Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ATM EYA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19234442 19351884
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
BCL2L1 BAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
BCL2L1 BAK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
ETV4 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18510939 15466854
FOXO1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15817464 15632117
MITF BCL2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23447565
FOXO1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15059979 10871843
HIF1A BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17558861 19211554
PAX3 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10871843
FUS BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18471544
CDKN2A BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19049976
BCL6 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11920165 11341761
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 ZBTB17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17828269
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
SKP2 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16376880 5218183
CDKN1A DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19541625 0812254106
NOTCH1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11306509 14670925
PML CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10356361 16007146
NCOR2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24821728 24821727
NUPR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22858377 18690848
EGR2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16708405 18779345
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
CCNA1 CDKN1A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
DDB2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678110
PPARG CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15041706
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
CDKN1A POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678112
CDKN1B CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TCF3 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19451188 20191379
MAX CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11313917 18393360
PPARG CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11034103 15763423
CCNA1 CDKN1B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FLT3 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28522571
MYC CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24704206 26701207
KMT2A CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16997566
PBX1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21746878 15611658
NSD2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19340300
ESR1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 10851069
PAX3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17986608 19047133
TWIST1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22290439 20818389
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
NFE2L2 DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22691366 14978030
DDIT3 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10912181 10510472
DDIT3 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18649942 15829559
DDIT3 ITGAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19359519
DDX5 TRAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC DDX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
E2F1 ZEB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17655524
E2F1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
E2F1 ETV4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18687701
E2F1 CDKN2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22504641 12077144
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9368006
E2F1 RPL32 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15897325 18319725
E2F1 MYCN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12438307 18319725
E2F1 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15867358 18319725
E2F1 CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12077144
RUNX1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16917507 5218981
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 CCNT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 7265510 19387490
EP300 H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
SIX1 EYA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12783782 20110314
FOXO1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20082134 18444242
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20338229 15632117
CREBBP FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10973497
FOXO1 NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18391971
FOXO1 ABCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18390843
FOXO1 CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18444242
TP63 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9405685 9032395
CEBPB GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16418324 11012671
MEN1 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
MYC TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEBPA MYC â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 11340171 20581311
NOTCH1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10644343 16847353
RUNX1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29958106
ZMIZ1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26522984
ERG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25277175 20820186
CEBPE MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12947005
EWSR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8164678 11423975
MYC CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21925595 23722468
MYC RPL32 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916 11085504
MYC EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18365874 11509655
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
MYC NFYA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11282029
H3C14 NOP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 PAXIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
PAXIP1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PIAS4 GADD45G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 ZHX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
PML JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671405 10620019
TP53 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678112
SP1 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17099721
SMARCA2 RSL1D1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3C2 SNAI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7903691 20389281
SMAD2 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19389392 18618014
HIF1A SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23979441 23496980
SNAI1 ZEB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21317430 12161443
SNAI1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17909010 19604315
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
TRIM24 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0813177106 19556538
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
TP53 CDKN2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SAE1 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 15327968 5217177
PAX8 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8521821
MAX TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7969121 10348347
TP53 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
TP53 TWIST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504427 20689556
COP1 TP53 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 15103385 5217012
MYCN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20145147
TP53 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16917513
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16557594
TP53 ABCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10783169
TP53 RGCC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP63 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 2196176 2854202
TP63 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20442293 20950370
TWIST1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22056872 8313152
TWIST1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TWIST1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22056872 22457607
TWIST1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22891766 28283022
SIX1 FGF10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12874121
FLI1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25108845 23108091
ESR1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20404154 17932106
RUNX1 HHEX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28213513
HHEX TLE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15187083
TLE1 CDKN2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
KMT2A CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16997566
CEBPB GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11012671
SMAD1 GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22219353
NFKB1 GADD45G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23681230
JUP BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ETV6 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11439334 10913166
ETV6 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17606295 19829305
TCF3 ID2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19321746 0900912106
ID2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
POU5F1 ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17068183
MYCN ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12670915
HIF1A ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15252039 11955624
VEGFA PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15026417 9182576
SP1 VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19147754
ATXN1 TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGFBR2 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
ATF1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10567368 9694866
ETV4 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14976186
RARA PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10361124
PLAU PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721771 16189514
TGFB1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
SMAD2 RXRA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21836474 21926264
SMAD2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14500551 12853969
SMAD2 GADD45B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14630914 12933797
ESR1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10935492 12878732
ETV7 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16722933 11556732
MMP1 MMP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 7780967 1371271
CREBBP MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15894584
NFKBIZ IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15241416 26226212
NFE2L2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21127061 27211851
TFE3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20713358 21389977
ZEB1 MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21241837 19116136
HIF1A NOTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NOTCH1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
ZMIZ1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26522984
NOTCH1 ZMIZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26522984
NOTCH1 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
NOTCH1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330899 22363130
PTK2 ITGB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16874740 10592173
MYCN HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18003922 0705524104
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
TRIM24 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1101544108 21531907
NFKB1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
HDAC1 MYCN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18003922 0705524104
HDAC1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16431920
HDAC1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20037778 19435809
BCL11B HDAC1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219549 17245431
PPARG HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21151932 16431920
HTT SIN3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
MAX CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11511535 10508165
NCOA3 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16877447 16860316
EGR2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 2115122 1427072
KDM2B JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17704768
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
JUN ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21384344 16786139
MEF2C JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9384584
JUN PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
RARA NFE2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709483104 18048326
NFE2L2 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22911891 16172382
NFE2L2 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23637463 22547061
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
MAF NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18694732
PPARG NCOR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17011499 8970730
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
