Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
EED RACK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080539 0908486107
RACK1 EED â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080539 0908486107
TP53 RACK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
CDKN2A MTA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1018389108 21555589
TP53 MTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23552838 22286760
MTA1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24424621 18719363
UBE2I H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H3-4 H1-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 YY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16774833
TP53 BARD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14636569 15782130
AURKA AJUBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15630414
PRKACA AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VIM AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 ANLN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1301998
UBE2I ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
MDM4 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15788536 16163388
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
ATM SMC1A â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 11877377 5215162
TIMELESS ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19996108
ATM HERC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20023648
AURKA CCNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001737 24358021
AURKA TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 14702041 19121998
BIRC5 AURKA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19357306 0900833106
AURKA KIF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 30576375 31881080
RACGAP1 AURKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
AURKB BIRC5 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19357306 0900833106
TP53 BRCA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003689107 20421506
NCL BRCA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
BUB1B HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7299731 19407811
CALM1 CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10770941 7642608
UBASH3B CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15159412
CCNB1 CDCA5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21878504 21987589
CCNB2 CDCA5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21878504 21987589
CCT7 PER1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 CDC20 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532 17873905
TP53 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532
PRKACA CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YY1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22025288 18558095
VIM CENPU â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CHEK1 MDM4 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
TP53 CHMP4C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 CHMP4C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302216
UBC CYLD â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
MAPRE3 DCTN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
VIM DES â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GFAP DES â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DES VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32296183 27107012
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
HSP90AA1 GFAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9038169 9151685
VIM GFAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GFAP LNX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GFAP PER1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC3 MECP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23770587 23770565
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
TP53BP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16945145
RANBP2 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12032081
PPP2CA HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18045992
PRKDC HERC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20023648
VIM KIF20B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17015431
TP53 MAP1B â—¼   COLOCALIZATION 2.0 0.8 intact 18656471 6700545
MAPRE3 MAPRE1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
MAPRE3 MAPRE2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
UBE2I MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
MDM2 MDM4 â—¼   COLOCALIZATION 2.0 0.8 intact 17159902 5219425
RASSF1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18566590
MDM4 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 19521340 7290688
MECP2 PER1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118894
SMC2 NCAPH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17268547 5219584
SMC4 NCAPH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17268547 5219584
TP53 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22103682 8291914
RHOA NCL â—¼   COLOCALIZATION 2.0 0.8 intact 21281639 8086571
NCL RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15743838
UBC NPM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6541703 18259216
YY1 NPM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16170350 9092633
PPP2CA RACGAP1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
TP53 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
TP53 PRC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15531928
TP53 PRDM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
UBE2I RAD50 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
RAD50 RANBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
UBC RHOA â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5217531 15710384
RPA1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
SKA1 SKA3 â—¼   COLOCALIZATION 2.0 0.8 intact 19360002 7275418
SMC4 SMC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17268547 5219584
TOPBP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18923429 7296625
TOPBP1 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 8086392 20871591
XPO1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17268548 17891139
UBE2I TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
VIM TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YY1 TP53BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
VRK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22621922
UBC UBASH3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17599067 5220070
ZBED1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
YY1 UBR5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
ASH2L HIST2H3C â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
RAD50 ATM â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 18854157
ATM RAD50 â—¼   PHOSPHORYLATION 0.8 0.8 Signor 17570479
CYLD UBC â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
MDM2 CDKN2A â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 7989562 20713054
