Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 KMT2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
JUN ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9746785 15145216
PAK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11121037
BCL6 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160044 12402037
BCL6 HDAC7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11929873
BCL6 LITAF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23795761
BCL6 IRF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10601358
PIN1 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17828269
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 ZBTB17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17828269
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
TRAF3IP3 CCT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
CCT3 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24756126 1001844
CCT3 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
YY1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22025288 18558095
EZH2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20574448
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
CTNNB1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
HSP90AA1 TRAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RAF1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
JUND MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12226747 21734453
PRKCE MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11350735
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
RAF1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
PRKCE MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16810323 16461926
OLA1 PRMT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAC1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
PAK1 RAF1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17097642 5219317
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
SUMO1 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17036045 5219211
PML JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671405 10620019
PML STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12506013 16189514
RAD23B SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
SMARCA4 RRBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
JUN SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
SIRT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27776347 28583374
SMARCA4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11950834 33476981
IL6 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
SPI1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24429361
STAT3 CSN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9195960 7519723
STAT3 JUNB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11533249
STAT3 SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11889125
SIN3A SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17036045 5219211
HDAC4 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12032081 18691969
SUMO1 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20016603 25114211
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
SUMO1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12769861 12679040
UCHL1 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
TP53 PPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SAE1 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 15327968 5217177
ZBTB16 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24821728 24821727
TP53 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23940366 9360971
TP53 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20428827
TP53 TH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16133124 19618851
KMT2B TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
YY1 TP53BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
JUN TP53BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8910340 9448005
TP53BP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16945145
YY1 CSN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8264581 8114709
YY1 PSMB4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
TRAF2 PIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PIN1 NANOG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20622153
STAT5A CSN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15534001
PRMT5 TRIB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
TRAF2 IRF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRAF2 ZBTB16 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ZBTB16 IL6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EZH2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19687301 16007202
PRKCE RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11350735
ZBTB16 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
HDAC3 GATA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0607926103 17075044
AR SIN3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16254079
KDM2B JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17704768
JUN IL32 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18239058 22413812
JUN JUND â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8922393 2504580
JUN PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16729332 20143420
IRF4 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22446486 16272311
IRF4 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21890374 12374808
IRF4 FCER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11342629
GATA3 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22446486 12027437
ELF1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9121484 8943338
STAT6 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15145939 10373589
AR IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23554843
STAT6 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20956546 22841009
AR TBL1XR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24243687 20610535
ZBTB16 TRAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TRAF1 ZBTB16 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
HDAC5 GATA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0607926103 17075044
CTNNB1 NANOG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
TLE5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20676368
AR PPA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18212046 20610535
AR GOT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8843413 20610535
EZH2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24457600 23239736
KDM7A AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17277772
MBD3 ATF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TALDO1 CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
