Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
H2AX XRCC1 â—¼   COLOCALIZATION 2.0 0.8 intact 19851285 7542621
PLK1 SGO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18331714
PARP1 CUL4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
CUL4A CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
APLF PARP2 â—¼   ADP_RIBOSYLATION ✅ 2.0 0.8 intact 8201796 21812934
PARP1 CETN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
CETN2 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
CUL4B CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
RAD23B CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
RBX1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
XPA CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
PARP1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
XPC CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
DDB1 CHD1L â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
CHD1L DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 19661379
CHFR PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18172500 23268447
PARP1 CUL4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
PARP1 DDB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
XPC DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20368362
PARP1 DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
XRCC5 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20368362
HIST1H2BB HIST2H2BE â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
PARP1 RAD23B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
PARP1 RBX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
XPA PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0915085107 20304803
APLF CHD1L â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CBX1 CBX3 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CTCF PARP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 14759373 20038529 19450526
H2AX CETN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AX CTCF â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
H2AX PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L RFA2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19666485 19661379
RFA2 XRCC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 24332808
CHD1L TNKS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L HSP7C â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RBX1 HSP7C â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12481031 30349055
HSP7C PRKDC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22939629 27684187
TRI33 CBX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20603019 34079125
XPC SP16H â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TNKS2 RN146 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21799911 27521426
RN166 XRCC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
RN166 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
F196A CHD1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NCUG1 CHD1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LRRK2 CBX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 23075850
CCL22 CHD1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LAMP2 CHD1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LRRK2 CHD1L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 26496610
CHD1L XRCC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19666485 19661379
CHD1L PRKDC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 19666485 19661379
CHD1L XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L TNKS2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L HLTF â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XPC PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 PARP2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CHD1L H2AX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
H2AX XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20085707 21679440 18406329
RFA2 PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RFA2 XRCC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 26344197 10064605 24981860 24332808
RFA2 PARP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24332808
RFA2 XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 24981860
RN166 TNKS1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
LRRK2 HSP7C â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19826009 23455607 28320779 31046837 24947832 17400507 18367605 24510904 29519959
TNR6 CHD1L â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHD1L SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
RN146 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 21799911
XRCC6 SP16H â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30585729
RN146 CHD1L â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194 21799911
RN146 XRCC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21825151 21799911
RN146 CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 HLTF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21825151 26186194 21799911
RN146 XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN146 PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 21799911 21825151 26186194 28514442
RN166 CHD1L â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
RN166 TNKS2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHD1L APLF â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 23926104 26186194 28514442 19661379
APLF CETN2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHD1L PARP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19666485 28514442 33961781
XPC RAD23B â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 34591642
RPA1 XPA â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PARP2 RNF146 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CHD1L TRI33 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33053171 23926104
CHD1L RNF146 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PRKDC PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20085707 16794079 21575865 9398855
PARP1 DDB2 â—¼   KO_UP_REGULATES ✅ + 0.84 0.84 PKG 28854368
H2AFX SUPT16H â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
H2AX XRCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15613478 33961781 23145133 20224553 28514442 18406329
XPC XPA â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 17154534 12486030
