Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
POLA1 PCNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9660172 2165567
PCNA FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
HDAC1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18691180 9650586
E2F4 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15510213 18319725
E2F6 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15574595 18319725
PCNA REV3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19806028
MTA1 HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23791785 16511565
FEN1 POLD2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
RPA1 PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5222806 17673209
POLA1 PRIM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM2 PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM2 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
PRIM2 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
PRIM2 PRIM1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
FEN1 PRIM2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
H3C2 RBBP4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
E2F4 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
RPA2 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
RPA1 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
RPA3 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
RBX1 DTL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17588513 19481520
E2F4 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 POLA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 RFC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 POLE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 RFC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 FEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 RFC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 16135806
E2F4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12789259 18319725
E2F4 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F4 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15574595 18319725
E2F6 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 12909625
E2F6 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15574595 18319725
FEN1 POLD4 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
POLA1 FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
POLD1 FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
FEN1 PRIM1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
FEN1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
FEN1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
FEN1 POLA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
RPA1 FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592449
TOP1 LIG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 13679147
REV3L MAD2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22828282 8385420
POLA1 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
POLA1 PRIM1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
POLA1 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
RPA1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17666013 9214288
PRIM1 POLA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15132993 9115215
PRIM1 POLA2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15132993 9115215
POLD1 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 10852724
POLE2 POLE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 32296183
POLD2 REV3L â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
DDB1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24249678 26679995 25189618 34026424
POLD2 POLD3 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
ESR1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
APEX1 DNMT1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28986522 34079125
CUL4B RBBP4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23238014 34026424
RBBP4 MTA1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
HDAC1 E2F6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26496610
RPA2 ESR1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31527615 11953755
TULP3 RAD18 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 33187986
POLA1 PRIM1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
RFC3 RFC5 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
RFC2 RFC4 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
DNA2 FEN1 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
DNMT1 MTA1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
PCNA POLE â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
FEN1 POLD2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
FEN1 POLD3 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
MTA1 CUL4B â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 34026424 26028330
CUL4B HDAC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25189618 34026424
RFC2 RFC5 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PCNA APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10559261 11601988 16189514
RAD18 PCNA â—¼   UBIQUITINATION ✅ + 0.86 0.86 Signor 19706603
E2F4 HDAC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9724731 23060449 9858615 21102443
POLA1 PRIM2 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PRIM1 PRIM2 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
POLD2 POLD1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 31449058
DTL CUL4A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 30649446 17041588 21145461 16861906 21628527 31155351 16949367 30623174 29424068 23478441 31973889 23555860
FEN1 APEX1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11601988 16189514
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
POLD1 RPA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
RAD18 PCNA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21967848 28924044 21227930 20675655 32701997 21858012 20064529 28831681 33508099 17108083 18363965 23345618 26170230 17720710 24958773 15359278 31873223 18245774 30700555 31887036 30563767 20600238 22904075 31160570 27377895
PCNA DNMT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10888872 23708667 9302295 20613874 26496610 22606318 30301766 12354094 24958773 20940144
MTA1 CHD4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21670149 24440720 28977666 26344197 12920132 24981860 32744500 26028330 9885572
XRCC1 APEX1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28986522 19934257 11707423 16713569
HDAC1 TOP2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11062478 11136718
POLB XRCC1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
RAD18 DTL â—¼   KO_DOWN_REGULATES ✅ - -0.9 0.89 PKG 28854368
HDAC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14988403 11929879 16189514 16713569
REV3L PCNA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
XRCC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 30260704 20227374 16713569 34111398 15107487
PCNA MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
PCNA DTL â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16861906 25154416 21725088 30301766 30623174 29424068 20129063
E2F4 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17671431
E2F3 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15510213 18319725 11491305
MTA1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 21670149 34026424 24981860 16511565 22939629 26496610 9885572 27098840 26344197 21258344 10840944 14722073 26028330 12920132 33264408 17922035 28514442 16189514 26949739 18451879 11146623 23752268 20585571 29997244
MTA1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18451880 16807247 12167865 11146623 12639951 31527615
POLD2 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16000169 10852724 16510448
PRIM2 POLE â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM2 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRKACA H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11749379 9892015
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
E2F3 POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12748276 15574595 18319725
E2F3 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12748276 15574595 18319725
E2F4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17531812 12789259 20946668
E2F4 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15574595 18319725 16135806
