SUMO1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
UBE2I
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
ATM
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
CCT8
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
YY1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
22025288
18558095
|
ESR1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24559156
10851069
|
COIL
|
FXR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
FXR2
|
TFCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
FXR2
|
GFAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
FXR2
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
NR1D1
|
HUWE1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
1000438107
20534529
|
MAPK1
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
ESR1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23250869
22430216
|
MAPK1
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15778365
|
MAPK3
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219611
17290218
|
MAPK3
|
PCBP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17475908
|
PHF1
|
TFCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
SIN3A
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17036045
5219211
|
SUMO1
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25704882
22493095
|
SUMO1
|
SRF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12788062
|
SUMO1
|
YAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19788416
|
TF
|
IGFBP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11297622
11749962
|
YY1
|
ACTA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21169469
23705901
|
CBX8
|
BMI1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17332741
5219708
|
CBX8
|
RNF2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17332741
5219708
|
HSPB1
|
GPANK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
POMC
|
OPRM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
7905839
8208289
|
HBB
|
HBA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
NFE2
|
HBA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17196618
12920035
|
HBB
|
HBA2
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
PIN1
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PIN1
|
ZCCHC10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
TFCP2
|
COIL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
MECP2
|
CRH
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17108082
|
ESR1
|
CRH
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8408641
|
PCBP2
|
PCBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
PCBP1
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
PCBP1
|
ZCCHC10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22365833
8293266
|
HSPB1
|
CRYAA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11700327
5214764
|
ESR1
|
PTPN6
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
6673088
7539106
|
PPP2CA
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20704570
23331499
|
TFCP2
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
10586050
23220634
|
ESR1
|
MMP9
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10935492
12878732
|
FN1
|
BCAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16581250
8649368
|
PPP2CA
|
BCAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11593413
|
PIMREG
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0709227105
18757745
|
HDAC1
|
ABCB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20037778
19435809
|
UBE2I
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25704882
22493095
|
PIMREG
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0709227105
18757745
|
CASP8
|
TFCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
CASP8
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CASP8
|
APP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10409650
10911620
|
SOCS5
|
IL4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12242343
16451196
|
GATA1
|
IL4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15739164
21454593
|
TFCP2
|
IGFBP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15247904
17278996
|
ESR1
|
BMI1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24559156
16582100
|
CD79A
|
FN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6491104
18243143
|
UBE2I
|
TFCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
HSPB1
|
PIAS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
MECP2
|
PIAS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PIK3CB
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PPP2CA
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
APP
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PPP2CA
|
TFCP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20682773
|
YWHAZ
|
EIF3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217040
15161933
|
TFCP2
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21655924
19966177
|
ESR1
|
BDNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16262660
7479947
|
ESR1
|
HBB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14695898
18252963
|
PRL
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25193864