CHD3 FUBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ZBTB16 RUNX1T1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10688654 11090081
GATA3 ZBTB7B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19729201 18776904
TCOF1 SSB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TEKT4 TRIB3 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
CHD4 EZH2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
PHB2 HDAC5 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 21081666 15140878
PML EZH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17560333 27634302
SUMO1 SIN3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17036045 24654937
CRBN CSN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24292625 27029275
MBD3 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 25123934
JUN HDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17056544 25609649
EZH2 HDAC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23079660 21685935
JUN CHD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21196933 25609649
RAC1 SFXN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
ECH1 TRAF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25416956 25996949
PHB2 SFXN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31536960 34079125
CTBP1 EZH2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31041561 27634302
ABL1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
BACH2 PATZ1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 10669750
HDAC1 EHMT1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26496610
EZH2 SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24981860 27634302 27705803
HDAC4 SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17011572 10220385 17210713
JUN JUND â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25609649
EZH2 CHD4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28486105 28068325 24981860 26344197
CTBP1 CHD4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 31041561 24981860
AIP HSP90AA1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CHD4 SMARCA4 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CSN2 JUN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16045761 25609649 10903862
MED23 CDK8 â—¼   PROXIMITY ✅ 0.84 0.84 mint 25281560
CHD4 CHD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28977666 32744500 24981860 22939629 9885572
EHMT1 CTBP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 31041561 16702210 33961781 26186194 12700765
MED23 MED17 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 25281560
SMARCA4 TP53 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
HDAC1 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
HDAC3 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
MAPK1 RAF1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
JUN PML â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
PIN1 PML â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22033920 18039859 21840486 20100838 24586174
HDAC1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15653507 22750444 15870198 22116549
TP53 PIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 12397362 5215850
PIN1 RAF1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20179103 20179161 15664191
SPI1 JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12091339 9681824
ATF7 JUN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CHD3 MTA3 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SIN3A ZBTB16 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CHD3 MBD3 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
HDAC9 BCL6 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16147992 12590135
BCL6 TRIB3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16147992 32296183
RAD23B PSMD4 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 20059542 7307429
RAC1 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16189514 11021801
NACC1 HDAC4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16033423 28319066
HDAC9 HDAC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12590135 16611996 10487760 10655483
GATA3 MTA3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34026424 26028330
CCT3 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT4 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CCT7 PFDN5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
HDAC1 YY1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
BCL11A HDAC1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CREBBP STAT6 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CSN2 SIN3A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10207062 15173382
PHB2 HDAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24051437 15173318 15140878
GATA3 HDAC3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 29453984 17075044
JUNB ATF7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 20102225
MTA3 CHD3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12705869 28977666 24981860 26344197
MED6 MED23 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10993082 33961781 25281560
CDK19 MED17 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15175163 33961781 24981860 23749998 26186194 23602568 32707033
CDK19 MED23 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 32707033
CDK19 CDK8 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
KRTAP19-1 TEKT4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CDK19 MED17 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK19 MED6 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CHD3 CHD4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
MED17 MED6 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
TNFRSF8 TRAF2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HDAC1 RUNX1T1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IRF4 BCL6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10601358 11342629
STAT3 PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12506013 16189514
PML HDAC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11259576
JUN STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10490649 16713569
CSN2 CUL3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 26976604 33961781 21145461 19295130 16045761 32047038
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
HDAC5 HDAC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10869435 10220385 11466315 11931768 11804585 21081666
SIN3A HDAC9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12590135 11959865
IRF4 STAT6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10601358 11342629
JUNB JUND â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781
HDAC1 SMARCA4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HDAC3 YY1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ACO2 GOT2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CUL3 KLHL12 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HDAC1 BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15454082 9627120 9753732 16147992 10611298
