Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
IRF3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21952047 23532979
OTULIN UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBB OTULIN â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 7851534
UBC OTULIN â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 7851534
TRAF3 MAP3K14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
XPO1 AGO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
CHEK2 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32187724
STYK1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31696776
TRAF6 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20501938
CASP8 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TNFRSF1A CASP8 â—¼   COLOCALIZATION 2.0 0.8 intact 8095238 21157428
MAVS CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16406812 21419663
TRAF3 CD40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7527023 5220338
XPO1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19940019 18573912
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CTNNB1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24291232 24482235
UBB DAZAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
DAZAP2 RPS27A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
EPAS1 KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
FOXM1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346 17875680
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
FOXM1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
KDM1A FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
HIF1A KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
HIF1A HIF1AN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24421387 19726677
PIK3R3 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611271104 17360667
IRAK1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218906 16884718
TRAF6 IRAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10383454 5211610
TGFBR2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16360132
RAF1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
MAVS UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
MAVS TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAVS UBC â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
MYC TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBC NEDD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
OTUD7B UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PAK1 RAF1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17097642 5219317
TAX1BP1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
RPS27A TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YAP1 SLC9A3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217948 16166090
SRPK1 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
TRAF3 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF6 TAX1BP1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 17703191 5226445
UBB TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBA52 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC TNIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
TNIP2 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
UBC YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAB WEE1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 10775038 5212493
MAP3K7 MAP2K6 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 21902831
OTUD7B UBB â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
TRAF6 GSK3B â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 30711629 30806153 31594754 31754475
NEDD4 AKT1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 19953087 23195959 31390487
UBC SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5216530 12857745
CASP8 TRAF6 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
ESR1 YWHAB â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
MYC RPS27A â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
YAP1 GSK3B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 24976009 29789528
ESR1 ACAD9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
CDC20 AURKA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 10377410 22340593
ESR1 AURKA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 21761334
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
PAK1 ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12374744 16452229
SOX2 KDM1A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30442713 28794006
MYC SYK â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
SOX2 PAK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STK4 XPO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23386615 26673895
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
RPS27A UBE2S â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
SRPK1 CDK7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23602568 32707033
ESR1 KDM1A â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 17289570 23403292 31527615
ESR1 SRPK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33731348 31527615 21182205
YWHAB IGF1R â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 9581554 6547842
MYC XPO1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29467282 17314511 26673895 32140074
BECN1 TRAF6 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MAP3K7 RIPK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
AKT1 AURKA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24412244 28205554 28628118
CCNB1 CDK7 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 28514442 26186194 11113184
MYC HIF1A â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15071503 28205554 28628118
IRAK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
YWHAB YAP1 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 8008024 17974916 1602907
FZR1 UBE2S â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
UBA52 UBE2S â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
MAPK1 RAF1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
BECN1 XPO1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 26673895 11309306 16713569
TRAF6 CASP8 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16436380 27810922 16920630 30979779
CDC20 FZR1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
BECN1 NEDD4 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21936852 29251248 28128446
SQSTM1 PRKCI â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 20808283 8075909
TRAF6 ULK1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33201521 23524951