PPARG FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12921977 17320065
PPARG CD14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15741503 17237441
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
PPARG CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21690289 12813462
PPARG PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18309368
SPI1 CD14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18227805 12393465
CEBPA CD14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
SPI1 CEBPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8695841 22474248
SPI1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22105598 12032776
SPI1 CSF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
SPI1 ELANE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9689920
SPI1 CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8264604
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
NFKB1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
NCOR2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12589049 10612426
EWSR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8552387 12459554
SS18L1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14716005 15488321
CREBBP H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
CREBBP H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
HTT CSF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEBPB CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7513199 21455770
GZMB ELANE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6796478 9404514
MITF GZMB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1999537 9558376
CEBPA IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10453008
RUNX1 IL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9036972
HIF1A PROM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23840432 19738050
HIF1A KDM2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
HIF1A FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16601206 15192019
HIF1A BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 17043658
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
HIF1A MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18400834 18588890
HIF1A CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18461556 18381421
ATF1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7499271
ETV5 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15138262 17390339
ABCB1 CAV1 â—¼   COLOCALIZATION 2.0 0.8 intact 15498565 5217256
SP1 EPAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17024177 5219187
SP1 PAX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20435036 18314536
SP1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10373535 12049196
ESR1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19797124 20819530
ERBB2 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19861462
RUNX1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19686049
NFKB1 NCOR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17876798
NFKB1 NFKBIZ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20220144
NFKB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21790895
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
LMO2 LDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17964543 24874989
LMO2 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20676125 21536859
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
KMT2A BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25056311 19208841
LYL1 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8628307
ESR1 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22927007 24374826
CEBPB MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21917825 19723873
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
TFE3 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14962802 11818452
CEBPA RUNX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17431401 5219852
KMT2A RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23817177 22012064
RUNX1 CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
RUNX1 CEBPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17431401
RUNX1 ELANE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
CEBPB NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21150337 9019155
CEBPA ELANE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
CEBPA CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
SMAD1 KMT2D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
GLI3 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19860666 17419683
H3C2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KLF3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZHX1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H3-5 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
C7orf50 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H3C14 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT ECH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
ESR1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11060032 21610700
ATF1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10683356 7843287
ETV1 MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14550555 11593430
KMT2A MLLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7900984 18952892
KMT2A MEIS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16199523
ATF1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10698518
ESR1 TMPRSS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19013008 18414489
FLI1 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21536859
LYL1 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21536859
KLF3 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LDB1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZNF609 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZHX1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
RXRB RARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RARA CEBPE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14576045 12032776
NCOA3 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18022353
NCOA2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18022353
EPAS1 KDM2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
PAX5 CSF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21549805 16482219
PAX5 CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15676205
ATF1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12044952
ATF1 ARNT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12527906
RXRA ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14527955 24007921
GLI3 WNT8B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21452227 22235033
CEBPE ELANE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10233885 17347301
EWSR1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16206264 10975680
FLI1 EWSR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16206264 10975680
PAX7 PAX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18513381 17954266
EWSR1 ATF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9569031 12527906
H3C14 H3-3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NCOA3 RXRA â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CCNT1 MYC â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
EP300 FOXO1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
DDB1 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 34026424 25189618 24249678 26679995
SMAD1 DDX5 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18548003
BIRC2 E2F1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 28542143 30359437 21653699
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
EP300 PAX5 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31941781 21357426
PPARG SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18509005 24735796 20360975 22282354 18310298
CCNA1 SKP2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16774918 19270695 17308064 10652300
CREBBP RXRA â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CREBBP FOXO1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
ERG EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 28536097
EPAS1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 15261140 22807441 25689462
MYC RUNX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
MYC NCOR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC TFAM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
PML PPARG â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32929351 20211142
ETV6 SIN3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12527908 11439334
MYCN HDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18003922 31856871
JUN HDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17056544 25609649
PPARG RARA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 32929351
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
SP1 EPAS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22402494 17024177
PCGF1 BMI1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 26687479
BMI1 FUS â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
ECH1 TRAF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25416956 25996949
AFF1 CCNT1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
ESR1 PRR12 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26487511 31527615
NCOA3 NCOA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18267973 11971985
NCOR2 RXRA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9415406 9878542 12665583 15604093 10082574
EPAS1 ARNT2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 20211142
SIX1 TLE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16189514 12441302
CDK9 DDX5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17643375 26209609
NCOA3 E2F1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16938873 15169882 16648476
CCNA2 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NUPR1 FUS â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19650074 16478804 32780723
PIAS4 SMAD1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 15231748 12904571
SNAI1 EGR2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ETV4 STK11 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150337 16912160
MAX SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29028833 33961781 25609649
NFYA JUN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11903046 21565167
CCNA2 CCNA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ETV1 DET1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NSD2 ESR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24101509 31527615
TLX1 MEIS1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19559479 11342305
ETV5 DET1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
DEFA1 DEFA3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 NCOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 0.83 0.83 Signor 11477071
DOT1L MLLT1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
HDAC1 SMAD2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CDK9 SKP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11689688 12861003
ETV4 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9194565 14976201 35140242
SNAI1 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28296173 25314079 32494626
FOXO1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
CEBPA HDAC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15713621 22355045 23898169
CEBPB SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16651265 12847250 12665574
ESR1 RXRA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9717844 23403292 9121466
DDX5 ESR1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
HOXA9 KMT2A â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
PPARG SP1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CREBBP TCF3 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CCNA1 SKP2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
BAK1 TP53 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
JUN PML â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
CDK9 CCNT2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
RUNX1 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 14752096 16917507
PAX8 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10924503 35140242
MEF2C EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21556048 9001254
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
PML RXRA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16540467 10610177
TLE1 TLX3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 35140242 19250647 20211142
SMAD2 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10199400 11226163 31130994 14699069
SMAD2 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20207742 11555647
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
SPI1 JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12091339 9681824
CEBPA SKP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32622945 34002296 21988832
MYCN SP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18003922 21123453 20697349
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
RARA NCOA2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 9430642 12503607 12612084 9192892 20543827
TLX1 TLE1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 35140242 19250647
CEBPB RUNX1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CEBPB EP300 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
HDAC1 RUNX1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
EP300 FOXO1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15890677 24419059 25609649 18786403 11896584
