20626350
SHC1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10996427 23584453
MAPK1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9804779 25241761 18775330 10194762 8226933 10996427 9604935 8388392 12091337
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21675959 22028470 15094067 8846784 23047924 25255283 12861023 7592979 1327754 8995385
MAPK1 SLC9A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 20058876 15253667 25162926 27049728 18669648 17209041 18088087 20068231 11604491 23602949 18701649 23678047 28554535 19415658
MAPK1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10197981 8816480 9922370 8626428
MAPK1 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 20506250 15547943 18267068 15302935 12697810 11940578 12414794 17117922 23331499 21071413 23047924 20068231 16393692 9687510 17255949 15187187 19541618 19565474 17052211 15568999 19651622 14578350 11018520 15684425 11994045 11274345
MAPK1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17289590 19914168 9335504 19914161
MAPK1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11883936
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK1 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15657420
MAPK12 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK12 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15187187 19436832 15140942 20506250 21614932 16393692 24818748 11274345
MAPK12 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15187187 19436832 15140942 20506250 21614932 16393692 11274345
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
PPP2CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 18588945
MAPK3 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8798443 8960373
MAPK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9804779 20508164 23331499 24263804 18775330 10194762 12407017 8226933 17502367 34188118 9604935 18988627 31932645 8388392 12091337
MAPK3 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 20506250 15547943 15302935 12697810 12414794 17117922 20068231 16393692 19251839 17255949 15187187 19541618 19565474 18813292 17052211 15568999 19651622 14578350 11891214 11018520 15684425 11994045 11274345
MAPK3 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 29145629 7478566 23331499 8816480 7739560 17570479 9922370
MAPK3 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15657420
MAPK3 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21675959 17242355 7592979 14499342 14967450 23583303
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
NRG4 MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
NRG1 MEMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18045866 20937854 21840311 15156151
SRC MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 24728074 24034250 9837958 17570479
PTPN1 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18579758 16537444 22789536 18819921
MET SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9083103 11687594 9660480 14990987 24728074 8084588 8939605 8947042 7731718 11884620 15688026 14685170
MET PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15735664 7513258
MYC MGST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14519204 11983916 12695333
STAT3 MMP9 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MTOR MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MYC MMP9 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
SNAI1 MMP9 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
RELA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 23423566 17922642 15605368 14755547 20332461 18357389 21502320 17186550 11060311 18566231 9679762 16554298 16687076 17121934 15086314 18843978 21963718 18056465 20103608 21238464 17174275 15536164 18028425 17158602 17590163 19303700 7860222 19539355 9500201 22587999 19783786 18567920 15175338 17498959 19616091 10359016 18801463 19454280 24755270 19662350 12193473 16014933
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
STAT1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15247301 18028425 19965686 10817568 19616522
NFKB1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 17922642 15605368 14755547 20332461 18357389 17186550 11060311 18566231 9679762 16687076 17121934 18843978 21963718 18056465 20103608 17174275 15536164 19303700 17158602 7860222 19539355 9500201 19783786 18567920 15175338 17498959 10359016 18801463 19454280 19662350 12193473 16014933
MMP9 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10652271 21900405 25241761
MTOR YY1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR YY1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 29228628 10660304 22408571 12796477 16740698 18691976 26573296 15522880 27384580 26775702 24423131 26241748 23055980
MYB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18408764 19609274 8382794 1679531 1588953 1594249 9596659 11259163 8474446 2233716 16088151
UBE2I MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11779867 16713569 22910413
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC TGFB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
YY1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9797456 16314465 10528225 8266081 19279113 17287852 10713181 18490439 17434929 16878156 18542060
