PIN1
|
DDX24
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
TOPBP1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17006541
5219150
|
TOPBP1
|
AKT1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
17006541
5219150
|
AKT1
|
FLNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15461588
17570479
|
UBE2I
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
SUMO2
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22661230
22635276
|
SUMO1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
DCLRE1B
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19411856
|
ATM
|
PLK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12147700
|
BRCA1
|
KPNA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5221252
8955125
|
TP53BP1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15970701
21914189
|
FANCD2
|
BRCA1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
11239454
5213674
|
PIN1
|
CSNK2A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11940573
5215253
|
CSNK2A1
|
CSNK2B
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
PARP1
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
23045548
23319653
|
HSPB1
|
DDX39A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RAD51C
|
EME1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
XRCC3
|
EME1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
HNF4A
|
SERPINA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9927755
10330009
|
HNF4A
|
TF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8550563
9053305
|
HSPB1
|
PIAS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PLK1
|
MAGED1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
SUMO1
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
UBE2I
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
MRPL41
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
MRPL41
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
RAD51C
|
MUS81
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
XRCC3
|
MUS81
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
NBN
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
NBN
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22661230
22635276
|
NBN
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
NSMCE2
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19308705
|
NSMCE2
|
TERF2IP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19308705
|
NUP155
|
NUP188
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
PARP1
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
PARP1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
PARP1
|
RNH1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8086497
21276451
|
SUMO1
|
PARP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19622798
|
SUMO3
|
PARP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19622798
|
PLK1
|
TP53BP1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
1000287
20126263
|
RAD51C
|
RTEL1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
22593209
18957201
|
RAD51C
|
SLX1A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
RAD51C
|
SLX4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
TP53BP1
|
RAN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SUMO1
|
RANGAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17036045
5219211
|
RPA1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
24782567
20705237
|
RPA1
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
24782567
20705237
|
RPA1
|
SUMO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
24782567
20705237
|
XRCC3
|
RTEL1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
22593209
18957201
|
XRCC3
|
SLX1A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
XRCC3
|
SLX4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
24076221
24831703
|
SUMO1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20016603
25114211
|
SUMO3
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11451954
17938407
|
SUMO2
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22661230
22635276
|
TERF2
|
TP53BP1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21824286
8202878
|
TOPBP1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18923429
7296625
|
TOPBP1
|
TP53BP1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8086392
20871591
|
UBE2I
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22661230
22635276
|
RAN
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
NUP155
|
NUP188
|
â—¼ CORRELATES
|
|
+
|
0.8
|
0.8
|
CCLE
|
31978347
|
DDB1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
27354282
24412650
|
SUMO2
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
32786267
19471022
22661230
19394292
|
UBC
|
SQSTM1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
5216530
12857745
|
ATM
|
PLS3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.82
|
0.81
|
PKG
|
28854368
|
GFM1
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
812.0
|
0.81
|
STRING
|
36370105
|
GFM1
|
MRPL41
|
â—¼ PHYSICAL_INTERACTION
|
|
|
813.0
|
0.81
|
STRING
|
36370105
|
ATM
|
LARP7
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.81
|
0.81
|
PKG
|
28854368
|
GFM1
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
815.0
|
0.81
|
STRING
|
36370105
|
GFM1
|
MRPL44
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
MEPCE
|
IMA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17643375
29845934
|
NBN
|
TE2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22939629
34079125
|
TE2IP
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
15383534