IGF1R PIK3R3 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
YAP1 YWHAB â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
NEDD4 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMB1 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMB1 UBC â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CDC20 CCNB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23239745 20383333 25161877 31230944 20080579 25306923 10799291 20733055 25482201 23091007 32152539 19820702 25825779 22014574 12956947 24151075 23007861 17360335 22193957 19826003 26912231 14701726 23791783 27522463 25246557 31455778 18471975 23288039 23979597 11562349 26387737 33082289 11804586 25505175
MYC CDK6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 22094256 28205554 28628118
NEDD4 EGFR â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 19953087 33762435 29455656
EGFR RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
MYC KDM1A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 30415952 23455924 32296183 29467282
MYC UBC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21150319 16996503 19131971
NEDD4 UBA52 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MAP3K14 TRAF3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMB1 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TANK TRAF3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
FYN CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 12640114
MAP3K7 TNFRSF1A â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
TAX1BP1 UBC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
IRF3 MAVS â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDC20 UBC â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR TNK2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
OTUD7B RPS27A â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
BECN1 AKT1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28205554 28628118 29669822 23112296
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CDK5 CCNB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 23455922 25852190 26186194 28514442 23602568 32707033
CDC20 UBE2S â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CDK4 CDK6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 23455922 28205554 28628118
CDK7 ESR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10949034 31527615 15461668
YAP1 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22234184 8383887
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
NEDD4 IGF1R â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18632619 12697834 18286479 19165858
IRAK3 IRAK1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10383454 19166926 12138165 21903422
RIPK1 TRAF3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32296183 8612133
BECN1 ULK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CTNNB1 YAP1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
MYC GSK3B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16247449 20713710 19131971 21150319 31638140 29467282 11877389 33541412 14563837 8247524
EGFR AKT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
MYC CDK4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22094256 28205554 21988832 28628118
RAF1 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7517401 16189514 16713569
HIF1A UBC â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
FYN GSK3B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
MYC GSK3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
CTNNB1 IRF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20453844 9541017 16154084
MYC IRF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
TNK2 AKT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 10652228 11394904 18470881
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
ESR1 AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21761347 21761334 18497064
CASP8 TNFRSF10A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CCNB1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 1836978 1384126 8428596
CDK4 DAZAP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23607968 22234184 23245941
PRKACB CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22094462 21506126 21303971
UBA52 DAZAP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SQSTM1 DAZAP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HIF1AN EPAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12573436 12080085
SQSTM1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12034707 10747026
MAPK1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
TRAF6 MAVS â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31390091 21903422 32511263 20080758 30527812 26221961 31806368 23545497 22908223 29125880 26385923 16153868 27348524
MAVS TANK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19668221 19479062 17327220
MYC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28205554 17314511 28628118 9315742
MYC UBA52 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC PIK3C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PSMB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SLC9A3R2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PAK1 RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11733498 12551923 17097642 9823899 9234708 10205168
RAF1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
TNFRSF10A RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9430227
TRAF6 IRAK1 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18347055
PRKCI SQSTM1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMB1 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CASP8 RIPK1 â—¼   CLEAVAGE ✅ - 0.9 0.9 Signor 10521396
TRAF6 MAP3K7 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18758450
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
MAP2K6 MAP3K7 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CD40 TRAF6 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
SQSTM1 TRAF6 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
CASP8 RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HIF1AN HIF1A â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 6802010 19071119
RPS27A TRAF6 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MAVS TRAF3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
SQSTM1 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
UBB UBE2S â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
AKT1 STK4 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 19940129 17932490
