Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ATM H2AX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1106300109 22451927
ATM H2AX â—¼   COLOCALIZATION 2.0 0.8 intact 16858402 5218840
HMGN1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19079244
MCPH1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16217032
ESR1 BLM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17268063
KPNA2 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9497340 6547667
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
MCPH1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15220350
CDK9 CDC37 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
CSNK2A2 SET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23374587
HSP90AA1 DNAJA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
NBN EP300 â—¼   COLOCALIZATION 2.0 0.8 intact 21108945 8058069
EP300 CCNT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 7265510 19387490
EP300 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20428248
EP300 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20488183
WDR4 FEN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1002349 26751069
POLD1 FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
FEN1 MUS81 â—¼   COLOCALIZATION 2.0 0.8 intact 22551069 8372920
ORC3 MCM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
MCM7 ORC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
MYH10 TDRD6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NSMCE2 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NSMCE2 TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NUMA1 MACF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NUMA1 TLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TOP3A PML â—¼   COLOCALIZATION 2.0 0.8 intact 6743819 18418389
SLTM REV3L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HMGN3 STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TOP3A TERF2 â—¼   COLOCALIZATION 2.0 0.8 intact 6743819 18418389
TERF2 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 21824286 8202878
XRCC6 TNKS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
XRCC6 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
H2AX GPATCH8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ATN1 WDR5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
WDR5 CHD8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7542690 20085832
TEP1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SIAH1 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
PFKL ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
TRIP6 ATN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SF3B4 SRSF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
CSNK2B SET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23374587
TERF1 ORC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16799465 5218770
ORC2 ORC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
TBPL1 POT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23342266 21423278
TERF2 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
ATG5 UCHL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TERF1 TNKS â—¼   COLOCALIZATION 2.0 0.8 intact 7987670 20696165
MECP2 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LLGL1 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NCL FBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18292223 0712387105
ESR1 GTF2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17495528 14675539
ESR1 GTF2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17495528 14675539
ESR1 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16511840 23038705
MECP2 CYFIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90B1 MYO10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HMGN2 RPS8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SF3B2 DMD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SNRNP70 PRMT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PRMT5 CLK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
ORC3 ORC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
ACTN1 LPP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12615977
TERF1 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
TBPL1 TERF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23342266 15380063
ASS1 AKTIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HMGN2 SYNE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HMGN2 UTRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
APEX1 EP300 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
ATM WRN â—¼   PHOSPHORYLATION 0.8 0.8 Signor 10608806
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
DDB1 MUS81 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 27354282 24412650
H2AX MRE11 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 6805208 18583988
MRE11 H2AX â—¼   COLOCALIZATION ✅ 0.81 0.81 mint 22157895 8303386
LYAR RPS6 â—¼   PHYSICAL_INTERACTION 809.0 0.81 STRING 36370105
TBPL1 GTF2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24835508
SF3B4 SNRNP70 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
ESR1 APEX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
XRCC6 APEX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 30585729
BRCA1 APEX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 26831064
BAG3 MCM7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22863883 23824909
MECP2 BLM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ORC2 BRCA1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17525332 25184681
BRCA1 CENPF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26831064 29656893
CDK9 DDX21 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26209609 25470060
DDX21 DKC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25470060
EP300 PRDX4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
MRE11 NBN â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
MECP2 TOP3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
XRCC6 BARD1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15782130 22990118
SRRM2 SF3B4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16159877 22939629
LYAR DKC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 33961781
HEXA TERF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ARL4D TERF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ARL4C TERF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MECP2 DDX24 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ESR1 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20308691 21182205 19805454 20348541
ESR1 RBM33 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
ESR1 PRDX3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 25604459
ESR1 SYNE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
PLOD1 PLOD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DNAJA2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