34079125
|
MUS81
|
XPF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
MICU1
|
GPN3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
28514442
|
SLX4
|
KEAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31495888
19596235
|
ATM
|
CHEK1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
20068082
|
ATM
|
TSPYL1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
MRPL15
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
MRPL15
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
MRPL9
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
MRPL9
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
NBN
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
ATM
|
MDC1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
12607003
|
MSH3
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HuRI
|
32296183
|
MRPL44
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
826.0
|
0.82
|
STRING
|
36370105
|
NUP155
|
NUP93
|
â—¼ CORRELATES
|
|
+
|
0.82
|
0.82
|
CCLE
|
31978347
|
BRCA1
|
TE2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34112789
29656893
34079125
|
ERCC1
|
CT094
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
26186194
31495888
|
PLK1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
31730000
25483079
29656893
24067368
|
BRCA1
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
19797051
25184681
29656893
34112789
|
GPN3
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
33961781
28514442
26186194
|
AKT1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
ATM
|
NBN
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
10802669
|
SPRTN
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
BRCA1
|
FANCD2
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
12485996
|
MRPS16
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
MRPS16
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
MRPL44
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
NUP188
|
NUP93
|
â—¼ CORRELATES
|
|
+
|
0.83
|
0.83
|
CCLE
|
31978347
|
PARP1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
NUP153
|
NUP93
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.83
|
STRING
|
36370105
|
AKT1
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
24412244
28205554
28628118
|
PARP1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
34079125
26831064
25252691
|
HNF4A
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
35140242
22505616
|
TP53BP1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
NUP153
|
RAN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
849.0
|
0.84
|
STRING
|
36370105
|
SUMO2
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
21147198
20016594
20016603
22689573
21693764
|
SUMO2
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
19471022
25027693
32786267
19779455
21252943
21693764
|
SLX4
|
RTEL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
31495888
32398829
|
MEPCE
|
PRPF31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
MDC1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
855.0
|
0.85
|
STRING
|
36370105
|
SLX4
|
IMA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
33961781
19596235
|
TE2IP
|
PPM1G
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
21044950
34079125
|
CT094
|
XPF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31495888
19596235
|
BRCA1
|
FLNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
22990118
26831064
16713569
20305393
|
MEPCE
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
17643375
21145461
|
SLX4
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31495888
19596235
|
PPM1G
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
27880917
34079125
|
SUMO1
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
19779455
15561718
23871147
15576338
19596686
|
SLX4
|
PGAM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31495888
19596235
|
SQSTM1
|
PRKCI
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
20808283
8075909
|
SUMO1
|
SUMO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
24654937
25027693
17938407
21098080
15576338
|
CHEK1
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
861.0
|
0.86
|
STRING
|
36370105
|
BRCA1
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
ERCC4
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
PCNA
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
ERCC4
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
MRE11A
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
MRPL44
|
MRPS11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
PSMB4
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
MDC1
|
LARP7
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.87
|
0.86
|
PKG
|
28854368
|
IMA1
|
NUP50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33961781
32296183
25416956
26496610
26186194
28514442
|
PLK1
|
CT094
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
32707033
19596235
|
SLX1
|
PLK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
32707033
19596235
|
SLX1
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
19595721
19596235
|
BRCA1
|
MRE11A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
14578343
11498787
|
MRE11A
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
PCNA
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
KEAP1
|
PGAM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
MRE11A
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ATM
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
NUP155
|
NUP93
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
