Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
RECQL4 FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19567405
BLM PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16864798 0601828103
XRCC3 BLM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
RAD51C BLM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
PLK1 CDC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21041660 1013557107
PLK1 CDC6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 21041660 1013557107
HERC2 CHEK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
HERC2 CHEK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
CHEK2 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
RAD54L EME1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19017809 0807016105
RAD51C EME1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
XRCC3 EME1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
FEN1 MUS81 â—¼   COLOCALIZATION 2.0 0.8 intact 22551069 8372920
HERC2 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
MEN1 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12837246
RAD51C MUS81 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
XRCC3 MUS81 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
PLK1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
WEE1 PLK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15070733 15037762
PLK1 TP53BP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 1000287 20126263
SUMO2 RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19956565 1000252
VIM RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAD51C SLX1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
RAD51C SLX4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
WRN RAD52 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216387 12750383
WRN RAD52 â—¼   COLOCALIZATION 2.0 0.8 intact 5216387 12750383
XRCC3 SLX1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
XRCC3 SLX4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24076221 24831703
VIM SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
TERF2 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 21824286 8202878
VIM TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VIM WEE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
WRN ECHDC3 â—¼   KO_DOWN_REGULATES ✅ - -0.81 0.8 PKG 28854368
DDB1 MUS81 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 27354282 24412650
RECQL5 MT1G â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
MUS81 RRP44 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MUS81 XPF â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HERC2 EME1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29426014 25476789
HERC2 LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29426014 25476789
SUMO2 WRN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19471022 16524884
MUS81 TAGLN2 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
RECQL5 CAV1 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
MUS81 PPDPF â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
PLK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31730000 25483079 29656893 24067368
BRCA1 TERF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 25184681 29656893 34112789
FBXL5 HERC2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30279242 24778179
ERCC4 RAD52 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
CHEK2 TP53BP1 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
FEN1 WRN â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
RAD52 TP53BP1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
MSH2 BLM â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15064730 10783165
SUMO2 BLM â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19471022 16524884 16620772 21693764
CDS1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12438214 16713569
RAD51 RAD51C â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MUS81 SDC2 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
SUMO2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21147198 20016594 20016603 22689573 21693764
RECQL4 ECHDC3 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
MSH2 LCP1 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
BRCA1 WRN â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
SLX4 MSH3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31495888 19596235
BRCA1 MSH2 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
ERCC4 MUS81 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
SLX1 PLK1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 32707033 19596235
SLX1 EME1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19595721 19596235
BRCA1 MSH3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 14578343 11498787
ERCC4 FEN1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RAD52 WRN â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FEN1 MSH2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BLM FEN1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RECQL5 LCP1 â—¼   KO_UP_REGULATES ✅ + 0.87 0.87 PKG 28854368
