Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
H2AX H2BC14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AX ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19146767 11673449
ATM H2AX â—¼   COLOCALIZATION 2.0 0.8 intact 16858402 5218840
H2AX NHEJ1 â—¼   COLOCALIZATION 2.0 0.8 intact 6175821 18064046
H2AX TRIM28 â—¼   COLOCALIZATION 2.0 0.8 intact 8149296 21317870
H2AX FANCD2 â—¼   COLOCALIZATION 2.0 0.8 intact 7906544 19609304
H2AX PALB2 â—¼   COLOCALIZATION 2.0 0.8 intact 22193777 8329239
H2AX SMARCA4 â—¼   COLOCALIZATION 2.0 0.8 intact 7914327 20224553
H2AX RAD51 â—¼   COLOCALIZATION 2.0 0.8 intact 8149296 21317870
H2AX XRCC1 â—¼   COLOCALIZATION 2.0 0.8 intact 19851285 7542621
H2AX PPP2CA â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8209912 18758438
H2BC14 H1-6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC21 H1-2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC21 ENO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ERO1A P4HB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212958 10970843
MRE11 ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
MRE11 FANCD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7906544 19609304
MRE11 RBBP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21052091 8081463
LEF1 MRE11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20956948
PARP1 MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18025084
H1-2 RNF20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H1-2 HSP90B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H1-2 BAZ1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 H1-2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18250087
H1-2 LIG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18250087
ANXA2 C16ORF87 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ ALDOA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
SLBP ALYREF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23804756 2017161
PRKDC ANXA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ ANXA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
ATM YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ATM RBBP8 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ATM EYA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19234442 19351884
ATM EYA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19234442 19351884
HMGA2 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21339738
XPC ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16849332
ATM HERC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20023648
ATM HMGA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21339738
BRCA1 ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
ATR RBBP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
ATR SYCP2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19146767 11673449
ATR SYCP3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19146767 11673449
ATR BRCA1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 23422745
ATR HERC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20023648
SMARCA5 BAZ1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19092802 19234442
BRCA1 SYCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9008167 19146767
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
FANCD2 BRCA1 â—¼   COLOCALIZATION 2.0 0.8 intact 11239454 5213674
ELAVL1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19010922
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
PIAS4 CALR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ERP29 CALR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CALR YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PPP2CA CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20133759 0914492107
YWHAZ CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215799 12361576
CTSD SUMF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR1 CTSD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 6771293
DHX9 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
DHX9 ZC3H18 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DNMT1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
MATR3 DZIP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DZIP3 SSRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18206970
EEF1B2 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
EIF2S2 EIF3L â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PABPC1 EIF4A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0914856107 20133758
YWHAZ EIF4A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
ESR1 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16511840 23038705
HSP90B1 EYA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PRKDC HERC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20023648
LILRB1 HLA-G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19583775 7144930
HNRNPH3 HNRNPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
YWHAZ HNRNPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
HNRNPAB HNRNPDL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HNRNPC SND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HNRNPH3 HNRNPD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
HNRNPD HNRNPDL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HNRNPDL NONO â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RPS3A HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
YWHAZ HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
HSP90B1 LIG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ HSPA1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
HYOU1 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA5 LIG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA5 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
HSPA5 SUPT6H â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA9 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
HSPA9 TRAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
LDHB YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PRKCB MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12917261 9891069
MATR3 S100A4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NHEJ1 XRCC6 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
WRN NLRP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217546 15733840
NPM1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ P4HB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
P4HB PRDX4 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 2.0 0.8 intact 8090267 21057456
PALB2 POLH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24485656
PDCD6 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
PRDX4 PDIA6 â—¼   COLOCALIZATION 2.0 0.8 intact 8090267 21057456
PRDX4 PDIA6 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 2.0 0.8 intact 8090267 21057456
YWHAZ PGK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
XRCC6 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
PKM YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ PPIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
RPS15 PPIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP2CA RPS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15950189
YWHAB PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
PRKDC RNF8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ PSMB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YBX1 RBBP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20596676
RNF8 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20385750
TXNDC5 RNF20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAZ RPL19 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ RPLP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
RPS18 RPS15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SOD2 RPS3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SMARCA4 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20129940 8009769
YWHAZ SSB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
YWHAZ STK11 â—¼   COLOCALIZATION 2.0 0.8 intact 8329523 22575644
SUPT6H YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