PCNA
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
PIN1
|
POLR2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
GFM1
|
MRPS11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
GFM1
|
MRPL15
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
LARP7
|
MEPCE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
GFM1
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
PIAS1
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.87
|
STRING
|
36370105
|
SLX1
|
XPF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19595721
19596236
19596235
|
SLX1
|
ERCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
19595721
19596235
|
SLX1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19595721
19596236
19596235
|
ATM
|
PEX5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
10567403
26344566
|
GFM1
|
MRPL9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
MDC1
|
MRE11A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
MDC1
|
FLNA
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.88
|
0.88
|
PKG
|
28854368
|
SPRTN
|
VCP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
UBR5
|
IMA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12011095
16713569
|
PLK1
|
XPF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
33961781
25659891
28514442
32707033
19596235
|
MDC1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
29656893
26734725
12607005
14519663
18006705
28943310
|
MDC1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21622030
17525332
15569676
29656893
12607005
19766185
12611903
|
NBN
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10426999
29656893
10783165
11504724
25659039
25939603
25184681
19244116
18171670
12124328
|
BRCA1
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
26831064
18025037
20016594
|
SLX4
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31495888
32398829
19595721
19596236
19596235
|
MEPCE
|
LARP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17643375
33961781
29845934
18483487
26725010
24778252
18281698
|
TERF2
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22939629
10888888
19287395
|
PLK1
|
PIN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10037602
9499405
16118204
16713569
16189514
|
MDC1
|
TOPBP1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.89
|
0.89
|
PKG
|
28854368
|
ERCC1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.89
|
STRING
|
36370105
|
IGHM
|
TK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
TE2IP
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24981860
22939629
26496610
28082411
21044950
26450775
26344197
10850490
21829167
16880378
19287395
23307557
27214791
15316005
23086976
15100233
15383534
29126443
21217703
19164295
10888888
19651898
14565979
34079125
|
SLX4
|
TE2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22902628
31495888
19596235
|
SLX4
|
XPF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
26453996
22902628
23093618
23623386
32398829
25538220
31495888
23033263
21240275
19595722
19596236
19595721
24012755
23994477
19596235
|
SLX4
|
CT094
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22902628
31495888
32398829
19596235
|
SLX4
|
SLX1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23093618
31495888
32398829
19595721
19596236
24012755
19596235
|
ATM
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15546863
15899889
|
ALB
|
TK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
RPA1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18171670
11080452
17965729
|
BRCA1
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11498787
16260778
25184681
10783165
|
CSNK2A1
|
TCOF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25064736
|
SUMO2
|
CSNK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
SLX4
|
ERCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22902628
23093618
23623386
31495888
25538220
32398829
23033263
21240275
26186194
19595721
19596236
28514442
19596235
|
RPA1
|
ERCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
14517266
19940136
17948053
|
ERCC4
|
SLX4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
NUP50
|
KPNA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
31515488
32296183
25416956
|
SLX4
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22902628
31495888
32398829
19596235
|
MSH2
|
TK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
SLX4
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23033263
29850896
21240275
21516116
25533185
23994477
22902628
31495888
19596235
32296183
23093618
32398829
19596236
28514442
25416956
29892012
23623386
19595721
24012755
25224045
|
TCOF1
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25064736
|
UBE2I
|
PARK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11477070
15976810
18339323
|
SUMO1
|
PARK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11477070
15976810
18339323
|
SUMO2
|
PIAS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22578841
19471022
19394292
20016603
16524884
21252943
18806873
19217413
21693764
|
SLX4
|
PLK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25852190
22902628
31495888
25659891
32707033
19596235
|
RPA1
|
VCP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
22902628
23042605
23042607
|
RPA1
|
TK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
VCP
|
SPRTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
22902628
23042605
23042607
|
SUMO3
|
TK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
MRPL15
|
MRPS11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
