Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
PCNA REV3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19806028
FANCD2 BRCA1 â—¼   COLOCALIZATION 2.0 0.8 intact 11239454 5213674
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
FANCD2 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
FANCI UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
REV3L MAD2L2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22828282 8385420
TP53 MSH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209975
RELA PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0701877104 17606919
TP53 POLI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10023689 10913176
TP53 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678112
RAD18 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
REV1 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
REV1 TUFM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 REV3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
TRIM25 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TRIM25 UBB â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
PCNA UBA52 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
MD2L2 CDC27 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23007861 17719540
REV1 RPS27A â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
UBB UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
UBC UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
BRCA1 RAD18 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25184681 29656893 23901102
RAD18 FANCD2 â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
POLI UBA52 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRCA1 FANCD2 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 12485996
FANCD2 RPS27A â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
RAD18 RPS27A â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
FANCI UBC â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
FANCI UBB â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
UBA52 UBE2L6 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
REV1 UBB â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS27A TRIM25 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
TRIM25 UBC â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
POLI UBB â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
FANCD2 UBB â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
POLH UBC â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
RAD18 PCNA â—¼   UBIQUITINATION ✅ + 0.86 0.86 Signor 19706603
UBB RAD18 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28506460 24981860
BRCA1 MSH2 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
PCNA UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
ISG15 UBA7 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
POLI RPS27A â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
DPOD3 REV1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26982350 23254330
CA086 REV1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26318859 22266823
REV1 FHL2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 16713569 10906324
UBA7 ISG15 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 17597759 32296183 14976209 16189514 18356159 16009940 16884686 22693631 25416956 20975683
UBC POLH â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17304240 16763556
BRCA1 RPA1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
REV1 UBC â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PCNA UBB â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
RAD18 PCNA â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21967848 28924044 21227930 20675655 32701997 21858012 20064529 28831681 33508099 17108083 18363965 23345618 26170230 17720710 24958773 15359278 31873223 18245774 30700555 31887036 30563767 20600238 22904075 31160570 27377895
RPS27A UBE2L6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
FANCI RPS27A â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DPOD3 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10219083 26496610 16763556 15576034 16000169 11328591 24695737 16510448 11595739 12171929
POLI PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15342632 11724965 33166398 34165573 23248005 16763556 18931444 26903512
REV3L PCNA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
PCNA MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
MD2L2 DPOLZ â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20164194 20054135 22859296 30254264 20088965 30022168 22303021 21926160 32332881 10660610 30154076 30111544 11485998 22828282
REV1 DPOLZ â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20164194 22303021 21926160 30111544 15189446 22828282
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 FHL2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14550570 14986435 21988832 25184681
BRCA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17873885 11320250 14636569
TP53 FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18615633 11062252 22796152
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RPA1 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
RPA2 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV1 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
RPA3 MAD2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
MAD2L2 POLI â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
TP53 MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350971 8630028
PIAS4 RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20016603
REV3L POLI â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV3L REV1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV1 REV3L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15189446 18953031
TP53 REV3L â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
REV3L RPA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV3L RPA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
REV3L RPA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15254543 16819516 15199127
RPA2 RPA3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
MSH2 PCNA â—¼   PHYSICAL_INTERACTION 909.0 0.9 STRING 36370105
RPA3 RPA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24126761
POLI REV1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
POLH REV3L â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
REV1 POLK â—¼   PHYSICAL_INTERACTION 0.93 0.93 HIPPIE 26982350 19170759 15189446 15380106 26903512
RAD18 UBB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
POLD3 REV1 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
PCNA RPS27A â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
PCNA MSH2 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 8858149 16189514 12171929 15225546
FANCD2 UBC â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
POLI UBC â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
POLH PCNA â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 23761444 21855803 23388460 28831681 22989887 20129057 23042605 26988343 21791603 23345618 11585903 27770570 20159558 16763556 15149598 16189514 30963698 15342632 31796584 24474685 25766642 30563767
REV1 MD2L2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 20164194 23287467 22859296 22303021 12529368 21690293 21926160 15380106 30154076 30111544 11485998 15189446 22828282