BCL6B BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25416956 12659862 9632807
HDAC4 BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16147992 11929873
HDAC5 BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16147992 11929873
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
PML JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15626733 9671405 16916642 10620019
PIN1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29225075 11432833 16713569
GATA3 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29453984 34026424 26028330 31409898
HDAC1 CHD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 23752268 9804427 20585571 28977666 27068747 26496610 33961781 17827154 22939629 9885572 11784859
HDAC1 SPI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14647463 16331260 11593411
HDAC1 MTA3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12705869 23752268 28514442 34026424 22075476 26028330 26496610 21258344 33961781 24981860 18451879 26344197
HDAC3 HDAC9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12590135 10655483 11466315
JUN ATF7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25609649 26496610 20102225
IRF4 SPI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12372320 10022840
CTNNB1 AR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5216126 12588987
MTA3 CHD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22075476 26028330 32744500 21258344 24981860 28977666 26344197
CHD3 MBD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 28977666 25123934 24981860
CDK19 MED6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 32707033 26344197
HDAC9 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11022042 16713569 20361981
MTA3 MBD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12705869 25123934 26028330 21258344 24981860 26344197
CDK8 MED17 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
SIN3A BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16147992 9765306 9753732
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
BCL6 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21106671 12594267 15507530
MAPK3 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9649500
PATZ1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19340300
BCL11A CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
GATA3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
STAT6 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
CHEK1 E2F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19917728
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
MAPK1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
SPI1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22075620 10727414
MAPK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
WDR83 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15118098 23331499
MAPK3 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15093545
MAPK3 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14993270
PAK1 RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17097642 9823899 12551923 10205168 9234708 11733498
RAF1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
SUMO1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11948183 16189514 9885291 19015637 21305000 23028697 28851805 23604351 15017387 22155184 21057547 19380586 24190887 20826694 20972456 23830076 17027752 24654937 25497731 9756909 21779164 31879127 17081986 18625722 8806687 17081985 17344210 19217413 17036045 18474224 9452416 20188669 16501610 22406621 22875967 9427741 15561718 21098080 11080164 11160742
PML IL2 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 17928811 19218564 20452955
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
STAT3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20830236
STAT3 JUNB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10497240 17204573 9325164
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
SUMO1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
AR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24119295 21796528 17932034
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
TP53 ATF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18371449 20631301 15619621
YY1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9238849 21852380
HDAC1 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18634613 11486036 11940654
PIN1 KMT2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HSF4 NUDT21 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TRAF1 TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10544141 25241761 20385093 14557256 21903422 14743216 32296183 29748372 11181075 15383523 8702708 8069916 19287455 16713569 9718306 25996949 9500555 33961781
ARHGAP35 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 1894621 10873807 32203420
CTBP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 9650586 16189514 23752268 31041561 16713569 28947780 10995736 34147029 18765668 11022042
CHD4 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25247294 32744500 21258344 11102443 28977666 9885572 26496610 20585571 10220385 22075476 21670149 22939629 23752268 27616479 9790534 9804427 26949739 20693977 33961781 24981860 12920132 26344197
MBD3 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10444591 21258344 11102443 12354758 19041848 27068747 26496610 25123934 24048479 21670149 17827154 22939629 23752268 12124384 16428440 33961781 24981860 26344197
SIN3A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15695521 28514442 9520398 10640275 14647463 12398767 9150133 10444591 14593184 21258344 12943729 12374985 17956988 11102443 9885572 17962807 26496610 12453419 11171972 16331260 20585571 10220385 25314079 12091390 11931768 17643391 11602581 17827154 12724404 11784859 23752268 18059533 9790534 9804427 26949739 24981860 33961781 19182791 11118440 15451426 12920132 26344197
CUL3 HDAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 15467454 15688063 17312394
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
HDAC7 HDAC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23752268 16189514 11466315
HDAC3 HDAC4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31040226 10220385 10869435 11466315 11804585 17956988 27684187 18558095
HDAC3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16528103 18241676
IRF4 IL21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20697158 19062315 22983707
SPI1 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19592658 11150515 21957289
JUND IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1737937 7989759 11685114
CREBBP HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10777539
EZH2 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24108699 21624129 16009709