19524120
|
HSPB1
|
MECP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FOXA1
|
RET
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21947652
|
TFCP2
|
RET
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24150225
22615490
|
ZCCHC10
|
PPIG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22365833
8293266
|
TFCP2
|
NEDD9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
FAM120C
|
TFCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
TFCP2
|
SAA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10455131
10899169
|
TFCP2
|
H1-2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20701767
25165434
|
ESR1
|
UBE3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
9891052
16772533
29388081
16314411
31329371
22865929
|
UBE3A
|
RING2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
20351251
26216987
30040487
33542309
|
ATM
|
HUWE1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22213803
17478428
|
BMI1
|
FXR2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24457600
34316702
|
MECP2
|
FXR2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
ESR1
|
HUWE1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19805454
25604459
|
ESR1
|
RBBP6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20184719
31527615
|
SUMO1
|
SIN3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17036045
24654937
|
HDAC2
|
RING2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19293945
24457600
|
TFCP2
|
IP6K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
PCBP3
|
PCBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34133714
33961781
|
STK35
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
FOXC1
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25609649
29091762
|
MTDC
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
F19A3
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
TFCP2
|
TF2L1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
TFCP2
|
LTOR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31501420
|
F19A3
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
STK35
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MTDC
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MORF4L1
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
828.0
|
0.82
|
STRING
|
36370105
|
MAPK3
|
HSPB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
25241761
21575178
8774846
|
BMI1
|
XRCC5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
20668194
24457600
34316702
|
PCBP1
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
HSPB1
|
GATA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
32814053
20410505
|
ANM6
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
ANM6
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
ANR29
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
TFCP2
|
DJC27
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
32296183
25416956
33957083
|
ANR29
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
HDAC1
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
ESR1
|
SUMO1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
31527615
15961505
|
YWHAZ
|
YAP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.84
|
0.84
|
mint
|
5217040
15161933
|
ESR1
|
FOXA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
28336670
23403292
25303530
27926873
|
DDX5
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
841.0
|
0.84
|
STRING
|
36370105
|
SMAD2
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
10199400
11226163
31130994
14699069
|
SMAD2
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20207742
11555647
|
HDAC1
|
MECP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
858.0
|
0.85
|
STRING
|
36370105
|
HUWE1
|
HSPB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
25147182
25277244
|
ESR1
|
MEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16651450
31527615
|
PPIG
|
PCBP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
27684187
22365833
|
PCBP1
|
PPIG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
860.0
|
0.86
|
STRING
|
36370105
|
HDAC1
|
YY1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
HBA2
|
HBB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HuRI
|
32296183
|
PIAS1
|
SUMO1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
27032383
24654937
19217413
15561718
22578841
16524884
11583632
14609633
18806873
|
PIAS1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
11117529
15666801
31527615
|
TFCP2
|
UBIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
33961781
20211142
|
MAPK1
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ESR1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
APBB1
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
9685356
16189514
16713569
|
GFAP
|
MEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
12169273
16189514
|
PIN1
|
SMAD2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19920136
19122240
|
PCBP1
|
PCBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
27684187
23640898
16713569
26344197
|
ESR1
|
BTF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
31527615
18025262
|
MECP2
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
