Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
H3-4 H2AZ1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 H2AZ1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
HDAC2 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18675384
RING1 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15386022
POLA1 PCNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
HDAC1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18691180 9650586
ATF1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7479004 9883884
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
H2AX H2BC9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AX SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
H2AX UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H2AX SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H2AX SMARCA4 â—¼   COLOCALIZATION 2.0 0.8 intact 7914327 20224553
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
SMARCA4 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7914327 20224553
SUMO1 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
BRCA1 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9008167 19146767
UBE2I H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H2BC9 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SUMO2 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
H3-4 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 HNRNPU â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 KIF22 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PRPF8 H2BC9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 TERF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 KIF4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 SNRPD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 CHD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 PARP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SMURF2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16950122
JUN POLD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10978529
RPA1 PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5222806 17673209
POLA1 PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM2 PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM2 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
PRIM2 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
PRIM2 PRIM1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
KIF4A KIF4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10747093 10804209
KIF4B HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
KIF22 KIF4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15326200 8599929
TOP2A RESF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
XPO1 AGO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
AGO2 XPO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
AGO2 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
DAXX AIRE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20185822
ARID1A H3F3A â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ATF1 TOP2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12104051
INCENP AURKA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19357306 0900833106
AURKA CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001737 24358021
AURKA TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 14702041 19121998
E2F1 AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20300951
INCENP AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16824953 19357306
AURKA INCENP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16824953 19357306
AURKA KIF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 30576375 31881080
INCENP AURKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218018 16239925
RACGAP1 AURKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
PARP1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16647857
E2F1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15033491
SF3B4 BCAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PRPF8 BCAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
BCAS2 SF3B2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
BCAS2 SRRM1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
BLM PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16864798 0601828103
ESR1 BLM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17268063
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
FOXM1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18408007
BRCA1 KPNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221252 8955125
JUN BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16229810 17434164
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
BRD4 VHL â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
MYC BRD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23792448 22904298
BRD4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32482868
PIN1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 9499405
HNRNPC CDC5L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CDT1 CDC5L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
PLRG1 CDC5L â—¼   PROXIMITY 2.0 0.8 intact 7945687 20467437
NUSAP1 CDCA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12963707
TPX2 CDCA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12389033
RACGAP1 CDK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
PIN1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11774038 16713569
CDK1 TPX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25688093 29052541
CDK1 RFC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12930972
E2F1 CDT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14990995
NPM1 CHD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
COPS5 TCEB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
COPS5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18926707
PIN1 CSNK2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11940573 5215253
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
CSNK2A1 PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20711232
SUMO2 CTBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20176810 20098713
SUMO1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12769861 12679040
SUMO1 CTCF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19029252
XPO1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19940019 18573912
DOT1L CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000539 21103407
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
CTNNB1 VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16983094 0606850103
E2F1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14706452 18794899
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CWC15 SRRM1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DAXX TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 14557665 5216762
HNRNPC DDX21 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SF3B2 DHX16 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
TOP2A DHX16 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
XPO1 DHX9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
JUN DHX9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22550165 18180292
PIAS4 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TPX2 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 DLST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17916908 21191025
TCF4 DOT1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000539 21103407
DOT1L TCF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000539 21103407
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
L3MBTL3 E2F1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0610279104 17517653
E2F1 KIF2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23610368 18440323
E2F1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18396012
E2F1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
E2F1 POLE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11433027
E2F1 TOP2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11313881
E2F1 TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7734951
E2F1 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24076372 18439978
E2F1 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 PPM1D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912047
FOXM1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346 17875680
ESR1 HMGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17922863 18414489
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
ESR1 PRKCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22430216 18414489
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
FOXM1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
ESR1 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085516
FBXL13 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MYC FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20638938 19366810
JUN FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460851 20638938
NPM1 FBXW7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18625840 28920929
FBXW7 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20571051
NPM1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219698 17318229
RB1 HDAC1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
RCHY1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16914734
PPP1CA HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17008050
UBE2I HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25704882 22493095
RB1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211419 10228159
SUMO1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25704882 22493095
MYC HDAC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697349
TP53 HMGB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547598 9472015
KPNA3 HNRNPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PIN1 HNRNPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
UBE2I HNRNPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SF3B2 HNRNPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
HNRNPC TCF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 HNRNPC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18296503 21317560
SNRPA HNRNPU â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPA8 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
INCENP PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19228686
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
JUN PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20444941 7841543
JUN PPM1D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20093361
TCF4 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21722264 19029143
PTPN11 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9405464 19706677
NPM1 KIF22 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
KIF4A KIF22 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15326200 8599929
KPNA3 MDM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16511560 5218386
RB1 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
MAGT1 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 MAPK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0508606103 16627622
PRKCB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8903320 10327068
PPP1CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
YWHAE MDM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16511560 5218386
MDM4 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 19521340 7290688
MEN1 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
MYC SNRPD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
MYC NOP56 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
MYC SMARCA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24285714 24362264
MYC VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11318876 10528192
RB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 7838535
NCBP2 NCBP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TP53 NDN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10713459 10347180
SRSF1 NPM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218180 16376875
NPM1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6541703 18259216
NR4A1 RPS6KA6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PARP1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
SUMO1 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19622798
UBE2I PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
SUMO2 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
XRCC5 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
TOP2A PIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11940573 5215253
RACGAP1 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19468302 1000111
PRC1 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1000110 19468300
RACGAP1 PLK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 1000110 19468300
PLK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 7266226 19833129
