NHEJ1
|
XRCC4
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
DCLRE1C
|
XRCC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16857680
|
PIAS4
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
SP4
|
KNTC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15781457
11438531
|
NHEJ1
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
XRCC6
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
XRCC5
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
RPL39
|
TMEM147
|
â—¼ PHYSICAL_INTERACTION
|
|
|
800.0
|
0.8
|
STRING
|
36370105
|
WASF1
|
SORBS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5213352
11130076
|
POLM
|
MCM8
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.81
|
0.8
|
PKG
|
28854368
|
POLM
|
HERC5
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.8
|
0.8
|
PKG
|
28854368
|
POLM
|
CHAC2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.81
|
0.8
|
PKG
|
28854368
|
POLM
|
IFIT5
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.81
|
0.8
|
PKG
|
28854368
|
XRCC4
|
NDUFA4
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.81
|
0.81
|
PKG
|
28854368
|
POLM
|
PSPH
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.81
|
0.81
|
PKG
|
28854368
|
XRCC4
|
CDCA7
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.81
|
0.81
|
PKG
|
28854368
|
POLM
|
DCLK1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.82
|
0.81
|
PKG
|
28854368
|
POLM
|
RCE1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.82
|
0.81
|
PKG
|
28854368
|
MSH2
|
MCM8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
26300262
|
XRCC6
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22863883
21075794
|
POLM
|
GRID2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
NHEJ1
|
TIMM13
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.82
|
0.82
|
PKG
|
28854368
|
POLM
|
SLC25A15
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
POLM
|
AES
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
MSH3
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HuRI
|
32296183
|
NHEJ1
|
SERF2
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.82
|
0.82
|
PKG
|
28854368
|
POLM
|
HACD2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
SOX2
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
35140242
21280222
23667531
|
POLM
|
TPRKB
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.84
|
0.83
|
PKG
|
28854368
|
POLM
|
TMPO
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.83
|
0.83
|
PKG
|
28854368
|
PCNA
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
11239001
24695737
12171929
|
POLM
|
CTSL
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.85
|
0.84
|
PKG
|
28854368
|
XRCC4
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
9430729
15194694
22939629
9259561
15520013
|
POLM
|
MINPP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.86
|
0.85
|
PKG
|
28854368
|
POLM
|
RPL39
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.86
|
0.85
|
PKG
|
28854368
|
POLM
|
PLTP
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.86
|
0.85
|
PKG
|
28854368
|
POLM
|
ASF1A
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.86
|
0.85
|
PKG
|
28854368
|
POLM
|
GSTT2B
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.85
|
0.85
|
PKG
|
28854368
|
POLM
|
PDPN
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.86
|
0.85
|
PKG
|
28854368
|
COX4I1
|
NDUFA4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
860.0
|
0.86
|
STRING
|
36370105
|
SOX2
|
FOXP4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
35140242
23667531
|
NHEJ1
|
PAIP2
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.86
|
0.86
|
PKG
|
28854368
|
PRKDC
|
XRCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
POLM
|
PDK1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.87
|
0.87
|
PKG
|
28854368
|
LIG4
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
LIG4
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
DCLRE1C
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
POLM
|
CBR3
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.87
|
0.87
|
PKG
|
28854368
|
POLM
|
FKBP14
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.87
|
0.87
|
PKG
|
28854368
|
POLM
|
SOX3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.89
|
0.88
|
PKG
|
28854368
|
POLM
|
HIST1H1T
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.88
|
0.88
|
PKG
|
28854368
|
POLM
|
ELOF1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.89
|
0.88
|
PKG
|
28854368
|
POLM
|
SUCLG2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.89
|
0.88
|
PKG
|
28854368
|
POLM
|
ABR
