Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PRKAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
RNF11 PRKAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKAB2 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
GSK3B GLIS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16537363
MAPK3 EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19564905
PPP2R5E SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PPP2R5E PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PIMREG HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709227105 18757745
AP2M1 IKZF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AP2M1 IRS1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
NOLC1 APC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
COPS3 ARAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
TCOF1 ARAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CSNK2B ARAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10094392 5211308
ARAF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18039929
CRY2 ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18662546
RORB ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18454201
PER1 ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18662546
BHLHE40 ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12397359 15193144
ARNTL CRY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19106159
ARRB2 MDM2 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5214648 11588219
MDM2 BHLHE40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17347673 5219751
TP53 BHLHE40 â—¼   COLOCALIZATION 2.0 0.8 intact 17347673 5219751
RYBP BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
CBX8 BMI1 â—¼   COLOCALIZATION 2.0 0.8 intact 17332741 5219708
CREB1 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9926942 6548521
EZH2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23624935 21406404
BRCA1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12700228
CBX8 RNF2 â—¼   COLOCALIZATION 2.0 0.8 intact 17332741 5219708
TP53 CCDC106 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CCDC106 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 7680651 20159018
TFAP2A CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7739559
CCNH POLR2E â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CD81 INO80B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CSNK2A1 CDC34 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5214488 11546811
RNF7 CDC34 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10851089 16874460
PPP2R1A CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R1B CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
CREB1 CDK11A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15087126
PPP1CC CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21533037
PML CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10356361 16007146
STAT5A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15003515 21038417
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
PER2 CLOCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16474406 10531061
RNF11 COPS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CREB1 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16293792 22890843
CREB1 GCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16149046 19447893
MAPK3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
CREB1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10775268
PER1 CRY2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10790862 11165242
PER2 CRY2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10790862 11165242
NPAS2 CRY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17660446
STAT5A CSN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15534001
PER1 CSNK1E â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10790862 11165242
CSNK1E NPAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16474406 10531061
CSNK1G2 PER1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15917222
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
NFKB1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19027835
CSNK2A1 CSNK2B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TP53 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
CSNK2A2 SET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23374587
MBD4 CSNK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
CSNK2B RPS6KA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10094392 5211308
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
CSNK2B SEC63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23287549
CSNK2B SET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23374587
CSNK2B WEE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18469858
CTNNB1 CTNNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
CTNNB1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CTNNB1 IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592430 12782598
SIRT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27776347 28583374
PPP2CA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10644691 19061640
CUL3 GLIS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16740475
CUL3 TNFAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19782033 25416956
POT1 DAXX â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20211137 20651253
DAXX TRIM54 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
DAXX TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 14557665 5216762
POLR2E DYNC1H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
TP53 EIF2S2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EIF2S2 EIF3H â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
NRF1 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16230352
FGB PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
FN1 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
TP53 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15230856 8732672
TP53 GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23940366 9360971
PPP2R1B HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
NFKB1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
PPP1CA HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17008050
TP53 HMGB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547598 9472015
SRC HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16844778 0604705103
IKZF1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PPP1CC IKZF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21750978 19282287
PPP1CB IKZF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21750978 19282287
PPP1CA IKZF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21750978 19282287
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAP4K1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
TP53 MAP4K4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15958553 17113036
PML MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15273249 16189514
MINK1 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8622669 8626699
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
PPP1CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
UBE2I MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
PML MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
SSRP1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9472631 12374749
MDM2 PML â—¼   COLOCALIZATION 2.0 0.8 intact 5216620 12915590
RPS6KB1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20657550
PPP1CB MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23277204
PPP1CC MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23277204
PPP1CA MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23277204
NFKB1 NOLC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21266110
PRKCZ NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11684013 12881425
TP53 NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10698490 12700242
PRKCZ NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12893839 10764587
NKAP RBM39 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
NOLC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19541936
PER2 NPAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16474406 10531061
PER1 NPAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16474406 10531061
NPAS2 PER1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19106159