IRAK3 TRAF6 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 10383454 32296183
TRAF3 MAVS â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 22792062 26221961 23545497 22908223 19893624 20080758 30527812 24622840 29125880 22022264 22079989 31390091 33411856 16858409 30267576 22901541 21200404 32324863 33608556 19419966 32511263 31806368 26519536 27980081 32366851 33582548 27348524
YWHAB RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 19595761 8009093
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
IRAK1 TRAF6 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
TRIB3 AKT1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 31844113 12791994 30071535
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
CCNB1 FZR1 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
CCNB1 CDC20 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
TNIP2 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
OTUD7B UBC â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
UBC UBE2S â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
OTULIN UBC â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MAVS TRAF6 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
NEDD4 RPS27A â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NEDD4 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CD40 TRAF3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
HIF1A HIF1AN â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MAP3K7 TRAF6 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
GSK3B MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 18463697 21646472 30037819 26751215 25647305 2663470 20080742 19797085 30003124 16855632 12040186 18679417 11018017 23331499 29229669 16611981 21071413 24265759 20068231 10671551 16039586 17570479 16023596 29258530 12615961 18669648 21113395 22461507 19131971 8247524 16247449 20604938 19575820 15150404 22481935 23668310 19651622 17444818 23964270 20537194 22893788 27684546 24662831 25333250 20399964 11877389 14563837 18408012 17052453 18455992 15212693 16371461 11274345
GSK3B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
GSK3B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
TRAF3 IRF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
MAVS IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17020950 25636800 21903422 16153868 22750291
OTULIN UBC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23708998 23827681 24726327 25527291 23746843 26235645
CD40 MAP3K14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19426221 12374738 24298274 9718306
TRAF6 MAP3K14 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
CASP8 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11002417 10753878
RIPK1 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11116146 15047705
MAP3K7 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 10094049
TRAF6 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9275204 11278268 25241761 16286467 10921914 16189514 10075662
TRAF3 MAP3K14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 17145710 18997794 9275204 15208311 11278268 23543740 18997792 14743216 15084608 32296183 25246529 20348096
MLST8 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17517883 17277771 18372248 12524439 17386266
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
TRIB3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 30071535 12791994
MLST8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19203586 15718470 19568798 15169778 19720745 17517883 18925875 10949026 11715018 19143635 17277771 18636226 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
TNK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22322295 11394904 25678401 20333297 10652228
AKT1 UBE2S â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29562639 27593939
AKT1 CLK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20682768
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
AKT1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 27979972 25360797 26804165 28273460 25751140 24101154 25751139 34052254 25362852 28114269 28793266 26265440 31239271 25601544 28474680 33630828 26119935 27144834 27425596 25531778 34206989 34465890 21945154 25195862 31792377 18640976 28775168 32015438 32523092 22234184 33536280 33622361 30600590 24362629 34155345 24658687 21060948 33162394 20153295 26668327 21730131 26549256 21666719 25605730 26039999 34226698 20823509 34516278 27033705 32064037 32271880 32513743 33990468 24812269 32053631 32929029 34058200 25772246 26364602 27765911 26678338 27979971 33552953 28171658 34129887 21376238 28416665 25998128 25109332 12535517 31988076 26933062 26598551 25373897
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22619175 19369195 19737514 19940129 17932490 23431053 11805089 24872389 23893242 17726016
AKT1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11435472 14749719 24886428 14585966 23397142 9032240 12138087
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
HIF1A AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18562694 19828020
MYC AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20890087 20519624 14744757 20682043
PAK1 AURKA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24867643 16246726 22864622 21589936
AURKB CDC20 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
FOXM1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15817462 15689977 17173139 16314512
BECN1 PIK3C3 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
BECN1 PIK3C3 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 17106237 17446862 18612260 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 27754749 28645028
ULK1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 26390974 25545884 28301741 29734735 29233870 30292171 28518135 29313410 24191236 26546165 24848530 25026281 26921696 25026296 25373623 17595159 16940348 26108642 29371398 25891078 23685627 24370004 26008601 28238651 30397185 29233871 24834848 29867359
BECN1 PIK3C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 18628207 36042481 19713971 19050071 16179260 25594178 21936852 18843052 24980959 28128446 25906440 26496610 26783301 23954414 19379691 23332761 20562859 23974797 24034250 16390869 24980960 19270696 25825496 19172397 20711182 23315026 25490155 24472739 17438366 23364696
IRAK1 BTK â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 21606490 11544529 17890055 19679662 20485341 17878161 16024789 19224918 20400509
BTK TRAF6 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 18070982 15247281 21220427 12140561 12138165 8837778 19592497 18347055