ARHGDIB RAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDK8 MED23 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18418385 29568061 26496610 20098423 11416138 23322298 33961781 25281560 26186194 23602568 32707033 11867769 10353252
CDK8 MED17 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 29568061 26496610 20098423 33961781 24981860 26186194 23749998 23602568 10198638 11867769 10882111
STAT6 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17312100 12947222
AR CTNNB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
AR TH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16356647 20610535
MBD3 CHD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25123934 25247294 28977666 32744500 24981860 21670149 22939629 12354758
E2F3 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18319725 14532106
CTBP1 CHD3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GATA3 FBXO11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
GATA3 WTAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
GATA3 ARNT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19559773
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK19 MED23 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CDK8 MED6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
HDAC1 ZBTB16 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
HDAC1 HDAC9 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
CCT3 TRAF3IP3 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CHD4 MTA3 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
CHD4 MBD3 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
HDAC3 HDAC4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
HDAC3 HDAC5 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CDK8 MED23 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
PSMB4 USP14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
SUMO1 JUN â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 10788439 15469925 11867732
CHD3 HDAC1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
HDAC1 MTA3 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
KIAA0368 PSMD4 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
MBD3 MTA3 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
EZH2 HDAC1 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
JUN JUNB â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 33961781 25609649
MED6 MED17 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 26344197 33961781 24882805 24981860
HSP90AA1 RAF1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
SUMO1 SAE1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9920803 20164921 15660128 19246003 12941704 12924945
EZH2 HDAC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 21685935 15520282 10581039 24771265 31130994 22439931 26344197
MCM4 MCM3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16902406 12614612 27621311 33961781 30108253 22939629 26344197
ABCE1 ETF1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CREBBP SUMO1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CHEK1 TP53BP1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
MED6 CDK8 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 29568061 10198638 10024883 15808511 26496610 11416138 33961781 24981860 26186194 23602568 14983011 26344197 11867769 10882111
HDAC1 MBD3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
PML SUMO1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RAC1 PAK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5217506 15688026
SAE1 SUMO1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TP53 TP53BP1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TRAF1 TRAF2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PAK1 RAC1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 24625804 19327867 15143066 9535855 17245428 11134022 15673687 15289329 16492808 16551621 21029865 16678097 19596003 26175416 17389360 31871319 24056087 25843002 25150978 12879077 15212766 19693014 11030651 16630611 20810653 8107774 11130076 25468898 29615491 19732720 19270716 21474670 10706722 19277120 10802735 21167153 24172987 21454543 15548653 16002993 12650940 18426980 19961560 11950930 24792722 15688026 7744004 20936779 25819133 15075243 22581261
PSMA1 USP14 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ARID1A SMARCA4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PSMD4 RAD23B â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PAK1 RAC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD4 USP14 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MCM3 MCM4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PSMA1 PSMB4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMB4 PSMD4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMA1 PSMD4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
AR ABCE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
ABL1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19818398 18619508 10637231 20841568 14757045 15302935
ABL1 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8940193 20841568
ABL1 ARHGAP35 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15084284 20841568
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
ABL1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24836440 8940193 20841568
ABL1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8940193 16846476 20841568
STAT5A BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16819511 15711548 20498019 20124477 23716595
SPI1 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19564417 15892171 31000603
BCL6 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12097386 11374866 9110977 10490661
BCL6 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19337254 18648506 15509806 22723377 17392284
MAPK1 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9649500
FBXO11 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 31743519 22113614
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
E2F3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18663357 15175242 11883935 19340300
JUNB CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16966326 19340300 17370299 10856241
EZH2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19954516 21572997 23289480 23826727
E2F3 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15177020 15175242 18319725 11883935
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CHEK1 MCM4 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM4 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM4 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
HSP90AA1 HBEGF â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8617201 16978839 10878805 15643424 15568014 1973074 8665853 11071886
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