SYCP3 SYCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20634189 15125634
XRCC1 TDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19851285 7542621
TERF2 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 21824286 8202878
TKT YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
TP53BP1 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
VRK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22621922
TRAP1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
TRIM28 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
XRCC6 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
YBX1 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
RPL23A RPS2 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
RPL8 RPS18 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
EIF4A1 RPS28 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
EIF4A1 RPS10 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
EIF2S2 EIF4A1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF3L EIF4A1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF4A1 RPS6 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF4A1 RPS3A â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ATM RBBP8 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 10910365
EIF4A1 RPS5 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
EIF4A1 RPS2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
EIF4A1 RPS9 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
EIF4A1 RPS15 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
RPL23A RPL8 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
RPL19 RPS16 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
EIF4A1 RPS18 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
RPS16 RPS6 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
ATM WRN â—¼   PHOSPHORYLATION 0.8 0.8 Signor 10608806
HNRNPA1 HNRNPDL â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
RPL8 RPS9 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
ATM EXO1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 20019063
MRE11 H2AX â—¼   COLOCALIZATION ✅ 0.81 0.81 mint 22157895 8303386
RPL19 RPS6 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
MDC1 UIMC1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
ESR1 YWHAB â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
MCM2 SSRP1 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
EIF3L RPS10 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
EIF3L RPS3A â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
NSD2 BAZ1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22751105 31248990
H2AX CALR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20000738 16522924
PRKDC MRE11 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 10608806 20808282
APBB1 HERC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MATR3 BTF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33644029 26344197
TKT CALR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24981860 26344197
ESR1 DHX9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 19805454 21182205 20348541
DHX9 XRCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30585729 15723802
EIF3L RPS6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
PAK1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12374744 16452229
KDM4B ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30418174 21502505
ESR1 HYOU1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25604459 19805454
ESR1 PRDX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25604459 19805454
ESR1 NACA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
HEXA TERF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STK11 KDM4A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
VRK1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28927264 34079125
UIMC1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34079125 25252691
TKT PGK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24981860 26344197
SSRP1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RPL19 RPS2 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EIF3L RPS2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
EIF3L RPS15 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
RPL23A RPL26L1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
RPL19 RPS3A â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EIF2S2 RPS27A â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
RPL19 RPS9 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
RPL19 RPS18 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
HSP90AA1 STK11 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
ATM MDC1 â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 12607003
EIF4A1 RPS16 â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
EIF4A1 RPS27A â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
CALR GANAB â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
EIF3L RPS27A â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
NSD2 PARP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22751105 31248990 34079125
NSD2 ESR1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24101509 31527615
MCM2 H2AX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 25963833
H2AX EYA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 27795300 19234442
BRCA1 TERF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 25184681 29656893 34112789
ESR1 DHX30 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 31527615 21182205
MATR3 DHX9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29884807 26496610 29511296
DHX9 TOP2A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15034300 12711669
HERC2 EIF3L â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 29426014 30279242 25476789
ESR1 PDIA6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 25604459 31527615
RNF8 NONO â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 34017080 30445466
PARP1 SNAI1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21577210 29331416
TOR1B TOR1A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15147511 33961781
RPS15 RPS2 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
BRCA1 RBBP8 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 16818604
RBBP8 BRCA1 â—¼   RELOCALIZATION ✅ + 0.83 0.83 Signor 24832651
RPS2 RPS6 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
ANXA2 S100A4 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRCA1 FANCD2 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 12485996
BTF3 RPL19 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BTF3 RPL8 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FANCD2 RPS27A â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
RPL26L1 RPS2 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
RPL8 RPS6 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
NHEJ1 RPL23A â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
BRCA1 UBE2N â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
NHEJ1 ATR â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
HNRNPD HNRNPDL â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
EIF3L RPS5 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
EIF3L RPS28 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
RPL19 RPL8 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
PRKDC BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25223785 10608806
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
WRN DHX9 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 17498979 15995249
EIF2S2 RPS2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ESR1 SND1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 20348541
ESR1 PTCD3 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21182203 31527615
HMGA2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 18850631
MDC1 RAD51 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28973861 16186822
PRKDC PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20085707 16794079 21575865 9398855
EIF3L RPS16 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
RPL8 RPS2 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
EIF2S2 RPS18 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