EP300 NCOA2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10490106 9920895 15731352 20448036
ESR1 MEN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16651450 31527615
PIAS4 SMAD2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12815042 12904571
HHEX PML â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10597310 16189514
PPARG CAV1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12813462 21690289
SPI1 CEBPA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16983342 12091339
RUNX1 NCOR2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17560331 16042694
ESR1 CCNT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15940264 31527615
NCOR2 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9702189 14715875 20392877 12738788 9171229 23403292
ATF1 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31527615 21217774
ESR1 RARA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9717844 25303530 25604459
CDKN1A GADD45A â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CEBPE DDIT3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15588942 23661758 20211142
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
ETV7 ETV6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 35140242 33961781 26186194
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
NCOA3 RXRA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9267036 16713569 9346901 15863722 11027271 11851396
RXRA FUS â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 32814053 9440806 16713569
ARID1A ARID1B â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK9 MLLT3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MYC SKP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AFF1 MLLT3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ARID1B SS18 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CREBBP HTT â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF1 MLLT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF1 CDK9 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
DPF2 SS18L1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HDAC1 SNAI1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 TNFRSF1A â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PTGS2 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A VEGFA â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PML RARA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RARA RXRB â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK9 MYC â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 TRIM24 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
DPF2 SMARCD2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
E2F1 SKP2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PTK2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDK9 MLLT1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
MYC CDK9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12944920 19818711 26687678 11673469 17700062 30415952
CCNA1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16774918 10022926
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
FUS EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18509338 30110629 33742100
SKP2 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22770219 18243116 26593157
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
NCOR2 PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11585900 11430826
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
SMAD2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11114293 10878024 22227581
JUN RUNX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11641401 11274169
RXRB PPARG â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20211142 22205725 15604093 25609649 30699358
PYGO2 BCL9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11955446 24981860 17113272 14612447 21399610 31073027
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
CEBPB CEBPA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20102225 1840554 15751966
RXRB RARA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 29892012 16189514 25303530 32296183 16713569 21988832 20211142 15604093 26871637
TFE3 MITF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11818452 33961781 28514442 11930005
ZHX1 NFYA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10441475 16713569 10571058
CDKN2A MYC â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
MYC ZBTB17 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CCND2 CDKN1B â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BIRC2 TRAF1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
SMARCD2 SS18 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ARID1B DPF2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
DPF2 SMARCA2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
DPF2 SS18 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CREBBP SMAD2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
HDAC1 BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15454082 9627120 9753732 16147992 10611298
AFF1 CDK9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32707033 32479599 20153263 33961781 21729782 21030982 23602568 26186194 27684187 23455922 24367103
DET1 DDB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33911083 33961781 31155351 17452440 16964240 14739464 16949367
CEBPA DDIT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 27555288 23661758 20102225
JUN DDIT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10523647 23661758
HDAC1 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20663877 20022962 15298701 19995069 17369852
FOXO1 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22266855 11435445 11353774
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
MYC SKP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23277542 12769844 12963825 26038816 17157259 24259667
RARA PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11050004 1311253 16189514 16713569 16540467 10882117 17560333 18073335 10610177 12935927 20159610
CCNT1 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28555140 12727882
PML JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15626733 9671405 16916642 10620019
SNAI1 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21685935 26794444 25314079 20562920 23011797 14673164 34026424
TGFBR2 TGFB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8044119 21054789
SMAD2 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11371641 20195357 10220381 25609649
HDAC1 NSD2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18172012 16197452 18156491 22972034
HDAC1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11739383 16481466 11013263
HDAC1 SPI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14647463 16331260 11593411
NCOR2 SIN3A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10944117 10640275 11013263
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
JUN ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17317669 11477071 16713569 23747343
SPI1 FUS â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 9478924
HIF1A SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 17024177 17418410 15780936
CAV1 FLOT2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 10212252 16189514
RARA SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18270252 10361124 19401466 16713569
SP1 RXRA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18270252 10361124 10393239 16713569
AFF1 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20153263 21030982 27684187 19956800 24367103
FLOT1 FLOT2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17113085 30021884 34079125 22939629 24167781 24809731
NCOA3 RARA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25303530 16713569 17475621 9346901 12665583 19144644 15604093 9192892 20413580 16456540
PCGF1 KDM2B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16943429 26687479 25533466 27505670 23395003 29985131 32628469 27705803 22325352 33961781 29502955 24981860
RXRA TRIM24 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
SMARCA2 SS18 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
TCF3 TWIST1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CDKN1A SKP2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CCNA2 E2F1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EP300 NCOA3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
NCOR2 RARA â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HDAC1 NFKB1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
NCOA3 RARA â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DOT1L MLLT3 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ARID1A SS18 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CCNA1 CDKN1B â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
ATM ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20730097
TP53 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 15077116
CEBPB BCL2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19489038 18512730 12665576
TLE1 BCL2L1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ZHX1 BCL2L1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CEBPB BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19043455
SIN3A BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16147992 9765306 9753732
NCOR2 BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23911289 15454082 26728228 9380707 9824158 9765306 11865059 15531890 14690607 10898795 16147992 10611298
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
BCL6 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21106671 12594267 15507530
EP300 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17828269 12402037
CDKN1A TLE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A NGFR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
EWSR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12560328 18757425 20153576
RUNX1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10617663 23487742 23150456
HIF1A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19342889 20138114 19940121
ESR1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17163418 17681750
KMT2A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16169901 19318494 19031738
JUN CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10700231 20566634 19959471
ERG CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
EGR2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
FLI1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
NFYA CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
ETV1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
MITF CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19067971 15623583 1999537
DDB1 DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22118460 28035050 12050362 24249678 26410533 22822215 28416769 29262658 16473935 18593899 30923324 16678110 16964240 20368362 12812979 19295130 16751180 19109893 17360488 16260596 27203177 17392787 10777491 12151405 32985517 14751237 22039351 17041588 12732143 11564863 9418871 19966799 33961781 26186194 34251884 16949367
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
CEBPB DDIT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12706815 20562859 33961781 20102225 1547942 8662954
JUN DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19299913 22622069 12069855
MAX DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15021909
DDIT3 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18940792
DDX5 FUS â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
DDX5 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 33742100 12527917
DDX5 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 25604459 12738788 20308691 11250900 21182205 10409727
EP300 DDX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12527917 20663877
CEBPA E2F1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12869508 11340171 12702500
SKP2 E2F1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12097298 17471231 23868976 27720894 16170383 10559858
E2F1 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8458319 7969176 12501191 35140242 9724724
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
E2F1 MEIS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
E2F1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20639906 16835303
E2F1 NCOA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16916939 23660594
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15711575 12110166 18319725
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
EP300 NCOA3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16923966 10655477 9267036 23065768 16227615 20368990 11823864 10490106 25728767 33589584 10866661 15145939
EP300 CEBPB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28428115 9343424 14630807 12471036
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
EP300 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 17468099 10944516 14701856 11287611 19596656 32603375 11877444 12040021 10075656 30595551 22787115 12479814
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
EP300 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11796223 11062529 9001254
FOXO1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12391153 15613482
FOXO1 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20088826 17599040 15632117
ZHX1 GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TLE1 GADD45A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45A TP53 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GADD45A JMJD1C â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAX GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15021909
