Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
BAG3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
DVL2 CLTC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17199046 12958364
UBE2K DTX3L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16204234
FLNC GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
DVL2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRB2 RPS13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RPS8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HNRNPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 IQGAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SVIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 FLNB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EEF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RPL7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RPL4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SPEN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 TUFM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SLC25A3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARPC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRB2 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HNRNPH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RPL12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SPTBN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
SPRED1 KAT2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT2B RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10747963
CHFR PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18172500 23268447
UBE2L3 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24979766 26216882
PSEN2 PSEN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221852 9437013
PSEN1 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22330899 22363130
PSEN1 DLL1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22330899 22363130
PSEN1 JAG1 â—¼   UP_REGULATES ✅ 2.0 0.8 ACSN 22330899 22363130
APH1B PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12522139 12471034
PSEN1 DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12794186
SPRED1 SNW1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNW1 RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPRED1 RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPRED1 DTX3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TP53 TRAF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12788948 16969126
TP53 MAML1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24473123 17317671
TP53 DLST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17916908 21191025
TP53 TRAF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12788948
UBE2V1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
XIAP RAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22117219 8313544
UBE2D1 DTX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TRAF4 FAM90A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
DVL2 FAM90A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
FAM90A1 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
NOTCH1 HEYL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20951801 11044625
DVL2 YES1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
FLNA PSEN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221852 9437013
NOTCH1 DTX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14567914 15965470
ITCH DTX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17028573 5219205
ITCH DTX1 â—¼   COLOCALIZATION 2.0 0.8 intact 17028573 5219205
NOTCH1 DLL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 20351093 22363487
NOTCH1 ITCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8313469 19567869
NOTCH1 DLL1 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 20351093 22363487
NOTCH1 NRARP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11783997 15325262
NOTCH1 LFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15207708 22298955
NOTCH1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330899 22363130
NOTCH1 HEY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21828089 14976548
CIR1 HDAC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6548441 9874765
HDAC1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9694793
CIR1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548441 9874765
HDAC2 CIR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 14673164 22796940
HDAC2 CIR1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 14673164 22796940
HES1 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23037857 22172337
HES1 TLE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19250647 16608701
HES1 MAML1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22529374 21640102
RBPJ HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19866488 10520600
HES1 TLE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24270405 8687460
NCSTN APH1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
APH1A APH1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16252010 16630834
APH1A APH1B â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 16252010 16630834
NCOR2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12589049 10612426
NUMBL ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16508312
UBE2E3 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SPEN ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN1 NUMBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
NCOR2 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16287852 23331499
NOTCH2 MAML3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
NOTCH2 MAML1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
NOTCH2 MAML2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
RBPJ NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9032325 19147558
DLL4 NOTCH3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19208840 15533827
DTX4 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10531053 23331499
RBPJ NRARP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11783997 15325262
RBPJ CIR1 â—¼   COLOCALIZATION 2.0 0.8 intact 6548441 9874765
PFN2 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PSENEN NCSTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
NCSTN PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10993067
RBPJ MAML3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
RBPJ MAML3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21873209 12370315
FLNB UBE2L6 â—¼   COLOCALIZATION 2.0 0.8 intact 19270716 7288582
RBPJ HEY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21828089 14976548
SPEN RBPJ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21102556 8094313
RBPJ MAML2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
RBPJ MAML2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21873209 12370315
CHFR UBE2D2 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
FAM90A1 SPRED1 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
NRARP RBPJ â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
EP300 PARP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18280497 16204234 19622798 12960163 24636898 33742100
NOTCH1 NRARP â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
KAT2B KAT2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10373431 24981860
DTX3 GUAD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DTX3 NDUS6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
DTX3 SYFB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
PRKDC MK09 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11749722 22366412
DTX3 NMD3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
DTX3 ITSN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TLE3 TLE2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 24981860
DTX3 RN114 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
DTX3 NARFL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
DTX3 NDUF5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 33403043