HSP90AA1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 25036637 19011619 16093354 8962087 18266962 8408024 23118896 22939624 24462205 16189514 17699868 20039095 16504566 20159553 17409432 16330544 15618521
RAF1 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9804779 25241761 18775330 10194762 8226933 10996427 9604935 8388392 12091337
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
MAPK1 TH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 1973163 7901013 1347949 23321789 23970867 14570886 19945993
MAPK1 JUND â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17570479 22327296 14676207
MAPK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17081983 18767875 15849194 19690332 11409918 14654779 23331499 23180781 8226933 20068231 18988627 21917714 18669648 19541618 18691976 16407412 19933846 9922370 15664191 8388392 19651622 10801873 8349614 18775330 9604935
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19604315 15542607 16964243 15212693 11604394
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
MAPK1 PRDX6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28055018 19140803
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
RAF1 MAPK3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MAPK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9804779 20508164 23331499 24263804 18775330 10194762 12407017 8226933 17502367 34188118 9604935 18988627 31932645 8388392 12091337
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MAPK3 JUND â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22327296 14676207
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 TH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 1973163 7901013 1347949 23321789 23970867 14570886 19945993
MAPK3 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 14654779 23331499 19541618 18691976 16407412 19933846 9446616 9922370 15664191 18988627
PLCG2 PAK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19124833 9989831 15548136 19574218
RAC1 PAK1 â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 130.0 1.0 Omnipath 17145710 15229651 21167153 8107774 24792722 16551621 14579272 10023776 8805275 18325335 11134022 19693014 19277120 21474670 12650940 15673687 19961560 20711231 11950930 16678097 12123608 19270716 9744077 9148763 11689432 23331499 21029865 16368433 11121431 16492808 15075243 21454543 10592173 24172987 15212766 7493928 10793146 21070974 10706722 8910277 17245428 25819133 20936779 11030651 9989831 15157156 9535855 19359598 25150978 16049136 18854161 19628037 15688026 12879077 7744004 11728826 16002993 9764820 9032259 25843002 10224076 19732720 19596003 10802735 19893577 16212495 11130076 12480336 11152757 19327867 22117219 22581261
PAK1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 28007610 12872159 16999872 18354494 20361981 23291169
PAK1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 28007610 28423670 23543898 25639486 26547035 22369945 23162742 25472536 21822311 25225063 27713506 27910850
PAK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 28007610 19421139 26333361 22096607 15849194 12952546 30197477 12551923 23162742 25733387 17097642 22105362 18465753 23331499 24924700 10801448 26257058 21917714 12719581 11376654 25843685 15664191 19165420 23576562 23506953 10205168 24505617 28415790 18775988 22983922 9234708 12952943 16129686 25472536 11733498 11948406 9823899 11897507
SUMO1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22875967 9756909 25497731 17036045 21057547 18931695 19217413 8806687 16189514 17081985 11080164 11948183 9885291 19380586 17344210
SIRT1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15205477 15744310 15989956 18687677 19590512 19960022
SIRT1 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23142079 21633182 19553684
SIRT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15744310 20640476 24003218 19553684
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
SMARCA4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11532957 14964309
IL4 STAT3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 IL21 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
IL4 STAT3 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL21 STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
IL6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
STAT3 IL21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26170288 18209077 17884812 20493732 15178704
STAT3 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22927445 22363173 19797626 22547075 18765795 18616672 23954444 20493732 19751774 22105366 10391682 24315995 20930550
PRKCE STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24703937 21406403 17875724 20350291 19567682 21480396 20228845 27102301 17583567 16418226
IL6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 26291658 30185178 20185553 28222632 11322950 30143645 27074565 28687744 21538419 16278387 28128332 24496235 26166037 21625597 20371721 25750173 29330478 19962667 26010889 24513872 29702530 25881314 24078775 27866206 24619648 27840174 19380824 24661007 11728826 21619877 11056211 17142955 26417930 29270528 18611949 25452693 27795451 16520748 26843613 29807795 21442031 26893580 26061710
RAC1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 26430964 16189514 11021801
SUMO1 HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11960997 12032081 15199155 24068740
SUMO1 SAE1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 9920803 20164921 19107418 10187858 11481243 20501649
SUMO1 ZBTB16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17498654 18348865 14527952
YY1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10787423 10634504 8816507 10505791 18391986
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
TP53 LITAF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10321740 21836606 17283168 15197774
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
FBXO11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 17098746
TP53BP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25579814 12110597 25837623 16713569 14978302 22653443 26022179 27546791 8016121 12351827 15611139 15364958 14985081 19433796 17805299 25651062 11877378 17634560 22084066 20307547
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
PIN1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12397362 12388558 17906639 12397361 21741598 16713569 24982848 21900206
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
PPARGC1A YY1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
GATA3 YY1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 18533032 27062924 21151129 16009131 16087863 16980581 21934649 16113099 18358809 22056668 23172872 15282324 21878914 23192763
PPARGC1A YY1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PPARGC1A YY1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
