Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
DDIT4 TSC2 â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 18198340 19557001
DDIT4 TSC1 â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 18198340 19557001
TP53 DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400 19210572
TP53 DDIT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
ELAVL1 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19114552
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19050291 19745063
FOXO1 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16997836 24478438
FOXO1 ADIPOR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21194380 20125105
FOXO1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22968147 21335550
FOXO1 RPS6KA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12351634
FOXO1 PCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11467835
FOXO1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19676152
FOXO1 PCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17627282
PPP2R1A FOXO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20110348 8288835
FOXO3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056725 21752881
FOXO3 TSC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20371605
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
PRKAB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21329882 17711846
FOXO3 G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16840535
RAB11B GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DVL2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PPP2CB GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
LPIN1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP2R1A GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
PIK3CA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRB10 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
GRB2 EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 LEPR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRB2 SHMT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
MAPK1 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
MAPK1 PPP2R5C â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16456541 5218298
RPS6KA1 MAPK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
PRKCB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8903320 10327068
MAPK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MAPK3 PPP2R5C â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16456541 17200115
MAPK3 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 SOS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK3 IRS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK3 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
PRKCB MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8903320 10327068
MAPK3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MTOR AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
SGK1 MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20338997 18925875
EIF4E MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12150926 15809305
AKT1 MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17611497 18954143
MTOR EIF4EBP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12150926 15809305
MTOR RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15060135
MTOR CLIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12231510
PIK3R1 SOS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23617393 8427684
PIK3R1 INSR â—¼   PROXIMITY 2.0 0.8 intact 6731120 10500481
TP53 PPP2R5C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PPP2R5C PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456541 5218298
PPP2R5C PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PPP2R5C CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8386317 8195196
RRAGD RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20006481 18497260
RSL1D1 FGB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SGK1 CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15733869 5217559
CREB1 SGK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733869 5217559
INS SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28106162 22842983
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
STK11 MOB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
STRADA CAB39L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14517248 12805220
STRADB CAB39L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14517248 12805220
HNF4A TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20621834 16771709
CREB1 TNF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084670
TNF CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21887257 19287455
TNF PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22078880 20651683
TNFRSF1A PFKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP2R2A TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
TP53 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TP53 PRKAA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
TP53 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12392301 22242153
TP53 PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10614633 9895308
IKBKB TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19196987 0812256106
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
PIK3R3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32606738
TP53 SCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
FZD7 WNT5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20457807 24865425
PPARGC1A PRKAA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17609368 0705070104
PRKAA2 PRKAG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16943194 8549768
PRKAA2 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
CREB1 ADIPOQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23568554 19932681
ATP6V1G1 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TSC2 TSC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6547838 9580671
RPS6KA2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15342917
TSC2 MAPKAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18411301 29497474
RICTOR PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18566587 6948588
MAP3K7 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219785 17363973
PPP2CA EIF4E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20927323 8288108
PPP2CA EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20927323
PTEN AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10644997
HRAS DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9069260 21779497
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
FZD2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23151663 19388021
FZD3 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22944199 19388021
PRKAG1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23217713
RHEB CREB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CHUK IKBKB â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CHUK IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12351658
PPARG CYP1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18308446 15521013
PPARG CD36 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20592862
EIF4B RPS6KA1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218723 16763566
DVL2 RHOA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11779461 18162551
RHOA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15884057 11748077
GOLGA2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
DVL2 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TSC1 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
TBC1D7 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17658474
GSK3B TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15972957 16959574
AKT2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150915 12172553
AKT3 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12150915 12172553
INS IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9609109 15316008
IRS1 LEPR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
IRS1 LEP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
IRS1 IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11912194
IGF1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19183465 12875741
IGF1 INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23518924 32196115
BRAF PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
PRKCA RPS6KA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
CREB1 ADRA1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10520459
CREB1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10909971 22554507
SOS1 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
PIK3CD IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LEPR IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
LEP IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
INS IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9609109 15316008
SREBF1 IRS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15881188 16091421
INSR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8567177 8385099
INS GRB10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12493740 14615605
PIK3CA GRB10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31066629 23246379
RAB2A GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GOLGA2 ATP6V1C2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
PPP2R1A EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R1B EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
SHMT2 CREB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
PPP2R5E PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R2A PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R5A PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
PPP2R5D PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R5A PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PPP2R1A MOB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
PPP2R2A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1328247 19114990
PPP2R5A PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8287037 7592815
PPP2CA EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16899564 16109716
LAMTOR2 ATP6V1B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 25567906 1257132
RPS6KB2 RPS6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16810323 5218785
RPS6KA2 RPS6 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16810323 5218785
RPS6KA3 RPS6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17360704
PIK3CD PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PIK3CA PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
RPS6KA2 BRAF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16810323 5218785
RRAGC RRAGA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RRAGA RNF152 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21203937 25936802
PIK3CD PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9885561 10455108
PRKAB1 PRKAA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6767403 18480843
PRKAB1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460634 21072212
PRKAB1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PIK3R2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 9651378
ATP6V1G2 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
EEF2K RPS6KA1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 11500364 5214384
WNT5B FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26849959 20093360
PRKAG1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PRKAG2 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
PRKAG3 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16326698 9029219
RPS6KB2 EEF2K â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 11500364 5214384
SREBF1 CIDEA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20575761 20542418
WNT4 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 14671310
WNT5A FZD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19910923 19582886
WNT2 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24032637
SREBF1 PIK3R3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17452746
SREBF1 ACACB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12764144
WNT5B FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
WNT11 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
RPS6 RSL1D1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
SOS2 HRAS â—¼   GTPASE_REACTION ✅ + 0.8 0.8 Signor 21779497
TBC1D7 TSC2 â—¼   PHYSICAL_INTERACTION 802.0 0.8 STRING 36370105
MLST8 RRAGC â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MLST8 RRAGA â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CAB39L STK11 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ATP6V1B1 ATP6V1H â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
FOXO3 TP53 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
IRS1 RPTOR â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16354680 19561084 30240640
EIF4E1B EIF4EBP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
CCNA1 SKP2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16774918 19270695 17308064 10652300
PPP2CB PPP2R5A â—¼   PHYSICAL_INTERACTION 809.0 0.81 STRING 36370105
NRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 34591642
NRAS BRAF â—¼   PROXIMITY ✅ 0.81 0.81 mint 30194290
SEH1L WDR59 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
