Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
LRRK1 ABL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8010101 20697350
ABL1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10601328 19564926
ABL1 NOTCH3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 EFNA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FLNC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
JUN ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9746785 15145216
ABL1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11753601 9916993
ABL1 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19231300
TP53 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
ARAF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18039929
ARAF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18039929
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
IRS1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18762365
HMGA2 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21339738
ATM HMGA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21339738
BAK1 PSEN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ERBB4 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18676864
ITPR1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907555106 19706527
MAPK1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217079 15225643
HIF1A BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12205045 20668552
NOTCH1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9881968 16990763
MAPK1 BCL2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5217079 15225643
E2F2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11559537 18319725
NFKB1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704864 11313951
BCL2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210690
MYC BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16169462 21899728
TP53 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19427386 20124456
DNMT1 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17626006 23394612
MYC BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209154
EZH2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23624935 21406404
JUN BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16229810 17434164
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
BRCA1 CYP1B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16567799
BRCA1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18025037 16331276
BRCA1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11001824 19223505
BRCA1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12700228
CASP3 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216271 12657644
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
HSPB2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18266962
CASP3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9500443
YWHAE CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11697890 8005785
CBL MET â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5215187 11894096
CBL FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CDH1 CCND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0913813107 20439707
CCND1 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
EZH2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20132185 21697275
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
NOTCH1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10933396 15107403
CD44 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12748184 16189514
BTRC CDC25A â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 14603323 5216801
MAPK14 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19289404
CDC25A MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15672448
SKP2 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16376880 5218183
FGFR3 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AKT1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
CDKN1A RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
NOTCH1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11306509 14670925
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
HNRNPK CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16360036
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
RPS6KA1 CDKN1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0805057106 19470470
CDKN1B CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
CDKN1B RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
EZH2 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18980972 21765901
RPS6KA1 CDKN1B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0805057106 19470470
MYC CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24704206 26701207
CDKN2A CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
HMGA2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20074583 18957199
EZH2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20574448
LRRK2 DDIT4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
DDIT4 HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
SP1 DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15180327 17307335
TP53 DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400 19210572
TP53 DDIT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
HBEGF EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19631971 20430953
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
SP3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20435036 20407012
MMP2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15313914
TP53 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
EMD ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0020231 15328537
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828133 24058639
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
FLNC GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
KDR GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
ANK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PRMT5 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ABI1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
DROSHA GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 RPS13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
GRB2 HNRNPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 IQGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EIF4A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ILF3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EIF4A3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HBEGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7518560 7527043
GRB2 ITPR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 CTTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 CAMK2D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PRMT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
TP53 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8200620 21821029
HNRNPK MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8349701
IQGAP1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAPK1 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
RPS6KA1 MAPK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FGF2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9490736 12750158
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK1 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16709866
MAP2K3 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8622669 7535770
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
MAPK3 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 IRS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
HGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MCL1 BMF â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 11546872 23850759
MCL1 BMF â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 11546872 23850759
MTOR AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
AKT1 MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17611497 18954143
MYC FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NOTCH1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10644343 16847353
MYC HDAC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697349
MYC GLS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23979920 19219026
MYC EZH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21941025 19197161
MYC H2BC8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12747840
E2F2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11564866 18319725
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
ATAD2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19843847
MYC EIF4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18593934
MYC EIF4G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18593934
PSEN2 PSEN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 APOE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221852 9437013
PSEN1 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22330899 22363130
SP1 PSEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10446206
RPA2 RPLP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NFKB1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9762895
MAP1LC3A SQSTM1 â—¼   COLOCALIZATION 2.0 0.8 intact 19427866 7034152
TOPBP1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17006541 5219150
TOPBP1 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17006541 5219150
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
TP53 YWHAE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18812399 8008642
TP53 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19196987 0812256106
TP53 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17916908 20536385
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
TP53 HPSE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16474844 16901744
IKBKB TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19196987 0812256106
DAXX TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 14557665 5216762
PAK4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27496712
TP53 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10969818
TP53 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18431400
TP53 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 HGF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 ABCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10783169
TP53 FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9841917
ITGA2 COL1A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219911 17485091
JUN COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8621730 12384935
SP1 COL1A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114293 11013220
COL1A2 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9685391 30632962
CTNNB1 FZD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12095419 15473860
CDK6 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
RELA CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
YWHAQ EIF4A3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
EIF4A3 EIF4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CWC22 EIF4A3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
C1QBP IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CYP1B1 HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
EIF4A2 HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
ACTB HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
FLNC HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
ACTG1 HSPB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
HSPB2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
HSPB2 AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
JUN ACTB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10840940 11082319
CTTN ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11018051 7680654
ACTB CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11018051 7680654
ITGB1 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0807543105 19168626
ERBB4 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
CRKL ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
CRKL ABI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ITGB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19168626
ACTG1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SP1 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19164283
ABI1 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7907811 20598684
ERBB2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
FLNA CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ERBB3 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRK SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CRK FLNC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
HGF GAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12766170 10871282
KDR CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12810700 12215529
NANOG KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21119109
FBXW11 KDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22711876 21900206
ITGB1 CCNE2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ITGB1 CD63 â—¼   COLOCALIZATION 2.0 0.8 intact 5218971 16917503
FLNA IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FLNA PSEN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221852 9437013
AKT1 FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15461588 17570479
FLNA IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14743216
YWHAE RICTOR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19935711 8009452
ELK1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19554388 18240315
CDH1 MMP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 17332331 17354228
CREBBP MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15894584
HIF1A NOTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NOTCH1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NOTCH1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330899 22363130
FGFR3 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
JUN AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 11192249
JUN ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21384344 16786139
JUN CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9038212
JUN GLS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28111979
JUN MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9733728 20353950
JUN PSEN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
MET FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28536399 15911745
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23457487 24025864
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
RELA IKBKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12842894 5216511
BTRC RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 9990853
NFKB1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
SP3 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12200429 20096088
CREBBP ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
CTNNB1 CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
CAMK2D EIF4B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6538646 18486612
EIF4B RPS6KA1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218723 16763566
LRRK2 RPS6KB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19302196
HIF1A HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19071119 6802010
HIF1A ITGB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 23640055
HIF1A SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19934262 15780936
CSNK2A1 HIF1A â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17382325 5219810
