Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CREB1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721872 12658356
H3C2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
ALDH7A1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CREB1 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9926942 6548521
FOSL2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23339184 17434164
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
NCL BRCA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
VIM CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CREB1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RECQL5 CUX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
DDX42 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RECQL5 EEF1G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EEF1G RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ITGB3BP RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
MAPK8IP1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
MTSS1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAD50 NBN â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
PLK1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PLK1 TP53BP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 1000287 20126263
POLR2C POLR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C POLR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
VIM RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STAMBP RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RECQL5 TIMP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
VIM TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VIM TRIM28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAD50 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 10426999
POLR2D POLR2G â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
NBN FLNC â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
RECQL5 PLEKHA2 â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
POLR2I POLR2M â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
RECQL5 MT1G â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
RAD52 TCEAL8 â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
MED10 POLR2F â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
MED10 POLR2G â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
MED10 POLR2B â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
RECQL5 GPC4 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
RECQL5 CAV1 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
POLR2C POLR2M â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
PLK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31730000 25483079 29656893 24067368
RECQL5 DCD â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
POLR2M RECQL5 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
RAD52 TP53BP1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
MED10 POLR2C â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
PRKDC BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25223785 10608806
RPRD1B POLR2A â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
RECQL5 NOP10 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
MED26 POLR2D â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
POLR2E RPRD1B â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
MED10 POLR2D â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
MED10 POLR2E â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
BRCA1 MRE11A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MED26 POLR2E â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
POLR2G RPRD1B â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RECQL5 RPRD1B â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
POLR2A RECQL5 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
POLR2G RECQL5 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
POLR2C RPRD1B â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
POLR2D RPRD1B â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
POLR2I RPRD1B â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RECQL5 LCP1 â—¼   KO_UP_REGULATES ✅ + 0.87 0.87 PKG 28854368
PCNA TP53BP1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
FANCM RAD52 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
MED10 POLR2A â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10426999 29656893 10783165 11504724 25659039 25939603 25184681 19244116 18171670 12124328
POLR2B RPRD1B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
MED10 MED26 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
RECQL5 VAT1L â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
RAD51 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11498787 31270457 19369211 14636569 24085845 29656893 28319063 25659039 34408138 31009828 9774970 16713569 25499220 19766185 17302439 9008167 28976962
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14499622 25652403 17664283 19369211 14636569 24085845 29656893 34408138 11477095 9774970 16713569 21135251 25184681
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
PLK1 BRCA2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28985013 32286328 12815053 24835992 14647413 24448238
CAV1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23634843 11563984 22230296 19595769
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
RECQL5 NES â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
RECQL4 NES â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
FANCM MUS81 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
POLR2A RNGTT â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
RNGTT SUPT5H â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MED26 POLR2G â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
NBN RAD50 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
MRE11A TP53BP1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
RECQL4 MT1G â—¼   KO_DOWN_REGULATES ✅ - -0.94 0.93 PKG 28854368
PCNA POLR2D â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PCNA POLR2E â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
EEF1G UBR5 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
BRCA2 PLK1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
POLR2I SUPT5H â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
MRE11A NBN â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
FANCM TAGLN â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
POLR2A RPRD1B â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
RAD50 NBN â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 24981860 19197236 22939629 12679336 10426999 26344197 17526493 9705271 12607003 17612497 12447395 22464731 34348893 11062235 15758953 12124328 11238951 26215093 23530059 15734743 16391231 24651726 30179224 17500065 30440001 22941933 10783165
RAD52 RAD51 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 28551686 9826763 20190268 12750383 17118963 9837724 10666456 15766559 19338310 10212258 8550550 10448035
RECQL5 FLNC â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
POLR2D SUPT5H â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NBN ANXA1 â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
POLR1A POLR2F â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
RAD51 BRCA2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219969 17541404
POLR2A POLR2M â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
POLR2F SUPT5H â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2G SUPT5H â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2E SUPT5H â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
POLR2D POLR2F â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
POLR1A POLR2E â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