BRAF RPTOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
SKP2 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19270695 21358672 23911321 19270694
SKP2 WDR59 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WDR59 GRB10 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WDR59 NPRL3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25263562 28199306
WNT7A WNT5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT7A WNT7B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT16 WNT5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT5A WNT5B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LPIN3 LPIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LPIN3 LPIN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT16 WNT11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
PPP2R1A PPP2R3A â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
TSC2 MTOR â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 12271141
CAB39 MED7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
CAB39L STRADA â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
SOS1 KRAS â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 25624485
PRR5L MTOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17461779 18030348
TTI1 MTOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20810650 22544753 20427287
MTOR SGK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18570873 27451907
TSC1 RHEB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12820960 30514904
SEC13 WDR59 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 25263562 28199306 33961781 26186194
CCNA2 CCNA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WNT4 WNT5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WNT4 WNT7B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WNT3A WNT3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MAPK3 RPS6KA2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
RHEB TSC1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
RPTOR ULK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FOXO1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
MTOR RPS6KB2 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 11733037
ULK1 RPTOR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25686248 21795849 21460634 21460630
AKT1 STK11 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
AKT1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
FZD8 WNT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CCNA1 SKP2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
MTOR ULK1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 21460634
RAB11B RAB8A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ATP6V1D ATP6V1G2 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NPRL3 RRAGC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RHEB MTOR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18550814 16098514 16915281 15854902 33157014 15772076 15878852 25351248
RPTOR RRAGA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 18497260 31601708 23184942 21816923 26582740 33961781 26186194 31601764 33157014 25561175 24337580
FZD8 WNT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15454084 11448771
PIK3CA IRS1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591642
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
CFTR IPO5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 31324722 29924966 17110338
MTOR SGK1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 18570873
PPP2R1B PPP2R2B â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
PTEN TP53 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
AKT1 PTEN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
AKT1 FOXO1 â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 21798082
AKT1 FOXO1 â—¼   RELOCALIZATION ✅ - 0.85 0.85 Signor 18423396
RPTOR RRAGD â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
TSC2 CCND1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16357142 26977878
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
IRS4 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21706016 9553137
PRR5 MTOR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17461779 18505677
MTOR MAPKAP1 â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 21045808 8088164
RPTOR TELO2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24036451 23263282
RPTOR RRAGC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25567906 21981924 18497260 31601708 21816923 25446900 31601764 25561175 24337580
TSC2 GSK3B â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16959574 12511557
AKT1 PTEN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12297295 19903340 12077256 28628118 20605778 28205554 10866658 20596030
INSR IGF1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26027733 8452530
AKT1 BRAF â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10869359 25241761 28628118 28205554
MAPK3 RPS6KA3 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
MTOR TTI1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
EIF4EBP1 MLST8 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
FNIP1 FNIP2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27353360 18403135
HNF4A FOXO1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12519792 19740748
ULK1 MTOR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25686248 23524951 29321306 21460630
TELO2 MTOR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18160036 20801936
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
GRB10 IRS1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8621530 12783867
CREB1 CRTC2 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PPP2CB PPP2R5C â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MAP3K7 TNFRSF1A â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CHUK MAP3K7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
DEPDC5 MIOS â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PFKL PFKM â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MTOR TELO2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PFKM PFKP â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 FOXO3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21621563 10102273 25241761 21775285
RRAGD RPTOR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26582740 24337580 18497260 22424946
TSC1 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28628118 15342917 12167664 28205554
PPP2R2A PPP2R2D â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
RAB10 RAB8A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17353931 26344197
AKT1 PIK3CA â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PRKAA1 PRKAG3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ATP6V1B1 ATP6V1B2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PPP2R1B PPP2R2D â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CHUK TNFRSF1A â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
HNF4A PPARGC1A â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GRB10 INSR â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
PPP2CA PPP2R2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
AKT1 PPP2CA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AKT1 FOXO1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RPTOR RRAGB â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
ATP6V1E2 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
AKT1 TSC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12438239 12150915 15342917 12167664
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
DVL2 DVL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 31340145 33961781 28514442
INSR IRS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8662806 8626379 9195949
PPP2R1A CFTR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
CFTR PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217765 15936019
INS INSR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 2550426 11278498 29512653 23302862
PPP2R1B PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8392071 8286818
RRAGA RRAGD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16189514 26582740 33961781 26186194 28716898 11073942 25561175 22424946
PRKAG1 PRKAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 18480843 6767403
IRS1 PIK3R2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
RAD51 TP53 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MIOS WDR59 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
AKT1 RICTOR â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
INSR PIK3R1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
IKBKB TNFRSF1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
IKBKB MAP3K7 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
MIOS SEC13 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CAB39 STK11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 19513107 25241761 26479318 14676191 15561763 20562859 31217475 31554794 33961781 15733851 25852190 32707033
FOXO1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22266855 12391153
FOXO3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12391153 21294163
FOXO1 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16670091 12414908 17317207
FOXO1 PCK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10385407
FOXO3 PRKAA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24257750 22848740 17711846
FOXO3 PIK3CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19299143 18644865
MAPK3 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19282669
PIK3CD GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
FGB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
PIK3CB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
IRS4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9553137 15316024
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
PPP2CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
SGK1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19447520
RHOA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15851026 17671177
BRAF MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
RPS6KA6 MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BRAF MAPK3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
PPP2CA MAPK3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK3 PPP2R5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16456541
MAPK3 STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25846811
MTOR GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MTOR RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16847060 26522726 12604610 19619545 26348909 33378666 20169205 24036451 18570873 24516643 19299511 34031390 22424946 22356909 25940091 12719976 22544753 23263282 12150926 12665511 18505677 17277771 17461779 22493283 19114562 18722121 21071439 18030348 19446321 12718876 12747827 24375676 22258093 16837165 21045808 16962653 18955708 17565979 12408816 15467718 23953116 27043084 23911927 17043309 31601708 21177249 21614075 21795849 16631613 20381137 21321085 23297343 23872070 16354680 19875983 25446900 29059166 24337580 16603397 16183647 34171383 15066126 24403073 25332233 17386266 19145465 25007995 16798736 26678875 15268862 20427287 30865892 16919458 25273559 15459249 18519641 18504440 12150925
MTOR AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 18566587 25792870 15718470 14970221 24670654 10910062 18505677 29567957 22337773 21177249 26293922 19299511 18566586 30639242 21045808 11438723 22084251 23872070 21343617 22307628
PRKCA MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21474067 18851840 20027184
PRKAA1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14970221
IRS4 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18165436 11912194
AKT1 PPP2R5C â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 1325671 17200115 19576174
RPS6KA6 FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RHEB RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16631613 25446900 15854902 33157014 24337580
RPS6KA3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722121
AKT2 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17517883 18372248 17277771
TTI1 TELO2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20427287 20371770 20801936 22863883 20810650
PPARG TNF â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 10432118 17681149 23390297
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
TP53 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15059920 27692180
TP53 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17530187 15456866
TP53 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17409411 18431400
TP53 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17409411 18431400
GSK3B PFKFB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CUL2 VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 22086907 28514442 9751722 10823831 15060148 11865071 21942715 27697924 20049704 26743088 11779168 17439941 12604794 9122164 21145461 15611064 19030229 21685897 12048197 10421634 28775317 15601820 10449727 24469044 11384984 10587522 18173839 22286099 17339318 16261165 16611863 23401859 15966899 22234250 9447969 17353931 26751167 18323857 25661653 33137104 11024059 18187417 18523483 10318914 26735018 24981860 33961781 31444342 26846855 17132228
WNT7A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19497282 22944199 23290138