HDAC1
|
DDX5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
20663877
20022962
15298701
19995069
17369852
|
HDAC2
|
YY1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
MECP2
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
14647463
12473678
16331260
14593184
|
NFE4
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
11003662
16263792
|
TFCP2
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19340300
|
DDX5
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
25114211
19995069
19596686
|
DDX5
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
25218447
17369852
25114211
|
DDX5
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20663877
19995069
25604459
12738788
20308691
11250900
21182205
10409727
|
MEF2C
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9069290
17210568
9988769
|
PPP2CA
|
MAPK1
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
intact
|
211739200
12840032
8214413
|
MAPK1
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16231973
12459785
23109003
|
MAPK1
|
TFCP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19237534
|
MAPK1
|
GATA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15967790
|
MAPK1
|
PCBP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17475908
|
PPP2CA
|
MAPK3
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
intact
|
211739200
12840032
8214413
|
MAPK3
|
PTPN6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16231973
12459785
23109003
|
MAPK3
|
TFCP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19237534
|
MEN1
|
SMAD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
22275377
11274402
15150273
|
NFKBIA
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
19297320
9734360
11124955
|
ESR1
|
SUMO1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15961505
24119295
18404132
|
ESR1
|
TF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12459033
|
TFCP2
|
TF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20796026
|
YY1
|
NOS2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19402223
20430007
|
HDAC1
|
YY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18634613
11486036
11940654
|
CBX8
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21282530
34316702
20543829
10825164
20601937
19636380
26496610
27705803
22325352
33961781
24981860
17332741
24457600
|
HBA2
|
UBE3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
CD79A
|
PTPN6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
23836650
7618087
9890995
|
CASP8
|
PTPN6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
8296476
18086677
706462200
|
SMAD2
|
FN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19397700
17481939
15954899
|
SMAD2
|
ACTA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21990365
17303001
15306544
|
HDAC1
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10199400
|
SIN3A
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15695521
28514442
9520398
10640275
14647463
12398767
9150133
10444591
14593184
21258344
12943729
12374985
17956988
11102443
9885572
17962807
26496610
12453419
11171972
16331260
20585571
10220385
25314079
12091390
11931768
17643391
11602581
17827154
12724404
11784859
23752268
18059533
9790534
9804427
26949739
24981860
33961781
19182791
11118440
15451426
12920132
26344197
|
ESR1
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17312152
31527615
24051437
33731348
14722073
21182205
15557281
18451880
14506733
15140878
|
SIN3A
|
MECP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22615490
10773092
14593184
15322089
11441023
9620804
9620779
23770565
|
TFCP2
|
FN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21361876
25609232
|
MECP2
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
21655924
23242655
15870696
|
FOXA1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21572391
20501593
24290378
|
ESR1
|
GJA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15028626
12810571
22962310
|
ESR1
|
RET
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21737465
21947652
22878616
|
ESR1
|
FOXC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25303530
18414489
|
PPP1R1B
|
PPP1CC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9108011
6087160
10604473
|
RET
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
MECP2
|
BDNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18599437
14593183
|
TFCP2
|
MECP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11865062
15549394
19000991
|
GATA1
|
NFE2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16648487
20564185
|
RING2
|
TFCP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11865070
18629613
16189514
16713569
|
UBE3A
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
TFCP2
|
NFE2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16648487
|
HAPLN2
|
KRT27
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HuRI
|
32296183
|
PIAS1
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
EIF3A
|
RPS24
|
â—¼ PHYSICAL_INTERACTION
|
|
|
916.0
|
0.91
|
STRING
|
36370105
|
RNF2
|
CBX8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.92
|
0.92
|
mint
|
5219708
17332741
|
YAP1
