Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
BAX GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0912742107 20080742
PBK CDK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10779557 5212518
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
TP73 EP300 â—¼   ACETYLATION ✅ 2.0 0.8 intact 11804596 5215037
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
NFE2L2 KEAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19560419 23850759
NFE2L2 KEAP1 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 19560419 23850759
NFE2L2 KEAP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19560419 23850759
PPP1CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
MAPK11 PAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BMX TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217965 16186805
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 PRKAA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
TP53 NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12808109 22701761
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
TP53 DDR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP73 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19815500 0905867106
RELA CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
NFKB2 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
RELA RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPRE3 MAPRE1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TGFBR2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16360132
RELA CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
RELA CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18425349
PRKCZ RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12881425 5216561
NFKB1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
VHL HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
HIF1A EGLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
EGLN1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 0.8 0.8 mint 7987706 20840591
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
EGLN1 HIF1A â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 5217229 15474027
HIF1A EGLN1 â—¼   HYDROXYLATION ✅ 0.8 0.8 mint 5217229 15474027
SP1 FGFR4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11981041 15475466
SP1 NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7541912
SP1 PPP1CC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9028876 12684058
PPP1CA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8288823 20186153
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
PPP1CA AKT1 â—¼   COLOCALIZATION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288823 20186153
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
NFKB1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
PRKCZ NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11684013 12881425
PRKCZ VHL â—¼   COLOCALIZATION 2.0 0.8 intact 5219754 17350623
PRKCZ MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667433 17646398
SHANK3 CSNK1D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
MAPKAPK5 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10978313 11274345
SHANK3 PPP1R13L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
CDK1 CDK7 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 20360007 11113184 16327805
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
SOX2 PAK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
SRPK1 CDK7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32707033 23602568
CLK3 CLK2 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 8153045 21516116
EP300 VHL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
WEE1 CDK1 â—¼   PHOSPHORYLATION ✅ - 0.83 0.83 Signor 16096060
CDK1 WEE1 â—¼   PHOSPHORYLATION ✅ - 0.83 0.83 Signor 15070733
CDK1 BUB1 â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 16760428
SOX2 CDK1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23667531 30297536
EP300 RAN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12649209 33742100
NUP153 RAN â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
CFTR RAN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 31324722 29924966 17110338
VHL EGLN1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22286099 17986458 26215701
MAPRE1 PPP1R13L â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CLK2 CLK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 34133714
CLK2 CLK3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 16189514 25416956 34133714 33961781 21516116
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
AKT1 PAK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24886428 23397142 14749719 12138087
PPP1R13L PPP1CB â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 21998301 270751 8217559
CHEK2 TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RELA SP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 TP73 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PTK2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
CDK4 CDK6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23455922 28205554 28628118 33961781
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
PPP1CA PPP1CB â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CLK2 CLK3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
PPP1CB PPP1CC â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HIF1A SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 17024177 17418410 15780936
PPP1R13L PPP1CA â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 21998301 270751 8217559
PPP1CA PPP1R13L â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
NFKB2 RELA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