901.0
|
0.9
|
STRING
|
36370105
|
NUP155
|
SEH1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
PRKCI
|
SQSTM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
906.0
|
0.9
|
STRING
|
36370105
|
ERCC1
|
SLX4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
MSH2
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
909.0
|
0.9
|
STRING
|
36370105
|
ATM
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
CWC15
|
SDE2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
IPO7
|
RAN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
PIAS1
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
ATM
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
MRPS11
|
MRPS21
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
MSH3
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
MRPL41
|
MRPS11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
915.0
|
0.91
|
STRING
|
36370105
|
MDC1
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
MUS81
|
SLX4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
918.0
|
0.91
|
STRING
|
36370105
|
MSH2
|
MSH6
|
â—¼ CORRELATES
|
|
+
|
0.91
|
0.91
|
CCLE
|
31978347
|
RPA1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
RAD51C
|
XRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
921.0
|
0.92
|
STRING
|
36370105
|
MRPL9
|
MRPS11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MRPS11
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
SQSTM1
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
926.0
|
0.92
|
STRING
|
36370105
|
NUP188
|
NUP93
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
UBC
|
VCP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
MRE11A
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
UBC
|
UBR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
PCNA
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
8858149
16189514
12171929
15225546
|
MRPL44
|
MRPL9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
FANCD2
|
UBC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
942.0
|
0.94
|
STRING
|
36370105
|
RAN
|
RANGAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
944.0
|
0.94
|
STRING
|
36370105
|
MRPL9
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
GID8
|
RANBP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
UBE2I
|
RANGAP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
17036045
5219211
|
UBE2I
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5219915
17491593
|
MDC1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
951.0
|
0.95
|
STRING
|
36370105
|
MDC1
|
AHCYL2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.96
|
0.95
|
PKG
|
28854368
|
RANGAP1
|
SUMO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
954.0
|
0.95
|
STRING
|
36370105
|
MRPL41
|
MRPL9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
956.0
|
0.95
|
STRING
|
36370105
|
MRE11A
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
MRPS11
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
NUP153
|
NUP50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
960.0
|
0.96
|
STRING
|
36370105
|
PIAS1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
SUMO3
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
CHEK1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
967.0
|
0.96
|
STRING
|
36370105
|
MRPS21
|
MRPS31
|
â—¼ PHYSICAL_INTERACTION
|
|
|
969.0
|
0.96
|
STRING
|
36370105
|
ATM
|
MRE11A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
NBN
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20224574
7891431
|
MRPL44
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
MSH3
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
33961781
16025128
8942985
22179786
22939629
8805365
14657349
9774676
10029069
19377479
|
TERF2IP
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8286516
21829167
|
KEAP1
|
SQSTM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
PCNA
|
SPRTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
DCLRE1B
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
NBN
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
MSH6
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
SLX4
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
975.0
|
0.97
|
STRING
|
36370105
|
MRPL15
|
MRPL9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
977.0
|
0.97
|
STRING
|
36370105
|
AHCYL1
|
AHCYL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
KPNA1
|
NUP50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
979.0
|
0.97
|
STRING
|
36370105
|
CSNK2B
|
CSNK2A1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
36833176
|
RANGAP1
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
980.0
|
0.98
|
STRING
|
36370105
|
TERF2
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
MRPL15
|
MRPL44
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
MRPL41
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
MRPL15
|
MRPS16
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
XPF
|
ERCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
33961781
17289582
19940136
22939629
14706347
26453996
23580445
26344197
25956741
31495888
25538220
14734547
15932882
16338413
8197175
9722633
24036546
26085086
10413517
22353549
17912758
21466675
9013642
28514442
11160918
24780295
16076955
26186194
21875596
|
MRPL41
|
MRPL44
|
â—¼ PHYSICAL_INTERACTION
|
|
|
990.0
|
0.99
|
STRING
|
36370105
|
MSH6
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
33961781
9428522
15064730
26344197
8942985
10748159
22939629
25241761
26496610