TP53 PLK3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11447225 11551930
TP53 PLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21394211 16581545
POLA1 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
POLA1 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
RPA1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17666013 9214288
PRIM1 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM1 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
TP53 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11375983
POLD1 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 10852724
POLE2 POLE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 32296183
TP53 PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 PRC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15531928
TCF4 PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAC1 PRKCA â—¼   COLOCALIZATION 2.0 0.8 intact 5218533 16628218
TP53 PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10614633 9895308
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
RCHY1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 5220017 17568776
SUMO2 RNF168 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
UBE2I RNF168 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SUMO2 RNF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RPA1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
RPA1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
SMARCA4 VHL â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
SMARCA4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11950834 33476981
SNRPD3 SRPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TOP2A SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18394993 25114211
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
SUMO2 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1004248107 20534433
TP63 TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22232078
TDP2 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21030584
TDP2 TOP2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21030584
XPO1 TOP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
UBE2I TOP2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12832072 10862613
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
XPO1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17268548 17891139
RBM4B SNRPA â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
SNRPA1 SNRPD2 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
BRD4 TCEB1 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
NCBP1 SNRPD1 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
DHX16 SRRM1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
SNRPA1 SRRM1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
CDC5L PPP1CA â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
PLRG1 SRRM1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
INCENP KIF22 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
CSNK2A1 TOP2A â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
GINS1 POLE â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CDC5L SRSF1 â—¼   PHYSICAL_INTERACTION 809.0 0.8 STRING 36370105
P53 LMNA â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 29568061 30419336 25144556
H31 HDAC2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 11850410 12626569 24722339
CTCF PARP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 14759373 20038529 19450526
PIAS4 VHL â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 20300531 24002598 20844582
SF3B1 SRSF1 â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
DHX9 SF3B1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
HIST1H3E UHRF1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
H3F3A UHRF1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
BCAS2 SFPQ â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
BCAS2 SF3B2 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
SF3B1 SRRM1 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
POLD2 POLD3 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
PRPF19 SRRM1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
CTBP1 H2AX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
H2AX HDAC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31504778 28242625
H2AX CTCF â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
VHL CSN5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15082527 12032852
CSN5 NCBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31950832 21145461
JUN P53 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 31182485
ESR1 H31 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
AURKB H31 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21397507 10949293 11756469 18477699 34079125
H31 TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20504901 34079125
TSP3 RFC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
3BHS2 TOP2B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
3BHS2 TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
F131B TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
F131B AURKA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
F131B PLK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
BMI1 AGO2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
ASB3 TOP2B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ASB3 TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ESR1 AURKA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 21761334
AURKA DHX9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25852190 23443559
BLM PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24239288 34079125
BMI1 LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26468281 34316702
BMI1 ILF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BMI1 NCBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BMI1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 20668194
BMI1 NCBP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BMI1 G3BP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BMI1 G3BP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 24457600
BRCA1 KIFC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26831064 29656893
BRCA1 KIF23 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26831064 29656893
JUN BRD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 31239290
BTF3 SRSF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33644029 26344197
MYC CDC5L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
CDC5L ECT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31586073 20467437
CDC5L LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25948554 20467437
CDC5L PLRG1 â—¼   PROXIMITY ✅ 0.82 0.82 mint 20467437 7945687
MYC CDK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
VCAM1 CDK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 CHD4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
ESR1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
MYC CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
RNF4 DAXX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32296183 29695423
VCAM1 DDX21 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
MYC DDX21 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
ESR1 DHX9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33731348 19805454 21182205 20348541
MYC ECT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
ERCC6 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32355176 16107709
VCAM1 G3BP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
JUN HDAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 17056544
HDAC1 RING1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26496610
HDAC2 ZBTB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33301849 26949739
MYC ILF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
VCAM1 ILF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
MYC JUN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
PARP1 JUN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25609649 24636898
VCAM1 LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
SF3B1 MYC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20936779 29467282
MYC PRKDC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RFC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC SF3B2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC RFC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RING1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC XRCC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RBP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
NCBP1 XPO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19262567 26673895
NOP56 TOP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12777385 34079125
XPO1 NR4A1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26673895 22427340
VCAM1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
PARP1 TOP2B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16794079 34079125
PRC1 SF3B2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30217970 31586073
VCAM1 RAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 RBMX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
RBP2 TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18394993 26344197
XRCC5 RFC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26344197 12393188
VCAM1 SFPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
SRSF2 XPO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939629 26673895
VCAM1 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
SUMO1 ZBTB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24654937 32296183
VCAM1 TOP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 XRCC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 XPO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 VDAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
CDCA8 KIF22 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
DAXX H3F3A â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
KPNA1 NCBP2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
SMARCA4 TCEB1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
CDCA8 INCENP â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
HIST1H3E KMT2E â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
H3F3A KMT2E â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
HNRNPC SRSF1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
SFPQ SRSF1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
AIRE HIST1H3E â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
CHD4 HIST1H3E â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
AIRE H3F3A â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
CHD4 H3F3A â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
PPP1CA RB1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
PCNA UHRF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26496610 30357346
H2AX LMNA â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25948554 20000738 23658700
H2AX XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20085707 21679440 18406329
H2AX ILF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 20000738 26186194
H31 TOP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29568061 20504901 34079125
HDAC1 CTNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 10958684 27684187 31130994 16204248 17412698 19166851
TSP3 TOP2A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
G3BP1 AGO2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26777405 29395067 25681748
BMI1 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 34316702 24457600 20668194
PLK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31730000 25483079 29656893 24067368
BRCA1 TERF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 25184681 29656893 34112789
MYC BRD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30415952 32416067 29172540
CDC5L BRD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31239290 32416067 20467437
SRPK1 CDK7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23602568 32707033
SRPK2 CDK7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23602568 32707033
CTBP1 CHD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 31041561 24981860
DHX9 TOP2A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15034300 12711669
DHX9 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 14704337 15723802 21679440
KIF23 ECT2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19468300 31586073 22750944
ESR1 SRPK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 31527615 21182205
ESR1 SRPK2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 31527615 21182205
HDAC1 ZBTB2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 26496610 23752268 28514442 33301849
JUN TOP2A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25609649 8387155
MYC LMNA â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MYC XPO1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29467282 17314511 26673895 32140074
