Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
H2BC5 H2AZ1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
USP22 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18469533
E2F4 H2AC11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
PCNA CHAF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218806 16826239
PCNA XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
E2F4 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15510213 18319725
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
H2AX SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
H2AX H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
H2AX UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H2AX SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H2AX ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19146767 11673449
ATM H2AX â—¼   COLOCALIZATION 2.0 0.8 intact 16858402 5218840
H2AX SMARCA4 â—¼   COLOCALIZATION 2.0 0.8 intact 7914327 20224553
H2AC21 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 CUL4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
CUL4A CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
TP53 CAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15059885 18487368
H3C2 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 PARP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 XRCC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H3C2 SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
TP53 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
E2F4 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
PARP1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
SIRT1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19270680
SUMO2 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
H2BC5 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16628214 5218530
H4C6 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H4C6 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
H4C6 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18485871 23897426
H4C6 ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19146767 11673449
H4C6 SIRT1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15469825 18485871
E2F1 H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12629508
H4C6 PHF8 â—¼   DEMETHYLATION ✅ 2.0 0.8 Reactome 20622854 20622853
PARP1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
APLF PARP2 â—¼   ADP_RIBOSYLATION ✅ 2.0 0.8 intact 8201796 21812934
UBE2I ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
SUMO2 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SUMO1 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
XPC ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16849332
E2F4 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 16135806
RPA1 ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
BRCA1 ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
TP53 ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 9925639 10435622
ATR BRCA1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 23422745
RAD23B BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16712842 5218673
TP53 CASP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21859926 16177095
PARP1 CETN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
CETN2 SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
CETN2 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
CETN2 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
CETN2 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
CHAF1A XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
CUL4B CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
RAD23B CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
RBX1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
XPA CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
PARP1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
XPC CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
DDB1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
CHD1L DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
TP53 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
PARP1 CUL4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
PARP1 DDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
XPC DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20368362
PARP1 DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
XRCC5 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20368362
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
E2F1 PPM1D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912047
E2F1 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19376752
TP53 E2F4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
E2F4 HMGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12789259 18319725
GTF2H3 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8652557 10734072
ERCC3 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ERCC5 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8652557
GTF2H4 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9118947 10734072
ERCC4 XPC â—¼   COLOCALIZATION 2.0 0.8 intact 19279666 7263364
XPA ERCC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17948053
TFCP2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21655924 19966177
ESR1 HMGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17922863 18414489
ESR1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21920899 23658738
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
GTF2H2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10949034
GTF2H1 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259578 26278177
GTF2H2 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GTF2H3 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
GTF2H4 XPA â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PPM1D H2AFX â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 20101220 20118229
TP53 HMGB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547598 9472015
POU5F1 LEFTY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16954384 17068183
UBE2I MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
SSRP1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9472631 12374749
SUMO1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393906 11384992
XPC MRPS33 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NPM1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6541703 18259216
NR1H2 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17218271 20159957
NR1H2 SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17218271 20159957
OCIAD1 XPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
OGG1 XPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219057 16957781
PARP1 RAD23B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
PARP1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7986053 19779455
PARP1 RBX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
SUMO1 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19622798
SUMO3 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19622798