14657349
10856833
9774676
10783165
10029069
19377479
|
PCNA
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
SUMO1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
BRCA1
|
POLR2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
SUMO2
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
MRPL15
|
MRPL41
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
RANGAP1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
TOPBP1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
PRPF31
|
SART1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
ERCC1
|
ERCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
CSNK2A1
|
CSNK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
0.99
|
STRING
|
36370105
|
POLR2A
|
POLR2G
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
0.99
|
STRING
|
36370105
|
AKT1
|
ZYX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
17572661
|
PCNA
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10858306
11756412
11948190
12637553
14624239
14726013
15703371
15871698
16442856
16697054
16731526
17088286
17116881
18087292
18584027
18809224
19208614
19364882
1974050
19748837
19772495
19847258
20056333
20478261
20510258
20603072
21251944
21270334
21376743
22021614
22055391
22469522
22713970
22743550
22921416
23145148
23414611
23562323
23568489
24050180
24210699
24684389
24976506
|
PCNA
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
20713735
20154325
22118461
11274057
11441019
11005803
18326858
17984070
11809883
16188885
16143102
|
PCNA
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
47.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
1974050
19793801
19847258
20051983
22021614
23414611
|
PCNA
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17720710
12226657
18342608
20129063
|
PCNA
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
47.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
1974050
19793801
19847258
20051983
22021614
23414611
|
PCNA
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
PCNA
|
PARP1
|
â—¼ SHARES_COMPLEX
|
|
|
43.0
|
1.0
|
ACSN
|
10858306
11756412
11948190
12637553
14624239
14726013
15703371
15871698
16442856
16697054
16731526
17088286
17116881
18087292
18584027
18809224
19208614
19364882
1974050
19748837
19772495
19847258
20056333
20478261
20510258
20603072
21251944
21270334
21376743
22021614
22055391
22469522
22713970
22743550
22921416
23145148
23414611
23562323
23568489
24050180
24210699
24684389
24976506
|
PCNA
|
BRCA1
|
â—¼ SHARES_COMPLEX
|
|
|
49.0
|
1.0
|
ACSN
|
11756412
11850621
11877377
11927554
12239151
12551922
12607003
14624239
14726013
15459660
15703371
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18584027
18809224
18931676
19075014
19217432
19264559
19622404
19686080
1974050
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20723763
21060331
21337561
21376743
21574959
22021614
22101340
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
CSNK2A1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
29732088
17374729
21506126
11689703
10671551
12149249
15818404
10747897
10837139
20976471
19662498
21285348
11035045
11707428
21735093
17444818
20558317
11972058
16707567
|
AKT1
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
20832017
18691976
23108403
17418864
20068231
12062056
15107605
17570479
19664995
18669648
26091525
|
AKT1
|
VCP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16551632
19335618
16027165
|
AKT1
|
TBC1D4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
17081983
23801578
17274760
19690332
26465605
19413330
12637568
16083285
17617058
18669648
18276765
11994271
16880201
15616009
18220336
19252894
18771725
20410134
16964243
26822091
|
AKT1
|
HSPB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
12740362
11042204
19593530
22983196
17510053
23397142
|
AKT1
|
TOPBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
24081328
17913746
33556369
17006541
|
AKT1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
17428466
20832017
20085797
21242970
17570479
10542266
|
BRCA1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
ATM
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
MDC1
|
â—¼ SHARES_COMPLEX
|
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
MDC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
FANCD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
PARP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
MSH2
|
ATM
|
â—¼ UP_REGULATES
|
✅
|
+
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MSH6
|
ATM
|
â—¼ UP_REGULATES
|
✅
|
+
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
ATM
|
MDC1
|
â—¼ REGULATES
|
✅
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
RPA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
17525332
11359916
|
ATM
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
80.0
|
1.0
|
Omnipath
|
12433983
12861053
17485521
23146902
10839545
19413330
15302935
27602502
17429352
19523210
24360018
20068231
17507690
17570479
10608806
12598907
18669648
25088203
18003706
11252893
17431132
23097684
10766245
12814430
10802669
21664921
26512707
10839544
11927276
21130714
17525332
12447395
14707289
15733840
15279770
25119968
18644472
28822740
|
ATM
|
SLX4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21655083
17525332
|
ATM
|
MDC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17145710
28193847
21705321
22234877
12607003
12607005
22234878
17525332
18006705
|
ATM
|
PEX5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
26344566
10567403
26967755
|
ATM