NOTCH1 SNW1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EP300 RAN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12649209 33742100
GRB2 MK09 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7642542 9019171
PRKDC PARP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16794079 9398855 21575865 20085707
HES1 TLE2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9874198
TRIM21 UBE2D2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
NCSTN PSEN2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
HES1 TLE1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CIR1 SNW1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
DTX1 NOTCH1 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
EP300 PRKDC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
GRB2 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17474147 12577067 21706016
PARP1 HDAC2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 16204234 20596014
HEY2 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 11486045
HEY2 HEY1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 27129302 33961781 26186194 24366871 19802006
NCOR2 HDAC2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 30737378 16481466 11013263
TP53 UBE2D1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
TLE1 TLE4 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
PARP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 16204234 20596014 19470756
SVIL FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20309963 26496610
HEY1 HES1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 27129302 26068074 19802006 33961781
FLNB FLNC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22863883 19293945
CTBP1 KAT2B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15834423 9824164 16122695
CHFR DTX3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 22493164 33961781 26186194
DTX3 MK09 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 26186194
UBE2D1 XIAP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
NMD3 RPL7 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ITCH UBE2D3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
NMD3 RPL4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CHFR PARP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
NUMB TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
FLNA FLNB â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HDAC2 SNW1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10644367 20467437 30737378
DVL3 SNW1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781
RBPJ NOTCH1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 8176976 21475249
RBPJ MAML1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 8176976 21475249
NOTCH4 MAML2 â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 12386158
UBE2D2 XIAP â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTBP1 CTBP2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
NOTCH2 RBPJ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PRKDC TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CREBBP KAT2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
NOTCH4 MAML3 â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 12370315
NOTCH3 RBPJ â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
DVL2 BAG3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31340145 16189514 16713569 21516116
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
SNW1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14985122 10713164 11509665 10644367 20467437
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
HDAC1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11739383 16481466 11013263
HDAC2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17967884 31041561 16713569 28947780 16036112 10766745 18212045 11022042
DVL2 DVL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 31340145 33961781 28514442
ITCH NUMB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20818436 12682059 18628966
CTBP2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31041561 16189514 25416956 16713569 21988832 28947780 30585266 26496610 33961781 35016035 26186194 24722188 27107012 9858600 26344197
TLE2 TLE1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 9874198 33961781 24981860
UBE2D2 UBE2K â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
MAML1 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15546612 12050117 12391150
KAT2A KAT2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
PARP1 XRCC5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24140708 16490787 21575865 16794079 14734561 21679440 34079125 10400681 17283121 20085707
XRCC5 PRKDC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15941674 10750018 20023628 17308091 15758953 20085707 33005030 10446239 26496610 19303849 20711232 9312071 26446488 15520013 28154079 28345663 16857680 12393188 22404984 21679440 26344197
TP53 RBPJ â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 19836055 24254977 26302407
TP53 RBPJ â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 19836055 24254977 26302407
TP53 JAG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
XIAP TLE2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14685266 19590513 22304967
XIAP TLE4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14685266 19590513 22304967
XIAP TLE3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14685266 19590513 22304967
XIAP TLE1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14685266 19590513 22304967
NOTCH1 DTX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10933396 9881968 15356142
HES1 DTX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20161710 20208568 16990763
ITCH DTX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17028573
NOTCH1 HES5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11741889 10520600 10205173
CTBP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 9650586 16189514 23752268 31041561 16713569 28947780 10995736 34147029 18765668 11022042
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
TLE4 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8649374 8001118 8687460
TLE3 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8649374 8001118 8687460
TLE1 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8649374 8001118 8687460
TLE2 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8649374 8001118 8687460
ADAM17 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
APH1B PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12297508
APH1B NCSTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857757 12297508
UBE2E1 ATXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18439907 25641559
UBE2L6 UBE2E1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
ITSN1 UBE2K â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MFNG DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12036964
UBE2L6 FLNB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19270716 12582176 16009940
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ITCH UBE2D2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
TLE1 HDAC1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 19101520 22439931
PSEN2 PSENEN â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
KAT2B TP53 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
HNRNPA1 HNRNPH1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
JAG1 NOTCH1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
TLE1 HES1 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 18611861 24270405 19321451 8687460 33961781 19956621
TRIM21 UBE2E1 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
RNF38 UBE2D2 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
ITCH DTX1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 17028573 18628966
NOTCH1 MAML1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 23022380
DVL1 DVL3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