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.9
|
0.89
|
PKG
|
28854368
|
POLM
|
CENPE
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.89
|
0.89
|
PKG
|
28854368
|
XRCC4
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21070942
31548606
21768349
17567543
26774286
18064046
21349273
29997244
16439205
|
PDK1
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
XRCC5
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
26496610
22404984
15520013
21679440
26446488
26344197
17308091
15941674
28154079
16857680
20711232
19303849
20023628
15758953
20085707
10750018
10446239
33005030
9312071
28345663
12393188
|
XRCC6
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8422676
20711232
19303849
26175416
28345663
30585729
17308091
22939629
26496610
10750018
15941674
33005030
21969602
15520013
10064605
21575865
26446488
|
XRCC6
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
33961781
24981860
22939629
15367688
26496610
26774286
21172662
11196700
15520013
22863883
21679440
17159921
30021884
14681455
26446488
26344197
10207052
30585729
17308091
11493912
10757784
10219089
10984620
19118032
12145306
32296183
28035050
19177010
18809223
21454661
15910003
10783163
28514442
21070772
25574025
15023334
7699019
10750018
10446239
22451927
33005030
9488450
17283121
19906305
|
POLM
|
UBE2H
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.91
|
0.9
|
PKG
|
28854368
|
POLM
|
LAD1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.91
|
0.9
|
PKG
|
28854368
|
POLM
|
KHDRBS2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.91
|
0.9
|
PKG
|
28854368
|
POLM
|
KLC3
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.9
|
0.9
|
PKG
|
28854368
|
POLM
|
GPX4
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.9
|
0.9
|
PKG
|
28854368
|
POLM
|
ID1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.91
|
0.9
|
PKG
|
28854368
|
POLM
|
SP4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.91
|
0.9
|
PKG
|
28854368
|
MSH2
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
909.0
|
0.9
|
STRING
|
36370105
|
NHEJ1
|
SDC4
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.9
|
0.9
|
PKG
|
28854368
|
POLM
|
DPY30
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.91
|
0.91
|
PKG
|
28854368
|
POLM
|
NDUFA4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.92
|
0.91
|
PKG
|
28854368
|
POLM
|
GHDC
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.91
|
0.91
|
PKG
|
28854368
|
POLM
|
PTPRZ1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.92
|
0.91
|
PKG
|
28854368
|
POLM
|
NDUFAB1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.91
|
0.91
|
PKG
|
28854368
|
POLM
|
SH3GL3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.93
|
0.92
|
PKG
|
28854368
|
POLM
|
HNRNPA1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.92
|
0.92
|
PKG
|
28854368
|
XRCC5
|
XRCC6
|
â—¼ CORRELATES
|
|
+
|
0.92
|
0.92
|
CCLE
|
31978347
|
NHEJ1
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
ELOF1
|
POLR2C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
POLM
|
SCD
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.94
|
0.93
|
PKG
|
28854368
|
XRCC6
|
PRKDC
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.93
|
0.93
|
Signor
|
19133841
|
COX4I1
|
NDUFAB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.93
|
STRING
|
36370105
|
PCNA
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
8858149
16189514
12171929
15225546
|
PCNA
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
POLM
|
DCXR
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.94
|
0.94
|
PKG
|
28854368
|
POLM
|
UPF3A
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.95
|
0.94
|
PKG
|
28854368
|
POLM
|
MARCHF6
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.96
|
0.95
|
PKG
|
28854368
|
POLM
|
POLR2C
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.96
|
0.95
|
PKG
|
28854368
|
NHEJ1
|
PLBD1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.96
|
0.95
|
PKG
|
28854368
|
POLM
|
ERVH48-1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.95
|
0.95
|
PKG
|
28854368
|
XRCC5
|
XRCC6
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.96
|
0.96
|
mint
|
10783163
5212534
|
POLM
|
OLFML3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.97
|
0.96
|
PKG
|
28854368
|
POLM
|
APOL2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.97
|
0.96
|
PKG
|
28854368
|
MSH3
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
33961781
16025128
8942985
22179786
22939629
8805365
14657349
9774676
10029069
19377479
|
POLM
|
TMEM230
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.98