NPAS2 PER2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19106159
RNF2 PCGF6 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
SIRT1 PER2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18662546
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
SSRP1 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7808017 7967725
TP53 PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PPP2R5D PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
SRC PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
PTPN12 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
RNF11 SH3KBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF11 RYBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD9 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD9 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD9 TERF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SRC TNFAIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TCOF1 SSB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 TFAP2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18980971 16636674
TNFAIP1 TRIM54 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
UBE2I TOP2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12832072 10862613
UBE2I TRIM54 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 31391242 233395
MAPK14 MAPKAPK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 14499342
BHLHE41 CRY2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
BHLHE41 CLOCK â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CSNK2B GLIS2 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
RNPS1 SRRM1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
TP53 MME â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
COPS3 HSP90AA1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
GSK3B SMAD1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 18045539 25241761
BHLHE41 CSNK1E â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
CHEK1 RAD51 â—¼   PHOSPHORYLATION ✅ + 0.81 0.81 Signor 15665856
POLR2E PPP1CA â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
YAF2 MDM2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SRC NAP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24412244 33961781
VCAM1 AP2M1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
AUTS2 RING1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27705803 25519132
PCGF6 BMI1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12167161 24981860
BMI1 RNPS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BMI1 PCGF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22493164 24981860
CBX4 PCGF5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
CD81 SET â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32900848 23463506
VCAM1 CDK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
CLOCK NPAS2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 23555304
CSNK2B INO80B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
CTBP1 EZH2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27634302 31041561
FAF1 CUL3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28443643 18775313
DCAF7 RING1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 27705803
PML EZH2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27634302 17560333
HDAC1 RING1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26496610
RING1 PCGF5 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
VCAM1 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
CSNK2A2 YAF2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HSP90AA1 SRC â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
MAPK14 MAPKAPK2 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
BHLHE41 GSK3B â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
BHLHE41 PER2 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
CSNK2A2 RNF2 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
PPP2CA PPP2R1A â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
ARNTL PPP1CA â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
CLOCK CSNK1E â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
PER1 PER2 â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
YAF2 RYBP â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 24981860
AP2M1 CRY2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
AP2M1 APC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
AP2M1 PER1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
PCGF3 AUTS2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22325352 27705803 25519132
BRCA1 TERF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 29656893 34112789
BRCA1 TERF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 25184681 29656893 34112789
BRCA1 CDK16 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 9738006 26186194 22990118 25184681
BRCA1 CDK9 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
PCGF3 CBX4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24981860 22325352 27705803
DCAF7 PCGF5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 24981860 27705803
TULP3 MCRS1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 33187986
TULP3 PML â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 33187986
MAPK3 RPS6KA2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CSNK2A1 HDAC1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCNH CDK20 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
WEE1 CDK1 â—¼   PHOSPHORYLATION ✅ - 0.83 0.83 Signor 16096060
CDK1 WEE1 â—¼   PHOSPHORYLATION ✅ - 0.83 0.83 Signor 15070733
MDM2 TP63 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
ARRB2 SRC â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BRCA1 EZH2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 23624935 25531315
RYBP CSNK2A2 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 24981860
RAD9A HDAC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10846170 16189514
PER2 PER1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 10848614 32296183 11165242 33961781
OGT PPP1CB â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
BMI1 CBX2 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CSNK2A1 PML â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CSNK2A2 FBRSL1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
DAXX HDAC1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
CBX2 RING1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CAMKV NOLC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
CAMKV RNPS1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
SRC LYN â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22581261 32707033 18070987 9169421
RNF2 PCGF5 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
PRKCZ PRKCI â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24375676
SUPT16H SSRP1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 5218941 16902406
CTDP1 POLR2E â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CSNK2A1 SIRT1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
RPS6KA2 RPS6KA3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
CSNK1E PER1 â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 15917222
PCGF3 RING1 â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
LYN CDK1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 8910336 8051175 31980649 8626437
PER2 MDM2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 30425162 34257372 25103245
MAPK3 RPS6KA3 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CDK1 LYN â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CBX4 RNF2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
NCF1 PRKCZ â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
YAF2 DCAF7 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 27705803
AUTS2 PCGF5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CBX8 CBX4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26496610 22325352 24981860 17332741
CBX4 PCGF6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 21282530 33961781 27705803
CLK2 SRRM1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 26871637
CLK2 RNPS1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 32296183
CLK2 RBM39 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25416956 23602568 32296183
CREB1 RPS6KA5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DCAF7 PCGF3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 24981860 27705803