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PCNA RAD18 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPA1 RPA3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPS27A TP53 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MAD2L2 REV3L â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
TP53 FHL2 â—¼   KO_DOWN_REGULATES ✅ - -0.99 0.98 PKG 28854368
MAD2L2 REV1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
POLH REV1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PCNA RPA1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
C1ORF86 UBC â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
REV1 REV3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPA1 RPA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RAD18 UBC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPA2 PCNA â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA POLI â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
PCNA FANCD2 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA FANCI â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA REV1 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15189466 15703371 16337601 16337602 16697054 17035102 17517887 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 20227374 22021614 22266823 22562137 23065650 23414611
PCNA POLH â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15703371 16337601 16337602 16697054 17035102 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 22021614 22266823 22562137 23065650 23414611
PCNA POLK â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11900249 12466554 12648680 12930902 14624239 14657033 14726013 15189446 15189466 15459660 15703371 16697054 17035102 17116885 17296725 17582221 17652783 17884153 18087292 18157158 18196958 18584027 18677104 18809224 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22266823 22743550 23065650 23414611 24050180 8264637 8978692
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD3 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
RPA2 PCNA â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
PCNA POLI â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
PCNA POLK â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11900249 12466554 12648680 12930902 14624239 14657033 14726013 15189446 15189466 15459660 15703371 16697054 17035102 17116885 17296725 17582221 17652783 17884153 18087292 18157158 18196958 18584027 18677104 18809224 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22266823 22743550 23065650 23414611 24050180 8264637 8978692
PCNA FANCD2 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD3 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA POLH â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15703371 16337601 16337602 16697054 17035102 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 22021614 22266823 22562137 23065650 23414611
PCNA FANCI â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
RAD18 PCNA â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10884424 15280666 15688063 16611994 16824193 17652783 18157158 18196958 18363965 18498753 19013543 19258535 19396164 20129063 20675655
PCNA POLD3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
RAD18 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 18363965 19706603 17652783 18196958 18498753 20129063 21227930 10884424 19013543 18157158 15280666 19258535 16611994 19396164 20675655
PCNA POLH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20129057 20159558 24474685 16357261 16189514 19208623 30963698 15342632 21855803 15149598 23042605 21791603 23761444 23345618 16763556 11585903 23388460 25766642 26988343 27770570
PCNA POLI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16763556 26903512 15342632 23248005 11724965 19208623 16357261 18931444
BRCA1 FANCD2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCI â—¼   PHYSICAL_INTERACTION 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCD2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 FANCI â—¼   SHARES_COMPLEX 55.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
BRCA1 FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12887909 12485996 11239454 25652403 14499622 16713569
BRCA1 FHL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 14550570 25184681 14986435
FANCD2 FANCI â—¼   PHYSICAL_INTERACTION 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCD2 FANCI â—¼   SHARES_COMPLEX 66.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
FANCI FANCD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21719678 22855611 24451376 17460694 27773793 20603015 25168188 19561358 18931676 24623813
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
UBE2L6 ISG15 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269
POLK MAD2L2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 3941892 12952891 22721435 19492058 12145297 22772988 10887153 15475561 11058110 20660785 24648516
POLD3 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
REV1 POLH â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10884424 11756412 12466554 14624239 14657033 14726013 15189446 15688063 15703371 16337601 16337602 16611994 16697054 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 1974050 19847258 20129063 20675655 22021614 22266823 22562137 23065650 23414611
POLH RAD18 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
REV1 POLH â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10884424 11756412 12466554 14624239 14657033 14726013 15189446 15688063 15703371 16337601 16337602 16611994 16697054 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 1974050 19847258 20129063 20675655 22021614 22266823 22562137 23065650 23414611
POLH RAD18 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
POLH REV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22828282 19170759 15189446 34725419 24409475 22691049 19157994 16824193 21690293 15380106
REV1 POLI â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
REV1 POLI â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
REV3L POLK â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 3941892 12952891 22721435 19492058 12145297 22772988 10887153 15475561 11058110 20660785 24648516
RPA2 POLK â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
POLK REV1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15189466 15703371 16697054 17035102 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 20227374 22021614 22266823 23065650 23414611
RPA2 POLK â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
POLK REV1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11756412 12466554 14624239 14657033 14726013 15189446 15189466 15703371 16697054 17035102 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 20227374 22021614 22266823 23065650 23414611
RPA3 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 RAD18 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
REV1 RAD18 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
REV1 RAD18 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 10884424 12466554 14657033 15189446 15688063 16337601 16337602 16611994 16824193 17035102 17652783 18157158 18196958 18363965 18931676 19013543 19217833 19225445 19258535 19396164 19622404 19686080 20129063 20675655 22266823 22562137 23065650
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
RPA2 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
UBE2L6 UBA7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269
RAD18 RAD18 â—¼   KO_DOWN_REGULATES ✅ - -4.39 4.38 PKG 28854368
MSH2 MSH2 â—¼   KO_DOWN_REGULATES ✅ - -6.48 6.47 PKG 28854368