PSMD4 PSMC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16990800 5219132
RAD23A PSMD4 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
RAD23B SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RAD23B TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 12505994
RPA1 UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
RPA1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
RPA1 SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
ZNF512B SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
XPC SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMARCA4 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11950834 33476981
TP53 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11807984 16567167
TDG SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218717 16763556
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
SUMO3 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11451954 17938407
SUMO2 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1004248107 20534433
UBE2I TFCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
TP53 TFDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15574328 24096481
USP7 TP53 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 5215220 11923872
UBE2I XPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17693435 16030353
XPC ZNF512B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ZNF512B XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
APLF CHD1L â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
ERCC2 GTF2H3 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
H4 PARP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 19470756 33961781 20525793 27248496 30804502
TFDP1 E2F4 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24981860
MDM2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24147044 24583282 18784078 19247369
ERCC3 GTF2H3 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
ATM LARP7 â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
XPC VAT1L â—¼   KO_UP_REGULATES ✅ + 0.81 0.81 PKG 28854368
MACD1 H2AX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 H2AX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AX H2B1O â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AX CETN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AX PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CUL4A WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30655611 17041588
DPOLB SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
CHD1L RFA2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19666485 19661379
RFA4 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
RD23A RD23B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16105547 8692695
HMGB1 H4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30804502 29721183
BRCA1 H4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16628214 30804502
ESR1 H31 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
CSK22 MEN1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23508102 27705803
CSK22 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
XRCC6 H2AY â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2B1C H2AY â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
XPC H2AY â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2B1C SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
H2AW SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ALX3 SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AZ SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 24463511
MACD1 SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NAA40 SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AZ XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 24463511
H2AZ PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28242625 34079125
SPI2B SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
H2B1C SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
H2B1C XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 25281560
H2B1C H2AW â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 34079125
XPC H2AW â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AW SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AW PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MACD1 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MACD1 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MACD1 CETN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MACD1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SDC2 H2A1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC H2A1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2A1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 24463511
XPC H2B1D â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC ABC3C â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC H2B1O â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 CETN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CETN1 CETN3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L XRCC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19666485 19661379
CHD1L XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MDM2 CUL4B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28225217 22032989
NAA40 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NAA40 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NAA40 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SDC2 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 RPA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
SDC2 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 25817432
SSRP1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC CEP57 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
POLB NRK â—¼   KO_UP_REGULATES ✅ + 0.82 0.82 PKG 28854368
CHD1L H2AX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
H2AX H2B1C â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 16522924 34079125
H2AX H2AY â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 28242625
H2AX XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20085707 21679440 18406329
DPOLB XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
DPOLB APLF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
DPOLB PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
DPOLB H2A1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
DPOLB SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
ATR RFA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 17035231 24332808 15929725
RFA2 CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 SSRP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26344197 10064605 24981860 24332808
ATM RFA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 10713094 9725899
RFA2 PARP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24332808
RFA2 XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24981860
RFA4 PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA4 XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA4 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