SYK BTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 18083107 8629002 28368423 11598012 28359287 29455639 19369195 10051622 9012831 8630736 28088788 11226282
MYC CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15367674 12695333
MAPK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 24342355 17290218
TNFRSF10A CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19427028 12218097 10894161 17047155 21785459 17898872 22421964
TNFRSF1A CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15357952 12887920 21741934 8875942 15725726
CASP8 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 11002422 34389694 19524512 8657102 17047155 10469655 21458669 21419663 21525013 12842894 18570872 21741934 10521396 11002417 12884866 20203691 22421964 11042193 20125124 12887920 12215447 19935698
EGFR CCDC50 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19059208 15951569
FOXM1 CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11572993 19276163 15671063 11682060 19097132 23812424
MYC CCNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 11522645 11983916 19470724
FOXM1 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15817462 15689977 10567581 11572993 11682060 15024056 11391529
CDC20 CCNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CCNB1 WEE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 8348613 9001210 19652693 18590585 7575488 12814430 17303408 10373560 7681363 9268380 12124778 15279786 8515817 15037762 17660363 16123593 15070733 15917306
CD40 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 20614026 17145710 21041727 9133417 7859281 12637493 10352240 16260598 15485859 24810049 17878343 9384571 7530216 12220533 18635759 14517219 9990007 24260396 10428814 17332487 19667091 7533327 9168896 10984535 27716849 9718306 10318845 11562359 7527023
CDK4 CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
MYC CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15208653 12835716 24951594 21384303 14519204 22395148 10688915 17728244 11983916 18414489
CDK7 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7533895 14597415 19847258 8139570 12814430 17386261 16327805 16782892 28368408 17884153 19667075 15703371 14754892 12648680 11900249 12459251 16697054 19809470
MYC CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21988832 11602341 17093053 22094256
CDK4 FOXM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26279295 23240008 22094256
FYN CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 24872417 19901323 9038181 10896159 18691976 20506281 29063113 20068231 16497976 19413330 14757045 12372285
CDK5 PIK3C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 26108642 20513426 27680387 28858266 27406233
CDK5 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20058876 17114649 12176333 12950086 19298660 19664994 12176334 15542607 19413330 23537649 19036346 19664995 21825040 11604394
CDK7 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
MYC CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20682794 22395148 12835716
CDK6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17208333
CDK7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 30257348 10949034 15461668 9528769 22879364 12118371 28423697 27748765 15059947 16076840 7491495 12093745 23850489 15528270 7838153
CHEK2 FOXM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17101782
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
FYN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 20026641 22264731 24511551 25241761 22340496 12640114 25803041 26509276
PAK1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 28007610 28423670 23543898 25639486 26547035 22369945 23162742 25472536 21822311 25225063 27713506 27910850
EGFR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19104148 27401557 15371335 16099633 22558232 30747223 12040186 26509276 24816560 12740122 25500543 17318191 19568798 21423209 14585353 34227224 23640056 17496910 17052462 24240237 25164010 14517306 21903109 22200182 16952352 20858269 28035485 9233779
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
RIPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11116146
EGFR PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17496910 31980649 25241761 16273093 24658140 25402006
EGFR TNK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 20359967 8647288 20432460 17182860 15951569 8497321
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
EPAS1 HIF1AN â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 6.0 1.0 Reactome 12615973 11823643 14701857 12042299 12080085 15239670
KDM1A ESR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17277772 24371278 19098913 18187655
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
PAK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18521086 26944939 16778166 18755239 21893191 15178330 19205871 29548483 26554417 27003261 24505617 16452229 15193262 19557173 15642175 12374744 19465939 17604944 25447917 20179234
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
MYC FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20658516 18798339 12695333 17341548
HIF1A FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22831955 19097132
FOXM1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17141659 10567581 17655499 16965535 11391529
SYK FYN â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10358164 11907067 12524384 14568985 15536084 17101731 19909365 20150200015 21149606 21378271 21910624 23609447 8189062 8226994 9000133 9295024 9314552 9396765 9632805 9763615
FYN SYK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7797565 7513017 17570479 10477689 9535867 16713569
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
HIF1AN HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11641274 12042299 12080085 12215170 22841746
HIF1A PIK3C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15806152 16682453 15833446 16618748
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
HIF1A HIF1AN â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 6.0 1.0 Reactome 12615973 11823643 14701857 12042299 12080085 15239670
HIF1AN HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 12573436 11641274 14734545 12042299 12215170 12446723 17244529 19071119 17003112 12080085 19696166 16189514 19940151 24145445 26751287 12432100 26972000 17382325 19074848 26752685
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
NEDD4 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 18988627 12697834 19165858
