Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
UBA52 ZRANB1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
CBX6 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7998286 20601937
HMGN1 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
UBA52 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC4 ERCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC4 FLNC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC4 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003064107 20498094
HDAC1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18691180 9650586
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
CAV1 CAVIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001640 24013648
CAVIN1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001640 24013648
TP53 RPS27L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
PARP1 CUL4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
ABL1 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19231300
ENSG00000258838 ERCC6 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
KDM4B H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22373579 8387631
SMARCA5 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218974 16917504
UBA52 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16628214 5218530
H4C6 RBBP4 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H4C6 KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
PARP1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
HDAC1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10220385
KAT2B H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880483
ABL1 DDX41 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20808760 1000457
ABL1 CUL7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FLNC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 POLD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
RIF1 AKR1C3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
OGG1 APEX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11139613 25086253
APEX1 OGG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20185827 17203305
TP53 ATF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 ATF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SNCA ATF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEBPB ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16989641
NFKB1 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24100018
BAX SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMARCA1 BAZ1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SMARCA5 BAZ1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19092802 19234442
BMI1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6948569 19233177
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
BRCA1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12700228
CEBPB KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23456364 17301242
CEBPB MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9743233 22139077
CEBPB SCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17387171 20352127
CEBPB TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8524227
RNF11 COPS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
COPS3 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
COPS6 VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PARP1 CUL4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
PARP1 DDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
DDB1 HIST1H2AB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
DDX17 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17226766
DOT1L UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ERCC3 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ERCC5 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8652557
XPA ERCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17948053
IKBIP ERCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ERCC6 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ERCC6 RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ERCC6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16319174
ERCC8 XPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8999876
ERCC8 HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16916636
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
NFKB1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
HDAC1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20609221 22422937
HMGN1 KAT2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16096646
TP53 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24366007 21552291
TP53 KDM4B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28073943
RAD50 NBN â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
TP53 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22103682 8291914
NCL RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15743838
PARP1 SPTA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
PARP1 RBX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
TP53 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11375983
POLI RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TP53 POLI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10023689 10913176
TP53 PRNP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24339999 19064990
SF3B2 PRPF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PRPF3 UBL5 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PRPF4 UBL5 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
RBX1 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
RIF1 VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBA52 RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
UBC RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
RNF11 RPS27A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RPS27A USP7 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
USP7 RPS27A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 26235645
TP53 SCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
SF3B1 UBL5 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
XAB2 SF3B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3B2 UBL5 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBB SFPQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SFPQ UBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBA52 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA VIM â—¼   COLOCALIZATION 2.0 0.8 intact 16678164 5218597
VIM SPEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11807984 16567167
SSBP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19066201
USP7 TP53 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 5215220 11923872
UBA52 USP7 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 26235645 9521656
USP7 UBA52 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 26235645
VAC14 VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
COPS4 CUL4B â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 UBC â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 UBB â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 RPS27A â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
DOT1L RPS27A â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
DOT1L HIST1H2AB â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
DCLRE1A ANXA1 â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