VCAM1 PRKDC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 22623428 19738201
RBM4B TOP2A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ILF2 SNRPD2 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
PRPF19 SNRPA â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
HNRNPC SF3B2 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
SF3B2 SF3B4 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
DYNC1H1 SNRPD2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
HDAC1 UHRF1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CHD4 SMARCA4 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CSNK2A1 HDAC1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
DYNC1H1 ILF2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
HDAC1 SFPQ â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
POLA1 PRIM1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
BCAS2 DHX16 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BCAS2 SF3B1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
DYNC1H1 SF3B1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
NDN TP53 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
PARP1 UBE2I â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
SF3B2 SFPQ â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
H31 PCNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33029857 26527279
LMNA PCNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24623722 29753763 30419336
PCNA CCNB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28514442 8101826 33961781 7903056
PCNA TOP1MT â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BLM H2AX â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15364958 29523790
H2AX H31 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 26095369 31045206 20587414 20224553 29229926 23319141 16622419
GSK3B SFPQ â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30711629 20932480
TOP2A CSN5 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15126503 21254166
CSN5 CUL5 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30587576 31950832 21145461 11337588 31253590
P53 NFYB â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 16959611 15831478 23734815
P53 AURKB â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20959462 29340707
H31 LMNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25948554 30419336 26527279
SUMO2 BLM â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19471022 16524884 16620772 21693764
PRKDC BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25223785 10608806
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
CCNB1 CDK7 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 28514442 26186194 11113184
CDC5L SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19596686 20467437
ESR1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15961505 31527615
ESR1 SRSF2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 21182205
LMNA PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29568061 25948554 30419336 22412018
PRKDC PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20085707 16794079 21575865 9398855
SUMO1 PIAS4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20016603 15831457 16524884
PLK1 PRC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19468300 17351640 31586073
SMARCA4 TP53 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
SRPK2 SNRPA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 23602568 32707033
XRCC5 TOP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21679440 28415827
PIAS4 SUMO2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
NUSAP1 RANBP2 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
AURKB CDCA8 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
HIST1H3E SSRP1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CDC5L PRPF19 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
DAXX HDAC1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
H3F3A SMARCA4 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
PCNA POLE â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
PRPF8 SRRM1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
PARP1 UHRF1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 31964471 24782312 34079125
DAXX H31 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 28514442 25275136 23142979 33961781
BLM MYC â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 30415952 29467282 23750012
SUMO2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21147198 20016594 20016603 22689573 21693764
BRCA1 TOP2A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25184681 15965487
HDAC1 ERCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 31722399 26496610 26030138
PARP1 HDAC2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 34079125 16204234 20596014
SUMO2 PARP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19471022 25027693 32786267 19779455 21252943 21693764
TP53 PIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 12397362 5215850
TOP1 PRKDC â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15848144 28415827
SUMO2 RBP2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19471022 25027693 32786267 16524884 16620772 21693764
H3F3A HIST1H3E â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
AGO2 DHX9 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TP53 XPO1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
H2AX PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15613478 26095369 14627815 18406329 22184063 20085707 20356835
FBXW7 P53 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33961781 28514442 31940492 31346036
H31 HMGB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29568061 29721183
H31 HDAC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11850410 26496610 24722339 31874856 26527279
PIN1 CTNB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16713569 11533658
CTNB1 DOT1L â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20203130 21103407
ATF1 ESR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21217774 31527615
AURKA BRCA1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22110403 26831064 14990569
BRCA1 RFC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 25184681 10783165 16713569
PRPF19 CDC5L â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 19633697 7262047
CDC5L RBMX â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11101529 20467437
CDC5L SCAF8 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11101529 20467437
DHX9 JUN â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11823437 25609649
RING1 E2F1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11583618 27705803
ESR1 MEN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 16651450
PARP1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19470756 34079125 16204234 20596014
RACGAP1 KIF23 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 8397056 22580824
PRC1 KIF4A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15297875 31586073 23870126
SSRP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
SUMO1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19779455 15561718 23871147 15576338 19596686
PARP1 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20085707 34079125
PIN1 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 11940573 16713569
SUMO2 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19471022 25027693 19394292 18381449 32786267 21252943 20797634 21693764
SUMO2 TOP2B â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19471022 25027693 19394292 21252943 21693764
XRCC5 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20085707 12393188
INCENP TPX2 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
CDC5L SF3B4 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
DHX16 SNRPA1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
MRE11A RPA1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
CDC5L SNRPA â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
SF3B2 SRSF1 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
SRPK2 SRSF1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
TERF2 H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21044950 22157895 21824286
P53 HDAC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10777477 20388487 20190809 14976551 21344396 17827154 17805299 22493095
P53 XPO1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 29653964 23825024 18952844 17268548
CDC5L BCAS2 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 20467437 7945687
TPX2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22110403 25184681 29656893
BRCA1 MRE11A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BRD4 TOP2A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 30554943 32416067 31239290
CDC5L TOP2A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11101529 20467437
CUL5 TOP2B â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 21145461
DAXX HDAC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10669754 12140263
NOP56 DDX21 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26496610 12777385 34079125
NOP56 DHX9 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22939629 26496610 12777385
DHX9 ILF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23986595 22863883 22939629
G3BP2 G3BP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 26777405 24981860 29395067 26186194 28514442
HDAC1 VHL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
MYC HDAC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22286234 17314511 30415952 20195357
HDAC2 VHL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
MYC TOP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 30415952 17314511 29467282 20195357
PARP1 PIAS4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19779455 20696768
SRPK1 SRSF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21157427 23602568
SRPK1 SRPK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 21157427 32707033
SRPK2 SRSF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23602568 9472028 21157427 19592491 32707033
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
G3BP1 G3BP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
MRE11A TERF2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDC5L DYNC1H1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
DAXX UBE2I â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PCNA UBE2I â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BLM TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CDK7 E2F1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
COPS5 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HSPA8 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AURKA TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
NCBP2 SNRPD2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
RB1 SMARCA4 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
POLA1 PRIM2 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
HNRNPC SFPQ â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NCBP1 SNRPD3 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NPM1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PRIM1 PRIM2 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
SRSF1 TOP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 RPA1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CDCA8 INCENP â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
PPM1D H2AX â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20460517 20101220 20118229
UHRF1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15361834 22411829 31782885 17934516 19800870 20037778
POLD2 POLD1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 31449058
RING1 P53 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29187402 22907436
PLK3 P53 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10673501 11551930 11709713 12548019 16713569 16189514 12242661
PRKDC P53 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9765199 19918261 10470151 10713094 9363941 9744860 10601022 11551930 11709713 10951572 16713569 8940078 25362358 11751391 12756247 10673501 10747897 9679063 11883897 10608806
P53 TOP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8639538 11805286 16713569 10468612 18697815 32807901
P53 TOP2B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10666337 16713569
P53 SRPK1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21130767 32807901
H31 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 32937373 28190768 20080577 29568061 20504901 34079125
CTNB1 TOP2A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 17983804 16230076 27684187
CTNB1 FOXM1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 26912724 22014570
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25084169 29656893 26831064 10783165
CTBP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11751867 10196224 16713569 21102443 31636387