E2F6 RBBP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12909625
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
RPA1 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
RPA2 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV1 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
RPA3 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
POLA1 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA1 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 8223465
POLE POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLE2 POLA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLA2 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
PRIM1 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
POLE4 POLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 6693436 10801849 9405441
PRIM1 POLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10882098 10757793 12045100
REV3L REV1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV1 REV3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15189446 18953031
REV3L RPA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV3L RPA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV3L RPA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
DNMT1 HDAC1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
RPA2 RPA3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
CHD4 MTA1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
POLA1 POLD3 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
POLD2 POLD4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
TOP1 TOP2A â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
RPA3 RPA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24126761
POLD3 POLD4 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CUL4A DTL â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
CUL4B DTL â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
POLE2 POLE4 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
POLD3 REV1 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
POLE3 POLE4 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
CHD4 RBBP4 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PCNA TOP1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
FEN1 POLD1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DNA2 RPA1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
POLE POLE4 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RFC2 PCNA â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 8093561 9228079 26496610 24958773 12171929
RFC5 PCNA â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 9228079 8999859 24958773 16189514 12171929
DDB1 DTL â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
HDAC1 DNMT1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22274925 10888886 15870198 21670149 17707923 10615135 26794444 17967891 20613874 12473678 17934516 23708667 27593931
RBBP4 HDAC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 21670149 24981860 22939629 26496610 34518534 11302704 11102443 27705803 17827154 10734134 10220385 9885572 10471499 26344197 21258344 12091390 9150133 16713569 11602581 12920132 20127688 9790534 17643391 11470869 19686092 12943729 9150135 28514442 16189514 27068747 10444591 19703393 11171972 15451426 23752268 20585571 9520398 11118440 31435636
DTL PCNA â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
PCNA SPRTN â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
POLE2 POLE3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
LIG3 XRCC1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
DNMT1 PCNA â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PCNA RAD18 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
POLE POLE3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPA1 RPA3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
LIG1 PCNA â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MAD2L2 REV3L â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
MAD2L2 REV1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RFC3 RFC1 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 9488738 14681455 26344197 22939629 18245774 8692848
PCNA RPA1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
HDAC1 MTA1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
REV1 REV3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
HDAC1 RBBP4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PCNA RFC5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MTA1 RBBP4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PRIM1 PRIM2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLD1 POLD4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
FEN1 PCNA â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLD2 POLD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLA2 PRIM2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLA2 PRIM1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLE POLE2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RAD18 UBE2B â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RFC1 RFC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPA1 RPA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PCNA RFC2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RFC2 RFC4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RFC3 RFC4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PCNA POLB â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
XRCC1 POLB â—¼   PHYSICAL_INTERACTION 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
POLB POLD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB FEN1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21183466 19778542 20573551 11440997 15731342 6278323 15193131
POLB RPA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB RPA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB PCNA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB LIG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9685411 12200445 19329425 8663274 11554294
POLB RPA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
PCNA POLB â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
XRCC1 POLB â—¼   SHARES_COMPLEX 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
XRCC1 POLB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 15107487 26186194 8978692 16442856 15520167 11467963 26496610 15367657 25423885 16713569
RPA2 PCNA â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA POLD4 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA FEN1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
PCNA REV1 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15189466 15703371 16337601 16337602 16697054 17035102 17517887 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 20227374 22021614 22266823 22562137 23065650 23414611
PCNA POLD2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA XRCC1 â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA POLD1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA LIG1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11756412 14624239 14726013 15703371 15871698 16697054 16731526 17088286 17116881 19208614 19364882 1974050 19847258 20056333 20603072 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA POLD3 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
RPA2 PCNA â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA FEN1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
PCNA POLD1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA LIG1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11756412 14624239 14726013 15703371 15871698 16697054 16731526 17088286 17116881 19208614 19364882 1974050 19847258 20056333 20603072 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA POLD3 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD4 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLD2 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA XRCC1 â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RAD18 PCNA â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10884424 15280666 15688063 16611994 16824193 17652783 18157158 18196958 18363965 18498753 19013543 19258535 19396164 20129063 20675655
PCNA POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PCNA POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