PCGF6 HDAC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 22325352 27705803
IKZF1 MCRS1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 32296183 33961781
MDM2 PML â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RNPS1 NKAP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 17353931
RNPS1 RBM39 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28302793 26344197 17353931
CACNA1A CALM1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CACNA1S CALM1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CBX4 CTBP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
DAXX UBE2I â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
POT1 TERF1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
APC CTNNA1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CALM1 CSNK2A1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ARNTL CSNK1E â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CDK1 EZH2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CDK9 HEXIM2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CSNK2A2 RYBP â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CSNK2A2 PCGF5 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CSNK2B PCGF5 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PTK2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
MAPK14 TP53 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
EPS8 SRC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10395945 16189514
CTBP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11751867 10196224 16713569 21102443 31636387
CBX8 PCGF5 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21282530 26496610 24981860 27705803
CBX8 PCGF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21282530 24981860 27705803
CBX8 PCGF6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24981860 21282530 27705803 28514442
CSN2 CUL3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 26976604 21145461 32047038 16045761 28514442 19295130
IKZF1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 30760870 10204490 10357820 12015313 23752268 16189514
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
DAXX MDM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PPP1CA PPP1CB â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ARRB2 MDM2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
PPP1CB PPP1CC â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSNK2A1 CSNK2A2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCGF5 RYBP â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
RING1 RNF2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCGF5 YAF2 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PCGF3 RYBP â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
AUTS2 RYBP â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
YAF2 RING1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 32296183 24981860 25416956 27684187 21516116 27705803 28514442 22325352
ARRB2 NOLC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 17353931 29999490 26399832 28514442 17620599
CREB1 ATF1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25609649 20102225 1655749 8384217
ATF1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16713569 10945975
PCGF5 AUTS2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25519132 26186194 27705803 28514442 22325352
RYBP AUTS2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25519132 26186194 27705803 28514442
HDAC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220405 21102443 16713569
CCNB1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9244350 16713569 23246971 11278247
MDM2 DAXX â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6799761 18566590
DCAF7 RYBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 24981860 34316702 27705803 28514442
DISC1 EIF3H â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17043677 31413325 12812986 90000000
HUS1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10846170 16189514
HDAC1 TOP2B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11062478 11136718
RING1 PCGF3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 32296183 24981860 27705803 22493164 22325352
RING1 PCGF6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12167161 33961781 32296183 24981860 27705803 28514442 22493164 22325352
PPP2R1B PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8392071 8286818
FBRSL1 RYBP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
GADD45GIP1 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
BMI1 RYBP â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MAPK14 RPS6KA4 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
RAD51 TP53 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HDAC1 NFKB1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DAXX TP53 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
CCNB1 CDKN1A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
GLIS2 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
INO80B ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
GSK3B MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055726 18505846
ARRB2 AP2M1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20947020 17199046 12958364
TP63 ARNTL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
ARNTL BHLHE41 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16685415 16267380 15147242
MDM2 ARRB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18544533 21389118 21081496 33649538 32828283 17984062 32450252 12538596 21988832 15878855 26545496 12488444 21466165 11588219
CLOCK BHLHE40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19032342 14672706
BHLHE41 PER1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12397359 15193144 15147242
CBX4 BMI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 22078878 24981860 19636380 20601937 18453536 26496610 17332741 9199346 21282530 34316702 27647897 24457600 27705803 12829790 22325352
RING1 BMI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22897849 19636380 27705803 34133714 9199346 34316702 16751658 29402932 22493164 22325352 16359901 15386022 32296183 9858531 24457600 25416956 16189514 20601937 19451220
CBX8 BMI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 20543829 24981860 19636380 20601937 26496610 17332741 10825164 21282530 34316702 24457600 27705803 22325352
RAD51 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11498787 31270457 19369211 14636569 24085845 29656893 28319063 25659039 34408138 31009828 9774970 16713569 25499220 19766185 17302439 9008167 28976962
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EZH2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19079346 20574448
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
CCNB1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 1836978 1384126 8428596
CDK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17477081 23526763 21840486
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
FGB CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A FAF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SIRT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23474493 15130752 21719763
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
CREB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25379405 14520699 21295542
SSRP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15557281 16410722 12374749
CREB1 NOLC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21266110
CREB1 PER1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23699513 24065704 12032351
STAT5A CSN1S1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16293640 15778982 17170087
CSNK2A1 SET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17309103 23374587
CSNK2A1 TCOF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25064736
CSNK2A1 IKZF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21750978
CSNK2A1 SEC63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23287549
CSNK2B IKZF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21750978
UBE2I CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
CTNNA1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
IKZF1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 27107012 21900206 24722188 16713569 10766745 25416956 16189514
MECOM CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11328817 11313276 16713569