HDAC1 SMARCA5 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
RAD50 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 10426999
ERCC6 POLI â—¼   KO_DOWN_REGULATES ✅ - -0.81 0.8 PKG 28854368
ERCC6 SKP2 â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
BAX P53 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 21712378 32064756 25241761 25115399
ERCC6 UBP7 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 22032989 26030138 31775559
RPB1 CSTF1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 9002523 11459828 29180510
MDM2 ATF3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 34114479 31796886 20592017 15933712 29225035
DDB1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24249678 26679995 25189618 34026424
GATAD2B RBBP4 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
ERCC6 VWDE â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
NBN FLNC â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
ERCC6 RPS27A â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
ERCC6 UBB â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
DOT1L UBC â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
DOT1L UBB â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
ERCC6 SYNE2 â—¼   KO_DOWN_REGULATES ✅ - -0.82 0.81 PKG 28854368
PCNA UBA52 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
HIST1H4A UBA52 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
CUL4A NFKB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30945288 21145461
CUL4A DDX5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32235678 21145461
UBB P53 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17936559 23443559
ERCC3 UBP7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
UBB UBP7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27452404 12507430
CUL4B UBP7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34026424 21145461
NOP56 HNRPU â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 12777385
HNRPU ERCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26496610 26030138
BRCA1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26831064 34079125
ESR1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
APEX1 RIF1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28986522 34079125
APEX1 SFPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939629 28986522
APEX1 NOP56 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28986522 34079125
CEBPB ATF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20110283 20102225
BMI1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 20668194
ESR1 CAND1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
ERCC6 CRIP1 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
MDM2 CUL4B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 22032989
CUL4B DDX3X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34026424 21145461
CUL4B UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 21145461
CUL4B RBBP4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23238014 34026424
CUL4B SFPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 34026424
SKP2 CUL5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21119685 21145461
DDX17 SFPQ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34133714 26344197
DDX41 DDX23 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25920683 34079125
ESR1 DDX3X â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20308691 19805454 21182205 20348541
ERCC6 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32355176 16107709
KDM4B ESR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30418174 21502505
NOP56 TOP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12777385 34079125
RNF11 UBC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15231748 20676133
SKP2 UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ERCC6 SNCA â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
CTR9 POLR2B â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
DDB1 HIST1H4A â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
DDX23 SF3B2 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
UBB ZRANB1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
HIST1H4A UBC â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
HIST1H4A UBB â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
HIST1H4A RPS27A â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
CUL5 TCEB3 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
ERCC6 FHL2 â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
CBX6 HIST1H3A â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
P53 RBX1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30349055 23443559 22653443
BMI1 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 34316702 24457600 20668194
ERCC6 MMADHC â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
ERCC6 GRAMD1A â—¼   KO_DOWN_REGULATES ✅ - -0.84 0.83 PKG 28854368
BRCA1 RBBP8 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 16818604
RBBP8 BRCA1 â—¼   RELOCALIZATION ✅ + 0.83 0.83 Signor 24832651
DDX17 SFPQ â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
ATF3 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
GATAD2A GATAD2B â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
HDAC1 SFPQ â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NCL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
POLI UBA52 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RPA1 XPA â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
USP7 UVSSA â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ATF3 MDM2 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
HIST1H2AB HIST1H2BB â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
DDB1 HIST1H3A â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
NONO SFPQ â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
KAT2B MDM2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
PSMC5 VCP â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
SF3B2 SFPQ â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
CBX6 BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 24981860
RL10 ERCC6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31722399 26496610
CDK4 P53 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28218424 28205554 28628118
DDX17 P53 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15660129 32807901
ESR1 UBP7 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 23403292 31527615 31518603
CUL5 RPB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 19037258 30349055 21145461
BRCA1 H2A1B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32092106 33589814 25131202 29367421 34321665 25355358
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
TOP1 DDX23 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15848144 34079125
MTA2 EHMT2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 26028330 18451879
ESR1 EHMT2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21984853 31527615
ESR1 MTA2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 18451880 16645043
HIST1H2AB HIST1H4A â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
TOP1 NONO â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15848144 24981860
XRCC5 TOP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21679440 28415827
ERCC6 HMGCR â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