KMT2A MEN1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
MEN1 SMAD2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22275377 11274402 15150273
NFKB1 MEN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11526476 16651450 16713569
MYC MEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
CCNT1 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12944920 19818711 11673469 17700062 29467282 30415952
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
MYC HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 18271930 34147029 26496610 30415952 18003922 22286234 24951594
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
CEBPB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21098707 20581311 16585579
MYC MEIS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC NOTCH4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20123981 17382917 22550094
MYC CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10229837 11145693
MYC CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10918582 18444242 11258956
MYC TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
NOTCH1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2191300 18490439 19219071
CEBPA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
MYC CEBPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
SP1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9819401 21360626 24728382 16713569
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
PML SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15356634
ESR1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21689749 22226967 18414489
SP1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22412893 23995788
CEBPB TNFRSF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19523687
PAX5 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8521821 22105368 21319196
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
TP53 HNRNPUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17530187 15456866
TP53 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22804246 23666675 20406462
HNRNPUL1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15907477
TP53 CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16169070 16713569
TP63 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27132513 8258457 23071313
PPARG CCL2 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 10432118 17681149 23390297
HIF1A CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27271610 17474992
HHEX FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20176809 22844093 22874537
ETV4 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19129951
SMAD2 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11486006 15188178 18952601
EWSR1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10749119 14534527 10508522
NFKB1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11689575 17407600 20352621
SMAD2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27974707 11456453 16284942
HDAC1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10199400
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
HIF1A MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20631454 19285046 19950212
CXCL8 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18660381 17375198 11023497
NOTCH1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14597575 23331499 14500836
NOTCH1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722525 23331499 16256737
ESR1 ITGB7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
RUNX1 HDAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18316480 10617663 22777353
HIF1A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17273746 11641274 16511565 21148070 24015760
SIN3A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15695521 28514442 9520398 10640275 14647463 12398767 9150133 10444591 14593184 21258344 12943729 12374985 17956988 11102443 9885572 17962807 26496610 12453419 11171972 16331260 20585571 10220385 25314079 12091390 11931768 17643391 11602581 17827154 12724404 11784859 23752268 18059533 9790534 9804427 26949739 24981860 33961781 19182791 11118440 15451426 12920132 26344197
ESR1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17312152 31527615 24051437 33731348 14722073 21182205 15557281 18451880 14506733 15140878
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
JUN GZMB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath
JUN NOTCH4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23917222 21679465 17220278
NFE2L2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17313370 18241676 18199529
NCOA2 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 23178929 15026545 10944516 19596656 11877444 17513608
NCOA3 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 23178929 10944516 15604093 19596656 35140242 11027271 11877444 15888456
PPARG RXRA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22363753 16189514 12763030 10944516 31547433 30404011 20211142 35140242 25609649 17312272 23703729 7838715 19047629 12966085 22205725 14587029 10882139 30595551 30699358 9065481 21833030 9568716 34081964 21478865 9121466 23275339 17579352 19147680 26260846 16713569 12591919 10854698 30651555 32929351 23711995 11877444 15888456 18217139 19043829 17980149
NCOR2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22395773 21846906
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
CEBPE SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12032776 12202480
PAX5 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10688639 11179673 21549805
SPI1 MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17030072 14688368 9178763
RARA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23321499 16417649 21110951
NCOA2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14966289 11747826 16613851
CREBBP NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12789342 16835236
SP1 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7811231 8524292 11418664
CEBPB IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12574125 10453008
SP1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8454603 23226269
SKP2 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9858587 26496610 27720894 33422522 16209941 33961781 24632684 15355997 26186194 7553852 31181401 20160477 10559858 33989513 18604603
CCNA2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9858587 15355997 33989513
SKP2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9858587 15355997 33989513
ESR1 BCL9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
MITF HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15983061 22012259
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
HIF1A MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17335808 18588890 20102637
HIF1A CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21029732 16399861 19304911
EPAS1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15192019 18625704 19616846
FLT1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24043698 12023386 29435030
ESR1 CD86 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
CAV1 FLOT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25204797 10212252 34079125 22936677
CAV1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11563984 23634843 22230296 19595769
ETV4 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15138262 19483189 17390339
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
SP1 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22399227 20018729
SP1 NGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11839795 19114034 21123453
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
NFKB1 BIRC2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 21725609 23178297 23572150
NFKB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18234965 12527911 19763573
NFKB1 MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11376631 19275880
ERG MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8957070 9334186
BIRC2 TRAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 11907583 16713569 21988832 20447407 9384571 8943045 25996949 33961781 23524849 16891304 30561431 8548810 21903422
BIRC3 TRAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11907583 25241761 16713569 30948266 9384571 25996949 33961781 23524849
RUNX1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22451420 11283671 17894555
TLE1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17145710 9751710
CEBPB ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 16651265 7651415 19652226 9817600
CEBPA DEFA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10706719
NCOA3 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26153859 20392877 15383283 14766010 25728767 21182203 15145444 18484708 11376110 14966289 9346901 20181721 26166704 16331275 28844863 11389589 11050174 12630920 19491275 17158759 23403292 12714702 17646391 9192892 11353774 16923966 18645020 16713569 30418174 10490106 9765300 12554772 26487511
NCOR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17591692 23015261 15802375
ESR1 PTCRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10938099 12149645 11459795
RXRA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
ESR1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
ERG TMPRSS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23913826 20563261 24418414
RARA NCOR2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19377461 9415406 25303530 16713569 17475621 9380707 16219912 15604093 9256429 7566127 11929748 10082574 20543827
RARA CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11090075
RARA MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15246741 10415749 1682056
ETV4 NCOA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22505454 18644862 18593949
NCOA2 RXRA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15657427 9430642 21478865 24561505 11514567 11851396 11981034 17947383 10748178
EPAS1 POU5F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20139178 19755485 16510872
RXRA PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19538480
ETV4 SYN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19842069 7592648
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MRPL11 MRPS12 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CCNA2 SKP2 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ARNT2 HIF1A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
FLOT1 FLOT2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
BCL6 NCOR2 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
MAX MYCN â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
TLE1 HDAC1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 19101520 22439931
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
HOXA9 PBX1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
BAX BCL2L1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ARID1A SMARCD2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
NOP2 RSL1D1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
KDM6A KMT2D â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
KDM6A PAXIP1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
MEIS1 PBX1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CCNA2 CDKN1A â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CCNA1 CDKN1A â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
BAK1 BCL2A1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CDKN1B SKP2 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
SP1 NFYA â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 30392062 10393239 15647279 10446910
ESR1 NCOA3 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
DDB1 DET1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
EP300 TCF3 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
EYA1 SIX1 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
ARNT2 HIF1A â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 8927054 33961781 24722188
MEF2C PTK2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ARID1B SMARCA2 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
NCOR2 PPARG â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 23178929 17704298 15681609 15604093 19596656 35140242 11877444 30595551 17312272 23703729 16219912 19147680 20364085
RXRA RARA â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5212283 10698945
ARID1A SMARCA2 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
NCOA2 PPARG â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
ID2 TCF3 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
NCOR2 RXRA â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
SMARCA2 SMARCD2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
LDB1 LMO2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CDKN1B CCNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 34591612
E2F1 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10850422 10409740 8657141 10547281 8657142
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
NCOA2 RARA â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CDK9 CCNT2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 9499409 16331689 18566585 17643375 10465067 33961781 24981860 21729782 26186194 23602568 11282025 27684187 23455922 11713533 26344197
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
HDAC1 NFKB1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 12972430 17962807 24448807 11931769 14678988 16319923 17827154