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
MRPL11
|
MRPS35
|
â—¼ PHYSICAL_INTERACTION
|
|
|
926.0
|
0.92
|
STRING
|
36370105
|
HDAC1
|
MORF4L1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
927.0
|
0.92
|
STRING
|
36370105
|
CCNA1
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
HDAC2
|
MORF4L1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
MRPL40
|
MRPS35
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
CDK2
|
CDK3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
28514442
23455922
26186194
33961781
|
HDAC2
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
26949739
|
BMI1
|
CBX8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
UBE2I
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5219915
17491593
|
PPP1CC
|
YWHAZ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
952.0
|
0.95
|
STRING
|
36370105
|
CBX8
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219708
17332741
|
BMI1
|
CBX8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219708
17332741
|
HSPB1
|
CRYAA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
11700327
32814053
12601044
33961781
|
RNF2
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
16710298
5218667
|
CBX8
|
RNF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
961.0
|
0.96
|
STRING
|
36370105
|
PIAS1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
CBX8
|
RING2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
21282530
18927235
19636380
26496610
27705803
22325352
24981860
17332741
24457600
|
HDAC2
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
25241761
9520398
11287668
19703393
30737378
17894944
10444591
11466315
11777905
21258344
15297431
17956988
11102443
9885572
12032298
19041848
26496610
22416134
12493763
11739383
10581039
11804585
11564889
21670149
22939629
9150135
11919195
23752268
18059533
16713569
9804427
20388487
9790534
26949739
24981860
33961781
15987735
19182791
15451426
12920132
26344197
|
SIN3A
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
16254079
12398767
21258344
12943729
9885572
9150134
12453419
12493763
14749338
22493095
12082111
25314079
12091390
17827154
12724404
23752268
18059533
9804427
26949739
24981860
15451426
26344197
|
RING2
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28073915
12183370
16710298
29402932
17157253
32296183
22493164
15386022
21772249
16751658
20601937
19636380
26496610
26151332
21676867
22902369
15563468
16359901
18650381
31093962
34316702
20543829
27647897
25843776
24457600
27705803
22325352
12589020
25355358
24981860
33961781
23207902
26468281
16714294
|
MRPL11
|
MRPL40
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
APBB1
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
CCT8
|
PPP2CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
SUMO1
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
MAPK1
|
APBB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
14697653
|
XRCC5
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
CDK2
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9781043
16322221
16123081
11292842
10928988
|
PPP2CA
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
15510216
|
CCNA1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
16189514
15583032
25241761
16777603
10559988
14681455
9636170
16159883
9041194
10652300
8565853
12970441
14701826
8397206
14681231
11264176
8397207
15601848
12191604
12190313
7799941
19423708
12800980
16009130
|
CDK2
|
CDKN2A
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
32.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
25002027
28536364
7575488
9618481
|
CDK2
|
BMI1
|
â—¼ UP_REGULATES
|
✅
|
+
|
32.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
25002027
28536364
7575488
9618481
|
MAPK1
|
CDK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10962581
12359725
|
CDK2
|
TFCP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
19556876
20682773
19237534
|
CDK2
|
COIL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17570479
11102515
|
CDK2
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
10428798
22431515
23390529
17570479
23770852
|
CDK3
|
TFCP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
19556876
19237534
|
BMI1
|
CDKN2A
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
7.0
|
1.0
|
ACSN
|
15640618
17936558
20818389
21383063
21678481
21685941
22796940
|
FOXA1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23443045
19340300
|
BMI1
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
21383063
9308237
21678481
17936558
22796940
20818389
11283613
15640618
19404261
21685941
|
CDKN2A
|
HUWE1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17145710
16915296
15989956
|
DDX5
|
FOXA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
17495528
15343269
19718048
11682626
28539435
14675539
|
DDX5
|
HDAC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15298701
17369852
20022962
|
FGFR1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK1
|
SMAD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
RET
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
19901323
11522789
91184134
16156666
16497976
15592455
12571246
19415658