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
CUL3 HDAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 15467454 15688063 17312394
MCRS1 DAXX â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22609355 32296183 11948183
RPS6KA5 EZH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TAF1D EZH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
SIRT6 FAF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TAF1D FAF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HSD17B10 FAF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FGB SRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
TP53 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8090761 10029407
FGF2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9490736 29436393 12750158
FN1 SRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
NFKB1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22223884 10649441 10867646
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RAD9A HUS1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 26088138 14624239 14681455 12628935 9872989 11907025 32296183 10777662 10852904 19464297 11994305 28514442 16189514 15314187 11340080 10359610 26186194 14611806
LYN STAT5A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9837784 22509308 8861946
TP53 MAPK14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11437382 15132979 14570892
NCF1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16778989 10400704 27558335
PPP2CA MAPK3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MAPK3 PPP1CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MAPK3 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15093545
TP63 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11714701 9405685 12374749
PPP2CA MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983168
MDM2 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20571051
NCF1 PRKCZ â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
RPS6KA2 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20385620
PML UBE2I â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
SRC PPP2CA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
SET PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9353299 21806989
SRC PPP2R1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
RPS6KB1 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18769144
CSNK2A1 OGT â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
CBX8 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CSNK2A1 SUPT16H â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CDK1 CDKN1A â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
CSNK1E PER2 â—¼   PHOSPHORYLATION ✅ - 0.9 0.9 Signor 15767683
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CSNK2A1 SSRP1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PCGF5 RING1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PCGF6 RING1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PCGF3 RNF2 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
PCGF6 RNF2 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
SSRP1 SUPT16H â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
RNF2 YAF2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
AP2M1 RALBP1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
PCGF5 RNF2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
RING1 YAF2 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
BMI1 CBX4 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
CSNK2A2 CSNK2B â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
RING1 CBX8 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24981860
RNF2 CBX8 â—¼   COLOCALIZATION ✅ 0.92 0.92 mint 5219708 17332741
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CBX4 RING1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
DAXX PML â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
CBX2 RNF2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
RAD51 UBE2I â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
PTK2 SRC â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
PPP2R1B PPP2R5E â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
RING1 RYBP â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
EZH2 HDAC1 â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
ARNTL PER2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PPP2R1B PPP2R5D â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
BMI1 CBX8 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CBX2 RYBP â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 10369680 24981860
HMGB1 TP53 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
RNF2 BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16710298 5218667
BMI1 RING1 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7998286 20601937
BMI1 CBX8 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 5219708 17332741
RYBP RNF2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24981860
CBX8 RNF2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CBX8 RING1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
CLOCK PER2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
CSNK1E PER1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
ARNTL CRY2 â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
CRY2 PER1 â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
RAD9A RAD1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11907025 25091155 33961781 25602520 10777662 16189514 15314187 26088138 10852904 11340080 10359610 11994305 11572977 26186194 12628935 14611806 28514442 9872989
RYBP RING1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 28514442 33961781 32296183 17070805 24981860 16943429 30217970 34316702 10369680 26186194 27705803 25416956 34133714 16189514 22325352
ARNTL NPAS2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
BMI1 RING1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CLOCK CRY2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CSNK2B SUPT16H â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
SLX4 TERF2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EIF2S2 EIF5 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CSNK2B CSNK2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 36833176
CRY2 PER2 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CSNK2B SSRP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
NFKB1 NFKBIA â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
MAPK14 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
HUS1 RAD9A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CSNK1E PER2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CTNNA1 CTNNB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RAD1 RAD9A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS3 COPS7A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PPP2R1A PPP2R5E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R5E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R5D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SSRP1 SUPT16H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ARNTL CLOCK â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
BMI1 RNF2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CCNB1 CDK1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CSNK2A1 CSNK2B â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RNF2 RYBP â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RPS6KB1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17053147 21233202 8250835 15905173 19339977 19720745 16286006 12713446 20647036 20832730 18423201 11108711 17052453
PRKCZ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18353303 14657655 11481324
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
MAPK14 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26822034 17726008 21303975 18451303
PPP2R5D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
GSK3B NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 26999213 12871932 11425860 24618402 18669648 17693123
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
GSK3B CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 22154077 28916781 12058028 11779850 17570479 20519948 15212693 17283049 19440234
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
GSK3B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16568235 12162494
GSK3B ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21924978 20049328