COPS6 DDB1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DDX5 ESR1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DOT1L HIST1H4A â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
HIST1H2AB HIST1H3A â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
DDX23 SF3B1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H2BB HIST1H4A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H3A MPHOSPH8 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H3A HIST1H4A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H4A HIST2H2AC â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
ERCC6 CDC26 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
ERCC6 CHTF8 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
NBN SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
CAND1 CUL5 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MDM2 UBA52 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
COPS4 DDB1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
ESR1 RL10 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 23403292 31527615 21182205
P53 UBC â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 17170702 17268548 17290220 18566590 19098711 19619542 19536131 18388957 17139261 17568776 18309296 17159902 19798103
ERCC2 RPB1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 32355176 27193682
BRCA1 TOP2A â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25184681 15965487
CUL4B HDAC1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25189618 34026424
HDAC1 ERCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 31722399 26496610 26030138
ESR1 NONO â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33731348 25604459 31527615 20348541
ESR1 PSMD1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 25604459 20348541
UBC MDM2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18566590 19166840 17290220 19098711
HNRNPU POLR2A â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
COPS4 COPS6 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
MDM2 UBB â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
PSMD1 VCP â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
RPS27A ZRANB1 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
POLI UBB â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
ERCC6 UBC â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
ERCC6 GPC4 â—¼   KO_UP_REGULATES ✅ + 0.85 0.85 PKG 28854368
HIST1H3A HIST1H4A â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PCNA APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 10559261 11601988 16189514
P53 APEX1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15824742 16189514 16713569 9119221
HNRPU RPB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 18710935 15711563 21235343 10490622
ESR1 RPB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20308691 31527615 16957778 20348541
RPB1 ERCC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20541997 32355176 16916636 34108663 9372911 26620705 10944529
BAZ1B ESR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12837248 31527615
CUL4B DDX5 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28225217 21145461
ESR1 MEN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 16651450
ESR1 FHL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 15666801
PARP1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19470756 34079125 16204234 20596014
PARP1 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20085707 34079125
TCEA1 SF3B2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 17643375 22939629
XRCC5 TOP2A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20085707 12393188
ERCC2 XPA â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
PCNA UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
COPS3 RBX1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
HIST1H4A SMARCA5 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
PSMB5 UBB â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
PSMB5 UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
ERCC4 RPA1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
MRE11A RPA1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
COPS4 CUL4A â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
NCL TOP1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
PSMB5 UBA52 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
PSMC5 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD1 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD12 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD12 UBC â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
POLI RPS27A â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
DDX5 P53 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 32807901 15660129 20818423 24219989 25144556 23443559
P53 ABL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 10713716 16713569 10629029
CDK4 BRCA1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9244350 16713569 17334399 12509456
BRCA1 MRE11A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX17 DDX5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NOP56 DDX21 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26496610 12777385 34079125
HDAC1 EHMT2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 16287849 26496610 23752268 28514442 26028330
XPA ERCC6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20541997 8999876
ERCC6 ERCC8 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GATAD2A MTA2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PARP1 NFKB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25609649 16799643 16204234 11590148
UBB RNF11 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 14755250 33961781
UBA52 USP7 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK2AP1 GATAD2B â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ERCC3 TCEA1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMB5 RPS27A â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMC5 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMD1 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMD3 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMD12 UBA52 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CDK2AP1 GATAD2A â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PSMD12 VCP â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 RPA1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
GATAD2B HDAC1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
GATAD2B MTA2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
ERCC6 RHOT1 â—¼   KO_DOWN_REGULATES ✅ - -0.88 0.87 PKG 28854368
ERCC8 CUL4A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12732143 29225035 21145461 26826127 29531219 16751180 16949367 31973889 22902626
CUL4A ERCC8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
P53 TOP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8639538 11805286 16713569 10468612 18697815 32807901
P53 ERCC2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 7663514 16713569 8612585 16189514
BMI1 UBP7 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20601937 25605328 20800574
DDX5 RPB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12527917 29884807 17011493
H2A1B ERCC6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11003660 30021884