ESR1 STUB1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
SRRM2 ZC3H18 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
BAG3 SF3B4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 25416956 23824909
BRCA1 TERF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 19797051 29656893
BRCA1 TERF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 25184681 19797051 29656893
BRCA1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
PCBP1 CDC37 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WDR5 DDB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31155351 33022573 17041588
LARP7 DDX21 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26725010 29845934 33961781 25470060
BARD1 LARP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 32726637
H2AX PPM1G â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 18406329 24981860
XRCC6 ORC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15910003 31160578 30585729
RING1 WDR5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22325352 24981860 33022573 27705803
ESR1 LYAR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21182205 33731348 31527615
ESR1 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 21182205 19805454 31527615
FBL RPS8 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
ATM NBN â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10802669
DNAJA2 HSPA4 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FEN1 WRN â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BLM H2AX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15364958 29523790
EP300 XRCC6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15023334 33742100 21988832
BARD1 H2AX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12485996 11927591
CLK3 USP9X â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 23602568
ESR1 SET â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31527615 20348541
SF3B2 SNRNP70 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
RNF113A SRRM2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SET APEX1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12524539 12628186 16189514
BLM TOP3A â—¼   COLOCALIZATION ✅ 0.85 0.85 mint 20711169 8048867
BRCA1 WRN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16714450 24709898 29656893
CDK9 CCNT2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
DKC1 TERT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19179534 18358808 23474713
TEP1 TERT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 9837921 11029039 9389643
H2AX XRCC6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 23145133 15613478 33961781 18406329 20224553
ESR1 MYH9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21182205 19805454 25604459
MCPH1 TERF2 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
BAG3 SF3B4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
BRCA1 WRN â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
NBN BLM â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 29523790 10783165
LYAR DDX21 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 33961781
H2AX NBN â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6805208 18583988
H2AX NBN â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22565321 8391733
NBN H2AX â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22157895 8303386
ESR1 TAF2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9765300 31527615
WRN XRCC6 â—¼   PHOSPHORYLATION ✅ 0.86 0.86 mint 10783163 5212534
ACD TERF2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15231715 16880378 15383534
ESR1 CCNT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15940264 31527615
ERCC4 MUS81 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CHD8 WDR5 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ATM H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16858402 27918549 22184063 9488723 32518374 20081839 18344987 21676867 22451927 21704408 11571274 11893489 26095369
CARM1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16923966 18280497 11997499 21988832 11701890 32140074 28844863 15731352
LARP7 CCNT1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18281698 26725010 33961781 27684187 18483487 24367103 29845934
PPM1G XRCC6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 30585729 28330616
WRN H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20802463 15733840
TERF2 H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21824286 21044950 22157895
PIAS1 ESR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11117529 15666801 31527615
ERCC4 FEN1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GTF2A2 TBPL1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
RNF113A SF3B4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
POT1 TERF1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
FBL RPS6 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ACD TERF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BLM FEN1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CDK9 HEXIM2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ATN1 BAG3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
SF3B2 SRRM2 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CCNT1 LARP7 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
TERF2 XRCC6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
FEN1 APEX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11601988
ATM MRE11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10608806 10783165 15758953
MRE11 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29523790 28506294 10783165
BRCA1 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25084169 10783165 26831064 29656893
CDK9 CDC37 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32707033 25036637 24189400 33961781 20305087 26186194 24981860 27684187 23455922
CDC37 CLK3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32707033 33961781 24189400
NBN EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21108945 16051665
XRCC6 SET â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863883 27626385 30585729
H2AX MRE11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16377563 19234442 31501894 22157895 15201865 12419185 18583988
SF3B4 SF3B2 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22365833 8293266
SIAH1 PIAS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17533377 27485016
CLK3 SRRM2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32707033 33961781 23602568
CHD7 CHD8 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20453063 24705355
ACD TERF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 15383534 15231715 16880378 26496610 33961781 26186194
ATM BLM â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PML RNF4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
KIAA1429 ZC3H13 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CDK9 LARP7 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