EIF3L RPS9 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
EIF2S2 RPS3A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
EIF2S2 RPS6 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
EIF2S2 RPS15 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIBCH SOD2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HSP90B1 PRKCSH â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ATM ANXA2 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
EIF2S2 RPS5 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
SSRP1 SUPT6H â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
RNF168 UBB â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS27A TP53BP1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS18 RPS3 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
HNRNPAB HNRNPD â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
H2AX XRCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15613478 33961781 23145133 20224553 28514442 18406329
BRCA1 TOP2A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25184681 15965487
CALM1 ESR1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
ESR1 NONO â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33731348 25604459 31527615 20348541
SUPT16H SSRP1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 5218941 16902406
RPS3A RPS6 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
RPS3 RPS3A â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
MATR3 NONO â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
UBB UIMC1 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
BRCA1 WRN â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
FANCD2 UBB â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
H2AX PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15613478 26095369 14627815 18406329 22184063 20085707 20356835
ATM PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10464290 10608806
BAZ1B ESR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12837248 31527615
PIAS4 LEF1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11731474
SSRP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
PARP1 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20085707 34079125
XRCC6 SSRP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 30585729
WRN XRCC6 â—¼   PHOSPHORYLATION ✅ 0.86 0.86 mint 10783163 5212534
EIF3L RPS18 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
DNMT1 RPS27A â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
RPL8 RPS3A â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
NHEJ1 RPS27A â—¼   KO_UP_REGULATES ✅ + 0.86 0.86 PKG 28854368
ATR TP53BP1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMB3 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMB4 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
WRN MSN â—¼   KO_DOWN_REGULATES ✅ - -0.87 0.86 PKG 28854368
TERF2 H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21044950 22157895 21824286
XPC H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 28242625 19805520
WRN H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20802463 15733840
ATM H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 18344987 26095369 21704408 22451927 11893489 20081839 16858402 9488723 22184063 11571274 21676867 32518374 27918549
H2AX RAD51 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21317870 28190324 30560944 31009828 10959836 28796254 29499138
ESR1 UIMC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31527615 17311814
RNF8 HERC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22508508 20023648 22814251 26503038 25305019
SSRP1 MCM2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24981860 16902406 21055985 28514442
XPC PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125 28760956
PARP1 PIAS4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19779455 20696768
SYNCRIP YBX1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
XRCC6 XRCC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 30585729
HNRNPA1 HNRNPC â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
EIF2S2 RPS9 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF2S2 RPS28 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF2S2 RPS16 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EIF2S2 RPS10 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ATR BRCA1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RNF168 TP53BP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PDIA6 PRDX4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PRDX4 TXNDC5 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
TERF2 XRCC6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
RPS3 RPS9 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
PPM1D H2AX â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20460517 20101220 20118229
H2AX MRE11 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12419185 15201865 31501894 16377563 22157895 18583988 19234442
ATM MRE11 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10783165 15758953 10608806
ESR1 BTF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18025262 31527615
DNMT1 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 27728808 23708667 34079125
WRN PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 14596914 14734561
WRN PRKDC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10608806 11889123
RPS27A UIMC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PDCD6 PEF1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAB YWHAE â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
GINS3 GINS4 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
RPS16 RPS18 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
SUPT16H SUPT6H â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
YWHAB YWHAZ â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
EEF1B2 RPL19 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
EEF1B2 RPS3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HNRNPA1 HNRNPH3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
RPS16 RPS3 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
P4HA2 P4HB â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
RPS18 RPS3A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
EEF1B2 RPS3A â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HNRNPA1 HNRNPR â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RPS16 RPS3A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
NSD2 MDC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31248990 21293379
H2AX PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28796254 28242625 16377563 27728808 18406329 28514442 20000738 20085707 16522924
TERF2 MRE11 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18212065 22939629 10888888 19287395
MRE11 XRCC6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30585729 10508516 26344197
MDC1 ATM â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 29656893 26734725 12607005 14519663 18006705 28943310
MDC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 17525332 15569676 29656893 12607005 19766185 12611903
EEF1B2 RPS5 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
UIMC1 MDC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 24240613 21857162 29656893 22990118
UBE2N RNF8 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22589545 31048496 20023648 16215985 22814251 23255131 28244869 25909880 19549727 21706008 26285145 18678647 24732096 31792955 27909234 21911360 29523790
WRN TERF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12181313 18212065
XRCC6 TERF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10984620 26496610 21044950
RPS3A RPS9 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CALR P4HB â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EEF1B2 RPS9 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
RNF168 RPS27A â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
MDC1 TAGLN2 â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
HIBCH RPS18 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
EEF1B2 RPLP2 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
