Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CYCS APAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9267021 5221616
APAF1 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 5214497 11550094
EIF2AK3 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16595687
COX5B APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9267021 9390557
APBB1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
DVL2 APC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7890890 20224554
DVL1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20224554 10330181
CHRM5 ATP2A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ATP2A2 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
BAD APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK9 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14673001 17555943
IKBKB BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23332762
MAP2K1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15994315 15121878
BAD CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15725726
CASP3 BID â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
FAS BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
FADD BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
BID CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9873064 9727491
CASP3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP9 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 CASP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 12011067 15573119
CASP3 AKT2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP3 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10432301 10734073
CASP3 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17581882
CASP9 CASP7 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
GSK3B CYC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12851486 23109003
EP300 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20339243 21467818
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
SLC25A5 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ATP5F1B IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CANX IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
KIF5B IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SFXN1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FADD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16227629 23131831
MAD2L2 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17296730
MAPK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
MAPK1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16709866
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
MAPK3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19046355 9614189
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
GSK3B MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
MAPT CDK5 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
PSEN2 PSEN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 APOE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 CDK5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PSEN1 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22330899 22363130
PSEN1 DLL1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 22330899 22363130
PSEN1 JAG1 â—¼   UP_REGULATES ✅ 2.0 0.8 ACSN 22330899 22363130
CTNND1 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10208590 11226248
APH1B PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12522139 12471034
PSEN1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19012753 18996842
PSEN1 DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12794186
PSEN1 CTNND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10208590 11226248
TP63 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22777354 23837456
TP63 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20442293 20950370
IKBKB TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23589370 33548094
TP63 FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15944736
NGF TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APH1B TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
NGFR TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APH1A TRAF6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
TRAF6 AKT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19713527
CTNNB1 FZD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12095419 15473860
ATF4 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20617572 19648113
COX5B COX4I2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 17418790 8194600
COX5B COX4I2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 17418790 8194600
ATXN1 ATP5F1D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CALM3 ITPR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 7755592 10456332
NOTCH1 HEYL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20951801 11044625
ATXN1 ATP5F1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATP5PD ATP5F1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CYCS APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FADD FAS â—¼   COLOCALIZATION 2.0 0.8 intact 16498403 5218359
HES1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18976936 25733872
NOTCH1 DTX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14567914 15965470
NOTCH1 DLL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 20351093 22363487
NOTCH1 DLL1 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 20351093 22363487
NOTCH1 LFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15207708 22298955
NOTCH1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330899 22363130
NOTCH1 HEY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21828089 14976548
HRAS DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS KLC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS ITGB3BP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GSK3B AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
FZD5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
AXIN1 CSNK1A1L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11884395 23331499
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
FZD2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23151663 19388021
FZD3 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22944199 19388021
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
HDAC1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20609221 22422937
CIR1 HDAC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6548441 9874765
CIR1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548441 9874765
HDAC2 CIR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 14673164 22796940
HDAC2 CIR1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 14673164 22796940
APP ADAM10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ADAM10 APP â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 20676056 10097139
ADAM10 CDH1 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 18434311 15958533
HES1 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23037857 22172337
HES1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9108352 18162173
HES1 MAML1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22529374 21640102
COX5A APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
COX5A COX4I2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 17418790 8194600
COX5A COX4I2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 17418790 8194600
COX6C COX4I2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 17418790 8194600
COX6C COX4I2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 17418790 8194600
NCSTN APH1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
APH1A APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APH1A APH1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16252010 16630834
APH1A APH1B â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 16252010 16630834