NMD3 RPL7A â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
FLOT2 SVIL â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
PSENEN PSEN1 â—¼   CLEAVAGE ✅ + 0.96 0.96 Signor 12522139
ITCH UBE2L3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
FLNB FLNA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22939629 26344197 12393796 26496610
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
MAML1 RBPJ â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
PRKDC XRCC5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PSEN1 PSENEN â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
APH1A PSEN1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
APH1A PSENEN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
APH1A NCSTN â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
NCSTN PSENEN â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
EEF2 RPS8 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
EEF2 RPS13 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
EEF2 GNB2L1 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
GNB2L1 RPS13 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
NCSTN PSEN1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPL4 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
GNB2L1 RPL4 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPL7A â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPL7 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
EEF2 RPL12 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
GNB2L1 RPS8 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
GNB2L1 RPL12 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MAML1 NOTCH1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
NOTCH1 RBPJ â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
GNB2L1 RPL7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2L1 RPL7A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPL7 RPS13 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RPL12 RPL4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL4 RPL7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL4 RPS13 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL4 RPS8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL4 RPL7A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL12 RPS8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL12 RPS13 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL12 RPL7A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL12 RPL7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL7 RPS8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL7 RPL7A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL7A RPS13 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RPL7A RPS8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPS13 RPS8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
MAML1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19304754 16530044 12391150 12050117
DTX1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11564735
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
TP53 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9266967 20094059 15153330 17611664 18945670 14614455 17293853
KAT2B NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10747963 22120716 14500836 16713569 23029358
KAT2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19680552 11804596 12068014 16537920 9891054 10490106 14614455 20589832 19788416 12660246 12501250 16959611 19407812 9744860 15965232 16678111 17977830 17189186
KAT2B CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9687573 8684459 9687513 9445475 11864601 9267036 17496784
PARP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9312059 17891139 15044383 12898523 14627987 16713569 9565608
PRKDC HNRNPU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 27303920 25986610 19351595 25030905 19844162
PRKDC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 15355354 19398950 15254178 9372954 11483158 7862459 16713569 11875057 11551930 11883897 12548019 25168287 8502477 11709713 10446957 28145533 22726545 24886358 16552184 12242661 17570479 10196661 10747897 9885574 10673501 12091386 22355272 9765199 15489221 9561848 10801407 22504299 22444248 15177184 11042698 10358069 10470151 10606744 9744860 16397295 12959929 12064478 27130668 10951572 12111733 25937999 15381073 28102346 9363941 19918261
NOTCH1 PSEN1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
PSEN1 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
PSENEN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12522139 12198112 15322109 16189514 21115843 12639958
NCSTN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 12603837 23331499 21071413 14572442 12471034 10993067 18201567 18988627 12032140
MAPK9 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18667537
APH1A PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12522139 12471034 16189514 12297508
PSEN1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11518718
PSEN1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10593990 10077672 16713569 10206645 12374741
NCOR2 SNW1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17145710 11509665 23331499 14985122 10713164 10644367 20467437
NOTCH1 SNW1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 23331499 10713164 11404076 15546612
SNW1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 23331499 10713164 10644367
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
UBE2D1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
MAPK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 12356735 14665630 26158765 18778462 12969974 12861053 15254178 17135248 18669630 12384533 17363488 17698850 11283254 10706102 21454683 18931691 11551930 11397945 14612532 15064747 15963507 11175334 11423984 27147566 29234486 24657168 10581258 14517211 17353187 10673500 22030623 14527925 22728651 17525747 15629715 9393873 11447225 15671037 22285752 17245430 15140942 28673515 23871434 11078726 20041275 11896587 16731759 17121812 33514736 11861384 25431954 12810724 17967874 12955074 21832239 16818520 12756247 23798621 11526498 20009884 16713569 10202145 11850826 11896572 10710310 10570149 12959929 15269203 11583595 21148320
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
NUMB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23881403 18172499 18492217
NOTCH1 HEY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11486044 11095750 11486045 12814948 20007915 11971902 11741889
RBPJ HEY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11486044 11095750 11486045 17685488 12814948 11971902 11741889
DTX1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11153911 20208568 23331499 21071413 11226752 11564735 22162134 18988627
NOTCH1 NUMB â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 NUMB â—¼   PROTEIN_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
ADAM17 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
NOTCH1 NUMB â—¼   DOWN_REGULATES ✅ - 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   LOCALISATION ✅ 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
RBPJ NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22143792 11404076 12700242 24113181
NOTCH1 HEY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11486044 11486045 10964718 12814948 14739937 20007915 11971902 21956839
NOTCH1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10520600 11120788 10066785 16869730 12814948 7566092 21956839 9819428 10933396 11866432 20007915 10205173 11741889 19165418 15546612
NOTCH1 PSEN2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
DLL3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 29910816 16921404 16140393 18676613 10958687 22353464
DLL1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17537801 11006133 9819428 21685328 1006133 16140393 98194281 22353464
PSEN2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