XPC H4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30804502 27248496
H2AY H4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 25417162 27248496
H4 RBX1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22863883 30349055 30804502
H31 WDR76 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25281560 27248496
H31 H2AW â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 25281560 34079125
H2AW H2AY â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 28242625
APLF H2AY â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 27067600
H2B1A H2AY â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHD1L SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
SPI2B SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 21799911
XRCC6 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30585729
H2B1A H2AZ â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A APLF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A H2A1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
H2B1A H2AW â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 CHD1L â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 21799911
RN146 SSRP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 21799911
RN146 CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 21799911 21825151 26186194 28514442
SPI2B XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
SPI2B PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF H2AW â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF H2A1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHD1L APLF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 23926104 26186194 28514442 19661379
APLF CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF SSRP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
XPC CETN3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30251372
CHD1L PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
XPC RAD23B â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 34591642
WDR76 XRCC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25817432 27248496
WDR76 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25817432 27248496
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RPA1 XPA â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
POLB CAT â—¼   KO_UP_REGULATES ✅ + 0.83 0.83 PKG 28854368
PARP1 UBE2I â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
H31 PCNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33029857 26527279
PCNA XRCC6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 11239001 24695737 12171929
H2AX H31 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 26095369 31045206 20587414 20224553 29229926 23319141 16622419
CETN2 RD23B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 27880911 26638075 21962512 16713569 16189514
H2B1C PARP2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33961781 28190768 25281560
ESR1 MACD1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20035625 17914104
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
ESR1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15961505 31527615
UBE4B MDM2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21317885 24587254
SMARCA4 TP53 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PARP1 DDB2 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
TP53 RPS4Y1 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
PSMC5 RAD23A â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
PSMC5 RAD23B â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
H2AX XRCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15613478 33961781 23145133 20224553 28514442 18406329
PARP1 DPOLB â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 28514442 26186194 20302655 20303835
RD23B TDG â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12505994 16189514 16713569 34111398
H2B1A PARP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 28514442 20525793 26186194
PARP1 MACD1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 25735744
SUMO2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21147198 20016594 20016603 22689573 21693764
SUMO2 PARP1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 19471022 25027693 32786267 19779455 21252943 21693764
XPC XPA â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 17154534 12486030
RPA1 RPA4 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
ERCC2 GTF2H4 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
DPOLB PCNA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 25184665 14988403 12063248
H31 HMGB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29568061 29721183
H31 PHF8 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 20421419 26496610 20208542 20531378 20548336 20622853 20346720
SP16H HMGB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29721183 26344197
H2B1D H2AZ â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33961781 30021884
RN146 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 21825151 26186194 21799911
ESR1 CCNH â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 12527756 31527615
ESR1 MEN1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31527615 16651450
SSRP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
SUMO1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19779455 15561718 23871147 15576338 19596686
RAD23B PSMD4 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 20059542 7307429
XRCC6 SSRP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 30585729
SUMO1 SUMO3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24654937 25027693 17938407 21098080 15576338
GTF2H3 GTF2H4 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
ERCC2 XPA â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
ERCC4 RPA1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
H2AFX SSRP1 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
XPC H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 28242625 19805520
ATM H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 18344987 26095369 21704408 22451927 11893489 20081839 16858402 9488723 22184063 11571274 21676867 32518374 27918549
TF2H1 ERCC5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 15195146 16713569 8652557 11259578
H2B1D H4 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 30804502 27248496 30021884
H31 XPC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 25281560
H31 H2AZ â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24463511 16622419 23415232 34079125
NAA40 H2AY â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 33916271
H2B1A SP16H â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26186194 26344197
H2B1A SSRP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26186194 26344197
PARP2 APLF â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 21812934 26186194
SUMO1 MDM2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 18583933 20972456 15876874 21316347 11384992 12393906 12297306 12917636 22411991 15876864 17000718
WDR76 PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 31353912 25817432 27248496