CDC42 RPS6KB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
CDC42 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704645 14724572
CDC42 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11438723
DROSHA SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212972 10976766
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
SP1 CDC25B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23160377 21242964
SP1 HDAC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16280357
SP1 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17889508 16452190
SP1 HPSE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11779847 23649655
SP1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15158147 19302822
ERBB3 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SP3 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11756440 18275970
CTNNB1 IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592430 12782598
IRS2 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662806 5221055
ARHGEF12 IGF1R â—¼   COLOCALIZATION 2.0 0.8 intact 11724822 5214835
IGF1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19183465 12875741
CAMK2A AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RPS6KB1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
ERBB3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17308105
NFKB1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19027835
NFKB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21790895
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
AKT3 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22505453
HBEGF FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 HNRNPL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ELK1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7914192
MAP2K1 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10716983 10997882
PDCD4 APOE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PDCD4 EIF4G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12054647
YWHAQ CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9543386 20068082
YWHAE CDC25B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12871587 5216545
YWHAE HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10737771 5212359
YWHAQ HDAC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8008084 18045992
HNRNPA1 ARHGEF12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
EIF4G1 ITPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CCND2 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CTNNB1 NANOG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
CTNNB1 BTRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15473860 10882123
CTNNB1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17306568 12782598
NANOG DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22795133
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
HNRNPA1 TRA2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
AQR WDR77 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PRMT5 YWHAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
MAPK7 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
RBL2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8253383 18319725
CAMK2D CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20668654 1000426
CAMK2D ITPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23019322
MMP2 DCN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9148753
MMP16 MMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23691193 24376839
TRA2B LUM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
YWHAQ WDR77 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
CAV2 EGFR â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CRK GRB2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
EIF4G1 RPS13 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
APC2 CTNNB1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 10980707
APC BTRC â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
GRB2 MET â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
YWHAQ CBL â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 8005785 11697890
CDKN1A CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16765349 5218735
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
FGFR1 CRK â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10464310 25241761
TGFB1 MMP2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16189514 25241761 10652271
SP3 SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15247906 11517158 10825178 16734381 9329821 12414801 12200149 23825960
CREBBP FGFR1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
ITGA2 ITGB1 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
ARAF EMD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29777862 25852190
BRCA1 KIF23 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26831064 29656893
CD44 AQR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
EGFR ACTB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
EMD HDGF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21907836 17620012
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
MYC CUL4A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 20551172
MYC FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC DNMT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
ERBB2 RPA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21555369 26496610
CUL4A NFKB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 30945288
PAK4 CDK6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EIF4A3 CWC22 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 22365833 8293266
PAK4 ACTB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19778628 29100370
LRRK2 LMNB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 23075850
ITGB1 FLNA â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5226870 17690686
SKP2 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19270695 21358672 23911321 19270694
LRRK1 LRRK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19712061 20144646
HIF1A SP1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
BMI1 ILF3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
YWHAE HDAC4 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 8005698 11504882
MET ERBB3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25326665 21918175
LRRK2 YWHAE â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
EIF4A1 RPS13 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CD44 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 15597342
EIF4B EIF4G1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
CCND2 RBL2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
RBL2 CCNE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9891079 8253383
AKT1 CDKN1A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 31575057
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CD74 CTSL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
API5 FGF2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CDKN1B CUL4A â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
ABL1 EGFR â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
BRCA1 EZH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25531315 23624935
FGF2 CD44 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 7532176 33961781
EGFR CD44 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11606076 16565089 12093135 15597342 23265944
CD44 MET â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22897854 28628118 28205554
EGFR EMD â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24797263 20937808 28065597
EP300 ILF3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20808282 33742100
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
MTOR RPS6KB2 â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 11733037
MYC ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11839798 29467282
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
CCNE1 CDK6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
GAB1 C1QBP â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10747014 16713569
HDAC2 SP3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17548428 12151407 12176973
AKT1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
DNMT3B EZH2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BAK1 TP53 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CTNNB1 IQGAP1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
DNMT1 HDAC2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
IKBKB NFKB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 11158290
LRRK1 ABL1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29513927 24947832 20697350
CBL ERBB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26716506 12574167 25081058
CDKN1B CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
GRB2 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17474147 12577067 21706016
CRK FRS2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12154000 10092678
HDAC2 HIF1A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25241761 11641274
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
CDH1 SKP2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
LRRK2 CDC42 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21048939 21454543
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
DNMT1 EZH2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
ERBB4 ERBB3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7689552 10572067 20227043 25315821
CCND1 CDKN2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CDK6 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 16160006
FGF2 FGFR3 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
EIF4A3 SNRPD1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CCND2 RBL2 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
EZR MSN â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
ABL1 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
APC CDC42 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17145773 21311754
BRCA1 FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22990118 20305393 16713569 26831064
MET CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6538879 18273061
MET CBL â—¼   UBIQUITINATION ✅ 0.86 0.86 mint 11894096 5215187
EMD ACTB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16189514 17620012 12670476 15328537
FGFR3 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9045692 26344197
ERBB4 CRK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16729043 22973453
AKT1 FAS â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25640309 31980649
ITPR1 AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24947355 18250332
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
DAXX DNMT1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
BCL2L11 BTRC â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
DCN TGFB1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
FGFR1 FRS2 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 9182757
CDC25B YWHAE â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
BCL2 ITPR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19706527 15613488
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
HBEGF CD44 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 7532176 33961781
EMD LMNB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 17620012 12670476
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
GRB2 LRRK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31980649 24947832 19380743 20697350
MYC CDK6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22094256 28628118 28205554
MYC HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17314511 20195357 22286234 30415952
MET CRK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24828152 24728074
EZH2 HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10581039 24981860 21685935 26344197
DAXX HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10669754 12140263
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FAS FASLG â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EIF4A1 EIF4A2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BRCA1 CREBBP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
MYC SKP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BTRC PDCD4 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ERBB2 ERBB4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 TOPBP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EGFR HBEGF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RELA SP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SP1 SP3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
IRS1 YWHAE â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BTRC FBXW11 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ABL1 ATM â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
AQR EIF4A3 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
BTRC NFKB1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
EP300 SP3 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
DNMT1 DNMT3B â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ABL1 ABI1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 21320496
CBL YWHAQ â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
FLNA ITGB1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CAMK2D CAMK2G â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 RBL2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 11521194
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
DTL CUL4A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21628527 17041588 23478441 31973889 23555860 16861906 29424068 30623174 31155351 33961781 30649446 21145461 16949367
LRRK1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24947832 28065597 29513927
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
SKP2 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22770219 18243116 26593157
MAPK14 TP53 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
FGF2 FGFR3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14613973 9045692 10574949
IGF1R IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7559507 8776723 10082579 7541045 8530377 33991522 8895367 12220227 15629149 8662806
GAB1 MET â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CDKN2A MYC â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HNRNPA1 HNRNPL â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CRK EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CRKL EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IKBKB RELA â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ELK1 MAPK3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CDC25B YWHAQ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRKL GAB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
RICTOR RPS6KB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
HDAC2 RELA â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BCL2 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CCND2 CDKN1B â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ABL1 GRB2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HDAC4 YWHAE â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
BTRC CTNNB1 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 10228155
FRS2 GRB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CSNK2A1 HDAC2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
BRCA1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17352427 12024016
HDAC2 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
NMI BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11916966 16713569