HDAC3 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11486036 9346952 17925399 16189514 18940814
PIN1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 11432833
PIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16713569 11533658
PIN1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19933846 12932319 23487407 15664191
STAT5A CSN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 10993888 9341115 8274437 8830676 12746331 19490989 9973262 12060651 18583090 11751614 16973758 10471471 1491685 10418993 15746097 10358045 11604235 18024957 23313770 9252424 12596040 15534001 9806359 9231797 12954634 11167825 11287629 12459499 10732325 7519723 9817603 14646587 8018556 12082616 10834938 12605675 9657743 12732616 8264581 8943229 20980837 16832345 16965262 9343435 11158330 7514531
TRAF2 TRAF1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 8910423
TRAF2 TRAF1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 8910423
TRAF2 TRAF1 â—¼   ENZYMATIC_REACTION ✅ 49.0 1.0 ACSN 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 8910423
TRAF1 TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8702708 15383523 16713569 8069916 21903422 25996949 9500555 14743216 11181075 15323523 25241761 14557256 20385093 32296183 10544141 12887920 19287455 8548810 9718306 31515488 29748372
TRAF2 TRAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8702708 15383523 16713569 8069916 21903422 25996949 9500555 14743216 11181075 15323523 25241761 14557256 20385093 32296183 10544141 12887920 19287455 8548810 9718306 31515488 29748372
IRF4 IL6 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 7594497 9743347
SPI1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15013752 23509362 18680724 19502584 25567680
JUND IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10037779 11337499 11886848 12727841 24676671
AR IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12237244 8824277 19074897 11049111 17374439 11410519 20610535 19363165
JUN IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 26513016 10542237 21069809 15389813 15158360 20225236 12667961 20371366 20511231 20862675 8453101 10202034 18502099 10037779 8830832 19687301 21098092 25567680 20351184 17341596 11120852 21312239 24676671
JUNB IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20221401 11337499 12070012 7836389 10497240 19918056 8537375
JUN RAF1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
WDR83 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15118098 23331499
HDAC1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC3 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11302704 16189514 23213415 10944117
HDAC1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11994312 16713569 15640443 12612053 10428808
HDAC3 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 TBL1XR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 TBL1XR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
JUN IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8996240 10772943 9889198 9133600 21989417 9310836 15546613 21454593 12594266
JUN IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 20557936 12370343 10700231 12884855 8436291 9541574 8397339 1737937 9605137 8683110 21832163 9590239 7989759 9774418 16116194 8473495 8114694 10878360 10320367 9233628 7642615 17097050 7565732 8468462 8660843 7739550 8051409 1740667 19181930
JUN SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283046 10411939 9178763 9988737
JUN HBEGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12791271 7649477 15761212 9111309
AR JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11577103 11518798 9211894 8798722 16713569 9591784 17721441
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
JUN SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12393465 10411939 12091339
MCM4 MCM3 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
MCM4 MCM3 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 7575488
IRF4 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11956291 26278622 19592658 21890374 21957289 12374808
STAT5A IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9817603 24587342 7479881 8683106 24550509 10022878 8943338 9121484 17911616 22854263 17182565 11435608
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
CREBBP STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509556 15695802 11574547 10454341
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
IL4 STAT6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
IL4 STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
STAT6 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 9317131 10369418 9647237 12605697 11687571 20980261 10528163 23913966 12244176 10373589 9786931 12138096 22226123 16647686 17878383 8816495 20620946 21081493 23727894 17041005 9295035 12778491 14993689 9199300 21949021 12218118 8760793 19419769 10820389 16914450 15695802 11150515 20225206 15922518 12082548 8624821 20214667 10364072 9110977 11544308 17433443 17645498 25037220 19604304 15728480 9845517 18400747 12776189 10982806 16084752 20828825 21751242
GATA3 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 22226971 21536806 19881507 11093124 20636338 15941711 9846495 22039304 17277157 11893731 16266280 12876556 9442389 11336690 15832295 23232398 17658278 26840450 18167455 25037220 9780145 25861992 21989417 21131966 9780146 16498264 10894164
STAT5A IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10421786 23727894 18820682 17041005
IL4 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24508458 18852293 22142941 29925830 17306571 25428220
PLCG2 RAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17540168 11278486 11804587 12670394
RAC1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19751508 28626389 26403202 19417647 22270359 16212495 16940750 12480336 11152757 29497040 30650643 19020303 15377999
STAT5A CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11160217 12586844 14660677 15509806 22723377
CTNNB1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
AR CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18535113 18673534 20610535 11916967
AR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 21741601 16713569 12799378 12944908 10809237 23331499 15060161 21071413 21885566 18988627 16428447 11916967 12588987 11792709 10987273 14593076 15256534 22187462
CTNNB1 HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12107263 11266540 23331499 15055546 16442529
AR ZBTB16 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15334066 20610535 16637071
STAT5A GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10674400 7744007 8732682 11092411 12683938 18388193 22698918 19819986 22166977 11564677 14532269 17412814 12970402 10373481 15677453 10803577