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
69.0
|
1.0
|
Omnipath
|
29774099
20976184
26683224
25663895
12676583
17303408
14657349
29167438
27545311
10859164
19056039
15485915
28808226
12588868
16163361
15650047
12676962
17570479
14988723
14681223
26516160
10608806
26069190
29741650
12676925
23847781
17118344
11252893
20376879
15964794
15149599
18691976
19059218
20068082
15707391
12607003
25450480
17525332
11553781
19646247
15870257
15459660
20798862
19716789
11877377
12660173
11390642
15674326
16782033
28396830
28228262
12446774
15533933
15212693
29555944
|
ATM
|
TOPBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
11756551
18077418
19279141
17525332
17446169
|
ATM
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
16280053
17303408
15057286
12427531
15607958
25891850
16163361
21466974
20068231
14499622
17570479
12086603
19774700
23847781
14599770
15964794
22057367
28825622
12607003
17525332
15459660
16943440
15979372
11877377
27094386
15279770
28552166
12612651
19101576
|
ATM
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16223874
17525332
15314656
|
ATM
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
11042216
17940005
26247731
18996087
19876065
16945145
12447390
22621922
18644834
19650866
24320053
18077418
17570479
17690115
17525332
12697768
|
ATM
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
26927092
17303408
15159397
24746700
12024016
10866324
30197789
12919958
11114888
26745677
26383678
34301763
12427729
11313470
16163361
28035057
20068231
25939603
26320175
17570479
19683496
22743550
10608806
23802008
23847781
21203981
15964794
12183412
12607003
17525332
19996295
15459660
11278964
19651622
21706030
11877377
20952512
10373534
19622773
10550055
27170701
15212693
23704879
|
ATM
|
PPM1G
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
26324325
17525332
|
BRCA1
|
FANCD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
56.0
|
1.0
|
ACSN
|
11850621
11877377
12607003
14726013
15459660
15485915
15496928
15549137
15655342
15703371
16697054
17088286
17116881
17965729
18001825
18087292
18171670
18171986
18212739
18584027
18716619
18809224
19202191
19208614
19217833
19270065
19357644
19364882
19490890
196269035
19772495
19793801
19847258
20021983
20029420
20051983
20064462
20603072
20723763
21060331
21270334
21337561
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
9721205
|
BRCA1
|
XRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
BRCA1
|
SUMO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
20016603
25218447
20016594
21147198
|
BRCA1
|
FANCD2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
XRCC3
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
BRCA1
|
PARP1
|
â—¼ SHARES_COMPLEX
|
|
|
56.0
|
1.0
|
ACSN
|
11850621
11877377
12607003
14726013
15459660
15485915
15496928
15549137
15655342
15703371
16697054
17088286
17116881
17965729
18001825
18087292
18171670
18171986
18212739
18584027
18716619
18809224
19202191
19208614
19217833
19270065
19357644
19364882
19490890
196269035
19772495
19793801
19847258
20021983
20029420
20051983
20064462
20603072
20723763
21060331
21270334
21337561
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
9721205
|
TP53BP1
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11042216
11877378
17243194
18087291
19342239
20646866
9748285
|
MDC1
|
BRCA1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
17303408
17660363
18001824
18006705
18087291
18583988
18590585
18678890
7575488
9407949
|
BRCA1
|
CHEK1
|
â—¼ REGULATES
|
✅
|
|
22.0
|
1.0
|
ACSN
|
10367887
10779360
10962562
11877377
12024039
12170778
12496474
12771027
15242590
15459660
15485915
16818604
19004803
19357644
19686080
19788416
19793801
20029420
21060331
21337561
9346961
9892649
|
MDC1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
18087291
17525332
12607005
|
BRCA1
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12887909
12485996
11239454
25652403
14499622
16713569
|
DDB1
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
19748355
12504025
18805092
15688063
18851830
23453757
15537541
23535663
11961546
21463634
12504026
12609982
23535662
21863050
|
TOPBP1
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
CHEK1
|
RPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
TOPBP1
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
TOPBP1
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
CHEK1
|
FANCD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
14988723
15459660
15798197
17102137
17116885
17296725
17384638
17582221
18677104
18931676
19686080
19793801
|
CHEK1
|
RPA1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
CHEK1
|
RPA1
|
â—¼ REGULATES
|
✅
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
CHEK1
|
FANCD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
17296725
19686080
22057367
19861535
18677104
15798197
17102137
17116885
17582221
19793801
14988723
17384638
18931676
15459660
|
CSNK2A1
|
RANGAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
16428860
18669648
|
CSNK2A1
|
PIAS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24174529
19217413
|
CSNK2A1
|
MDC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
20711462
20507565
19118383
18411308
21576760
18678890
18583988
15066279
20471329
19230643
21592330
21118972
18006705
20533398
|
DCLRE1B
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21217703
18468965
20479256
26496610
16606622
18469862
16730175
|
DCLRE1B
|
MUS81
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18469862
|
RPA1