XPC PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125 28760956
APLF PARP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ATR TP53 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PCNA UBE2I â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RAD23B UBE4B â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
XPC WNT3 â—¼   KO_UP_REGULATES ✅ + 0.87 0.87 PKG 28854368
CHAF1A PCNA â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
DDB2 RBX1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
GTF2H1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ATR BRCA1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NPM1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CHD1L PARP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 RPA1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CHD1L XRCC6 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
PPM1D H2AX â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20460517 20101220 20118229
TF2H1 E2F1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9400991 10428966
RD23B UBE4B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442
H2A1 H4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24463511
H31 PARP2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 25281560 28190768
H31 H2AY â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 25417162 24981860 34079125 28514442 23319141 16622419
H31 H2A1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24463511 24981860 28514442 23319141
H31 SP16H â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29568061 28514442 33961781 26527279
H31 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 32937373 28190768 20080577 29568061 20504901 34079125
H2A1 SP16H â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24463511
H2A1 SSRP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 24463511
PARP1 HMGB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28190768 29721183 34079125
PARP2 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12217960 11948190 19629035
DDB2 XPC â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
SIRT1 USP22 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ERCC3 GTF2H4 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
XRCC5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
ATM H2AFX â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
RPA1 XRCC6 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SIRT1 TP53 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CUL4B DDB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
H2AFX PARP1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
PCNA ERCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10408173 16189514 9305916 16713569
H2AX H2B1D â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 30021884
H2AX PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28796254 28242625 16377563 27728808 18406329 28514442 20000738 20085707 16522924
RFA2 MEN1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12509449 16189514
TF2H1 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10949034 31527615
NAA40 H4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25619998 33916271 30804502
H2AZ H4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24463511 22493515 27248496
H4 WDR76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30804502 31353912 27248496
H4 SP16H â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 30804502 27248496
H31 XRCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20080577 29568061 20504901 26527279 34079125
H31 XRCC6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25281560 20080577 21187428 29568061 20504901 26527279 34079125
H2AY PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 23473667 17322296 25417162 17158748 28242625 25306110 34079125
H2AZ H2B1C â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 24463511 34079125
H3C2 H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 7219095 19498464
PARP1 APLF â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26186194 17396150 18172500 20098424 28514442 27067600
E2F4 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9244350 21102443 16713569
BRCA1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
PARP1 E2F1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20133863 14627987
XPC ERCC3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26278177 10734143
MDM2 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12897156 17545634 10766163 11178989 16713569 31012223
TDG ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12874288 16282588
ATM IMUP â—¼   KO_DOWN_REGULATES ✅ - -0.9 0.89 PKG 28854368
H2AFX XRCC6 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
ESR1 H2AZ1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19515975 23108396 20023423
TFDP1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7734951 14618416
E2F4 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17671431
H2AX BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18344987 12419185 26095369 20681793 19805520 18001825 31501894 26121674 10959836 12485996 18001824 19766185 11927591 34321665 29499138
H2AX PPM1D â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 20118229 071696 8288827
XPA RFA2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10982866 33961781 12527904 7876167 20670893 32296183 19996105 11081631 9535929 20304803 7565690 8972858
CCNH TF2H1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9852112 26340423 7533895 10734143 33707221 11259578
TF2H1 ERCC2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 9130708 26340423 8152490 11071939 8652557
XPC TF2H1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26278177 10734143 11259578
TF2H1 ERCC3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15220921 17643375 33961781 9130708 24981860 9173976 26344197 22939629 26340423 33453189 19934020 8194528 10403766 8692842 8652557 28514442 9118947 11259578
H2A1 H2B1C â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24463511 27462807
PHF8 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20531378 20210320
XRCC5 APLF â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17396150 20098424 26186194 23178593 28514442
RPA1 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
ATM TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15838517 15494392 15140942
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CCNH GTF2H4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19172752 26340423 10734072
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
E2F4 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14576826 10208422
E2F1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10914734 20837136
E2F1 GTF2H4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
E2F4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
E2F4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17531812 12789259 20946668
E2F4 GTF2H4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799066