CCND1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17334399 16713569 9244350
FRS2 CBL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17944804 11997436 20038681
CDKN1B CCND1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 34591612
CD44 ERBB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11606076 28628118 12093135 17092940 28205554
EGFR ERBB4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25140053 23153581 25315821 16061658 10572067
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526 25754235 16729043 23397142
ERBB3 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9756944 24189400 24658140 16729043 11173924
ERBB4 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16729043 22973453 24658140 25140053
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC SKP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23277542 12769844 12963825 26038816 17157259 24259667
GAB1 CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12138161 16713569 24728074 19380743
HDAC2 DNMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23708667 17967891 21670149 10888872
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
SKP2 CCNE1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11237742 22959436 10790373
HIF1A SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 17024177 17418410 15780936
HDAC5 YWHAE â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
DNMT1 EZH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31130994 16357870 22094255 28068325 21378168
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
HDAC5 YWHAQ â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CTNNB1 PSEN1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
CDKN1A SKP2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
EGFR GAB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
BAK1 BCL2L11 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
LRRK2 MSN â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDK6 CDKN1B â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
AKT1 RICTOR â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CTNNB1 FBXW11 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DAXX TP53 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
EZH2 HDAC2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
FGFR1 FRS2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ABL1 ABI1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 5219329 17101133
ATM ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9168116 17409407 10212258 20798688 11375976 9168117
CRKL ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16443220 22286129 7493940 14604282 8978305 9820532 18835194 9710592 33961781 8524328 19823681 7926767 16955467 24412932
ABL1 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23950177 16713569 17474147 14725908 9407116 9516488 8194526 19380743 19823681 7926767 16955467
ABL1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 16273093 25402006 7678409
ABL1 CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15556646 11494134 16713569 9174058 20675402 9195915 14604282 10829062 14725908 8626543 12475393 19380743 19823681 16955467
MYC ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21400515 23029531 19602047
ABL1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26603102 25219501
APC CASP3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 10200466 17297457 9973322
RPA2 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
ATM BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 29656893 10783165 11016625 10866324 10550055 15713674 18344987 10608806 17478428
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
BCL2L11 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22492984 12242151
TP53 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 15077116
CTNNB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17404573 16288908 12782598
JUN BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14623928 17262823 19335069
BCL2L11 BCL2L2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 23430059 23850759 9430630
BCL2L11 BCL2L2 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 23430059 23850759 9430630
MAPK14 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15486195 17570479 16818494
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
JUN BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12080089 25609649 16713569
MYC BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12646176 11916966 16713569 20215511 9788437 30415952 14612409
AKT1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21242970 10542266 20085797 19074868
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
E2F2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
EZH2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19079346 20574448
CASP3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12149654
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
EGFR CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27059931 7657591 8665853 27903975 15107835 24797263 28791635 9756944 23799367 23175185 28198003 12734385 14505571 20940296 19155296 10635327 15117950 22833562 29629558 12061819 8662998 10086340 33762435 11994282 20877636 32714745 25005938 31182136 19578043 7782294 24714105 10799548 23158001 26055326 33617900 23153581 15210722 25872741 15657067 19947936 10428778 18508924 16969069 17971399 15962011 19531499 25521828 23774213 22976291 31959764 22591401 18255265 15735736 16713569 20562913 17880946 16914641 9890970 22394513 16729043 32114396 17995934 17182860 18319245 18271526 17545148 15383614 25140053 32377695 15465819 33627783 8798643 25754235 15282549 26177020 22266821 16923119 17242169 30544639 12604776 11239464 9130710 19225046 11370743 21772844 16105874 18273061 7592693 23897813 17486068 16246327 23457600 32904620 12803489 31120930 15668240 22203672 23418353 20124286 28541302 33323455 10092522 14627991 15677445 15159412 20308550 16849543 12593795 19836242 9121472 19713535 18316398 11408594
CBL MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11894096 25241761 18273061 19433454 21222362 19450681 21163258 16397241 17533376 15123609
IRS1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10854852 19546233
CBL IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18632619 17635922 10514377
SP3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22334592 20435036
NANOG CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22378194 22381696
MMP9 CD44 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16631740 11872628 1707285
MMP2 CD44 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16631740 11872628 1707285
MYC CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22002305 22911891 19738061
SP3 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10976926 12943729 12091390
SP1 CD74 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8955189 10567217 17511886
RELA CD74 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8164652
NFKB1 CD74 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8164652
TP53 CD74 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12527807 8948636 11956069
NANOG CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17761754 19139263
TP53 CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18281511 17001315 19060337
ACTB CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HIF1A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19342889 20138114 19940121
JUN CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10700231 20566634 19959471
SP3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10649433 17370299
ELK1 DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15751966 16008523
ERBB3 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21278786 24189400 27756321 18803307 17148612 25315821 22439932 10527633 23436906 23866081 10572067
EGFR MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20624308 24189400 21918175 24362532 10722725 23866081 26551075
EGFR CRK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16729043 9642287 31980649 10595738 22973453 24658140 11956190 16273093 9617486 25402006 12198159 8875975 9480911
EGFR CAV2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 15273741 25402006 16799092
EGFR ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500850 25241761 30898150 17486068 11526509 9461599 23866081 17426253 10572067 11500516 24557338 8665853 15657067 19060928 16516204 19650109 20211985 25315821 23436906 21278786 25898135 32669362 1346931 24189400 21044682 18803307 16843263 28369073 7531698 16713569 17148612 21203579 17307140 1706616 16207817 7797556 12354693 11408594
EGFR GAB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23066441 31980649 10913131 9890893 24658140 10648629 21278788 25402006 10734310 18271526 19401591 11432805
EGFR HBEGF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9135143 28988771 12725245 15358134
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
MYC EP400 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18413597 17314511 11509179 21150319 35140242 29467282 30415952 20946988
ITGB3 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
ERBB4 GRB2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MET GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11063574 15546961 9660480 19433454 21222362 7511210 8662889 11439336
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19941816
MAPK1 MARCKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9867858 30225354
MAPK1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12419216 12974390
MAPK1 BMF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22258404
MAPK1 SP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17685427
RELA MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 MAPK14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11437382 15132979 14570892
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAP2K3 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8226933
FGF2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9490736 29436393 12750158
MAPK3 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21419341
MAPK3 SP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17685427
MTOR AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 18566587 25792870 15718470 14970221 24670654 10910062 18505677 29567957 22337773 21177249 26293922 19299511 18566586 30639242 21045808 11438723 22084251 23872070 21343617 22307628
NMI MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8668343 11916966 9781816 10597290
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC ELK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC NOTCH4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CD63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC MSN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12695333 11085504
MYC AQR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC EIF4A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC EIF4B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CDC25C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840 22446629
NOTCH1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2191300 18490439 19219071
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
ELK1 PSEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12928043 12750007
EZH2 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20132185 21546904 24006445
TP53 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15383401 20332115 21478913
TP53 ABCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11483599 10792001 9865734
TP53 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8090761 10029407
TP53 NANOG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18371449 20631301 15619621
TP53 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17216187 18431400 9023107
RELA COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10201951
NFKB1 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10201951
CDK6 CCND2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 28628118 10022865 28205554 11360184 30217970 33961781 23602568 11358847 9178893
SP1 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12840223 11297539
SP1 C1QBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11278463
ACTB ANK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
EZR ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 7876308
ACTG1 ANK2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16904324 11222639 17223356
JUN EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19164283
ITGB3 CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
MET HGF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17804794 18593464 15167892 1846706 28628118 1655405 19433454 20624990 18495663 16537482 22897854 28205554 17981115 8380735
SP3 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9223667
KDR FBXW11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AKT1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16256741 10896934
HIF1A MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20631454 19285046 19950212
NOTCH1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722525 23331499 16256737
JUN NOTCH4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23917222 21679465 17220278
RELA MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303700 20352621 17498959
RELA MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19530226 20186924
FGFR1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25241761 15929978
CREBBP NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12789342 16835236
DNMT3B CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20375073 16887905 18974268
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
PAK4 CDC42 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 16189514 29734338 17353931 11756552 31478661 20936779 9822598 26598620 31871319 26344197
SP1 IRS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19875459 19755487
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
SP1 HMGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10558886 10471823 11802722
SP1 ABCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9865734 23765166
SP1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10849443 19027835
SP3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9329821 15247906 10825178
SP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632985 18850004
SP3 ITGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8887648 11238113
FGFR1 FGF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10748122 16829530 9174056 19627396 7520751 23597563 15096041 10950949 11030354 7730326 8609172 21693575 17086194 23597562 10574979 1697263 10490103 1722683 11786412 26267536 15548653 14505356 22539306 1709094 8868466 19696444 8692946 18199118 14613973
FGFR3 FRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10629055 9660748 18373495
FGFR3 FRS2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 12767520 17496910 17673906
MAP2K1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11160134
IGF1R IGF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26027733 21645859 8452530
AKT1 HNRNPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18562319
NFKB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18234965 12527911 19763573
NFKB1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303700 20352621 17498959
SP3 HMGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12799440 10471823 11802722
AKT2 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23092893 22505453