PHB2 HDAC5 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 21081666 15140878
PER1 TIMELESS â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CCT7 CDC20 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
HIST2H3C UHRF1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
KLHL13 KLHL9 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
ZBED1 MBD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MTA1 SIN3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24981860 12920132
BARD1 AURKB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22350409 19176389
ASH2L UBR5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
CDC20 AURKA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 10377410 22340593
BUB1B HDAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28985013 19407811
NUF2 CASC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
MOV10 CDC20 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22658674 29395067
NINL DCTN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27173435 26485645
MECP2 DDX54 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MOV10 EDC4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22658674 29395067
EED NOC2L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 24457600
KIF2C KIF2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
KIF2A SKA3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33106477 34079125
WDR76 MAP1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
MECP2 NOC2L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 PRKDC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 RPA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
ATM CHEK1 â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 20068082
HIST2H3C TP53BP1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
CALM1 DAPK2 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
MRPL49 MRPS27 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
MRPL49 MRPS31 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
MRPL49 MRPS34 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
ATM UHRF1 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
MRPL10 MRPS31 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL10 MRPS34 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL10 MRPS27 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL16 MRPS31 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL16 MRPS27 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL16 MRPS34 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL28 MRPS31 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL28 MRPS27 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL28 MRPS34 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL4 MRPS27 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL4 MRPS31 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRPL4 MRPS34 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
LNX1 UBC â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
DYNC1H1 UBR4 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
HIST2H2AA3 HIST2H2AC â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
HIST2H3C UBC â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
PPP2CA PPP2R1A â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
HIST2H2AA3 UBC â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
DSN1 BRCA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
KIF23 ECT2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19468300 31586073 22750944
SEC13 TFG â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
MRPL1 MRPL28 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
AIP HSP90AA1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
HERC2 RPA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NCL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CUL3 KLHL13 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
RAD52 TP53BP1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
HDAC3 XPO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11779848 17141982 26673895
DSN1 NSL1 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
BARD1 BRCA2 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
NUSAP1 RANBP2 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
HIST2H2AA3 HIST2H3C â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST2H2AC HIST2H3C â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
MTA1 TP53 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
TP53BP1 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
BARD1 TP53 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
MAPRE1 KIF2C â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 7256098 19543227
UBC MDM2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18566590 19166840 17290220 19098711
MDM4 UBC â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CALM1 CAMKK1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TP53 XPO1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
MAPRE1 PPP1R13L â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
ATM PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10464290 10608806
AURKA LATS2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21822051 28205554 15147269 28628118
CUL3 PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26949739 21145461
RACGAP1 KIF23 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 8397056 22580824
PRC1 KIF4A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15297875 31586073 23870126
HIST2H2AA3 TP53BP1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD7 UBC â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
ZWINT NUF2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 20360068 26496610 26186194 28514442
ZWINT NSL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 20360068 24981860 26496610 26186194 21199919 28514442 20231385
AURKC BIRC5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21988832 27332895
CDC20 CCNB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23239745 20383333 25161877 31230944 20080579 25306923 10799291 20733055 25482201 23091007 32152539 19820702 25825779 22014574 12956947 24151075 23007861 17360335 22193957 19826003 26912231 14701726 23791783 27522463 25246557 31455778 18471975 23288039 23979597 11562349 26387737 33082289 11804586 25505175
GTF3C1 GTF3C3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
TSR1 LTV1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26344197
NSL1 NUF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
SKA3 SKA1 â—¼   COLOCALIZATION ✅ 0.87 0.87 mint 7275418 19360002
DSN1 NUF2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDC20 PPP2CA â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BUB1B ZWINT â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AURKA TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MIS18A MIS18BP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NPM1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CDC20 UBC â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