E2F4 MT1G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15735762
ERCC5 ERCC2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8652557 16189514 16713569 32245994
TP53 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8612585 16713569 7663514
GTF2H3 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9118947 8652557 10734072
RPA1 ERCC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
ERCC5 ERCC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14517266 19940136 17948053
ESR1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15961505 24119295 18404132
TDG ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12874288 17129768
GTF2H3 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8652557 15790571 10734072
NPM1 SUMO3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17535915 25218447 19240082
USP22 SIRT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26049753 32763411 28417539
SIRT1 XPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20670893 30327428
TP53 SUMO2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
TP53 SUMO3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
SUMO3 TDG â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 25027693 11889051 16620772
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22939629 15367688 26496610 26774286 21172662 11196700 15520013 22863883 21679440 17159921 30021884 14681455 26446488 26344197 10207052 30585729 17308091 11493912 10757784 10219089 10984620 19118032 12145306 32296183 28035050 19177010 18809223 21454661 15910003 10783163 28514442 21070772 25574025 15023334 7699019 10750018 10446239 22451927 33005030 9488450 17283121 19906305
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
POLB MT1E â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
XPC SPP1 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
CHAF1A H3C2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 7219095 19498464
H3C2 CHAF1A â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 7219095 19498464
H3C2 CHAF1A â—¼   PROXIMITY ✅ 0.91 0.91 mint 25281560
ERCC5 GTF2H1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
TP53 USP7 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
H2AX SSRP1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 24981860 28514442 18406329 16522924
H2AX SP16H â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 24981860 28242625 28514442 18406329 16522924
SSRP1 H4 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 28514442 30804502 21969370
MDM2 USP7 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 SDC2 â—¼   KO_DOWN_REGULATES ✅ - -0.93 0.92 PKG 28854368
CUL4A DDB2 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
RAD23A XPC â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
XPC GPC4 â—¼   KO_UP_REGULATES ✅ + 0.92 0.92 PKG 28854368
XRCC5 XRCC6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
XPC NODAL â—¼   KO_UP_REGULATES ✅ + 0.93 0.93 PKG 28854368
ERCC4 XPA â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
RD23A XPC â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 33961781 24258024 16713569 9164480 9372924
H31 SSRP1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 33961781 15616580 29568061 28514442 26527279
TFDP1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
RAD23A PSMD4 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 12970176 5216668
SMARCB1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
SUMO2 TDG â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
ATM NODAL â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
HMGB1 TP53 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ERCC5 TDG â—¼   KO_DOWN_REGULATES ✅ - -0.96 0.95 PKG 28854368
GTF2H1 XPC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
XPC IMUP â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
H2AX H4 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 26095369 24981860 20224553 18285460 27248496 28514442 20000738 16522924 30021884
RD23B XPC â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 28514442 33961781 24258024 24981860 28760956 28473198 21962512 17154534 10488153 22431748 16713569 10873465 9164480 9372924 11279143 9372923 9734359 11259578
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
ATM ATR â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SUMO3 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ERCC3 ERCC2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 15220921 27193682 16669699 33381997 22939629 26340423 8152490 8652557 9118947 22678362 19934020
USP7 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6799761 18566590
USP7 TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5215220 11923872
TP53 USP7 â—¼   DEUBIQUITINATION ✅ 0.97 0.97 mint 5215220 11923872
SUMO1 TDG â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
APLF XRCC6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
APLF XRCC5 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CETN2 XPC â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
RAD23B XPC â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
E2F1 TFDP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
E2F4 TFDP1 â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
RD23B PSMD4 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 16990800 32296183 26344197 14585839 10488153 12832454 16713569 11827521 20059542 16189514
RD23A PSMD4 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 16990800 19013454 32296183 29997244 10488153 17408689 16713569 11827521 14621999 16105547 20059542 16189514 14557549 12970176 31467278
H31 H4 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 18571423 19498464 14578449 30804502 16622419 19766566 20498094 20739937 25533843 20080577 26527279 8598932 22828868 27248496 28514442 25416956 21724829 34079125 29568061 14718166 23319141 19410544
SSRP1 SP16H â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 27173435 24981860 19214185 26344197 16682447 16713563 22939629 16902406 21055985 28514442 22863883 12393879 30021884
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
PCNA RPA1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ERCC2 GTF2H4 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PSMD4 RAD23B â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SUMO2 UBE2I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ERCC2 GTF2H3 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
TDG LEFTY1 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
CCNH GTF2H3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD4 RAD23A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SMARCA4 SMARCB1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCNH GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCNH ERCC3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCNH ERCC2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ERCC3 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ERCC3 GTF2H3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ERCC3 GTF2H1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H1 GTF2H3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H1 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H3 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMC5 PSMD4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