FANCM RAD52 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
BRCA1 CHEK2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
SLX1 XPF â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 19595721 19596236 19596235
SLX1 ERCC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28514442 19595721 19596235
SLX1 MUS81 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 19595721 19596236 19596235
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25084169 29656893 26831064 10783165
PLK1 WEE1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32707033 15070733 25659891
CHEK2 MUS81 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RAD51 RAD54L â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MUS81 ECHDC3 â—¼   KO_DOWN_REGULATES ✅ - -0.89 0.88 PKG 28854368
CHK2 MSH2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15647386 16189514 12447371
PLK1 XPF â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25659891 28514442 32707033 19596235
ATRX RAD51 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
DDB1 DCAF4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16964240 19966799 16949367 30945288 28514442
SLX4 EME1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31495888 32398829 19595721 19596236 19596235
WRN TERF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12181313 18212065
TP53BP1 PPDPF â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
BLM RAD52 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ERCC1 MUS81 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
CHK2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17525332 10724175 28430840 12049740 18804494 26121674 17380128 16713569 12438214 12111733
MUS81 CHK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11073977 11741546 16189514
PLK1 CHK2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11901158 10973490 20126263 12493754 16189514 12242661 12024051
SLX4 XPF â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 26453996 22902628 23093618 23623386 32398829 25538220 31495888 23033263 21240275 19595722 19596236 19595721 24012755 23994477 19596235
SLX4 SLX1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23093618 31495888 32398829 19595721 19596236 24012755 19596235
BLM TERF2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12181313 19329795 15229185
RAD51 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11498787 31270457 19369211 14636569 24085845 29656893 28319063 25659039 34408138 31009828 9774970 16713569 25499220 19766185 17302439 9008167 28976962
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
CHEK2 TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 26799419 19375317
SLX4 ERCC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22902628 23093618 23623386 31495888 25538220 32398829 23033263 21240275 26186194 19595721 19596236 28514442 19596235
ERCC1 ERCC5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
ERCC1 RAD51 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 14734547 17962301 18541667
ERCC1 RAD52 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 14734547 17962301 18541667
ERCC5 ERCC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
ERCC4 SLX4 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RAD51 ERCC4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 14734547 17962301 18541667
RAD52 ERCC4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 14734547 17962301 18541667
PLK1 FBXL5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SLX4 MSH2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22902628 31495888 32398829 19596235
SLX4 MUS81 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23033263 29850896 21240275 21516116 25533185 23994477 22902628 31495888 19596235 32296183 23093618 32398829 19596236 28514442 25416956 29892012 23623386 19595721 24012755 25224045
NR1I2 MUS81 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19129222
SLX4 PLK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25852190 22902628 31495888 25659891 32707033 19596235
RECQL5 NES â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
RECQL4 NES â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
ERCC1 SLX4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
FANCM MUS81 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
MUS81 HLA-A â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
MUS81 SLX4 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
RAD51C XRCC3 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
MUS81 LMNA â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
BLM XRCC3 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
FBXO18 RAD51 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
RECQL4 SERPINB9 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
BLM MUS81 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RECQL4 MT1G â—¼   KO_DOWN_REGULATES ✅ - -0.94 0.93 PKG 28854368
RAD52 TERF2 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
BLM TP53BP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DCAF4 DDB1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RAD54L CAV1 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