SF3B4 SRRM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ESR1 HSPA4 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HSP90AA1 TERT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CARM1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
BLM FEN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14688284 16326861
NBN BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10426999 18171670 19244116 12124328 10783165 25659039 25184681 25939603 11504724 29656893
MYH9 MYH10 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 16596254 26496610 24981860
TERF2 NBN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 19287395 10888888
CCNT1 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28555140 12727882
RNF4 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29180619 19380586 24907272 15707587 23028697 18408734 21252943 18708055 24637324 22388745
WRN TERF2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12181313 18212065
MRE11 XRCC6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 30585729 10508516 26344197
XRCC6 TERF2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21044950 26496610 10984620
TERF2 MRE11 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 19287395 10888888 18212065
ATN1 WDR5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16713569 27705803 33961781 24981860 26186194
TERF2 ORC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16799465 18761675
TERF1 TNKS â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
EP300 APEX1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14633989 20856196 20808282 30110629 19934257
TERF1 ATM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18160036 11375976 15314656
ATM BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 29656893 10783165 11016625 10866324 10550055 15713674 18344987 10608806 17478428
ATM NBN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24800743 10783165 25088203 11252893 30952868 10608806 17507690 22464731 25895060 10839545 15758953 10839544
ATM BLM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29523790 10783165 12034743
ATM RNF40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21763684 26184323 17478428
BLM TOP3A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12724401 20360068 11406610 23509288 24239288 10734115 26496610 30279242 11470874 15775963 10825162 20711169
BLM TERF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12181313 19329795 15229185
H2AX BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12485996 34321665 19766185 18001824 31501894 11927591 18344987 20681793 26095369 18001825 29499138 19805520 26121674 10959836 12419185
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
BRCA1 MRE11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10426999 10783165 17349954 25184681 23530059 16391231 11353843 24413181 11504724 29656893
CDK9 LARP7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26659056 32707033 17643375 20562857 18281698 26725010 33961781 26186194 23602568 27684187 23455922 18483487 24367103 29845934
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
EP300 FEN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11430825 20019387 16326861
EP300 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10801418 15342649
WRN FEN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16326861 12356323 11598021 14657243 14688284
NBN H2AX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11110662 18583988 15733840 16377563 31501894 20081839 23145133 22157895 22941933 21676867 16932743 15201865 18001825 18001824 12419185
NBN MRE11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 30179224 11238951 17612497 22941933 23530059 15758953 11062235 10426999 19244116 10783165 18458108 21884979 22464731 33558481 24413181 26455393 12447395 12679336 28369484 22078559 34038735 22231403 12419185 22939629 34348893 17526493 12861053 17500065 12750284 9705271 28363998 30440001 24981860 19270065 12607003 15734743
TCOF1 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25064736
NSMCE2 SMC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055714 18086888
WRN XRCC6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 12177300 11328876 26496610 14734561 33961781 10880505 10783163 30585729
H2AX MCPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17599047 22154951
ESR1 BARD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17275994
WDR5 CHD8 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15960975 20085832 24705355 18378692
RPL13 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TERF2 ORC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16799465 31160578 18761675
MECP2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21655924 23242655 15870696
ESR1 CLASRP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 HMGN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8700510 17938209 18414489
ORC3 ORC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15232106 16549788 26496610 14681455 31160578 22398447 17716973
SET MCPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18718915 21515671 21911480
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 HSPA4 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CDC37 CDK9 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
LARP7 CDK9 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 6613869 18483487
ORC2 MCM7 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 12614612 20808282 16189514
ORC3 MCM7 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 12614612 15232106
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
ATM NBN â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
BAG3 HSPA4 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
HSP90AA1 STUB1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
CSNK2A2 CSNK2B â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
KPNB1 KPNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17596301
DKC1 FBL â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
BLM MUS81 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ORC1 ORC6 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
TOP3A WRN â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
WRN XRCC6 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
RNF113A SF3B2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
BLM TP53BP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
FEN1 POLD1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ORC6 ORC2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15910003 28514442 11323433 12614612 16549788 33961781 26186194 12004060
MCM7 ORC3 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