COPS6 COPS3 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 24421388
ERCC8 CUL4B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 21145461 29531219 26496610 16949367 31973889 22902626
ERCC6 ERCC5 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8652557 16916636 16713569 16246722
HIST1H2BB HIST1H3A â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
NFKB1 SFPQ â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 14743216 22536447
SFPQ TOP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15848144 24981860 9756848
ERCC6 STAP2 â—¼   KO_DOWN_REGULATES ✅ - -0.89 0.88 PKG 28854368
ERCC6 PRNP â—¼   KO_UP_REGULATES ✅ + 0.88 0.88 PKG 28854368
CUL7 RBX1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MRE11A RBBP8 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
NBN RBBP8 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
XRCC5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
COPS3 CUL4A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COPS3 CUL4B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COPS3 DDB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
POLD1 RPA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCNA UBB â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
GATAD2A HDAC1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PCNA ERCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10408173 16189514 9305916 16713569
MTA2 P53 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12920132 32807901 11099047
P53 ERCC3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16189514 12379483 16713569 8612585 7663514 32807901
P53 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 17545634 26556313 10766163 16713569 21761334
P53 TOP2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10666337 32807901 16713569
P53 HDAC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 14976551 20075864 17827154 19011633 10521394 16697957 10777477 16107876 11099047 32494626 16959611 11313951 12426395 18765668 22266186 19303885 25241761 26539911 20633551
RPB1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9159119 29513652 14506230 12955082 10725406 11504724 16713569 15886201 18197258 22990118 29180510 25184681 27583302
BMI1 H2A1B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26468281 29386386 34316702 33589814 27832544
BRCA1 ABL1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12024016 17352427
RBBP4 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220405 26831064 16713569
CSTF1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11278247 29180510 11257228
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10426999 29656893 10783165 11504724 25659039 25939603 25184681 19244116 18171670 12124328
HDAC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10220405 21102443 16713569
TP53 CUL7 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8415349 22653443
ERCC8 DDB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12732143 22232169 26826127 29531219 17392787 16751180 16949367 31970402 28416769 22902626
DDX17 HDAC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15298701 16189514 19995069 20663877
HDAC1 DDX5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 19995069 20022962 17369852 15298701 20663877
MDM2 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12897156 17545634 10766163 11178989 16713569 31012223
HDAC1 TOP2A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11062478 11136718
CDK2AP1 HDAC1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
COPS6 CUL4A â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS6 CUL4B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ERCC6 VIM â—¼   KO_UP_REGULATES ✅ + 0.89 0.89 PKG 28854368
HDAC1 NFKB1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
NONO SFPQ â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
ERCC6 PPM1H â—¼   KO_DOWN_REGULATES ✅ - -0.9 0.89 PKG 28854368
BMI1 CBX6 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ERCC2 TCEA1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
PSMC5 UBC â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
PSMD1 UBC â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
HDAC1 PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14988403 11929879 16189514 16713569
POLI PCNA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15342632 11724965 33166398 34165573 23248005 16763556 18931444 26903512
ERCC6 CUL4A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
CUL4A CAND1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12504026 16964240 21145461 12504025 27203177 21249194 18606781 17079684 22405651 15448697 19295130 31973889 22474075 12609982
UBP7 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31492752 25283148 21170034 31666375 30067985 22653443 22056774 11923872 26460617 31647545 20713061 30651545 16845383 16402859 16713569 17380154 23382381 23388826 20816748 29748603 26238070 22084066 21845734 17525743 16474402 17268548 32587091 29795372 14506283 15916963 32807901 24462112
ATF3 P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24554706 16189514 11792711 16169070 31796886 16713569 15933712
KAT2B P53 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 20589832 17189186 16537920 14614455 12501250 10891493 17977830 9744860 19680552 10490106 15965232 9891054 16959611 16678111 12068014
P53 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14978302 9582019 14710355 21742769 18501503 9482880 14636569 9926942 16677609 26140185 19509300 15571721 16713569 16969499 31073355
P53 CUL7 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 35140242 31152661 17229476 16547496 31343991 22653443 16875676 25609649 17298945 26186194 31570706 17332328 24711643 25003318 28514442 23443559 17942889
P53 ERCC6 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22032989 7663514 16713569 10882116
P53 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12898523 14627987 9565608 32807901 16713569 9312059 23169665 15044383
MDM2 UBP7 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26971997 34799561 18566590 29236775 22056774 26460617 31647545 17936559 20713061 16845383 16402859 28406480 17380154 20816748 26238070 29295817 16474402 27452404 28196907 15916963 16943424 24462112
ERCC6 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11003660 16772382
ABL1 MDM2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12110584 25624478 16702947
COPS6 ANXA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 APEX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18208837
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 FHL2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14550570 14986435 21988832 25184681
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17873885 11320250 14636569
CAND1 RBX1 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 12504025 12504026 15537541
CAND1 SKP2 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 12504025 12504026 15537541
CAV1 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 23634843 11563984 22230296 19595769
ESR1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12138116 18414489
PRNP CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10988071 16713569
SNCA CDK4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NFKB1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24296733 18425349
