Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
AGTR1 CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
AHR CBR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22531821 17569794
APBA3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
BRCA1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574597
HTR2B CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
URM1 CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1014402108 21209336
GRB2 CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
ERCC8 CBR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NFE2L2 CBR3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20806931 22001310
LRRK2 CDKL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
VCP FAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18711132 0805371105
VCP FAF2 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FAF2 VCP â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
UBA5 GABARAPL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GRB2 MYLK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ICAM5 OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TNIK MAP3K7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001376 22904686
OTUB1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19996094
TRAF6 TNIK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1001376 22904686
VCP TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
COPS5 ERCC8 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
OTUB1 TRAF6 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 20622874 34591986 19996094
RIPK4 CUL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26972000 29435596
CBR1 EGFR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31980649 20029029
LRRK2 VDAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 21370995
CBR3 CBR1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26496610
CUL1 VCP â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
CFTR FAF2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 31324722
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
AAKB1 CBR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20562859 17353931
EGFR PTPRF â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24189400 24797263 31980649
AHR ESR1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CDK7 ESR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10949034 31527615 15461668
ESR1 EGFR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11887937 17284441 20935677 28065597 16713569
CFTR VCP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
COPS5 VHL â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ESR1 SEC61B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
HLA-C GRB2 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11513144 21339333 9605119
TRAF6 MAP3K7 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18758450
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
GABARAPL2 UBA5 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
COPS5 CUL1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
FAF2 VCP â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP3K7 TRAF6 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
AHR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12612060 17392787 10620335
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
CDK7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 30257348 10949034 15461668 9528769 22879364 12118371 28423697 27748765 15059947 16076840 7491495 12093745 23850489 15528270 7838153
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR EPB41 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 2171679 1647028
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
IKBKE ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23816933 20863366 19940156
TRAF6 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12150927 12620219 14660645 15125833 16252010 17948050 18264787 18758450 18922473 19161412
TRAF6 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 19675569 17947236 19843958 10882101 19521662 11259596 17079228 28024152 31885808 19112497 22924441 10094049 27501752 18922473 11518704 11809792 16517750 19232515 10702308 16410796 14633987 19820695 22851693 10921914 18758450 12496252 12609980 21822258 12242293 25963657 24434549 27249171 22643835 21245467 17965022 26038599
MAP3K7 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
VCP NFE2L2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
POLB CBR1 â—¼   KO_DOWN_REGULATES ✅ - -1.31 1.3 PKG 28854368
EXO1 CBR1 â—¼   KO_DOWN_REGULATES ✅ - -1.38 1.37 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368