EEF1B2 RPS28 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
RPS18 RPS9 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
EEF1B2 RPS18 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
YWHAE YWHAZ â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
MDC1 H2AX â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21622030 21293379 15201865 20159462 18001825 28242625 26734725 16377563 12607005 18001824 14519663 30598506 18583988 32518374 12475977 21676867 19234442 29499138
H2AX BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18344987 12419185 26095369 20681793 19805520 18001825 31501894 26121674 10959836 12485996 18001824 19766185 11927591 34321665 29499138
H2AX PPM1D â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 20118229 071696 8288827
H2AX EYA3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 19234442 19351884 22908299
UBE2N H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17709392 18077395
MDC1 MRE11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12607003 30179224 29656893 20081839 12607005 14519663 18583988
BRCA1 MRE11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10426999 11353843 17349954 23530059 24413181 16391231 29656893 11504724 25184681 10783165
MRE11 EYA3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 19234442 19351884 22908299
RBBP8 MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17965729 21052091
ARRB2 ARRB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17353931 24069330 28514442 17620599
ATM EYA3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 19234442 19351884 22908299
ATR UIMC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18519686
MAPK9 BAZ1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19776015
RAD51 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11498787 31270457 19369211 14636569 24085845 29656893 28319063 25659039 34408138 31009828 9774970 16713569 25499220 19766185 17302439 9008167 28976962
DHX9 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12592385 9662397 26831064 16713569
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
PALB2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22331464 19369211 19268590 29656893 25016020 30337689 28319063 28089683 19553677 25652403 22193777 34408138 23585894 23038782 19584259 26649820 24085845 25184681 28398198
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
BRCA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17873885 11320250 14636569
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
PPP2CA CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8864841 20133759 11093160
DNMT1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21392518 20082704 20214950
DHX9 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20385589 17498979
EEF1B2 RPS27A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ESR1 POFUT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21689749 22226967 18414489
SMARCA4 LEF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19571879 11532957 21654818
RNF8 MDC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24240613 25512560 18001825 26734725 18001824 18006705 28943310
STK11 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20400510
XRCC1 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24778456 18971944 12897160 15555565 30260704 34079125 14500814 16713569 9584196 20302655 34111398 15044383 20303835
PARP1 PIAS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19779455 20932475
PEF1 PDCD6 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 32296183 26344197 27716508 21988832 21516116 11278427 25416956 16189514
XRCC6 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8422676 20711232 19303849 26175416 28345663 30585729 17308091 22939629 26496610 10750018 15941674 33005030 21969602 15520013 10064605 21575865 26446488
RPS10 XRCC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS2 RPS3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
RNF8 UBE2N â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
NHEJ1 YBX2 â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
PALB2 RAD51 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
UBB UBE2V2 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
RPS18 RPS2 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
ATR WRN â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMB3 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMB4 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
RPS27A UBE2V2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
PALB2 BRCA1 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 28319063
BRCA1 PALB2 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 8329239 22193777
YWHAZ YWHAE â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 20618440 7899808
RPS16 RPS2 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
BAZ1B SMARCA5 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SSRP1 SUPT16H â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
RPL26L1 RPLP2 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
H2AX SSRP1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 24981860 28514442 18406329 16522924
RPS2 RPS9 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
RPL26L1 RPS16 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
RPL26L1 RPS15 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
RPL26L1 RPS18 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
RPL26L1 RPS9 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
RPL26L1 RPS6 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
RPS16 RPS9 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
DNMT1 UBB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EEF1B2 RPL8 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RPS2 RPS3A â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
BTF3 RPL23A â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
EEF1B2 RPS2 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
DHX9 PABPC1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
EXO1 TERF2 â—¼   KO_DOWN_REGULATES ✅ - -0.94 0.93 PKG 28854368
BRCA1 PALB2 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
HSPA5 HYOU1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
RPL26L1 RPL8 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
WRN XRCC6 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
MDC1 TP53BP1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
RPS10 RPS3 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBB UBE2N â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
EXO1 ERO1A â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
NACA BTF3 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 24981860 26344197 21203952 30948508 33644029 10982809
RPS27A UBE2N â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
ATM YBX2 â—¼   KO_UP_REGULATES ✅ + 0.96 0.96 PKG 28854368
ATM ATR â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RPS10 RPS15 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RPS10 RPS28 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RPS28 RPS3 â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
H2AX MDC1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6805208 18583988
TERF2IP TERF2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8286516 21829167
GANAB PRKCSH â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
HLA-G LILRB2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
LIG3 XRCC1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
RPS27A RPS3 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
MDC1 PAK1 â—¼   KO_DOWN_REGULATES ✅ - -0.98 0.97 PKG 28854368
RPS18 RPS3 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BRCA1 RBBP8 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RPS15 RPS3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
TERF2 TERF2IP â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
GINS3 MCM2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPL8 RPS10 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPS10 RPS27A â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPS10 RPS5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPL23A RPS10 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPLP2 RPS10 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPL19 RPS10 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