FZD7 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14636582 22179044 19388021
PRKAA2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21673972
PRKAA2 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21459323
ADIPOQ ADIPOR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 26578976 12878598 12802337
ADIPOQ ADIPOR2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 26578976 12878598 12802337
SREBF1 ADIPOQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18669923 15037635 19932681
RHEB TSC2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12869586 12820960 30514904 12842888 17077083 15854902 12771962
AKT3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12150915 12167664 12172553
PPP2CA MAP3K7 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 608155200 17079228 8204431
PTEN CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21385900
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
PPP2CA CHUK â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8209688 506093200 16126728
AKT3 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19609947
PRKCB CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12070292
PPARG IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18394717 20064783 20685873
PPARG LIPE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16269451 17134676
SKP2 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9858587 26496610 27720894 33422522 16209941 33961781 24632684 15355997 26186194 7553852 31181401 20160477 10559858 33989513 18604603
CCNA2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9858587 15355997 33989513
SKP2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9858587 15355997 33989513
PRKCA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 11284700
WNT2 FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24032637
MAP2K1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11160134
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
AKT1 TBC1D1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17995453 17274760
PPP2CA PRKCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10592173 9675027
PRKCA BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1386920 16810323 12917261
PRKCA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
PRKCB IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12070292
CREB1 LEP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20484458 18787032 23056265
CRTC2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26652733 20730097
IRS2 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9113989
PPP2R1A PPP2CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15936019 16039140
PIK3CA SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
AKT2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10869359
PRKCB BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1386920 17570479 12917261
EIF4EBP1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22778263
PRKAA1 ACACB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12488245 12068056
DVL3 PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PIK3CB SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
PIK3R2 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22402981 8596638 11733063
PIK3R2 SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21653832 16456001 10068651
SOS1 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25624485 23331499 16293107
SREBF1 HMGCR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9651391 18413311
FGB PIK3R3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
WNT9B FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30978219 25892522 28733458
WNT3A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21078818 18212053 10601008
SREBF1 SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16787385 22735681
WNT10B FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11092808 12055200
MAPK1 RPS6KA3 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CCNA2 SKP2 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PRKAA2 PRKAB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
AKT1 MTOR â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
MAPK1 RPS6KA2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
MTOR AKT1S1 â—¼   PHOSPHORYLATION ✅ - 0.9 0.9 Signor 18372248
TSC1 RHEB â—¼   PHYSICAL_INTERACTION ✅ - 0.9 0.9 Signor 20006481
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PPP2R2A PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 20711181 8288198
FBP1 FBP2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
LAMTOR1 MTOR â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
LAMTOR4 MTOR â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGA RRAGB â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGD SLC38A9 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
IRS1 PIK3R3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
PPP2CB PPP2R2B â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATP6V1C2 ATP6V1D â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
TSC2 RHEB â—¼   GTPASE_REACTION ✅ - 0.91 0.91 Signor 15340059
LAMTOR4 RRAGD â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
PRKAB1 PRKAG3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
INSR IRS1 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 7651388
PIK3R1 IRS1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 6731578 14632132
PPP2R1A PPP2CB â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5217765 15936019
ATP6V1A RRAGC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ATP6V1B2 RRAGC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
LEPR LEP â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 22405007 9786864 33961781 8608603
IRS2 PIK3R1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
IRS1 PIK3CA â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V1B1 ATP6V1C1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V1A RRAGA â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ATP6V1B2 LAMTOR1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
MTOR AKT1 â—¼   PHOSPHORYLATION ✅ + 0.92 0.92 Signor 21592956
INSR IRS1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
MOB4 PPP2R1B â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
EIF4E2 EIF4EBP1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
ATP6V1C2 ATP6V1F â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
ATP6V1B2 ATP6V1H â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
SOS2 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5220477 7629138
PPP2R5C PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 6549523 1328865
PRKAA1 PRKAB1 â—¼   PHOSPHORYLATION ✅ + 0.93 0.93 Signor 17728241
ATP6V1C2 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ATP6V1B2 RRAGA â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
BRAF KRAS â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ATP6V1B1 ATP6V1E2 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
PIK3CB PIK3R3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ATP6V1B1 ATP6V1C2 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
DEPDC5 RRAGC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
ATP6V1C2 ATP6V1E2 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
PPP2R1B PPP2R5E â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
PIK3CB PIK3R2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
PPP2R1B PPP2R5C â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
PPP2CB PPP2R5E â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
ATP6V1B1 ATP6V1G2 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
NPRL3 RRAGA â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
ATP6V1B2 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ATP6V1C2 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ATP6V1C1 ATP6V1D â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1C2 ATP6V1G2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1B1 ATP6V1F â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1A ATP6V1G2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1B2 ATP6V1C1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1B2 ATP6V1G2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PIK3CA PIK3R3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1C1 ATP6V1F â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PPP2R1B PPP2R5D â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
MTOR RRAGA â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PPP2R1A PPP2R2B â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
ATP6V1A ATP6V1C1 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
ATP6V1A ATP6V1F â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
DEPDC5 RRAGA â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
STK11 STRADA â—¼   PHOSPHORYLATION ✅ + 0.94 0.94 Signor 12805220
ATP6V1B1 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
IGF1 INSR â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
MTOR ULK1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
ATP6V1A ATP6V1B1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
BRAF NRAS â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
AKT1 FOXO1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10358075 25241761 10358014 16076959 31844113 18786403
STRADA STK11 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5217549 15733851
DVL1 DVL3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
PPP2R2A PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17245430 5219546
RRAGD RRAGB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18497260 33961781 28716898 11073942 20381137 24337580 22424946
ATP6V1E1 ATP6V1G2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
PFKFB2 PRKCA â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
RHEB RPTOR â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ATP6V1B2 ATP6V1C2 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
MIOS SEH1L â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RRAGB RRAGD â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
PPP2CB PPP2R2D â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
ATP6V1C1 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BRAF MAP2K2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
RRAGC RRAGB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25567906 21981924 33961781 28716898 11073942 20381137 25561175 24337580 22980980 22424946
RRAGC RRAGA â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 25567906 21981924 16713569 31601708 21816923 23184942 33961781 26186194 33157014 11073942 28716898 20381137 25561175 24337580 25936802 22424946
ATP6V1A ATP6V1G1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PPP2CB PPP2R1B â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PPP2R1B PPP2R2A â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAB1 PRKAG2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAA2 PRKAG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
PRKAA1 PRKAG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
MAP2K1 MAPK3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
ATP6V1D ATP6V1G1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5220480 7642581
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
RICTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24036451
MTOR RICTOR â—¼   COLOCALIZATION ✅ 0.97 0.97 mint 21045808 8088164
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
TSC1 TSC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16464865 25263562 11290735 17077083 12511557 11741832 10807585 11175345 20166753 15342917 30514904 11741833 17658474 15963462 16339216 20169078 10585443 14551205 9580671 12167664 10915759 16424383 20412061 12869586 16636147 9809973 14651849 28561026 15851513 17693255 21134130 15340059 12176984 15851026
GRB10 INSR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10871840 9369444 12551896 8621530 7479769 9506989 12493740 19648926 9006901 15664450
ATP6V1B1 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
RHEB TSC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PRKAA1 PRKAG1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
GRB2 SOS2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ATP6V1B1 ATP6V1D â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
INS INSR â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
MTOR RRAGC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ATP6V1A ATP6V1C2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PRKAA1 PRKAB1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
AKT1S1 MTOR â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
AKT1S1 RPTOR â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
ATP6V1E1 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
SLC3A2 SLC7A5 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CAB39 STK11 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ATP6V1A ATP6V1H â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
TELO2 TTI1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
EIF4EBP1 EIF4E â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16504179 5218377
DEPDC5 NPRL3 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
TBC1D7 TSC1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ATP6V1E1 ATP6V1H â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ATP6V1E1 ATP6V1F â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
MAPK1 RPS6KA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