DDB2 LARP7 â—¼   KO_UP_REGULATES ✅ + 0.99 0.99 PKG 28854368
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CCNH GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
CCNH GTF2H1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERCC2 GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERCC2 GTF2H1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERCC2 ERCC3 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
ERCC3 GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
GTF2H1 GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
GTF2H2 GTF2H3 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
GTF2H2 GTF2H4 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PARP1 POLB â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PCNA POLB â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PARP2 POLB â—¼   PHYSICAL_INTERACTION 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
POLB PCNA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB RPA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
PARP2 POLB â—¼   SHARES_COMPLEX 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
PCNA POLB â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PARP1 POLB â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PCNA CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA PARP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA H2AFX â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA ATR â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 1974050 19793801 19847258 20051983 22021614 23414611
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
PCNA ATR â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 1974050 19793801 19847258 20051983 22021614 23414611
PCNA H2AFX â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA PARP1 â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 10858306 11756412 11948190 12637553 14624239 14726013 15703371 15871698 16442856 16697054 16731526 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20056333 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
E2F1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7623816 12782299 14618416 20580656 9389735 11133765 8903355 9649317 23078099 12468739 1261188
ERCC5 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 18079701 10408173 16713569 19279666 9305916 20713449
E2F1 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15510213 18319725 11491305
XRCC5 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H2AX ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
ATR H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 20461094 20976184 20471486 22224778 17303408 28797244 18677104 19622404 15798197 19793801 9488723 20860841 12919958 18158901 20165693 20936109 22002605 26114388 29114052 21283714 22819196 19282663 24893124 17116885 22531632 17582221 30013081 25438756 26019182 17384638 19647519 20205745 23166506 25852739 18471973 27442013 22247744 29584802 20542002 19875294 25249630 20368801 15459660 27332952 27715493 19772495 25247188 17296725 11877377 14643438 24813610 20613862 17102137 20847938 21148072 23443128 27431324 29163782 23754961 17690115 15975956 18663141 21787120 22545090 27077811 19781914 27164092
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
ATM H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 197.0 1.0 Omnipath 27410735 28544233 16426903 28797244 9488723 23847653 30197789 21930799 18158901 21693595 18848500 22819196 15603757 16760673 17570479 24688021 24793032 27458206 16531125 22028490 30154456 19230794 23202908 25852739 19059218 26073471 22247744 28259974 29584802 25691887 19049966 20368801 26700820 29386061 28124509 20613862 27550454 20847938 27388041 27752097 23269287 24480460 22237206 20461094 20971043 26941327 18285803 21690091 15279774 23891287 25847270 24490130 25349305 26906421 20637859 26314960 15286739 27780918 20454618 30013081 28671946 25218945 23742011 26391293 23972723 23382699 26416514 27442013 20703100 24726884 26512707 27332952 29641431 25287622 26295265 14643438 29163809 25264544 19895790 26504743 26113859 27431324 28790385 18413980 21283714 21787120 20205745 19781914 25093845 27135971 23227178 22224778 20923785 20860841 24244154 23386996 30065307 16858402 11879731 28009280 23343929 20192759 22761798 26855420 24378750 20068231 20580718 14504478 24893124 29048667 25661368 26860083 26019182 20488183 28764946 22205726 23977391 18471973 19591958 28239143 20542002 17525332 20495376 18755145 23050241 17782711 11571274 19473884 28431265 25742493 18248856 17690115 20684759 26317467 21727091 24651472 25827888 27164092 28587922 20976184 30723510 20471486 23772364 29794999 11893489 19014481 20165693 26671524 16997395 20936109 26114388 23845989 15138496 22761813 23355489 27455285 28943310 21348461 19647519 23678292 23166506 28099474 29434792 25249630 25269479 27310012 15177039 22559321 26045162 20865059 22972376 21148072 26760771 21188122 22962268 22768044 26711340 20460517 27845910 28855246
PPM1D H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20118229 20101220 20460517
RPA1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
XPA CUL4A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DOT1L H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12123582 18022353
XRCC5 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H4C6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
E2F4 H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 11799066
APLF PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18172500 17396150 20098424
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
XRCC5 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H2AFX ATM â—¼   PHYSICAL_INTERACTION 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
H2AFX ATM â—¼   SHARES_COMPLEX 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
H2AFX ATM â—¼   ENZYMATIC_REACTION ✅ 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATM PARP2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM PARP1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
H2AFX ATM â—¼   REGULATES ✅ 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATR ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15510216 10608806 17478428 17124492
PPM1D ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15510216 19360021 16949371
ATM RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17525332 11359916
ATM SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22588298 23277204
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATR RPA1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR PARP1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR PARP2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR MDM2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR BRCA1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR H2AFX â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR XPA â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR RPA1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR RPA1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