H2AX PRKDC â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15613478 26095369 14627815 18406329 22184063 20085707 20356835
RN146 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 21825151 26186194 21799911
XRCC1 APLF â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 23178593 8412483
CBX3 XRCC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21888893 34079125
LRRK2 DDB1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 31046837 24725412
XPC H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 28242625 19805520
PARP2 APLF â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 21812934 26186194
CBX3 CBX5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
XPC PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125 28760956
XRCC6 XRCC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 30585729
APLF PARP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CHFR PARP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
DDB2 RBX1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CHD1L PARP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHD1L XRCC6 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
PARP2 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12217960 11948190 19629035
APLF XRCC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
DDB2 XPC â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
H2AFX PRKDC â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RPA1 XRCC6 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CUL4B DDB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
H2AFX PARP1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
H2AX PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28796254 28242625 16377563 27728808 18406329 28514442 20000738 20085707 16522924
CUL4B HSP7C â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 28225217 23238014 21145461
PARP1 APLF â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26186194 17396150 18172500 20098424 28514442 27067600
PRKDC RPA2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
H2AFX XRCC6 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
POLB XRCC1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
XPA RFA2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10982866 33961781 12527904 7876167 20670893 32296183 19996105 11081631 9535929 20304803 7565690 8972858
PRKDC RFA2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10713094 8943020 24332808 16540648 11731442 10064605 9295339
RN146 TNKS1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21799911 25327252 29604130 32698014
XRCC5 APLF â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17396150 20098424 26186194 23178593 28514442
CBX5 CBX3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 15306854 17314413 34079125 20562864 11336697 16713569 19498464 27705803 21888893 20231385 20850016
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 28446751 34026424 29499938 22038470 19250909 26496610 31973889 12481031 30349055 24292684 30945288 33969670 27113764 32140073 33504946 12609982 25189618 23238014
XRCC1 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24778456 18971944 12897160 15555565 30260704 34079125 14500814 16713569 9584196 20302655 34111398 15044383 20303835
XRCC5 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26496610 22404984 15520013 21679440 26446488 26344197 17308091 15941674 28154079 16857680 20711232 19303849 20023628 15758953 20085707 10750018 10446239 33005030 9312071 28345663 12393188
XRCC6 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8422676 20711232 19303849 26175416 28345663 30585729 17308091 22939629 26496610 10750018 15941674 33005030 21969602 15520013 10064605 21575865 26446488
TNKS2 RNF146 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21799911 21478859 21383061
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22939629 15367688 26496610 26774286 21172662 11196700 15520013 22863883 21679440 17159921 30021884 14681455 26446488 26344197 10207052 30585729 17308091 11493912 10757784 10219089 10984620 19118032 12145306 32296183 28035050 19177010 18809223 21454661 15910003 10783163 28514442 21070772 25574025 15023334 7699019 10750018 10446239 22451927 33005030 9488450 17283121 19906305
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
RPA2 RPA3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
H2AX SP16H â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 24981860 28242625 28514442 18406329 16522924
RPA3 RPA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24126761
CUL4A DDB2 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
XRCC5 XRCC6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
BPTF CHD1L â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
POLB ID1 â—¼   KO_UP_REGULATES ✅ + 0.94 0.94 PKG 28854368
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
APLF XRCC6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
APLF XRCC5 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CETN2 XPC â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
RAD23B XPC â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PRKDC XRCC5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
RPA1 RPA3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPA1 RPA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PARP1 POLB â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP2 POLB â—¼   PHYSICAL_INTERACTION 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
XRCC1 POLB â—¼   PHYSICAL_INTERACTION 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
POLB RPA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB RPA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLB RPA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
PARP2 POLB â—¼   SHARES_COMPLEX 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
PARP1 POLB â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
XRCC1 POLB â—¼   SHARES_COMPLEX 65.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
XRCC1 POLB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 15107487 26186194 8978692 16442856 15520167 11467963 26496610 15367657 25423885 16713569
XRCC5 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