MAPK6 COPS6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ERCC6 CUL4B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
RBX1 CUL7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17332328 24793695 24793696
CUL7 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ERCC6 DDB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
ESR1 DDX17 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11250900 25604459 19995069 20663877 21182205 12738788 20348541
TP53 DDX3X â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24180280 23584477 21325288
TTF1 EHMT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16186106 18656484 12419226
ERCC6 EHMT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16186106 18656484 12419226
ERCC5 ERCC2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8652557 16189514 16713569 32245994
TP53 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8612585 16713569 7663514
RPA1 ERCC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
ERCC5 ERCC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
RBX1 ERCC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
ERCC6 TTF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16186106 18656484 12419226
ESR1 HMGN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8700510 17938209 18414489
ESR1 GSN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
TP53 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8090761 10029407
TP53 FHL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18615633 11062252 22796152
NFKB1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19752329 8016102
UBA52 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK6 RPL10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NFKB1 MEN1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11526476 16713569 16651450
MRE11A XRCC5 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MTA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11099047
OGG1 NEIL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15260972 11904416 12097317
SFPQ NONO â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 34017080 11259580 24981860 26344197 22939629 25959826 18042045 31815296 12403470 30725116 21988832 17507659 28514442 30445466 17452459 30021884
TOP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15247263 15848144 34079125
RPA1 RAD50 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA1 RBBP8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA1 VCP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22902628 23042605 23042607
PSMD3 UBC â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PSMD3 UBB â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ERCC6 ALKBH7 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
GATAD2A RBBP4 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
ERCC3 POLR2B â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PRPF4 SF3B2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMC5 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMD1 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMD12 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMD3 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
SF3B1 XAB2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
COPS6 RBX1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
ERCC6 ACO1 â—¼   KO_DOWN_REGULATES ✅ - -0.91 0.9 PKG 28854368
KAT2B RPB1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 9710619 18710935
KAT2B TP53 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
XPA ACO1 â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
HIST1H3A RBBP4 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
BAZ1B SMARCA5 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
TP53 USP7 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
PSMD1 PSMD12 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
CAND1 CUL4A â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
TOP1 TOP2A â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
MDM2 USP7 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
ERCC2 POLR2A â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
ERCC2 POLR2B â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
ERCC6 POLR2A â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
NBN NEU1 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
SF3B2 XAB2 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
PSMD1 PSMD3 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
PSMD12 PSMD3 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
ERCC6 MRFAP1 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
COPS4 RBX1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
UBC VCP â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
NBN RAD50 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ERCC4 XPA â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
PCNA RPS27A â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
RPB1 CTR9 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 26902284 26496610 16024656
BRPF1 HIST1H3A â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
MTA2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 6613464 18451879
UBB USP7 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
RPS27A USP7 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
PRPF3 SF3B1 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
RBBP4 SMARCA5 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
DCLRE1A SLC16A3 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
ERCC6 PCCB â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
ERCC6 BRPF1 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
PCNA TOP1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
POLR2A SMARCA2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPL10 UBA52 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27 RPS27A â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27 UBA52 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ERCC6 ECHDC3 â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
MRE11A NBN â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RBBP4 SMARCA1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
HDAC1 MTA2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CTR9 POLR2A â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
POLR2B TCEA1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
RPL10 RPS27A â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SF3B2 SF3B1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 12234937 28541300 26344197 10490618 24981860 22939629 21981285 32152280
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
CAND1 CUL4B â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
PRPF3 SF3B2 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ERCC6 SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
ERCC3 POLR2A â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PRPF4 SF3B1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
MTA2 RBBP4 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
POLI UBC â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
ERCC6 PPM1A â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
MDM2 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.96 STRING 36370105