RAD18 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 18363965 19706603 17652783 18196958 18498753 20129063 21227930 10884424 19013543 18157158 15280666 19258535 16611994 19396164 20675655
LIG1 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12171929 9649448 28073635 10559261
PCNA FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 28514442 15576034 8668533 3113402 11601988 12853968 31467278 1477073 24958773 7673186 16216273 11313979 15616578 8876181 14657243 11430825 26496610 16189514 9305916 22606318 28073635 19153658 26751069 26186194 9178907 22592530 24728180 17115032 18692475 26030842 16326861 29997244 22556262 9545252 31515488
PCNA DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17991895 18384127 31235252 28073635 12354094 9302295
PCNA POLD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24022480 9038370 16510448
PCNA RFC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8999859 12400013 15225546 19285992 10353443 12192049 9649448 26496610 12045192 12171929 24958773 8861969 9092549
RPA2 LIG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 APEX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 RPA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 RPA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
LIG1 POLD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9649448 19223468 22952233 10959839
TOP1 LIG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14699148 13679147
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
POLD4 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLA1 POLD2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
APEX1 POLD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLD1 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD3 POLD2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD2 POLA2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD2 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 PRIM2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD2 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 UBE2B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD2 PRIM1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD4 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD3 POLD2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 POLA2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 PRIM1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD2 PRIM2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 9286699 12403614 16510448
POLD1 PRIM2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
PRIM2 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
PRIM2 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 PRIM2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRIM2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRIM2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
RPA3 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
CUL4A POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
CUL4A POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DTL CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21145461 19231300 16949367
DNMT1 H3C2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
SIRT6 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18337721 16439206 19408108
RPA2 APEX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
RPA1 APEX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 RPA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
FEN1 APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11601988 16189514
RPA1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
CUL4B POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
CUL4B POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
POLD1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD3 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
DDB1 POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
RPA1 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD1 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD4 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD3 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
E2F4 RPA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 11799066
E2F4 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 11799067
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
POLD1 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
RPA2 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
RPA1 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
RPA3 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
XRCC1 LIG3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
LIG3 XRCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 9705932 20227374 17353931 11163244 26496610 16713569 8264637 11352725 9136882
POLA1 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA1 POLD1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA1 POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLA2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA2 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA2 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 POLA2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA2 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLA2 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD4 POLD1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD1 POLD3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 PRIM1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD1 UBE2B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD4 POLD1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 PRIM1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD1 POLD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 12403614 16510448
UBE2B POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PRIM1 POLD3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
RBX1 POLD3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD4 POLD3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
POLD3 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
POLD4 POLD3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 27760120 27760777
PRIM1 POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
POLD3 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
PRKACA POLD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22148433
RBX1 POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
UBE2B POLD4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PRIM1 POLD4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLD4 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PRIM1 POLD4 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
RPA3 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
REV1 RAD18 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
REV1 RAD18 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
RPA1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RFC5 RFC2 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 9488738 9751713 33961781 24981860 26344197 9228079 22939629 8692848 28514442
RFC5 RFC4 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 9488738 9751713 28514442 33961781 32296183 24981860 26344197 9228079 22939629 29892012 8692848 9092549 26264872 25416956 16189514 30021884
RPA2 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 UBE2B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 SPRTN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23042605 16139798 24768535 23042607
RPA2 XRCC1 â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RPA2 RPA3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 UBE2B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 RPA3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 XRCC1 â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RPA2 RPA3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 SPRTN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23042605 16139798 24768535 23042607
RPA3 UBE2B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RAD18 DNA2 â—¼   KO_DOWN_REGULATES ✅ - -1.03 1.02 PKG 28854368
RAD18 POLA1 â—¼   KO_DOWN_REGULATES ✅ - -1.76 1.75 PKG 28854368
POLE3 POLE3 â—¼   KO_DOWN_REGULATES ✅ - -2.96 2.95 PKG 28854368
RAD18 RAD18 â—¼   KO_DOWN_REGULATES ✅ - -4.39 4.38 PKG 28854368
POLE3 POLE4 â—¼   KO_DOWN_REGULATES ✅ - -5.81 5.8 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368