IGF1R YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12767520 10826997 12444011 21540285 15629149 17353931 19030972 14651979 17145710 16931767 9581554 12175651
IGF1R PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17496910 25241761 9415396 9524259
TRAF6 IRAK1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
TRAF6 IRAK1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
TRAF6 IRAK1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11274345 12150927 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
IRAK1 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
IRAK1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 10346818 17145710 17785851 16024789 14625308 11259596 10383454 18234474 9374458 11287640 23244239 21220427 11518704 19166926 16951367 15894263 10747026 35926385 18056395 12566447 12496252 22447928 12242293 8837778 10920205 11960013 19716405 24735611 20043910 24434549 17785432 11397809 18347055 22033459 12140561 23381138 17197697
IRAK1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12242293 17197697
IRAK1 IRAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19166926 17145710 10383454 21903422 12138165
IRAK3 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21098228 17145710 10383454 32296183
IRAK3 TRAF6 â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 12150927 12620219 14660645 18264787
TNFRSF1A MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TGFBR2 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530
RIPK1 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
TRAF6 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849
MAP3K7 MAP2K6 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
PAK1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7592586 11304531 15677464 11309380 14970210
MAP3K7 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 16200688 17301840 18855897 15125833 24699077 17363905 18641653 21902831 24403530 23331499 20060931 21133840 21614932 21232017 12738796 23606331 18264787 10391247 21220427 18988627 16799562 12620219 14633987 19161412 22941947 11280761 15082531 26192618 14660645 24958845 20164171 11460167 16603398 21041997 15282297 11274345
TRAF6 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21614932 12738796 11274345 16313339 18855897
TNFRSF1A MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
RIPK1 MAP2K6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
TRAF6 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
RIPK1 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF6 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 19675569 17947236 19843958 10882101 19521662 11259596 17079228 28024152 31885808 19112497 22924441 10094049 27501752 18922473 11518704 11809792 16517750 19232515 10702308 16410796 14633987 19820695 22851693 10921914 18758450 12496252 12609980 21822258 12242293 25963657 24434549 27249171 22643835 21245467 17965022 26038599
RAF1 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17081983 18767875 15849194 19690332 11409918 14654779 23331499 23180781 8226933 20068231 18988627 21917714 18669648 19541618 18691976 16407412 19933846 9922370 15664191 8388392 19651622 10801873 8349614 18775330 9604935
MAPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19604315 15542607 16964243 15212693 11604394
MAPK1 TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10702263 11606045
MAPK1 MKNK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 10655591 15547943 20080742 12040186 15173823 12697810 11940578 16227978 23047924 9155017 10922375 12738796 16039586 17255949 15187187 19541618 19091303 19565474 17052211 10022874 32296183 18039929 18775330 10601235 12792650 11431469
MAVS TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22901541 19893624 17020950 18818105 21200404 16306936 18207245 19546225 22844514 22792062 19193783 34610835 16858409
SQSTM1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15340068 16252010 20531300 21981924 25002027 26587781 28574505
MLST8 MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MYC NUP155 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12747840 18414489
PAK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 28007610 19421139 26333361 22096607 15849194 12952546 30197477 12551923 23162742 25733387 17097642 22105362 18465753 23331499 24924700 10801448 26257058 21917714 12719581 11376654 25843685 15664191 19165420 23576562 23506953 10205168 24505617 28415790 18775988 22983922 9234708 12952943 16129686 25472536 11733498 11948406 9823899 11897507
RAF1 YWHAB â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 YWHAB â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 8085158 12620389 16093354 19595761 7882972 16041367 24255178 11697890 7935795 8702721 10848612 16189514 25852190 7644510 12360521 10620507
RIPK1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
RIPK1 TNFRSF1A â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
SQSTM1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26416459 10356400 19850933
TNFRSF1A RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 25681446 11002422 20547836 8612133 18450452 27552911 26802121 10356400 19773432 18621737 23815148 16611992 22179575 12721308 21741934 7538908 18949366 21113135 8985253 10744744 10795740 21119000 22733818 10755617 27321185 15115707 24098568 18939944 18329793 20825417 20448643 15357952 21737329 12887920 24130170 15258597 24758719 16115877 19524513 18724939 16968706 22817896 28817177 18022363 19815541 25388546 21331078 22848449
TRAF6 SQSTM1 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
TRAF6 SQSTM1 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
SQSTM1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15870274 27458013 10747026 27681126 16079148 16189514 18382763 16874300 11244088 17389358
TGFBR2 TRAF6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 11013220 11133108 12154066 12717440 12724770 12767520 12809600 14557817 15265520 15548370 16474430 17673906 17934056 18758450 18922473 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 22943793 24132110 24336330 7594497 9865696
TGFBR2 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 12717440 19050695 11133108 14557817 19920116 22710166 19114990 12767520 22703233 23331499 11013220 20060931 17934056 21614932 17673906 20644162 24132110 18922473 9865696 22943793 20519943 21900405 12154066 7594497 18758450 15548370 24336330 21278795 12724770 19010789 15265520 16474430 26192618 12809600 19109155