ATR MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 14654783 17296725 20651945 11877377 19788416 18677104 19282663 15798197 17102137 17116885 17582221 19622404 19793801 17384638 15459660
ATR BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 26927092 17478428 24746700 15159397 17531442 10866324 18677104 19622404 15798197 19793801 20860841 16713569 11114888 23422745 20936109 16322207 19282663 20068231 17116885 17582221 25879655 10608806 17384638 23346553 12773400 12183412 17525332 15459660 11278964 17296725 11877377 17102137 10550055 16522651
ATR TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17145710 22778941 24395704 28468838 12401524 15159397 24877058 15254178 9733515 11483158 15806145 19056039 11875057 15865930 11551930 11883897 19923893 12548019 18697815 29170437 16293623 19010925 11709713 10446957 9363941 21748595 17272272 22797063 12242661 10196661 22084686 10747897 10608806 10673501 12091386 17118344 23892398 9765199 15489221 24037342 15140942 10435622 17241873 10597277 10801407 11711532 17174997 21593792 25201202 9843217 10606744 15024084 15226429 15922368 21415014 21480565 15585169 24947324 9925639 23380594 9733514 11865061 19625493 16390936 10951572 10570149 23311997 12111733 26144601
ATR XPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 19004803 27247238 18677104 19622404 15798197 19793801 23861882 23178497 27827925 18594563 19282663 17116885 17582221 18790090 17384638 20451471 19586908 15459660 16540648 17296725 11877377 24947324 17102137 30327428
ATR E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 22184068 11459832 15494392 15140942 26843428 27028861 20413589 27025900 24741006 23202967 25101673 27903963 27827925 15838517 22174788
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 PARP2 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 H2AFX â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 SUMO3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20016603 25218447 20016594 21147198
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 PARP2 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 H2AFX â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 XPC â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 DDB2 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
E2F4 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20133863 21701264 17531812 17001309 20818429 17106239 23108140
BRCA1 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20160719 18851829 9000507 21407215
E2F4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9244350 18319725 16713569 12909625
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
XPC CETN2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11900249 12648680 15703371 16697054 17884153 18199748 19809470 19847258 20211143 20457011 22615860
XPA CETN2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
XPC CETN2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11900249 12648680 15703371 16697054 17884153 18199748 19809470 19847258 20211143 20457011 22615860
PARP1 CHD1L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22146311 19666485
CSNK2A2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16083285 1088347 10348343 10884347 16552184 9315650 10747897
RPA1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA CUL4B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RPA1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA DDB1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
RBX1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
XPA DDB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
E2F1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9418871 19376752 17173070
DDB2 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15882621 22039351 19740755 29604309 23319653
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
E2F1 MT1G â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15731768 15735762
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
GTF2H1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15123636 10428966 16213134
PARP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14627987 20133863
E2F1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20211142 15133492 22327218 7892279 16360038 9199321 8405995 9704927 8816798 9780002 8657117 9464260 22629304 7739537 27705803 25368385 9501179 8816502 8832394
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
E2F4 WDR76 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 11799066
GTF2H1 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9130708 8652557 10734072
ERCC5 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8652557 16713569 20840796
ERCC2 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10734072 8652557 10024882 16669699
ERCC2 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12820975 10734072 9771713 8652557 16189514 19934020
GTF2H1 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10403766 10734072 9173976 8194528 15220921 9118947 9130708 8652557 11259578 26340423 17643375
ERCC3 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9118947 8652557 16189514 10734072
RPA1 ERCC5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17000769 9699634 7700386 15590680 9716411 17466625
ERCC5 GTF2H1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15195146 16713569 8652557 11259578
SSRP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15171726 23810005 1406642 19946334
ESR1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18234909 11522780 9869301 10428965 12761896
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
ESR1 PSMD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18457947 9253789 12648521 11696545 23580568
ESR1 MACROD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17893710 18206366 19403568 15691879
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
GTF2H1 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21988832 10734072 11062469 9130708 8652557 8194529
PARP1 H2AFX â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12607003 14726013 15175241 15459660 15703371 16581787 16697054 17088286 17116881 17303408 17713585 19208614 19364882 19772495 19847258 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9488723
TP53 HMGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
HMGB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9472015 23063560 11748221 16713569 11106654
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
UBE2I MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
PPM1D MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18265945 17936559 17939684
USP7 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 17936559 26460617 15916963 24462112 22056774 18566590 20816748 16402859 20713061 16943424 17380154 29236775 16082221 26238070 34799561 16845383 16474402 28406480 27452404 28196907