NCOA2 ESR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14766010 12612084 11250900 12837248 17697320 11376110 9430642 11265755 20348541 19460354 18499756 12630920 12714702 9192892 15657427 11014206 16645043 11937504 12554772 26487511 9774463
RARA RXRA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 9415406 25241761 21988832 16540467 15604093 1310351 10698945 14521715 12052862 9582446 19345331 31700049 7760852 15528208 21478865 9121466 10882070 16769902 15171703 22539306 25303530 7705655 16713569 1314167 16224062
BIRC3 TRAF1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CREBBP PPARG â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
NCOR2 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CREBBP NCOA3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
BCL2L1 TP53 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
FLT1 VEGFA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CREBBP KMT2A â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
KDM2B PCGF1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ARID1A DPF2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
BAK1 BCL2L1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PPARG RXRA â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RARA RXRA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
NCOA2 RXRA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CCNA2 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
MYCN MAX â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 2006410 23792191 26062444 24859015 10229200 1935896 18003922 18488021 27728805 10597290 29028833 25175806 17289033 20946988
ESR1 NCOA2 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
PBX1 MEIS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 20237320 20211142 10082572 20541704 10523646 10373562
CCNT2 CDK9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SAE1 UBA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MAX MYC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATM PAXIP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
ATM STK11 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11331603 11571274 11877377 12234250 12607003 15140942 15459660 15964794 16163361 17303408 18001824 18006705 20160076 23030059 23847781 9488723
PAXIP1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15456759 19414588 17690115
ATM TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24366874 20023394 18769144
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27245613 24681585 21095578 18971907 21095582 27027353 23573973 27068951 25956861 23707302 26942179
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM COP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 25957415 16931761 20843328
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 11853558 25329316 12234250 12805220 18971907 20864035 29284117 21191146 17570479 20160076 25488815 25244018
ATM SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22588298 23277204
DDIT3 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17166886 23339468 16597647 14612528
TP53 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22983126 18519674 21233848 15033822 15489892 15105295 10741712
BCL2L1 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 22705850 9463381 22516262 31467278 32814053 9020082 23680104 34098062 18178565 15901672 16189514 17446862 20836993 23055042 19060904 17289999 32296183 10085290 14596824 15292519 29997244 31515488 11175750 9027312
BAK1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15901672 11571294 16189514 16439990
NFKB1 BAX â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 12676992 15613549 21725609 23178297 23572150 7834749
HIF1A BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18366759 17558861 15706354 24349374
E2F1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9748148 11095619 12370749 14514686 15255934
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
SP1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278953 10510469 11748232
MYC BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8845569 11103792 12695333
BCL2L1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 59.0 1.0 Omnipath 22705850 18981409 21458670 28202514 11283018 17525735 29749471 21567405 9388232 18547146 19074440 16151013 21199865 18178565 26496610 16189514 15486085 26186194 17289999 9111042 12419244 25241761 14963330 12853473 9742125 9153240 19427863 21852238 14766748 21671007 15131699 9670005 8596636 24814347 9824152 9027312
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
NFKB1 BCL2A1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 10049356 21725609 23178297 23572150
NFKB1 BCL2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19343319 12665576 17000776 11880364 15592513 10733571
NFKB1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10925251 17673602 12176906 11992002 14978135 15231833 14739605 10585435 20066113 16904634 9439816 18222423 10733571 15756023 15986355 12226754 15856023 16453001 11756417 18223231
TP53 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869582 9582400 9989972 11713584 18172861 23519249 12705879 9000137 11713302
MYC BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14517295 18802399 16316993 17331788
NFKB1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10428780 19211554 10435632 10428030 11756417
TP53 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BCL2L1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
SPI1 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19564417 15892171 31000603
BCL6 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23954399 12097386 21801248 21106671 10973278
BCL6 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19337254 18648506 15509806 22723377 17392284
NCOR2 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17145710 9380707 15531890 10611298 15454082 23911289 16147992 9824158 10898795 14690607 11865059 9765306
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK9 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
CDK9 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22158970 33593309 29170386
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
CEBPA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15466360 9442037 12502863 8846917
ID2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17639499 16557594 21900881 16428453 11706002
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
SMAD2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9618481 12200968 17516505 14762439 10506225 24052079 14583455
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
E2F1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9748148 9191053 16923815 17008321 10030670 10702805 15048076 17167174
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
FOXO1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17609436 23574718 23918930 24769335
TP63 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15790310 10383130 21480565 12640112 20123734 17404570 16007146 16410722 15965232 12374749 17965458 21093383 23665236 9405685
TWIST1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18504427 15555546 15856770 11585922
RARA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10356361 24821728 21383775
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
CEBPB CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10982390 15466360 15041706
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
JUN CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11136975 12717415 21278055 10506225 19628677 12054510 18094076 10072388 18210215 10733944
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
PPARG CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19551868 19103521 19208833 16985067 18509005 15041706 15345676 16091736
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
SKP2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 32035614 25241761 23261596 17679094 15998794 17477906 19686743 16376880 15980415 18794347 13678583
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
ZBTB17 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9618481 12545156 17550342 17828269 10454538 15155580 11283613 11283614
SMAD2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9389648 9618481 12545156 17550342 11013220 15155580 9670020 11074002 11283614
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
FOXO1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12383116 25241761 8756624 29997244 16982699 7478582 10022926 32814053 15232106 16009130 16189514
CDKN1A CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23443559 26186194 21308745 9660939 8756624 15890360 9380407 8242751 8662825 12947099 9632134 17679094 26496610
CDKN1A E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
FLT3 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 17254966 28522571 19075005
TP53 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15145945 15988033 19235838 10516009 21478095 14984207 19427386
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
FOXO1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21418583 17015685 12359217 12391153 11094066 18593906 19281796 18787071 23160481
E2F1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15713665 21840777 22955272 23393547 19077036
FOXO1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11073996 19380174 10783894 20673124 11094066 15668399 17646672 21708191 15084260 21613825 17940099 11994454 11154281
TP53 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21340684 20066118 20457558 20182602 6396087
SKP2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 26450989 20160477 12820959 18805092 16209941 24085301 11565034 15071497 18239684 22959436 17409098 22524983 15147722 12529174 23910095 15998794 16189514 22310285 35247157 12813041 21503567 20663873 22632967 10559916 11516665 11463388 12140288 15688063 15469821 20160482 15735731 15355997 15340381 12042314 15075339 21237244 19686743 32265224
CDKN1B CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15583032 29997244 7478582 10022926 18692475 32814053 16189514
CDKN1B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25910212 16189514
CDKN1B CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 8684460 26186194 9660939 17254966 15890360 16209941 12947099 12501191 26496610 9724724 9311993 9716181
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
MYC CDKN2A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
MYC CDKN2A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
TWIST1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
BMI1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
MYC CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15361884 11593429 11507042 20023701 23342141 16537449 23277542 10914736 9212167 12835716 24177224 11062467 15199070 18762810 19786833 20551174 11360201 23722468
SP1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10649433 22025288 15067344 17370299 21830402 17225865 12134028 19115249 16239970
RUNX1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12732181 18276842 21757616 10851069 12091906 23673926
E2F1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11314038 12766778 20664976 10914734 16211008 10594030 11062467 11705881 11526499 15716352 19641316 21765927 22621932 19115249 11870517 12695664 20580656 15175242 17912037
TCF3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15138269 20194619
TP63 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9151818 19340300 19554267 21093383 19672307 8995628
TWIST1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22796940 20818389 17690110 15640618
E2F1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11314038 16135794 11883935 12446760 18319725 15175242 11034215
MYC CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15361884 9308237 10373560 17936558 12209154 12738781 17873522 11283613 21406394 9312026 15095404 17558397 20551172 19901969 19815509 10504341
BMI1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21383063 9308237 21678481 17936558 22796940 20818389 11283613 15640618 19404261 21685941
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
E2F1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9418871 19376752 17173070
MYC DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15021909 18483244
CEBPB DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8051100 16757577 10085237 8662954
DDIT3 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7588595 21983012 11050169
DDIT3 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18772138 22031759 17709599 15688424 21471847 18850010 17197543 15659384
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
DDX5 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15298701 17369852 20022962
DOT1L H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12123582 18022353
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15711575 12110166 20971808
E2F1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7623816 11264255 9178900 20580656 14681231 10594784 24335704
E2F1 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12438307 16931907 14645238
E2F1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16331253 23352642 22372491 24574749 20424123 17471231 23348237 17483325
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
CCND2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCNA2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15840440 16135794 9736735 15133492 15558010 15123636 9556498 12501191 16213134 11980909 16123593
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