11826406
17389395
18578522
21109534
20068231
18452278
18669648
16153436
11522288
18691976
1378617
15972258
15935618
16094384
12388769
11971971
19651622
21842857
28450419
18707149
17016520
21455180
|
PPP2CA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
12624094
12840032
18039929
16680151
16456541
10995457
18042541
10592173
7780739
18588945
2154696
20626350
|
MAPK14
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
11157753
22521293
17255949
11238443
11274345
12697810
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
GJA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
22028470
9535909
19664994
9535905
12637502
15605363
8631994
17570479
|
MAPK1
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
23331499
10197981
34504019
18775330
20659902
8226933
9620846
16156666
9604935
18988627
12193595
11027280
8388392
27153775
31995604
|
MAPK1
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
27342992
23405013
|
MAPK1
|
PLCB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11287604
11481231
|
MAPK1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
15655247
10949034
15528270
18372406
15461668
12118371
12466266
7495695
17615152
15059947
16076840
7491495
12093745
10409727
9528769
7838153
|
MAPK1
|
PITPNM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15125835
|
MAPK1
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
24342355
17290218
|
RET
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
44.0
|
1.0
|
Omnipath
|
19901323
17081983
8622669
16497976
15592455
15735649
7535770
17126298
16083285
20068231
18452278
18669648
16153436
18691976
18088087
17548358
15972258
10781613
19651622
15674326
7750576
17016520
15659558
|
MAPK14
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
23397142
11238443
11274345
12697810
|
MAPK14
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14580335
16410802
8622692
8668171
9724653
|
MAPK14
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23216744
22431515
12138194
15879307
|
MAPK14
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14970175
|
MAPK14
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
15187187
18039929
18411303
12738796
20626350
11274345
|
MAPK14
|
MEF2C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
21902831
9069290
23331499
9858528
9384584
10330143
9753748
10805738
16189514
18988627
26660426
|
FGFR1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAPK3
|
SMAD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
RET
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
551.0
|
1.0
|
Omnipath
|
15956760
25485910
17240116
20385359
12527803
17621270
23612968
18212246
21860413
18097051
18851832
10645003
25679764
21423210
15007380
19934253
19935718
22356909
9677429
15781651
10849428
17188005
20667468
14625304
34380633
17377139
21423211
20010870
26186445
20736304
12376318
33627405
16740736
21561860
15004239
17901130
15212956
15897464
15143154
18819921
17157789
26297582
12138104
11777927
22158866
23195225
34473994
20494825
14963038
16778204
17391526
27683117
22689060
12444552
31933886
15059947
26823016
15657432
19377875
17142325
15486045
21460222
23431142
11159838
27654866
19941816
14718389
34375550
18593598
17360704
23997214
24501773
16163708
10604992
15297577
17106060
24396487
25893857
20361349
16822962
12554776
18454177
29434871
34530870
16141331
12356731
19169277
20543098
17685427
21478906
18463290
16250012
20534535
21228323
7535768
26617336
15963258
10617652
17196532
19995915
10464310
15315965
12082540
21685939
25730857
18305109
25703330
16928771
15681433
11083859
16076871
20395206
23146907
26246800
21454539
12660819
21220474
15866871
15637081
19858202
34403210
18032526
16195541
21829454
16459330
17209045
12808105
11585739
16162500
25833830
18246127
11864968
24418169
15935618
19925796
20160123
17056593
14998784
18215133
10508618
18775330
18760948
12952943
21768338
17317777
8155326
22258404
15788397
26919095
28213521
21192818
33798093
15851026
26242183
12402043
21868357
17064352
20927383
16380505
15035987
21454675
18957207
19193766
21188622
19050043
16904111
19888469
26073130
20185553
15282551
16790523
23405013
11994288
17510392
32081857
18941537
20930115
19106095
11043579
21499301
20145126
24427291
10958690
15939799
19088846
19286657
18424438
15308678
18198175
27323814
24338688
24252946
19956644
21478903
12014987
23017243
17525129
12511559
17615152
16505244
20122898
12077249
17123942
26035354
11278407
15665049
20531297
17292825
14976148
16449644
16461767
23361053
19261611
11502744
25658205
12149254
30327409
17560175
24352879
26586479
26804906
25779944
34125833
19118012
11352917
16740725
11884401
16464862
16641227
27323830
18063582
22955283
24561529
10779765
10542198
16135812
23564461
17210721
24469048
24803537
21602434
17110601
21045017
11073973
10597231
23687376
34556812
17341659
18692468
17579083
12384403
21408150
25417160
11752053
23325789
17371847
11970985
22327338
26265441
16840783
17283152
26616862
23188829
17239630
21487005
11024037
17053147
24363437
25682201
20234004
12391272
23644655
25638159
20808799
17922836
20129247
24913355
18451171
25483104
26296889
21081844
17404396
11287604