TP53 VRK1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
AURKA TACC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15064709 14602875 14603251
AURKB AURKC â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15316025 31586073 27332895
NSL1 CASC5 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24981860 26496610 23334297 26186194 21199919 28514442 20231385
PRKDC CIB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15190070 9372844
RACGAP1 ECT2 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 18201571 6166552
HDAC5 HDAC3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11931768 11804585 21081666 11466315 10869435 10220385
SIN3A HDAC9 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12590135 11959865
WDR76 HELLS â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 33288900 31353912 25817432 28514442
STK3 MAP1B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23455922 32707033 24366813
SKA3 SKA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 32296183 19360002 26496610 33106477 28514442
NCAPD2 SMC2 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
HDAC3 YY1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
RACGAP1 SHCBP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MECP2 SIN3A â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CDCA5 SMC1A â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
NCAPD3 SMC4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PRKDC TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
NCAPG SMC2 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
CASC5 DSN1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NCL NPM1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
MRPL1 MRPL10 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
GTF3C1 GTF3C3 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
NUF2 ZWINT â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MRPL1 MRPL49 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
KCMF1 UBR4 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MAPRE1 MAPRE2 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
ZWINT CASC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 20360068 15824131 24981860 26496610 26186194 21199919 28514442 17981135
AJUBA LATS2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 20303269 16413547
ATM SMC1A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11877377 11877376
BUB1B BRCA2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28985013 32286328 10749118
DSN1 CASC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 24981860 26496610 23334297 26186194 27705803 28514442 15502821
CBL UBC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CDC20 CCNA2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26496610 23007648 26960431 19098431 25669885 20733051 25750436 32152539 25306918 19483727 28514442 19826003 10679238 27522463 26811472 31455778 32307883 18471975 26186194
CDKN2A NPM1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
NSL1 ZWINT â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CASC5 ZWINT â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
DSN1 ZWINT â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
KIF2C MAPRE1 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
NCAPG SMC4 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
NCAPD2 SMC4 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
CUL3 DCUN1D1 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
DES VIM â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
AURKB ZWINT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21775627
RACK1 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350068 16189514
RPA1 BARD1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
AURKB KNL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20471944
AURKB H1-4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21511733
RPA1 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
AURKA MAPRE3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19696028
AURKB SKA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22371557
AURKB HDAC9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22865920
AURKB HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22865920
AURKB NINL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20864540
HSP90AA1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14614132 15894266 15218035
CHEK1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18317453 24627786
CDC20 BUB1B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 25502805 11702782 21407176 23643811 23239745 29973720 23007648 22566641 27939943 12196507 18591651 19098431 24464857 25383541 26960431 23443559 25669885 22000412 26986935 29432156 20512932 20733051 21926987 25012665 25833949 27694884 11907259 18997788 25482201 25750436 24581499 23091007 27114510 19820702 25306918 21300909 32707033 32152539 11535616 20360068 22100920 33310066 17598981 25852190 25673878 28404789 24151075 23345399 17360335 22193957 28514442 21335556 26912231 23791783 26811472 25246557 11274370 21937719 11030144 19407811 25241761 28096334 20212161 25505175 30341343
CBL PPP2CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
CBL PPP2R1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11053437 12593796 12815057
KRAS CCT7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
TIMELESS CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15798197 23418588
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
MDM4 MDM2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26720344 33961781 27621617 26359458 10827196 10629057 24755078 23671280 22902369 22745160 22333590 15604276 20484049 18566590 12370303 30598450 31796886 10218570 19432880 34551723 12483531 29524278 17159902 27777309 12860999 27215386 11606419 18219319 17301054 19683495 25512388 20724842 28628118 16227609 22493164 20473904 25384516 26001071 25825738 22266850 29057323 25809483 25703327 32427989 20705607 10608892 31024344 19619542 21988832 29262653 25659040 29523541 28514442 27617579 29295817 33985974 12393902 16055726 23028042 24813712 22120712 32300648 32075226 21925390 17616658 28205554 23946421 19838211 25105592 12874296 25961923
PPP2CA MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983168
PRKDC MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17570479 22444248 10721693
SIN3A MECP2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9620804 14593184 23770565 22615490 9620779 10773092 15322089 11441023
PPP2CA STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21199877 23431053
PRC1 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23444367 16431929 23716662
RPA1 RAD50 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
TP53 VRK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17689819 16782868 18612383
MRPL28 MRPL49 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
MRPL10 MRPL28 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
KIF23 RACGAP1 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