CCNA1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17660363 15840440 16135794 18590585 7575488 17303408 9736735 15133492 15558010 15123636 9556498 10022926 16213134 11980909 16123593 11739724 15279786
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
LYL1 EP300 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18160048 21486943 15620361 11840323 27128622
EP300 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12057991 17395887 17237818 12471036
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9660747
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21875947 19270680 19158375 20587414
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15731352 20448036 10490106 9920895
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EYA1 SIX1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 15492887 28514442 32296183 11734542 12874121 33961781 26186194 15226428
SIX1 EYA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17035528 15226428 15492887 11734542 32296183 12874121
SKP2 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
FOXO1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18301748 20713551 23763570 18390843
CEBPB FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18391971 11893744
ESR1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17145710 18391971 22266855 11435445 11353774
SKP2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15340381 17522590 15147722 17646672 12820959 15668399 11516665 15071497 15688063
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
TP53 GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10749144 22801474 11221850 15031557 22262183 10321740 17700520 11420680 10094833 23114628 8892753 23948959 9405685 21394211 9931282 10435630 12007564 15721278 17440969 23576563 9566896 9233781 21836608 21245169 15186775 17063488 9154806 10327059 9191059 17344317 9519881 20797428 18350249 7624148 10566557 17084916 16714289 20840860 15735726 12806965 18225552 16581545
MYC GADD45A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15721278 9190899 10913183 15021909 14519204 9811446 21835778
TP53 GADD45A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16990795 15603758 14627995
MEN1 KMT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17145710 15199122 19075677 16618927 17671196 22936661 22327296 15640349 16997566 20818375 20961854
MEN1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11526476 16997566 16713569
MYC MAX â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC MAX â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16596619 21988832 10229200 17471507 26267534 15572685 18003922 20382893 35140242 17418410 25609649 16352593 31767764 17072308 17289033 10918583 9528857 14749374 21807113 19623651 18620061 25522242 32296183 16140957 16705173 19578763 26496610 12584560 17157259 17643117 24951594 20946988 10465786 12706874 12821782 9184233 17353931 10611234 32140074 8266081 20691906 16410719 21150319 10593926 12660246 27859590 12553908 8224841 10319872 2006410 16287840 16606833 23816886 9708738 17314511 9886493 27705803 33298911 33961781 20936779 12824180 9680483 17700062 29467282 30415952 12391307
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
BCL9 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
MYC MAX â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC PPARG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC MMP9 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC TGFB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC VEGFA â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
PPARG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11973610 17462534 16405739 19075513
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8386381 10713672 12835716 7608142 12937171 14519204 14729654
MYC CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15681429 17082780 7556187 8076602 20097210 12695333 15867211 19259613
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12447693 12695333 12824180 18437010 18483244 12545167
MYC SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24259667 12963825 12769844 23792459 21245140 24177224 23277542
MYC VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19738061 19147754 17785433 22002305 18809243 19398483 12368264 23028984
MYC MAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508165 15665468 8385351 8649388 8521822 22384171 1406956 17341548
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
TCF3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
SKP2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17145710 24259667 12963825 12769844 17157259 23277542 20852628 16376880 35260179 26038816
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
HDAC1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
MAX MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 17145710 16287840 25609649 12821782 16606833 16596619 21807113 25522242 20691906 19578763 24951594 8224841 17643117 9528857 12391307 16705173 21150319 10229200 21988832 15572685 9680483 2006410 17314511 14749374 12553908 17289033 17418410 19623651 12824180 17157259 12584560 26496610 20946988 20936779 8425218 23816886 17353931 10319872 17471507 18003922 16140957 20382893 12660246 8266081 7565735 32296183 10465786 26267534 17072308 27705803 9184233 18620061 10918583 17700062 10593926 10611234 16352593 9708738
KMT2A MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20677832 16510874
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC ZBTB17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 17145710 26766587 18923429 29137325 20426839 11283613 17418410 9312026 20697356 19786833 16352593
NSD2 PAXIP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
PAXIP1 PIAS4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
SNAI1 SIN3A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
SNAI1 HDAC1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SNAI1 SIN3A â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
SNAI1 HDAC1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SNAI1 TWIST1 â—¼   DOWN_REGULATES ✅ - 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SNAI1 TCF3 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SNAI1 ZEB1 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SNAI1 MMP9 â—¼   UP_REGULATES ✅ + 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SNAI1 HPGD â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16818638 19820419 19608733 19010907
STK11 ETV4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21150337 16912160
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
TNFRSF1A BIRC3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 35941131 22179575 22848449 23313255 24098568 34876703 16282325 20385093 22435550 18178551 19910467
CEBPA TNFRSF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19523687 20861254
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
MYCN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20811720 11107122 10050884 21862876 20145147 19885598
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 PTK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24809783 20515733 21355845 21071137 21269258 18493017 17999388 17725966
TP53 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 1346476 18234965 8554604 8898977 10745175 19714248 9988237 10029407 11096091 11172607 11920581 17952118 8679460 9112432 11350951 8502478 11483599 7949467
TP53 NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9249061 12403781 21683812 12167641 18372207
TP53 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 8108142 20639906 9377555 21325822 16684540 9833779 10910082 16835303 23449391 8521408 15860260 11971180 11559575
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16432214 20080630 17242190 20422012
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 COP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19837670 15492238 15861129 15103385 21403399
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
TP53 COP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16713569 23736031 15103385 18431400
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP53 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18431400 25241761 15855171 18206965 19857493
TP53 NFYA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 16959611 15831478
TP53 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21187340 16713569 11687965 21763744
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
TWIST1 BMI1 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17936558 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21383063 21502402 21678481 21685941 21733352 2191300 21919891 22406545 22796940 22945800 7768934 9278421
TWIST1 BMI1 â—¼   PROTEIN_INTERACTION 42.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17936558 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21383063 21502402 21678481 21685941 21733352 2191300 21919891 22406545 22796940 22945800 7768934 9278421
TWIST1 BMI1 â—¼   UP_REGULATES ✅ + 42.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17936558 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21383063 21502402 21678481 21685941 21733352 2191300 21919891 22406545 22796940 22945800 7768934 9278421
TWIST1 ZEB1 â—¼   UP_REGULATES ✅ + 37.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 7768934 9278421
TWIST1 VEGFA â—¼   UP_REGULATES ✅ + 37.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 7768934 9278421
HIF1A TWIST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18297062 18635960 23623921 21931630
TWIST1 VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17987801 16322226 16716598 13130303 7768934 15640618 11528470 9278421
TGFBR2 CCL2 â—¼   ENZYMATIC_REACTION ✅ 44.0 1.0 ACSN 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26201938 26966341 2871107 7594497 8515656
CD14 CCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
PPARG CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16155367 17255125 20663893 15659119 15531761 20473515 18226310 18060855 12110006 20508203 11606585 10930382 16105976
JUN CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19162185 18024959 18443042 14752027 22674286 23583295 19299558 12667961 10918580 19371341 26554515
SP1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10792620 10644332 17255531 8630731 10636866 16847329 10657660 23349788 12787135 12488502 12682245 25108845 8051410
CEBPB CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17180354 10748205 20019816 12145301 16784777 17390372 18649942 20730378 19026986 15710476
NFKB1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 10644332 22189654 20038977 11512674 8630731 12488502 12540607 11716760 8617886 12218154 14631383 16325549 10744656 10530453 11006087 16040075 10987310 16206198 9388261 10614622 16818736 10636866 10469356 17507908 12647268 16764699 25108845 20200316 15950427 20579762 11949945
SP1 CDKN2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18642058 15107822 22504641 12077144
KMT2A HOXA9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20677832 15941828
HOXA9 MEIS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10082572 15161102 9343407
TGFB1 ID2 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
HIF1A ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 15252039 7539918 17615296 11708773 1823643 12829734 9159130 13130303 9746763 11566883 12080085 10403805 8943284 15451019 9278421 16887934 15181457
KDM6A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24561908 17713478 20123895
VEGFA FLT1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
VEGFA FLT1 â—¼   PROTEIN_INTERACTION 27.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16076871 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
HIF1A VEGFA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21372296 21765015 22006996 22461508 22850421 22988108 23390297 24006507 25043024 25103413 25732824
CD14 VEGFA â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
ZEB1 VEGFA â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 7768934 9278421 9811054
LMO2 VEGFA â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 7768934 9278421 9811054
NFKB1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18184402 17673602 16684540 15517885 12160329 15856023 18056465 20538607 17407600 20103608
JUN VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9256279 11204570 11353786 23274526 11678207 17341624 20015448 8910439 16328781 11731421 15039660 19553068 20432243 7887961 12163680 10885623 11281649 14602779 18294451 15277220
RARA VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15613498 17470563 18326047 11804877
ESR1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16267616 12400015 17272396 18252963 18497067 10866309 19420388 19398483 16249470 14647449 15774498 12208749 10995484