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
TBP MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20886042 7880838 9797456 15876353 14506152
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
MYC TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 76.0 1.0 Omnipath 16287840 15655249 12821782 16880523 21807113 19047367 14744757 16489011 12941894 10786671 14519204 19360348 10723141 12970752 15595642 18365874 15665468 22207128 14611815 10022128 15226182 11274400 10491298 11606399 17070091 19787269 19806010 20454512 19762557 21132266 21553143 18818322 10914736 17934056 19148473 11435602 12695333 12802280 21995449 11287602 12044867 21627565 23860446 17942561 19649288 23759068 10606235 12807729 15958520 17141225 20723213 16402390 16785237 18093727 21855630 24705139 18367227 14563552 16205635 19003324 9988278 17706770 17967894 18226852 18754863 10637317 18586674 14612409 19912441 15371341 11916966 12646176 11279234 18158869
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
YY1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8266081 15805285 18490439 19219071 2191300
PPP2CA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151 15048125
RPS6KA5 NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 STAT5A â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12208876 21725609 23178297 23572150
NFKB1 YY1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17438126 21725609 23178297 23572150
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
UBE2D3 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10835356
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
NR4A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23071566 17139261
PIK3R2 NRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7923364 11560935 9690470 21779497 8493579
NRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8052307 7820549 9150145 8665852 21779497
SHC1 NRG1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
SHC1 NRG4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18721752 21376233 8617750 8665853
PDGFRB PDGFRA â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
SRC PDGFRA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 7685273 9488729 10508235 9739761
PDGFRB PDGFRA â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFRB PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 21071413 2161888 2542288 7523122 1847074 16189514 11331882 10417313
TGFB1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19010789 16474430 17934056 18403754 20519943 16607286 21900405 11133108 14557817 15548370 19920116
PDGFRA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9988270 17081983 14661060 6273838 15489898 11278940 15845350 12753909 11804588 7578094
PDGFRA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 12601080 17081983 16038803 25241761 1689310 1708307 7682059 15144186 8885868 16126727 15592455 7535778 8657103 16153436
PDGFRA STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 11447289 19615955 9484840 16488589 6321473 11997436 12040186 19568798 15567848 15173823 14585353 15199124
PDGFRA PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 25241761 8702949 17452978
PDGFRA SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15592455 9121430 9446569 12767520 10921922 10482988 10764799 17673906 17496910 12522270 9685404 10896916 9927207 8702728 12237775 8610109 9741627 9710204 10816433 11075717
TP53 PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19952113 19763735 18697203
PTPN1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 18567737 7545675 7876130 14966296 7693671 19167335 8290276 12614164 12424235 9355745
PTPN2 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16971512 15588985 14966296
PDGFRB PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 10752619 8564419 1372092 7486683 7692233 7536927 16713569 11710529 8382612 8086421 11896612 8670861 8388538 9153411 1330535 17496910 1314164 16135792 7680644 19864249 10697503 15377662
PDGFRB PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17081983 7486683 2472219 16126727 15592455 7535778 16713569 23331499 1689310 11896612 15641795 16153436 16038803 23063561 1708307 7682059 15144186 12601080 1396585 8885868 8657103 8443409 23397142 15212693
PDGFRB SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15489898 18315570 16189514 9010229 2173144
PDGFRB STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17496910 8549654 11447289 19615955 9484840 16488589 6321473 11997436 12040186 19568798 15567848 15173823 14585353 15199124
PDGFRB RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11896619 1375321 23331499 8382774 1314164 7486683 1850098 10697503 16713569
PDGFRB STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 9484840 25241761
PDGFRB SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15592455 9121430 16713569 9446569 12767520 23331499 21071413 10921922 10482988 10764799 8195171 17673906 17496910 12522270 9685404 10896916 9927207 8702728 12237775 8610109 9741627 9710204 10816433 11075717
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
PIK3R3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8596638 22402981 9415396 11733063 26496610 25814554