MRPL10 MRPL49 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
SMC1A SMC2 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDKN2A MDM2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ECT2 RACGAP1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
HDAC3 HDAC4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
PSMC3 UBC â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
HDAC3 HDAC5 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ASH2L UBC â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
RPA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
DES VIM â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
LATS2 STK3 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
MDM4 MDM2 â—¼   COLOCALIZATION ✅ 0.93 0.93 mint 17159902 5219425
MDFI YY1 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
AURKB BIRC5 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
MRPS27 MRPS34 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
ANLN RHOA â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
RASSF1 STK3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
UBC UBR5 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
MBD3 MTA1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
MRPL10 MRPL4 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
MRPL28 MRPL4 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
MRPL1 MRPL16 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
SMC2 SMC4 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
NCAPD3 SMC2 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
MRPL10 MRPL16 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
NCAPD2 NCAPG â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
BUB1B CASC5 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
MRPS31 MRPS34 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
MRPL16 MRPL28 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
CALM1 MYLK â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
TP53 MDM4 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 7290688 19521340
TP53 MDM4 â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 7290688 19521340
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
CHEK1 TP53BP1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
DCTN2 DYNC1H1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
SEC13 SEC16A â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
MDM2 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
CCNB1 CDC20 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
MRPL1 MRPL4 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
MRPL16 MRPL49 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CASC5 NSL1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
NCAPD2 NCAPG â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
PPP1R13L TP53 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SKA1 SKA3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
OTUD7B UBC â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
MRPS27 MRPS31 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
DSN1 NSL1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
CCNA2 CDC20 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
MRPL4 MRPL49 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
UBC USP14 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
HSP90AA1 PTGES3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RANBP2 UBE2I â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RAD52 RPA1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TP53 TP53BP1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
NCAPD2 SMC4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
NCAPD2 NCAPH â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MAPRE1 MAPRE3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NCAPD2 SMC2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NCAPH SMC4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT7 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NCAPG SMC2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NCAPG SMC4 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NCAPG NCAPH â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NCAPH SMC2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
KIF23 RACGAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MRPL16 MRPL4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
TOPBP1 TP53BP1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
LTV1 TSR1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC3 USP14 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD7 USP14 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMC2 SMC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC3 PSMD7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
UBC UCHL3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 MDM4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM4 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BUB1B CDC20 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
AURKA MBD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12354758
ATM H3-4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
H3-4 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
AURKB HASPIN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21658950 18669648
TP53 UHRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23677994 19501055 18220474 21382456
RAD50 BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA2 BARD1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BARD1 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA2 BARD1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BARD1 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
TP53BP1 BARD1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
KNL1 BUB1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21199919 20220147 17981135 25852190 22000412
KNL1 MIS18A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17199038 17339379 16622420 19410539 15369671
MIS18BP1 KNL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17199038 17339379 16622420 19410539 15369671
ATM RAD50 â—¼   PHYSICAL_INTERACTION 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATM RAD50 â—¼   SHARES_COMPLEX 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM CHEK1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM RAD50 â—¼   REGULATES ✅ 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
PPP2CA ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15510216
AURKB ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22099307 27493659
PER1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16678109 17644383
ATM RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17525332 11359916
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 29774099 20976184 26683224 25663895 12676583 17303408 14657349 29167438 27545311 10859164 19056039 15485915 28808226 12588868 16163361 15650047 12676962 17570479 14988723 14681223 26516160 10608806 26069190 29741650 12676925 23847781 17118344 11252893 20376879 15964794 15149599 18691976 19059218 20068082 15707391 12607003 25450480 17525332 11553781 19646247 15870257 15459660 20798862 19716789 11877377 12660173 11390642 15674326 16782033 28396830 28228262 12446774 15533933 15212693 29555944
