Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
NFE2L2 CUL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21793854 20452971
DAZAP2 RNF115 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
SUMO1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25704882 22493095
RNF11 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8012720 20676133
SUMO1 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
SUMO1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393906 11384992
UBA1 OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF11 OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21130715
RNF11 RNF10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF14 RNF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF11 RNF168 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
UBE2E2 RNF125 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611551104 17460044
RNF8 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20385750
UBE2E1 RNF5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
RNF8 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
UBE2E2 TRIM39 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 8153045 21516116
TRIM39 UBE2E2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
UBA1 WWP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2V1 UBE2N â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213148 11057907
UBE2N UBE2V1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
MDC1 MDM2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 18471438 14578343
MDC1 RNF10 â—¼   KO_DOWN_REGULATES ✅ - -0.83 0.82 PKG 28854368
RNF4 UBE2N â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
BARD1 MDC1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12611903 29656893
CBL ITCH â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
RNF11 WWP2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28292929 15231748 32814053 31985874 16713569 16189514
UBA1 UBE2E2 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
UBE2N ZNRF2 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2E2 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2E1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2N â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
TRIM32 UBE2E1 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
BARD1 UBA1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12431996 12438698 11278247 15184379 12485996 11927591 12887909
PARK2 UBE2E2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
TRIM23 UBE2E1 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
MDC1 UBE2E2 â—¼   KO_DOWN_REGULATES ✅ - -0.87 0.86 PKG 28854368
CHFR DTX3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 22493164 26186194
DET1 DDA1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 19295130 17452440
SUMO1 MDM2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 18583933 20972456 15876874 21316347 11384992 12393906 12297306 12917636 22411991 15876864 17000718
UBE2E2 MID1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8153045 21516116
SRPK1 SRPK2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 21157427 32707033
TRIM2 TRIM3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 32296183
RLIM UBE2E2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
STUB1 UBE2V1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MID1 MID2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
BRCA1 UBA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12438698 26831064 11278247 15184379 12485996 11927591 12887909 14638690
RING1 RNF2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PARK2 UBE2N â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MDC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 17525332 15569676 29656893 12607005 19766185 12611903
HDAC2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
BRCA1 SUMO1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
UBE2N RNF8 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22589545 31048496 20023648 16215985 22814251 23255131 28244869 25909880 19549727 21706008 26285145 18678647 24732096 31792955 27909234 21911360 29523790
UBE2E1 ARIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
UBE2N ARIH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
BRCA1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15520196
UBE2N HERC5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
RNF8 MDC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24240613 25512560 18001825 26734725 18001824 18006705 28943310
TRIM28 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16107876
SUMO1 RNF4 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24844634 23086935 29180619 32296183 15707587 24151981 24907272
RNF4 SUMO1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RNF8 UBE2N â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
RING1 PCGF2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 24981860
UBE2N UBA1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 27173435 14517261 29537486 18678647 30097011 27182664 25527291 33619271 31638574
UBA1 UBE2E1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
PCGF2 RING1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
MDC1 HERC5 â—¼   KO_UP_REGULATES ✅ + 0.91 0.91 PKG 28854368
RNF115 UBE2E2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
TRIM50 UBE2E2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
UBA1 UBE2N â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
ARRDC3 UBE2E2 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
PCGF2 RNF2 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
RNF2 PCGF2 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 24981860
RNF5 UBE2E2 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
UBE2N UBE2V1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
UBE2N ZNRF1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RNF8 DDA1 â—¼   KO_DOWN_REGULATES ✅ - -0.97 0.96 PKG 28854368
OTUB1 UBE2N â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
STUB1 UBE2N â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
BARD1 BRCA1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BRCA1 BARD1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 BARD1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BARD1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 99.0 1.0 Omnipath 16403807 16391231 28262780 15159397 25652403 26350354 26490435 14647430 11927591 25184681 16713569 11526114 35203293 9738006 12732733 24289923 11573085 18936166 23086937 24085845 12890688 15855157 24695549 19369211 9798686 11257228 11498787 12700228 11925436 10477523 19176389 23680151 25634209 23416467 34726323 29355525 18369654 14636569 11504724 12951069 19117993 20060929 17873885 14638690 18493658 11278247 15184379 22110403 11301010 11773071 12431996 10635334 20029420 9788437 17664283 21901007 25252691 12485996 10026184 12438698 17525341 16489000 8944023 15265711 12419249 20681793 9342365 27239795 20215511 25823446 19916563
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
CUL3 NFE2L2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
RNF11 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14559117 19131965
MDC1 RNF8 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 RNF8 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 RNF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 24240613 18001824 25512560 18001825 18678647 18082599 18006705
OTUB1 UBE2N â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22367539 21130715 24145445 21763684 35500217
RNF8 UBE2N â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20023648 21911360 22589545 25909880 16215985 24732096 18678647 26285145 23255131 22814251 19549727
UBE2N UBE2V1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 15492226 29662619 10089880 1551980 11057907 16129784 25260751 15147900 22367539 18082144 18678647 26101372 20551964 16307917 17709375 19549727 18029035 21460221 24145445 16215985 20613989 25548215
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
PRIMPOL UBE2E2 â—¼   KO_DOWN_REGULATES ✅ - -4.56 4.55 PKG 28854368