APH1A NGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APH1A NGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APP NGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NGF APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APH1B NGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
EIF2S1 EIF2AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9431994 6735217
EIF2S1 EIF2AK2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 9431994 6735217
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CHUK IKBKB â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CTNNB1 CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
MAP3K5 MAP2K7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219344 17110930
LRP6 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 16273260 23371553
GOLGA2 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
DVL2 GOLGA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LRP6 DVL2 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 16273260 23371553
CTNNB1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21772333 19213727
ATXN1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
GAPDH CDK5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CDK5 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APH1B NGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 16252010 16630834
APH1B APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IKBKB EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10848580 16600570
CTNNB1 GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP GAPDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NCSTN GOLGA2 â—¼   COLOCALIZATION 2.0 0.8 intact 18201567 6174903
IDE APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TMED10 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NAE1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MME APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PSEN2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STXBP1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NOTCH4 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CHRNA7 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PSENEN APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAP2K2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AGER APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CSNK2A1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN1 ATP6V1B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CACNA1C BSG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
LRP5 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21606194
ATXN1 ELL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NOTCH2 MAML3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
NOTCH2 MAML1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
DTX4 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10531053 23331499
PSENEN NCSTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18201567 6174903
TGOLN2 NCSTN â—¼   COLOCALIZATION 2.0 0.8 intact 18201567 6174903
NCSTN LAMP1 â—¼   COLOCALIZATION 2.0 0.8 intact 18201567 6174903
NCSTN PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10993067
ELL2 PSEN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C ELL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DKK4 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 29925589
DTX2 TRIP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CHRM3 BSG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
CHRM3 MAGED2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
ATP5PF ATP5PD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ATP5F1E ATP5F1C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
APP PSENEN â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
LRP5 AXIN1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 11336703
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
TRAF6 GSK3B â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31594754 30711629 31754475 30806153
KIF5A KIF5C â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
LRP6 AXIN1 â—¼   RELOCALIZATION ✅ - 0.81 0.81 Signor 18632848
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
COX5A COX8A â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
COX6C COX8A â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
DVL1 APC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20224554 11425858
LAMP1 FZD7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AXIN1 AXIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22682247 20128690
FZD10 EBP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
COX6C COX5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31536960 23260140
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
KIF5A KLC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10491391 33961781
LAMP1 FZD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DKK4 LRP5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
COX5B COX6C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
COX5A NDUFB5 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
AKT1 BAD â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 9346240
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
APOE MAPT â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
KIF5A KLC2 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
CTNNB1 CTNND1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
KLC3 KLC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26496610
AXIN2 CTNNB1 â—¼   DOWN_REGULATES ✅ - 0.83 0.83 Signor 11940574
PSEN1 TRAF6 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CSNK2A1 HDAC1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CYC1 CYCS â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
KIF5C KLC3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 11319135
NCSTN PSEN2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
CYC1 NDUFB5 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
AXIN2 APC â—¼   PHYSICAL_INTERACTION ✅ + 0.84 0.84 Signor 10911903
CALM3 FAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MAP2K7 MAPK9 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
DTX1 NOTCH1 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
GSK3B MAP2K7 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
AXIN1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 7025676 19131971
CASP9 CASP3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11242052 8900201 25241761 1067155 15941357 11230124 15507451 18723680 17437405
HEY2 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 11486045
HEY2 HEY1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 27129302 33961781 26186194 24366871 19802006
NCOR2 HDAC2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 30737378 16481466 11013263
DKK1 LRP5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 11516963 33961781 26186194 15035989
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
APAF1 CYCS â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
DVL2 APC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20224554 26496610
ATF4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14630807 17872950 10350644 12471036 16219772
EBP WLS â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31286866 28734904
HEY1 HES1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 27129302 26068074 19802006 33961781
AKT1 FAS â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25640309 31980649
LRP6 FZD8 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11448771 11029007 15908424
ITPR1 AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24947355 18250332
AKT1 BRAF â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10869359 25241761 28628118 28205554
CYCS CASP9 â—¼   PHYSICAL_INTERACTION ✅ + 0.86 0.86 Signor 9390557
COX5A NDUFA9 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CASP3 BID â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10364179 11399776 18723680