CDK1 NEK9 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16079175 12101123 21642957
PPP1CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
TP53 DDR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8977099 21398698
STK17A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17339337
TP73 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16413471 21436470 18026135
TP63 DDR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
TP73 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11238924 19815500 10373484
SP1 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12840223 11297539
PRKACA PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19942859
NFE2L2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17313370 18241676 18199529
CREBBP NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12789342 16835236
HIF1A EGLN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24681946 20724477 31763849 15721254 20812988 25974097 16407130 27563096 26611735 29279301 17069766 22946054 15474027 20840591 17442832 33550096 23413029 18264140 25361009 18063574 16511565 34007068 16155211 19604478 17353276
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
SP1 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14561739 16452190 9295358
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
TNK2 AKT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 10652228 11394904 18470881
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
NFKB1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24296733 18425349
CDK5 PPP1CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 010002200 11320080 8286802
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
CSNK1D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21316585 23331499 11818547
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
PPP1CA NEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17283141 10880350 12221103
STK4 STK38 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19062280 24747552
KEAP1 WDR83 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
EGLN1 HIF1A â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
AKT1 STK4 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 19940129 17932490
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
PPP1CC PPP1R7 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PPP1CB PPP1R7 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PPP1CA PPP1R7 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
HIF1A VHL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15082527 11865071 11226425 10944113 14556007 11986208 15527772 17973296 12538644 26735336 24899725 12606543 21358672 24015760 16611863 23401859 18062927 21332579 15805242 19940151 12086861 27281823 23413029 33060856 11292862 24316222 16155211 24857547 22932900 29121446 11292861 12101228 15060148 18047470 16278378 21602890 27320910 12464182 26611735 32589900 18402654 25500545 12050673 18694926 26215701 10878807 25361009 11641274 22351759 34007068 18305400 21316481 11024059 34195792 26037477 34174286 33039559 10823831 26743088 31810986 10353251 15833858 17558023 11566883 23580587 27563096 18985005 19123984 25438054 12682018 18323857 23387829 17442832 33550096 18222538 18426857 17047048 12004076 34230460 23318261 33961781 12808024 21335603 12586829 17353276 11358837 28514442 20724477 16140212 12205091 20049704 16862177 11331613 32535973 15721254 14691445 15385570 10973499 15611064 17981124 28775317 12925778 26496610 17339318 30237125 20458141 20639890 17986458 19147576 28425505 11504942 22369643 18264140 16511565 12351678 14600153 30988076 17132228
NFKB1 NFKB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14743216 27609421 21988832 17962807 15169888 35140242 25609649 15660126
PPP1R13L TP53 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAPRE1 MAPRE3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
KEAP1 NFE2L2 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
NUTF2 RAN â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG16L1 ATG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PRKCZ BAX â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10873802 10934475 10954424 14766748 15642728 17525161 20505164
NFKB1 BAX â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 12676992 15613549 21725609 23178297 23572150 7834749
TP73 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18034190 17346710 18421303 21245298 10559267 18418051 18644986 17521288 19067706 11748232
HIF1A BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18366759 17558861 15706354 24349374
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
SP1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278953 10510469 11748232
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
MAPK8 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525785 18471544 16709574
AKT1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26763134 14766748 15642728 17525161
PRKCZ BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16679323 14766748 15642728 17525161
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
GSK3B BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29379583 27762303 15525785 20976235 26287183 17911107 16709574
CDK7 CDK1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11900249 12648680 15703371 16697054 17386261 17884153 19667075 19809470 19847258 7533895
CDK1 WEE1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 23508805 23897299 7575488 9892021
TP73 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19861536 11593387 19067706
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
TP63 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11593387 19861536
GSK3B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9832503 17359287