TSC1 TSC2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ATP6V1B2 ATP6V1F â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
EIF4EBP1 MTOR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ATP6V1F ATP6V1H â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MAPKAP1 MLST8 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
ATP6V1D ATP6V1H â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
ATP6V1A ATP6V1B2 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ATP6V1B2 ATP6V1E1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
PIK3CD PIK3R1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ATP6V1B2 ATP6V1D â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ATP6V1D ATP6V1F â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PIK3CA PIK3R2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
SOS2 GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 31980649 32062451 21988832 17474147 14679214 21706016 7629138 33961781 20936779 10940929 19380743 32203420
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
INSR IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11781100 25667086 16582879 17167487 7935368 10455177 11606564 7499194 15629149 8662806 8626379
EEF2 RPS6 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
LAMTOR2 MTOR â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MAPKAP1 MTOR â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PRKAA2 PRKAG1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPARG PPARGC1A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR2 RRAGB â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RRAGB SLC38A9 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MOB4 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MOB4 PPP2R1A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2R1A PPP2R3B â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MOB4 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ATP6V1A ATP6V1E1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR1 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR1 RRAGD â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR4 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PRKAB1 PRKAG1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MTOR RHEB â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
BRAF MAP2K1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
IRS1 PIK3R1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF4EBP1 RPTOR â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MAPKAP1 RICTOR â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SEC13 SEH1L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MLST8 MTOR â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5C â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ATP6V1A ATP6V1D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF4E EIF4EBP1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CB PPP2R5D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1B PPP2R5A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R2D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R5A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R2A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R5E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R5D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ATP6V1D ATP6V1E1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CB PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CA PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CA PPP2R2D â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RRAGB RRAGC â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RRAGA RRAGD â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPTOR RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CB PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGA SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGC SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
STK11 CAB39 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
CAB39 STRADA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
STK11 CAB39 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
CAB39 STRADA â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
PPARG CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23455892 18927468 14764597 15486348 11287611 20651819 15041706 19075513 15193259
TP53 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 24189068 8702807 10669755 22270849 12808109 17942917 19086036 20731879 16061648 20554748 24460719 11798189 10082575 15205322 18769160 19800042
CREB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23447091 16503642 18957421 9990041 12504100 10915780 15116100 22271686 14764597 16522741 18713830 24065533 10201372 22751440 18988190 12391146
GSK3B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 26907733 16944320 27546592 11967263 14663202 8524413 16504004 29969496 19767775 21347341 25142862 11311237 30736789 14597415 25591548 19645770 10385618 20548028 10766840 10929713 23565238 16039586 17570479 18818515 18167338 12615961 12413951 17046823 19071090 18598945 15465828 19374252 26121043 26432751 18319725 12969793 23733133 22922870 24134204 10486203 12459251 15020233 18769147 10910956 11152665 21317297 20537194 22099186 18328826 11124803 17070615 19757160 22470469 23552696 16732330 27695879 29554905 16103118 15075324 14536078 9832503 28090171
CHUK CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 10910956 17666529 9832503 23343194 21285352 18974774 10766840 22761862 22290435 16039586 16103118 19619488 19623618 15212693 17143292
ELAVL1 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12963828 18519672
ELAVL1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18680106 12963828 18519672
ELAVL1 CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12963828 18519672
FOXO1 PPARGC1A â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 10364186 15668399 16122419 19449109 25464856
FOXO1 PPARGC1A â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 10364186 15668399 16122419 19449109 25464856
SKP2 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
AKT1 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 FOXO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19244250 16100571 18202312 23509296 19690465
FOXO1 G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15047713 12130586 22296760 22384829 12373635 16308421 10960473 21081708 16492665 22521266 16804074 23995837 12556524 11467835 12507516 18805788 16037130 20577053
FOXO1 SREBF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24478438 16492665 18202130 20868688 22511764
FOXO1 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22296760 16375695 16492665 22521266 16804074 23995837 11467835
AKT1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 21440011 10358014 11756412 10358076 31308176 20452955 21798082 11410590 20398329 11311120 11544290 28279977 10217147 15132996 23331499 19216069 11237865 20214616 11463845 16076959 11030146 12228231 9829964 18951090 23180781 17570479 10102273 18593906 17646672 16680151 12456685 18423396 18985696 18988627 17962350 30728292 16670091 18786403 14664696 25241761 16341064 11980723 10358075 2984676 13679577 12560069 10377430 11251083 17680028 2987962 17254970 11864996 20041807
AKT2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 19216069 17680028 11756412 17646672 20214616 11463845 20705244 20452955 9829964 20398329 10102273 18593906 16680151 10377430 10217147
SGK1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 23331499 10358014 17640988 11410590 21531565 11980723 19965929 12560069 17684529
SKP2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15340381 17522590 15147722 17646672 12820959 15668399 11516665 15071497 15688063
HNF4A FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12519792 19740748
AKT3 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 19216069 17680028 11756412 17646672 20214616 11463845 20452955 9829964 20398329 10102273 18593906 16680151 10217147
FOXO1 G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16840535 11672436 11467835
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
SGK1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11154281 18570873 18925875 19584721 20338997
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22412893 22848740
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
FOXO3 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16840535 22563476 19608644 12027802
SGK1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 23331499 27187382 18925875 24558442 21963429 20068231 19584721 21531565 18570873 10102273 23161797 18985696 20338997 29017179 20738430 11154281
IKBKB FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 25241761 20300203 20625400 25849741 23691078 23262029 19701188 21911455 22649777 21443462 15084260 22531926 16806782 30142927 19188143
MAPK1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18204439 29445193 22128155 10102273
PRKAA1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17900900 17711846 22848740 29445193
CHUK FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15084260 23691078 20300203
AKT2 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19951971 19216069 17680028 11756412 17646672 20214616 11463845 20452955 9829964 20398329 10102273 18593906 16680151 10217147 19188143
AKT3 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15023346 19951971 19216069 17680028 11756412 17646672 20214616 11463845 23109003 20452955 9829964 20398329 10102273 18593906 16680151 10217147 19188143
PPP2CA FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19029949 15207915 20110348 17322870
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
FOXO3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18644865 10783894 16288288 20673124 11094066 17646672 15509806 11994454 11154281
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 LAMTOR2 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
SOS1 GRB2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 16520382 31980649 32062451 8493579 21988832 14679214 7510700 7514169 21706016 10319320 32203420 9872323 9797459 34407391 16906159 10716926 12577067 8810325 7629168 11960376 7664271 8626525 15192046 7629138 11997436 8943292 10207103 8695800 10570290 10025673 8112292 11726515 8816480 20473329 7559490 7773779 9447984 19380743 7642581 7527391 9716598 9344843 10477741 16713569 19323566 7516467 17474147 9569023 8188688 16893902 11964172 9478994 33961781 8479541 28166272 9009162
GRB2 LAMTOR2 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
PTEN GRB2 â—¼   REGULATES ✅ 15.0 1.0 ACSN 10648629 10753747 11747822 12040186 15584861 15721744 16288286 16982858 17218262 19847259 22179046 22465479 23732914 24254977 25364523
PTEN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
GRB2 SOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 21988832 20936779 19531499 14764585 10940929 19380743 21706016 10359574 14679214 17474147 21779497 9199344 7629138
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
PRKCA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11704645 12598525 19074803 8903320 9160888
PPP2CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 10592173 7780739 18588945 2154696 20626350
PPP2CB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 16680151 16456541 10995457 18042541 7780739 18588945 2154696
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8939914 12832467 9915826 17906627 32296183 19282669
MAPK1 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21988832 18156174 12016217 25241761 12832467 23602568 8939914 10480933 9915826 17906627 10980595 10856237 19282669
MAPK1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25409419 11733495 16574647 9099735 9030579 15507114 26670611 17570479 17998334 18596912
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17081983 32814053 20385094 11532940 7601337 23331499 15342917 8939914 21071413 23047924 20068231 11335727 9687510 12618428 18988627 18669648 23519423 23109003 18691976 12594221 9915826 17906627 8202512 9430688 19651622 12832467 11500364 14966081 29997244 25730857 8387505 10411321 18212344
MAPK1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11581251
MAPK1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21071439 19339977 19864431 21325048 22493283
MAPK1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 11691836 18767875 11553333 12665511 25702871 19413330 10405182 18187866 19664995 12747827 10942774 9092573 15051500 20068231 9465032 27387559 11410517 11777913 18669648 8083223 12105188 17386266 25762619 17287340 9405468 12588975 12370290 19651622 10779345 27402756 10364159 11799119 26170285 12912989 33658337 16339216 12759354
MAPK1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10197981 8816480 9922370 8626428
MAPK1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15342917 15851026 18794886
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 15001544 17081983 18949383 16123357 27014871 16914728 17360977 16099428 30401435 16131083 17640984 12510059 15613682 21850561 14579029 20594869 8626671 9395471 19651622 15576463 22289259 14769130 16020478 17242212
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10702263 11606045
MAPK1 STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25679014 25846811
MAPK1 GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15952796 18220336 18669648 20068231