BARD1 BRCA1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12431996 17525341 29367421 27977889 19916563 12732733 10477523 20060929 23680151 8944023 22110403 12951069 23086937 14638690 27239795 29355525 9788437 11925436 11257228 24289923 14647430 19176389 15184379 9738006 16403807 29180510 11278247 33589814 15265711 15159397 34408138 16713569 19117993 20681793 16391231 11301010 16489000 23416467 17664283 15569676 29858377 19369211 18493658 29656893 20351172 28398198 12485996 32347575 19766185 14636569 10026184 12700228 31270457 11573085 11526114 24085845 25823446 33961781 32092106 18936166 28514442 20215511 25184681 26490435 28948225 12890688 12438698 28262780 26831064 9342365 10635334 15855157 11504724 11773071 25252691 9798686 26350354 21901007 24695549 12887909 17873885 11498787 27454289 11927591 24981860 25652403 25634209
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CDK9 CCNT2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 9499409 16331689 18566585 17643375 10465067 33961781 24981860 21729782 26186194 23602568 11282025 27684187 23455922 11713533 26344197
ORC6 ORC3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 15910003 12614612 11323433 17716973
SMC5 SMC6 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15601840 26496610 18086888 33961781 32389690 11408570 26344197
ORC3 ORC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15910003 20850016 12614612 26496610 16549788 31160578 11395502 17525332 10402192 11323433 12004060 22939629 17716973 26344197
ORC1 ORC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16189514 20850016 12614612 11931757 26496610 16549788 14681455 22398447 31160578 11323433 11779870 17716973
GTF2A1 TBPL1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
NBN TERF2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MCM7 ORC2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MCM7 ORC1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
SF3B4 SF3B2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 32296183 16189514 25416956 25737013 22365833 7958871 24981860 16923959 10490618 22939629
NSMCE2 SMC6 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
NSMCE2 SMC5 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SMC5 SMC6 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
KPNA2 KPNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ORC3 ORC6 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ORC2 ORC6 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCNT2 CDK9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
HSPA4 STUB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GTF2A1 GTF2A2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B2 SF3B4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ORC2 ORC3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ACD POT1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL13 RPS8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL13 RPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ORC1 ORC3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
BARD1 BRCA1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ORC1 ORC2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS6 RPS8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APEX1 POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
FEN1 APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11601988 16189514
EP300 APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14633989 20856196 20711647
WRN ATM â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H2AX ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
WRN ATM â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM SMC3 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM TERF1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11331603 11877377 12607003 15140942 15459660 15964794 16163361 17303408 22266654 22634377 23847781
ATM TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16223874 17525332 15314656
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 12433983 12861053 17485521 23146902 10839545 19413330 15302935 27602502 17429352 19523210 24360018 20068231 17507690 17570479 10608806 12598907 18669648 25088203 18003706 11252893 17431132 23097684 10766245 12814430 10802669 21664921 26512707 10839544 11927276 21130714 17525332 12447395 14707289 15733840 15279770 25119968 18644472 28822740
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16199871 11146546 25766002 17984114 14643436 20719863 17363339 14729972 18054789 12034743 30496191 16880735 11375976
ATM SIAH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 27689990 15964794 11877377 17303408 19788416 16163361 27308327 23847781 18536714 12607003 15459660
ATM PPM1G â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26324325 17525332
ATM MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19709933 26240375 17570479 31353207 10608806
ATM TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 17717821 15314656 17570479 23732473 26586433 11375976 22266654
ATM H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 197.0 1.0 Omnipath 27410735 28544233 16426903 28797244 9488723 23847653 30197789 21930799 18158901 21693595 18848500 22819196 15603757 16760673 17570479 24688021 24793032 27458206 16531125 22028490 30154456 19230794 23202908 25852739 19059218 26073471 22247744 28259974 29584802 25691887 19049966 20368801 26700820 29386061 28124509 20613862 27550454 20847938 27388041 27752097 23269287 24480460 22237206 20461094 20971043 26941327 18285803 21690091 15279774 23891287 25847270 24490130 25349305 26906421 20637859 26314960 15286739 27780918 20454618 30013081 28671946 25218945 23742011 26391293 23972723 23382699 26416514 27442013 20703100 24726884 26512707 27332952 29641431 25287622 26295265 14643438 29163809 25264544 19895790 26504743 26113859 27431324 28790385 18413980 21283714 21787120 20205745 19781914 25093845 27135971 23227178 22224778 20923785 20860841 24244154 23386996 30065307 16858402 11879731 28009280 23343929 20192759 22761798 26855420 24378750 20068231 20580718 14504478 24893124 29048667 25661368 26860083 26019182 20488183 28764946 22205726 23977391 18471973 19591958 28239143 20542002 17525332 20495376 18755145 23050241 17782711 11571274 19473884 28431265 25742493 18248856 17690115 20684759 26317467 21727091 24651472 25827888 27164092 28587922 20976184 30723510 20471486 23772364 29794999 11893489 19014481 20165693 26671524 16997395 20936109 26114388 23845989 15138496 22761813 23355489 27455285 28943310 21348461 19647519 23678292 23166506 28099474 29434792 25249630 25269479 27310012 15177039 22559321 26045162 20865059 22972376 21148072 26760771 21188122 22962268 22768044 26711340 20460517 27845910 28855246
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
ATM SMC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 22369641 18442975 15964794 11877377 17303408 16163361 23847781 17570479 12607003 20501661 19906707 17525332 15459660