FANCC FANCM â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BRCA1 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MRE11A RAD50 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2C SUPT5H â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLR2A SUPT5H â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2B SUPT5H â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2C POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2C POLR2D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2G â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2E POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2F POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2G POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2B POLR2F â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
POLR2A POLR2B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2I â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2D â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2D â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2G â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2I â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2F â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2C â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2A POLR2G â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2A POLR2E â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2A POLR2F â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2B POLR2C â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2B POLR2E â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2C POLR2E â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2C POLR2F â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2C POLR2G â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2E POLR2G â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
POLR2F POLR2G â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PCNA RAD51 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA2 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA2 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA RAD51 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD50 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 BRCA2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 BRCA2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD50 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
CREB1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9528858 19882681 18160048 23447579 11704836
RAD50 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10783165 16260778 16391231 10426999 11504724 25084169 25184681 16713569
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
BRCA2 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA2 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA2 FANCC â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 15496928 15549137 15655342 16337602 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19793861 19793862 19841479 19847258 20021983 20064462 22266823
BRCA2 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA2 FANCC â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 15496928 15549137 15655342 16337602 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19793861 19793862 19841479 19847258 20021983 20064462 22266823
BRCA2 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
PLK1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 32286328 12815053
BRCA2 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 17145710 21601571 15937124 17541404 11313963 16914443 26145171 21670257 18264088 19303847 25585578 12815053 16793542 21789034 25282148 17515904 9126738 20729859 15703751 21076401 15065660 22293751 19875419 12606939 22116401 12619154 23935068 15800615 33476590 15800651 15671039 11477095 16513631 9811893 10551859 20729832 9523196 14636569 17515903 12442171 9405383 26833090 21399666 19628690 9560268 10373512 14580352
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
FANCM FANCC â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCC TOP3A â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCM FANCC â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCC TOP3A â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCC RAD50 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCM TOP3A â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCM TOP3A â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
PLK1 FANCM â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
FANCM RAD50 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
PLK1 FANCM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18931676 19270156 19622404 19680264 19686080
NBN TOP3A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
SUPT5H NCBP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
PLK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20126263 25607646 24703952
PLK1 VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 28390425 27603133 24196446 18056432 16260496 28953239
PRKDC TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19444312 27432546 23370278
TOP3A RAD50 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
RAD51 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RECQL5 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20348101 22645136
RAD52 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15766559 17145710 9826763 20190268 17118963 10666456 12750383 9837724 19338310 10448035 10212258
MUS81 LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.01 1.01 PKG 28854368
RECQL5 LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.02 1.02 PKG 28854368
RECQL4 VIM â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
RECQL4 FLNC â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
RAD52 DCD â—¼   KO_DOWN_REGULATES ✅ - -1.07 1.06 PKG 28854368
FANCM VAT1L â—¼   KO_UP_REGULATES ✅ + 1.07 1.07 PKG 28854368
NBN LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.08 1.08 PKG 28854368
TP53BP1 LCP1 â—¼   KO_UP_REGULATES ✅ + 1.1 1.1 PKG 28854368
RECQL5 AHNAK â—¼   KO_UP_REGULATES ✅ + 1.14 1.14 PKG 28854368
MUS81 FLNC â—¼   KO_UP_REGULATES ✅ + 1.15 1.15 PKG 28854368
NBN TAGLN â—¼   KO_UP_REGULATES ✅ + 1.16 1.16 PKG 28854368
TP53BP1 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.21 1.21 PKG 28854368
RECQL5 TAGLN â—¼   KO_UP_REGULATES ✅ + 1.24 1.24 PKG 28854368
MUS81 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.25 1.25 PKG 28854368
RECQL5 VIM â—¼   KO_UP_REGULATES ✅ + 1.26 1.26 PKG 28854368
TP53BP1 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
MUS81 LCP1 â—¼   KO_UP_REGULATES ✅ + 1.33 1.33 PKG 28854368
RECQL4 AHNAK â—¼   KO_DOWN_REGULATES ✅ - -1.37 1.36 PKG 28854368
MUS81 NES â—¼   KO_UP_REGULATES ✅ + 1.36 1.36 PKG 28854368
MUS81 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.4 1.4 PKG 28854368
RECQL5 RPS27L â—¼   KO_UP_REGULATES ✅ + 1.42 1.42 PKG 28854368
RECQL5 TCEAL8 â—¼   KO_UP_REGULATES ✅ + 1.45 1.45 PKG 28854368
RECQL4 CAV1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368
TP53BP1 DCD â—¼   KO_UP_REGULATES ✅ + 1.58 1.58 PKG 28854368
RECQL5 ANXA1 â—¼   KO_UP_REGULATES ✅ + 1.6 1.6 PKG 28854368
RECQL5 MT1E â—¼   KO_UP_REGULATES ✅ + 1.62 1.62 PKG 28854368
RECQL4 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.71 1.71 PKG 28854368
TP53BP1 FLNC â—¼   KO_UP_REGULATES ✅ + 1.72 1.72 PKG 28854368
RECQL4 ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -1.92 1.91 PKG 28854368
MUS81 VIM â—¼   KO_UP_REGULATES ✅ + 2.02 2.02 PKG 28854368
MUS81 MT1E â—¼   KO_UP_REGULATES ✅ + 2.44 2.44 PKG 28854368
RECQL4 RECQL4 â—¼   KO_DOWN_REGULATES ✅ - -2.61 2.61 PKG 28854368
MUS81 TAGLN â—¼   KO_UP_REGULATES ✅ + 2.84 2.84 PKG 28854368
RECQL4 TAGLN â—¼   KO_DOWN_REGULATES ✅ - -3.05 3.04 PKG 28854368
MUS81 MT1G â—¼   KO_UP_REGULATES ✅ + 3.46 3.46 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
NBN NBN â—¼   KO_DOWN_REGULATES ✅ - -6.31 6.3 PKG 28854368
RECQL5 RECQL5 â—¼   KO_DOWN_REGULATES ✅ - -7.08 7.07 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368