GSK3B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18045539 25241761
GSK3B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9832503 17359287
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
SRC EPS8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23626693 16189514 10395945 32641864
PPP2CA APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10698523
CSNK1E APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 25241761 11425858 17570479 24722208 15327768 11487578 17218255
APC CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525529
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
ARAF PPP1CC â—¼   DEPHOSPHORYLATION ✅ 14.0 1.0 Reactome 16294014 21779496 24211266 27264673 19684605 16041367 24347342 16630891 28666118 12932319 11756411 25907612 14530258 28289718
ARAF PPP1CB â—¼   DEPHOSPHORYLATION ✅ 14.0 1.0 Reactome 16294014 21779496 24211266 27264673 19684605 16041367 24347342 16630891 28666118 12932319 11756411 25907612 14530258 28289718
SRC ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9020159
CLOCK ARNTL â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16687287 16020918 19341811 11798163 16507766 22936566 19605937 17204240
RORB ARNTL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18418469 24737872
ARNTL PER1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 22215611 25228643 20930143 17660446 20215567 10848603 22750052 12397359 12032351 20106950 19341811 11441147 20852621 21479263 24320178 15147242 17994337
ARNTL SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24442997 19897060 25309798 24089055
ARNTL CLOCK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12691740 16980631 16687287 16020918 19341811 16507766 22936566 19605937
ARNTL BHLHE40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19032342 14672706 16267380
ARNTL PER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20576619 23620290 17660446 20215567 19168071 22750052 21960634 24051492 23469106 20852621 11441147 11798163 22039518
ARNTL CRY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17660446 22750052 16628007 20852621 14645221 11798163
CLOCK ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23555304 9989497 26164627 11439184 14701734 11018023 19922678 31515488 20551151 32296183 9576906
PER2 ARNTL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18662546 20159955
CSNK2A2 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11877451
CSNK2A1 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11877451 32863206
MAPK14 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
PPP2CA ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
CSNK2A1 ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20730097 9685505 8663317 18452278 18669648
RPS6KA4 ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23331499 8384217 18813292 18690222 8663317 20068231 11018520 11335727 9687510 20626350 11909979 9016641 12414794
RPS6KA5 ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 23331499 8384217 21109534 18813292 18690222 8663317 20068231 11018520 28032861 18988627 11335727 9687510 18794154 11909979 9016641 12414794
BHLHE40 BHLHE41 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14672706 16462771 16267380 12624110 15147242
TP53 BHLHE40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22723347 17347673
CLOCK BHLHE41 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16685415 14672706 15147242 16267380
TP53 BID â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12402042 16151013 18574470
CSNK2A1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11583622 12598529 20356928
CSNK2B BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11583622
TP53 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15240700 12402042 18431400 15024076
CSNK1E BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11583622 12598529 20356928
CSNK2A2 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11583622
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
BMI1 RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16710298 22493164 22902369 20068231 22325352 25355358 17157253 16751658 26496610 16714294 26468281 26151332 12183370 12589020 21772249 25843776 20601937 32296183 21676867 27647897 15563468 27705803 16359901 24457600 19636380
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 CHEK1 â—¼   REGULATES ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
CREB1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9528858 19882681 18160048 23447579 11704836
BRCA1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20160719 18851829 9000507 21407215
BRCA1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9926942 11394910 10196224 18025037 21245169 16735508 12647291
PPP1CA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 25056273 12438214 17511879 17603999
CDK1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9244350 21706030 10550055 17570479 19683496 16713569 26745677 32193285 26719576
CSNK2A1 CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25108821 11827172 8206911 1520270 17173306 17329434 26675311 8639568
CALM1 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9952395 8625412 12379661 9728925
USO1 CCNB1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 Reactome 15678101 7737117 11238451 11306556 18167358 1902553 9150144 10679020 9753325 11285137
TP53 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12874009 14627709 10051609 11313928 17942917 11892838 15710382 20395210 19470724 12379461 11071927 11522645 15737644 11162602
CCNH CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7533895 19847258 12814430 17386261 17884153 19667075 15703371 12648680 11900249 12459251 16697054 7799941 19809470
CDK1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23799914 34224728 20117088 16784539 24358021 24508230 19470789 10973963 17283331 20228808 18347064 11242082 12397081 10362260 24582498 15582998 20367638 1833185 12447691 9001210 2570636 24101512 23543736 11331587 12524548 22726437 27626412
CCNB1 WEE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8348613 9001210 19652693 18590585 7575488 12814430 17303408 10373560 7681363 9268380 12124778 15279786 8515817 15037762 17660363 16123593 15070733 15917306
CDKN1A CCNH â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CCNH CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7533895 19847258 12814430 17386261 17884153 19667075 15703371 29793495 12648680 11900249 12459251 16697054 7799941 19809470
CSNK2B CD163 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16713569 11298324
CSNK2A1 CDC34 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11546811 12037680 16123592
CDC34 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10437795 10329681
USO1 CDK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 Reactome 15678101 7737117 11238451 11306556 18167358 1902553 9150144 10679020 9753325 11285137
CDK1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 23508805 23897299 7575488 9892021
CDK1 TERF1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 14551205 15279786 17303408 17660363 18414028 18590585 18625707 22624377 7575488
TP63 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11593387 19861536
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
WEE1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 135.0 1.0 Omnipath 26658951 28126323 15592455 11202906 27196765 20406171 19415658 8578591 22709126 26006103 11730318 20813250 96108162 26025928 11807090 26057002 23410205 24666614 19651622 16096060 15350223 23166842 24716182 8428596 22770610 25174607 28396830 20498628 20530684 25361894 20465818 11527575 25733813 18285803 25283841 25458954 1384126 16497976 17480229 9552418 10564259 24143279 22546375 18669648 7749193 22494620 29930204 18691976 21660227 17192257 9001210 29044141 20347419 23727417 15837193 17016520 19901323 26804466 28928160 21389100 14972559 24415942 24651440 7743995 20068231 25344910 27878946 10209262 27669826 8972180 10896159 28539822 19821025 26131711 25774168 24136233 24536047 23537585 8084605 7774574 24927813 26899266 19305423 25609063 19413330 18385244 25301733 16083285 27196784 18452278 26081366 28264028 29217775 29500418 22836368 11751453 18378775 17718912 20609246 20058876 9268380 27532275 18469858 23494566 24630986 15964826 24970150 12186947