|
0.97
|
PKG
|
28854368
|
NHEJ1
|
XRCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
POLM
|
NEBL
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.98
|
0.97
|
PKG
|
28854368
|
PRKDC
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
PRKDC
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
POLM
|
HYPK
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.98
|
0.98
|
PKG
|
28854368
|
XRCC5
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LIG4
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
LIG4
|
XRCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
30.0
|
1.0
|
ACSN
|
11163244
12032095
12471202
15385968
15703371
16439205
16697054
17088286
17638872
18077224
19346677
19473888
19546231
196269035
19772495
19808869
19847258
20691907
21175350
21211721
21270334
21300785
21376743
22055391
22469522
22713970
22743550
23178593
24050180
9242410
|
LIG4
|
XRCC4
|
â—¼ SHARES_COMPLEX
|
|
|
30.0
|
1.0
|
ACSN
|
11163244
12032095
12471202
15385968
15703371
16439205
16697054
17088286
17638872
18077224
19346677
19473888
19546231
196269035
19772495
19808869
19847258
20691907
21175350
21211721
21270334
21300785
21376743
22055391
22469522
22713970
22743550
23178593
24050180
9242410
|
PRKDC
|
LIG4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
15194694
15941674
17570479
|
XRCC4
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC4
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
NHEJ1
|
XRCC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
22228831
21349273
18064046
21070942
17567543
29997244
16439205
21768349
|
XRCC5
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11955432
16600297
16093244
16914548
|
XRCC6
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11955432
16600297
16093244
16914548
|
DCLRE1C
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
DCLRE1C
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PRKDC
|
DCLRE1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
17242184
15723659
11955432
16600297
23163657
22529269
16874298
21641068
19423708
15936993
1660029
|
MSH2
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
EME1
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
EME1
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
POLM
|
EME1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
UBE2D2
|
HIF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
10878807
9891082
12101228
10535940
12538644
11454738
22286099
10973499
|
UBE2D1
|
HIF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
10878807
9891082
12101228
10535940
12538644
11454738
22286099
10973499
|
UBE2D3
|
HIF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
10878807
9891082
12101228
10535940
12538644
11454738
22286099
10973499
|
HIF1A
|
PDK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
66.0
|
1.0
|
ACSN
|
10102273
10428030
10428780
10435632
10804084
10823814
11557773
11559532
11744734
11756417
11884613
12402042
12676992
12743597
14672622
14684737
14699081
14762718
15024076
15059920
15199147
15240700
15312748
15369676
15379897
15545625
16110315
16126909
16127144
16517405
16517406
16585195
16782875
16888645
17143338
17418790
17533374
17785433
18054315
18056423
18158893
18718909
19211554
20028863
20427344
20535745
20855962
21051947
21765015
22006996
22841746
22850421
22988108
24006507
25043024
25103413
25732824
7493931
7500013
7508926
8089148
8702901
8955077
9486205
9525945
9707622
|
HIF1A
|
PDK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18269201
16517405
17855495
|
MSH2
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
POLM
|
MSH2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
MUS81
|
MSH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MUS81
|
MSH3
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
POLM
|
MSH3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
POLM
|
MUS81
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
NDUFA4
|
NDUFAB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
15186778
15526035
15807660
16200211
16218961
17344420
18485875
19131594
20025615
20816094
|
NDUFA4
|
NDUFAB1
|
â—¼ SHARES_COMPLEX
|
|
|
10.0
|
1.0
|
ACSN
|
15186778
15526035
15807660
16200211
16218961
17344420
18485875
19131594
20025615
20816094
|
XRCC5
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PRKDC
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC6
|
NHEJ1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
NHEJ1
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC6
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC5
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PRKDC