ESR1 BTF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18025262 31527615
CDC5L BZW1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11101529 20467437
CDC5L PRKDC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11101529 20467437
CDC5L PPM1D â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11101529 20467437
CDC5L SFI1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11101529 20467437
CDT1 CDK1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28514442 26186194 14993212 31160578
CDK7 ESR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10949034 31527615 15461668
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
RACGAP1 ECT2 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 18201571 6166552
ESR1 HSPA8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HDAC1 SMARCA4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PARP1 HMGB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28190768 29721183 34079125
MYC PLK1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29467282 27773673 30415952 17314511 33494392
SFPQ TOP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15848144 24981860 9756848
TOP1 SRSF1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12270705 9611241 15848144 20805487
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PRKDC TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
XRCC5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
BTF3 RPL10 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
FBXW7 JUN â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
RANBP2 SUMO2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
POLD1 RPA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
RING1 RNF2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC2 SMARCA4 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CDK1 CDT1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CSNK2A1 HDAC2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RCHY1 TP53 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
H2AX PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28796254 28242625 16377563 27728808 18406329 28514442 20000738 20085707 16522924
MYC GSK3B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16247449 20713710 19131971 21150319 31638140 29467282 11877389 33541412 14563837 8247524
CSN5 CUL2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21145461 19615732 22013077 22956996 19295130 18850735
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
SUMO1 P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16732283 23150668 15017387 10961991 18583933 21316347 15327968 23825024 17369817 23543742 15931224 16713569 19684601 15144954 11867732 23604351 12917636 17060459 15576338 15242646 19246003 23772552 16189514 20534433 22214662 20972456 10562557 10788439 16122737 20861261 32807901
CDK7 P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9315650 9840937 32707033 9372954
MYC P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21150319 30415952 28205554 28628118
P53 NR4A1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 23071566 17139261
P53 AURKA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12198151 30013191 23201157 26186194 28514442 14702041 21761334
P53 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17545634 26556313 10766163 16713569 21761334
P53 E2F1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24076372 11739724 8557038
P53 TOP2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10666337 32807901 16713569
P53 HDAC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 14976551 20075864 17827154 19011633 10521394 16697957 10777477 16107876 11099047 32494626 16959611 11313951 12426395 18765668 22266186 19303885 25241761 26539911 20633551
CHD4 H31 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31970415 24576085 32251276 32744500 21278251 26527279
H31 PRKDC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20080577 22404984 29568061 20504901 26527279
H31 XRCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20080577 29568061 20504901 26527279 34079125
ASB3 CUL5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 21145461 17353931 18187417 28514442 31253590 24337577
ATF1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16713569 10945975
HDAC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220405 21102443 16713569
HDAC2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
CCNB1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9244350 16713569 23246971 11278247
BRCA1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
BRD4 RFC3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12192049 30554943 31753913 32416067
CDC5L ILF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11101529 26186194 20467437
CDC5L SFPQ â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11101529 22939629 26344197 20467437
MYC CHD4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30415952 17314511 29467282
HDAC2 CTBP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17967884 11022042 18212045 16713569 10766745 28947780 31041561 16036112
SUMO2 DAXX â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22578841 19471022 19394292 32786267 16475184 17081986 21252943 21693764 28851805 21383010
DDX21 JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11823437 25609649
PARP1 E2F1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20133863 14627987
JUN ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17317669 16713569 23747343 11477071
HDAC1 TOP2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11062478 11136718
HDAC1 TOP2B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11062478 11136718
ILF2 PRKDC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9442054 17389650 20808282
PIN1 JUN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 29225075 11432833 16713569
MYC NOP56 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30415952 17314511 29467282 17353931
PLK1 PIN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10037602 9499405 16118204 16713569 16189514
RBP2 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24654937 15161980 18359863 12192048 22578841 16524884 19785004 19596686
TP53 RCHY1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 17568776 5220017
TP53 RCHY1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 17568776 5220017
SFPQ SNRPA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17507659 9848648 34133714 21566083
SRSF1 SRPK1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9472028 17517895 12565863 23602568 10196197
DAXX SUMO2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
PIN1 ZBTB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
COPS5 VHL â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CDC5L ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
CDK1 RB1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
DAXX TP53 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
AURKB CDCA8 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
KPNA3 NCBP2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
ESR1 H2AZ1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19515975 23108396 20023423
HDAC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14988403 11929879 16189514 16713569
H2AX BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18344987 12419185 26095369 20681793 19805520 18001825 31501894 26121674 10959836 12485996 18001824 19766185 11927591 34321665 29499138
H2AX PPM1D â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 20118229 071696 8288827
GSK3B P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12064478 14523002 21900206 16713569 14744935 12048243 16189514 11483158
MYC GSK3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PRKCA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
TP53 POLD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19861536
MYC POLD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
TP63 POLD2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19861536
POLD2 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16000169 10852724 16510448
PRIM2 POLE â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
CSN5 JUN â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20093369 10766246 25609649 10903862 16713569 8837781
CSN5 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11285227 16624822 28539160 24725084 16936264 17879958
PIN1 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17906639 16189514 12388558 21900206 16713569 12397361 12397362 21741598
BLM P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15806145 11781842 12606585 22653443 15364958 12080066 24239288 16713569 32807901 11399766
MDM4 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 31462704 10827196 19255450 22745160 23671280 31066983 10075736 10629057 11528400 15604276 24445145 19521340 19075013 12370303 30598450 21965653 19432880 16024788 31152661 21088494 22807444 17301054 30832340 17875722 16713569 20724842 28628118 16227609 30672125 25464845 25825738 22266850 24659749 20515689 21075307 20174603 18316739 17110929 20705607 10608892 24127580 29023092 26876197 24667498 9226370 18677113 27114532 28514442 22374672 17080083 8895579 12393902 29523541 32511789 30045945 19305137 23028042 18485870 11223036 26148237 25609649 19153082 26186194 21925390 28205554 23946421 28487147 15916963 12874296 25961923 27249653
P53 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14978302 9582019 14710355 21742769 18501503 9482880 14636569 9926942 16677609 26140185 19509300 15571721 16713569 16969499 31073355
P53 ERCC6 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22032989 7663514 16713569 10882116
P53 PLK1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15024021 19833129 22653443 16753148
P53 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12898523 14627987 9565608 32807901 16713569 9312059 23169665 15044383
H31 BRD4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19766566 30554943 29568061 32416067
TPX2 AURKA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 20360068 19357306 12177045 14580337 18773538 22110403 14600264 26186194 28514442 26831064
ESR1 AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21761347 21761334 18497064
PPP1CA AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11039908 11551964
FBXW7 AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15592418 33824269
AURKA PIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23970419
BLM TERF2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12181313 19329795 15229185
RING1 BMI1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22897849 19636380 27705803 34133714 9199346 34316702 16751658 29402932 22493164 22325352 16359901 15386022 32296183 9858531 24457600 25416956 16189514 20601937 19451220
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
MYC BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11916966 9788437 20215511 30415952 16713569 12646176 14612409
DHX9 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12592385 9662397 26831064 16713569
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
JUN BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25609649 12080089 16713569
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CTCF BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15252835 24725430 19466541
BRD4 RFC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12192049 30554943 32416067 31239290
MYC BZW1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
PLRG1 CDC5L â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11101529 33961781 26344197 17353931 14576297 20176811 29395067 22939629 28514442 11544257 20467437
TP53 CDCA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
CDK1 FOXM1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 18285455 19160488 15024056
CDK1 RANBP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26051540 17570479
CDK1 KIF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29771379
HDAC2 CHD4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21670149 28977666 26344197 24981860 21258344 9790534 22939629 11003653 9804427 12493763 23752268 32744500 30737378 10545197 26949739 9885572
PARP1 CHD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20693977 26565020
MAPK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19941816
UBE2I CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
SUMO1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
PRKCD CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25639486
CTNNB1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 21362399 21986938
SRPK2 DDX21 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 23602568 26167880
NR4A1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12947120 24706823
E2F1 FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21518729 22802261
E2F1 POLA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18347061 7929342