MAPK1 PPP2R5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16456541
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
PRKCA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11704645 12598525 19074803 8903320 9160888
MAP2K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 9694850 17081983 11319218 18799465 17389395 9447970 15342917 8226933 15851026 12270934 12644307 11242034 1381507 17906627 9677429 11986622 8376945 7992057 11948414 7687743 9731057 19197339 11704645 7565670 12750173 12932319 8626767 23331499 12048245 7559390 17272394 15811950 26987942 19494114 18669648 18691976 17192257 8388392 7898932 16464493 19369195 12920017 15466214 19690332 11134045 19534553 10995751 7867743 8223433 8248196 10567369 19933846 17563371 1518847 11730323 18983981 16186792 16135787 15951569 19058874 15212693 10748187 9560161 9925641 9733512 18083107 11104681 9006895 17569879 21071413 7731720 1330321 93330262 19541618 15466476 12925710 11971971 11136732 11118451 10746662
PPP2CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 18588945
MAPK3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21757713 21071439 19339977 19864431
MAPK3 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10627507 10915800 18669648
MAPK3 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 23602568 8939914 12832467 17906627
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23331499 15342917 18039929 12832467 23109003 8387505 14966081 9915826 21071413 17906627 9430688 11335727 18988627 11532940 10411321
MAPK3 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18156174 25241761 12832467 8939914 9915826 17906627 10980595 10856237 19282669
MAPK3 GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15952796 18669648 18220336
MAPK3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 14654779 21478863 19541618 21135229 16508002 19933846 15664191 8621729
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
MAPK3 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11581251
MAPK3 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 29145629 7478566 23331499 8816480 7739560 17570479 9922370
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
MAPK3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15342917 16244323 15851026 18794886 19188143
MTOR MLST8 â—¼   PHYSICAL_INTERACTION 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 MAPKAP1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 DEPTOR â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 RPS6 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR MLST8 â—¼   SHARES_COMPLEX 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 DEPTOR â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 RPS6 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 MAPKAP1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR MLST8 â—¼   ENZYMATIC_REACTION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
AKT1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
PRKCA MLST8 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10679481 10871288 16492141 18851840 20027184 21474067
MLST8 RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MLST8 SGK1 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 18570873 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20338997 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 DEPTOR â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 DEPTOR â—¼   DOWN_REGULATES ✅ - 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR MLST8 â—¼   LOCALISATION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MLST8 â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RHEB MLST8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17604271 15854902 19299511 16636147 12718876 15878852 17470430 19143635 12906785 18466115
MLST8 SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18000759 20027184 17680028 19151919 19720745 21157483 18925875 10722653 18570873 17461779 21474067 19143635 20338997 12408816 11274345 19568798
MLST8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19203586 15718470 19568798 15169778 19720745 17517883 18925875 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
MTOR DEPTOR â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RPS6 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR MAPKAP1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR DEPTOR â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RPS6 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PRKCA MTOR â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10679481 10871288 16492141 18851840 20027184 21474067
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR SGK1 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 18570873 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20338997 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR DEPTOR â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MTOR DEPTOR â—¼   DOWN_REGULATES ✅ - 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
TELO2 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20427287 18160036
CHUK MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18519641 24990947 18490760 27027448
RHEB MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18670866 18075516 18550814 16631613 18466115 16915281 23331499 15772076 16098514 20006481 15878852 21071413 23272152 19299511 15854902 19487463 20226003 19143635 17604271 16636147 17470430 12906785
TTI1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20427287 20810650
MTOR GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15952796 21659605 21659604
MTOR AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 17517883 18372248 19203586 27418134 17277771 15718470 26491696
MTOR SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 18000759 20027184 21157483 17461779 11832334 20338997 21474067 19568798 10191262 19720745 18925875 21981278 21963429 30837283 19143635 9764820 28106162 17680028 19151919 10722653 18570873 12408816 11274345
MTOR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 22570710 15952059 19561084 21282364 25973388 14769130 11287630 9335553 17698034 20863384
MTOR DEPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22017877 22017876 22017875 19446321 28086984
MTOR RPS6KB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12150925 11914378 17510057 21157483 17680028 19864431 12087098 15755954 16286006 9465032 15060135 11733037 14560963 12408816 20932932 23486913 19568798
MTOR AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17517883 18372248 19203586 17277771 15718470
MTOR ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 18000759 19225151 21157483 25759175 15755954 28464882 19446321 27681874 26417067 28518135 19706736 24119841 27325266 26906453 27731364 29686608 25026281 27935582 28366635 28674405 27617292 26869683 29507183 25679763 28389629 25686248 19568798 27387347 21383122 26118643 32134989 26887051 12150925 29540819 29849901 10995454 23136410 30093610 19864431 24358342 26844203 29787772 30127742 19690328 21460634 26447757 26589724 21258367 22770472 29057166 29752434 29066806 17680028 19151919 24998849 30174616 26734992 17595159 12408816 11274345
MTOR ULK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12150925 19211836 18000759 19225151 21157483 17680028 19151919 19864431 15755954 19446321 19706736 12408816 11274345 19568798
MTOR AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 17604271 17386266 18030348 28978182 19114562 17517883 26876939 18570873 18372248 17277771
MTOR EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 132.0 1.0 Omnipath 17510057 17081983 11691836 22873724 18767875 16824195 19147279 23077579 24303063 28272965 19690332 11438723 12665511 17043358 19413330 10405182 20670887 19209957 19664995 15070431 9826548 12747827 10942774 16242075 9092573 12604610 20068231 9465032 21190521 23360111 17991864 25686248 9204908 11777913 18669648 12150926 8083223 20537536 12105188 17386266 24205284 17517883 26985829 19291795 23972597 16288292 17487921 8895571 17287340 9405468 20227039 12588975 12370290 17717968 23486913 19651622 10779345 26255626 18220336 16404421 18283322 10364159 15066126 12912989 17693255 15767663
MTOR AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 24670654 16697215 11438723 21592956 20398329 17461779 18372248 21177249 21045808 20338997 15808505 16221682 20138985 20489726 15899889 20214616 8978681 21474067 14970221 19203586 17660512 15718470 19568798 20333297 23006971 15169778 25241761 18566586 19720745 17517883 18925875 22084251 10949026 14761976 11715018 19143635 17277771 18636226 10910062 15047712 9812896 18505677 21343617 19844585 17680028 19151919 18566587 9736715 23872070 10722653 20832730 18570873 17013611 17052453 12408816 15364915 11274345
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
KRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
TP53 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10321740 19763735 21057544 18661553
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
IRS2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21241768 23439647 11024460 19561084 12107746 9334184 15715521 11438664 15514089 26496610 9233603 23617393 8910607 9852124 19109239
INSR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 15629149 17389395 8276809 18083107 11796522 8385099 20068231 8567177 16497976 15592455 17570479 9593725 7589433 14729945 17016520 10500481
PTEN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
IRS1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 12444011 11788580 14632132 14511371 19030972 16931767 7486683 21798082 11403293 12173038 8382612 12220227 12767520 10826997 16230374 7680095 23439647 19561084 16150444 12107746 10358772 11748924 12175651 7499365 7935461 15316008 9564850 16354680 16043515 12730242 11416002 7680644 23643389 21540285 8628286 15514089 11438664 8175658 9233603 1381348 25814554
PIK3R1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10527852 16799564 19442713
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3R1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9113989 8596638 21827948 12147247 11733063 22020336 24165795 31031754 14665640
PIK3R1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 19531499 25241761
PPP2CA PPP2R5C â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PPP2R5C AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18039929 19216069 11897496 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
PPP2R5C TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17245430 25241761
PPP2R5C PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18782753 15380617 1328865 28330616 16456541 11929880 10675325 19156129 8703017 7592815
PTEN RAD51 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218252 17218262 18716620 19847259 22179046 22465479 23732914 24254977 25364523
TP53 RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17513613 16322760 20802511 16398215 18769160
TP53 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 8617246 11002423 16713569 16322760 16983346 9380510
RPTOR RRAGA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RPTOR RPS6 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR DEPTOR â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR DEPTOR â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR RPS6 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
AKT1 RPTOR â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
RPTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR DEPTOR â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR DEPTOR â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RHEB RPTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RPS6KA1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18220336 19369195 21325048 18722121 18439900 19413330 18669648 25361081
RRAGC RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21816923 25561175 20006481 18497260 24337580 25446900 21981924
PRKAA1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21460634 18439900
RHEB RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17604271 15854902 19299511 16636147 24337580 15878852 17470430 19143635 16631613 12906785 18466115 25446900
AKT1S1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17604271 17510057 18030348 17386266 18215133 17517883 33230243
PRKAA2 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18220336 19369195 18722121 18439900 20083114 19413330 18669648
PRKAB1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18220336 19369195 21460634 18722121 18439900 19413330 18669648
EIF4EBP1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 18337751 24403073 16824195 12665511 12747827 12604610 18606717 19272448 16837165 12150926 18955708 21071439 16798736 22493283 17502379 15066126 18722121 12912989 15767663
AKT1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 18000759 21157483 11756412 11923280 16697215 20398329 17461779 18372248 15808505 20138985 20214616 19568798 15169778 19720745 17517883 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
RICTOR SGK1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 11154281 11500365 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16469695 16697054 17884153 18570873 18636226 18925875 18931676 19143635 19584721 19622404 19686080 19809470 19847258 20338997 20832730 26159692