ATM TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11756551 18077418 19279141 17525332 17446169
ATM MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 20651945 16943424 29065514 16511560 20860841 28690977 17512070 23002429 16163388 16082221 28096294 15788536
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM SMC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17303408 14657349 19690332 29988990 26673124 15302935 16163361 20068231 18452278 18077418 17570479 18669648 23847781 15964794 16906133 12607003 9789013 17525332 15459660 11877376 11877377
ATM PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17189255 12231622 17303408 24492479 10464290 22230547 15677476 16822724 28985363 29088817 16163361 32868446 19549901 25818648 22923485 19103741 17570479 27939942 19808981 23847781 22355272 24714417 15964794 21376743 31983282 25224041 16908529 12607003 19244120 17525332 15459660 34249431 28107384 12186630 25714019 11877377 26553138 27568553 19535303 15507430 26578593
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31175105 22438769 19962312 27322327 10608806 22389451
ATM RAD50 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17570479 17081983 15302935
PRKACA AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23861900 16222244 16246726 33744274 29764989 26165940 11039908 17545617 27242098 26481147 28869606 26134678 33988677 26831064 33760847 16083426 17895985
AURKA TACC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15630414 17145710 14602875 14603251 15064709
AURKA LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21118956 21788394 25482410 15147269 10673337 21822051
AURKA RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22438769 17563743 19276349
AURKA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 24173284 22864622 25217103 24089029 16713569 19413330 25848977 17999753 23565200 25333414 23201157 16552184 10884347 1956339 26186194 29455673 15469940 15749021 18974145 21502403 17287340 28043820 22396649 92065884 12198151 27933271 22852086 12064478 30266789 25398437 17259342 22350019 25634113 14702041
BIRC5 AURKB â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
BIRC5 AURKB â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
AURKB CDC20 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
CHEK1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23321637 22024163 17276342
AURKB VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 14762106 14722118 11895474 17081983 19007248 11420699 15676024 12458200 18669648
AURKB YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23226345
AURKB GFAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9099667 7822264 11940606 12177195 2155236 8647894 2114109 12686604
AURKB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 20959462 27933271 20847049 15469940 32873634 22611192 27496712
AURKB DIAPH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21397845
AURKB TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28415769
AURKB CKAP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20458174
AURKB NSUN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 25233213 22395603 17215513
AURKB KIF2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15630414 26148251 14972678 14960279 17567953 19632184 15064354
AURKB MAPRE3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23712260 19696028
AURKB DSN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 20471944 25601404 27881301 25660545 18640974
AURKB DES â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15630414 10574968 12686604
AURKB CHMP4C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 30905608 27126587 22724069 28004745 22422861
AURKB BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 23955284 21554500 16291752 18477699 12419797 27332895 19357306 14610074 20807437 17457057 29371939 17099693 11516652 24571573 17681274 21051298 19995937 16769825 20430883
AURKB KIF23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15630414 30728176 16461284 25512391 19203582 15854913 20451386
AURKB PLEKHG6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25336641 24482237
AURKB RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15630414 14744859 19007248 17178910 19555392 18201571 17287340 12689593 15108802 18669648
AURKB RASSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19887622 19276349
AURKB KIF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28992084 31881080 23940115 25512391
AURKB HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22865920
AURKC TACC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21531210
BIRC5 CDC20 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
TP53 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19363521 19470765 19067706 17124180 11714700 16432013 18698017 21443519 12235242 20236666 22266808 16595680 15361831 23838170 17916908 15087401 15377848 19018856 19439469 22503977 17699779 11965534 15657147 18022393 18027854
TP53 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19211844 11965534 11714700
BRCA2 RAD52 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA2 RAD52 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
TP53 BRCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9619832 11295099 18765668 12591928
BUB1B CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 63.0 1.0 Omnipath 11535616 23443559 11030144 25383541 19098431 23239745 18997788 22000412 15525512 25750436 12196507 16647857 23791783 25482201 25505175 25502805 22100920 25246557 20512932 11907259 25852190 21937719 11702782 20733051 25669885 25306918 19820702 22566641 26811472 25241761 25833949 25012665 27114510 24464857 21407176 17598981 23643811 19407811 23091007 17360335 11274370 18591651 24581499 20360068 26986935 31515488 25673878 21926987 24151075
KRAS CALM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 27410739 12727204 28666118 16043511
CALM1 MYLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 156362 1519061 6893940 23456740 7947686 6934518
PRKACA CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11574071 11574070 10187789
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
CDC20 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15577895 10679238 18471975 15840442 25669885
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
TP53 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12874009 14627709 10051609 11313928 17942917 11892838 15710382 20395210 19470724 12379461 11071927 11522645 15737644 11162602
CDC20 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDC14B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10644693 16713569
RASSF1 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 14743218 19276349