NUMB NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12682059 15358736 16713569 8755477
MAML3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23022380 23331499 12370315
MAML2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12370315
LFNG NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10935626 16713569 12486116
DLL4 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 10837024 23331499 15137944 19494260 16140393 18988627 16713569 16219802 11739188 22353464
ADAM17 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10882063 19726682 19704010 19601831 9620803
ITCH NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12682059 10940313 23331499 16713569
NUMBL NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9169836
MFNG NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16713569 10935626 12486116
MAML1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 23022380 16530044 11101851 19907488 22100894 21820430 12644465 16713569 12370315 11997524 18427106 11390662
JAG2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23331499 21071413 16921404 11006133 1100613311006130 22503540 16713569 10958687 18988627 9315665 21352254 22353464
JAG1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18495817 16921404 15137944 769772111006133 16713569 23331499 21071413 23086448 22363130 18988627 21820430 18292500 18660822 22330899 17537801 11006133 7697721 10958687 22353464
NOTCH1 HES5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17537801 16283144
NOTCH1 HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23343194 19000719 18495817 16039586 19619488 17143292
NOTCH1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 51.0 1.0 Omnipath 23022380 16530044 22143792 25609649 26033182 16530045 21475249 8749394 23103515 16713569 22325781 19907488 23331499 21071413 26496610 18988627 22100894 10637481 26186194 21820430 12644465 10713164 17636029 9032325 12370315 11997524 11390662 19165418 19800882 20028974 30967258 9111040 17284587 17526737
NOTCH1 LFNG â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 10734111 16385447 9187150 10935637 9207795
JAG1 NUMB â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
JAG1 NUMB â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
JAG1 NUMB â—¼   DOWN_REGULATES ✅ - 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
MFNG JAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12036964 23331499 15574878
JAG1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 23331499 18660822 22330899 21071413 16921404 18988627 10958687 22363130 10551863 22353464
JAG1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22330899 16921404 11006133 14714274 22363130 18660822 12482954 22353464
JAG1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 29910816 22330899 22363130 24563863 22353464
TLE3 HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10485845 11266540 10559189 20405012
TLE2 HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10485845 11266540 10559189 20405012
TLE4 HDAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10485845 11266540 10559189 20405012
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
RBPJ HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10520600 11120788 21311046 10066785 17611704 12814948 9819428 10933396 11866432 10205173 7566092 22718343
ATP5A1 ATP5B â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 10838049 11410595 11744738 12110673 14701807 14757859 18953340 22841746
ATP5A1 ATP5B â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 10838049 11410595 11744738 12110673 14701807 14757859 18953340 22841746
NCSTN APH1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15189355 21071413 14572442 12471034 12857757 18201567 12297508
APH1A PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12471034 16189514 12297508
APH1A PSENEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12522139 15322109 12740439 16189514
NUMB ITCH â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 10940313 11318614 16469705 16861923 17115028 17312394 18552861 18628966 20818436 20940030 21107885 21383157
NUMB ITCH â—¼   PROTEIN_INTERACTION 12.0 1.0 ACSN 10940313 11318614 16469705 16861923 17115028 17312394 18552861 18628966 20818436 20940030 21107885 21383157
NUMB DLL1 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 19567869 20940030 21841793 22330899 22363130
NUMB ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12682059 23331499 20818436 18628966
ADAM17 DLL1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
RBPJ NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 11509665 23331499 18391971 9694793 10713164 21475249 11404076
NCOR2 SPEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11331609 15604093 24268649 16713569
PSEN2 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
DLL3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 29910816 11823422 16921404 22353464
LFNG NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11346656
MAML1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11101851
PSEN2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
MFNG NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11346656
DLL1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21685328 10958687 22353464 23111325 9244302
MAML3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315
JAG2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 21071413 16921404 16713569 10958687 18988627 22353464
MAML2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12370315
DLL4 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 30181175 15137944 19494260 22842086 30289388 22353464
NOTCH2 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25609649 26186194 23331499 26496610 9032325 12370315 11518718
PSEN2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
JAG2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23331499 21071413 16921404 11006133 1100613311006130 16713569 10958687 18988627 22353464
DLL4 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29910816 18182388 15137944 19494260 29230914 22353464
DLL1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 21685328 11006133 12482954 22353464
DLL3 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921404 29910816 22353464
MAML3 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 12370315
MAML2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12370315
MAML1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11101851
NOTCH3 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315 11518718 11404076
MAML1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11101851 11585921
MAML1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23022380 16530044 25609649 26186194 11101851 17145710 16921404 12644465 21475249 26496610 11997524
RBPJ CIR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 9874765 19165418
DLL1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29910816 22353464
TLE1 TLE3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10485845 11934263 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
PSEN2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
JAG2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 29910816 22353464
MAML3 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315
RBPJ HEY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11486044 11486045 10964718 12814948 14739937 11971902
TLE3 TLE4 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10485845 11934263 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
SPEN RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 16713569 12594956 12374742
NOTCH4 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 12370315 11518718 14701863
MAML2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12370315
DLL4 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 1621980212814940 12814948 10837027 16219802 18988627 22353464
DLL3 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921404 29910816 22353464