P53 MDM2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21317885 11839577 23201157 21316347 25312347 22975381 17369817 21084285 30005830 23443559 21465263 10980696 17936559 10488081 16845383 21149449 22366412 23483203 29549180 14741215 26673821 11713288 18665269 15058298 29524278 28514442 22510990 25241761 22525275 19106616 22467867 25954860 10889512 16595680 24998844 15848166 28628118 28362432 17116689 33650658 14499615 24980433 10608892 26876197 17438265 22103682 22374672 16055726 7689721 17363365 19411066 12167711 23318437 18566590 31796886 30244831 12944468 23261415 27215386 27826076 11178989 19223463 17301054 9724739 32894144 21075307 29121928 19305137 17318220 20659896 20080206 7686617 11744695 18467333 23246961 23150668 23776465 16215989 9223638 16331255 31968249 17908790 14702041 15094782 11278372 28605833 31647545 24200963 10601022 21454483 27893708 21088494 32516735 16861890 26238070 20705607 21887275 19303885 25609649 12915590 31406141 27282385 25156994 23671280 15358376 23609977 25168242 19071110 22991965 22653443 22920093 7926727 17470788 26908445 27856536 26475964 19857530 11709713 11714701 30532073 19411846 11094089 20173098 17591690 9582019 12552135 20542919 28205554 14704432 15001357 29876924 25417702 23880345 20124408 19033382 22487680 30598450 33061576 22575647 9131587 17159902 31152661 17297477 9271120 25384516 24659749 21261729 12529318 22411991 14671306 22084066 20395212 21986495 29487367 33355139 23802716 23370271 23946421 22083959 32807901 15154850 29670376 27905468 35140242 25283148 22085928 11562347 10640350 19098711 32901886 21726810 25624478 25637791 21584881 16870621 12690203 12612087 15824742 11572869 25464845 26203195 22157679 30454706 28082682 9809062 17302414 19085961 24567357 25362358 17080083 17426254 15242646 22524527 29295817 16751805 11431470 26882543 30097011 18604177 20591651 22948151 24462112 10827196 20479273 31533005 22389628 21170087 20694676 17666403 11597128 33503543 14596917 18332869 10321734 21857681 16579792 16414131 18264029 21071676 30464405 17989425 20234175 10681559 27308622 19816404 30355102 19805293 9824166 25313037 16173922 24926618 16159876 26540344 18541670 32904724 17616658 12842086 26720344 27129163 22266868 27031960 32528731 22737255 15604276 16432196 19188367 1614537 22914926 24842904 15247280 32097779 23252402 17347673 16964247 17310983 22331460 30584071 22032989 24240685 31652301 10435614 24621507 24361594 15308643 32334023 16547496 20639885 17139261 15933712 21478269 15313915 23402884 21750659 11112690 19255450 22124327 25277184 19234109 21965653 27336364 15122315 22916255 22262183 15295102 31092600 25512388 16713569 26001071 27807478 31940492 20588255 20174603 20570896 20708156 27886165 17056014 19081178 29547122 23572512 16905769 15542844 19941302 10561590 28542145 32066565 16212962 10202144 28549433 10734067 21572037 18172499 9363941 15550400 17380154 10892746 14559824 22227409 18316739 33495326 17234751 15280377 31177307 24127580 19160491 17290220 8875929 12381304 16857591 18813780 10347217 21561866 24413661 31066983 20847049 21098709 25103245 8058315 22807444 30832340 21268072 20962272 26350565 30175854 20591429 22444248 32427887 16023600 24667498 11351297 11285227 11223036 18784078 11384992 10562557 19568783 31138778 21925390 11486026 19597489 9450543 31665549 22318540 27106262 24207125 15950904 18223694 23728348 22474335 34362424 22912717 20047188 14612427 14517261 30679555 18815136 18061646 28394340 34408321 18309296 11046142 15144954 12897156 23776060 15210108 27811966 19357310 22391559 16338390 29899406 34040386 26186194 11284721 15908921 23652204 33765973 31626714 17848574 9529249 25739118 30879903 10766163 15013777 22588298 18981217 29755129 30320499 11070080 22301280 27543608 30948704 19590512 15558054 12867035 24488098 27462439 18485870 17268548 22819825 31591476 23826318 21471462 9278461 16866370 22659184 19166840 20660730 29269425 31239268 32198344 25543083 17875722 10196247 15053879 21084564 16107876 16678796 17098746 19656744 30109812 11925449 17525743 16624812 30455251 19153082 28553961 21132010 26578655 32874188 31903119 29997244 19837670 20837658 26883110 21060154 33961781 33579943 20235143 15064742 26556313 22745160 20657550 20484049 16152627 11697899 18234963 24314634 12208736 30320919 11713287 28223335 30252118 10722742 31594538 19483087 22266850 24643130 20959462 33020477 21988832 12426395 19332559 23169665 12620407 23134341 27249653
RPB1 TCEA1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 17643375 16916636 22939629 9765293 20562857 20178742 23748380 9305922 12914699
ERCC3 ERCC2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 15220921 27193682 16669699 33381997 22939629 26340423 8152490 8652557 9118947 22678362 19934020
RBBP4 HDAC1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 21670149 24981860 22939629 26496610 34518534 11302704 11102443 27705803 17827154 10734134 10220385 9885572 10471499 26344197 21258344 12091390 9150133 16713569 11602581 12920132 20127688 9790534 17643391 11470869 19686092 12943729 9150135 28514442 16189514 27068747 10444591 19703393 11171972 15451426 23752268 20585571 9520398 11118440 31435636
USP7 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6799761 18566590
RAD50 NBN â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 24981860 19197236 22939629 12679336 10426999 26344197 17526493 9705271 12607003 17612497 12447395 22464731 34348893 11062235 15758953 12124328 11238951 26215093 23530059 15734743 16391231 24651726 30179224 17500065 30440001 22941933 10783165
USP7 TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5215220 11923872
TP53 USP7 â—¼   DEUBIQUITINATION ✅ 0.97 0.97 mint 5215220 11923872
CAND1 RBX1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
DDX23 PRPF3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MDM2 RPS27A â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
DDX23 PRPF4 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
NBN SCD â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
NBN ANXA1 â—¼   KO_UP_REGULATES ✅ + 0.97 0.97 PKG 28854368
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
CDK4 PCNA â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
UBC USP7 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BRCA1 RBBP8 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RPL10 RPS27 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL5 RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
HIST1H3A KAT2B â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DDB1 ERCC8 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
PSMB5 PSMD3 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
RPS27A TP53 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
TP53 FHL2 â—¼   KO_DOWN_REGULATES ✅ - -0.99 0.98 PKG 28854368
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PSMB5 PSMD1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
PSMB5 PSMD12 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
PCNA RPA1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PSMB5 PSMC5 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BRCA1 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
XPA ANXA1 â—¼   KO_DOWN_REGULATES ✅ - -1.0 0.99 PKG 28854368
ERCC6 RPS27L â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