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3R1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9113989 8596638 21827948 12147247 11733063 22020336 24165795 31031754 14665640
SHC1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
TP53 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10321740 19763735 21057544 18661553
STAT3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733515 24218138 23963458 15793565 16293640
TGFBR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15657037 9435577
PTPN6 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21780115 11337495 11526404 15032589 9065461 11160222 23109003 22880054 10488096
TGFBR2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9435577 19114990
SHC1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19531499 8662998 7537361 19380743 8621719 16135792 9541596 16219545 16713569 23397142 19889638
PIK3R1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 19531499 25241761
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
PTPN6 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21780115 15032589 11526404 23109003 9065461 22880054 10488096
TGFBR2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9435577
SRC PIP5K1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14691141 20850356 15738269 15623515 16616931
RELA PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11689575 20352621 18226221 19165610 22797919 20018891 10467400 9914486 17407600
PLCG1 SRC â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
PLCG1 SRC â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
SHC1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SRC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 8388373 16497976 16126727 16713569 17389395 1689310 20068231 17570479 16153436 16038803 1708307 7682059 7510703 18594017 12601080 8885868 8657103 17016520
RHOA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12071848
PLCG1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15953601 12084069 7629168 9020117 16713569 10913276 17474147 10940929
SRC PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 25003662 10978272 21292165 23796501 24676687 22771321 24395787 17635907 26378614 16286244 27013170 23222956 25726524 24997451 31992581 12921784 1325671 17303700 23251465 20558158 21554241 23926298 25931585 22299660 18208556 21791414 23436320 32130916 17394530
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11591705 12842894 17188031
PPP2CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17245430 14712210 1848668 16713569 12556559
TGFBR1 PPP2R2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9774674
PTK6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18083107 17389395 21741923 19534553 7701321 19304789 16568091 15592455 12763138 15951569 20929863 18234692
PTPN1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15821101 23331499 11970898
PTPN1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 10698938 25585026 17092689 17974954 16537444 18332219 9600099 15866871 8647855 9261115 11346638 12857726 12468645 11007774 1646596 16115959
PTPN1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10993888 12237455
PTPN12 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20697350 8939605 12052829 24189400 24412244 7929214 20075861 19380743 11342545 8626541 11432829
PTPN12 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19595712 18482983
PTPN2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12138178 12270932 15699106 19833085
PTPN2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 15588985 12138178 15780598 19737086 16189514 35091679 18948751 16431927 12359225
PTPN2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15588985 9488479
PTPN2 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 15588985 15780598 11773439 11909529
PTPN2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15696169 18948751 27611995 22080863
PTPN2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 14600148 23331499 12923054 12171910 12138178 15780598 19737086 16431927 19171783
PTPN6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 12176909 12773515 12917349 15240681 15713798 22513334 22952938 25355530 26667266 27474009 8976179 8986721 9765283
SRC PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8692915 17675340 14551136 25535246 14699166 12468540 10574931 16649996 8647855 7512963 9261115 34010642 14757045 12468645 8114715 15212693 10488096 21900501
SRC RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11389730 1717825 16713569
SPRY1 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 11997436 15173823 11447289
RPS6KA5 RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
RPS6KA5 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17145710 27768872 19197368 22187158 20204068 22216091 19706715 30240634 25241761 11931769 19910110 21791059 23536830 23485395 22312446 19789307 24705157 27009097 17255956 12628924
RPS6KA5 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 20058876 15465816 10521505 12576423 18691976 11350938 9872331 14551213 20068231 10446219 12763138 19413330 11335711 20626350 18491316 18669648 9343414
TP53 S100A4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19740107 15116098 23752197 20591429 20070253 11527429 12942774 31837246 11278647