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17720710
12226657
18342608
20129063
|
MSH2
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
EME1
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
SLX4
|
ERCC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
23994477
24012755
21240275
24726326
22902628
23093618
19595721
19596235
25538220
20658648
19596236
19595722
|
FANCD2
|
XRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
FANCD2
|
XRCC3
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
FANCD2
|
SLX4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21464321
|
SQSTM1
|
KEAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
15340068
16252010
20531300
21981924
23850759
25002027
26587781
26653790
26794443
27048822
28574505
|
VCP
|
KEAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
33444648
11733065
28115426
15652483
10811609
29153394
|
SQSTM1
|
KEAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
34.0
|
1.0
|
Omnipath
|
20378532
35044719
20495340
25416956
25939382
23117207
32075457
20452972
24322982
20562859
25910212
26043024
33397898
23795962
27631370
33603948
20421418
32296183
23242280
19615732
31169361
20173742
24011591
21482715
|
SUMO3
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
22661230
25218447
24782567
22635276
|
MDC1
|
TP53BP1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
17303408
17660363
18001824
18006705
18087291
18583988
18590585
18678890
7575488
9407949
|
MDC1
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16009723
17145710
18087291
17925396
12607005
|
MDC1
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
17145710
15201865
20460517
23115235
14519663
18001824
18678890
19804756
18583988
19230643
12607003
12607005
20224574
|
MSH2
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
26.0
|
1.0
|
ACSN
|
11307145
11948476
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
16879101
17129768
17303408
17395641
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
23507534
|
MSH2
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MSH6
|
â—¼ SHARES_COMPLEX
|
|
|
26.0
|
1.0
|
ACSN
|
11307145
11948476
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
16879101
17129768
17303408
17395641
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
23507534
|
MSH2
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MUS81
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MUS81
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
NBN
|
PARP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
25642960
25789972
11440997
25643323
20483915
25642963
15135726
16012167
11340072
|
PARP1
|
SUMO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
19779455
25218447
23750026
24782567
|
PIAS1
|
SUMO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16524884
22578841
19217413
18806873
14609633
11583632
|
PLK1
|
PIN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
27618008
23633483
16118204
9499405
16713569
25070718
25766872
10037602
22926167
|
PLK1
|
RAN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20805321
16930555
|
PLK1
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
20126263
25607646
24703952
|
RANGAP1
|
RAN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
7744835
8146159
9219684
16189514
10394366
|
UBE2I
|
RANGAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
23395904
16194093
16713569
18691969
18538659
21988832
21098080
21139563
17036045
11853669
22194619
15931224
26496610
19549727
9497385
16732283
20501649
17353931
20719936
12924945
16820290
14578449
18706886
|
RPA1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
RPA1
|
TOPBP1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
RPA1
|
TOPBP1
|
â—¼ REGULATES
|
✅
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
UBE2I
|
SUMO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
21212807
25416956
16713569
18691969
17938407
11735126
25502805
15931224
26496610
16732283
24352468
17353931
18359863
10666456
21174150
8921390
9353268
12924945
21949651
32296183
16524884
17956732
18264111
12764129
10961991
14673145
19684601
17698038
16494873
31515488
23871147
17491593
|
TERF2
|
TERF2IP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
17145710
19651898
15316005
27214791
10888888
21217703
19287395
15383534
26496610
23086976
19164295
15100233
16880378
26450775
21829167
10850490
28082411
23307557
21044950
14565979
|
MDC1
|
TERF2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.08
|
1.07
|
PKG
|
28854368
|
ATM
|
ATM
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.25
|
2.25
|
PKG
|
28854368
|
MDC1
|
TSPYL1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
2.8
|
2.8
|
PKG
|
28854368
|
MDC1
|
MDC1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-3.38
|
3.37
|
PKG
|
28854368
|
MSH6
|
MSH2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.08
|
4.07
|
PKG
|
28854368
|
MSH2
|
MSH6
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-5.11
|
5.1
|
PKG
|
28854368
|
MSH6
|
MSH6
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-5.12
|
5.11
|
PKG
|
28854368
|
MSH2
|
MSH3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-5.7
|
5.69
|
PKG
|
28854368
|
NBN
|
NBN
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.31
|
6.3
|
PKG
|
28854368
|
MSH2
|
MSH2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.48
|
6.47
|
PKG
|
28854368
|
PARP1
|
PARP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-7.28
|
7.27
|
PKG
|
28854368
|
TP53BP1
|
TP53BP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-9.54
|
9.53
|
PKG
|
28854368
|