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
NPM1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16957780 20208519 15289458 16199867 16915296
PSMC3 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18805416 17334400 14665636 16713569
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CDKN2A MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 12167711 18541670 23416275 9529249 17426254 12630860 17116689 12085228 15856024 10822382 19166854 12209154 12740913 17158541 16915296 17909018 25809483 9653180 14612427 22120712 16173922 10871849 18418067 24769896 9724636 21133853 10801444 19049976 9529248 16107876 18813780 20713054 18467333 15355988 18583933 20395212 11223036
TOPBP1 CHEK1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
CHEK1 RPA1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TOPBP1 CHEK1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
TOPBP1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
CHEK1 RPA1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
PPP2CA CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11390642 17015476
CHEK1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 16163388 16511572 18356162 17110929
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
ECT2 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9789025 32203420 9113980 9641915 15774750 11149925
PRKACA GFAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9099667 7822264 19170683 11918673 12177195 2155236 31682229 2114109 12686604
HDAC3 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11486036 9346952 17925399 16189514 18940814
PRKACA HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22865920 20716686
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
PTGES3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 16565516 10642522 11447118 26804907 15916966 11413142 16403413 21988832 11812147 19875381 19740745 14761955 12077419 10811660 20039095 22806877 25036637 20048054 19996313 18285346 20661446 22315411 23022381 18172314 20159553 22729780 22504172 16289154 9817749 14987994 8114727
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
KIF4A PRC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23870126 15297875 15625105
KRAS PEBP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17097642 10490027 25597358 10757792 19158341 18294816
TP53 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11514734 18555006 10953306 14741382 19107228 20124454 8274455 16061648 10448271
STK3 LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26898830 21832154 15688006 23431053 21808241
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
UBE2I MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
NCL MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24147044 16751805 22103682 20195357
MDM2 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 17145710 10218570 17616658 16511560 22266850 12874296 21925390 25825738 21988832 25512388 16227609 22493164 22902369 25659040 18219319 12963717 15604276 18566590 12370303 19838211 26359458 27617579 25809483 34551723 10608892 23028042 22120712 25703327 12860999 32300648 16055726 24813712 17301054 12483531 23671280 17159902 27621617 25105592 20484049 20724842 27215386 10827196 26001071 11606419 23946421 19683495 20705607 24755078 25384516 20473904 12393902
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
TP53 MDM4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16492744 18172009 21750655 20036872 21422812 17510313 9926934 18336191 19521340 20372076 10469568 20080970 22290440 21394211 23474762
MDM4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 25609649 18677113 28487147 24445145 30045945 20515689 26148237 22266850 11528400 19521340 21088494 16713569 15916963 9226370 12874296 21925390 16024788 25825738 24667498 16227609 24127580 8895579 20174603 18485870 12963717 15604276 25464845 12370303 10608892 23028042 25961923 26186194 17110929 22374672 26876197 17301054 23671280 21965653 17875722 22807444 10075736 19305137 17080083 29023092 27114532 20724842 10827196 19255450 24659749 28035068 23946421 20705607 19075013 21075307 12393902 11223036
TP53 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21611785 11713584 10365096 15217513 16258956 14675138
NPM1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 23443559 15144954 16740634 15310764 16376884 12080348
NRAS PEBP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17097642 10490027 25597358 10757792 19158341 18294816
PPP1R13L TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17906639 21192816 18275817 16713569 15558054 12524540 23623661
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18201571
PPP2CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17245430 14712210 1848668 16713569 12556559
PRKACA VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 14762106 20058876 11895474 19007248 23737341 19691289 28117759 18669648 18767875 2500966 20068231 19144319 17287340 12761892 22345628 19664995 18212344
PRKACA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12654918 21572420 20591975 8599934 16109481 34088899 11162591 15890975
PRKDC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 15355354 19398950 15254178 9372954 11483158 7862459 16713569 11875057 11551930 11883897 12548019 25168287 8502477 11709713 10446957 28145533 22726545 24886358 16552184 12242661 17570479 10196661 10747897 9885574 10673501 12091386 22355272 9765199 15489221 9561848 10801407 22504299 22444248 15177184 11042698 10358069 10470151 10606744 9744860 16397295 12959929 12064478 27130668 10951572 12111733 25937999 15381073 28102346 9363941 19918261
TP53 RASSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23779024 23038753 21364923
RASSF1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17379520 24366813 26186194 14729613 22195963 24255178 20920251 21808241 21199877 19962312 20086174 32296183 17598981 29063833 18347058 17889669 23455922
RPA1 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
SEC16A TFG â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17005010 23479643 12235121 19638414 25619252 21478858 22675024 17192411 22157747 25586378
YY1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10787423 10634504 8816507 10505791 18391986
VRK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18612383 12782311 29340707 11551930 11883897 29679095 11709713 18286197 24126608 26412148 15542844 28927264 10747897 10673501 24731990 26706601 10606744 10951572 24492002
TP53BP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25579814 12110597 25837623 16713569 14978302 22653443 26022179 27546791 8016121 12351827 15611139 15364958 14985081 19433796 17805299 25651062 11877378 17634560 22084066 20307547
PRKDC CCNB2 â—¼   KO_UP_REGULATES ✅ + 1.01 1.01 PKG 28854368
PRKDC ATM â—¼   KO_DOWN_REGULATES ✅ - -1.5 1.49 PKG 28854368
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
ATM VIM â—¼   KO_DOWN_REGULATES ✅ - -2.44 2.43 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368