RPLP2 RPS3 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
RPS10 RPS18 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
RPS10 RPS9 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
RPS10 RPS6 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
GINS2 MCM2 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPLP2 RPS27A â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPS16 RPS3 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPL23A RPS3 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
BTF3 NACA â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL8 RPS3 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL8 RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL8 RPS28 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS10 RPS16 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS15 RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS18 RPS27A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS27A RPS9 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS27A RPS28 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPS3 RPS5 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RPL19 RPS3 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS15 RPS28 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS18 RPS28 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS28 RPS3A â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPL8 RPS5 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
RPS15 RPS5 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
RPS28 RPS5 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
RPS2 RPS3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RPS3 RPS6 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RPS3 RPS3A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RPS3 RPS9 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT5 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
GINS3 GINS4 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPL19 RPS28 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS27A RPS6 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS5 RPS9 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
GINS2 GINS3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPL23A RPLP2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPLP2 RPS15 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPLP2 RPS9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPS10 RPS2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPS10 RPS3A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GINS4 MCM2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPLP2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPS27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPS15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23A RPS18 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23A RPS28 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23A RPS27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL23A RPS15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL8 RPS18 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL8 RPS15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPLP2 RPS28 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPLP2 RPS18 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPS15 RPS2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPS16 RPS27A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPS27A RPS3A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPS27A RPS5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL19 RPS18 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL23A RPS5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL8 RPLP2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS16 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP2 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS16 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS9 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS15 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS16 RPS28 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS16 RPS18 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS18 RPS9 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS18 RPS2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS18 RPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS18 RPS5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS18 RPS3A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS2 RPS27A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS2 RPS28 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS28 RPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPS28 RPS9 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL19 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPL23A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPL8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS9 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS16 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL19 RPS5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23A RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23A RPS16 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23A RPL8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23A RPS3A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL23A RPS9 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS3A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS16 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL8 RPS9 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS15 RPS18 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS16 RPS5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS16 RPS9 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS16 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS2 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS3A RPS5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS3A RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPS5 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
UBE2N UBE2V2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
GINS2 GINS4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMB3 PSMB4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPL19 RPS2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPL19 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPL23A RPS2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS16 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS16 RPS2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS2 RPS5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS2 RPS9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS2 RPS3A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS3A RPS9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS6 RPS9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SSRP1 SUPT16H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NSD2 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
NSD2 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
XRCC6 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H2AX UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
H2AX ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
ATR H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 20461094 20976184 20471486 22224778 17303408 28797244 18677104 19622404 15798197 19793801 9488723 20860841 12919958 18158901 20165693 20936109 22002605 26114388 29114052 21283714 22819196 19282663 24893124 17116885 22531632 17582221 30013081 25438756 26019182 17384638 19647519 20205745 23166506 25852739 18471973 27442013 22247744 29584802 20542002 19875294 25249630 20368801 15459660 27332952 27715493 19772495 25247188 17296725 11877377 14643438 24813610 20613862 17102137 20847938 21148072 23443128 27431324 29163782 23754961 17690115 15975956 18663141 21787120 22545090 27077811 19781914 27164092
MAPK9 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16818236 19234442 18158901