MAPKAP1 SGK1 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 18570873 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20338997 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
SGK1 CREB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 15733869 2052361 18088355 10826704 7608156
TP53 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9058378 18430410 19756449 8647846
PRR5 SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18000759 20027184 17680028 19151919 19720745 21157483 18925875 10722653 18570873 17461779 21474067 19143635 20338997 12408816 11274345 19568798
RICTOR SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21204013 15340381 12820959 18925875 19584721 18636226 20832730 18570873 19143635 11500365 20338997 15071497 15688063 11154281
MAPKAP1 SGK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18000759 20027184 17680028 19151919 19720745 21157483 18925875 10722653 18570873 17461779 21474067 19143635 20338997 12408816 11274345 19568798
SGK1 SLC2A4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17382906
SGK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 18088355 11909979 8688081
STK11 STRADA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
STK11 STRADA â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15509864 18687677 19197243 19942859 20160076 20484410 23030059 8910387
PRKAA1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
PRKAG1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
PRKAA2 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
RPS6KA1 STK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 28522753 11853558 25846811 11297520
STK11 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10642499 14976552 8910387 18693249 12764152 26489410 15509864 14614828 12413941 20160076 19197243 15980064
STK11 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12973359 25069613 20592207
STK11 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 25763354 17875968 15987703 16107342 11035045 12077256 18321849 23379765 21779440 12297295 25336918
STK11 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8910387 15509864 15661536 20160076 19197243
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
STK11 PRKAG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
STK11 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 16434556 25792737 14985505 14976552 20489196 21062936 20656472 20616029 17255104 16041368 25696921 21399626 12391032 20160076 17244528 15980064 17054914 22517326 14532170 21918180 28694351 18693249 26771234 20801214 16600998 18195011 28723898 16912160 22039048 26068970 14614828 19884317 25679763 22575644 19197243 27864418 30022161 25683918 18303014 17287464 15327994 12764152 16054095 15509864 26506235 14511394 27181208 28625738 25874865 8910387 17276402 26247630 21680840 19414597 23418352 24289924 15383373
STK11 STRADA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 20562859 25241761 12805220 14676191 21860411 19513107 15561763 25852190 15733851
STK11 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19197243 15509864 8910387 20160076
TNF TNFRSF1A â—¼   PHYSICAL_INTERACTION 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
TNF TNFRSF1A â—¼   PROTEIN_INTERACTION 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
TNF MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
PPARG TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20376096 11009565 14646597 20473515 11124825 17532302 17464333 19031802 14656714
TNF TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 98.0 1.0 Omnipath 17145710 19084540 8288897 11448951 23746843 22801493 14732063 2848815 9568681 2158863 8182064 9488135 23070005 20080539 11239407 26670046 14743216 21724995 21133840 24070898 25911380 7852363 2170974 17151142 26186194 27560715 25241761 23032187 24726327 20103630 8805640 11502070 19442713 3034874 23955153 18067990 22099304 15485837 22675546 12753742 1310388 12887920 19287455 10634209 2170559 1331108 24980434 22028622
TNF IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22328823 22869320 19808894 12110133 11160134 12409308 22266116 21478880 11684411 25352752 24966659 29425748 16754954 25355439 22823902 18443205 24648009 26976796 25645159 23592917
TNFRSF1A CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23815148 21724995 10795740 24323043 10755617
TP53 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12734185 19861536
TP53 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11818510 16895524
TP53 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15469934 11557753 17434128
TP53 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11514734 18555006 10953306 14741382 19107228 20124454 8274455 16061648 10448271
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
TP53 IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12631625 18281476 18174288 21460853
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22957312 15843377 12917634 21637289 17344317 12839924 11545734 18172008 19173293 20554748 19079342 14984207
PPP2CB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 1848668 17245430 14712210
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
PPP2CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17245430 14712210 1848668 16713569 12556559
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
PRKAA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28797070 15866171
PRKCA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18812399 9935181 15659650 9315650 19933256 16713569 9571186 1454855
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
TP53 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21336307 18431400 18339852 12620407 17409411 18172008 17823410 16713569 21518799 21483453
FZD7 WNT1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
DVL2 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT1 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
WNT1 FZD2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT1 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14642436 15578921
WNT1 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15454084 1545408415454080 11448771
WNT1 FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 91476519147651 9147651
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
DVL2 FZD7 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
FZD7 WNT11 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
WNT2 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23815780
WNT11 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10862746
WNT3A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18215320
WNT3 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25892522 18313787 24032637
WNT5A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10990458
PRKAA2 TBC1D1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17995453 20701589 21454505 20837646
PRKAG1 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20562859 10698692 26186194 9224708 17012231 16054041 25416956 31515488 32296183
CAMKK2 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16051629 22561688 21228273 34044797 24959379 17244528 15980064 23716691 25065674 15465812 34421352 12413941 19197243 18692468 33502468 34216621 23863464 34064003 16054096 16054095 15509864 33675805 20538596 19958286 25937278 34290400 34253170 23612973 22304913
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
PRKAA2 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 19651622 11052978 20166139 9029219 18669648 18767875 2900138 12015362 20068231 18707149 19061860 17519230 7907095 7915280 29899443 16326698 18212344
PRKAA2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18692468 16959574 19339977 14651849
PRKAA2 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16308421 16148943 15454081 18626018 20577053 16817901
PRKAA2 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 11500364 11171059 14709557 15024086
PRKAA2 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21205641 19584320
PRKAA2 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12740371
PRKAA2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18692468 19339977 14651849
PRKAA2 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 11069105 19651622 17924679 18767875 20068231 1322130 19690332 12853467 19413330 18669648
PRKAA2 ACACB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 14532170 12488245 9148944 20166139 12413941 14613924
PPARG ADIPOQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 19843873 20668453 19324019 19833717 20473515 12829629 15764598 18804108 19954946 11533050 16803864 20622112 18296319 18373719 12927809 20484463 23381555
PPARG ADIPOQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12829629 20592862
ADIPOQ ADIPOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21284979 12802337 16622416
ADIPOQ ADIPOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12802330 21284979 12802337 16622416
WNT7A FZD10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12857724 18567805
WNT7B FZD10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15923619
SREBF1 SCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11414710 16943421 22279139 23221600 18481202 16368743 10400691 23019225
TSC2 TBC1D7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17658474 22795129 18466115 20095038
TSC2 TSC1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
TSC2 TSC1 â—¼   PROTEIN_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
AKT1 TSC2 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
TSC2 RHEB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12906785 16636147 17680028 19022819 20146692
TSC2 TSC1 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
PRKAB1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18692468 19339977 14651849
GSK3B TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24795562 12511557 23265840 15972957 16959574 22980037 22732551
RPS6KA3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17570479 15342917 16244323
PRKAA1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19339977 33271062 14651849 16959574 15261145 28591720 18692468 20363874
AKT1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 75.0 1.0 Omnipath 16873412 12820960 17018601 11756412 32308763 11923280 16697215 19690332 21893193 20398329 18372248 21177249 12438239 18466115 15808505 29042482 20138985 15342917 17597835 20214616 12271141 16702951 20837138 17570479 26844273 15169778 17386266 10949026 16288292 24590173 11715018 15661536 18636226 18411301 20028854 9812896 16636147 20169078 17680028 12172553 19664994 18707149 10722653 12150915 18570873 20832730 12364343 17052453 18283331 21666717 27451907
RPS6KA1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 15342917 17081983 16244323 15963462 29351204 20068231 19690332 15757502 15851026 20045011 22980037 28289099
AKT2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12150915 12167664 12172553 19188143
TSC2 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 15340059 15854902 23331499 16636147 12869586 17680028 21071413 20146692 12771962 20226003 12906785 12842888
TSC2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 84.0 1.0 Omnipath 12167664 16424383 12511557 21134130 14551205 10915759 11741832 15340059 20166753 23331499 15342917 9580671 21071413 16464865 15851026 11290735 9809973 15851513 12869586 10807585 15963462 10585443 11741833 20412061 20226003 11175345 25263562 16339216 18411301 16636147 14651849 17658474 17693255 12176984 17077083
RICTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 15718470 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19203586 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 22475393 22924465 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
DEPTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MAPKAP1 PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
DEPTOR MAPKAP1 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR MAPKAP1 â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 15718470 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19203586 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 22475393 22924465 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MAPKAP1 PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PRKCA MAPKAP1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10679481 10871288 16492141 18851840 20027184 21474067
MAPKAP1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MAPKAP1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19203586 15718470 19568798 15169778 19720745 17517883 18925875 10949026 11715018 19143635 17277771 18636226 16962653 9812896 19844585 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
RICTOR PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RICTOR DEPTOR â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR DEPTOR â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
PRKCA RICTOR â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10679481 10871288 16492141 18851840 20027184 21474067
AKT1 RICTOR â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 RICTOR â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 RICTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 21177249 20338997 19402821 15808505 20138985 21339740 16603397 20214616 21474067 16919458 15718470 19568798 17545609 15169778 18566586 25241761 19720745 18925875 22990118 10949026 11715018 19143635 18636226 18411301 9812896 21343617 17680028 19151919 18566587 10722653 20832730 18570873 17052453 12408816 11274345