S100A4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19740107 15116098 23752197 20591429 20070253 11527429 12942774 31837246 11278647
SOS1 SH3KBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11071869 22262777 9697839 21822214
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
TGFBR1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 12767520 22710166 23331499 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
TGFB1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 22710166 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
TGFBR2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12767520 22710166 19010789 16474430 19920116 22943793 17934056 20519943 12809600 21900405 11133108 14557817 15548370 17673906
SHC1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 9544989 8631299 8621483 8950973 10891441 10783152 9278309 17673906 9344843 8294403 8021500 10025673 7520523 12955078 12577067 9199344 19531499 7760801 10570290 19380743 8235613 10675333 8114695
TGFBR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19651622 9748228 9335504 10085121 9136927 15212693
SRC SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 9856337
SPRY1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 11447289 11997436 11585837 15173823
TGFB1 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
SRC STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 16472776 17192274 19930715 22131018 22677902 23589069 23691193 24030100 24403062 25687758 27036022 27452906 29556339
SRC STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 11839738 10918587 9344858 7543024 15322115 10358079 14978237 11294897 7690989 16189514 12637327 11438544 10748192 7657660 12817007 9355737 11152457 10982844 7592750
SRC STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11413148 17081983 10358079 22090359 7925280 16189514 15702476 11641791 15212693 8617237
SRC STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 19901323 10918587 9305919 8272872 29036202 9344858 12626508 10815799 16497976 15592455 16713569 17389395 12576423 11350938 9484840 11294897 28978186 18070987 12244095 27472461 21690253 23928694 22303479 8657134 11404481 9083098 14963038 8626374 17016520 9566874 10982829 15212693 11940572 11429593 14551213 15037656 15313931 11850821 9154828 9582023
SRC TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12808100 20211239 24413564 26908447 18829466
STAT3 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15240880 19233843 16226915 19913854 15913829
STAT1 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT1 STAT3 â—¼   DOWN_REGULATES ✅ - 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
STAT1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19122651 17558387 22693070
STAT3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 25609649 8662591 12070153 31462771 25241761 11722592 8710878 9794795 23268184 15284024 16189514 9535918 11594781
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
TP53 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15656906 12807729 15067344 15734740 11064449 15262117 16234237 10778946 15371422 22496369 18754863 19649288 19787269
WT1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12807729 22654424 20842112 10601322 18754863
TGFB1 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TGFB1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22326956 10187774 7852346 22703233 12809600 7706250 11323414 8047140 8235612 26194464
TGFB1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 122.0 1.0 Omnipath 1310899 22874531 8047140 11279127 22710166 7878020 16424049 17673906 24132110 18922473 22943793 12729750 16446785 20519943 7706250 15761153 7594497 15548370 15761148 15265520 19010789 26194464 7852346 12717440 17768418 19050695 11133108 14557817 11278410 19920116 22949611 22703233 23331499 23070005 20060931 17070508 21614932 1333888 10716993 16572188 20860622 11323414 21900405 12724770 8106553 23034983 26192618 2871107 12809600 11382746 21372296 20538542 16200688 11792802 26201938 24403530 15099563 11013220 17979848 21054789 23784029 15003992 20644162 8515656 7935686 11157754 20856203 18382895 15282297 18855897 9865696 21441952 10678166 16127449 21041659 10026191 22315516 12767520 17404308 19732719 20616810 21071413 17934056 12738796 18423981 21098712 19747910 9311995 15034927 11274345 12154066 18758450 24336330 21278795 26966341 9261125 16474430 15653932 18490733 8242742 19038247 19109155
TGFBR2 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 7774578 9463378 19556242 8047140 23868260 18243111 7890683 10026191 23331499 8576253 21071413 7878020 21791611 10716993 18988627 11278251 19758997 25825445 22802914 16446785 11483955 8947046 11323414 11124802 15221015 11102446 11387212 12809600 7566156 26194464
YY1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10787423 10634504 8816507 10505791 18391986
UBE2D1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
WT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16713569 10744705 8389468
TP53 KDR â—¼   KO_UP_REGULATES ✅ + 1.12 1.12 PKG 28854368
ATM LMNA â—¼   KO_DOWN_REGULATES ✅ - -1.21 1.2 PKG 28854368
ATM CAV1 â—¼   KO_DOWN_REGULATES ✅ - -1.92 1.91 PKG 28854368
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
ATM ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -4.02 4.01 PKG 28854368