E2F1 ECT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21886810 19015243
E2F1 KIF23 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19015243
E2F1 RACGAP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21886810 19015243
E2F1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15014447 11491305
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
ESR1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15961505 24119295 18404132
TP63 FBXO32 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
TP53 FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23518350 19366810 12824889
TP53 FBXW7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31346036 12824889
FOXM1 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19276163 20379221 23037713
MYC HDAC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 34147029 22286234 26496610 30415952 18271930 17314511 18003922 24951594
MYC HSPA8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983916 12695333
TP53 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 31027880 18431400
JUN VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9468519 16271621
LMNA PRKCA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 22986494 8463284 8034666
LMNA PRKCB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 22986494 8463284 8034666
MYC LMNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MAPK1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
PPP1CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
MYC MEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MRE11A XRCC5 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7680889 10200487 9671466
NDN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26384308 24349431
MYC SMARCAD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15345217 9489489 23550155
MYC PRKDC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC POLE3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840 16403426
MYC RPL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333 11085504
TCF4 NR4A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NR4A1 POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TOP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15247263 15848144 34079125
PARP1 PIAS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19779455 20932475
PRKCA PIN1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
PRKCB PIN1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
PRKCD PIN1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
POLA1 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA1 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 8223465
POLE POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLE2 POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLE4 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 6693436 10801849 9405441
PRIM1 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRC1 RAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23444367 16431929 23716662
PRKCB RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29088742 11805327
PRKCD PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19737086 9774685
XRCC5 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26496610 22404984 15520013 21679440 26446488 26344197 17308091 15941674 28154079 16857680 20711232 19303849 20023628 15758953 20085707 10750018 10446239 33005030 9312071 28345663 12393188
RANBP2 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22578841 18359863 16524884
SUMO1 RNF4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24844634 23086935 29180619 32296183 15707587 24151981 24907272
RNF4 SUMO1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SRPK2 SRRM1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 23602568 32707033 26167880
VHL SUMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20844582 24002598 20300531
TP53 SUMO2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
VHL UBE2I â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20844582 24002598 20300531
SRPK1 SRSF1 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
KIF23 RACGAP1 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
TOP1 TOP2B â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
BCAS2 SNRPD2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CWC15 SF3B2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CWC15 SF3B1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
DHX16 SNRPD2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
DHX16 SNRPD3 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PLRG1 SF3B4 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PLRG1 SNRPD1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
PIAS4 P53 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 15383276 11388671 16713569
PLK1 CCNB1 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 11242082
CSNK2A1 SSRP1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
POLA1 POLD3 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ECT2 RACGAP1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SF3B4 SNRPD2 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
SF3B4 SNRPD3 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
POLD2 POLD4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
TOP1 TOP2A â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
H2AX SSRP1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 24981860 28514442 18406329 16522924
RNF4 SUMO2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
HDAC1 RB1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
PIAS4 UBE2I â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
NCBP1 SNRPD2 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
SF3B2 SNRPA â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
FBXW7 MYC â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
POLD3 POLD4 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
SNRPA SNRPA1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
AURKA INCENP â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
BCAS2 SNRPD1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
BLM MRE11A â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CWC15 PLRG1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CTNNB1 TCF4 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
GINS1 POLE2 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
SF3B4 SNRPA â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
SUMO1 JUN â—¼   PHYSICAL_INTERACTION 0.93 0.93 HIPPIE 11867732 15469925 10788439
POLE2 POLE4 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
BCAS2 SF3B4 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
PLRG1 SNRPD3 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
SNRPD1 SRSF1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
SRRM1 SRSF1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
SRSF1 SRSF2 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CHD4 HDAC2 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
POLE3 POLE4 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
TCF4 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
SUMO1 TOP1 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 24654937 11709553 12439742 15576338 12149243 19596686
TOP2B TOP2A â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 22939629 8710863
NFYB POLE4 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
SNRPD3 SRRM1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PRPF8 SNRPA â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
BCAS2 CWC15 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
H31 SSRP1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 33961781 15616580 29568061 28514442 26527279
RB1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6550000 10779361
SMARCB1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
KIF4A KIF4B â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
HMGB1 TP53 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
SNRPA SNRPD3 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
PCNA TOP1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
SNRPA SNRPD2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
BCAS2 SNRPA1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
CWC15 DHX16 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DHX16 PLRG1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DHX16 SF3B4 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PLRG1 SF3B2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DHX16 SF3B1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
POLE POLE4 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
SF3B2 SRRM1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
SNRPD2 SRRM1 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
UHRF1 H31 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 32428527 25281560 33097091 22064703 32144273 34079125 30392931 29506131 30639225 32609811 31018966 14993289 17967883 22096602
RNF2 BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16710298 5218667
BMI1 RING1 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7998286 20601937
CWC15 SNRPD3 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
CWC15 SNRPD1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
CWC15 PRPF8 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
CWC15 SNRPD2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
TP53 MDM4 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7290688 19521340
TP53 MDM4 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7290688 19521340
SF3B2 SF3B1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 12234937 28541300 26344197 10490618 24981860 22939629 21981285 32152280
SUMO1 TOP2A â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 12832072 10862613 19596686 18381449
CWC15 SF3B4 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
SF3B1 SNRPD1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
COPS5 CUL2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
DHX9 PCNA â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
AURKA TPX2 â—¼   PHOSPHORYLATION ✅ + 0.96 0.96 Signor 26240182
PRPF8 SF3B4 â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
GSK3B CTNB1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11251183 29045831 11835406 10228155 16365045 31286874 23602568 10074433 18687691 33431799 34352208 19061640 27902311 27684187 29568061 29789528 21743491 17318191 25897075 30923315 12051714 11818547 26359353 12114015 10330181 17510365 19107203 12000790 24451375 19303846 16039586 25241761 30181396 11193155 8638126 19576224 30711629
P53 HMGB1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 9472015 11748221 23063560 16713569 11106654 16189514
SUMO1 DAXX â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22578841 31879127 12150977 18583933 20972456 21816224 21474068 11112409 16475184 17081986 30958586 20927612 25409927 19465479 11948183 28851805 23395904 21383010
RB1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5219804 17380128
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 21670149 24981860 22939629 26496610 11102443 11919195 11777905 30737378 9885572 22416134 26344197 21258344 9804427 12493763 11287668 16713569 11466315 12920132 20388487 9790534 10581039 11739383 15987735 17894944 19182791 9150135 28514442 26949739 19041848 10444591 19703393 11804585 25241761 17956988 11564889 12032298 15451426 15297431 23752268 18059533 9520398
NCBP2 NCBP1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11545740 24981860 9933612 22939629 26496610 26382858 26264872 31448526 26344197 17190602 32814053 12374755 29997244 29101316 31467278 22365833 29395067 19668212 16189514 7478990 23665581 12434151
SUMO1 TOP2B â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 15161980 21110914 10862613 15561718 19596686
BMI1 RING1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
PRPF8 SF3B1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
AURKB INCENP â—¼   PHOSPHORYLATION ✅ + 0.97 0.97 Signor 12925766
POLE2 POLE3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
CDC5L SRRM1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
SF3B1 SNRPA â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
BCAS2 SNRPD3 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
AURKA TPX2 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
RANBP2 SUMO1 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
BLM RPA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
DAXX SUMO1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RANBP2 UBE2I â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ARID1A SMARCB1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PLRG1 SF3B1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PRKDC XRCC5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLE POLE3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
DHX16 SF3B2 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDT1 PCNA â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CWC15 SNRPA1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