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
BAZ1B H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22971774 27449264 26941327 20823147 20965415 19092802 19707781 21326359 25979708 31151422 30013081 19234442 26628370 27220480
EYA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20965415 19351884 19234442 30013081
MAPK8 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22972376 16818236 19234442 17211821
EYA3 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20965415 19351884 19234442
PRKDC H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 107.0 1.0 Omnipath 18454178 9488723 19321613 21930799 19305155 25487737 22819196 20493860 17570479 12607005 16673875 26976643 17723002 21151168 16039583 21514376 26438602 19049966 20368801 23916969 16935931 27919340 17923115 16061642 18438399 20157519 20461094 21690091 24253929 19531483 26960975 25168287 18758438 19268590 27813335 25690891 17210576 26748709 18406329 23972723 17412408 34429760 27551505 12692309 29221122 20703100 16861886 25070753 27332952 33691101 33863809 23653357 21283714 16788066 19781914 20205745 20860841 21389100 16148027 20116089 15610743 20192759 20224553 14627815 24893124 10734083 20488183 23185622 18157161 33945602 30573684 12766154 25699710 18755145 27738310 10477747 34504648 16820894 20356835 19014481 20713529 17525342 23671119 26114388 23355489 28790110 23678292 20118229 23166506 33986864 15604242 16377563 20609246 12907603 26119999 25072018 15289343 23891091 25269479 23620287 33731502 22972376 34282773 26578593
ATM H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 197.0 1.0 Omnipath 27410735 28544233 16426903 28797244 9488723 23847653 30197789 21930799 18158901 21693595 18848500 22819196 15603757 16760673 17570479 24688021 24793032 27458206 16531125 22028490 30154456 19230794 23202908 25852739 19059218 26073471 22247744 28259974 29584802 25691887 19049966 20368801 26700820 29386061 28124509 20613862 27550454 20847938 27388041 27752097 23269287 24480460 22237206 20461094 20971043 26941327 18285803 21690091 15279774 23891287 25847270 24490130 25349305 26906421 20637859 26314960 15286739 27780918 20454618 30013081 28671946 25218945 23742011 26391293 23972723 23382699 26416514 27442013 20703100 24726884 26512707 27332952 29641431 25287622 26295265 14643438 29163809 25264544 19895790 26504743 26113859 27431324 28790385 18413980 21283714 21787120 20205745 19781914 25093845 27135971 23227178 22224778 20923785 20860841 24244154 23386996 30065307 16858402 11879731 28009280 23343929 20192759 22761798 26855420 24378750 20068231 20580718 14504478 24893124 29048667 25661368 26860083 26019182 20488183 28764946 22205726 23977391 18471973 19591958 28239143 20542002 17525332 20495376 18755145 23050241 17782711 11571274 19473884 28431265 25742493 18248856 17690115 20684759 26317467 21727091 24651472 25827888 27164092 28587922 20976184 30723510 20471486 23772364 29794999 11893489 19014481 20165693 26671524 16997395 20936109 26114388 23845989 15138496 22761813 23355489 27455285 28943310 21348461 19647519 23678292 23166506 28099474 29434792 25249630 25269479 27310012 15177039 22559321 26045162 20865059 22972376 21148072 26760771 21188122 22962268 22768044 26711340 20460517 27845910 28855246
PPM1D H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20118229 20101220 20460517
RNF8 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19772495 7575488 18590585 17303408 18001824 18678890 18583988 18001825 18678709 12607003 9407949 17660363 18006705 15279786 15459660
RNF168 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19342239 22980979 31533041 18443409
H2AX TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 20075863 18001824 21317870 12447390 17024177 18001825 21566653 12607005 12697768 21623170
H2AX MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21676867 14519663 18001824 21293379 16427009 16377563 18583988 21622030 18001825 12607005 19234442 20159462 15201865
XRCC6 MRE11 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MRE11 WRN â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
MRE11 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
MRE11 EXO1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19709933 26240375 17570479 31353207 10608806
PRKDC H1-2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18250087 28392790 22249259 31032946
PPP2CA ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
PPP2CA ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
WRN ATM â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM MDC1 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
ATM UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
WRN ATM â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
ATM MDC1 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
ATM MDC1 â—¼   ENZYMATIC_REACTION ✅ 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM FANCD2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM EXO1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM PARP1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM STK11 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11331603 11571274 11877377 12234250 12607003 15140942 15459660 15964794 16163361 17303408 18001824 18006705 20160076 23030059 23847781 9488723
ATM MDC1 â—¼   REGULATES ✅ 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
ATR ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15510216 10608806 17478428 17124492
PPP2CA ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15510216
PPM1D ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15510216 19360021 16949371
ATM TDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26421495 29216365 24947324 29078113 19851285 34181949 24493735 29718323
ATM TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 25128619 22496453 34194047 30323812 26158765 16862143 28607002 19584288 20858735 28851455 18285803 34419074 17833484 22491012 25404613 21642969 28439615 27364555 27602502 26671524 23096706 23935532 28739276 24754998 25905708 28847822 24461736 23318425 23346550 17178852 27432546 27820601 17942393 21868291 32060145 22205726 25846574 26293668 25533843 23034801 23352131 28249048 23633913 17525332 18657500 24794298 23645696 26212333 23050241 22715096 27376578 23370278 24657165 29540829 25173936 19071136 28847828 20424263 34518220 25956864 23554604
ATM NABP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25249620 26170237 28448822 21051358 18449195 23178594
ATM MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 28193847 21705321 22234877 12607003 12607005 22234878 17525332 18006705
ATM FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 16280053 17303408 15057286 12427531 15607958 25891850 16163361 21466974 20068231 14499622 17570479 12086603 19774700 23847781 14599770 15964794 22057367 28825622 12607003 17525332 15459660 16943440 15979372 11877377 27094386 15279770 28552166 12612651 19101576
ATM TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16223874 17525332 15314656
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
ATM EXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 15964794 11877377 17303408 18756267 16163361 15867354 23847781 23675572 25956864 26240375 11438669 24705021 12607003 18048416 17525332 20019063 15459660
ATM RNF20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21763684 21362549 26184323 17525332
ATM PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17189255 12231622 17303408 24492479 10464290 22230547 15677476 16822724 28985363 29088817 16163361 32868446 19549901 25818648 22923485 19103741 17570479 27939942 19808981 23847781 22355272 24714417 15964794 21376743 31983282 25224041 16908529 12607003 19244120 17525332 15459660 34249431 28107384 12186630 25714019 11877377 26553138 27568553 19535303 15507430 26578593
ATM RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 23468639 23675572 17570479 24837676 10910365 16249056 11689934 10608806 17525332 22743550
ATM STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 11853558 25329316 12234250 12805220 18971907 20864035 29284117 21191146 17570479 20160076 25488815 25244018