MRE11 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM TOP3A â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12535671 12972610 15496928 15549137 15655342 16537486 16595695 16697054 18001825 18171670 18212739 18550849 18931676 19217833 19270065 19282663 19490890 19622404 19686080 19772495 19847258 19945966 20021983 20064462 20826342 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM TOP3A â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12535671 12972610 15496928 15549137 15655342 16537486 16595695 16697054 18001825 18171670 18212739 18550849 18931676 19217833 19270065 19282663 19490890 19622404 19686080 19772495 19847258 19945966 20021983 20064462 20826342 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM POT1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 23253856 24089143 24095737
BLM WRN â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
BLM TERF2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 23253856 24089143 24095737
BLM FEN1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
TERF2 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 15229185 19329795 12181313
TERF1 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 15229185
BLM FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19772495 18931676 19847258 22266823 12356323 19622404 16326861 24089143 22973052 23253856 22657828 16697054 24095737 19686080 14688284
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 BARD1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 SMC3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11877377 15459660 16697054 17102137 17116885 17296725 17582221 18451105 19158510 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 MRE11 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 SMC3 â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 11877377 15459660 16697054 17102137 17116885 17296725 17582221 18451105 19158510 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 BARD1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
BARD1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 99.0 1.0 Omnipath 16403807 16391231 28262780 15159397 25652403 26350354 26490435 14647430 11927591 25184681 16713569 11526114 35203293 9738006 12732733 24289923 11573085 18936166 23086937 24085845 12890688 15855157 24695549 19369211 9798686 11257228 11498787 12700228 11925436 10477523 19176389 23680151 25634209 23416467 34726323 29355525 18369654 14636569 11504724 12951069 19117993 20060929 17873885 14638690 18493658 11278247 15184379 22110403 11301010 11773071 12431996 10635334 20029420 9788437 17664283 21901007 25252691 12485996 10026184 12438698 17525341 16489000 8944023 15265711 12419249 20681793 9342365 27239795 20215511 25823446 19916563
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
CSNK2A2 CDC37 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20068231 15082798 19413330 12930845
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CSNK2A2 HSPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10772927 12558502
CSNK2A2 GTF2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17570479 11278496 18452278
POLD1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
CARM1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15731352 21988832 11997499 11701890 15616592 16923966 18280497
EP300 FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19608861 11430825
EP300 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20471956 16051665 21108945
EP300 HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19608861 10753971
WRN FEN1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
POLD1 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
NBN FEN1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
FEN1 MRE11 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
WRN FEN1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
WRN FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 14657243 12356323 11598021 16326861 10893179 14688284
NBN BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MRE11 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 22464731 26455393 12861053 17500065 15734743 12419185 19270065 22078559 19244116 21884979 12679336 11238951 12607003 9705271 17713585 10783165 12447395 10426999 18458108 15758953
RNF4 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23028697 18708055 15707587 24907272 18408734 21252943 22388745 24637324 19380586
SMC6 SMC5 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 15496928 15549137 15655342 16697054 18001825 18171670 18212739 19217833 19270065 19490890 19772495 19847258 20021983 20064462
SMC6 SMC5 â—¼   PROTEIN_INTERACTION 14.0 1.0 ACSN 15496928 15549137 15655342 16697054 18001825 18171670 18212739 19217833 19270065 19490890 19772495 19847258 20021983 20064462
ESR1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21411498 12122114 21693539 18519947 16690106 10805720 19360348 23409030 18754863
MRE11 TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
TOP3A BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
XRCC6 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53BP1 BARD1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
H2AX TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 20075863 18001824 21317870 12447390 17024177 18001825 21566653 12607005 12697768 21623170
MRE11 WRN â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
WRN BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
WRN TERF2 â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
WRN POT1 â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
TERF2 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 15665826 18212065 12181313
XRCC6 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 MRE11 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MRE11 BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
POT1 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TNKS POT1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17825467 21181822 21818122 22433952 22634377 9822378
TNKS TERF2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17825467 21181822 21818122 22433952 22634377 9822378
TNKS TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 23583392 12080061 20811636 26186194 11854288 11739745 22153077 10988299 15133513 20696165 22645305 26496610 11802774 9822378
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
GTF2A1 CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
GTF2A2 CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
ESR1 CARM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14631847 12498683 11010967 14675539
TBPL1 GTF2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15767669 24835508 12682363 10523649
REST UCHL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21210816 17823282
PLOD2 PLOD1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 4.0 1.0 Reactome 9582318 6809411 1577494 9054364