DHX16 PRPF8 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
DHX16 PRPF19 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PRPF19 SNRPD3 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PRPF19 SF3B4 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PRPF19 SF3B2 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
SF3B2 SNRPD2 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CUL5 TCEB1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
CDC5L DHX16 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
PLRG1 SNRPD2 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
DAXX P53 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 21134643 12482984 15339933 21482821 25241761 16845383 27626385 12954772 15364927 23038753 16713569 28875283 32545337 14557665
BCAS2 PLRG1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
CWC15 PRPF19 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
PRPF19 SF3B1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RFC3 RFC1 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 9488738 14681455 26344197 22939629 18245774 8692848
SF3B4 SF3B2 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 32296183 24981860 10490618 25737013 22365833 22939629 16923959 7958871 25416956 16189514
SF3B2 SNRPD3 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
SF3B1 SF3B4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PCNA RPA1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ARID1A SMARCA4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC5L SF3B2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC5L SNRPD3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC5L SNRPD1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC5L SNRPA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
KIF23 RACGAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PLRG1 SNRPA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PRPF8 SNRPD1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PRPF8 SNRPA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PSMB5 PSMD14 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SF3B1 SNRPD2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SF3B2 SNRPA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SUMO2 UBE2I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PRIM1 PRIM2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
BCAS2 PRPF8 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC5L CWC15 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC5L SF3B1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC5L SNRPD2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NCBP1 NCBP2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PLRG1 PRPF8 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLD1 POLD4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PRPF8 SNRPD2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PRPF8 SF3B2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SF3B1 SNRPD3 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SF3B4 SNRPA1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SNRPA1 SNRPD3 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PCNA RFC3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLD2 POLD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLA2 PRIM2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
BCAS2 PRPF19 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC5L PRPF8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC5L PRPF19 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC5L PLRG1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PLRG1 PRPF19 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLA2 PRIM1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLE POLE2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PRPF19 PRPF8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PRPF19 SNRPA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PRPF19 SNRPD2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PRPF19 SNRPD1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PRPF8 SNRPD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B1 SF3B2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B1 SNRPA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B2 SF3B4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCA4 SMARCB1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SNRPA1 SNRPD1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SNRPA1 SNRPD2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SNRPD1 SNRPD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SNRPD2 SNRPD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLE3 UHRF1 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
BCAS2 CDC5L â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM4 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SNRPD1 SNRPD2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BMI1 RNF2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CCNB1 CDK1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
MYC H2AZ1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18414489 22055461 12695333 11085504
RNF2 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17636032 15386022
PCNA PARP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA POLD4 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD3 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD3 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD4 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD2 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA PARP1 â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BLM PCNA â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
PCNA POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
MYC PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7597041 18358094 22911891 18809243 1280813111085504 11085504
JUN PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22550165 19940138 1352831 15205327 23078099
E2F1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7623816 12782299 14618416 20580656 9389735 11133765 8903355 9649317 23078099 12468739 1261188
E2F1 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15510213 18319725 11491305
PCNA POLD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24022480 9038370 16510448
PCNA RFC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8999859 12400013 15225546 19285992 10353443 12192049 9649448 26496610 12045192 12171929 24958773 8861969 9092549
PCNA CDT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16407242 19231300 16362051 24423875 16482215 16407252 16861906
XRCC5 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
PRKDC H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 107.0 1.0 Omnipath 18454178 9488723 19321613 21930799 19305155 25487737 22819196 20493860 17570479 12607005 16673875 26976643 17723002 21151168 16039583 21514376 26438602 19049966 20368801 23916969 16935931 27919340 17923115 16061642 18438399 20157519 20461094 21690091 24253929 19531483 26960975 25168287 18758438 19268590 27813335 25690891 17210576 26748709 18406329 23972723 17412408 34429760 27551505 12692309 29221122 20703100 16861886 25070753 27332952 33691101 33863809 23653357 21283714 16788066 19781914 20205745 20860841 21389100 16148027 20116089 15610743 20192759 20224553 14627815 24893124 10734083 20488183 23185622 18157161 33945602 30573684 12766154 25699710 18755145 27738310 10477747 34504648 16820894 20356835 19014481 20713529 17525342 23671119 26114388 23355489 28790110 23678292 20118229 23166506 33986864 15604242 16377563 20609246 12907603 26119999 25072018 15289343 23891091 25269479 23620287 33731502 22972376 34282773 26578593
PPM1D H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20118229 20101220 20460517
RNF168 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19342239 22980979 31533041 18443409
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
GSK3B MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 18463697 21646472 30037819 26751215 25647305 2663470 20080742 19797085 30003124 16855632 12040186 18679417 11018017 23331499 29229669 16611981 21071413 24265759 20068231 10671551 16039586 17570479 16023596 29258530 12615961 18669648 21113395 22461507 19131971 8247524 16247449 20604938 19575820 15150404 22481935 23668310 19651622 17444818 23964270 20537194 22893788 27684546 24662831 25333250 20399964 11877389 14563837 18408012 17052453 18455992 15212693 16371461 11274345
GSK3B JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 23331499 1846781 25979842 25241761 20537194 21278055 21397588 17482134 1516134 8384355 17570479 16023596 17215518 30086763 92065884 24632621
GSK3B SFPQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20932480
GSK3B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9832503 17359287
GSK3B VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 16288047 23993956 29682501 18381814 25296756 21530686 22995655 26883165 19720099
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
XRCC5 H3-4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TP53 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23677994 19501055 18220474 21382456
E2F1 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24453336 12838312 15361834 23023523
UHRF1 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10646863 12530060
POLD4 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLA1 POLD2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD3 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD2 POLA2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD2 PRIM2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD2 PRIM1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD4 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD3 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLA2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 PRIM1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 PRIM2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 9286699 12403614 16510448
POLD1 PRIM2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
PRIM2 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
PRIM2 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 PRIM2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRIM2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRIM2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 TCEB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 TCEB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
MYC GCN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20936779 17353931 17314511 17093053
CSNK2A1 ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 20730097 9685505 8663317 18452278 18669648
BRCA1 AURKA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 AURKA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
MYC AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20890087 20519624 14744757 20682043
AURKA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22864622 22340593 18026198 24775809 14990569
AURKA PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 18566290 23618492 27721411 24338364 15713655 28126323 34260926 19364923 33805672 33771996 32284347 27504491 33898950 10980711 26206521 21474997 32060423 27662907 28994651 33963314 18615013 23695676 34197606 18669648 25925375 26114094 19228686 28591578 22281053 18691976 20603326 15611664 27068477 27908669 26919439 26012549 18477460 34140642 25660017 27899378 19369195 21454580 25871386 24349352 12207013 20869364 11854496 20633640 28351953 24667170 25042804
AURKA TPX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15630414 14600264 18773538 26186194 17145710 20360068 14580337 26240182 19357306 12177045 22110403
AURKA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 24173284 22864622 25217103 24089029 16713569 19413330 25848977 17999753 23565200 25333414 23201157 16552184 10884347 1956339 26186194 29455673 15469940 15749021 18974145 21502403 17287340 28043820 22396649 92065884 12198151 27933271 22852086 12064478 30266789 25398437 17259342 22350019 25634113 14702041
AURKB INCENP â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 12925766 14722118 14767480 15249581 16571674 17199039 17956729
AURKB INCENP â—¼   SHARES_COMPLEX 7.0 1.0 ACSN 12925766 14722118 14767480 15249581 16571674 17199039 17956729
AURKB INCENP â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 12925766 14722118 14767480 15249581 16571674 17199039 17956729
FOXM1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15817462 15689977 17173139 16314512
AURKB KIF20A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27939310
AURKB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 20959462 27933271 20847049 15469940 32873634 22611192 27496712
AURKB RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 27496133 27933271 19225156
