HSPA5
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
CDC37
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TIMM8A
|
ADRM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16990800
5219132
|
TIMM13
|
ADRM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16990800
5219132
|
RYBP
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
24981860
|
YWHAZ
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
COX4I1
|
KLF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
EZR
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
SMARCB1
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HNRNPH2
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
HTRA2
|
RYBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
KSR1
|
YWHAZ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9115393
9858547
|
LRRK2
|
LATS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29513927
201700444
|
LRRK2
|
RPS6KB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29513927
201700444
|
RYBP
|
SOD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
COX4I1
|
NDUFA8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
801.0
|
0.8
|
STRING
|
36370105
|
COX4I1
|
NDUFS8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
805.0
|
0.8
|
STRING
|
36370105
|
AURKAIP1
|
MRPL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
815.0
|
0.81
|
STRING
|
36370105
|
AURKAIP1
|
MRPL50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
815.0
|
0.81
|
STRING
|
36370105
|
CDT1
|
CUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30018425
12840033
|
CUL1
|
MATR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
29884807
21145461
|
LRRK2
|
ADRM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31046837
24947832
|
LRRK2
|
AIFM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31046837
24725412
|
AIFM1
|
SFXN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
27218139
|
PCGF6
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
12167161
24981860
|
BMI1
|
RNPS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34316702
24457600
|
HDAC1
|
PRDM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19124609
22733990
|
HTRA2
|
LATS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17130845
16007220
22641346
|
LRRK2
|
SFXN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31046837
24725412
|
NHEJ1
|
TIMM13
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.82
|
0.82
|
PKG
|
28854368
|
TIMM10
|
TIMM8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
CUL1
|
CUL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
CUL3
|
CUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26344197
21145461
|
KLF11
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16713569
11438660
|
RNPS1
|
HTRA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31617661
17353931
|
LRRK2
|
PSMD6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
31046837
24725412
|
LRRK2
|
CDC37
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
16321986
20642453
22612223
23075850
26355680
18367605
|
PCGF6
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33961781
28514442
22325352
27705803
|
POLM
|
PDK1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.87
|
0.87
|
PKG
|
28854368
|
CDC37
|
LRRK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
NDUFA8
|
NDUFS8
|
â—¼ CORRELATES
|
|
+
|
0.88
|
0.88
|
CCLE
|
31978347
|
DNM1L
|
LRRK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
TIMM10
|
TIMM9
|
â—¼ CORRELATES
|
|
+
|
0.88
|
0.88
|
CCLE
|
31978347
|
BMI1
|
RYBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
CAND1
|
CUL1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
12504025
12504026
15537541
|
CUL3
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21145461
21249194
22013077
16449638
22405651
26286618
12609982
|
CUL3
|
HDAC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
ACSN
|
15467454
15688063
17312394
|
LRRK2
|
DNM1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24282027
22228096
22639965
23813973
29541021
|
MRPL3
|
MRPL50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
907.0
|
0.9
|
STRING
|
36370105
|
LRRK2
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
NDUFA8
|
NDUFAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
CAND1
|
CUL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
CAND1
|
CUL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
TIMM13
|
TIMM8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
940.0
|
0.94
|
STRING
|
36370105
|
CDC34
|
CUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
CUL1
|
CAND1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
17290223
5219620
|
TIMM10
|
TIMM13
|
â—¼ PHYSICAL_INTERACTION
|
|
|
964.0
|
0.96
|
STRING
|
36370105
|
TIMM13
|
TIMM9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
964.0
|
0.96
|
STRING
|
36370105
|
ADRM1
|
PSMD6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
TIMM13
|
TIMM8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
NDUFAF3
|
NDUFS8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
NDUFA8
|
NDUFS8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
CAND1
|
CUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
TIMM10
|
TIMM9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
CUL1
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9346238
15340381
16303288
8706131
|
CAND1
|
CUL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
45.0
|
1.0
|
Omnipath
|
17145710
12684064
25435324
36076154
23019411
18826954
17290223
17438373
21169563
27542266
16036220
21145461
21778237
22474075
22767593
16861300
18173839
12504026
12504025
12706828
22405651
21249194
23453757
22013077
17439941
12609982
15537541
|
AIFM1
|
NDUFA8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
AIFM1
|
NDUFS8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
AIFM1
|
NDUFA8
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
AIFM1
|
NDUFS8
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
AIFM1
|
NDUFS8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
AIFM1
|
NDUFA8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
15526035
16200211
16218961
16489074
17344420
20025615
20816094
24684389
|
BCKDK
|
DLD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
22956686
15166214
24449431
15576032
|
HDAC1
|
BMI1
|
â—¼ UP_REGULATES
|
✅
|
+
|
22.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
15151915
15155580
15465827
16232121
17055429
17508028
17550342
20027199
20713526
20818389
21234400
21733352
2191300
21919891
22370643
22796940
23140366
23869868
9618481
|
CAB39
|
STRADA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
CAB39
|
STRADA
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
RPA3
|
CDT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA3
|
CDT1
|
â—¼ SHARES_COMPLEX
|
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
RPA3
|
CDT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
11900249
12648680
14624239
15459660
15703371
16697054
17102137
17116885
17296725
17582221
17884153
18677104
19793801
19809470
19847258
|
DLD
|
PDK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
7499431
11485553
9405293
8798399
11486000
|
HDAC1
|
TCF7L2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
10485845
11266540
10559189
20405012
|
NDUFS8
|
NDUFA8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
15186778
15526035
15807660
16200211
16218961
17344420
18485875
19131594
20025615
20816094
|
NDUFS8
|
NDUFA8
|
â—¼ SHARES_COMPLEX
|
|
|
10.0
|
1.0
|
ACSN
|
15186778
15526035
15807660
16200211
16218961
17344420
18485875
19131594
20025615
20816094
|
NDUFS8
|
NDUFA8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15186778
15526035
15807660
16200211
16218961
17344420
18485875
19131594
20025615
20816094
|
NHEJ1
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
RAD51
|
XRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
RAD51
|
XRCC3
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
XRCC3
|
RAD51
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9660962
23438602
28864920
11842113
|
POLM
|
TIMM13
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.06
|
1.05
|
PKG
|
28854368
|
POLM
|
COX4I1
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
1.35
|
1.35
|
PKG
|
28854368
|
NHEJ1
|
NHEJ1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-6.47
|
6.46
|
PKG
|
28854368
|