Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
MYC HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
MAPK1 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 RPS6KA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
UBE2I MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
NR4A1 RPS6KA6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RPS6KA2 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11883936
RPS6KA2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15342917
TSC2 TSC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6547838 9580671
ESR1 TSC2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 15039427 15851513
MYC CEBPZ â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
RRP1B DDX18 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20926688 24981860
MYC DDX18 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC DNMT1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC NOC2L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29467282 17353931
MYC RRP1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 30415952
MYC TOP2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MAPK3 RPS6KA2 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ESR1 RRP1B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 21182205
ESR1 RXRA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 9121466 23403292 9717844
MYC TSC1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28205554 29467282 28628118
MED24 RXRA â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16189514 9653119
RPS6KA2 RPS6KA3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
MAPK3 RPS6KA3 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CEBPZ NOC2L â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
NOC2L CEBPZ â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 26344197
RPS6KA3 RPS6KA6 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
RPS6KA2 RPS6KA6 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
ESR1 H2AZ1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19515975 23108396 20023423
CENPB RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LMO4 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ERG28 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ADIRF RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 SPTBN4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 CEBPZ â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 CLEC3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 DHX34 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DNAJC13 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DNMT1 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MED24 ESR1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12837248 11867769 31527615 9653119
ESR1 HMGN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8700510 17938209 18414489
RXRA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
ESR1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
FBN3 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HSP90AB1 NR4A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 RPS6KA3 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MAPK1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15851026 17671177
RPS6KA6 MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 MASP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MASP1 RPS6KA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MED24 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 MPP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RBPJ MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18490439 10644343 16847353
RBPJ RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 RPLP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UFM1 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SPTBN4 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SYNE4 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ZNF746 RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RXRA RPS6KA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 ZNF227 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RPS6KA6 SAP30BP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK1 RPS6KA2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CEBPZ NOC2L â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TSC1 TSC2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDC37 HSP90AB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MYC H2AZ1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18414489 22055461 12695333 11085504
MYC ATF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12695333 23612979
RPS6KA3 ATF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23975372 15109498 22052162 27321283
MYC DDX18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12747840 14519204 8861962
DNMT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21655924 20946668 17172825 15746193 22975348 12789259 19001520 24058781 23242655 22558281
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
RPS6KA3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11139588 23936765 17570479 19925796 11432835 11507039 19112174 9528769 7838153
RPS6KA3 HMGN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11438671 20166139 17924679 10739259 20068231 12773393
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8939914 12832467 9915826 17906627 32296183 19282669
MAPK1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10377179 17604322 12048211
MAPK1 NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11883936
MAPK1 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21988832 18156174 12016217 25241761 12832467 23602568 8939914 10480933 9915826 17906627 10980595 10856237 19282669
MAPK1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15342917 15851026 18794886
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18156174 25241761 12832467 8939914 9915826 17906627 10980595 10856237 19282669
MAPK3 RPS6KA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 23602568 8939914 12832467 17906627
MAPK3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15342917 16244323 15851026 18794886 19188143
MAPK3 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 10383391 12048211 10377179 15688020 18003614 27852823 17604322 11606411 20432439 16551633 12824162 15212693 17900311
MYC TSC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18056446 12695333
RXRA NR4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 14980220 10772826 17761950 7705655
RPS6KA3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17570479 15342917 16244323
TSC2 TSC1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
TSC2 TSC1 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
TSC2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 84.0 1.0 Omnipath 12167664 16424383 12511557 21134130 14551205 10915759 11741832 15340059 20166753 23331499 15342917 9580671 21071413 16464865 15851026 11290735 9809973 15851513 12869586 10807585 15963462 10585443 11741833 20412061 20226003 11175345 25263562 16339216 18411301 16636147 14651849 17658474 17693255 12176984 17077083
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368