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
KLC1 KLC4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26496610 22863883 33961781 22939629
CASP3 CASP9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
KLC1 KLC4 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CACNA1S CALM3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
APOE APP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
KLC1 KLC2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
NGFR TRAF6 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
AXIN2 GSK3B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12183362 10966653 33961781 23602568 32707033 23455922 29568061 30824926
KLC3 KLC4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26496610
KLC3 KLC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26496610
APP BACE1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
AKT1 BAD â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CYC1 NDUFA9 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSNK2A1 CSNK2A2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
COX4I2 CYCS â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
NOTCH4 MAML3 â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 12370315
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CSNK2A1 HDAC2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
FRAT1 GSK3B â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ATG13 ATG101 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8428476 23392225
AXIN1 LRP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22682247 19107203 23959799 24976009 28966723 16890161 20128690 23892894
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
HDAC1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11739383 16481466 11013263
GSK3B LRP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19107203 16890161 16365045
INS INSR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 2550426 11278498 29512653 23302862
IDE INS â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17051221 29273204 11145591
CTNNB1 PSEN1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
APP NCSTN â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
AXIN1 APC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16199882 22682247 10228155 29045831 18786926 20128690 19131971 26496610 10811618 9734785 29713058 23277359 17510365
APC CASP3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 10200466 17297457 9973322
AXIN2 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10966653 10911903 9554852
MAPK3 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19777442 10597268 12566304
MAPK1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8929531 10597268 12566304
GAPDH BID â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CAPN2 CDK5R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25969760 10830966
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
MAML1 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15546612 12050117 12391150
IKBKG IKBKB â—¼   PHOSPHORYLATION ✅ 3.0 0.9 intact 8209688 506093200 16126728
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19941816
MAPK1 KLC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21385839
MAPK1 ATP1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15069082 14976217
BRAF MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
BRAF MAPK3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 KLC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21385839
TMED10 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 16641999
TP63 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27132513 8258457 23071313
TRAF6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34938598 19713527
CSNK2A1 TTI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23263282
FZD7 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14636582 22179044 19388021
ATF4 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23009153 21146245 17141186
CALM3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
KIF5B GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
NOTCH1 DTX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10933396 9881968 15356142
HES1 DTX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20161710 20208568 16990763
NOTCH1 HES5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11741889 10520600 10205173
AXIN1 DVL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10829020 29659741 23892894 21245303
AXIN1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 17601533 21988832 10228155 24976009 30181396 20128690 12511557 17318191 16293724 23455922 28546513 17318175 19303846 18632848 19131971 16890161 26496610 23892894 23602568 22613765 18593713 29568061 21242974 22682247 19759537 11738041 22270359 24451375 9734785 32707033 21502811 17510365 10481074 16199882 26912724 23959799 29045831 22509369 29789528 19202075 12584189
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
ADAM10 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
HES1 GAPDH â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FAS MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25241761 11495919
IKBKB NGF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8837778 11244088 8599092
AKT3 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19609947
CTBP2 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21315774 16356938
DKK1 LRP6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 11448771 21984209 27322059 11357136 33961781 26186194 21944579 15035989
DKK4 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 29925589
FZD5 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857724 18077588
LRP5 DKK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19158955 18044981 17047023
CTNNB1 DKK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15592430 15592505
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
NGFR ADAM17 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 12913006 12843241 15701642
ADAM17 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
ADAM17 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9774383 12535668
ADAM17 DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19601831 19726682 19704010
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
APH1B PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12297508
APH1B NCSTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857757 12297508
GSK3B GAPDH â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
APP GAPDH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21832049 16713569 8473906
APP NAE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25568892 16189514 8626687
AKT2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10869359
GSK3B FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B FRAT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11738041 29568061 26496610 23602568 23455922 12095675
GSK3B CDK5R1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
KLC1 KIF5A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 3130248 1607388 3134048
APOE LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9832610
MAP2K7 MAPK8 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAP2K7 MAPK9 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MAP2K7 MAPK10 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MFNG DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12036964
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CDK5 MAPT â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EIF2AK2 EIF2S1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
KIF5A KLC4 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
KIF5B KLC4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PSEN2 PSENEN â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