ATR FANCD2 â—¼   PHYSICAL_INTERACTION 58.0 1.0 ACSN 11438669 11850621 11877377 12086603 12607003 14988723 15136767 15175241 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18087292 18469862 18511906 18543256 18584027 18677104 18716619 18756267 18809224 18931676 18995830 19004803 19282663 19342888 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 20723763 21376743 22743550 22751496 23444773 24050180 9488723 9858600
ATR MCM2 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR FANCD2 â—¼   SHARES_COMPLEX 58.0 1.0 ACSN 11438669 11850621 11877377 12086603 12607003 14988723 15136767 15175241 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18087292 18469862 18511906 18543256 18584027 18677104 18716619 18756267 18809224 18931676 18995830 19004803 19282663 19342888 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 20723763 21376743 22743550 22751496 23444773 24050180 9488723 9858600
ATR PARP1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR BRCA1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR FANCD2 â—¼   ENZYMATIC_REACTION ✅ 58.0 1.0 ACSN 11438669 11850621 11877377 12086603 12607003 14988723 15136767 15175241 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18087292 18469862 18511906 18543256 18584027 18677104 18716619 18756267 18809224 18931676 18995830 19004803 19282663 19342888 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 20723763 21376743 22743550 22751496 23444773 24050180 9488723 9858600
ATR EXO1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR MCM2 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR MCM2 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR MCM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 18309293 22179839 18691976 15448142 16899510 30062004 19690332 18077418 16446360 24685613 15210935 17525332
ATR FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 27713304 16943440 27094386 22057367 15616588 18077418 18082599 14988723 19101576
ATR BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 26927092 17478428 24746700 15159397 17531442 10866324 18677104 19622404 15798197 19793801 20860841 16713569 11114888 23422745 20936109 16322207 19282663 20068231 17116885 17582221 25879655 10608806 17384638 23346553 12773400 12183412 17525332 15459660 11278964 17296725 11877377 17102137 10550055 16522651
ATR RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18677104 19622404 15798197 19793801 15485915 24842372 20051983 19282663 17116885 17582221 17384638 23273981 18511906 18716619 19490890 15459660 30135856 19357644 17296725 11877377 17102137 25956864
ATR PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12186630 22592045 22057367 24500207 18077418 16908529 15507430 29309644
ATR EXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 18677104 19622404 15798197 19793801 11438669 18756267 19282663 17116885 17582221 17384638 17525332 20019063 15459660 17296725 11877377 15867354 17102137 24705021 18048416
ATR POLH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21242293 26988343
ATR TDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18077418 20009512
BRCA1 UIMC1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 FANCD2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 UIMC1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 FANCD2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
BRCA1 XPC â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
BRCA1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16940443 19445691 22787115 21087664
UIMC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17525341 17525342 17525340 17621610
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
BRCA1 FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12887909 12485996 11239454 25652403 14499622 16713569
BRCA1 PALB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26649820 19268590 28089683 28319063 19369211
BRCA1 RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 21908405 18285836 16713569 15485915 25310973 9738006 17525342 17525340 16843262 24085845 25184681 26387952 18369654 9811458 16818604 20351172 23416467 19442256 10196224 10910365 19452558 11739404 25252691 10764811 25659039 17965729 11689934
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
CLU LRP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 32332780 17260971 7768901 16713569
ESR1 CTSD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7786196 19383337 19569049 16219765 8524236 9731700 11165043 18414489 2350335 10037443 8195246
ESR1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19462000 20351196 19605792 11973645 16885386 19282383 19250199 12839940
SNAI1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11850205 16766568 15955695 11245431
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
SSRP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15171726 23810005 1406642 19946334
ESR1 MACROD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17893710 18206366 19403568 15691879
PAK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18521086 26944939 16778166 18755239 21893191 15178330 19205871 29548483 26554417 27003261 24505617 16452229 15193262 19557173 15642175 12374744 19465939 17604944 25447917 20179234
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
TP53BP1 EXO1 â—¼   REGULATES ✅ 21.0 1.0 ACSN 11042216 11438669 11877378 15496928 15549137 15655342 15867354 17243194 18001825 18048416 18171670 18212739 18756267 19217833 19270065 19490890 20019063 20021983 20064462 20646866 9748285
FANCD2 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCD2 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
GINS3 GINS2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
GINS3 GINS2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
GINS4 GINS2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
GINS4 GINS2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
GINS4 GINS3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
GINS4 GINS3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 16531994 17102137 17116885 17296725 17417653 17582221 17652513 18451105 19158510 19223333 19793801
KDM4A HERC2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4B HERC2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
HERC2 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
HERC2 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
HERC2 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20023648
HERC2 RNF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20023648 22508508 25305019 22814251
HLA-G LILRB1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10591185 11513144 11994457 15771571 16287995 9933109
HLA-G LILRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12853576 17056715 19841038 19583775 12874224 28484462 16455647 16189514 15718280 9933109
HMGA2 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
HMGA2 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
HMGA2 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
KDM4A UBE2N â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4A PIAS4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4A UBE2V2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
RNF8 KDM4B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4B PIAS4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4B UBE2N â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4B RNF168 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
KDM4B UBE2V2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19203579 22589545 22980979 18001825 19203578 18001824 18006705
PIAS4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11731474
WRN LIG3 â—¼   PHYSICAL_INTERACTION 38.0 1.0 ACSN 11283614 11900249 12202749 12648680 14726013 15385537 15703371 16449207 16697054 17055429 17116323 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19362533 19490890 19809470 19847258 20027199 20056333 20064462 20211143 20691907 20713526 21376743 2191300 22657828 22743550 23082994 23161013 23253856 24036544 24050180 24709898
XRCC1 LIG3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
