Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
YY1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21666725
SIX1 EYA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12783782 20110314
TP53 PAXIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
SSBP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19066201
STAT3 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15677471 23874455
TP53 KMT2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19433796 0902873106
PAX8 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8521821
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
GBX2 WNT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15790971 11124114
WNT1 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
WNT1 GBX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
WNT1 PAX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
YY1 KDM6A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
LHX2 PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19146846 24262147
KDM6A RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20123895
SIX3 PAX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11401394 9655819
CIC ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
HIVEP1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZNF609 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
TLE5 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZHX1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ZHX2 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN1 DLX3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NR2C2 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12169272 16157589
RET GDNF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15044950 11491658
PAX3 RET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19853745 21677782
PAX2 GDNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11731455 22552444
KLK6 HMG20B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PAX6 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23622063 15558475
KLK6 DCAF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FOXI1 SIX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17035528
SIX1 PAX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17035528
FOXI1 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12702667
NFIB WNT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31838646
NFIB NFIX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29106906
NFIX WNT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31838646
NFIA WNT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31838646
PAX2 PAX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704761 17166926
NFIA NFIX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29106906
GSE1 SNAI1 â—¼   PHYSICAL_INTERACTION 802.0 0.8 STRING 36370105
PCGF5 PCGF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22493164 24981860
DCAF7 BCOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 33722704
SIX1 TLE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16189514 12441302
CIC PAX6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29844126
CIC NFIC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29844126
CIC NFIB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29844126
CIC NFIX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29844126
CIC NFIA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29844126
SNAI1 GSE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
OSR1 VHL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15084514 12205091 16511565
PCGF1 MORC4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 27705803 27505670
DCAF7 PCGF5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 27705803 24981860
WNT4 WNT5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BBS1 BBS2 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 NCOA3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14578343 16860316
GDNF RET â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
TLX1 TLE1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 35140242 19250647
TLE1 TLE4 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TP53 WT1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
BBS4 BBS7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17574030 28514442 22500027 33961781 27173435 19081074 20080638
BCOR PCGF5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25416956 24981860 27705803
NFIB NFIA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 35140242 33961781 26871637
MAPK8 MAPK8IP1 â—¼   PHOSPHORYLATION 0.87 0.87 Signor 12756254
BCOR KDM2B â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BBS1 BBS7 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HMG20B SNAI1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
RET STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 25241761 11536047 12637586 15485908
BBS1 BBS2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17574030 28514442 22500027 33961781 27173435
BBS1 BBS7 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17574030 28514442 22500027 33961781 27173435 20080638
BBS4 BBS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17574030 28514442 22500027 33961781 27173435 19081074
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BBS4 BBS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17574030 22139371 22500027 25552655 27173435 19081074
BBS7 BBS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17574030 28514442 29039417 22500027 33961781 27173435 20080638
KDM6A PAXI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17178841 17761849 17925232 17500065 24981860 29785026
NCOR2 GPS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24943844 33961781 26186194 21240272
PCGF1 KDM2B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16943429 26687479 25533466 27505670 23395003 29985131 32628469 27705803 22325352 33961781 29502955 24981860
PAXI1 PAX2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 35140242 10908331
MAPK8 MAPK8IP1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
KDM6A KMT2C â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
FOXP4 FOXP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14701752 28507505 25609649 25027557
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
PAX5 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8521821 22105368 21319196
PAX2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8521821 16320598
TP53 MGA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
SIX3 WNT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12050133 20710043 20925119
PAX6 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350962 16189514 12756174
BCOR PCGF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16943429 26687479 27505670 27107012 32628469 33468080 26496610 27705803 22325352 33961781 24981860 23523425
PAX6 PAX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10804178 11003833 12721955
NFIC NFIB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 9099724 35140242 33961781 25258084
NFIB NFIX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9099724 35140242 33961781 26871637
NFIB NFIX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9099724
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BBS2 BBS7 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BBS4 BBS7 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
KDM6A KMT2D â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
KDM6A PAXIP1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
PAX6 MITF â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 16189514 11350962
BBS2 BBS4 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EYA1 SIX1 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
ZHX2 ZHX1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12741956 26496610
BCOR KDM2B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16943429 26687479 25533466 27505670 26496610 24981860 33722704 29502955
BCOR PCGF1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ATXN1 CIC â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
KDM2B PCGF1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BBS1 BBS4 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
BRCA1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
EYA1 SIX1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 15492887 28514442 32296183 11734542 12874121 33961781 26186194 15226428
SIX1 EYA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17035528 15226428 15492887 11734542 32296183 12874121
PAXIP1 PAX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10908331 17925232
MAPK8 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 23255093 17502367 21702955 19413330 11335711 9343414 23331499 15465816 12576423 11350938 20068231 12763138 9872331 18491316 18669648 10521505 18691976 20058876 15979846 14551213 10446219
RET STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10918587 9305919 8272872 12626508 15592455 24662939 23331499 17209045 12576423 11350938 18498667 11294897 12244095 16189514 25047660 17761947 9083098 25241761 12637586 8626374 15485908 9566874 11940572 11429593 14551213 11536047 11850821 15212693 9582023
STAT3 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15870198 16861352 25854163
STAT3 WNT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19424602 17203201
YY1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10787423 10634504 8816507 10505791 18391986
NFIA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12145335 10505791 10634504 8816507
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
WT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16713569 10744705 8389468
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
SIX3 WNT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20710043 12050133 20925119 20682799
YY1 IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10518827 16922677 10359895 17270283
RB1 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12588874 11118439
TLE1 SIX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12441302
PAX6 SIX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11069887 11069920 12072567
TLE5 SIX3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12050133 16713569 12441302
MAPK8IP1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 18286207 15141161 23331499 18486448 10490659 9733513 9933567 11700324 15998799 9235893 16840345 9922370 15314024 12756254
RET MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18669648 9312068 11062067 15911620 95141073 16153436 15755722
MAPK8 PAX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11700324
PAX3 MITF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10982026 22290434 10480898 19074888 19403660 9500554 19026785 20925909 11237412 10942418 10644012 21965087 21519923 11830592
MITF PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9466887 23610061 17277739 15978250
GDNF RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 23331499 14514671 8674117 9482105 23429478 9182803 22751117 25684228
POU2F1 IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509003 8120390 10359895 10491186
TLE1 TLE3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10485845 11934263 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
PAX8 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9388203 15961562 8414514 8861958
PAX2 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9916932 16631587 9178767 8760285 19342968
WT1 WNT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22465478 12082525 20161747 21871842
WT1 NPHS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16631587 15579507 21980157 15504938 23768159
PAX8 WT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9388203 8861958
NFIB NFIC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9099724 25258084 16189514
FOXI1 PAX8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15459102 15188428 12538519 15604103
TLE3 TLE5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11290324 15187083 9783587 11266540 8365415 9887105
TLE3 TLE4 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10485845 11934263 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
PAX5 TLE4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12153506 10811620
TLE4 TLE5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11290324 15187083 9783587 11266540 8365415 9887105