FANCM TAGLN â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
MSH3 MSH2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 16025128 8942985 22179786 22939629 8805365 14657349 9774676 10029069 19377479
RAD52 RAD51 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 28551686 9826763 20190268 12750383 17118963 9837724 10666456 15766559 19338310 10212258 8550550 10448035
DCLRE1B TERF2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SLX4 TERF2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
RECQL5 FLNC â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
DDB1 VPRBP â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
XPF ERCC1 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 17289582 19940136 22939629 14706347 26453996 23580445 26344197 25956741 31495888 25538220 14734547 15932882 16338413 8197175 9722633 24036546 26085086 10413517 22353549 17912758 21466675 9013642 28514442 11160918 24780295 16076955 26186194 21875596
BLM RAD51 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ERCC1 ERCC4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
BLM FANCM â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM FANCM â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM WRN â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
BLM TERF2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 23253856 24089143 24095737
BLM FEN1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
FANCM BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20347428 20064461
TERF2 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 15229185 19329795 12181313
BLM FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19772495 18931676 19847258 22266823 12356323 19622404 16326861 24089143 22973052 23253856 22657828 16697054 24095737 19686080 14688284
BRCA1 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
CHEK2 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
CHEK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 18566216 15810020 24492479 20860841 16713569 26383678 10724175 12049740 24986639 23388117 14701743 30327455 33397362 22921572 18804494 24348208 20364141 22941656 15459660 17464182 20952512 24069304 15485917 22193408 12111733 27170701
PLK1 CDC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21041660
PLK1 CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 12024051 24844881 18802408 19216791 10973490 18804494 12242661 20126263 16189514 11901158 12493754
DCLRE1B TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21217703 18468965 20479256 26496610 16606622 18469862 16730175
DCLRE1B MUS81 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18469862
MSH2 EME1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MUS81 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MSH3 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 EME1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MSH3 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
EME1 MUS81 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
POLM EME1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 15703371 16697054 16738138 17483519 17631059 19346677 19473888 19772495 19808869 19847258
SLX4 ERCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23994477 24012755 21240275 24726326 22902628 23093618 19595721 19596235 25538220 20658648 19596236 19595722
PLK1 FANCM â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
PLK1 FANCM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18931676 19270156 19622404 19680264 19686080
WRN FEN1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
WRN FEN1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
WRN FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 14657243 12356323 11598021 16326861 10893179 14688284
MSH2 MSH3 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 MUS81 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 MUS81 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 MSH3 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
POLM MSH2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 15703371 16697054 16738138 17483519 17631059 19346677 19473888 19772495 19808869 19847258
MUS81 MSH3 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MUS81 MSH3 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
POLM MSH3 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 15703371 16697054 16738138 17483519 17631059 19346677 19473888 19772495 19808869 19847258
POLM MUS81 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 15703371 16697054 16738138 17483519 17631059 19346677 19473888 19772495 19808869 19847258
RAD54L MUS81 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19017809
PLK1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
PLK1 WEE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 17145710 18931676 16085715 15350223 18285803 19270156 26899266 19489726 19622404 28415805 30067982 23051732 19686080 15070733
PLK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20126263 25607646 24703952