RPS6KB2 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17053147 18296647 22431522
GAB1 IRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15644415 12506011 10455108
CAMK2G HDAC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11114197
RPS6KA1 CDC25B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23708659
CSNK2A1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14675149 25862939
CTNNB1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15592430 10987283 12154096
CAMK2B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24117889
IGF2BP1 BTRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19106159 16778892
DNMT1 DNMT3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24423239 16481298 20155458
MAPK7 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11544482 16626623
MET CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11439336
ABL1 CRKL â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDC25A FBXW11 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
HDAC4 YWHAQ â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
AKT1 MTOR â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CWC22 SNRPD1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CDC25B FBXW11 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
AQR SNRPD1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
LRRK2 YWHAQ â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
BTRC CDC25B â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
EIF4A2 EIF4G1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ABL1 CBL â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
CBL MET â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
CDC42 PAK4 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 31862538
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
HIF1A HDAC4 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 15280364 19071119 21148070 30867818 16951198
CDC25C YWHAE â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
BTRC CDC25A â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MTOR AKT1 â—¼   PHOSPHORYLATION ✅ + 0.92 0.92 Signor 21592956
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
BAK1 MCL1 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
CDC42 IQGAP1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
ARAF MAP2K1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
ARAF MAP2K2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CDKN1B SKP2 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
MAP2K3 MAPK14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
FLNA ITGB3 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CTNNB1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5218183 16376880
CUL4A DTL â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
MAP1LC3A SQSTM1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ELK1 MAPK1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CCNE2 CDKN1B â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
BMF BCL2 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 17289999 16697956 11546872
CCND2 CDK6 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
APC2 CTNNB1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ABI1 ABL1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
ERBB3 GRB2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
IQGAP1 CDC42 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5221163 8798539
CDC42 IQGAP1 â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 18809683
SQSTM1 MAP1LC3A â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 19427866 7034152
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
MET GAB1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10871282 10913131 10995442 10734310 9242692
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
CAMK2A CAMK2B â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
FGF2 FGFR1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
GRB2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5220480 7642581
EGFR CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16729043 5218694
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
CCNE1 CDKN1B â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
FRS2 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 8780727 16893902 22974441 21706016 10092678 9182757 11997436 25159185 15004239 12402043 34407391
GAB1 CRKL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25241761 10871282 24728074 30480076 10753869 23397142
EIF4G1 EIF4A1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5219000 16932749
ERBB4 ERBB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10839362 30898150 21203579 25315821 24557338 8816440 10572067 16767099
RPS6KB1 MTOR â—¼   PHOSPHORYLATION ✅ - 0.96 0.96 Signor 15905173
MTOR RPS6KB1 â—¼   PHOSPHORYLATION ✅ + 0.96 0.96 Signor 12782654
CAMK2B CAMK2D â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
MAP2K1 MAPK3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
IKBKB NFKB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
CCNE1 CDKN1A â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
ABL1 ABI1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17101133 9593709 12672821 9010225 18328268 8943360 20598684 11418237
ABL1 CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9747873 11380621 15696159 8875975 9480911 21602891 18835194 18619508 12384576 8194526 11956190 19380743 24412932 9642287 17474147 8978305 12097319 17515907 33961781 12198159 7926767
CRKL CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9162067 9129019 16982329 9590251 8621483 25814554 10907644 10608804 15107835 7545163 9092574 9195915 12244174 18835194 9311917 8524328 16503409 24886428 10657627 14604282 9820532 8662998 9461587 9851874 11399323 9344843 11157475 10204582 9660791 15556646 8978305 11553620 8626543 9988765 33961781 11263968 15358160 11133830
CBL CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9129019 9416834 22974441 8621483 25814554 9178909 15581361 18835194 8943292 12393469 8524328 8683103 8662998 10962563 9461587 19380743 16289966 11792427 8626543 9988765 33961781 9617486 8626404
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
ERBB2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9710588 11173924 21278786 16713569 9756944 24189400 31980649 22973453 24658140 30898150 16273093 17875712 16729043 11606575 8665853
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
GAB1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11314042 22536782 10871282 31980649 10913131 11960376 9804835 9890893 20473329 21706016 33961781 20936779 19380743 9242692 8596638
CRK GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8810325 10962563 8662907 19380743 10970810
RICTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24036451
MTOR RICTOR â—¼   COLOCALIZATION ✅ 0.97 0.97 mint 21045808 8088164
FGFR1 FRS2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9632781 16189514 21765395 10629055 9660748 18022941 11877385 10464310 11090629
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 31862538
ERBB3 ERBB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10799311 12896906 25241761 30523157 23680147 30898150 19411071 17426253 10572067 11173924 24557338 23866081 8665853 19060928 25326665 7592681 25315821 22733765 21075308 23436906 8816440 21278786 25898135 15812817 7538656 16843263 20227043 23688700 15504738 22806884 17148612 21203579 9130710
CAMK2A CAMK2D â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
IGF1 IGF1R â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ABL1 CRK â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
CDK6 CDKN2A â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
MAPK1 RPS6KA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
EIF4A1 PDCD4 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CCND1 CDKN1A â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CWC22 EIF4A3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CCND1 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
PRMT5 WDR77 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
MTOR RPS6KB1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
EIF4A1 EIF4G1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BCL2L11 MCL1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRKL â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CBL CRK â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL5 RPS13 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL5 RPLP1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPLP1 RPS13 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BTRC CTNNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATM ABL1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ABL1 CRK â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CBL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CRKL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ATM ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 17303408 22334513 11375976 11804596 23331499 21071413 16163361 17570479 18988627 9168116 23847781 9168117 20798688 15964794 19788416 9561848 22084676 12607003 10212258 15459660 11877377 15686624 17409407
BRCA1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12919958 12024016 17352427
ABL1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12560071 20841568
ABL1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 100.0 1.0 Omnipath 8978305 9747873 9480991 19426560 17081983 23124138 16522685 16713569 20841568 18768933 8875975 25860930 21779437 19534553 16187300 17515907 21602891 16267043 20068231 10592173 17570479 8194526 7926767 11080615 25381819 12198159 9642287 15696159 18619508 18835194 11956190 22848689 11314030 9480911 19001122 19402756 20697350 12384576 24412932 7542925 11380621 12799422 19380743 12955086 17474147 17016520
ABL1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9525940 11494134 16713569 20841568 10829062 17389395 16955467 12604776 9890970 10391678 9195915 14725908 7925293 11997497 12522270 15556646 9102067 11239464 11994282 9174058 12475393 20675402 19380743 14604282 8626543 15212693 19823681
ABL1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 8978305 22581121 20841568 10837221 18768933 7493940 9710592 16955467 8524328 23331499 21199784 18794134 10592173 21051857 7926767 16443220 18835194 24165979 26500649 18809728 15459660 26192618 24412932 9053848 22286129 8083188 14604282 21435002 9820532 19823681
ABL1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19818398 18619508 10637231 20841568 14757045 15302935
ABL1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17254966 17908796 22276948 16195327
ABL1 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9826708 12766170 9391119 9242692 10506185 8547236 10069803 7687741 10490849 11741535 21777671 8906793 12475979 9444958 7513258 7961992 15475459 9252406 7838524 7731718 8662889 7708691
ABL1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21071413 23331499 10753870
ABL1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 11726515 16713569 20841568 8596638 16955467 10592173 8647802 8194526 7926767 14725908 23950177 8112292 9407116 23181695 19380743 17474147 9516488 19823681
ABL1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 24430869 15192046 33889303 16273093 16943190 14760089 29880877 15618223 33574089 8910327 12631709 25173817 25402006 20841568 33947961 34107301 34469737 19915609 32019812 2022651 34290403 33707748 15329413 7678409 9733788 8490966 28338646 3263271 15901825 2022652 10069801 7506413 24658140 8408058 34385595 31980649 1314835 7741752 18668345 28724430 12648464 25073158 26079946 34155348
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
ABL1 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20861316 17306540 20841568
ABL1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 17145710 20598684 18328268 12591740 9593709 20841568 18083107 7590237 11418237 12672821 17389395 19534553 8943360 17101133 9010225 11163214 26428302 21320496
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
APC JUN â—¼   PHYSICAL_INTERACTION 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
APC JUN â—¼   SHARES_COMPLEX 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
MYC APC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22911891 12695333
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
YWHAE ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19608861 20936779 25852190 17979178
ARAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 21988832 18039929 24746704 16189514 32296183 25852190 21779497 11909642
ARAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 18039929 8131746 8394352 24114843 15175348 15466476 94178255 7936666 7731720 7873542 7624324 8157000 8039496 8621729
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM RPA2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 29875999 15964794 11877377 17303408 9725899 16163361 14872059 23847781 9139719 10713094 9295339 20860841 16731533 12607003 22977173 7171818 15459660
ATM HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27245613 24681585 21095578 18971907 21095582 27027353 23573973 27068951 25956861 23707302 26942179
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11756551 18077418 19279141 17525332 17446169
ATM DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 23405218 17525332 25659035
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
BCL2 BAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
MCL1 BAK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 20501829 22039431 23430059 23850759
BCL2 BAK1 â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
MCL1 BAK1 â—¼   PROTEIN_INTERACTION 4.0 1.0 ACSN 20501829 22039431 23430059 23850759
MCL1 BAK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 20501829 22039431 23430059 23850759
TP53 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22983126 18519674 21233848 15033822 15489892 15105295 10741712
BCL2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 9463381 14980220 11206074 17289999 26004684 11728179 20836993 19168699
BCL2L2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17289999 18178565 25416956 10381646 15901672 32296183
MCL1 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 17145710 18040043 17097560 22516262 26004684 19148187 15077116 19968986 23680104 27818144 15901672 10579309 10837489 21613222 20836993 26186194 17289999 32296183 15637055 26045051 20023629
BCL2 BMF â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11546872 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BCL2L11 â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 10198631 11704864 15486085 15724238 17446862 22039431 23064052 23377657 23430059 23850759 8929532 9430630
BCL2 BCL2L11 â—¼   PROTEIN_INTERACTION 12.0 1.0 ACSN 10198631 11704864 15486085 15724238 17446862 22039431 23064052 23377657 23430059 23850759 8929532 9430630
BCL2 BMF â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 11546872 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
NFKB1 BCL2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11313951 11704864 21725609 23178297 23572150
BCL2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 17446862 19289794 19565474 22039431 23064052 23377657 23430059 23850759 24027568 8929532 9069260 9872359
MYC BCL2 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
BCL2 MCL1 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
NFKB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16254192 11567031 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 12032828 19233129 16022909 18761399 18987666 15934930 21224428 16453001