HIF1A VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 186.0 1.0 Omnipath 20303950 17085645 22609851 12697836 17557905 15140752 17431122 17486380 11866451 20453883 8756616 18027712 10702253 11678207 19046997 19491109 20127031 20307196 15315159 11359907 18233956 12032158 19502554 9178256 15956714 23060442 11350893 15930297 15207747 19074414 20660740 20489156 17089387 15735682 16506055 9746763 21793044 20436213 22789427 21814878 17053163 18835464 18072084 15983061 11749701 20875806 18432192 18471962 15039660 16750526 17322369 16052307 12433987 21447827 16682453 16971129 21258402 20027628 12542982 17272396 20574527 14712484 16865543 17916562 19664474 23354733 18060642 12570801 9235919 22903062 18563715 12154035 12612059 20599538 18572865 21187066 10837481 16596228 12963476 19828020 15169887 15156561 20232316 16969516 15111179 15342781 15475194 9398602 11001829 11191064 10882714 8387214 15191799 12820439 17413038 19111391 16854277 12509854 23404377 16900513 24347168 18021292 17947829 22771629 18295594 15774498 12205045 17498666 11007955 14699103 21145972 16618748 18322419 16540671 20724477 16778202 9393757 11549290 17065555 15315937 18024476 21343542 15705785 10987301 22306343 23086815 16774940 19420388 15050899 19759417 18289162 10415537 15277220 16818499 16982770 24464787 19238077 23028984 11056102 15838297 16301840 18578647 18702304 19020709 19564336 17461470 16515634 20043814 15806152 19336759 22750006 23185615 17470361 15746177 17889387 18339855 15890092 15663958 17704802 10477681 12052835 15382039 11707426 12855680 12023962 20432243 10611972 19819950 9359410 10640274 12393646 16311927 21435239 16357173 21731766 16543242 17481912 20449875 14602779 17167225 11486006 18294451 22076197 17999410
SP1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 19671799 12509426 12560084 16638750 15342781 10910082 19147754 22992725 15217947 15737464 11904305 12429844 15688401 15544046 12615726 11678207 15188178 18021292 15883203 15477724 18454179 23652833 16239639 23369005 8910439 15026340 11007955 12644537 14597566 18575762 11232768 11731421 12482909 12570801 15582599 16540671 16790435 18632621 9264407 10581162 16788159 11040101 21115498 23765166 11060301 22326662 23506169 15613498 15970595 11191053 10816575 12975317 20435036 16949073 11980848 14647449 15302997 9271438 15039660 16982770 11559575
EPAS1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15156561 15192019 19010893 15191799 19080330 20061373 9113979 16900513 20574527 10531360 21057546 21145972 11350893 16778202 23213445 11301389 20807755 9746763 9665461 11751212 12750296 24062466 11912213 16920734 17322369
HIF1A VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7768934 11528470 9278421 17987801 16716598 12080085 10403805 16887934 7539918 1823643 12829734 13130303 15451019 9746763 8943284 15369676 9159130 11901189 22952674 11566883
VEGFA FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 15637071 9393862 8356051 10543948 21939755 8621427 16633338 21441409 35874709 8631822 14704231 17051153 20660291 26285753 22348123
TGFB1 TGFBR2 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
IL6 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26201938 26268945 27557510 7590867 8837607 9845545
TGFBR2 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR2 EGF â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16424049 16474430 16572188 17070508 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26201938 26966341 2871107 7594497 8515656
CAV1 TGFBR2 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
SP1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18053089 11507078 22028617 15647279 11687969 10982796 12750289 15895377 10766860 9632722 15905358
FLI1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10749119 14534527 10508522
TGFB1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 122.0 1.0 Omnipath 1310899 22874531 8047140 11279127 22710166 7878020 16424049 17673906 24132110 18922473 22943793 12729750 16446785 20519943 7706250 15761153 7594497 15548370 15761148 15265520 19010789 26194464 7852346 12717440 17768418 19050695 11133108 14557817 11278410 19920116 22949611 22703233 23331499 23070005 20060931 17070508 21614932 1333888 10716993 16572188 20860622 11323414 21900405 12724770 8106553 23034983 26192618 2871107 12809600 11382746 21372296 20538542 16200688 11792802 26201938 24403530 15099563 11013220 17979848 21054789 23784029 15003992 20644162 8515656 7935686 11157754 20856203 18382895 15282297 18855897 9865696 21441952 10678166 16127449 21041659 10026191 22315516 12767520 17404308 19732719 20616810 21071413 17934056 12738796 18423981 21098712 19747910 9311995 15034927 11274345 12154066 18758450 24336330 21278795 26966341 9261125 16474430 15653932 18490733 8242742 19038247 19109155
TGFBR2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10678166 9463378 11792802 11133108 19920116 14557817 11278410 15178549 20060931 17934056 21614932 8980228 9311995 20519943 21900405 15548370 19010789 15104092 16474430 30093905 11274345 9865696
EGF PLAU â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
PLAU PTK2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
SP1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23978400 10361124 21567400 21076612
ETV4 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1330539 8570190 9295342 11676474 8761947 7760840
SMAD2 SP1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
SMAD2 NCOR2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
SMAD2 SP1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
TGFB1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
CREBBP SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16751102 18003620 9679056 15750622 17283070 20403362 17074756 15231748
TGFB1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15548370 19010789 10678166 16474430 9311995 23831640 17934056 20519943 24075003 11792802 11133108 21900405 14557817 11278410 19920116 9865696
SMAD2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19558215 10878024 12631740 11013220 11114293
SMAD2 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160896
BCL9 MMP9 â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
SP1 MMP9 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
NFKB1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 17922642 15605368 14755547 20332461 18357389 17186550 11060311 18566231 9679762 16687076 17121934 18843978 21963718 18056465 20103608 17174275 15536164 19303700 17158602 7860222 19539355 9500201 19783786 18567920 15175338 17498959 10359016 18801463 19454280 19662350 12193473 16014933
JUN MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 16798740 16554298 11774399 15949416 11429784 15777790 16014933 10935492 11326313 18809380 21474819 21963718 19455716 9136992 17572495 23176293 15708369
PPARG MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20021931 22472882 22207709 9665460
SP1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8226872 24755270 18028425 9514098 9520415 23799155 20529870 21840940 7860222 17049831 21963718 18357389 9150367 11060311 19616522 11830485 9748266 20638438
MMP9 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10652271 21900405 25241761
HIF1A IL6 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10804084 15749903 16110315 16127144 16243976 16413922 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 9743347
CD14 IL6 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IL6 CEBPB â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26201938 26268945 27557510 7590867 8837607 9845545
SPI1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15013752 23509362 18680724 19502584 25567680
CEBPA IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15158360 10748205 11975924
HIF1A IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17548584 20003295 21258402 15913932 18791496
JUN IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 26513016 10542237 21069809 15389813 15158360 20225236 12667961 20371366 20511231 20862675 8453101 10202034 18502099 10037779 8830832 19687301 21098092 25567680 20351184 17341596 11120852 21312239 24676671
CEBPB IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 8441418 10748205 21069809 1327803 7543095 11004486 9312180 23595969 15389813 12853840 7651415 7744000 9523851 19026986 17332680 8786324 8910763 11250916 23361365 11114305 7821611 21127061 9516466 10816606 1730090 8234276 15044620 9282937 16784777 20511231 1427600 24472318 7818522 10903137 23874122 8336793 22558159 14600152 19632992 9661072 14530280 1421375 11160296 9182853 22895549 25382637 9378980 9648065 24012417 11866474 8725624 12177065 8752656 11035101 18955501 2112087 15613028 9442386 9199508 7744784 15688424 8346247 22074460 17955490 12706815 11594800 11120852 10435001 8325885 19782405
NFKB1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 71.0 1.0 Omnipath 17513725 18061164 12058956 24337575 19124729 15611045 11058167 9523851 15517885 12887736 15158360 7876168 17495236 25549935 17982049 15241416 18243142 9516466 2405250 18996370 8824277 18310089 24664372 15749903 10903137 16112536 14532843 11327783 18942706 11975924 20066113 16984731 10975857 11160296 19703987 22895549 10963848 10469356 22547075 17040605 11459775 17490702 19469019 8247545 11504280 15756023 10569191 10823821 20696864 12907458 19707556 16043358 11035101 12176740 11302724 8679226 8725624 22578249 8752656 17196927 17532054 12727841 18057724 7499267 10329846 9199307 9502421 19164127 11120852 24676671 11098847
TGFB1 PDGFA â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
PPARG TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 14702344 17625041 31023188 17995524 16321227 18615188 14693716 12711314 16611854 18991162
RXRA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18615188 8264664 16611854 18007025
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
TGFB1 PDGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 16474430 17934056 18403754 20519943 16607286 21900405 11133108 14557817 15548370 19920116
ZEB1 LMO2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 7768934 9278421 9811054
ZEB1 LMO2 â—¼   PROTEIN_INTERACTION 17.0 1.0 ACSN 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 7768934 9278421 9811054
ZEB1 MMP1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 28212565 9811054
ZEB1 TCF3 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 28212565 9811054
ZEB1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 28212565 9811054
NOTCH1 MEF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18988627 10082551 23331499
MAF ITGB7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14998494 17490615
HDAC1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
CEBPA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22685373 25119735 8999951 18199703
HIF1A CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17082639 19491109 17488804 21925595 23144021
PPARG CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19395102 18485432 20107546 20554962 16303327 20889551 15331599 12695526 15720834
JUN CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 18684922 16701870 24048734 14686613 24284797 15057743 12643600 17197543 11864912 10817569 12218154 22031759 17586662 10969814 19064995 12716652 27856305 25582859 17471497 22095787 16818736 23176534 14670967 18435575 16846747 19734226 16299055 14612204 18772138 19132242 12209633 15939312 16834785 11399048 11120852 25567680
ESR1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15208657 16029657 19440537 14991571 18669446 17932106
NFKB1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 9510190 12058956 11973337 18786178 17045242 15289496 16701870 19376732 19837667 9698090 17276517 11512674 19786024 20038977 10202011 15057743 15517885 12643600 11342414 7876168 15350531 18034886 11716760 11564889 11864912 12218154 12707271 10969814 12748173 14631383 16325549 17586662 18996370 19732956 17041011 10530453 18281166 12716652 16418726 12485925 16004996 9388261 8878392 17917246 10975857 10745031 10928981 16553947 16818736 14670967 18435575 12038622 15958549 17040605 8413215 21255844 22340043 1401924 9452482 16764699 11297551 15950427 15387324 15879558 16105834 11953364 15688424 18074095 8413306 11096450 16803583 10506755 11120852 10477716
CEBPB CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 23051921 10775602 17135982 8969274 17997161 18512730 21471847 24554449 14645117 15085176 17845418 12707271 12748173 19489038 22031759 8234276 19064995 8207232 16989899 27856305 11991987 19109189 17471497 19786303 16809637 16818736 21255844 19734226 24038085 18772138 19805069 20861254 18487355 11390611 15688424 10462040 16803583 8999951 11120852
MAX CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
JUN BCL9 â—¼   PHYSICAL_INTERACTION 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN BCL9 â—¼   SHARES_COMPLEX 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN BCL9 â—¼   ENZYMATIC_REACTION ✅ 78.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 11973335 12051714 12417340 12711682 15001769 15060161 15082531 15208637 15279786 15327769 15337521 15576399 15768032 15806138 15834423 16007074 16007092 16039586 16169192 16510874 16547505 16554443 16940750 17050667 17143292 17291450 17303408 17306568 17439715 17565603 17660363 17666529 17671186 17936032 18347071 18590585 18627596 19216735 19506021 19619488 19623618 19751508 19751731 19879327 19901072 20006983 20107328 20122174 20144767 20530697 20705860 20920541 20964627 21151179 21285352 21416054 21681822 21767405 22020335 22270359 22290435 22705350 22761862 23296977 23306204 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN IL1R2 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 16054035 16396903 16406505 16880536 17000779 17439715 18813803 19190345 19219074 20107231 26587781 8545107
ESR1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11477071 17963131 10037443 16679312
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
MEF2C JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9069290 9252389 10523670 11158308 7760790 10849446 12054430
JUN CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9190901 12760745 19890352 1900839 8135780 11509589 8524292 7579683 10330159 9862439 15840658
JUN PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16515541 18982462 8647095 3135941 1963081 12960165 1331936 9851700 1903195
