Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
TP53 ATF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ERCC8 CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CCT5 COPS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT5 COPS7B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EP300 COPS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8414198 23441852
EP300 COPS2 â—¼   ACETYLATION ✅ 2.0 0.8 intact 8414198 23441852
COPS6 ZNF24 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
CUL4B GPS1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
UQCRQ ERCC8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ERCC8 TCEA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16916636
ERCC8 XPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8999876
ERCC8 HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16916636
IQGAP1 GPS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GTF2H2 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TP53 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22103682 8291914
TP53 S100A8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SSBP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19066201
TP53 ZNF24 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CCT8 PFDN4 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
COPS4 CUL4B â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
GTF2H2 TCEA1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
COPS5 ERCC8 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
MDM2 ATF3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 34114479 31796886 20592017 15933712 29225035
POLR2A SNRNP200 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
CCT3 PFDN4 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
CCT4 PFDN4 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
CCT5 PFDN4 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
GTF2H2 POLR2A â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
EIF3L RPS10 â—¼   PHYSICAL_INTERACTION 819.0 0.81 STRING 36370105
UBXN7 CUL4A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22466964 18775313
CSN5 DNM1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31950832 21145461
EP300 CSN6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16169070 33742100
MDM2 CUL4B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 22032989
UBXN7 RBX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22537386 18775313
TCEA2 TCEA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17643375 33961781
EIF3K RPS15 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF3K RPS28 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF3L RPS15 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
COPS7B RBX1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
COPS8 RBX1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
EIF3K RPSA â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
EIF3L RPSA â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
CSN5 RBX1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19295130 18850735 30349055
DDB2 CSN8 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12732143 33961781 26496610 26186194 28514442 16260596
ERCC8 CSN8 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12732143 29531219 16751180
DDB2 PFD4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
PFD4 ERCC8 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 29531219 33961781
UBXN7 CUL4B â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22466964 31973889 18775313
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
COPS2 GPS1 â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
COPS2 RBX1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ATF3 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EIF3K RPS10 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NCL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ATF3 MDM2 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
EIF3L RPS28 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CSN5 CUL5 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30587576 31950832 21145461 11337588 31253590
CSN8 CUL5 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30587576 31253590 11337588 21145461
PEX14 DNM1L â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21525035 34079125
COPS6 DDB1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
PFDN4 TCP1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CCT3 CCT5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
COPS4 COPS5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
COPS4 DDB1 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
DDB1 CSN6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16964240 21145461 22767593 16949367 19295130
GPS1 COPS8 â—¼   COLOCALIZATION ✅ 0.85 0.85 mint 24421388
DHX9 POLR2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CCT5 CCT8 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
COPS4 COPS6 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PSMD1 VCP â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
EIF3A EIF3L â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
DDB1 CSN5 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16964240 21145461 22767593 16949367 23357576 19295130 18850735
GPS1 COPS6 â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 24421388
CUL4B DHX9 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28225217 21145461
COPS3 RBX1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
COPS4 CUL4A â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
NCL TOP1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CUL4A CSN8 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 27173435 16964240 21145461 18606781 17079684 28514442 19295130 31973889
CUL4B CSN8 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 27173435 24981860 21145461 26496610 28514442 31973889
COPS4 DDB2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COPS6 DDB2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COPS7A DDB2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COPS8 DDB2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
XPA ERCC6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 20541997 8999876
ERCC6 ERCC8 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
COPS2 DDB2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
UBXN7 VCP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
COPS5 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
COPS3 GPS1 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
DDB2 RBX1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
COPS3 DDB2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
COPS7B CUL4A â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ERCC8 CUL4A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12732143 29225035 21145461 26826127 29531219 16751180 16949367 31973889 22902626
CUL4A ERCC8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
COPS6 COPS3 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 24421388
ERCC8 CUL4B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 21145461 29531219 26496610 16949367 31973889 22902626
ERCC6 ERCC5 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 8652557 16916636 16713569 16246722
COPS7A CUL4A â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
COPS5 DDB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
COPS3 CUL4A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COPS3 CUL4B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COPS3 DDB1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COPS8 CUL4A â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CUL4B DDB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
PCNA ERCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10408173 16189514 9305916 16713569
CSN5 CUL4A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12732143 26976604 33961781 16964240 21145461 19615732 32047038 27029275 25349427 18606781 23357576 17079684 26186194 22956996 28514442 19295130 18850735 22474075
CSN6 CUL4A â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16964240 21145461 19615732 18606781 26186194 17079684 30945288 28514442 19295130 33179082 31973889 22474075
CSN5 CUL4B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 34026424 23238014 19615732 21145461 26496610 23357576 26186194 30945288 28514442 19295130 18850735 31973889
CSN6 CUL5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 21145461 19615732 11337588 31253590 19295130
CSN6 DDB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12732143 33961781 21145461 19615732 26496610 26186194 28514442 19295130 16260596
CSN6 ERCC8 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12732143 21145461 19615732 29531219 19295130
ERCC8 DDB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12732143 22232169 26826127 29531219 17392787 16751180 16949367 31970402 28416769 22902626
COPS8 CUL4B â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
COPS6 CUL4A â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS5 DDB2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS5 CUL4B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS6 CUL4B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS2 CUL4A â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
ERCC6 CUL4A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
CSN5 ERCC8 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12732143 21145461 19615732 29531219 16751180
CSN5 DDB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12732143 33961781 21145461 19615732 32985517 26496610 16260596 26186194 17079684 28514442 18850735
CSN6 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 21145461 19615732 26496610 22863883 26186194 28514442 19295130 31973889
COPS2 CUL4B â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
COPS5 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18926707 17879958