SP1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14660675 20435036 12032828 10542244 15713621
RELA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 19233129 16022909 18761399 18191642 21224428 16453001
MYC BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8036017 17404573 12695333 24167291 18809243 19201832 16316993 19649202
TP53 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17693666 8183578 10037739 16738310 18397889 19521340 18487508 21666495 16294215 21656028 22869582 19714248 10744634 8174112 17592775 11782367 19137013 20428827 18682598 11713302 11313951 20501806 9649502 24814047 15767042 24098340 11193470 10329733 21859835 22266868 10953306 19555669 23638218 14684736 19411072 20530667 24155778 8205530 20840522 9000137 15326476
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
MAPK3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9115213 10669763 9735392 11323415 21785723 9738012 10677502 23272207 25826088
TP53 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12667443 19555669 8205530 19007744 11313951
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
BCL2L11 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 17145710 9463381 16697956 9430630 17074758 17097560 19805519 18498746 26004684 14517273 10198631 21199865 20836993 26186194 15694340 17289999 17692808 11301022 23845444 21671007 9731710
MAPK1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9115213 10567572 12039864 10669763 15225643 11323415 21785723 9738012 11337027 10677502 23272207
BMF BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16697956 11546872
CREBBP BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9829964 10753867 17565603 15337521 10454566
MAPK14 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 29050237 16714293 19336399 11495898
AKT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MCL1 BCL2L11 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15486085 15724238 23430059 23850759
MCL1 BCL2L11 â—¼   PROTEIN_INTERACTION 4.0 1.0 ACSN 15486085 15724238 23430059 23850759
JUN BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17702754 16153157 23285061 22869147 21439021
MAPK3 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 15486195 25915848 17604722 14555991 28474232 19150432 18174237 12646560 12818176 15486085 15212693 14681225
MAPK1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15486195 17604722 14555991 28474232 19150432 12646560 16282323 12818176 17570479 15486085 15212693
AKT1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17145710 16282323 30923040
BCL2L11 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 17145710 16697956 17097560 17525735 22516262 21507240 19622586 19148187 19150432 21199865 10837489 21613222 20836993 26859456 26186194 15694340 17389404 15989957 27013495 20074640 23245996 26045051 16213503 20085765 20159608 9731710 15014070
BCL2L11 BCL2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 9430630 16697956 15694340 17289999 21199865 9731710 32296183
BMF BCL2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25416956 32296183 11546872
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
BRCA1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9926942 11394910 10196224 18025037 21245169 16735508 12647291
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
BRCA1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11877377 21060331 19793801 21337561 15459660 20029420
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
MAPK14 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14970175 33176141 29414778
CASP3 EIF4G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10611228 9819442
CASP3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25241761 9660939 10022118 9799125
CASP3 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15014070 15713684 15637055
CASP3 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9367996 11741536
CASP3 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11274152 10672017
CASP3 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10069390 16189514
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CASP3 PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10069390 9219695 9990034
CRK CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL CBL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
GRB2 CBL â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 31980649 8649804 8995445 25036637 23799367 11997436 8943292 9242692 10570290 8662998 11399323 10086340 7642581 9108392 20936779 11133830 8626404 17094785 8063801 9129019 8900205 15210722 8621483 25872741 25814554 9178909 16906159 8950973 17971399 10025673 9295052 19380743 9716598 16713569 11964172 9234717 8083187 7537740 8824292 9259313 9311917 7791764 17072306 14725908 33627783 9461587 9434624 9851874 8695851 12839496 17944804 11792427 10204582 8621719 11823423 9541596 33961781 169092 11263968 98621719 28514442 18273061 7592693 9174058 21706016 8995358 9872323 9233773 9367879 7544353 12941616 10829062 20124286 917890 15677445 9092538 10521482 8647120 19836242
CRKL CBL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
CRKL CBL â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
ABI1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17395426 18594017
CRK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 8683103 16289966 8626543 8621483 9617486 16713569 9416834 8524328 10962563 8626404 9367879 8662998 12393469 11792427 15581361 9013636 15581362 9178909 9988765 18835194 8943292 20697350 9129019 19380743 25814554 9461587
FRS2 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20038681 11997436
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16397241 15123609 23331499 25241761 21222362 11894096 18672314 21163258 19450681 18273061 35309168 17533376 19433454 17635922 10514377
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
HIF1A CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23455892 20360945 20179204 15991006
RELA CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17673602 18226221 10464245 18566231 19800042 18174238 15755876 18341653 11861406 20103608 12894581 17098279 22306268 20922712 16998474 10409765 19766095 15756023 21056029 22835384 17407600 15870875 18184402 17944672 15856023 20538607 19263436 16453001
NFKB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 10464245 18566231 18341653 11861406 20103608 12894581 17098279 22306268 10409765 19766095 15756023 17407600 18184402 17944672 17008396 15856023 20538607 19263436 16453001
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
JUN CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16393119 21135252 8917510 17166846 19622016 11402335 20220142 22853846 17670745 10567390 17496887 19499154 9878062 21474819 17278098 15282324 15467760 15994313 14672732 15574422 22550166 10066798 17637753 20482821 15574764 11745411 11410592 18084253 20037604 12794082 10790372 16860316 24190040 17501623 17477349 19435822 10500157 11432833
TP53 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 24189068 8702807 10669755 22270849 12808109 17942917 19086036 20731879 16061648 20554748 24460719 11798189 10082575 15205322 18769160 19800042
CTNNB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16628468 10318916 12095419 15111320 15735151 18679417 17360646 12782598 10201372 14557550 19778454 20300972 19662654 12589056 11943708 10915780 17693601 15592430 17109766
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CDKN1B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 9106657 10908655 17254966 25416956 7478582
HDAC2 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799 15713663
CDKN1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 26203195 23443559 17145710 25416956 7478582 9837900 21988832 21516116 7777546 15232106 16082198 27107012 15695403 8657154 8242751 23007395 9106657 12383116 17556661 8756624 8662825 31515488
CDC25A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 18786381 17660363 15279786
CTNNB1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 19751508 10318916 7542250 11967263 22290435 11836555 19623618 12663502 23343194 11955436 22270359 22761862 16039586 15810077 10201372 19020303 17143292 12051714 17208333 8666229 18974774 16940750 14712077 17666529 21285352 19619488 15377999
JUN CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CCND1 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16600870 10498883 10385618 9736735 12006580
SP1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11316768 15111490 21193408 12972613 16943418 18372343 18596044 10976926 12091390 12943729
CTNNB1 CD44 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18483247 12782598 17724465 10027409
CAMK2A CD44 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19582779 9580567 1281449 12032545 16785995 22865879 11463356
COL1A2 CD44 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1730778
SKP2 CDC25A â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
MYC CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8994810 10205150 11154267 9371770 14519204 15677471 17671423
BTRC CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19847258 14603323 15340381 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
RPS6KA1 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23708659
MYC CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CDC25A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 17303408 18073536 1075565 17568790 23429262 18786381 17660363 15279786
CDC25A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 7575488 18590585 8617791 17303408 18073536 1075565 17568790 18786381 17660363 15279786
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
SP3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 10649433 12434298 18850004 7499379 10625687 11064455 23401853 16103879 19584258 12151347 20301197 19197985 15790310 12773551 8995437 10485470 23676218 12379120 18628250 16810128 16533812 23066038 9819384 10321829
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
DNMT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21229291 21572997 19056828 16276353 9588214 21868513 23658227
JUN CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11136975 12717415 21278055 10506225 19628677 12054510 18094076 10072388 18210215 10733944
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
SKP2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 32035614 25241761 23261596 17679094 15998794 17477906 19686743 16376880 15980415 18794347 13678583
AKT3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12851486 15023346 19216069 17680028 11756412 16680151 20214616 11463845 23109003 20452955 9829964 20398329 17646672 10217147
AKT2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 21933447 16982699 20452955 9829964 20398329 17646672 10217147
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
AKT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11756412 11923280 16697215 20452955 27603133 20398329 18372248 15001356 15808505 10217147 19440234 20138985 12431783 10753973 17855660 19216069 28358423 20214616 11463845 9829964 17570479 17646672 16680151 11231573 15169778 12851486 31575057 25241761 23109003 21933447 10949026 16775416 23886938 26436589 16288292 11715018 16055744 18636226 15023346 9812896 12042314 17680028 24848107 16982699 11779850 10722653 20832730 18570873 20307683 34069970 17052453 15798220
MAPK14 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23745637 12058028
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
HDAC4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18632985 18850004
EP400 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17671089 20548951
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 23443559 31831640 21988832 9472014 17293600 11438644 9380407 12839982 16765349 9632134 25241761 8891332 9660939 8242751 9218599 11477082 8756624 8662825 8637717 9716181 13678583
TP53 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15145945 15988033 19235838 10516009 21478095 14984207 19427386
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
MAPK3 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 33574916 10781063 30976006 10375532 17409098 17209046 34407842 11425869 27140628 10931950 17254967 12700233 19584057 16160006 11726503 11889117 26528715 10831586 12907657 16880511 12140288 19473963 15735731 12529437 25132260 17254966 21715330
AKT2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12244303 18593906
CCNE1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
MAPK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12042314 9192873 10831586 10931950 12700233 15212693 15735731
CDK6 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16160006 25241761 18615582 16782892 21439954 11360184
TP53 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21340684 20066118 20457558 20182602 6396087
YWHAE CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14504289 16189514 12042314
CCNE2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
SKP2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 26450989 20160477 12820959 18805092 16209941 24085301 11565034 15071497 18239684 22959436 17409098 22524983 15147722 12529174 23910095 15998794 16189514 22310285 35247157 12813041 21503567 20663873 22632967 10559916 11516665 11463388 12140288 15688063 15469821 20160482 15735731 15355997 15340381 12042314 15075339 21237244 19686743 32265224
YWHAQ CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 14504289 12042314 18281517 16713569 17470459
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
CDKN1B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25910212 16189514
CDKN1B CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
MYC CDKN2A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
MYC CDKN2A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11274345 11283613 11283614 11704864 15199070 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364 9694806
BMI1 CDKN2A â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 15640618 17936558 20818389 21383063 21678481 21685941 22796940
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
MYC CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15361884 11593429 11507042 20023701 23342141 16537449 23277542 10914736 9212167 12835716 24177224 11062467 15199070 18762810 19786833 20551174 11360201 23722468
SP1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10649433 22025288 15067344 17370299 21830402 17225865 12134028 19115249 16239970
EZH2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19954516 21572997 23289480 23826727
DNMT3B CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23397112 18006804 22461910 17149367 21757290
E2F2 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 11883935
IKBKB CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21619050 20152798 29292732
MYC CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15361884 9308237 10373560 17936558 12209154 12738781 17873522 11283613 21406394 9312026 15095404 17558397 20551172 19901969 19815509 10504341
BMI1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21383063 9308237 21678481 17936558 22796940 20818389 11283613 15640618 19404261 21685941
CDKN2A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17881001 26186194 23602568 9751050 11739795 11556834 9380698 15232106 16713569 17955473 10491434 16915296 17909018
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CUL4A DDIT4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