KIF5B KLC2 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
AXIN1 LRP6 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
JAG1 NOTCH1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CALM3 CACNA1C â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 8087759 20953164
AXIN2 GSK3B â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
DKK1 LRP6 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CDH1 CTNND1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CDK5R1 CDK5 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 23543736
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
APP IDE â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
BRAF KRAS â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
COX5B CYC1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
AKT3 MAP3K5 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
CTNNB1 AXIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
KIF5A KLC1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
IKBKG TRAF6 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
COX5B COX6A1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
KIF5C KLC1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
COX5A COX6A1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CDK5 CDK5R1 â—¼   PHOSPHORYLATION ✅ - 0.94 0.94 Signor 18326489
ATP6V1A ATP6V1B1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
KIF5B KLC1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
IDE INS â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
NOTCH1 MAML1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 23022380
KLC2 KIF5C â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 9624122 26344197
KLC2 KIF5A â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10491391 22939629
KLC4 KLC2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 22863883 30217970 26496610
COX6A1 COX6C â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
COX5A COX6A2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
COX6A2 COX6C â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
AKT1 MAP3K5 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BRAF MAP2K2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CASP9 APAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5221774 9390557
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
AKT1 BAD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15998799 10358075 25241761 11500364 9381178 11994280 23085457 15722337 19667065 15784622
FAS FADD â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5219431 17159907
FAS FADD â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16498403 5218359
PSENEN PSEN1 â—¼   CLEAVAGE ✅ + 0.96 0.96 Signor 12522139
MAP2K1 MAPK3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
APC GSK3B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11166179 29045831 21118991 8638126 11251183 23602568 29568061
AXIN2 CTNNB1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
KLC1 KLC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 26496610 22863883 33961781 17332754 22939629
INS INSR â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
MAP2K7 MAPK8 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
APP PSEN1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
IKBKG IKBKB â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219009 16938294
IKBKB IKBKG â—¼   PHOSPHORYLATION ✅ 0.98 0.98 mint 8209688 16126728 506093200
KIF5C KLC1 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 10491391 33961781 9624122 26344197
KLC1 KIF5A â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 10491391 33961781 9624122 22939629 26344197
PSEN1 PSENEN â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CACNA1C CALM3 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
APH1A PSEN1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
APH1A PSENEN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
APBB1 APP â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
APH1A NCSTN â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
APAF1 CASP9 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
AXIN1 DVL2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
NCSTN PSENEN â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ATG101 ATG13 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
COX5A CYC1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
NCSTN PSEN1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
NDUFA9 NDUFB5 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MAML1 NOTCH1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
TMED10 TMED2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BRAF MAP2K1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GSK3B MAPT â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
AXIN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDK5 CDK5R1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CHUK IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IKBKB IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
AXIN1 GSK3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CYCS APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11753565 10393175 10364241 15829969 16977332 15907471 10722681 9390557 10578178 16713569 9267021 12147322 10206961 10329646 11112785 10940292
CASP3 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12874265 21827945 11550094
APAF1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 17145710 15829969 15024710 9390557 19494828 11113115 10617566 9539746 10364241 10722681 27476169 21060833 19118655 20829884 16977332 10329646 15210107 10393175 16352606 11242052 14555243 10376594 12773388 10206961 19337385 10428850 9488720 19788417 15262985 9922454 21827945 10749135 9651578 19698783 12792650 9837928 11227497
MAPK1 APBB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14697653
APC AXIN1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
APC AXIN1 â—¼   PROTEIN_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
CHUK APC â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11955436 11967263 12051714 12799363 23430059 7542250 8666229
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
AXIN1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16199882 20128690 19131971 11297546 9554852 22682247 10228155 26496610 23277359 10811618 9734785
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
ATG101 ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 20562859 23392225 26299944 19287211 24290141 19597335 24100292
AKT1 BAD â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
MAPK8 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 11983683 12189144 14673001 16166315 15526032 29795446 15907327 14967141 15725726 17555943
AKT3 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 23109003 12954615 22094462 10949026 15023346 17680028 18218901 17270021
AKT1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 137.0 1.0 Omnipath 10880354 19052636 21506126 20028971 21303971 20214616 11994280 8929531 17570479 12832477 17555943 25241761 11715018 18636226 21998731 9812896 17680028 11500364 18385666 18707149 10201527 18218901 11983683 10490655 19030972 19667065 11756412 11020382 16931767 18372248 15808505 20138985 18046313 18669648 19121340 19703413 11714830 10949026 15972258 16341064 10358075 23085457 18220336 10516287 12897128 9580112 9651683 11923280 9346240 16697215 19690332 11493700 15452053 12040186 10826997 12175651 15722337 14737178 11882383 15226424 10521512 15023346 15784622 17052453 16044149 16403219 12444011 20166139 20398329 9381178 11544290 15037618 12767520 15280015 10230394 10558990 15998799 10082559 11577096 10837486 15169778 10611223 23109003 12954615 22094462 11438654 11312610 11254732 21540285 10383455 19664994 10722653 20832730 18570873 10926925 17270021
AKT2 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 15452053 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 12954615 22094462 10949026 11438654 17680028 10516287 18218901 17270021