18263590
26317416
15541367
16467309
12765939
16331263
16498402
20485667
11230338
16387841
19543320
7687743
20228268
15630487
16774943
16710359
10803464
16844778
16574647
15994317
17495961
21215800
17590453
26382850
19002495
12909616
20599567
12558965
10667594
24711455
17255109
16038803
12370087
21072043
20008839
18805968
10206983
11875080
20231899
21499296
21908610
16002410
12821943
24292678
17525735
17928416
21057531
25236495
17283137
21659545
24403530
16919488
23378338
22973961
18847491
16682955
20840866
16153436
23542175
24492000
12526087
26556867
12133965
12433918
20065107
14610044
11959800
15580310
21730285
11046056
9124279
14707024
26725216
16452220
22212957
25811962
15696170
11416124
20498373
17157787
21653826
16149052
20022946
34262144
16434970
10558990
18045996
10925301
16280323
25581518
15899879
21441955
20566643
15466476
15657177
11706017
15059847
8444886
18519681
23528009
33513601
20138986
12368275
24608435
17062641
20082306
20375017
17537990
24567333
33820494
10712263
21278199
19011679
20145145
27582276
25640183
21730054
16177091
17250586
15879307
16728403
18299328
24269888
17303383
9482941
17671177
17173941
24095720
15304500
12874275
33828192
11827968
33731431
10799542
15328343
18838481
19036157
17634226
17110082
17855349
31722981
26079947
25002506
14559232
23584478
18593910
17114467
16373398
16931794
17016429
14676826
28415597
12029087
24269383
8626767
20478260
12097262
14764579
12181310
15100319
12384432
15271996
17562849
19036927
19326083
20072652
25940440
11922392
17913704
19494114
25596730
18938240
27449290
12897059
21478911
21123455
26804170
10940302
16624816
26876209
12048182
17150968
21478863
17307705
18658095
24995980
16582879
17289590
33667549
17209041
17890097
21726627
27662093
16843264
19426503
11103941
11940578
17906618
26234813
19029090
15007386
15958730
12576312
17667937
17785202
34480897
20647329
18941890
16446383
25562429
10867021
26985018
16413470
23178720
25578563
34437586
21738699
21258408
20388777
24681954
20459645
12242309
15289328
21575862
16185843
19147767
34497368
19153083
12124352
17371994
17567959
15611080
17297454
23012246
14557270
28542650
15713673
21129803
19460345
10958798
21772273
21900206
19205871
17591920
19217381
12963813
19718025
24469056
16624867
21149447
15728578
33902596
11971971
16455819
19112174
10751321
1835084
11016927
18267069
20410276
21980390
17409387
23831578
21477078
15558056
|
PPP2CA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
12624094
12840032
18039929
16680151
16456541
10995457
18042541
18588945
|
MAPK3
|
SMAD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
17081983
16156666
19413330
11027280
9620846
33676893
23331499
8226933
20068231
18988627
12193595
18491316
18691976
8388392
19651622
10197981
18775330
19115199
9604935
15212693
|
MAPK3
|
GJA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
9535909
19664994
9535905
12637502
15605363
8631994
17570479
|
MAPK3
|
PLCB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11287604
11481231
|
MAPK3
|
STMN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
11718727
9525956
9126608
|
MAPK3
|
GATA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15967790
|
MAPK3
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
10949034
18372406
15461668
9528769
12118371
14680484
17615152
15059947
16076840
7491495
12093745
15212693
15528270
7838153
|
MAPK3
|
FGFR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
27342992
23405013
18411303
|
MAPK3
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
24342355
17290218
26036637
29233910
24484936
20937773
|
MAPK3
|
NOS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17804409
|
SUMO1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11960997
12032081
15199155
24068740
|
UBE2I
|
SUMO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
21212807
25416956
16713569
18691969
17938407
11735126
25502805
15931224
26496610
16732283
24352468
17353931
18359863
10666456
21174150
8921390
9353268
12924945
21949651
32296183
16524884
17956732
18264111
12764129
10961991
14673145
19684601
17698038
16494873
31515488
23871147
17491593
|
PIAS1
|
SUMO1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16524884
22578841
19217413
18806873
14609633
11583632
|
YY1
|
FOXA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
18533032
27062924
21151129
16009131
16087863
16980581
21934649
16113099
18358809
22056668
23172872
15282324
21878914
23192763
|
YY1
|
OPRM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17990281
19164126
19765550
|
HDAC2
|
YY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
9016636
19139378
11486036
8917507
|
POMC
|
OPRM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15464143
|
TFCP2
|
HBA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
2233727
20421208
18629613
8157699
9753426
10491335
|
ESR1
|
CRH
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
18597742
18404132
8408641
17947358
9408232
15126558
12161509
15564578
|
HSPB1
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
24.0
|
1.0
|
Omnipath
|
12897149
9047237
16439988
19324872
18266962
14761954
9169414
10694513
19011223
|
PTPN6
|