WEE1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 135.0 1.0 Omnipath 26658951 28126323 15592455 11202906 27196765 20406171 19415658 8578591 22709126 26006103 11730318 20813250 96108162 26025928 11807090 26057002 23410205 24666614 19651622 16096060 15350223 23166842 24716182 8428596 22770610 25174607 28396830 20498628 20530684 25361894 20465818 11527575 25733813 18285803 25283841 25458954 1384126 16497976 17480229 9552418 10564259 24143279 22546375 18669648 7749193 22494620 29930204 18691976 21660227 17192257 9001210 29044141 20347419 23727417 15837193 17016520 19901323 26804466 28928160 21389100 14972559 24415942 24651440 7743995 20068231 25344910 27878946 10209262 27669826 8972180 10896159 28539822 19821025 26131711 25774168 24136233 24536047 23537585 8084605 7774574 24927813 26899266 19305423 25609063 19413330 18385244 25301733 16083285 27196784 18452278 26081366 28264028 29217775 29500418 22836368 11751453 18378775 17718912 20609246 20058876 9268380 27532275 18469858 23494566 24630986 15964826 24970150 12186947
CDK7 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 85.0 1.0 Omnipath 16565220 18767875 11113184 33657372 27303922 19690332 19667075 15703371 10913154 14988404 1532335 29793495 20360007 7799941 19158392 19664995 33574676 19809470 8548828 7533895 17386261 34489572 26881937 17554681 20068231 18452278 21900495 18669648 12814430 16327805 18691976 15868411 8441405 21778139 25849598 27908669 12459251 1833185 19651622 22263797 19847258 19707596 17924679 20347419 29435156 18220336 34370741 19369195 22505032 21468563 17884153 12663041 22425727 7944411 12648680 11900249 8344251 16697054 31429764 24970150
CDK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 17274640 22367880 18088087 17202132 9122166 97225924 10880350
CDK1 BUB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 26912231 28072388 23637705 29971233 29868582 16760428 20633640 33125045
CDK1 CEP55 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 19415658 17081983 29743530 19691289 18767875 18691976 19664994 20068231 18452278 19413330 16964243 18669648 16198290
CDK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25398907 28831131 20150555 22266860
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15985436 17620410 12676926
CDK4 CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK7 CDK6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CDK7 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7533895 14597415 19847258 8139570 12814430 17386261 16327805 16782892 28368408 17884153 19667075 15703371 14754892 12648680 11900249 12459251 16697054 19809470
CDK7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17591690 11709713 12064478 1088347 16083285 9372954 11483158 9620776 10348343 10884347 16552184 9315650 11007451 9571186 10747897 17898864 1454855 11585729
CHEK2 TP53 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10710310 10673501 10570149 10673500
TP53 CHEK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15326376 19435816 10531348 19395378 15044452
CHEK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 18778462 25545885 16893723 15254178 18833288 23892398 12052256 18319725 25372714 15459660 20514219 25174607 28140789 17339337 22420423 18566216 20950777 20651945 15810020 15700044 22891162 17157788 11551930 18725978 10724175 15467443 23351141 20096447 11063934 11709713 15659650 12242661 10656682 15140942 20041275 11728459 18614044 12781359 22649771 18812180 11173129 10570149 15279785 20081365 20860841 11875057 22778557 19923893 24553354 22797063 26384650 23316480 15489221 19788416 10801407 21187893 9843217 9733514 10710310 24358900 21526939 23843721 29805302 9733515 25404613 12548019 21625617 10673501 11447225 17118344 26610585 19544417 28038466 12810724 25823026 15024084 17464182 15862297 19933256 20526329 12111733 20183804 23144912
CHEK2 VHL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22071692 23315288
AKT1 CLK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20682768
CSNK1E TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10606744 11709713 10951572 10734067 16713569 11551930 10747897 10673501 11883897
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11804596 19407812 15175157 19788416 12660246 19218448 10648616 15454570 16998810 25675294 15893728 18663001
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
KEAP1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 104.0 1.0 Omnipath 30122040 17020408 31257023 35380342 16449638 22245129 18417180 28939422 15475350 24130096 20421418 12145307 32057361 17462537 23727018 24704364 34894983 23857982 19920073 31262713 20599909 36038548 24997453 17015834 23722832 21988832 30778200 24322982 36333711 20486933 30465941 22448038 30576774 21262351 23645672 16888629 31169361 11909699 26078718 25582950 19706542 20463144 16006525 18694732 11439354 15985429 15572695 34815381 28186440 23066931 19560419 15601839 23986495 25628777 27212020 22302998 30793592 16790436 26536456 24512214 17822677 20027226 28533375 22215675 29423025 14517290 32911434 20484052 14585973 18387606 23382044 21383067 32159343 18757741 27091842 24011591 9887101 31941496 22558124 36165926
FGFR4 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
NFE2L2 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19454702 23708697 17467702 21808062
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
PRKCZ MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11035106 12942541 23109003 12900386 15721486
MAPK1 CEP55 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 19415658 17081983 29743530 19691289 18767875 18691976 19664994 20068231 18452278 19413330 16964243 18669648 16198290