PARP1 LIG3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
PARP1 LIG3 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
LIG3 XRCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 9705932 20227374 17353931 11163244 26496610 16713569 8264637 11352725 9136882
PRKDC MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11749722 16319174
MAPK8 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 7890696 15696159 15071501
MAPK8 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 18985696 25862939 15696159 11956222 19788416 21081103 15071501 18559254 7890696
MAPK9 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17570479 15071501
XRCC6 MDC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MDC1 RNF8 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 RNF8 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 TP53BP1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
MDC1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16009723 17145710 18087291 17925396 12607005
MDC1 RNF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 24240613 18001824 25512560 18001825 18678647 18082599 18006705
PRKDC NHEJ1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 16439204 17470781 22529269 15451442 14561766 12077346 10757784 9259561 16439205 11702069 18046455 9430729 12509254
XRCC6 NHEJ1 â—¼   PHYSICAL_INTERACTION 13.0 1.0 Reactome 16439204 17470781 22529269 15451442 14561766 12077346 10757784 9259561 16439205 11702069 18046455 9430729 12509254
P4HA2 P4HB â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 4.0 1.0 Reactome 2543975 16591531 1323838 14500733
PPP2CA PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9873003 18586681 10322434
PAK1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19379710 22595609 24556840 25084828 26004407 19923321 25472536 15833848 28423359 24168186
PALB2 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19423707 20871616 24141787
PARP1 XRCC1 â—¼   PHYSICAL_INTERACTION 70.0 1.0 ACSN 10858306 11163244 11283614 11900249 11948190 12032095 12202749 12637553 12648680 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19748837 19809470 19847258 20027199 20056333 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 WRN â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15211575 15385537 15385968 15498778 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19654615 19748837 19847258 19892829 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24089143 24095737 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 RBBP8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
PARP1 XRCC1 â—¼   SHARES_COMPLEX 70.0 1.0 ACSN 10858306 11163244 11283614 11900249 11948190 12032095 12202749 12637553 12648680 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19748837 19809470 19847258 20027199 20056333 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 WRN â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15211575 15385537 15385968 15498778 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19654615 19748837 19847258 19892829 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24089143 24095737 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 SNAI1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 14726013 15211575 15498778 15703371 16697054 17088286 17116881 17965729 18584027 18809224 19208614 19362533 19364882 19654615 19847258 19892829 20064462 20603072 21270334 21376743 21577210 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24089143 24095737 24210699 24684389 24976506
PARP1 WRN â—¼   ENZYMATIC_REACTION ✅ 71.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15211575 15385537 15385968 15498778 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19654615 19748837 19847258 19892829 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24089143 24095737 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 XRCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9592149 18971944 15555565 19643912 15044383 14500814 16713569 24778456 12897160 20303835 20302655 9584196
PARP1 SUPT16H â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18406329 16682447
PARP1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17088286 20603072 21577210 15703371 24050180 19208614 19364882 22469522 22713970 23562323 14726013 21376743 21270334 19847258 23568489 23145148 22055391 22921416 24210699 16697054 22743550
PIAS4 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
PPP2CA PRKCB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15880462 8749392
PRKCB TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19007248 12569090 19691289 17081983 8939955 96081879 18691976 9804834 7499337 11940573 15212693
PRKDC TDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 26421495 29216365 29078113 19851285 20009512 24493735 29718323
PRKDC WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 29043077 11889123 17570479 20516064 24429382 18157161
PRKDC TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19444312 27432546 23370278
WRN RBBP8 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
XRCC6 RNF168 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
RNF168 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
RNF8 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
RNF8 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
RNF8 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18001824 18006705 19203579 19772495
RNF8 UBE2N â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20023648 21911360 22589545 25909880 16215985 24732096 18678647 26285145 23255131 22814251 19549727
XPC SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19740755
SMARCA4 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19740755
WRN TERF2 â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
TERF2 TERF2IP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 17145710 19651898 15316005 27214791 10888888 21217703 19287395 15383534 26496610 23086976 19164295 15100233 16880378 26450775 21829167 10850490 28082411 23307557 21044950 14565979
TERF2 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 15665826 18212065 12181313
XRCC6 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53BP1 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
UBE2N TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 17349954 17652783 18196958 19203579 19258535 19793861 19793862 19841479 19851286 22771115
TP53BP1 UIMC1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
XRCC6 UBE2N â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
UBE2N UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
XRCC6 UBE2V2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
UBE2V2 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
WRN XRCC1 â—¼   PHYSICAL_INTERACTION 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
WRN XRCC1 â—¼   SHARES_COMPLEX 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
YWHAE YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178
YWHAB YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178
YWHAZ YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21988832 20936779 20618440 26496610 16376338 17979178 19766566
YWHAE YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21988832 20936779 20618440 26496610 16376338 17979178 19766566
MDC1 MACROD1 â—¼   KO_DOWN_REGULATES ✅ - -1.03 1.02 PKG 28854368
MDC1 TERF2 â—¼   KO_DOWN_REGULATES ✅ - -1.08 1.07 PKG 28854368
NHEJ1 TERF2 â—¼   KO_DOWN_REGULATES ✅ - -1.08 1.07 PKG 28854368
MDC1 ANXA2 â—¼   KO_UP_REGULATES ✅ + 1.09 1.09 PKG 28854368
EXO1 PRDX3 â—¼   KO_DOWN_REGULATES ✅ - -1.45 1.44 PKG 28854368
PRKDC ATM â—¼   KO_DOWN_REGULATES ✅ - -1.5 1.49 PKG 28854368
WRN MACROD1 â—¼   KO_DOWN_REGULATES ✅ - -1.57 1.56 PKG 28854368
NHEJ1 MACROD1 â—¼   KO_DOWN_REGULATES ✅ - -1.59 1.58 PKG 28854368
EXO1 MACROD1 â—¼   KO_DOWN_REGULATES ✅ - -2.22 2.21 PKG 28854368
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
WRN WRN â—¼   KO_DOWN_REGULATES ✅ - -3.6 3.59 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
NHEJ1 NHEJ1 â—¼   KO_DOWN_REGULATES ✅ - -6.47 6.46 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368