HIF1A DDIT4 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A DDIT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 17307335 20176937
RPA2 DTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
DTL CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21145461 19231300 16949367
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
NFKB1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14678988 18367518 12469217 17881446
TP53 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20190820 18359760 9664135 10029407 8152794 11713584 8887630 9285564 19597475 11546792 1586628 18604200 18391986
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
CAMK2G EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 3138233 10347170 16799092 1309762 7805884 7505275 92065884 15302935
CDH1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17548604 10969083 15662113 31980649 14681060 25241761 24189400 25468996 24658140 25402006
CAMK2A EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17389395 17081983 3138233 20166139 10347170 15901825 16799092 18691976 8226933 20068231 1309762 7805884 92065884 1956339 7505275 18669648 15302935
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
DCN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12105206 23350913 9988678 12105207
MAPK3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 1651322 17081983 3138233 15901825 16785992 1939237 91332050 27531070 17570479 2543683 2115882 34086370 17192257 1651323 15302935
MAPK14 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15187187 18039929 19138820 7535770 12738796 17139251 16932740 23397142 16785992 11274345
TGFB1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20953304 32103204 19132220 28943431
HBEGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22529914 12097488 23331499 28943431 30071291 10209155 9135143 23888518 14967450 28988771 29274275 19531065 12621152 12725245
EGFR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 19901323 15231819 16497976 25402006 17389395 20068231 23066441 11432805 9658397 19509291 18669648 10978177 10753869 10734310 11896055 18271526 24658140 10648629 11779868 31980649 15212693 9890893 17016520
EGFR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19104148 27401557 15371335 16099633 22558232 30747223 12040186 26509276 24816560 12740122 25500543 17318191 19568798 21423209 14585353 34227224 23640056 17496910 17052462 24240237 25164010 14517306 21903109 22200182 16952352 20858269 28035485 9233779
EGFR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 23397142 18271526 24658140 25402006 16729043
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1382070 31980649 24658140 12560083 9230083 15212693 10377409 15647376
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 52.0 1.0 Omnipath 10595738 9480991 16273093 9617486 25402006 17399949 8662907 8875975 21602891 20068231 8194526 12198159 9642287 11956190 24658140 26656091 9480911 31980649 15212693 26473374 16729043 17016520
EGFR LRRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24947832 22337768
EGFR MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12556561 15531749
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 FRS2 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 KDR â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 KDR â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
JUN GRB2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 FRS2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
GRB2 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 FRS2 â—¼   DOWN_REGULATES ✅ - 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
MET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9660480 15546961 22128289 12475979 11063574 7511210 11439336 8662889
ERBB4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 24658140 16829981 16729043 12731860 25140053
ERBB3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9756944 24189400 11173924 24658140 14967450 16729043
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
KDR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9405464 16966330 10319320
FRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8780727 9182757 12974390 11997436 16189514 12402043
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
MAPK3 HNRNPK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11259409 16564677 11231586
HNRNPK TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18472002 16360036 23092970
IQGAP1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15655247 11319218 8226933 1330321 1497021909368021 16135787 17563371 7992057 8248196
IQGAP1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11319218 8226933 1330321 16135787 17563371 7992057 8248196
IQGAP1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 17145710 9182573 8798539 12377780 9199170 8670801 17563371 8702968 12745076 15695813 21876773 8756646 12900413 18809683
IQGAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12446675 9694656 11734550 12377780 16622255 10473551
IQGAP1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7731720 14970219 18567582 16135787 17563371
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
ELK1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 8386592 11145955 7588619 7889942
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
MAPK1 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 17145710 9130707 20506250 15547943 12551925 19690332 9763608 12697810 8007980 16291755 11279280 16393692 17255949 8208531 15014501 10637505 15187187 8586671 19541618 11145955 19565474 11309409 8887554 17052211 9501095 18334532 15782123 8548291 9927426 21655091 7889942 8262053 15655247 8386592 10716983 12665513 15967991 10644696 8477450 12947314 11274345
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17081983 32814053 20385094 11532940 7601337 23331499 15342917 8939914 21071413 23047924 20068231 11335727 9687510 12618428 18988627 18669648 23519423 23109003 18691976 12594221 9915826 17906627 8202512 9430688 19651622 12832467 11500364 14966081 29997244 25730857 8387505 10411321 18212344
MAPK1 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12223490 18220336 15241487 25324174 16543145 18676833
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 12054624 15547943 20080742 14967450 12040186 15173823 12697810 11940578 7545671 16227978 21035469 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 19085255 11279232 9271440 18039929 18775330 11705993 10601235 12792650 11431469
MAPK1 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10537323 21079800 17570479 22514278 20444238
MAPK1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19917258 17855441 21419341 21900237
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 15001544 17081983 18949383 16123357 27014871 16914728 17360977 16099428 30401435 16131083 17640984 12510059 15613682 21850561 14579029 20594869 8626671 9395471 19651622 15576463 22289259 14769130 16020478 17242212
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12008033 26538579 15379552 10593929
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAP2K3 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 12589052 11279118 17081983 20213747 7914033 18767875 17322306 23602568 8622669 18855897 19690332 23904011 9162092 11426938 15592455 18083107 7997261 12384504 15735649 18291705 23331499 17389395 7535770 19534553 7839144 21071413 16083285 21614932 20068231 12738796 16189514 17255949 18669648 16153436 14970210 26186194 16407200 11242034 18691976 18088087 11304531 15972258 10781613 17192257 18586681 10734320 19651622 7592586 16157584 19369195 9582275 15674326 9528766 7693711 9841871 12758252 11309380 7750576 15212693 15659558 11274345 15735648
MAPK14 CDC25B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19638579 12400006 17570479 16851915 11333986 15629715
MAPK14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15187187 21675959 18039929 12738796 23397142 11238443 11274345 12697810
MAPK14 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15187187 18039929 12738796 11274345 12697810
MAPK14 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 21675959 26247731 20213747 17535811 20506250 15657900 9315650 15642743 19413330 11283254 22975381 10581258 16083285 1088347 21614932 16393692 10884347 21050851 16552184 10747897 15187187 17906639 25789565 15140942 11258706 24818748 19436832 10781582 10212189 17172861 10348343 11078726 11274345
MAPK14 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21902831 30022044 17570479 27494834 28067271
MAPK14 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15187187 18039929 18411303 12738796 20626350 11274345
MAPK14 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 15150265 10744722 9836640 9543386 12941695 20068231 9278512 10681541 16189514 15791647 11551930 9278511 11333986 15629715 10557092
MAPK14 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12842894 15128824 15485852 10521409 15489227 15849198 15212693 12767944
MAPK14 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17486076 27843138
MAPK14 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 9130707 20506250 8622669 23331499 21614932 16393692 20126313 17570479 18988627 23322625 10637505 15187187 26516701 15140942 11145955 11309409 8887554 9235954 8548291 15782123 20727996 8262053 19436832 12665513 12887893 11701445 12947314 15212693 11274345
MAPK14 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15649893 14580335 16648474 15371334 17072322 10747897 17255949 11274345 12697810
MAPK14 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12475989 17689131 17570479 25483191
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
ELK1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 8386592 11145955 7588619 7889942
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR3 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
MAP2K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 9694850 17081983 11319218 18799465 17389395 9447970 15342917 8226933 15851026 12270934 12644307 11242034 1381507 17906627 9677429 11986622 8376945 7992057 11948414 7687743 9731057 19197339 11704645 7565670 12750173 12932319 8626767 23331499 12048245 7559390 17272394 15811950 26987942 19494114 18669648 18691976 17192257 8388392 7898932 16464493 19369195 12920017 15466214 19690332 11134045 19534553 10995751 7867743 8223433 8248196 10567369 19933846 17563371 1518847 11730323 18983981 16186792 16135787 15951569 19058874 15212693 10748187 9560161 9925641 9733512 18083107 11104681 9006895 17569879 21071413 7731720 1330321 93330262 19541618 15466476 12925710 11971971 11136732 11118451 10746662
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 32205409 20150555 21983342 11904305 14593115 18199680 8226933 14744793 16079281 19318349 20882567 22266860 28574228 21097497 8388392 32615164 16377629 19245816 18775330 9604935 15212693
MAPK3 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 9130707 20506250 15547943 20371703 7618106 7601337 12697810 12473660 23331499 8007980 16291755 16393692 16998585 18988627 17255949 8208531 15014501 15187187 8586671 19541618 11145955 25241761 19565474 11309409 8887554 17052211 15277685 18334532 15782123 8548291 14499342 9927426 7889942 8262053 8386592 10716983 12665513 15967991 8477450 12947314 15212693 11274345
MAPK3 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 15547943 20080742 14967450 12040186 15173823 12697810 11940578 16227978 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 11279232 9271440 18039929 18775330 10601235 12792650 11431469
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23331499 15342917 18039929 12832467 23109003 8387505 14966081 9915826 21071413 17906627 9430688 11335727 18988627 11532940 10411321
MAPK3 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15241487 21507240 25324174 16543145 18676833
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MAPK3 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12008033 15379552
MAPK3 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10537323 17081983 18088087 15144186 21079800 16964243 20444238
MCL1 IKBKB â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
RELA MCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22496479 19303700 24529193 18761050 18223231
ELK1 MCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21258408 23158473 21362474 9880563 15542842
SP1 MCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22406829 18599869 17198743 22734486 18208354 23877711
BMF MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16697956 11546872
TP53 MCL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11160159 19808698 11832478 18208354
MTOR RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR EIF4B â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR EIF4B â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 12150925 12408816 12844354 12867079 12906785 15755954 15905173 16286006 16469695 16679021 17368478 17680028 18391071 18492954 19022819 19339977 19568798 19597330 19864431 20647036 21157483 21177869 21233202 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
SQSTM1 MTOR â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15340068 16252010 20531300 21981924 25002027 26587781 28574505
MTOR MMP9 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MTOR MMP2 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18492954 19022819 19568798 19864431 19930715 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 27328425 27510662 27572739 28216025
MTOR MYC â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
MTOR RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 25062042 17510057 17081983 15208671 22873724 16922504 23077579 12087098 28270148 16286006 15896331 25356520 17664694 21790669 26919095 26313911 21561857 10567431 16099428 21977024 14679009 11940578 15899889 15388791 12829246 21980324 22751450 12604610 9465032 20068231 10601311 28122439 19302577 21602892 15718470 15631631 23273915 18669648 21307646 10579915 23261705 20169205 25936802 25486097 24411482 12586835 23342114 15809305 14560963 22472346 11279232 15760907 9271440 27856330 12370290 23486913 12782654 11914378 24795562 19877273 28242756 11500364 26698305 14993219 20459645 23029019 16964243 15212693 25505994
MTOR AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 17517883 18372248 19203586 27418134 17277771 15718470 26491696
MTOR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 22570710 15952059 19561084 21282364 25973388 14769130 11287630 9335553 17698034 20863384
MTOR RPS6KB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12150925 11914378 17510057 21157483 17680028 19864431 12087098 15755954 16286006 9465032 15060135 11733037 14560963 12408816 20932932 23486913 19568798
MTOR AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17517883 18372248 19203586 17277771 15718470
MTOR AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 24670654 16697215 11438723 21592956 20398329 17461779 18372248 21177249 21045808 20338997 15808505 16221682 20138985 20489726 15899889 20214616 8978681 21474067 14970221 19203586 17660512 15718470 19568798 20333297 23006971 15169778 25241761 18566586 19720745 17517883 18925875 22084251 10949026 14761976 11715018 19143635 17277771 18636226 10910062 15047712 9812896 18505677 21343617 19844585 17680028 19151919 18566587 9736715 23872070 10722653 20832730 18570873 17013611 17052453 12408816 15364915 11274345