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
TP53 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21611785 11713584 10365096 15217513 16258956 14675138
NPM1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 22955283 31434245 16009132 12748172
NPM1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 23443559 15144954 16740634 15310764 16376884 12080348
TP53 OGG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16293709
PARP1 XPA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
PARP1 PARP2 â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 18835851 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21037379 21060331 21076181 21270334 21337561 21376743 21818122 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
PARP1 SUMO3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19779455 25218447 23750026 24782567
PARP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9312059 17891139 15044383 12898523 14627987 16713569 9565608
TP53 PPM1D â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18333294 19015127 11101524 22405851 20093361
PPM1D TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15870257 17936559 23666059 28903382
XPA RAD23B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RPA1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA RBX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
XPA RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12527904 19446504 7665601 8972858 7876167 20304803 7565690 9535929
SIRT1 XRCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17334224 16189514 15205477
SIRT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18235502 11672523 18235501 15205477 35931247 15989956 17964266 25280219 19047049 16713569 19960022 21245319 12006491 19590512
SMAD1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10625647 21467818 19664780 20965237 14672939 21276840
SMARCB1 SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 18414052 23540691 20506188 8895581 31759698
XPC SMARCA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19740755
SMARCA4 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19740755
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
SUMO1 TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 16763556 15959518 17060459 21284855 20504299 16189514 16524884 11889051 10961991
UBE2I TDG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15823533 18691969 21284855 15959518 11889051
TDG XPC â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 16713580 17129768 17855402 17884153 18199748 18543256 19809470 19847258 20211143
TDG XPC â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 16713580 17129768 17855402 17884153 18199748 18543256 19809470 19847258 20211143
UBE2I TDG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18512959 24753249 18691969
TP53 XPC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12771027 22336944 12242345 23050045 16357511 12967652 15927209
TP53 USP7 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 16402859 15053880 16474402 11923872
USP7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 26460617 21845734 23382381 16713569 25283148 15916963 18375498 19918835 24462112 22056774 17268548 22653443 23388826 21170034 20816748 17525743 16402859 11923872 17380154 16082221 26238070 16845383 16474402 35538032 22084066
TP53 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12771027 9346961 10779360 21340684 19004803 10367887 20066118 12496474 12242345 20457558 20182602 10962562 6396087 9892649 12967652
TP53 VAT1L â—¼   KO_DOWN_REGULATES ✅ - -1.07 1.06 PKG 28854368
XPC LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.08 1.08 PKG 28854368
PARP2 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.1 1.09 PKG 28854368
XPC MT1G â—¼   KO_UP_REGULATES ✅ + 1.1 1.1 PKG 28854368
XPC NRK â—¼   KO_UP_REGULATES ✅ + 1.12 1.12 PKG 28854368
DDB2 WNT3 â—¼   KO_DOWN_REGULATES ✅ - -1.13 1.12 PKG 28854368
DDB2 NODAL â—¼   KO_DOWN_REGULATES ✅ - -1.17 1.16 PKG 28854368
TP53 WNT3 â—¼   KO_DOWN_REGULATES ✅ - -1.19 1.18 PKG 28854368
XPC MT1E â—¼   KO_UP_REGULATES ✅ + 1.19 1.19 PKG 28854368
XPC AKAP2 â—¼   KO_DOWN_REGULATES ✅ - -1.21 1.2 PKG 28854368
PARP2 MT1E â—¼   KO_DOWN_REGULATES ✅ - -1.27 1.26 PKG 28854368
XPC TSPYL5 â—¼   KO_UP_REGULATES ✅ + 1.27 1.27 PKG 28854368
XPC CAT â—¼   KO_UP_REGULATES ✅ + 1.29 1.29 PKG 28854368
POLB WNT3 â—¼   KO_UP_REGULATES ✅ + 1.32 1.32 PKG 28854368
XPA SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.35 1.34 PKG 28854368
DDB2 E2F4 â—¼   KO_DOWN_REGULATES ✅ - -1.36 1.35 PKG 28854368
ERCC5 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -1.41 1.4 PKG 28854368
PARP2 TFCP2 â—¼   KO_UP_REGULATES ✅ + 1.42 1.42 PKG 28854368
DDB2 MACROD1 â—¼   KO_UP_REGULATES ✅ + 1.5 1.5 PKG 28854368
POLB MT1G â—¼   KO_UP_REGULATES ✅ + 1.52 1.52 PKG 28854368
POLB AKAP2 â—¼   KO_DOWN_REGULATES ✅ - -1.6 1.59 PKG 28854368
TP53 NODAL â—¼   KO_DOWN_REGULATES ✅ - -1.64 1.63 PKG 28854368
ERCC5 ERCC5 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
TDG SPP1 â—¼   KO_UP_REGULATES ✅ + 1.74 1.74 PKG 28854368
POLB LEFTY1 â—¼   KO_UP_REGULATES ✅ + 1.88 1.88 PKG 28854368
XPA LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.91 1.9 PKG 28854368
DDB2 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -1.97 1.96 PKG 28854368
DDB2 VAT1L â—¼   KO_DOWN_REGULATES ✅ - -2.06 2.05 PKG 28854368
POLB SPP1 â—¼   KO_UP_REGULATES ✅ + 2.17 2.17 PKG 28854368
PARP2 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.24 PKG 28854368
ATM ATM â—¼   KO_DOWN_REGULATES ✅ - -2.25 2.25 PKG 28854368
TP53 LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -2.28 2.27 PKG 28854368
POLB VAT1L â—¼   KO_UP_REGULATES ✅ + 2.29 2.29 PKG 28854368
POLB CHD1L â—¼   KO_DOWN_REGULATES ✅ - -2.33 2.32 PKG 28854368
DDB2 SPP1 â—¼   KO_DOWN_REGULATES ✅ - -2.54 2.53 PKG 28854368
TDG MT1G â—¼   KO_UP_REGULATES ✅ + 2.68 2.68 PKG 28854368
ATM LEFTY1 â—¼   KO_DOWN_REGULATES ✅ - -2.78 2.77 PKG 28854368
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
TDG MT1E â—¼   KO_UP_REGULATES ✅ + 3.35 3.35 PKG 28854368
TP53 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -3.51 3.5 PKG 28854368
ATM MT1E â—¼   KO_DOWN_REGULATES ✅ - -3.51 3.5 PKG 28854368
DDB2 MT1G â—¼   KO_DOWN_REGULATES ✅ - -3.53 3.52 PKG 28854368
XPC HIST1H1A â—¼   KO_DOWN_REGULATES ✅ - -3.58 3.57 PKG 28854368
POLB HIST1H1A â—¼   KO_DOWN_REGULATES ✅ - -3.69 3.68 PKG 28854368
ATM SPP1 â—¼   KO_DOWN_REGULATES ✅ - -3.83 3.82 PKG 28854368
TDG TDG â—¼   KO_DOWN_REGULATES ✅ - -3.98 3.97 PKG 28854368
DDB2 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -5.71 5.7 PKG 28854368
ATM MT1G â—¼   KO_DOWN_REGULATES ✅ - -5.86 5.85 PKG 28854368
DDB2 MT1E â—¼   KO_DOWN_REGULATES ✅ - -6.27 6.26 PKG 28854368
PARP2 PARP2 â—¼   KO_DOWN_REGULATES ✅ - -6.68 6.67 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368
XPC TFCP2 â—¼   KO_UP_REGULATES ✅ + 7.57 7.57 PKG 28854368
POLB RPS4Y1 â—¼   KO_DOWN_REGULATES ✅ - -8.0 7.99 PKG 28854368
XPC RPS4Y1 â—¼   KO_DOWN_REGULATES ✅ - -11.64 11.63 PKG 28854368