Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
SP1 APEX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18208837 7534297
APEX1 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10671489
ARFGAP3 PRDX6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FN1 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
TP53 CASP10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14688482
TP53 CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14688482
CTBP1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21681822
SPI1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22472882 19423615
TP53 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15230856 8732672
YWHAE HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10737771 5212359
RARA NFE2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709483104 18048326
NFE2L2 PRDX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18973804 23815338
TERF1 NME1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11701125 5214767
SP1 NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8961265
RARA NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10772826
OTUB1 SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 PARK7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23447676 23149933
PPARD VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11821020 16115476
SP1 PRDX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22113199 10395907
PSIP1 PRDX6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11677226
SPI1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22105598 12032776
RYBP SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SP1 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11133225 7499419
TERF2IP TERF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
TUBB4B UBE2V1 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
CTBP1 H2AX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
RIPK4 CUL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26972000 29435596
SODC GSTP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31536960 29128334
SODC PRDX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31536960 29128334
AGR2 PRDX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31436131 30575818
GPX4 PRDX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21988832 26344197
VCAM1 GSTP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
PARK7 PRDX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31536960 29128334
VCAM1 PRDX2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 PRDX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 VDAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
HDAC6 CFTR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31501480 14675537 22069321
CFTR PRDX6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 31324722
CFTR PRDX2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 31324722
OTUB1 PCNA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18954305 26752685
PRDX6 PCNA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26030842 20849852
PCNA APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10559261 11601988 16189514
CUL4A CUL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17079684 32235678 21145461
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CASP10 CASP8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HDAC5 YWHAE â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
PARK7 SODC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24981860 29128334 24947010 31536960 20406884
PRDX2 SODC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22939629 26344197 29128334
HDAC5 BCL6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16147992 11929873
RARA SP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10361124 19401466 16713569 18270252
H2AX OTUB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 APEX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18208837
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
SP1 CDH3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19882246 9328434
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
TP53 GSTP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18505928
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
NCF2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16778989 10400704 27558335
SPI1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22075620 10727414
S100A9 NCF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23980663 22808130 21239714
NCF2 PRKCZ â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
SPI1 NCF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20025940 10570299
NFE2L2 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15998244 16339837 12370194
TP53 NME1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12669312 16440314
PAX5 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8521821 22105368 21319196
PAX5 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10688639 11179673 21549805
PPARD YWHAE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17303761 18678619 17409426
PRDX6 RAB28 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
PCNA H2AFX â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA H2AFX â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
DYRK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 29296831 21383696 14749479 11740489 20171273 25778922 15843377 33906076 10581258 15750624 15897882 15706352 26236013 24899407 33572115 17906639 20935676 24379358 17386256 15870257 26346493 12427754 34103685 17567906 11101524 17210684 18536714 15381073 19965871 26578795 26087959 28060750 21765464 20673369 34216619 16601678 17380123 33443163 18216278 21642861 15526030 22878263 17349959 16738336 20696760 19882354 16219768 17105820 16793543 17332358 24901999 16247456 24196445 26804244 15657359 27208501 18056705 21765463 23420876 22797063 16377624 19861417 18160537 12676607 20123963 15489221 17591690 20514025 23149944 19857493 17891183 27034505 11780126 21057547 25944899 26341817 17349958 20962272 22525275 19828042 12902982 19465479 15471885 15322239 11495913 12907596 32083004 25915850 20018442 24145406 26029824 21394211 12093737 33872315 20610713 20024960 26113041 20811699 18560558 21660965 16717128 11030628 17107963
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
APEX1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18786561 19180539 9119221 19737086 16713569
SPI1 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19564417 15892171 31000603
MAPK1 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9649500
CASP8 CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 22864571 17159907 17145710 12887920 11832478 11717445 21737330 15280356 12198154 3031469 15659383 170210 8962078 22421964
MAPK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 24342355 17290218
CTBP1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15169839 17615296 21416054 22796940 20818389 21685935 22370643 20519943 12508111 17508028 11309385 19597490 14673164
SP1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15908479 16341057 9671487 1845987 8803927 2542772 7565693 15608673 9566920 1404598 2170405 10421838
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
SP1 GSTP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19856314 11606500 22425687 8557630 11967987 22580340 12502798 11960994 11481261
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
NFE2L2 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19454702 23708697 17467702 21808062
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
PRKCZ MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11035106 12942541 23109003 12900386 15721486
MAPK13 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK1 PRDX6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28055018 19140803
MAPK1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11883936
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK13 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15187187 19436832 15140942 10581258 20506250 21614932 16393692 24818748 11274345
NFE2L2 SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22493435 24417315 22245129
NR4A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23071566 17139261
PRKCZ SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23148884 16943418 18258854 19464346 27320013 17049555 20953893
SP1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740727 7585542 15831516 9626663
SP1 SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8921911 18586551 18608091 21056687 24946209 11724400 9867871
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
SP1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12706891 22734486 10446912 7478579
TP53 FN1 â—¼   KO_UP_REGULATES ✅ + 2.36 2.36 PKG 28854368