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
POLM
|
SMCR8
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.01
|
1.0
|
PKG
|
28854368
|
POLM
|
TST
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.01
|
1.01
|
PKG
|
28854368
|
POLM
|
B4GAT1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.01
|
1.01
|
PKG
|
28854368
|
POLM
|
WASF1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.02
|
1.01
|
PKG
|
28854368
|
POLM
|
TMEM147
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.03
|
1.02
|
PKG
|
28854368
|
POLM
|
NOP10
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.02
|
1.02
|
PKG
|
28854368
|
POLM
|
KNSTRN
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.04
|
1.03
|
PKG
|
28854368
|
POLM
|
SDC4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.04
|
1.03
|
PKG
|
28854368
|
POLM
|
DCBLD2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.04
|
1.03
|
PKG
|
28854368
|
POLM
|
TCEAL2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.05
|
1.04
|
PKG
|
28854368
|
POLM
|
NODAL
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.04
|
1.04
|
PKG
|
28854368
|
POLM
|
SNX21
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.05
|
1.04
|
PKG
|
28854368
|
POLM
|
AASS
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.06
|
1.05
|
PKG
|
28854368
|
POLM
|
TIMM13
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.06
|
1.05
|
PKG
|
28854368
|
POLM
|
BNC2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.07
|
1.06
|
PKG
|
28854368
|
POLM
|
DDRGK1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.08
|
1.07
|
PKG
|
28854368
|
NHEJ1
|
NIPSNAP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.08
|
1.07
|
PKG
|
28854368
|
POLM
|
LIN28A
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.08
|
1.08
|
PKG
|
28854368
|
POLM
|
PRDX4
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.08
|
1.08
|
PKG
|
28854368
|
POLM
|
TCF25
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.09
|
1.08
|
PKG
|
28854368
|
POLM
|
ZNF121
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.09
|
1.08
|
PKG
|
28854368
|
POLM
|
SKA3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.09
|
1.08
|
PKG
|
28854368
|
POLM
|
KNTC1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.09
|
1.08
|
PKG
|
28854368
|
NHEJ1
|
NDUFA4
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.1
|
1.1
|
PKG
|
28854368
|
POLM
|
NIPSNAP1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.11
|
1.11
|
PKG
|
28854368
|
POLM
|
SORBS2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.12
|
1.11
|
PKG
|
28854368
|
POLM
|
TACO1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.11
|
1.11
|
PKG
|
28854368
|
XRCC4
|
TCF25
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.12
|
1.12
|
PKG
|
28854368
|
NHEJ1
|
NODAL
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.12
|
1.12
|
PKG
|
28854368
|
NHEJ1
|
NEBL
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.13
|
1.13
|
PKG
|
28854368
|
PRKDC
|
RPL22L1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.15
|
1.15
|
PKG
|
28854368
|
POLM
|
PAIP2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.16
|
1.15
|
PKG
|
28854368
|
XRCC4
|
SCD
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.16
|
1.16
|
PKG
|
28854368
|
POLM
|
TENM3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.17
|
1.16
|
PKG
|
28854368
|
XRCC4
|
RPL22L1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.17
|
1.17
|
PKG
|
28854368
|
POLM
|
G2E3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.18
|
1.17
|
PKG
|
28854368
|
POLM
|
CCDC28A
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.18
|
1.17
|
PKG
|
28854368
|
POLM
|
ZDHHC22
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.19
|
1.18
|
PKG
|
28854368
|
NHEJ1
|
ERVH48-1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.19
|
1.18
|
PKG
|
28854368
|
POLM
|
LIN7A
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.19
|
1.18
|
PKG
|
28854368
|
POLM
|
POLE2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.19
|
1.18
|
PKG
|
28854368
|
POLM
|
RPL22L1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.2
|
1.19
|
PKG
|
28854368
|
MUS81
|
RPL22L1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.19
|
1.19
|
PKG
|
28854368
|
POLM
|
GOLM1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.21
|
1.2
|
PKG
|
28854368
|
POLM
|
FHL2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.22
|
1.21
|
PKG
|
28854368
|
POLM
|
PTBP3
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.22
|
1.22
|
PKG
|
28854368
|
NHEJ1
|
RIPOR2
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.22
|
1.22
|