AURKB KIF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15630414 26148251 14972678 14960279 17567953 19632184 15064354
AURKB INCENP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 18773538 20619651 26460953 16565220 21554500 19303298 18477699 33067654 27332895 22024163 15316025 24344188 20068231 19357306 22814604 19951914 15249581 25892238 16571674 27512725 11050385 12925766 18669648 15630414 18767990 18691976 17956729 20562864 21051298 32028528 19369195 19995937 20739936 16239925 32356865 20430883
AURKB KIF23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15630414 30728176 16461284 25512391 19203582 15854913 20451386
AURKB RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15630414 14744859 19007248 17178910 19555392 18201571 17287340 12689593 15108802 18669648
AURKB KIF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28992084 31881080 23940115 25512391
BLM TERF2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 23253856 24089143 24095737
TERF2 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 15229185 19329795 12181313
BLM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12080066 11399766 22653443 24239288 15806145 11781842 16713569 15364958
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
BMI1 RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16710298 22493164 22902369 20068231 22325352 25355358 17157253 16751658 26496610 16714294 26468281 26151332 12183370 12589020 21772249 25843776 20601937 32296183 21676867 27647897 15563468 27705803 16359901 24457600 19636380
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 SFPQ â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 SFPQ â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 RB1 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
PPP1CA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 25056273 12438214 17511879 17603999
CDK1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9244350 21706030 10550055 17570479 19683496 16713569 26745677 32193285 26719576
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
LMNA CCNB1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 22986494 2188731 2344612 2188730
FOXM1 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11572993 19276163 15671063 11682060 19097132 23812424
TP53 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12874009 14627709 10051609 11313928 17942917 11892838 15710382 20395210 19470724 12379461 11071927 11522645 15737644 11162602
MYC CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 11522645 11983916 19470724
CDK1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23799914 34224728 20117088 16784539 24358021 24508230 19470789 10973963 17283331 20228808 18347064 11242082 12397081 10362260 24582498 15582998 20367638 1833185 12447691 9001210 2570636 24101512 23543736 11331587 12524548 22726437 27626412
FOXM1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15817462 15689977 10567581 11572993 11682060 15024056 11391529
PLK1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 20404109 16854412 26899266 19364923 25362646 20126263 12524548 26729093 11242082 12447691
E2F1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15510213 7575488 18590585 17303408 18319725 17660363 15279786
CDK7 CDK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11900249 12648680 15703371 16697054 17386261 17884153 19667075 19809470 19847258 7533895
LMNA CDK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 22986494 2188731 2344612 2188730
CDK1 RB1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 CDT1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 PLK1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 7575488 9892021
CDK1 RPA1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
TP63 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11593387 19861536
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
E2F1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15510213 7623816 14618416 12760745 11799067 8137237 12629169 17108174
MYC CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18802399 2237430 8065306 11085504
CDK7 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 85.0 1.0 Omnipath 16565220 18767875 11113184 33657372 27303922 19690332 19667075 15703371 10913154 14988404 1532335 29793495 20360007 7799941 19158392 19664995 33574676 19809470 8548828 7533895 17386261 34489572 26881937 17554681 20068231 18452278 21900495 18669648 12814430 16327805 18691976 15868411 8441405 21778139 25849598 27908669 12459251 1833185 19651622 22263797 19847258 19707596 17924679 20347419 29435156 18220336 34370741 19369195 22505032 21468563 17884153 12663041 22425727 7944411 12648680 11900249 8344251 16697054 31429764 24970150
CDK1 NUSAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22101338
CDK1 KIF22 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12727876 27550518
CDK1 LMNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 19007248 16565220 20166139 17081983 18767875 20393185 23870088 17137347 19413330 18187866 19194518 30190500 19664995 19415658 15302935 7925482 16083285 95010153 24741066 20068231 18452278 18077418 17570479 18491316 18669648 32071079 23427156 2344612 18691976 26922519 17287340 18815303 20068230 19651622 20058876 19691289 17924679 22367880 19165338 19664994 18707149 21389115 16964243 18212344 24556839
CDK1 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 17303408 19690332 15084261 19413330 19664995 15279786 7575488 21249227 92097548 20068231 18669648 18590585 1756735 17660363 19651622 20058876 18220336 10542199 19664994
CDK1 ECT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21189248 16170345 22172673 22898780 18669648 16247472
CDK1 INCENP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26460953 20427271 25798441 28314740 29971233 19303298 21149564 26528436 20633640 16378098
CDK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 17274640 22367880 18088087 17202132 9122166 97225924 10880350
CDK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7592773 30392930 18691976 19387552 20068231 96029687 16371510 1400350 19941816
CDK1 PRC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29484112 18691976 22621898 17351640 17438553 17512944 16603632 30992425 20633640 23940115 9885575 16964243 27551054 34158398
CDK1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15735705
CDK1 KIF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20368358 29230353
CDK1 NPM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 17081983 12058066 27253419 22285574 25908633 20333249 16912078 27553022 19933706 16083285 20068231 27619510 17570479 18669648 7213797 81161106 26536659 11278991 17287340 17924679 15190079 14670079
CDK1 PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17764786 17660363 15279786 15917306
CDK1 FOXM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23240008 19737929 28387346 19160488 15024056
CDK1 KIF20B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470801
CDK1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7575488 18590585 17303408 8087847 27175585 17570479 17660363 15279786
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 30257348 10949034 15461668 9528769 22879364 12118371 28423697 27748765 15059947 16076840 7491495 12093745 23850489 15528270 7838153
CDK7 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23397142 10428966 17050006
CDK7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17591690 11709713 12064478 1088347 16083285 9372954 11483158 9620776 10348343 10884347 16552184 9315650 11007451 9571186 10747897 17898864 1454855 11585729
RPA1 CDT1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 CDT1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 CDT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
E2F1 CDT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18319725 14990995 19541929
COPS5 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25609649 20093369 18926707 10766246 16713569 8837781
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
CSNK2A1 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 19007248 16565220 17081983 18767875 19664995 15302935 10942766 19098900 20068231 18452278 7499337 9761967 18669648 8939955 18691976 17287340 19651622 20058876 19691289 9804834 19664994 11940573 7961967 16964243
CSNK2A1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17287340 19413330 22113938 18669648
CSNK2A1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 19007248 16565220 20166139 17081983 20230923 25609639 19413330 19415658 20388487 20068231 18452278 18669648 18691976 17287340 12176973 19651622 12082111 19691289 24526703 18510355 18212344
CSNK2A1 SSRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 19007248 15659405 20068231 17287340 22113938
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2A1 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21474068
CSNK2A1 HNRNPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19651622 20058876 17081983 20166139 15687492 18691976 20068231 18452278 19664995 17693683 17287340 19413330 12564933 18669648 15302935
CSNK2A1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 25609649 1846781 11948398 15378002 12531896 19413330 8654373 15302935 11075956 12628923 11896587 1516134 8464713 11971971 1651323 8137421 9685505 91332050
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
CSNK2A1 G3BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 27022092 33065005 32302571 32302572 12642610 27083003 23163895 11604510 31171631 27920254
CTCF MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10625678 8649389 2284094 12032779 19568426 24725430 12524457 8246978 12897849 9591631 1795697
MEN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19737400 9694656 10473551 19079338
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
CTNNB1 TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12086873 11943708 13679048 15806138
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
PIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16713569 11533658
SMARCA4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11532957 14964309
RAC1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19751508 28626389 26403202 19417647 22270359 16212495 16940750 12480336 11152757 29497040 30650643 19020303 15377999
CTNNB1 TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 24532795 11713475 18281465 25402006 16724116 12799378 12944908 12727872 23331499 15060161 17412698 22080605 21743491 17875931 12657632 17983804 20126258 17318191 24798214 24876153 29361949 17909039 23449499 22699938 18595660 9308964 16007074 15331612 11713476 15665104 17072306 15525529 17962194
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
RIPK1 DAXX â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 DAXX â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 DAXX â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12954772 21482821 21134643 16845383 25241761 15364927 16713569 12482984 15339933 23038753
DDX21 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11823437
E2F1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
E2F1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11533237 16081466 16738312 16188218 15618023 14681231 16230367 15985428 8264596 18583990 16601104 14627987 15016799 11268000 10490838 11818069
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
NDN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24392139 9422723 14593116
PARP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14627987 20133863
RB1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 17145710 23472054 12502741 22078878 8896460 12397079 9315635 20839231 16249186 11839806 8255752 11713253 20871633 15837424 8346196 19249677 16360038 8626527 12096339 15485814 16374512 18391203 9125176 16766265 9468140 8816798 12598654 10393912 9400991 9632788 12947005 19477924 15485920 17380128 10523633 10869426 7828850 18216119 8657117 12963846 25257171 17488475 28074012 15670817 11583618 7739537 10499802 8413249 11090181 8230483 22768064 29521627 10207050 9553123 7958924 11420730 23001041 16496386 9501179 19058874 1388726 9422723
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
PLK1 ECT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17332740 18669648 16247472
ERCC6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16713569 10882116 19221478 18784753
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
SSRP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15171726 23810005 1406642 19946334
ESR1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16574784 18006642
ESR1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11477071 17963131 10037443 16679312
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
JUN ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
ESR1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11477071 17317669 16713569