CHUK MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
IKBKB MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
PPP2CA MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18299321 17079228
MAP3K7 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 14960582 16893890 15836773 33895773 12547194 25241761 24911653 2547194 9742107 18949366 11274345 20200282 20194509 10094049 18855897 10187861
MAP3K7 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
MAP3K7 RAB8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 34088839 32227113 32017888 31292254 32601174 33887226 30709905
MAP3K7 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 20615388 18692468 15980064
MAP3K7 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 24911653 11129660 25195736 16006187 16260493 15502405 14530355 10779355 28159912 10094049 10837071 15836773 25659581 10195894 9689078 17363973 10807933 15214841 16186825 16493424 10022904 18316610 10187861 12547194 33895773 28475177 16301747 15691841 15620648 15327770 29748387 19632174 11460167 17965022
MAP3K7 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
EIF4EBP1 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 111.0 1.0 Omnipath 24211447 24722188 35044719 16824195 18957614 8521827 25416956 11553333 10405182 22509910 11605658 17254965 16271312 17689282 22586265 16648488 16467844 12747827 16242075 10772338 12604610 12867426 12747804 10330171 21798997 12482586 16189514 15550948 21191102 12071973 10406811 18955708 12105188 20224576 17353931 26186194 8816458 17316564 15094042 10753870 16798736 10022874 32296183 19834456 10698949 15153109 15661536 11146653 12588975 16504179 10394359 7935836 7651417 22678294 20880835 10364159 23584478 15767663
PRKCB EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8662663 12897141 9155017 11723111 95301551 11463832 9878069
PRKCA EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1911648 8662663 2355012 12897141 9155017 17570479 11723111 95301551 11463832 9878069
RHOA PTEN â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10953004 11698448 11729192 11739775 11992112 12194823 12361600 12740575 12778124 14657501 14744429 15761148 15793569 17517963 18037882 18423981 20008297 20351293 20535745 21178402 21642958 21840487 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
PTEN AKT1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218262 17409395 19440036 19847259 19945467 20609352 21084277 22179046 22465479 23732914 24030100 24254977 25364523 26597054 27328425 27572739
PPARG PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18065496 16775433 16425225 23867870 20198337 11378386
GSK3B PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 20080742 19797085 16107342 12040186 23379765 16611981 10671551 16039586 17570479 12615961 25763354 19575820 17444818 20537194 26339505 23210979 17052453 18455992 16371461 11274345 12297295
AKT1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19903340 15987703 10790335 20596030 10592173 20605778 10866658 12077256 11035045 16107342 12297295
PTEN SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
PTEN PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 12628188 17673906 21779497
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
HRAS PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9069260 9113989 9235916 21779497 11739523 10545207
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
DVL1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
CREB1 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20359506 17451429 17018277 21156859 11557984 22980225 15653680 19583954
PPARG PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16513826 32991581 29182484
PRKAA1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20640476 17609368
AKT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17554339
AKT2 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21297943 17554339
RHEB DEPTOR â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
RHEB DEPTOR â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
TSC1 RHEB â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12906785 14551205 16636147 17604271 17680028 17693255 19022819 20146692
AKT1 RHEB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
RHEB DEPTOR â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
TSC1 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17604271 16636147 20006481 17680028 20146692 14551205 17693255
RHEB AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17604271 17510057 16636147 12820960 12869586 17386266 19446321 19143635 17277771 18466115
RHEB BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19651622 20166139 16803888 18691976 20068231 18452278 12214276 15150271 18669648
AKT2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19609947 12048203 10485710
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
CHUK IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 16510874 23343194 21285352 22020335 23296977 11274345 16039586 17439715 20920541 20530697 15337521 8545107 19619488 19623618 17565603 17143292 20006983
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
PPARG CD36 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10432118 10485906 12223527 12244147 14610620 15634881 17681149 23124025 24204259
PPARG PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21406501 20124556 11399762 21450790 7799943 11728630 12560325 9518257
PPARG SLC2A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16670091 12777391 20406953 12777397 16096283
PPARG CD36 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17322100 18072748 16959872 18948972 20950277 18242221 11795270 10432118 14752028 15104237 25721714 11867619 16556603 11595817 16407258
PPARG LEP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9030601 20473515 15764598 19954946 23254958 19689798
PPARG SLC2A4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18391971 17317207
RPS6KA1 DEPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22017877 22017876
EIF4B RPS6 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
EIF4B RPS6 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
AKT1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18836482 17570479 25749412
RPS6KA1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15187187 21233202 17924679 16286006 16083285 15071500 17664694 16763566 19114553 19413330 15239952
AKT1 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23807222 28446188 22733130 19270695 20160512 19549334 21963805
DVL2 WNT11 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
DVL2 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
PRKCG DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12958364 11940581 21386996 11313945 15567848
PRKCA DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12958364 11940581 21386996 11313945 15567848
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
PRKCB DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12958364 11940581 21386996 11313945 15567848
WNT7B FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15923619 24032637
WNT5A FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10990458 16602827
TSC1 TBC1D7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17658474 22795129 18466115 20095038
AKT1 TSC1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
AKT1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12167664 11756412 11923280 16697215 20398329 18372248 15808505 20138985 20214616 15169778 10949026 16288292 11715018 18636226 9812896 17680028 12172553 10722653 12150915 18570873 20832730 17052453
IKBKB TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 23144589 22408430 20300203 22264792 21559457 22435559 18075516 20146692 22003905 22017429 17693255 22980037 18716620 19188143
IRS1 SOS1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
PRKCA IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869320 15364919 16574739 17570479 15516986 15069075
INSR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 10655627 7651388 25472611 1385403 18083107 12220227 23331499 28328746 7504175 19534553 7499194 7537849 7935368 11572799 11781100 10592173 17570479 17575262 18988627 12446583 15629149 10455177 15870194 11416002 12101187 17167487 8530377 8626379 8662806 11606564 2159922 8626723 16020478 16582879
IKBKB IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 10722755 19651622 24337154 18443205 23050932 15199052 20953398 25381390 16129690 29767231 11606564 18077418 14583092 15613682 16099428 12351658
RPS6KA1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17709744 15364919 17081983 21798082
IGF1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 26474286 28545881 26956053 25886138 15952059 18762365 22362362 19762915 11160134 22941977
INS IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25309812 25472611 23891856 20150288 29069585 24036112 21518983 11160134 19357636 22198320 17579213 21677282 11684411 23983791 28955049 25760026 21850561 22832498 19808019 22698915 23815272 18443205 20601126 16150913 25383313 27695421 23115649 22728334 19752148 19171749 27819676 16516141 22418434 19542202 25381390 22516431 24763529 26866272 23695665 23431498
IRS1 PIK3CD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16931767 12175651
IRS1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 11120660 7559478 10358772 16931767 12730242 12175651 7499365 15316008
IRS1 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 9415396 16931767 12175651 10417350 7542745 25814554
IRS1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16354680 16150444 16931767 10592173 12175651 1380456 23643389 1381348 11313948 9374521 20966354 9624169
IRS1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16931767 14623899 11416002 12175651
AKT1 SLC38A9 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGC â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
AKT1 RRAGD â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
GRB10 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11809791 15722337
PPP2R5D AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
INS AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 29432553 23912456 11679435 23866690 17335965 24646332 23798298
PIK3CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25793261 19117013 21041639 24950409 21816939
PPP2CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 21159657 26256536 15743829 10026142 20452955 11438723 18559511 11839802 19996169 19216069 16406523 10995457 18042541 19556239 18588945 16680151 11087733 18160256 15367694 18039929 18077353 11812651 16044149 20360384 12637511
PPP2R2A AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 18588945 16680151 20360384 16406523
PPP2CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15367694 11087733 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 8650155 18588945 16680151 11812651 20360384 16406523
PRR5 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 24670654 16697215 21592956 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 15718470 19568798 15169778 18566586 19720745 18925875 10949026 11715018 19143635 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
AKT1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 20058876 14688280 11510412 25241761 20230923 20068231 18452278 11410590 17570479 10869359 18669648
AKT1 PFKFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28235572 15896703
AKT1 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19376078 16340011 16083285 26506913 27784766 24467442
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 11691836 18767875 12665511 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
AKT1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11175347 11756412 12356771 15733869 20452955 20398329 11160957 10217147 19216069 20214616 11463845 9829964 7958915 12235136 16680151 17646672 9687510 8887554 11698596 8688081 17680028 9528766 11018520 11969286 12519783 11909979 15725726
AKT1 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19651622 17924679 18767875 23457334 10521487 20068231 1322130 12853467 17570479 19413330 18669648
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 63.0 1.0 Omnipath 18000759 17081983 17510057 12820960 21157483 11756412 11923280 16697215 19690332 19446321 20398329 17461779 18372248 19413330 15808505 20138985 23415227 20214616 12524439 20068231 14973226 19568798 18669648 17329361 15169778 12869586 17386266 19720745 17517883 11352916 10949026 11715018 19143635 17277771 18636226 19651622 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
PRKCA INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15212693 2110001 12472845 17570479 8454604 1956339 10819237 7926007 92065884 8463287
PRKCA CLIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20519438 17570479
PRKCA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 92316961 15212693 26888287 1377674
PRKCA KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20802526 34333552 23331499 25713064 27791178 18458061 9922370 18182391 16483930
PRKCA PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18669648 1322130
PPP2CB IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19607706 17188031
CREB1 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 11160957 11698596 12842905 9770464