HDAC1 RBBP4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MRE11A RAD50 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2A TCEA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS3 COPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC5 PSMD1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC5 PSMD12 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMC5 PSMD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD1 PSMD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD12 PSMD3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B1 SF3B2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS3 COPS4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS4 COPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ERCC6 RPS27 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMD1 PSMD12 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERCC2 ERCC3 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PRPF3 PRPF4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PCNA CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA PARP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA POLI â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
PCNA POLD1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA POLI â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11756412 12466554 14624239 14726013 15189446 15703371 16697054 17035102 17652783 18196958 18931676 19258535 19622404 19686080 1974050 19847258 22021614 23065650 23414611
PCNA POLD1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611
PCNA PARP1 â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
ERCC5 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18079701 10408173 16713569 19279666 9305916 20713449
PCNA NEIL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18032376
PCNA POLI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16763556 26903512 15342632 23248005 11724965 19208623 16357261 18931444
POLD1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
XPA CUL4A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
CAND1 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 18606781 19295130 22405651 27203177 17079684 21249194 19231300 12504026 21145461 12504025 22474075 12609982 16964240 15448697
XRCC5 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
NBN H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
H4C6 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
H4C6 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
BRCA1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12919958 12024016 17352427
ABL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23331499 12110584 20651945 29065514 22352870 16702947 25973395 27626309 21081495 27956626 20841568 14757045 19738896 15212693 28690977
ABL1 TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15448168 20841568
ABL1 DDX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17018282 17412694 11823473 17384675
ABL1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20841568 20101225 30692633
ABL1 ERCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17626041 20841568 27827925
ABL1 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9874796 20841568
ABL1 CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18083107 17389395 11094059 19534553 8632005 12531427 27292265 24632723 11075810 12036959 15592455 20841568 15951569 20808760 16151024
ABL1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19563810
PARP1 APEX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17548475 11440997 12727891 15135726 10364231 11340072 9804757
RPA1 APEX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
APEX1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18786561 19180539 9119221 19737086 16713569
TP53 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12386811 12372430 17108111 21927023 21394211
TP53 ATF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15933712 18431400 11792711 16169070 16713569
NFKB1 BAX â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 12676992 15613549 21725609 23178297 23572150 7834749
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
MAPK8 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525785 18471544 16709574
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
BRCA1 RAD50 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 SFPQ â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 SFPQ â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 RAD50 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
CDK4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9244350 16713569 17334399 20932174
RAD50 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10783165 16260778 16391231 10426999 11504724 25084169 25184681 16713569
BRCA1 RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 21908405 18285836 16713569 15485915 25310973 9738006 17525342 17525340 16843262 24085845 25184681 26387952 18369654 9811458 16818604 20351172 23416467 19442256 10196224 10910365 19452558 11739404 25252691 10764811 25659039 17965729 11689934
BRCA1 FHL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 14550570 25184681 14986435
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
DDB1 CAND1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 19748355 12504025 18805092 15688063 18851830 23453757 15537541 23535663 11961546 21463634 12504026 12609982 23535662 21863050
RBX1 CAND1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 Reactome 19748355 12504025 18805092 15688063 18851830 23453757 15537541 23535663 11961546 26632597 21463634 12504026 12609982 23535662 21863050
ESR1 CAV1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11773442 17535799 15033483 22031296 15496458
TP53 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10684646 20610713 17014845 11076533
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
RPA1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA CUL4B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
POLD1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
POLD1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA DDB1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDX17 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19995069 21182205 12738788 20348541 19718048 20663877 25604459
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
DDX5 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15298701 17369852 20022962
ERCC5 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8652557 16713569 20840796
ERCC2 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10734072 8652557 10024882 16669699
RPA1 ERCC5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17000769 9699634 7700386 15590680 9716411 17466625
ERCC6 ERCC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16916636 8652557 16713569 16246722
ERCC8 ERCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22902626 16751180 7664335 20541997 16916636 26826127 22032989
ERCC6 XAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10944529
ERCC6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16713569 10882116 19221478 18784753
RBX1 ERCC8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
ERCC8 XAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10944529
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
ESR1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18234909 11522780 9869301 10428965 12761896
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