CDKN1A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9467962 26186194 21308745 15340381 23602568 23543736 24218572 17679094 15077146 26496610 12973835
CDK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 17274640 22367880 18088087 17202132 9122166 97225924 10880350
CDK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7592773 30392930 18691976 19387552 20068231 96029687 16371510 1400350 19941816
CDK1 CSNK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16335537 1939094 19007248 17081983 25788269 18691976 20230923 20068231 19387552 17570479 12551973 12396231 19581576 7578274 18669648
CDK1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 25841987 34381492 25691891 27941792 27653691 23549878 25800736 22187039 23241245 25038756 25334066 22964433 27716745 20935635 21131960 29576612 33593912 21123648 23438432 21659531 26552009
CDK1 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19107194 17570479 24011073 28756945
CDK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 17081983 15208671 15070696 15798205 17570479 18669648 15774499 12935893 12586835 12555062 15809305 12740386 11279232 9271440 15235105 12036952 11914378 11872747 14993219 11705993 16964243
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 RAD9A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20021694 12734188 18940270 12709442 24098381 26860083 23028682
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
CDK9 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
TFAP2A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21084835 9473523 16867219 16288208 11420667 18955504 20805990 8988173 17875680 12226108
TP63 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15790310 10383130 21480565 12640112 20123734 17404570 16007146 16410722 15965232 12374749 17965458 21093383 23665236 9405685
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
MAPK14 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23745637 12058028
HUS1 CHEK1 â—¼   PHYSICAL_INTERACTION 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
RAD1 CHEK1 â—¼   PHYSICAL_INTERACTION 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
RAD1 CHEK1 â—¼   SHARES_COMPLEX 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
HUS1 CHEK1 â—¼   SHARES_COMPLEX 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
RAD1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
HUS1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
CHEK1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 19793801 23508805 23897299
RAD1 CHEK1 â—¼   UP_REGULATES ✅ 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
HUS1 CHEK1 â—¼   UP_REGULATES ✅ 38.0 1.0 ACSN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 8943031 9524127
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
PPP2CA CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11390642 17015476
CHEK1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 26610585 27685627 18285803 22730303 18317453 22705496 29977027 19473886 22665067 25852742 25909291 24847116 24204313 15665856 24238855
CHEK1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22152481 23180782
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
CHEK1 WEE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 18677104 15798197 19793801 15070733 19500427 17116885 17582221 17384638 23897299 7681363 20068082 19230643 15459660 26930412 9268380 23508805 17296725 28396830 17102137 8515817
CLOCK CRY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17660446 22750052 16628007 20852621 11798163
CLOCK PER1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15193144 22895791 20930143 17660446 10848603 22750052 12397359 20106950 19341811 20551151 20852621 21479263 19605937 15147242 17994337
CLOCK PER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 14672706 17660446 19168071 22750052 21960634 24051492 23469106 24498074 20852621 11798163
CREB1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 11160957 11698596 12842905 9770464
CREB1 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 11160957 11698596 12842905 9770464
CREB1 PPP2CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17526027 19155497 19750005
CREB1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 2170405 22357921 8648265 15908479 1845987 8803927 2542772 15608673 1404598 1320003 12372774
CREB1 GRIN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15774772 16313514 23012887 22364833
RPS6KA4 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11175347 12356771 15733869 11160957 23331499 9792677 9829964 7958915 12235136 9687510 17158541 15187187 18813292 17668895 8887554 11698596 8688081 9528766 11018520 11969286 11909979
MAPK14 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11175347 12356771 15733869 11160957 11532940 7958915 9829964 12235136 16189514 11335727 9687510 8887554 11698596 23532963 8688081 9528766 11018520 11969286 11377386 11909979
MAPKAPK2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11175347 17389598 10679065 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 20626350 11909979 8688081
RPS6KA2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 9829964 11698596 11018520 11160957 11969286 12235136 7958915 9687510 11909979 8688081
RPS6KA5 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 11175347 12356771 15733869 11160957 28593137 23331499 9792677 7958915 16223362 9829964 12235136 12763014 9687510 18988627 17158541 15187187 18813292 8887554 11698596 8688081 9873047 9528766 11018520 11969286 11909979
RPS6KA3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 9770464 9829964 11018520 11160957 11698596 11969286 12235136 17570479 7958915 9687510 1545823 11909979 8688081
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
FBXL17 CRY2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17463251 20304803
STAT5A CSN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 10993888 9341115 8274437 8830676 12746331 19490989 9973262 12060651 18583090 11751614 16973758 10471471 1491685 10418993 15746097 10358045 11604235 18024957 23313770 9252424 12596040 15534001 9806359 9231797 12954634 11167825 11287629 12459499 10732325 7519723 9817603 14646587 8018556 12082616 10834938 12605675 9657743 12732616 8264581 8943229 20980837 16832345 16965262 9343435 11158330 7514531
CSNK1E TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10606744 11709713 10951572 10734067 16713569 11551930 10747897 10673501 11883897
CSNK1E PER2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 17145710 17218251 23555304 9349507 30425162 21324900 15767683 32296183 24857656 11475410 17218255 11232563
CSNK1E PER1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11865049 23555304 15148313 10848614 15917222 26496610 16189514 16750171 23455922
CSNK1E CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 9312064 7641885 15265686 19718039 21602792 14966280 210606194 8655584 19705439 11818547 19029934 20093472 17430994 21606194 17884187 11955436 9482734 14747478 17570479 12176352 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 12000790 12114015 16547521 10488109 19020754 20940130 12417018 21640127 21087212 17127310 21796133 10023673
CSNK1G2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10606744 11709713 10951572 10734067 11551930 10747897 10673501 11883897
MAPK14 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15649893 14580335 16648474 15371334 17072322 10747897 17255949 11274345 12697810
NOLC1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17038328 7657714 18790693
CSNK2A2 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 26186194 27705803 25519132 19011756 26496610 25852190 23455922
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
CSNK2A1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 10783893 16007147 9721103 11673497 12138192 10723127 7796813 8657113 8622692 10421793 12167702 12403772 8668171 8657102 10398585 8601309 9214631
CSNK2A1 TNFAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19851886
CSNK2A1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17287340 19413330 22113938 18669648
CSNK2A1 TFAP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21777522
CSNK2A1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17145710 16873060 19380586
CSNK2A1 SSB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17081983 10715123 16083285 9054510 18257391 15485924 97207017 19039329
