Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ERG AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8388477 22531786
SMARCC1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 18581278
GATA2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24423874
MYB AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12096342 18945670
HNF4A AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474850 12466965
AR SMARCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15923603 20610535
AR PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 20610535
YY1 CTCF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9756895
GATA3 ERG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21536859
ERG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25277175 20820186
ESR1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
MYB GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17641686
LHX2 PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19146846 24262147
MYB PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9371644 7838532
MYB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15082531
MYC SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24285714 24362264
NRG1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23966855 22757963
SMARCE1 SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18238828 19785031
SMARCA4 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
SOX10 SOX6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17084361
CTCF PARP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 14759373 20038529 19450526
SOX2 MTA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23667531 21532573
CHD7 SMCA4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20130577 21532573
CHD7 SMCE1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20130577 21532573
CHD7 SMRC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20130577 21532573
SOX2 SMRC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 35140242 21532573
MYC SMRC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
SMRC2 MDC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29656893 26344197
PPARG ASH2L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19047629 24368734
SOX2 ASH2L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30089852 35140242
BRD7 MYC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 35140242 20215511
MYC CHD7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 35140242 29467282
CHD7 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20130577 34079125
MYC CHD8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
PPARG RBBP5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19047629 24368734
RBBP5 SOX2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30089852 35140242
SOX2 TEAD1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 35140242 21532573
SMARCD1 SMARCD3 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
SMCE1 BRD7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 20305087 24981860 30940648 26186194 28514442 18809673
ARID2 SMRC2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 15985610 20305087 24981860 28514442
SMRC2 BRD7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 20305087 24981860 28514442 30940648
BRD7 ARID2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 24657164 24981860 26344197 30940648 18809673
WDR5 SOX2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30089852 29383478 35140242
MDC1 CHD7 â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
SMARCC2 SMARCE1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
ARID2 BRD7 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
ESR1 MTA2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18451880 16645043
MDC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
SOX5 SOX6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28514442 9755172 33961781
MDC1 SMARCC1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
ESR1 ASH2L â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16603732 21502505 31527615
ESR1 RBBP5 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16603732 21502505 31527615
SMARCD1 SMARCC1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
MDC1 SMARCD1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
CHD8 WDR5 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
LHX4 ARID2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 35140242 26186194
ASH2L CHD8 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24705355 20085832
BRD7 SMARCE1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SOX2 CHD7 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 28794006 23667531 21532573
CHD8 RBBP5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24705355 20085832
GATAD2A MTA2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MYC WDR5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31767764 35140242 17353931 29467282 30415952 27320920
BRD7 PBRM1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PBRM1 SMARCE1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GATAD2A MTA1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MTA2 MTA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21670149 34026424 24981860 26344197 12920132
ARID2 SMCA4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15985610 22140357 24981860 30962207 29374058 31043422
ARID2 SMCE1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 15985610 20305087 24981860 26186194 28514442 18809673
ESR1 BTF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18025262 31527615
CHD7 CHD8 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24705355 20453063
ERG PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24591637 21575865
ESR1 GATA3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26153859 23403292 25303530
SMARCD1 SMARCD2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ARID2 SMARCE1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ARID2 BRD7 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
BRD7 SMARCD1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MTA1 MTA2 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
SMCA4 PAX6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 35140242 16675956
MTA1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18451880 16807247 12167865 11146623 12639951 31527615
MYC SMCA4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14559996 17353931 29467282 11839798 30415952 28205554 28628118
SMCA4 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18451880 9099865 11003650
SMCA4 SMCE1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 30962207 22939629 16940996 29374058 16287714 12368262 9845365 20305087 26344197 12192000 18809673 14559996 28514442 8895581 11003653 26186194 31043422 20460684 19164553
SMCE1 SMRC2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 20305087 24981860 26344197 22939629 19650111 16199878 16940996 26186194 28514442 19164553 18809673 9845365
SMCE1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16538531 12145209 17363140 23403292 31527615
MYC BRD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19111069
WDR5 CHD8 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18378692 20085832 24705355 15960975
CTCF NES â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
YY1 MYC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 18490439 19219071 2191300
PAX6 PAX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10804178 11003833 12721955
SMARCC1 SMARCE1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 20829358
SMARCC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
ARID2 SMARCC2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
LHX4 YY1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
ARID1A SMARCD3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ARID1A SMARCD2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
ARID2 SMARCD1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SMARCC1 SMARCD3 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
SMARCD2 SMARCE1 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
SMARCD3 SMARCE1 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
SMARCC1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
SMARCC2 SMARCD2 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
ARID1A SMARCC1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ARID2 PBRM1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
SMARCC1 SMARCD2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
SMARCC2 SMARCD3 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
NLK MYB â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 15082531 15308626 16055500
SMARCA4 SMARCD2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SMARCC1 SMARCD1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
PBRM1 SMARCD1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
PBRM1 SMARCC1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SMARCA4 SMARCD3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
SMCA4 SMRC2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 24981860 23540691 30962207 22939629 29374058 18086889 12368262 11726552 9845365 20305087 26344197 18809673 15985610 14559996 28514442 9584200 8895581 10078207 31043422 20460684 22573825
PBRM1 SMARCA4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PBRM1 SMARCC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SMARCC1 SMARCE1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ARID1A SMARCD1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ARID2 SMARCA4 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
SMARCD1 SMARCE1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ARID1A SMARCE1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
ARID1A SMARCC2 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
SMARCC2 SMARCD1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ARID1A SMARCA4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SMARCA4 SMARCD1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SMARCA4 SMARCC2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCC2 SMARCE1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RBBP5 WDR5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCA4 SMARCE1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
MTA1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
ASH2L WDR5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L RBBP5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L WDR5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L RBBP5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
CTCF MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10625678 8649389 2284094 12032779 19568426 24725430 12524457 8246978 12897849 9591631 1795697
GATA3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17616709 20130088 20068169
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
ESR1 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26153859 25303530 10096242
GATA2 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19522008 22951020
GATA2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18522800 19772889 15896659
GATA3 YY1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 18533032 27062924 21151129 16009131 16087863 16980581 21934649 16113099 18358809 22056668 23172872 15282324 21878914 23192763
GATA3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18522800 15632071 15896659
HNF1B HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10518495 8290348 11585914 16479257
HNF4A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12591729 23714368 19966299 15024077
NLK HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
KLF8 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 11955436 11967263 12051714 15001769 15576399 16039586 17143292 17306568 17666529 17671186 17936032 19619488 19623618 20705860 21151179 21285352 22290435 22761862 23343194 24023259 25730849 7542250 8666229
MYB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18408764 19609274 8382794 1679531 1588953 1594249 9596659 11259163 8474446 2233716 16088151
NLK MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 15308626 15082531 12482967
MYC PPARG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
YY1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9797456 16314465 10528225 8266081 19279113 17287852 10713181 18490439 17434929 16878156 18542060
PPARG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11973610 17462534 16405739 19075513
MYC PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23277454 12695333
YY1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8266081 15805285 18490439 19219071 2191300
PAX6 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19666824 17825048 11358870
WDR5 RBBP5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
WDR5 RBBP5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
SMARCA4 SOX10 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10757804 16373334 17325040 23874858
SMARCA4 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 12917342 23540691 9891079 28420882
TEAD1 SOX10 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11394999 28852375 14664827 22492709 12056842 21411665 27288457
MDC1 TERF2 â—¼   KO_DOWN_REGULATES ✅ - -1.08 1.07 PKG 28854368
MDC1 NES â—¼   KO_UP_REGULATES ✅ + 1.17 1.17 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368