TLE1
|
POLB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
POLB
|
WFS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PCNA
|
EEF1A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7995081
20849852
|
COQ8A
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CASP6
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CASP6
|
SNCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CCDC90B
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
CCDC90B
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
RNF10
|
CLSTN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
COL4A5
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
GRB2
|
EEF1A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
EEF1A1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
GRB2
|
HSP90AB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
HIP1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RIF1
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
HSPB1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HSPB1
|
UBE2Q2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HSPB1
|
UBE2E3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SETDB1
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
RNF10
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
TERF1
|
KDM1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
23455924
8417751
|
UBE2I
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20023648
22508508
|
UBE2I
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12393906
20972456
|
RNF10
|
MEOX2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16335786
|
RAD18
|
TARDBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SPRED1
|
RAN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RNF10
|
RAN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RAN
|
SNCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RIF1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
SPRED1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
TLE1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
UTP14A
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
RNF11
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
WFS1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SETDB1
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
RNF10
|
TRIM55
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
31391242
233395
|
RNF10
|
TARDBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
UBE2D2
|
RNF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
UBE2D4
|
RNF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
RNF11
|
TLE1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RNF11
|
UBE2E3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SETDB1
|
TARDBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
UBE2V1
|
TARDBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
UTP14A
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
UBE2E3
|
TRIM55
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
31391242
233395
|
WFS1
|
UBE2E3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RAN
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
RNF11
|
UB2D2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
14562029
32296183
15231748
19549727
19690564
|
UB2D1
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
23150668
27106262
12646252
23671280
22124327
20124408
19240029
31796886
25624478
31337857
20694676
17848574
30244831
25543083
12690203
22916255
15013777
19247369
17301054
22331460
27903893
28362432
17170710
19965871
24980433
19032150
30017913
15280377
21157430
25888903
19597489
15242646
14671306
19805293
18632619
20173098
21887275
15001357
9450543
|
RNF10
|
UB2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19549727
33961781
|
RNF11
|
UB2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19690564
14562029
32296183
19549727
|
UBTD1
|
UB2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
32296183
24211586
|
UB2D3
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19549727
33961781
|
RNF10
|
UB2D4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19549727
33961781
|
TRI26
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
22493164
|
MDC1
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
18471438
14578343
|
MDC1
|
RNF10
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.83
|
0.82
|
PKG
|
28854368
|
UBE2D1
|
UBTD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.82
|
0.82
|
HuRI
|
32296183
|
TULP3
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
33961781
28514442
33187986
|
GRB2
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
31980649
12577067
|
RAD18
|
PCNA
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.86
|
0.86
|
Signor
|
19706603
|
RNF11
|
UB2D3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
19690564
28292929
14562029
19549727
|
MDC1
|
UBE2E2
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-0.87
|
0.86
|
PKG
|
28854368
|
UBTD1
|
UB2D2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33961781
32296183
24211586
|
UB2D2
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
23652204
15950904
22902369
23695783
19372219
21084285
21965653
19219073
11724934
23871895
17159902
11713287
29269425
20874444
14517261
10722742
34408321
27249653
22301280
18665269
29057323
22157679
14769800
24980433
32350255
30017913
15280377
20705607
24127580
24567357
19619542
26025930
19816404
22989009
18632619
16338390
17349959
10562557
28553961
18451149
|
UBTD1
|
UB2D3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
30804013
32296183
24211586
32483419
|
RNF10
|
UB2E3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
19549727
28514442
33961781
|
PCNA
|
UBE2I
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
UB2D2
|
RNF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
33961781
29643511
19549727
26186194
28514442
|
HSP90AA1
|
HSP90AB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.88
|
STRING
|
36370105
|
RAD18
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21967848
28924044
21227930
20675655
32701997
21858012
20064529
28831681
33508099
17108083
18363965
23345618
26170230
17720710
24958773
15359278
31873223
18245774
30700555
31887036
30563767
20600238
22904075
31160570
27377895
|
EEF1A1
|
SNCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
MEOX2
|
SPRED1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HuRI
|
32296183
|
MEOX2
|
UBE2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HuRI
|
32296183
|
MDM2
|
UBE2D3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.91
|
STRING
|
36370105
|
RNF11
|
UBE2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.93
|
0.93
|
HuRI
|
32296183
|
UBE2D4
|
UBTD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.93
|
0.93
|
HuRI
|
32296183
|
RNF11
|
UBE2D4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.94
|
0.94
|
HuRI
|
32296183
|
RAD18
|
RNF10
|
â—¼ KO_UP_REGULATES
|
✅
|
+
|
0.97
|
0.97
|
PKG
|
28854368
|
MDM2
|
UBE2D2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
PCNA
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
MDM2
|
UBE2D1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
PCNA
|
POLB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
40.0
|
1.0
|
ACSN
|
10858306
11756412
11948190
12637553
14624239
14726013
15703371
16442856
16697054
17088286
17116881
18087292
18584027
18809224
19208614
19364882
1974050
19748837
19772495
19847258
20478261
20510258
20603072
21251944
21270334
21376743
22021614
22055391
22469522
22713970
22743550
22921416
23145148
23414611
23562323
23568489
24050180
24210699
24684389
24976506
|
POLB
|
PCNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11687589
9214649
11601988
10744741
|
PCNA
|
POLB
|
â—¼ SHARES_COMPLEX
|
|
|
40.0
|
1.0
|
ACSN
|
10858306
11756412
11948190
12637553
14624239
14726013
15703371
16442856
16697054
17088286
17116881
18087292
18584027
18809224
19208614
19364882
1974050
19748837
19772495
19847258
20478261
20510258
20603072
21251944
21270334
21376743
22021614
22055391
22469522
22713970
22743550
22921416
23145148
23414611
23562323
23568489
24050180
24210699
24684389
24976506
|
RAD18
|
PCNA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10884424
15280666
15688063
16611994
16824193
17652783
18157158
18196958
18363965
18498753
19013543
19258535
19396164
20129063
20675655
|
RAD18
|
PCNA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
18363965
19706603
17652783
18196958
18498753
20129063
21227930
10884424
19013543
18157158
15280666
19258535
16611994
19396164
20675655
|
MDC1
|
RIF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
UBE2I
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15169778
15340381
15147722
12820959
10722742
19459846
18006823
10721693
19440234
|
POLB
|
RNF10
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-1.02
|
1.01
|
PKG
|
28854368
|
MDC1
|
MDC1
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-3.38
|
3.37
|
PKG
|
28854368
|
RAD18
|
RAD18
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-4.39
|
4.38
|
PKG
|
28854368
|
POLB
|
POLB
|
â—¼ KO_DOWN_REGULATES
|
✅
|
-
|
-7.24
|
7.23
|
PKG
|
28854368
|