PLK1 VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 28390425 27603133 24196446 18056432 16260496 28953239
RAD51 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RECQL5 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20348101 22645136
RAD52 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15766559 17145710 9826763 20190268 17118963 10666456 12750383 9837724 19338310 10448035 10212258
XRCC3 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9660962 23438602 28864920 11842113
XRCC3 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
XRCC3 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
WRN RAD52 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12750383 12919958 17118963
WRN TERF2 â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11283614 12202749 12545156 15155580 15385537 16449207 17055429 17116323 17550342 17965729 18398454 18524993 18558713 18584027 18809224 19490890 20027199 20064462 20691907 20713526 20818389 21376743 21733352 2191300 21919891 22657828 22743550 23082994 23140366 23161013 23253856 23869868 24036544 24050180 24709898 9618481
TERF2 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 15665826 18212065 12181313
MUS81 LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.01 1.01 PKG 28854368
RECQL5 LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.02 1.02 PKG 28854368
RECQL4 VIM â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
RAD52 CDC6 â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
RECQL4 FLNC â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
RAD52 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
MUS81 TPM1 â—¼   KO_UP_REGULATES ✅ + 1.09 1.09 PKG 28854368
TP53BP1 LCP1 â—¼   KO_UP_REGULATES ✅ + 1.1 1.1 PKG 28854368
FANCM CAPN2 â—¼   KO_DOWN_REGULATES ✅ - -1.14 1.13 PKG 28854368
MUS81 HMGCS1 â—¼   KO_UP_REGULATES ✅ + 1.14 1.14 PKG 28854368
MUS81 FLNC â—¼   KO_UP_REGULATES ✅ + 1.15 1.15 PKG 28854368
POLM RPL22L1 â—¼   KO_DOWN_REGULATES ✅ - -1.2 1.19 PKG 28854368
MUS81 RPL22L1 â—¼   KO_UP_REGULATES ✅ + 1.19 1.19 PKG 28854368
TP53BP1 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.21 1.21 PKG 28854368
RECQL4 HMGCS1 â—¼   KO_DOWN_REGULATES ✅ - -1.22 1.22 PKG 28854368
RECQL5 TAGLN â—¼   KO_UP_REGULATES ✅ + 1.24 1.24 PKG 28854368
RECQL4 MT1H â—¼   KO_DOWN_REGULATES ✅ - -1.25 1.24 PKG 28854368
MUS81 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.25 1.25 PKG 28854368
RECQL5 VIM â—¼   KO_UP_REGULATES ✅ + 1.26 1.26 PKG 28854368
RECQL4 CDC6 â—¼   KO_DOWN_REGULATES ✅ - -1.27 1.26 PKG 28854368
RECQL4 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.28 1.27 PKG 28854368
MUS81 ANXA3 â—¼   KO_UP_REGULATES ✅ + 1.28 1.28 PKG 28854368
TP53BP1 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
MUS81 LGALS3BP â—¼   KO_UP_REGULATES ✅ + 1.31 1.31 PKG 28854368
MUS81 LCP1 â—¼   KO_UP_REGULATES ✅ + 1.33 1.33 PKG 28854368
MUS81 NES â—¼   KO_UP_REGULATES ✅ + 1.36 1.36 PKG 28854368
ERCC5 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
MUS81 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.4 1.4 PKG 28854368
WRN PPDPF â—¼   KO_UP_REGULATES ✅ + 1.42 1.42 PKG 28854368
RECQL4 CAV1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368
MUS81 CDC6 â—¼   KO_UP_REGULATES ✅ + 1.48 1.48 PKG 28854368
TP53BP1 SPP1 â—¼   KO_UP_REGULATES ✅ + 1.53 1.53 PKG 28854368
POLM CDC6 â—¼   KO_DOWN_REGULATES ✅ - -1.56 1.55 PKG 28854368
RECQL5 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.6 1.6 PKG 28854368
RECQL5 MT1E â—¼   KO_UP_REGULATES ✅ + 1.62 1.62 PKG 28854368
FANCM SERPINB9 â—¼   KO_DOWN_REGULATES ✅ - -1.64 1.63 PKG 28854368
RECQL4 ANXA3 â—¼   KO_DOWN_REGULATES ✅ - -1.69 1.68 PKG 28854368
ERCC5 ERCC5 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
RECQL4 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.71 1.71 PKG 28854368
MUS81 MT1H â—¼   KO_UP_REGULATES ✅ + 1.72 1.72 PKG 28854368
TP53BP1 FLNC â—¼   KO_UP_REGULATES ✅ + 1.72 1.72 PKG 28854368
RECQL4 LGALS3BP â—¼   KO_UP_REGULATES ✅ + 1.75 1.75 PKG 28854368
MUS81 CAPN2 â—¼   KO_UP_REGULATES ✅ + 1.82 1.82 PKG 28854368
RECQL4 ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -1.92 1.91 PKG 28854368
MUS81 VIM â—¼   KO_UP_REGULATES ✅ + 2.02 2.02 PKG 28854368
MUS81 MT1X â—¼   KO_UP_REGULATES ✅ + 2.06 2.06 PKG 28854368
WRN CDC6 â—¼   KO_UP_REGULATES ✅ + 2.2 2.2 PKG 28854368
MUS81 MT1E â—¼   KO_UP_REGULATES ✅ + 2.44 2.44 PKG 28854368
RECQL4 RECQL4 â—¼   KO_DOWN_REGULATES ✅ - -2.61 2.61 PKG 28854368
MUS81 SERPINB9 â—¼   KO_UP_REGULATES ✅ + 2.77 2.77 PKG 28854368
MUS81 TAGLN â—¼   KO_UP_REGULATES ✅ + 2.84 2.84 PKG 28854368
RECQL4 TAGLN â—¼   KO_DOWN_REGULATES ✅ - -3.05 3.04 PKG 28854368
RAD54L RAD54L â—¼   KO_DOWN_REGULATES ✅ - -3.32 3.31 PKG 28854368
MUS81 MT1G â—¼   KO_UP_REGULATES ✅ + 3.46 3.46 PKG 28854368
WRN WRN â—¼   KO_DOWN_REGULATES ✅ - -3.6 3.59 PKG 28854368
MUS81 SPP1 â—¼   KO_UP_REGULATES ✅ + 4.3 4.3 PKG 28854368
MSH2 MSH3 â—¼   KO_DOWN_REGULATES ✅ - -5.7 5.69 PKG 28854368
MSH2 MSH2 â—¼   KO_DOWN_REGULATES ✅ - -6.48 6.47 PKG 28854368
RECQL5 RECQL5 â—¼   KO_DOWN_REGULATES ✅ - -7.08 7.07 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368