PRKDC H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 107.0 1.0 Omnipath 18454178 9488723 19321613 21930799 19305155 25487737 22819196 20493860 17570479 12607005 16673875 26976643 17723002 21151168 16039583 21514376 26438602 19049966 20368801 23916969 16935931 27919340 17923115 16061642 18438399 20157519 20461094 21690091 24253929 19531483 26960975 25168287 18758438 19268590 27813335 25690891 17210576 26748709 18406329 23972723 17412408 34429760 27551505 12692309 29221122 20703100 16861886 25070753 27332952 33691101 33863809 23653357 21283714 16788066 19781914 20205745 20860841 21389100 16148027 20116089 15610743 20192759 20224553 14627815 24893124 10734083 20488183 23185622 18157161 33945602 30573684 12766154 25699710 18755145 27738310 10477747 34504648 16820894 20356835 19014481 20713529 17525342 23671119 26114388 23355489 28790110 23678292 20118229 23166506 33986864 15604242 16377563 20609246 12907603 26119999 25072018 15289343 23891091 25269479 23620287 33731502 22972376 34282773 26578593
RPA3 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
XPA CUL4A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
APLF PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18172500 17396150 20098424
XPC CETN2 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11900249 12648680 15703371 16697054 17884153 18199748 19809470 19847258 20211143 20457011 22615860
XPA CETN2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
XPC CETN2 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11900249 12648680 15703371 16697054 17884153 18199748 19809470 19847258 20211143 20457011 22615860
PARP1 CHD1L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22146311 19666485
CHFR PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 34140642 17442268 16647857
RPA1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA2 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA CUL4B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RPA2 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA1 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA DDB1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
RBX1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
XPA DDB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RBX1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15882621 22039351 19740755 29604309 23319653
PARP1 H2AFX â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12607003 14726013 15175241 15459660 15703371 16581787 16697054 17088286 17116881 17303408 17713585 19208614 19364882 19772495 19847258 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9488723
PARP1 XPA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
PARP1 XRCC1 â—¼   PHYSICAL_INTERACTION 70.0 1.0 ACSN 10858306 11163244 11283614 11900249 11948190 12032095 12202749 12637553 12648680 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19748837 19809470 19847258 20027199 20056333 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 PARP2 â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 18835851 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21037379 21060331 21076181 21270334 21337561 21376743 21818122 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
PARP1 XRCC1 â—¼   SHARES_COMPLEX 70.0 1.0 ACSN 10858306 11163244 11283614 11900249 11948190 12032095 12202749 12637553 12648680 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19748837 19809470 19847258 20027199 20056333 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 XRCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9592149 18971944 15555565 19643912 15044383 14500814 16713569 24778456 12897160 20303835 20302655 9584196
PARP1 SUPT16H â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18406329 16682447
XRCC1 PARP2 â—¼   PHYSICAL_INTERACTION 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
XRCC1 PARP2 â—¼   SHARES_COMPLEX 54.0 1.0 ACSN 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 8264637 8978692
PRKDC RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 26811421 9139719 9295339 21300785 28046023 27999209 23684611 19704001 24332808 18289945 15703371 21558276 21731742 20016603 19473888 24819595 21175350 8760901 33826602 19843584 32989256 24830725 19808869 20154705 17570479 25733714 33636182 18669648 23677613 21376743 14872059 22057367 24639502 17035231 31527085 30030458 20691907 17928296 21107010 22977173 11731442 15060176 23319600 19772495 19847258 26166705 29875999 28506294 10064605 34385259 16731533 33357448 19346677 16697054 8943020
XPA RAD23B â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RPA1 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RPA3 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
XPA RBX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 11278856 23038248 18614043 25154395 14517266 19056823 20368362
RPA2 RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RNF146 TNKS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 19759537 21478859 21799911 22274711
RNF146 TNKS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21478859 21799911 19759537 22274711
RPA2 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
XPA RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12527904 19446504 7665601 8972858 7876167 20304803 7565690 9535929
RPA2 XPA â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 7533895
RPA2 XRCC1 â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RPA2 RPA3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 XPA â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 7533895
RPA2 RPA3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 XRCC1 â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RPA2 RPA3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
XPA RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 12527904 19996105 10982866 8972858 20304803 7876167 11081631 7565690 32296183 20670893 9535929
PARP1 CHFR â—¼   KO_UP_REGULATES ✅ + 1.19 1.19 PKG 28854368
DDB2 ID1 â—¼   KO_DOWN_REGULATES ✅ - -1.7 1.69 PKG 28854368
POLB CHD1L â—¼   KO_DOWN_REGULATES ✅ - -2.33 2.32 PKG 28854368
CBX1 CBX1 â—¼   KO_DOWN_REGULATES ✅ - -2.99 2.98 PKG 28854368
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
DDB2 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -5.71 5.7 PKG 28854368
PARP2 PARP2 â—¼   KO_DOWN_REGULATES ✅ - -6.68 6.67 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368