PKG
|
28854368
|
XRCC4
|
CBR3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.23
|
1.22
|
PKG
|
28854368
|
POLM
|
SLC1A3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.25
|
1.24
|
PKG
|
28854368
|
POLM
|
FOXP4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.26
|
1.25
|
PKG
|
28854368
|
PRKDC
|
SORBS2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.27
|
1.26
|
PKG
|
28854368
|
POLM
|
ZNF627
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.3
|
1.29
|
PKG
|
28854368
|
POLM
|
ZNF770
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.31
|
1.3
|
PKG
|
28854368
|
POLM
|
FSTL1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.32
|
1.31
|
PKG
|
28854368
|
POLM
|
PLBD1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.32
|
1.32
|
PKG
|
28854368
|
XRCC4
|
MORF4L2
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.32
|
1.32
|
PKG
|
28854368
|
POLM
|
SERF2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.35
|
1.34
|
PKG
|
28854368
|
POLM
|
COX4I1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.35
|
1.35
|
PKG
|
28854368
|
POLM
|
CGAS
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.36
|
1.36
|
PKG
|
28854368
|
POLM
|
TMEFF1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.37
|
1.36
|
PKG
|
28854368
|
POLM
|
AGA
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.38
|
1.37
|
PKG
|
28854368
|
POLM
|
DHFR
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.39
|
1.38
|
PKG
|
28854368
|
POLM
|
UBLCP1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.39
|
1.38
|
PKG
|
28854368
|
XRCC4
|
PLBD1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.4
|
1.39
|
PKG
|
28854368
|
POLM
|
MORF4L2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.41
|
1.4
|
PKG
|
28854368
|
POLM
|
CDCA7
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.43
|
1.42
|
PKG
|
28854368
|
POLM
|
HNRNPUL2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.44
|
1.43
|
PKG
|
28854368
|
POLM
|
RAVER1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.44
|
1.44
|
PKG
|
28854368
|
MUS81
|
CDC6
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.48
|
1.48
|
PKG
|
28854368
|
POLM
|
FAM76A
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.5
|
1.5
|
PKG
|
28854368
|
XRCC4
|
LIG4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.52
|
1.51
|
PKG
|
28854368
|
POLM
|
CTSV
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.52
|
1.51
|
PKG
|
28854368
|
XRCC4
|
CCDC28A
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.55
|
1.54
|
PKG
|
28854368
|
POLM
|
C20orf27
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.55
|
1.55
|
PKG
|
28854368
|
POLM
|
CDC6
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.56
|
1.55
|
PKG
|
28854368
|
NHEJ1
|
C20orf27
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.56
|
1.55
|
PKG
|
28854368
|
NHEJ1
|
TMEM230
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.56
|
1.55
|
PKG
|
28854368
|
POLM
|
SHTN1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.6
|
1.59
|
PKG
|
28854368
|
POLM
|
RIPOR2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.65
|
1.64
|
PKG
|
28854368
|
NHEJ1
|
PCNA
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.66
|
1.65
|
PKG
|
28854368
|
NHEJ1
|
CDC6
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.68
|
1.68
|
PKG
|
28854368
|
POLM
|
ZNF691
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.69
|
1.69
|
PKG
|
28854368
|
POLM
|
CCDC120
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.86
|
1.85
|
PKG
|
28854368
|
POLM
|
PIAS4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.88
|
1.87
|
PKG
|
28854368
|
XRCC4
|
CDC6
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
2.56
|
2.56
|
PKG
|
28854368
|
NHEJ1
|
UBE2C
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
2.74
|
2.74
|
PKG
|
28854368
|
POLM
|
C10orf88
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-2.76
|
2.75
|
PKG
|
28854368
|
POLM
|
MTMR3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-3.18
|
3.17
|
PKG
|
28854368
|
PRKDC
|
PRKDC
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.22
|
4.21
|
PKG
|
28854368
|
POLM
|
SENP6
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
4.37
|
4.37
|
PKG
|
28854368
|
MSH2
|
MSH3
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-5.7
|
5.69
|
PKG
|
28854368
|
XRCC4
|
XRCC4
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.32
|
6.31
|
PKG
|
28854368
|
NHEJ1
|
NHEJ1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.47
|
6.46
|
PKG
|
28854368
|
MSH2
|
MSH2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.48
|
6.47
|
PKG
|
28854368
|