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 MAPKAPK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9628874 21666810
MAPK1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19604315 15542607 16964243 15212693 11604394
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 RPS6KA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15187187 19541618 19565474 20506250 18813292 17052211 15547943 16393692 17570479 9687510 17255949 11274345 12697810
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
AKT1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11435472 14749719 24886428 14585966 23397142 9032240 12138087
CDK5 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20058876 17114649 12176333 12950086 19298660 19664994 12176334 15542607 19413330 23537649 19036346 19664995 21825040 11604394
TP53 CDK5 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10604467 17591690 12064478 18490454 10500146
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 PTK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24809783 20515733 21355845 21071137 21269258 18493017 17999388 17725966
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
PPP1CB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16501611 15178317
PPP1R13L TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17906639 21192816 18275817 16713569 15558054 12524540 23623661
MAPK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 12356735 14665630 26158765 18778462 12969974 12861053 15254178 17135248 18669630 12384533 17363488 17698850 11283254 10706102 21454683 18931691 11551930 11397945 14612532 15064747 15963507 11175334 11423984 27147566 29234486 24657168 10581258 14517211 17353187 10673500 22030623 14527925 22728651 17525747 15629715 9393873 11447225 15671037 22285752 17245430 15140942 28673515 23871434 11078726 20041275 11896587 16731759 17121812 33514736 11861384 25431954 12810724 17967874 12955074 21832239 16818520 12756247 23798621 11526498 20009884 16713569 10202145 11850826 11896572 10710310 10570149 12959929 15269203 11583595 21148320
CSNK1D TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10606744 16870621 17101137 9349507 25241761 11709713 10930428 10951572 17570479 19345189 11551930 10747897 10734067 10673501 11883897 16713569 18246126
MAPKAPK5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 17624785 23685072 26295581 24818748 18568040 17254968
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
PPP1CA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16501611 16713569 15231748 15178317
AURKB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 20959462 27933271 20847049 15469940 32873634 22611192 27496712
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
MAPK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15187187 17145710 19436832 15140942 10212189 20506250 21614932 16393692 17254968 11274345
PPP1CC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 17274640 15178317 16501611
CDK5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 9372954 21317932 11483158 11740489 19413330 19664995 21600237 11554766 11709713 16552184 10884347 16377624 17591690 15866171 17287340 17967874 92065884 11780126 12064478 10570149 26146988 15701641 17117479 17108107 14702041
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP53 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18431400 25241761 15855171 18206965 19857493
TP53 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11238924 18431400 21508668 9891077
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
PPP1R13L TP63 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 22538442 12524540 18275817 24714389
TP73 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10648616 21245298 11172610 10435630
PPP1CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
GSK3B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
BTK BMX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12573241
BMX PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 27994061 18437915 21454698 21289086 16291744 22940691 12639965 17117420 23716717 28053086 16920701 16415178 20473329 20658524 21918175 15735019 23466867 17692050 16189514 15707572 20501847 12482769 11909938 16153436 20802517 14656986 15371459 11331870 14645233 16782899 15026417 15561106 14761895 17215324 19815712 25617365 11839772 27226554 29311227 17449913 12871985 17088251 17317726 22490227 12876384 18250445 18664639 32839549 21059620
SP1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18053089 11507078 22028617 15647279 11687969 10982796 12750289 15895377 10766860 9632722 15905358
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
AURKB BUB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12925766 14767480 15249581 16571674 17956729
AURKB MAPRE3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23712260 19696028
ATG5 ATG16L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20562859 23262492 22342342 20639872 23392225 12665549 23202584 18448665 25484072 28594407 10406794 21575909 22847423
GSK3B NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 29775963 26674355 29261130 22751928 23025925 16551619 23864927 28128361 22279539
CREBBP NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21196497 11683914 11154691
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
SP1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7636984 8450395 9151857 20538607 11964305
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9056676 9528780 15755876 7541912
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
PRKCZ RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11684013 21515635 15210811 21131967 12881425 34230209 16189514 17183360 33864076 27466442
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