CSNK2A1 FAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12832043 11378439 11713579
CSNK2A1 RNF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16874460 12748192
CSNK2A1 SSRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 19007248 15659405 20068231 17287340 22113938
CSNK2A1 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18347021
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2A1 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21474068
CSNK2A1 EIF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 19651622 19415658 17081983 16227438 18691976 11861906 20068231 18452278 17287340 19413330 18669648 18649047
CSNK2A1 MME â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22767595 20957047
CSNK2A1 CTNNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20858269 31432583 20093040 32256776 19941816
CSNK2A1 FUNDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 27757847 24746696 29540794 30591555 27653272 25126723
CSNK2A1 CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 12591939 19664994 19215094 19664995 15723518 18669648 15302935
CSNK2A1 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16225457 19651622 17081983 18691976 20068231 18452278 8024572 22113938 18669648 12901717
CSNK2A1 GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 29423241 15537897
CSNK2A2 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 10783893 16007147 9721103 14580335 12138192 10723127 7796813 16410802 12403772 10421793 8622692 17570479 8657102 10398585 8601309 9214631 9724653
CSNK2A2 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17570479 17287340 19413330 18669648
CSNK2A2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12700239 19141652 12432063
CSNK2A2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16083285 1088347 10348343 10884347 16552184 9315650 10747897
CSNK2A2 CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 12591939 19664994 19664995 18669648 15302935
MAPK14 CSNK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15649893 16648474 15371334 17570479 17072322 10747897 17255949 11274345 12697810
CSNK2B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12432063
CSNK2B RNF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11710515 10512750 12748192 12470599 16713569
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
CSNK2B NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10764587 16410802 14580335 9724653
CSNK2B CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 12591939 19664994 19664995 18669648 15302935
CSNK2B USO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19651622 19415658 20166139 10931861 20068231 18452278 9478999 11396975 19413330 19664995 18669648
CSNK2B EIF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19651622 19415658 17081983 16227438 18691976 11861906 20068231 18452278 17287340 19413330 18669648
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
SRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 22605996 16492141 27177845 23824743 25423132 25850673 24816560 27203386 11836526 22515442 26918136 10593980 15782139 9592087 22056988 12571228 17087658 20840866 23640056 21195420 25164010 26453937 9278444 16831887 23476652 12123611 11279024 14517306 21903109 22200182 20026641 22264731 25041845 12408824 22247700
DAXX FAF1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FAF1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FAF1 â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12954772 21482821 21134643 16845383 25241761 15364927 16713569 12482984 15339933 23038753
DAXX MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17145710 21134643 16845383 15364927 18566590 23405218 18583933 20195357 23038753
EIF5 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10805737 11092890 9395514 16189514
HDAC1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
MAPK14 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21902831 30022044 17570479 27494834 28067271
FN1 PTK2 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
NFKB1 FTH1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 15537542 21725609 23178297 23572150
SRC FUNDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 25810907 27757847 29370689 24903109 27995894 26258123 29951054 26501336 29278362 22267086
STAT5A GH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10674400 7744007 8732682 11092411 12683938 18388193 22698918 19819986 22166977 11564677 14532269 17412814 12970402 10373481 15677453 10803577
SRC GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10884433 10458595 10195142 23933820 12932824 10846184 29063113 26942227 19834457 33037073 11677266 26441533 20448061
SRC GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10884433 18184784 11483655 11024032
UBE2I HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11960997 12032081 15199155 24068740
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
MECOM HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11552981 23858473 16713569 11568182
UBE2I HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12820959 15340381 11960997
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
TP53 HMGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
HMGB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
NFKB1 HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17724475 21725609 23178297 23572150
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 1310678 16844778 16189514 18266962
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HUS1 RAD1 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 15871698 16216273 16697054 16713580 16731526 16805667 16879101 16885023 17102137 17116885 17129768 17296725 17303408 17384638 17395641 17426133 17493829 17582221 17855402 18469862 18543256 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 23507534 8943031 9524127
HUS1 RAD1 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 15871698 16216273 16697054 16713580 16731526 16805667 16879101 16885023 17102137 17116885 17129768 17296725 17303408 17384638 17395641 17426133 17493829 17582221 17855402 18469862 18543256 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 23507534 8943031 9524127
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
RPS6KB1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 21283818 17081983 16953237 24931005 11287630 15249583 27898058 16914728 25379019 23565163 15364919 15533996 19121779 9312143 17709744 20074531 22523661 23958494 16129690 23006971 23898460 26474286 28342808 17507185 25813876 26926384 15306821 20932932 34013180 15199052 18498745 18952604 18220336 12006582 19369195 29496905 27889207 26666849
PRKCZ IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11063744 16129678 16611834 14583092 17360977 15212693 15516986 15069075
ITGA4 LYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGA4 PTK2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
LYN MAP4K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11487585 17570479 11514608
LYN MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11131153
LYN STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11413148 17081983 7925280 11641791 9573010 15212693 8617237
LYN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9169439 11369622 11389892 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
NCF1 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16778989 25877926 14530365 27558335
MAPK14 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 21675959 16456544 23602568 17395714 21988832 10581204 23331499 21071413 27898710 23047924 10922375 12738796 11551945 26496610 25852190 18988627 15629715 18669648 15187187 11042204 26186194 25241761 8846784 17906627 14499342 9922370 7923353 9768359 18039929 25255283 7592979 17255097 11274345 23455922
MAPK14 RPS6KA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 10806207 17145710 23602568 20506250 11035004 23331499 21614932 20068231 9792677 16393692 10922375 17570479 25852190 15187187 26186194 15140942 18691976 18813292 19651622 19436832 11157753 16964243 11274345
MAPK14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15187187 21675959 18039929 12738796 23397142 11238443 11274345 12697810
MAPK14 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 21675959 26247731 20213747 17535811 20506250 15657900 9315650 15642743 19413330 11283254 22975381 10581258 16083285 1088347 21614932 16393692 10884347 21050851 16552184 10747897 15187187 17906639 25789565 15140942 11258706 24818748 19436832 10781582 10212189 17172861 10348343 11078726 11274345