CREB1 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 11160957 11698596 12842905 9770464
CREB1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 11160957 11698596 12842905 9770464
CREB1 PPP2CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17526027 19155497 19750005
CREB1 G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20022930 12760745 17635106 15388792 11544200 26652733 19583954
CREB1 PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21406501 20688914 10854692 20022930 1655770 16803882 8093246 20797423 20137375 24046422 10085123 23058912 9593667 8386317 11092886 19583954
CREB1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11160720 20857405 8641461 17325033 12869629 19343785
AKT2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
AKT3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
GSK3B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16568235 12162494
RPS6KA1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 11175347 12356771 15733869 11160957 11544482 15138267 11532940 9829964 7958915 10558990 12235136 11335727 9687510 8887554 11698596 8688081 9528766 11018520 11969286 11909979
RPS6KA2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 9829964 11698596 11018520 11160957 11969286 12235136 7958915 9687510 11909979 8688081
RPS6KA3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 9770464 9829964 11018520 11160957 11698596 11969286 12235136 17570479 7958915 9687510 1545823 11909979 8688081
INSR IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 19901323 7629118 9195949 18083107 23331499 19534553 7537849 17570479 18988627 7675087 11584304 7526222 12101187 8626379 8662806 8626723
IRS2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10594015 19109239 9651378 15715521
IRS2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9113989 22810696 9374521
SEC13 GOLGA2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10903204 11306556 23378591 9150144 10679020 11285137 23698585 11927603 16624868
PRKAA1 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19419994 20861072 20952391 24727471 26079370 19095655 10862786
INS INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8393875 21743783 21317886 24296476 26374090 29069585 26245346 16956584 19902173 20332342 23363978 23331499 18988627 23302862 22832498 2550426 15870194 11278498 19752148 29512653 23304064 24633815 17227660 22521887 23223021 30197476
INSR GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9506989 15664450 10871840 8621530 9006901 19648926 7479769 12783867 12493740
HNF4A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18555664 10491332 10720084 11994285 14612449 19252740
INS AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 25304263 30179516 23832510 23801578 22307032 20041157 24725432
EEF2K EEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 65.0 1.0 Omnipath 22669845 17081983 18614030 20166139 18767875 21307130 23184662 91085562 21112387 28060762 12194824 19413330 24958351 16858730 3906654 25686034 18188169 16083285 24574971 20068231 30214154 24955726 2261989 11500363 25623400 18669648 8386634 2704236 22352903 20837011 9133370 17287340 2458772 29610153 21203441 19651622 11500364 30218597 12171600 15024086 3693353 18212344 19152646
PPP2CA EEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8386634 2555220 2176079
AKT3 CREB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
PPP2CB AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 8650155 18588945 16680151 16406523
PPP2CB PRKCB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15880462 8749392
PPP2CB AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523 18160256
PPP2R1B PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18715871 17540176 19114990
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA PPP2R5A â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PPP2CA AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15367694 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523 18160256
PPP2CA MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18039929 16680151 1716348 10995457 18042541 18588945 20626350
PPP2CA PRKCB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15880462 8749392
PPP2CA MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945 20626350
PPP2CA AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 15367694 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523 18160256
PRKAA1 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11069105 19651622 20640476 17924679 18767875 20068231 1322130 12853467 19413330 18669648
RPS6KA3 PFKFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17570479 2846551 9211863
RPS6KB2 RPS6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21233202 17081983 92042229 16083285 20146692 12713446 15471950 20647036 20832730 16810323 86287375 20932932 1985906 15358595
RPS6KA1 RPS6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 21233202 29892299 17081983 19369195 16083285 21418524 17360704 17664694 17287340 18187866 18669648 18974095
PIK3R3 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8596638 22402981 9415396 11733063 26496610 25814554
NRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8052307 7820549 9150145 8665852 21779497
KRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAP2K1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
BRAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 20212043 7706312 25437913 9560161 7936666 14970219 18567582 18332145 8413257 23331499 15342917 21071413 7731720 7873542 26496610 10976102 18988627 17667937 16255777 8131746 16888650 15485920 8394352 15175348 15466476 19541618 25600339 25155755 17563371 16810323 8157000 17979178 18039929 94178255 23934108 7835430 7624324 24746704 16135787 7935374 8039496 8621729
MAP2K1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17081983 21105670 16964243 14617795 30711629 18547980 8382613 17188038 17192257 15020233
KRAS BRAF â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 24937142 16294014 12932339 7744815 9020159 15035987 16364920 11325826 16041367 24347342 12932319 10205168 21441910 23993095
BRAF LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
KRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 1386920 23331499 19541618 8601312 14970219 18567582 16135787 12932319 17563371 12917261 19933846 21779497 17635919 19223544 15710605 8073291
NRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 1386920 21478863 9368069 19541618 8601312 14970219 18567582 16135787 7935411 12932319 12917261 17563371 19933846 21779497 8073291 15710605
AKT3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10869359 18451171 11293329 19493313
BRAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 15342917 18039929 19541618 7706312 15466476 25600339 7731720 16135787 17563371 33226073 8668348 17667937 16255777
MAP2K2 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
RRAGA RRAGC â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
RPS6KA1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11584304 11583116 23331499 8250835 7980435 8524413 24931005 19346560 12054501 16039586 12147701 11035810 22615844 16543730
PPP2R5D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
AKT3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 12851486 15023346 21303971 11882383 17680028 9065430 23109003 20214616 22094462 23552696 20398329 21506126 20028971 12040186 18218901
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
PPP2R5A GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
GSK3B SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16054087 16825193 19126544 26589965 26759235
GSK3B EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23584478 17570479 27387559 18701453
KRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
EIF4EBP1 EIF4E2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 28698298 17145710 17368478 15094042
AKT2 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17329361 19651622 17081983 17386266 17517883 12524439 11352916 20068231 18372248 19413330 17277771 14973226 18669648 23682635
AKT3 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17440074 17517883 18372248 17277771
PRKAA1 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20562859 17145710 18480843 8626596 17728241 21232561 16306228 8663446 25852190 8621713 23455922
CAMKK2 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 14985505 21918180 8910387 16054096 16054095 15509864 19197243 14614828 23625915 17244528 18692468 15980064 14511394 23583109
PRKAA1 TBC1D1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17995453 20837646
PRKAA1 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21892142 20577053
PRKAA1 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 11171059 22669845 11500364 14709557 15024086
PRKAA1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24820971 23372762 28295473 21460634 19584320 21205641 21258367 28389629 34421918 34224814 25980607 32978258
PRKAA1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21338323 2165906 16188906 15033481 9636039 18398140
PRKAA1 PFKFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17712357 9836440 12065600 16115917
PRKAA1 SREBF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21459323 21892142 23825667
PRKAA1 ACACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19651622 11052978 20166139 9029219 18669648 18767875 2900138 12015362 20068231 18707149 7907095 7915280 16326698 18212344
PRKAA1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12740371
NRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3CB â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
PIK3R3 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8596638 22402981 11733063 25814554
NRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7923364 11560935 9690470 21779497 8493579
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HNF4A PCK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11557972 7831301 16308421 12840167 7935427 14722127 7819133 19720831 20577053 19651778
HNF4A G6PC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15591035 11864989 22384829 16308421 12651943 15933209 14722127 19720831 15388792 15702243 12915406 18805788 20577053
HNF4A WNT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10549281 20019092 22517624 16809766 22767186 19149881 15695365
HNF4A G6PC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12651943 11544200 15933209
PIK3R2 NRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
RPS6KA1 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11171059 11500364 14709557 20837011 15024086
WNT2 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23815780
WNT3 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18528331 15454084
WNT3A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22653731 20093360 22303445
WNT5A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20093360 21518267
SREBF1 ACACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12871210 23300015 20139635 11994399 22279139 11907029
PPP2R3B AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
RPS6KA2 EEF2K â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11500364 11171059 14709557 15024086
LEP LEPR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9463481 22405007 12226096 23331499 9207021 9218470 8608603 9786864
WNT3A DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
FZD2 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL3 WNT8B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT4 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12325120
WNT4 FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10557084 15265686 21541287
WNT3A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21128903 21665003
WNT3A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17117926 22753465 24032637
WNT3A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18215320 19910923
WNT7A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12857724 23331499 18567805 1285772412857720
WNT7A FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15705594
WNT5A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16273260 21903638 15578921 17804197 24032637
WNT5A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 2808370 9389482 19008118 24032637 19910923
WNT5A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16273260 21665003
WNT5A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 11029007 9054360
WNT2 FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18302287 24032637
WNT2 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19038973 24032637
WNT2 FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12138115 19038973
CAMKK2 PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
SREBF1 FASN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 10585876 16601238 20373869 11855808 20067991 18413311 12897158 11110846 17449569 18226595 16834571 15220339 17956315 12177166 19244231 17313375 16308421 23300015 11287605 17197698 11082286 11790787 12440974 10520861 17531980 18420801 18774944 11443121 16891625 20130133 20371699 18682402 22279139 18281474 21447637 11530940 22331133
SREBF1 SCD5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9705348 10400691 22510410
CAMKK2 PRKAG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
FZD2 WNT8B â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946