IFNG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
34.0
|
1.0
|
ACSN
|
10358138
11447289
11449354
11572860
12138178
12176909
1238444
12393695
12421919
12707331
12773515
12917349
15169881
15240681
15699106
15713798
16204085
19833085
20363967
20435894
21469115
22483603
22513334
22683124
22952938
22955274
25355530
26667266
26755705
27474009
8976179
8986721
9751747
9765283
|
PTPN6
|
IL2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
34.0
|
1.0
|
ACSN
|
10358138
11447289
11449354
11572860
12138178
12176909
1238444
12393695
12421919
12707331
12773515
12917349
15169881
15240681
15699106
15713798
16204085
19833085
20363967
20435894
21469115
22483603
22513334
22683124
22952938
22955274
25355530
26667266
26755705
27474009
8976179
8986721
9751747
9765283
|
PTPN6
|
CD79A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
7539038
|
PTPN6
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18086677
|
SMAD2
|
NOS2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
24.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
21042762
21614932
22331441
23390297
6357187
8871614
9389648
9670020
|
SMAD2
|
IFNG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
24.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
21042762
21614932
22331441
23390297
6357187
8871614
9389648
9670020
|
SMAD2
|
MEF2C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11160896
|
IL4
|
IFNG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
17.0
|
1.0
|
ACSN
|
10485906
10820262
11160275
11371360
11870632
12401408
12433365
12496409
12818165
18250477
1825141
20184663
20856220
21097505
23124025
2965306
9834059
|
FGFR1
|
BCAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11019781
12601080
|
UBE2I
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11960997
12032081
15199155
24068740
|
FOXA1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
18533032
27062924
21151129
16009131
16087863
16980581
21934649
16113099
18358809
22056668
23172872
15282324
21878914
23192763
|
HDAC1
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
HDAC2
|
â—¼ SHARES_COMPLEX
|
|
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ SHARES_COMPLEX
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ UP_REGULATES
|
✅
|
+
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
BMI1
|
â—¼ UP_REGULATES
|
✅
|
+
|
22.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
15151915
15155580
15465827
16232121
17055429
17508028
17550342
20027199
20713526
20818389
21234400
21733352
2191300
21919891
22370643
22796940
23140366
23869868
9618481
|
HDAC1
|
HDAC2
|
â—¼ UP_REGULATES
|
✅
|
+
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
21655924
23242655
18316616
20101232
|
UBE2I
|
HDAC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12820959
15340381
11960997
|
HDAC2
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
14673164
15465827
17018611
17563753
21234400
21577210
22514743
22796940
|
HDAC2
|
SIN3A
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
14673164
15465827
17018611
17563753
21234400
21577210
22514743
22796940
|
BMI1
|
RNF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
BMI1
|
RNF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
16710298
22493164
22902369
20068231
22325352
25355358
17157253
16751658
26496610
16714294
26468281
26151332
12183370
12589020
21772249
25843776
20601937
32296183
21676867
27647897
15563468
27705803
16359901
24457600
19636380
|
UBE2I
|
UBE3A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15340381
12820959
18997815
15668399
18298802
|
PIAS1
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15666801
11117529
|
MAPK8
|
APP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
12917434
14970211
24610780
20122754
15936948
|
ESR1
|
HSPB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15833836
10960840
11174852
8923463
|
ESR1
|
PRL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
3481434
9259323
7649480
18022314
2082192
10830306
|
SRF
|
ACTA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
18337547
12505862
17303098
19269978
19608972
20093628
15576380
12530967
20016221
24446247
22461426
14970199
15269336
|
RET
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
18669648
9312068
11062067
15911620
95141073
16153436
15755722
|
MAPK8
|
YWHAZ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
18985696
25862939
15696159
11956222
19788416
21081103
15071501
18559254
7890696
|
MAPK8
|
STMN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25869138
23893240
16618812
17570479
24589734
|
TFCP2
|
BDNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21765426
24105466
22848609
19217433
20410295
18075316
22677942
|
GATA1
|
HBB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
18586828
22164220
12556498
15358512
20564185
12556492
1559609
3243278
15833715
12379744
14695898
21220744
2461328
2911469
12193659
17196618
|
NFE2
|
HBB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
9478996
18308612
16287851
12582249
7918632
12000849
12379744
12031797
9558374
10891470
|
TFCP2
|
OPRM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21326195
23485395
18453338
20385708
19602036
|