ESR1 MACROD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17893710 18206366 19403568 15691879
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
SMARCA1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16705163 8005433 8612772 3284746 3545494
TP53 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9266967 20094059 15153330 17611664 18945670 14614455 17293853
KAT2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19680552 11804596 12068014 16537920 9891054 10490106 14614455 20589832 19788416 12660246 12501250 16959611 19407812 9744860 15965232 16678111 17977830 17189186
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
MAPK8 STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 30087586 20630875
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
NCL MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24147044 16751805 22103682 20195357
USP7 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 17936559 26460617 15916963 24462112 22056774 18566590 20816748 16402859 20713061 16943424 17380154 29236775 16082221 26238070 34799561 16845383 16474402 28406480 27452404 28196907
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19805293 22056774 17290220
MEN1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11526476 16997566 16713569
NBN RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
NBN PARP1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
NFKB1 RBX1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
SFPQ NONO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17452459 21988832 17145710 17507659 12403470 11259580 30021884 10858305 18042045 20421735 25959826
NONO TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 10858305 9756848 17481653
TP53 OGG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16293709
PARP1 XPA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
PARP1 RAD50 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
PARP1 RBBP8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
PARP1 RAD50 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
PARP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9312059 17891139 15044383 12898523 14627987 16713569 9565608
PARP1 TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 20875401 15911331 15848144 14699148 15247263
RBX1 PDCD4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16697054 17053147 17884153 18931676 19270156 19622404 19686080 19797085 19809470 19847258
POLD1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RIF1 RAD50 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
XRCC5 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
RPA1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA RBX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
VCP RBX1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
RBX1 SKP2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 TCEB3 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
RBX1 SKP2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 TCEB3 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
XRCC5 RIF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XPA RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12527904 19446504 7665601 8972858 7876167 20304803 7565690 9535929
SFPQ TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 9756848
TP53 USP7 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 16402859 15053880 16474402 11923872
USP7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 26460617 21845734 23382381 16713569 25283148 15916963 18375498 19918835 24462112 22056774 17268548 22653443 23388826 21170034 20816748 17525743 16402859 11923872 17380154 16082221 26238070 16845383 16474402 35538032 22084066
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
UVSSA USP7 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
XPA XAB2 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 7533895
ERCC6 CNN1 â—¼   KO_UP_REGULATES ✅ + 1.0 1.0 PKG 28854368
ERCC6 CDA â—¼   KO_DOWN_REGULATES ✅ - -1.04 1.03 PKG 28854368
ERCC6 NEU1 â—¼   KO_UP_REGULATES ✅ + 1.04 1.04 PKG 28854368
ERCC6 MAPK6 â—¼   KO_DOWN_REGULATES ✅ - -1.05 1.04 PKG 28854368
TP53 FLNC â—¼   KO_UP_REGULATES ✅ + 1.04 1.04 PKG 28854368
ERCC6 HMGCS1 â—¼   KO_UP_REGULATES ✅ + 1.05 1.05 PKG 28854368
ERCC6 FADS2 â—¼   KO_UP_REGULATES ✅ + 1.06 1.06 PKG 28854368
ERCC6 NUCKS1 â—¼   KO_DOWN_REGULATES ✅ - -1.08 1.07 PKG 28854368
ERCC6 PHYH â—¼   KO_DOWN_REGULATES ✅ - -1.09 1.08 PKG 28854368
XPA PDCD4 â—¼   KO_UP_REGULATES ✅ + 1.09 1.09 PKG 28854368
ERCC6 CDK4 â—¼   KO_UP_REGULATES ✅ + 1.09 1.09 PKG 28854368
ERCC6 PRSS1 â—¼   KO_UP_REGULATES ✅ + 1.09 1.09 PKG 28854368
ERCC6 HMOX1 â—¼   KO_UP_REGULATES ✅ + 1.1 1.1 PKG 28854368
TP53 FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.12 1.11 PKG 28854368
ERCC6 MTRF1L â—¼   KO_UP_REGULATES ✅ + 1.11 1.11 PKG 28854368
ERCC6 TUBAL3 â—¼   KO_UP_REGULATES ✅ + 1.14 1.14 PKG 28854368
NBN TAGLN â—¼   KO_UP_REGULATES ✅ + 1.16 1.16 PKG 28854368
ERCC6 DCD â—¼   KO_UP_REGULATES ✅ + 1.16 1.16 PKG 28854368
DCLRE1A MMADHC â—¼   KO_DOWN_REGULATES ✅ - -1.2 1.19 PKG 28854368
ERCC6 KDM4B â—¼   KO_DOWN_REGULATES ✅ - -1.22 1.21 PKG 28854368
ERCC6 ERCC6 â—¼   KO_DOWN_REGULATES ✅ - -1.24 1.23 PKG 28854368
ERCC6 LRIG1 â—¼   KO_DOWN_REGULATES ✅ - -1.26 1.25 PKG 28854368
ERCC6 LCP1 â—¼   KO_UP_REGULATES ✅ + 1.27 1.27 PKG 28854368
XPA HMGCR â—¼   KO_DOWN_REGULATES ✅ - -1.28 1.27 PKG 28854368
ERCC5 SLC16A3 â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
ERCC6 TAGLN â—¼   KO_UP_REGULATES ✅ + 1.3 1.3 PKG 28854368
ERCC6 CAVIN1 â—¼   KO_UP_REGULATES ✅ + 1.3 1.3 PKG 28854368
ERCC6 VAC14 â—¼   KO_DOWN_REGULATES ✅ - -1.34 1.33 PKG 28854368
ERCC6 CAV1 â—¼   KO_UP_REGULATES ✅ + 1.33 1.33 PKG 28854368
XPA SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.35 1.34 PKG 28854368
ERCC5 FGF2 â—¼   KO_DOWN_REGULATES ✅ - -1.36 1.35 PKG 28854368
ERCC5 HMGCR â—¼   KO_DOWN_REGULATES ✅ - -1.4 1.39 PKG 28854368
ERCC5 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
ERCC6 GSN â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
ERCC6 MACROD1 â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
TP53 BAX â—¼   KO_DOWN_REGULATES ✅ - -1.43 1.42 PKG 28854368
ERCC6 UBL5 â—¼   KO_UP_REGULATES ✅ + 1.44 1.44 PKG 28854368
ERCC6 FLNC â—¼   KO_UP_REGULATES ✅ + 1.5 1.5 PKG 28854368
ERCC6 SCD â—¼   KO_UP_REGULATES ✅ + 1.5 1.5 PKG 28854368
ERCC6 PDCD4 â—¼   KO_DOWN_REGULATES ✅ - -1.53 1.52 PKG 28854368
ERCC6 ANGEL1 â—¼   KO_DOWN_REGULATES ✅ - -1.53 1.52 PKG 28854368
ERCC6 AKR1C3 â—¼   KO_DOWN_REGULATES ✅ - -1.54 1.53 PKG 28854368
ERCC6 STMN1 â—¼   KO_DOWN_REGULATES ✅ - -1.63 1.62 PKG 28854368
ERCC5 ERCC5 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
XPA KDM4B â—¼   KO_UP_REGULATES ✅ + 1.79 1.79 PKG 28854368
NBN SPP1 â—¼   KO_UP_REGULATES ✅ + 1.86 1.86 PKG 28854368
PARP1 TAGLN â—¼   KO_DOWN_REGULATES ✅ - -2.06 2.05 PKG 28854368
ERCC6 FGF2 â—¼   KO_UP_REGULATES ✅ + 2.14 2.14 PKG 28854368
NBN BRPF1 â—¼   KO_UP_REGULATES ✅ + 2.27 2.27 PKG 28854368
XPA SLC16A3 â—¼   KO_UP_REGULATES ✅ + 2.73 2.73 PKG 28854368
ERCC6 SPP1 â—¼   KO_UP_REGULATES ✅ + 2.77 2.77 PKG 28854368
TP53 RPS27L â—¼   KO_DOWN_REGULATES ✅ - -3.35 3.34 PKG 28854368
ERCC6 ANXA1 â—¼   KO_UP_REGULATES ✅ + 3.36 3.36 PKG 28854368
NBN NBN â—¼   KO_DOWN_REGULATES ✅ - -6.31 6.3 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368