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC MMP9 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC TGFB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC GLS â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 11283614 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
MYC CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9632747 19176757 23364919 10523846
MYC FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14563113 20101459 20155283 12655294 14519204 10734130 11050389 15302589
MYC CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18802399 20607601 14519204 22583478 9188852 11983916 11509615
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC HNRNPA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12747840 20010808 12695333
MYC IGF2BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21779431 18414489 21252116
MYC ITGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11381265 16878156 12695333
MYC SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24259667 12963825 12769844 23792459 21245140 24177224 23277542
MYC PSEN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12695333 18414489
MYC CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20682794 22395148 12835716
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
SKP2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17145710 24259667 12963825 12769844 17157259 23277542 20852628 16376880 35260179 26038816
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MAPK7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22046506 9461566
MYC NMI â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 17145710 10597290 8668343 17093053 9781816 11916966
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
NOTCH1 PSEN1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
PSEN1 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
PSEN1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11518718
PSEN1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10593990 10077672 16713569 10206645 12374741
PSEN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17145710 11168528 16126725 11226248 2195779 11161700 12070348 9738936 10037471 18070361 9632714 10092585 9223106 12297048 16306047 10341227 9852041
PSEN1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10635315 11226248 16126725 11953314
RPA2 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA2 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA2 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
SQSTM1 FAS â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 FASLG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 DAXX â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SP1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9762895 12736330 17012241
MAP1LC3A SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 20061800 23022382 23459205 35044719 22963397 36036324 31053714 21045561 25921531 19250911 17580304 21628531 20204693 28740232 23640897 25686248 24100292 26075355 20562859 22658522 25984893 21460636 16286508 19427866 32296183 23989536 19021777 26268733 22714671 24998849 18653543 31366950 33436498 16169070 23239879 26754771
AKT1 TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24081328 17913746 33556369 17006541
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
NFKB1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10348347 11032029 8051093 12145335 20097177
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 CDC25B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23160377 21242964 20176018
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
TP53 CDC25C â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11396965 16582636 16807237 15574328 19861536 11972334
TP53 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 1346476 18234965 8554604 8898977 10745175 19714248 9988237 10029407 11096091 11172607 11920581 17952118 8679460 9112432 11350951 8502478 11483599 7949467
TP53 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15131018 11001824 12089352 20633551 24205274 17097318 10023442 17600529 17014845 8710868 12444079 16181796 22033326
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
TP53 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18980971 22451655 23048035 10029407 9343394 19853299 11792711 19939245 17088079 17258390
TP53 IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12631625 18281476 18174288 21460853
TP53 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22466965 18811981 16557594 24492005
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10101800 12788915 15580300 16317104 16322229 14719118 16557594 20797428 11103825 19615968 7539102 12447615 12944915 12963547 11313989 16951143 9841917
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17196791 9889415 20393600 9841917
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
DAXX TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12954772 21482821 21134643 16845383 25241761 15364927 16713569 12482984 15339933 23038753
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
TP53 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18431400 29302370 16753148 16713569 10853038
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
SP1 COL1A2 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
SP3 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9242631 9278495 10771485 11511308
SP1 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20429888 8182090 12760745 16319104 8524247 11348466 16564026 9242631 11114293 22049076 9278495 9143363 10771485 11278686 9882423
COL1A2 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1693626
COL1A2 ITGA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 2156854 17485091
NANOG CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22378194 17761754 19139263
CCND2 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10477583 17517622 16713569
CDK6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17208333
CDK6 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10498883 10385618 9736735 11157749 12006580
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
MET CRKL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
CRK CRKL â—¼   PHYSICAL_INTERACTION 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
HGF CRKL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
CRKL KDR â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRK CRKL â—¼   SHARES_COMPLEX 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL KDR â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRK CRKL â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
GAB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
CRKL GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
SP1 EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21628504 19164283
AKT2 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14504278 15531580 10970850 11387207 15843435
HGF CRK â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
CRK KDR â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
CRK KDR â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15308668 15501236 15520864 15573129 16000375 16002046 16076871 16530705 16572188 17086423 17883421 18835194 19414323 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 8837607 9157999 9570538 9753319
IRS1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9837978 8810325 8621590
IGF1R CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 12198159 9642287 9480991 9480911 20068231 11956190 8194526 8875975 15522217 17016520
CRK GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24728074 20619534 12138161 19380743 11146548 10592173 19350053 16713569 10618718
HGF MET â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11290563 12649206 15059978 16212809 17145802 18633355 19631971 20303741 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
HGF MET â—¼   PROTEIN_INTERACTION 16.0 1.0 ACSN 11290563 12649206 15059978 16212809 17145802 18633355 19631971 20303741 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
FGF2 HGF â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 9242465
SP1 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9223667 17967179 12482909
HGF MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 17145710 22897854 15167892 1655405 20624990 19433454 23331499 17804794 1846706 28475121 22001117 16537482 15218027 27147579 24362531 17667909 16397249 20178463 17981115 28534512 8380735 18495663 14685170
SP3 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15111490 16678129 18006642 9668119 16574784
SP1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19888537 14684628 15111490 12560084 19469899 21980525 16678129 18006642 9079666 12067897 21430706 16574784
RPS6KA1 FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15024089 12198493
AKT1 RICTOR â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 RICTOR â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RPS6KB1 RICTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 17053147 25049885 19339977 16286006 25596749 20647036 20418915 11108711 22484804 28700668 21487027 28315487 18423201 19935711 23639840 23615631 21233202 23544169 25241761 19720745 12713446 28342808 15809305 21438886 15905173 22193713 20832730 19995915 17052453
AKT1 RICTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 21177249 20338997 19402821 15808505 20138985 21339740 16603397 20214616 21474067 16919458 15718470 19568798 17545609 15169778 18566586 25241761 19720745 18925875 22990118 10949026 11715018 19143635 18636226 18411301 9812896 21343617 17680028 19151919 18566587 10722653 20832730 18570873 17052453 12408816 11274345
AKT1 MMP9 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 17409395 17680028 18471976 19440036 19930715 19945467 20214616 20398329 20609352 21084277 22131018 23572150 23589069 24030100 25136802 26597054 27328425 27510662 27572739 29556339
SP1 MMP9 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
NFKB1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 17922642 15605368 14755547 20332461 18357389 17186550 11060311 18566231 9679762 16687076 17121934 18843978 21963718 18056465 20103608 17174275 15536164 19303700 17158602 7860222 19539355 9500201 19783786 18567920 15175338 17498959 10359016 18801463 19454280 19662350 12193473 16014933
JUN MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 16798740 16554298 11774399 15949416 11429784 15777790 16014933 10935492 11326313 18809380 21474819 21963718 19455716 9136992 17572495 23176293 15708369
RELA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 23423566 17922642 15605368 14755547 20332461 18357389 21502320 17186550 11060311 18566231 9679762 16554298 16687076 17121934 15086314 18843978 21963718 18056465 20103608 21238464 17174275 15536164 18028425 17158602 17590163 19303700 7860222 19539355 9500201 22587999 19783786 18567920 15175338 17498959 19616091 10359016 18801463 19454280 24755270 19662350 12193473 16014933
SP1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8226872 24755270 18028425 9514098 9520415 23799155 20529870 21840940 7860222 17049831 21963718 18357389 9150367 11060311 19616522 11830485 9748266 20638438
CTNNB1 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
MMP9 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10652271 21900405 25241761
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
MMP2 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10652271 25241761 16189514 21900405
NOTCH1 PSEN2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
PSEN2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
HDAC2 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC2 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
CSNK2A1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 19007248 16565220 20166139 17081983 20230923 25609639 19413330 19415658 20388487 20068231 18452278 18669648 18691976 17287340 12176973 19651622 12082111 19691289 24526703 18510355 18212344
HDAC2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15169839 17615296 25241761 22796940 20818389 21685935 15388328 20519943 12508111 11309385 17018611 22514743 19597490 14673164
JUN IRS2 â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
JUN IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15187114 15270850 14688340 25567680 11279072
JUN IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8206951 19920132 19103645 8439327
JUN DCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 7499226 8798756 8940199
JUN FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9456251 10913304 10559225 11281649 11551904 23485603 23331079
JUN FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18196534 9873041 9660938 14563113 9710625 11003676 19670268 10811113 9468493 15160330 15546613 12618758 11397794 10744679
JUN ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 17283040 10369069 17452336 18213731 12907627 14612525 23678002
JUN MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19268464 15212943 14767528 19940138 11414701 15777790 20353950 17116726 16000878
JUN HBEGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12791271 7649477 15761212 9111309
JUN FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733515 12963547 10903433 19670268
CSNK2A1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 25609649 1846781 11948398 15378002 12531896 19413330 8654373 15302935 11075956 12628923 11896587 1516134 8464713 11971971 1651323 8137421 9685505 91332050
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
DAXX FASLG â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FAS â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FASLG â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FAS â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FASLG â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
DAXX FAS â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
CSNK2A1 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21474068
FAS DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 15725726 9743501 25241761 11483955 11773067 11003656 14637155 11193028 11495919 9215629
FASLG FAS â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22075988 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FASLG FAS â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22075988 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
NFKB1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14563113 12655294 15160330 16770006 10671224
SP1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10075666 20617570 11254710 11053446 14563113 10754388 18293083 15659839 11970950 12655294 17192273 11745351 15173177 15004200 10671224
FASLG FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 17145710 8521815 9126929 1375228 1713127 14965271 21803845 9039262 11239407 25241761 9228058 15659383 12753742 7505205 12887920 15725726
SP1 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10022897 9261184 22084312 9300785 10871852
NFKB1 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11473033 16317104 10022897 16784892 7528667 19628709 9733827 10871852
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RELA FBXW11 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10321728 9990852 10066435 9859996 10514424 10230406
RELA BTRC â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
IKBKB RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
SP1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7636984 8450395 9151857 20538607 11964305