JUN CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9486962 23385061 15574764 17182846 15737994 21069729 9511728 20531301 21029732
JUN MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 22437631 10913304 20463008 20225236 10206959 16707434 20648623 9178763 15027120 19708869 10914841 15090544 14550555 9923649 11156425 9334186 8798622 16317516 19028685 11259586 16380175 12871225 15467742 10995748 21640141 16569638
JUN PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 11901151 16001969 19783677 15238218 23523690 10668496 16007171 12057991 22472290 18294142 16339564 17556653 9830045 9988750 19825968 15994313 15772294 9620167 9686761 15525691 11356200 16256955 11234900 18097055 11980644 9705326 19522015 11278336 18282182 12086396 10811116 20237399
JUN SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283046 10411939 9178763 9988737
JUN ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 17283040 10369069 17452336 18213731 12907627 14612525 23678002
JUN EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15075211 15772294 19937979 15375216 10617690 18625220 15238218 7629150 8885243 12954631 10973489 16214953 14518567
JUN MMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9334186 15777790 23608488 8957070 1429874 14755151
ESR1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
JUN ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
JUN SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12393465 10411939 12091339
CREBBP NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21196497 11683914 11154691
CEBPB PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22473998 23934183 7557387 12524424 16431920 22610404 15110775 18694725 17242167 16054042 15158467 9950217 10862621 20829347
CEBPA PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22553076 20725087 15664998 15110775 18619497 19059241 9367890 15158467 23071089 10862621 15632071 16580992
PPARG PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11278336 16506021 19578162 20234816 10827178 14555539 11412039 19997048 20656057
PPARG MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19046432 19296842 11869069 15090544
PPARG SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16269451 15111490 15908479 11777901
RXRA PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 12763030 25609649 20211142 11877444 16504037 17579352 16713569 9065481 22205725 23331499 22363753 10854698 19147680 19043829 12591919 9568716 10882139 10935544 17980149 26260846 21478865 14587029 23711995 9121466 18217139 31547433 7838715 19047629 23275339 21833030 12966085 17312272 11237216 15888456
NCOA2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 11500849 9238002 17513608 21071413 15026545 18988627 18584035 10944516
NCOR2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15175761 16219912 20364085 15604093 17704298 17312272 23703729 9121466 19147680
RXRB PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22205725 25609649 23331499 20211142 15604093 11237216 18988627 10882139
CD14 ITGAM â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10201950 16751103 3537192 2462607
CD14 FLT3 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
SP1 CD14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11698458 17203216 12213324 7512565
SPI1 FLT3 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10734131 11672593 11964313 12032143 12803886 12811837 16283355 16418395 20510871
RUNX1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23817177 19339695 20972335 24037986 18316480 19208846 17994017 12576332
SP1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12706891 22734486 10446912 7478579
CEBPA SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17671233 24429361 14636649 20972335 12949251 14592841 12032776
SPI1 FCGR1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12393465 7869026 8035786 12130529 15304324 14734612 10820245
SPI1 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10823830 11481336 14962802 19801646
SPI1 CSF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17116688 8264604 9506963 8302571
SPI1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10523830 9858537 23056458
SPI1 ELANE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9689920 8756629 16247445 9192779 14732495
SPI1 ITGAM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8955212 19747912 12393465 19502584 9295016 15163413 8095266 25005557
CEBPA SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10397723 12091339
SPI1 ITGAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8095266 15676205
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
NCOA3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10777539 14966289 22977234 15798179 22608253 11747826
CEBPB CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17067998 8654374 10818089 15722556 15388792 17599912 12857754
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
NCOA2 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 15657427 15987788 9192892 9430642
HTT CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11264541 11607033 16456924 15994095 17500595 16713569 10823891
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 15657427 15987788 9192892 9430642
CSF2 HIF1A â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
NFKB1 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9190901 11418664 12760745 8135780 8934574 14741709 18285351 10608823
IL3 CD86 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15034038 15549123 17200410 23026134 23125331 23762788 24778133
IL3 CD40 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15034038 15549123 17200410 23026134 23125331 23762788 24778133
RUNX1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11997340 9036972 20506188 15735013 10023677 8180380
SP1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16969077 16883603 19329185
BCL9 SMAD1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
BCL9 SMAD1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
HIF1A CAV1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
HIF1A PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19106818 16397226 21149600 14507857 16818642 23144021
HIF1A CXCR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19830694 21887463 19212630 20869949 17075581 17083723 20102637 20007689 16840440
HIF1A ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12067980 20099200 17452336 19128456 17433259
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
HIF1A FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
CD40 CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
NFKB1 CD86 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10586028 15949284 19164127 15895390 18929846
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
SP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15531587 10684646 23280667 21631282 17108117
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
SP1 NFYA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18654640 9748295 9604010 18559965
SP1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15922873 10196209
SP1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16840740 17616668 17012241 15767339 23635401 10825178
SP1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740727 7585542 15831516 9626663
SP1 PDGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15297375 9453298 9321833 9351401 22964636 7499234 10364563 11823426
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18234965 7565762 10411657 23133566 10860921 9458366 17363581 7621073 8103518 10644769
SP1 NFYA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19564345 12153142 10748033 16442295 23160377 12502798 10542271 9516473 22154511 12697323
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
SP1 PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10452548 21437359 2172788 18419748 9851700
SP1 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14567977 22815527 21123453 14645238
NFYA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10393239 12427542 10446910
CXCR4 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11668182
ETV4 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11901151 24983502 21150337 11274170
NFKB1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 9266823 20669087 12471036 17673602 10827178 16210649 12466023 15517885 12622742 18294142 19618291 12067569 15655349 17556653 9988750 18973191 14988266 12871860 20103608 15555528 11082190 15234907 22001128 16820889 19766095 15997464 12349897 15387324 15368354 18057724 15547942 16624933 17767925
CEBPA PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20506344 12914528 10956548
CEBPB PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 7559624 11259631 18367585 11095928 14966110 12914528 15221958 18294142 11668179 17556653 10652293 21150337 20506344 18820298 18650268 16786175 10631313 10841183 22369775 19908286 16820889 11522796 15713664 16699180 16399783 10956548 11278846 10724331 16981245 18444174 14645533 16452236 12086405
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
NFKB1 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17513725 11313274 19164127 11027342 17031478 9733827
NFKB1 BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 15756023 9733516 12010810 18566231 16453001 20103608
NFKB1 TRAF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19343319 17673602 14991743 17018379 9733827 9733516 10823821 11297551
NFKB1 NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15811852 10777532 12150997 16846590 16382138 15494311
LMO2 MMP1 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 7768934 9278421 9811054
TCF3 PTCRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11490000 17050604 11870636 12566462
EGR2 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23155406 18396140 16054051
CD40 BIRC2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19426221 12374738 24298274 9718306
CD40 BIRC3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19426221 12374738 24298274 9718306
MITF CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14962802 11481336 17105730 11425859 10750559 11818452
RUNX1 CSF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16007221 17589498 9209363 8577711 8585955
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9990015 19581927 10603305 15509789 16431920 19663997 15110775 7862113 10854425 17301242 24216764 20179325 15158467 17646392 18622014
CEBPB ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9040943 15044620 7961962 9712708
CEBPA ELANE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17360796 19620402 8756629 16247445 12949251
ERBB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17496910 19617202 25241761 10545505 7657702 27638858 19339212 27939360 15743500 20201928 12753909 16919435 16713569 7529872 12600989 11807823
KMT2A H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12453419 20210320 24680668 29897600 31485071 20541251 24235145 20452361
ETV4 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11175365 18409049 10655108 16406575 7914192 16786139 17168666 15235125 15461591 11774202 16632435
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
ESR1 PBX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19376833 18414489
KMT2D ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 16603732
NCOR2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12738788 14715875 9171229 9702189 20392877
ESR1 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18499756 9192892 9430642 11014206 19460354 15657427 23331499 11477071 26487511 16645043 12612084 20348541 12630920 14766010 17697320 11937504 12714702 12554772 9774463
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
RARA PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7556191 19538480 12935977
NCOA2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12612084 20543827 23331499 9192892 9430642 16713569 12503607
RXRB RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 21988832 26871637 25303530 23331499 20211142 15604093 1310351 21071413 10721822 31515488 16189514 32296183 16713569 18988627 29892012 1310259
RARA RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 15528208 19345331 16713569 16769902 21988832 23331499 14521715 15604093 21071413 10828175 10698945 18988627 12393611 25303530 16224062 25241761 1310351 21478865 17641689 7760852 9415406 9121466 7705655 9582446 15171703 10882070 1314167 12052862 31700049
H3C14 NCOA3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 15986123 17463000 23723241 15345050 21445275 24973012 17666587 11103799
H3-3B NCOA3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 15986123 17463000 23723241 15345050 21445275 24973012 17666587 11103799
H3C2 NCOA3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 15986123 17463000 23723241 15345050 21445275 24973012 17666587 11103799
RXRA NCOA2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11387316 12815072 10334992 16908160 11870371 10334993 16541101
NCOA2 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 12612084 11981034 15657427 23331499 21071413 9430642 10748178 11514567 18988627 11851396 17947383
PAX3 MITF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10982026 22290434 10480898 19074888 19403660 9500554 19026785 20925909 11237412 10942418 10644012 21965087 21519923 11830592
NFYA ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18234965 22154511 9187262 16223781 7961962
KMT2D H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19219072 18022353