FBXW7 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14739463 28036276 18930588 16023596
FBXW7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15498494 17145710 32047362 28007894 31569395 33821962 20399964 20970423 17157259 16023596 20852628 15103331 15150404
MYC FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20658516 18798339 12695333 17341548
FOXM1 PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15817462 16314512 16809346 17173139 15531365 15654331 15689977
FOXM1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17141659 10567581 17655499 16965535 11391529
UBE2I HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11960997 12032081 15199155 24068740
SUMO1 HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11960997 12032081 15199155 24068740
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
UBE2I HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12820959 15340381 11960997
HDAC1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
TP53 HMGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
HMGB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
PRKDC HNRNPU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 27303920 25986610 19351595 25030905 19844162
MYC IGF2BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21779431 18414489 21252116
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
JUN TCF4 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 12051714 15001769 15082531 15377999 15576399 15766563 15768032 15806138 16007074 16039586 16169192 16510874 16940750 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19020303 19619488 19623618 19751508 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22270359 22290435 22699938 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN TCF4 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 12051714 15001769 15082531 15377999 15576399 15766563 15768032 15806138 16007074 16039586 16169192 16510874 16940750 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19020303 19619488 19623618 19751508 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22270359 22290435 22699938 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN TCF4 â—¼   ENZYMATIC_REACTION ✅ 49.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 12051714 15001769 15082531 15377999 15576399 15766563 15768032 15806138 16007074 16039586 16169192 16510874 16940750 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19020303 19619488 19623618 19751508 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22270359 22290435 22699938 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN TCF4 â—¼   DOWN_REGULATES ✅ - 49.0 1.0 ACSN 10391247 11274345 11929833 11955436 11967263 12051714 15001769 15082531 15377999 15576399 15766563 15768032 15806138 16007074 16039586 16169192 16510874 16940750 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19020303 19619488 19623618 19751508 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22270359 22290435 22699938 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
JUN NR4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18163434 19751824 16264271 20847229 7969116 8413214 10772826 10567637
UBE2I JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11877416 16713569 16055711 10788439 8733011
PLK3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17804415 21296815 19690332 19413330 18650425 18669648 15302935
RB1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10026157 9545246
PIN1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 11432833
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
JUN TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16007074
KIF4A PRC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23870126 15297875 15625105
PRKCA LMNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17081983 16565220 20166139 18767875 19562805 19413330 8477740 19664995 12112001 19415658 7925482 16083285 95010153 20068231 18669648 18691976 19651622 19691289 17924679 18707149 93238752 16964243 18212344
NPM1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
PRKCA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11704645 12598525 19074803 8903320 9160888
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11883936
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23597856 26637332 16627622
TP53 MDM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16492744 18172009 21750655 20036872 21422812 17510313 9926934 18336191 19521340 20372076 10469568 20080970 22290440 21394211 23474762
MDM4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 25609649 18677113 28487147 24445145 30045945 20515689 26148237 22266850 11528400 19521340 21088494 16713569 15916963 9226370 12874296 21925390 16024788 25825738 24667498 16227609 24127580 8895579 20174603 18485870 12963717 15604276 25464845 12370303 10608892 23028042 25961923 26186194 17110929 22374672 26876197 17301054 23671280 21965653 17875722 22807444 10075736 19305137 17080083 29023092 27114532 20724842 10827196 19255450 24659749 28035068 23946421 20705607 19075013 21075307 12393902 11223036
NCBP1 METTL14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
NCBP2 METTL14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
TP53 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21611785 11713584 10365096 15217513 16258956 14675138
MYC PIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC PIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
TCF4 MYC â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 7542250 8666229
PLK1 MYC â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
TCF4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21533051 19778454 15928669 20133699 18852287 19561604 19662654
MYC NPM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15589822 16857742 14519204 23271972 11983916 11085504
MYC PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23277454 12695333
MYC SRSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12747840 22545246 23935626 18414489
MYC VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22286234 12695333
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
SMARCB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10319872 14559996 14964309 19234532
TCF4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
PIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26655473 15048125 30723410 23716601
PLK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18931676 19270156 25915540 23887393 19622404 19686080
NDN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24722188 10347180 16713569 23785149
TP53 NFYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 16959611 11096075 15831478
PLK1 NPM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19651622 17081983 20068231 27619510 15190079 20352051 19413330
NPM1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 23443559 15144954 16740634 15310764 16376884 12080348
NR4A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23071566 17139261
PARP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9312059 17891139 15044383 12898523 14627987 16713569 9565608
PARP1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9563011 9518481
PARP1 TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 20875401 15911331 15848144 14699148 15247263
PIAS4 TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12727872 20211142 15831457
PLK1 PIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 27618008 23633483 16118204 9499405 16713569 25070718 25766872 10037602 22926167
PIN1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12397362 12388558 17906639 12397361 21741598 16713569 24982848 21900206
TP53 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17172872 17981789 15024021 22405092 20962589 24076372 23948487 15016801 22184120 19713933 16369493 23474762
PLK1 RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 28692064 17081983 16565220 27453045 19007248 19468300 25486482 19468302 19690332
PLK1 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 25328138 8939955 11699638 19098900 18062778 18171681 7499337 7961967 29915179
PLK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22653443 19833129 16753148 23948487
PLK3 TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18062778 17081983 18669648
PLK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 15489221 24395704 11709713 10801407 15254178 16581545 12242661 16713569 12111733 11551930 19607708 10673501 11875057 11447225 12548019
POLA1 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA1 POLD1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLA2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA2 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA2 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 POLA2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD4 POLD1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 PRIM1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD4 POLD1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 PRIM1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 12403614 16510448
PRIM1 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD4 POLD3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD4 POLD3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
PRIM1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD3 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRIM1 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
PRIM1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
TP53 PPM1D â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18333294 19015127 11101524 22405851 20093361
PPM1D TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15870257 17936559 23666059 28903382
PPP1CA RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 12202491 8380224 17274640 10773440 9315635 17008050 20694007 8384581 16189514 8380637 10889204 12434308
PPP1CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16501611 16713569 15231748 15178317
PRKCA RAC1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10679481 10871288 16492141 18851840 20027184 21474067
PRKCA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18812399 9935181 15659650 9315650 19933256 16713569 9571186 1454855
PRKCA PRKG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17570479 12609995
PRKCA PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16055440 11781100
PRKCA RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16628218 20027184 11284700 18851840 21474067
PRKCB TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19007248 12569090 19691289 17081983 8939955 96081879 18691976 9804834 7499337 11940573 15212693
PRKCD TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17906639 16314418 16377624
PRKCG TOP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 19007248 12569090 19691289 17081983 96081879 18691976 7499337
PRKDC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 15355354 19398950 15254178 9372954 11483158 7862459 16713569 11875057 11551930 11883897 12548019 25168287 8502477 11709713 10446957 28145533 22726545 24886358 16552184 12242661 17570479 10196661 10747897 9885574 10673501 12091386 22355272 9765199 15489221 9561848 10801407 22504299 22444248 15177184 11042698 10358069 10470151 10606744 9744860 16397295 12959929 12064478 27130668 10951572 12111733 25937999 15381073 28102346 9363941 19918261
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
RCHY1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 21988832 19483087 17568776 24367557 25116336 21084285 12654245 21791603 20452352 19043414 16713569 31630802 27519799 19918835
XRCC5 RNF168 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
SFPQ TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 9756848
SMARCB1 SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 18414052 23540691 20506188 8895581 31759698
SRPK1 SRSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 8798720 18155240 8208298 23602568 10390541 9472028 17517895 10196197 12565863 21045158 24449914
SRPK2 SRSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23602568 9472028 16189514 10196197
TOP1 SUMO1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12149243 11709553 25114211 10759568
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
TOP2A SUMO2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24782567 17183683 18381449 25114211
TCEB1 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TCEB1 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP53 KDR â—¼   KO_UP_REGULATES ✅ + 1.12 1.12 PKG 28854368
ERCC6 ERCC6 â—¼   KO_DOWN_REGULATES ✅ - -1.24 1.23 PKG 28854368
TDP2 TDP2 â—¼   KO_DOWN_REGULATES ✅ - -2.0 1.99 PKG 28854368
POLE3 POLE3 â—¼   KO_DOWN_REGULATES ✅ - -2.96 2.95 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
POLE3 POLE4 â—¼   KO_DOWN_REGULATES ✅ - -5.81 5.8 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368