RELA IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 12820969 14688340 20221401 11058167 10657616 10940886 19122653 18690006 11792125 19624579 17982049 9464836 17924060 7565674 14976188 15251981 12077291 17579043 24012417 19299558 16166378 12517966 17635610 24184907 15270850 20876114 9808189
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18234965 21054339 19763573 12527911 22927901 10026303
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
IKBKB RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 135.0 1.0 Omnipath 15280197 17785205 27329558 22110409 22753932 22205033 21765477 15611068 18519641 15858576 25241761 33579825 23536830 28122346 19393267 34556881 24442433 14560022 15192014 21242976 16840782 19609947 33789981 10521409 26826124 21492457 19110719 23303310 16105840 22212641 26587973 34219129 15210811 16046471 11359840 27626700 15128824 28416608 17178723 21674813 17362989 28737909 19377466 15980040 16407239 15849198 20507904 26082493 15557193 34082140 21798539 26267322 29363544 12767944 20224721 26307684 12842894 17108032 26170389 24336331 27315556 31980577 11259436 34380537 20872791 21674474 15465828 15994321 17548605 26603838 16148147 25136068 33914760 26569329 22234699 17012367 14636585 22039465 32123095 15212693 27466442 33883226 15611276 22081069 19197368 17070014 20051109 26693062 14963024 33971703 28381553 33459422 27244888 18544167 18922932 20188669 15485852 20696864 22689577 17982102 20410276 15489227
RELA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12055073 7933095 10671503 20861353
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
CDH1 CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
EZH2 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18377425 22130667 21685935 21770894
EZH2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 20519943 12508111 11309385 17018611 22514743 19597490 20574448 14673164
CSNK2A1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10837139 11348595 20976471 17928543 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 10671552 16707567
MET CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17496910 17336101 22558232 16909210 12040186 19568798 14585353
CDH1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 91.0 1.0 Omnipath 17145710 7542250 11348595 9512503 10652321 19016843 16909210 9233779 17220478 16219695 27177845 25344754 11245482 22752307 16983094 16212417 16574648 18593713 9535896 9819408 12830000 10772923 11801604 23180380 8227214 16546130 10085258 22056988 9700170 12640114 24424122 10381631 17087658 24798214 11226248 12875984 9405455 11712088 12061792 17909039 22158051 11960376 14706341 11254878 15023525 12169098 21255999 16125672 22850631 16126725 11113628 25468996 9326449 17524503 17057644 7876318 11401320 22715382 7954478 18593907 21152425 22375065
PDCD4 EIF4B â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 12482958 17053147 17968323 17991735 18372920 19356152 23070007
RPS6KB1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17053147 25220053 19339977 16286006 20647036 17664694 11108711 19413330 19664995 15507151 16083285 20068231 16763566 18423201 22579465 29494492 21233202 19720745 12713446 15071500 29547541 23317821 22253885 19651622 15905173 17924679 16404421 18707149 20832730 29301334 17052453 15212693
AKT1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18836482 17570479 25749412
RPS6KA1 EIF4B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15187187 21233202 17924679 16286006 16083285 15071500 17664694 16763566 19114553 19413330 15239952
CCNE2 SKP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
SKP2 CDC25B â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
SP1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16969077 16883603 19329185
AKT1 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23807222 28446188 22733130 19270695 20160512 19549334 21963805
SKP2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 11237742 12648680 11900249 16697054 18931676 19809470 15459660
SKP2 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
LRRK2 MSN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 17447891 9856983 20642453 20949042 21603132 25009464 19027715 24351927 19740074 23241358 20696313 24904275 19890007 22952686 8537411 15634677 9516463 18973807 26824392 27357661 24695735 19570025
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
HIF1A FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19492421 16399861 17536272 17942638
HIF1A IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15695372 15968405 15930297 16682453
HIF1A ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12067980 20099200 17452336 19128456 17433259
HIF1A MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16099863 17028975
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
CDC42 PAK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 10559936 11756552 29734338 15020669 16189514 11340065 15003621 20936779 10934474 11413130 17353931 22653441 11950587 26598620 11248548 9822598 18719708 10613909 10461188
SP3 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21554857 12509426 9632663 10362515 19223508 15857802 20096088 16806531 15854045 15118068 9788252 12773549 16617124 11517158 12554796 9666093 15869407 12888570 11287330 15541732 8845379 16574784 8070411
SP1 CYP1B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12801909 23376040
SP1 APOE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15670754 11229886 18467438 2188976
SP1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10720440 21447702 7497000 15345673 17170218 7491107 17049831 17014845 10982795 17486080
SP1 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16518544 20121399 15270850 19134014
SP1 CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11742542 14563703
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 ABCB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18234965 7565762 10411657 23133566 10860921 9458366 17363581 7621073 8103518 10644769
SP1 IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8940191 8184747 11026572 14593001 12217897 8910531 7896792
SP1 ITGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8887648 20090957 11238113 11313353
SP1 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 16453304 19061309 19853299 16575904 21045016 10506168 21520171 21469139 15317818 17258390 19126647
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11910354 12473536 9223667 15067326 21831840 17283128
CSNK2A1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9153193
FGF2 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 9242465
FGF2 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 22298955 16597617 866304410574949 9045692 15780951 10574949 8663044 25772309
FGF2 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17145710 15096041 8868466 10490103 16597617 11030354 23597562 1722683 14613973 17086194 14505356 9174056 7730326 25772309 11786412 16829530 10950949 23597563 10574979 26267536
GAB1 FRS2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGFR1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12767520 17496910 17673906 25467007
NRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 11447289 11777939 11997436 11877385 12040186 9660748 15173823 25394172 23331499 6321473 16189514 19568798 14585353 17496910 9632781 10629055 21765395 11274345 15574420 9182757 11090629 15567848 16488589
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
EZH2 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 22179855 22312437 21512140 23933322 24737471 23932971 23918806 19053175 19502792 24928441 23424038 24032713 24474760 20634887 18704159 24652950 22072987
DNMT1 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17172825 18704159 21779870 21150308
FGFR1 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12601080 15592455 15951569
FGFR1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17496910 25241761 22558232 11401320 12040186 19568798 14585353
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
RPS6KB1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 21283818 17081983 16953237 24931005 11287630 15249583 27898058 16914728 25379019 23565163 15364919 15533996 19121779 9312143 17709744 20074531 22523661 23958494 16129690 23006971 23898460 26474286 28342808 17507185 25813876 26926384 15306821 20932932 34013180 15199052 18498745 18952604 18220336 12006582 19369195 29496905 27889207 26666849
IKBKB IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 10722755 19651622 24337154 18443205 23050932 15199052 20953398 25381390 16129690 29767231 11606564 18077418 14583092 15613682 16099428 12351658
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
RPS6KA1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17709744 15364919 17081983 21798082
IGF1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 26474286 28545881 26956053 25886138 15952059 18762365 22362362 19762915 11160134 22941977
IGF1 IGF1R â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11237532 12181198 17145802 19631971
IGF1 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 21798082 23331499 8452530 21071413 12067807 1852007 21645859 8408032 14604834 19258508 11287679 23675206 19029956 2877871
IGF1R CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17496910 22558232 12040186 19568798 14585353
IGF1R YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16931767 9111084 12175651
IGF1R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8662806 9852124 10471495
IGF1 MMP2 â—¼   CLEAVAGE ✅ 6.0 1.0 Reactome 8817670 9922210 7523391 12379487 12466191 17047378
AKT1 MMP2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 17409395 17680028 18471976 19440036 19930715 19945467 20214616 20398329 20609352 21084277 22131018 23572150 23589069 24030100 25136802 26597054 27328425 27510662 27572739 29556339
CSNK2A1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 29732088 17374729 21506126 11689703 10671551 12149249 15818404 10747897 10837139 20976471 19662498 21285348 11035045 11707428 21735093 17444818 20558317 11972058 16707567
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18578522 10896934
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 ITPR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24947355 18250332 16332683 18955969
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26553800 24492612 27521372 26216216 25949795 21151116 21565170
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17053147 17081983 18296647 18187866 17287340 16357133 16964243 18669648
AKT1 ILF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20870937 18097023
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 UBE2S â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29562639 27593939
AKT1 YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11943559 23331499 25241761 21071413 12183455 15149849 11438723
IKBKB NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
NFKB1 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14688340 11058167 10657616 10940886 18690006 11792125 17982049 9464836 17924060 7565674 14976188 9234715 12077291 9497375 17579043 19299558 22427889 16166378 15270850 9808189
BTRC NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12482991 10835356 11158290 11953428
RSF1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15242768
IKBKB NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 31598684 11976329 16713569 10469655 29485707 26999213 12842894 10835356 27187478 27402796 18782567 27554194 12482991 25241761 10022904 15199157 19519322 15489227 19250910 15212693 11158290 11297557
PAK4 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28007610 22173096 26068882 25560280 23543898 30755582 29330094 29399291 25335797
FGFR3 GAB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
BTRC PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 18296647 23056346 19797085 15071497 15688063 16371461
RPS6KB1 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 17053147 19339977 28692058 16286006 19901084 27028868 20647036 11108711 23415227 12482958 18296647 18423201 23466868 21233202 25573956 19720745 12713446 16357133 21378410 28899909 15905173 20661426 20832730 24405715 17052453
HBEGF ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 1840698 23331499 10209155 9135143 12621152
CSNK2A1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15064744
YWHAE YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 20936779 20618440 17085597 21827211 12426317 15071501 12657644 17979178
CAMK2D HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22360269 17179159
ERBB2 ARHGEF12 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12220504 15210733 12196628 12730235
CSNK2A1 CDC25B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12527891
RPS6KB1 EIF4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17053147 21233202 15905173 19339977 19720745 16286006 12713446 20647036 20832730 18423201 11108711 17052453
CTNNB1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
CCND2 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10385618 9736735 12006580 10498883
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
CSNK2A1 PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8972483 9558331 20068231 9990034
CSNK2A1 ABCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22695718
CSNK2A1 CAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12743374 16527823
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
BTRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 23514615 17053147 22912335 17145710 27001857 20531388 18851830 12820959 24451375 18805092 25900982 11818547 16798748 19061640 19956254 23331499 24912152 19150432 22017875 24501426 28018973 16376880 21466614 27316454 19053519 26506240 14516475 25149538 10023660 22682247 10228155 9461217 24464578 18354482 26091241 10074433 12114015 9990852 14706645 18650423 25873176 19966869 25515538 20851351 22730322 24469040
ERBB2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17496910 7702605 7999105 22558232 14517306 11245482 11950845 12040186 19568798 23576562 14585353 23640056
AKT2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 17287208 20398329 21506126 20028971 12040186 18218901
FBXW11 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23331499 9784611 22682247 10074433
FZD5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
AKT3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MET CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17496910 25163657 24511551 22558232 11929826 16909210 24342833 12040186 26654598 19568798 14585353 23083465
APC2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 23840886 10021369 8638126 16510875 10980707 10074433 9823329
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
ERBB2 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 10839362 8816440 24557338 16767099 21203579 10572067
PSEN2 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
PSEN2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
PSEN2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
MET GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10978177 17389395 19901323 10753869 15574420 15212693 10913131 10734310 11896055 20068231 10995442 9890893 16497976 14685170 17016520 18669648 11779868
E2F2 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
NRAS ERBB3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
SP3 MMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10506168 15317818
PSEN2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
SP3 CTSL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11742542 14563703