MAPK14 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 14580335 16410802 8622692 8668171 9724653
MAPK14 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 20506250 15302935 17117922 23047924 21614932 20068231 10922375 16393692 9687510 15187187 20936779 26186194 19940164 15140942 18813292 15568999 19651622 19436832 14578350 11157753 15684425 11994045 11274345
PRKCZ MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11035106 12942541 23109003 12900386 15721486
PPP2CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 18588945
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 NCF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11485312 11535139 8626435 16778989 7520867 15629715 94375440 8089108
MAPK3 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 15547943 20080742 14967450 12040186 15173823 12697810 11940578 16227978 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 11279232 9271440 18039929 18775330 10601235 12792650 11431469
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18156174 25241761 12832467 8939914 9915826 17906627 10980595 10856237 19282669
MAPK3 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 23602568 8939914 12832467 17906627
MAPK3 RPS6KA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15187187 17145710 23331499 19541618 19565474 20506250 17052211 15547943 9792677 16393692 17255949 11274345 12697810
MAPK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9804779 20508164 23331499 24263804 18775330 10194762 12407017 8226933 17502367 34188118 9604935 18988627 31932645 8388392 12091337
MAPK3 RPS6KA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 20506250 15547943 15302935 12697810 12414794 17117922 20068231 16393692 19251839 17255949 15187187 19541618 19565474 18813292 17052211 15568999 19651622 14578350 11891214 11018520 15684425 11994045 11274345
MAPK3 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21675959 17242355 7592979 14499342 14967450 23583303
MAPKAPK2 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19738896 15688025
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
UBE2I MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15195100 12759344 14507915 16713569 12915590
PRKCZ NCF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 8626435 12734380 96198102 11145703 12056906 94375440 8089108
RPS6KA5 NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 STAT5A â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12208876 21725609 23178297 23572150
NFKB1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 1829648 21725609 23178297 23572150 8096091
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
NFKB1 NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17876798 15499023 17709515 7775482 11744993 10454561 11060311 12885753 9250151
NFKB1 VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20966071 22708120 16317091 16271621 10833420 10496926 16249517 7536741 19281832 10553096 19422386 7537851 16385502 10946302 16453001 10329958 11359843
NFKB1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 17145710 25609649 7862124 1340770 16210649 16970925 21719482 9738011 9865693 10497169 8657102 9572494 9315679 21988832 8887676 10329681 1829648 14743216 17003112 11313474 20558726 26496610 7867065 7891711 10837071 7831327 15836773 26186194 11571291 15214841 17561400 16846590 9566883 8096091 15371334 7479976 11020244 9426183 16493424 15145317 8631829 20237821 20980497 16513645 9597130 7479848 7739549 7628694 10655476
SIRT1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19408108 15152190
SRC NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 24216290 12432072 24637265 12429743 25671697 14991073 8797825 24101387 9792645
NPAS2 PER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22039518 17660446 16636276 11441147
NPAS2 PER1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17660446 20817722 11441147
SRC OCLN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12547828 25377781 12604349 20152177 15782139 16492141 9278444 9592087 24349408 22315516 19017651
POT1 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
PPP1CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16501611 16713569 15231748 15178317
PPP1CB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16501611 15178317
PPP1CC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 17274640 15178317 16501611
SRC PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 25003662 10978272 21292165 23796501 24676687 22771321 24395787 17635907 26378614 16286244 27013170 23222956 25726524 24997451 31992581 12921784 1325671 17303700 23251465 20558158 21554241 23926298 25931585 22299660 18208556 21791414 23436320 32130916 17394530
TLX1 PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15897879 9009195
PPP2R1B PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18715871 17540176 19114990
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17245430 14712210 1848668 16713569 12556559
PPP2CA RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16109716 2826472 16899564 11438723 11124802 10200280
PRKCI SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 11713277 15567848 14585353
PRKCZ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 10527887 11447289 19615955 16488589 6321473 8321321 12845332 11313945 16189514 12040186 19568798 15567848 14585353
SRC PTK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11476890 12531888 16919435 17496910 17517963 20027185 25572304 26552706 27216177 8892616
TP53 PTK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24809783 20515733 21355845 21071137 21269258 18493017 17999388 17725966
SRC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 216.0 1.0 Omnipath 27351421 23242524 16254240 12370821 21940449 26142360 17525734 10593973 14604860 17389395 19171305 22402981 19339212 22353809 9748249 8941336 17570479 12464388 25226367 15611085 15817476 25241761 26393679 27978555 26833789 11927607 17828307 25913180 26866924 15247219 10085298 12387730 19055942 9507031 21454698 10973994 32814053 21057587 27931517 27438371 18793427 19695571 15735019 18560762 10592173 25319025 24389213 21852560 26689988 14984767 7505391 19568240 20103658 20822514 25868388 23275294 28423510 23764511 19625610 15561106 17192257 19138410 19369195 17088251 12753909 28701735 29190494 17016520 15598735 18814847 11821402 11418135 15728464 16291744 25067788 11602246 16713569 22287273 9032297 7997267 12960434 11369622 20616959 26079101 19534553 10931187 22710722 20068231 25866790 21347260 9822703 28202937 16153436 11980671 21855630 19826415 18464795 7529876 20621036 9330873 21473875 9425168 28956212 12615911 15951569 25814554 12876384 17438336 15212693 16966330 20705914 20847951 23729178 20407018 12558988 25127991 25918719 12590707 16360410 8054685 18814027 11696015 22800863 17117420 12495636 11278488 9864370 21776383 18083107 22814579 22194915 20515733 11119718 9148935 10428489 15743500 20655298 23065768 28213315 26923073 24015220 17289681 12110680 22006118 24164353 23109003 18935208 10753828 18233957 8816475 25118939 19664994 25530216 16760434 9330875 21266176 21034468
PTPN12 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19595712 10400703 9497381 21876001 11432829 11314030
TP53 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18431400 25241761 15855171 18206965 19857493
PTPN12 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19595712 18482983
STAT5A RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16398215 12024032 15626738
TP53 RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17513613 16322760 20802511 16398215 18769160
TP53 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 8617246 11002423 16713569 16322760 16983346 9380510
SRC RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18156174 12601080
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
SRC STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11413148 17081983 10358079 22090359 7925280 16189514 15702476 11641791 15212693 8617237
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP53 FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.12 1.11 PKG 28854368
TP53 FN1 â—¼   KO_UP_REGULATES ✅ + 2.36 2.36 PKG 28854368