RPS6KA4 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17183360 12628924 19933278
PPP1R13L RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12134007 10336463
GSK3B RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 18201972 15465828 15280197 22761446 20537194 21194439 19345186 21660967 19997086 16407239 25629551 17183360
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
TBK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12842894 17562815 15128824 15485852 10521409 15489227 15849198 14560022 19958770 12767944
RELA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12055073 7933095 10671503 20861353
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
HIF1A VHL â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
VHL HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
HIF1A EGLN1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EGLN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23487784 12839937 22075993 20574527 15563275 19628018 18072750 24558194 22451659 16157596
HIF1A VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12205091 15930297 21887475 22150821 22396654 15962286 23159849 17482131 17140440 16883594
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
HIF1A EGLN1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 16.0 1.0 Reactome 11292861 15652751 17182618 12615973 12788921 11598268 11292862 21335549 17434750 15474027 15247232 12351678 12912907 15987702 22286099 18337469
EGLN1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19604478 20840591 16511565 23413029 12351678 15474027 22946054 15652751 16407130 25361009 31763849 32755251 16391536 15721254 20724477 24145445 17353276 18264140 26611735
VHL HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 123.0 1.0 Omnipath 17145710 21332579 24857547 12682018 26496610 11292861 11024059 15060148 16278378 12586829 17353276 12004076 12205091 17339318 10823831 11226425 21602890 16862177 15611064 12351678 16140212 11865071 26037477 16611863 10973499 23401859 25361009 11331613 18305400 25438054 14691445 17047048 12538644 22932900 18985005 26735336 21358672 18323857 10878807 19147576 16511565 17973296 23413029 24316222 11986208 12808024 12464182 23318261 22369643 19940151 15721254 20724477 21335603 16391536 23387829 18694926 26743088 14556007 18264140 10353251 15082527 11358837 11292862 11566883 12050673 19123984 17558023 27281823 15805242 11641274 25500545 34174286 24899725 12606543 32535973 17132228 24015760 12086861 11504942 35589690 26215701 22351759 12925778 18222538 17986458 14600153 10944113 23580587 26611735 18426857 20049704
CSNK1D HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20699359
SP1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12759366 16574895 16790435 9458366 9415398 12169688 10949931 12694408 11562358
SP1 BTK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11254710 11779634 7721790 10362515 8562928
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
MAPK8 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28831131 22266860 18199680 19245816 25398907 17570479
PRKCZ SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23148884 16943418 18258854 19464346 27320013 17049555 20953893
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
TNK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22322295 11394904 25678401 20333297 10652228
CAMKK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14500673 11445557 12149249 10833263 9859994 9868760 9368760 11278835 10226025
PPP1CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
TBK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21329883 21464307 21106850
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 22619175 19369195 19737514 19940129 17932490 23431053 11805089 24872389 23893242 17726016
PRKACA NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
GSK3B NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 26999213 12871932 11425860 24618402 18669648 17693123
PRKACA NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19531803 12947093 17959673 15642694 15197457
GSK3B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
CSNK1D CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10500146
CDK5 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12202491 9122166 17202132
CDK5 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11160818 21825040 21378178 14712065 25525271 24091658 17096371 33999101 23294285 24121667 33981002 17185424 28361970 12941275 20519501
PRKCZ MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962008 8702918 18667433 17646398
PRKCZ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18353303 14657655 11481324
PRKACA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 28003367 23060444 25867080 21455600 30600261 1716180 28242698 19328185 32102849 92316961 19095655 14602047 7530719 10581361 11053017 9385646 25330774 15657296 1377674
PRKACA MAPKAPK5 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17947239 20734105 20849292 19166925
PRKACA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16543730 15845746 18691976 19836308 8524413 12054501 16039586 12147701 16522636 11035810 18669648
PRKACA CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11574071 11574070 10187789
MAPK11 MAPKAPK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15187187 23331499 18039929 9628874 23180781 19690332 12738796 11274345 18669648
MAPK11 RPS6KA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15187187 19436832 15140942 20506250 21614932 16393692 11274345
NEK2 PPP1CC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21382349 23080069 24902662 10880350
MAPK8 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 27042197 20028971