ERCC8 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ERCC6 CUL4B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
ERCC6 DDB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
RBX1 ERCC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12732143 16916636 22118460
TP53 MVP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19472297
CCT4 CCT8 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
COPS6 RBX1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CCT3 CCT4 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
EIF3A RPS10 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
DDB1 GPS1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CUL4A GPS1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
COPS5 CUL4A â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EIF3A RPS28 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
EIF3A RPSA â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
CCT4 TCP1 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
TP53 H1F0 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
ERCC6 POLR2A â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
PRPF8 SNRNP200 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
CUL4A DDB2 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
GPS1 COPS5 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 7228517 19444310
GPS1 COPS5 â—¼   COLOCALIZATION ✅ 0.93 0.93 mint 24421388
COPS4 RBX1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
COPS5 RBX1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CCT8 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
EIF3A RPS15 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CCT3 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT3 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
S100A8 S100A9 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
PCNA TOP1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
GPS1 RBX1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RPS10 RPS15 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RPS10 RPS28 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
DHX9 PCNA â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CSN8 CSN5 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 25043011 11285227 27173435 31950832 9707402 21145461 19615732 11337588 20399188 26186194 28514442 19295130 18850735 23636414
CSN8 CSN6 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 25043011 11285227 27173435 9707402 26344197 21145461 19615732 22939629 11337588 22863883 26186194 32034103 28514442 19295130
SF3B3 XAB2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
COPS7B COPS8 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL5 RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DDB1 ERCC8 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
COPS6 GPS1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
RPS28 RPSA â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
COPS7A COPS8 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RPS15 RPSA â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
COPS2 COPS8 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
COPS6 COPS8 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
PSMB5 PSMD1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
CSN6 CSN5 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 22939629 32034103 22863883 26344197 20399188 19295130 12220626 25144743 19615732 28514442 18850735 25043011 11285227 27173435 19141280 31950832 21145461 11337588 26186194 21625211
EIF3L EIF3K â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 28514442 33961781 32296183 24981860 26344197 22939629 19748344 18599441 21516116 25416956 22863883 16189514 23623729
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
PRPF8 XAB2 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS10 RPSA â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS15 RPS28 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
COPS5 COPS7A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SF3B3 SNRNP200 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
COPS3 COPS7B â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
COPS7B GPS1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3A EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PRPF8 SF3B3 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
COPS2 COPS7B â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS4 COPS7B â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS4 COPS7A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS5 COPS8 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS6 COPS7B â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2A TCEA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SNRNP200 XAB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
COPS2 COPS7A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS3 COPS7A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS3 COPS8 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS4 COPS8 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS7A GPS1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
COPS8 GPS1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CCT4 CCT8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS2 COPS5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS3 GPS1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS3 COPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS4 GPS1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS5 COPS6 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
COPS6 COPS7A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3K EIF3L â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT3 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT8 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS2 COPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS2 COPS3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS2 COPS4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS2 GPS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS3 COPS5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS3 COPS4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS4 COPS6 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS5 COPS7B â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
COPS5 GPS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT4 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
COPS4 COPS5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PRPF8 SNRNP200 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PCNA CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
ERCC5 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18079701 10408173 16713569 19279666 9305916 20713449
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
XPA CUL4A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
CUL4A COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
TP53 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12386811 12372430 17108111 21927023 21394211
TP53 ATF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15933712 18431400 11792711 16169070 16713569
DDB1 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
RBX1 COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
CUL4B COPS5 â—¼   DEMETHYLATION ✅ 9.0 1.0 Reactome 19748355 18926707 16401342 18093314 23535663 23583660 22959436 16943200 23535662
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
XPA CUL4B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
XPA DDB1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
RBX1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
XPA DDB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
EP300 HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19608861 10753971
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
ERCC6 ERCC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16916636 8652557 16713569 16246722
ERCC8 ERCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22902626 16751180 7664335 20541997 16916636 26826127 22032989
ERCC6 XAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10944529
ERCC6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16713569 10882116 19221478 18784753
RBX1 ERCC8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
ERCC8 XAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10944529
PRKCA FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12704190 21807941 24309511
PRKCA HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11438671 20166139 17924679 10739259 20068231 12773393
PRKCA IQGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 27815503 21349850 25618329 15695813 25733387 28739799 15355962 31474712
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
NCL MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24147044 16751805 22103682 20195357
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
TP53 OGG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16293709
PRKCA TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18812399 9935181 15659650 9315650 19933256 16713569 9571186 1454855
XPA RBX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
VCP RBX1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
S100A9 S100A8 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 12645005 18802069 18809714 19732719 23248262
S100A9 S100A8 â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 12645005 18802069 18809714 19732719 23248262
XPA XAB2 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 7533895
DDB2 H1F0 â—¼   KO_UP_REGULATES ✅ + 1.06 1.06 PKG 28854368
ERCC6 ERCC6 â—¼   KO_DOWN_REGULATES ✅ - -1.24 1.23 PKG 28854368
ERCC5 ERCC5 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
TP53 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -3.51 3.5 PKG 28854368
DDB2 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -5.71 5.7 PKG 28854368