CAPN2 BID â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11404357 11940658 17264306 18469004 21887410 23242420
CSNK2A2 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11583622
MAPK8 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18594987 25326334 25077544 27374471
CAPN2 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18469004 12000759 20709625 17264306 21670566 11404357 21738214 16129881 17593948 21266584 11940658
CASP3 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9727492 10364179 10805722 11832478 11085742 11085743
CSNK2A1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11583622 12598529 20356928
MAPK3 CAPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11319218 26248159 14993287 10644690
MAPK1 CAPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11319218 14993287 10644690
CASP9 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10708865 9390557 10508159 11230124 18723680 15657060 16977332 15507451 1067155 9708736 25241761 8900201 11242052 9765224 17437405 19788417 9812896 12620238 15941357 12181739 19465923 12792650 15725726
CASP3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12888622 16606369 22535953 11162250
CASP3 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9367996 11741536
CASP3 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10069390 16189514
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CASP3 PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10069390 9219695 9990034
CASP9 CYCS â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9390557 25313070 20462491 27697150
CASP7 CASP9 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 16916640 9922454 11752425 11701129 12824163
MAP2K2 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12792650 18669648
AKT1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 11756412 11923280 16697215 20398329 18372248 15004527 15808505 20138985 20214616 15703181 17570479 28177918 18840507 15169778 11714830 10949026 16341064 11715018 18636226 10529400 9812896 17680028 19440551 10722653 20832730 18570873 17052453
AKT2 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9812896 15004527
AKT3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9812896
CYCS CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19788417 16977332 9390557 16713569 12147322 12773388 10329646 12792650 15210107
MAPK3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 15547943 20080742 29416675 12040186 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
MAP2K1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12792650 18669648
MAPK1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 15547943 20080742 12040186 18083711 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 16888006 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
CASP9 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17899380 9922454 16352606 9598997 9651578
DVL2 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
DVL1 CSNK2A2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A2 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17570479 17287340 19413330 18669648
CSNK2A2 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19651622 19415658 12082111 16565220 19007248 19691289 18669648 20166139 18691976 17081983 20230923 20068231 18452278 17570479 17287340 19413330 18510355 18212344
CSNK2A2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12700239 19141652 12432063
CSNK2A2 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 26186194 27705803 25519132 19011756 26496610 25852190 23455922
EIF2S1 EIF2AK3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 18664456 12370288 16288713 17956313 11907036 10026192
EIF2AK3 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 76.0 1.0 Omnipath 25429617 25579745 14967143 17998059 21981022 27009865 10504407 23356742 3352609 26622781 24316205 24706853 16288713 20408811 30070006 18840095 27638465 21844328 21029306 23293645 21901118 29199180 30081573 14638860 19007793 9819435 23935851 8099443 21029301 19220912 31226023 25660019 22509299 22169477 11337501 24904562 15314157 9930704 23314846 17998206 17325203 16179258 25393282 19583950 26028033 29396442 26487695 10542257 18694499 1677563 11555640 24705207 20040105 24159375 25541374 24958502 11907036 29163417
EIF2AK3 ATF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19029953 15550948
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
MAML1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19304754 16530044 12391150 12050117
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
DTX1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11564735
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
ERLIN2 KRAS â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
ERLIN2 HRAS â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
TRAF6 IKBKG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18180283 18347055 21220427 16547522
IKBKG CHUK â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
IKBKG CHUK â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
FADD IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
IKBKG IL6 â—¼   DOWN_REGULATES ✅ - 38.0 1.0 ACSN 10542212 10754326 10952726 11875494 12133805 12907458 14660645 15199157 15465827 15485931 15536066 15644117 15749903 16243976 16413922 16818229 16878026 16970925 17237376 17254973 17363905 17404308 17485448 17693255 18716620 20138012 20300203 21217011 21807870 22435554 23086447 23390297 23422957 23430059 2649237 28462531 7594497 9743347
TRAF6 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17562858 17728323 17947236 14695475 18180283 15620648 15125833 12867425 11057907
AKT1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20837477 20098747 17660512
IKBKG IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 150.0 1.0 Omnipath 17145710 16938294 20932476 35339487 18266324 16260493 27929056 25979343 19666608 26496610 12133833 12192055 9751060 21423167 19706536 15836773 17561400 22099304 23986494 19959994 15327770 25400026 24266532 18450452 12657630 20434986 11583588 20200955 20300203 21903422 22990857 14743216 20167598 20098747 16126728 19656241 25852190 16906147 10195894 17000764 18329793 16186825 16547522 16611882 18037881 10968790 16497931 25286246 18462684 18207244 16603398 17965022 17977820 24240172 17568778 15084594 16129692 23506214 16319058 23123196 18949366 15218526 22605335 20368414 10837071 19820708 10980203 23131831 17363973 15214841 25304104 16493424 15184390 15691841 11864612 15802604 17693255 21455180 11865184 20211142 11971985 16970925 24469399 24618592 12486103 11057907 24369075 19365808 18583959 27426725 12612076 19422324 10094049 23109003 21803029 12459277 21640763 16285893 18266467 12709429 15620648 17072322 19815509 15749833
IKBKG CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17145710 17485448 16938294 11865184 11877453 16970925 22435554 17244613 17568778 17363905 16818229 15084594 15485931 24369075 20300203 21217011 12799363 23180781 14743216 16319058 21703539 19666608 20098747 12612076 16126728 15218526 23430059 9751060 20138012 18716620 20368414 10837071 25355947 15836773 23109003 20531300 17702576 17363973 15214841 12459277 17561400 21640763 16285893 28462531 12709429 10968790 15199157 26192618 12133805 16497931 11864612 17693255 17072322 11340079
MAD2L2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20074045 11459826
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 9614189 9832145 12387894 12766916 12765608 12414518 19413330 1330687 24116116 19415658 15302935 33961674 9716264 34493616 31178717 28066266 15324364 31065832 25573097 12801934 29298849 16165272 15883264 16115884 8166686 33952699 9565682 11181841 34536819 10737616 7566346 18315566 9771888 29760653 34480088 24301651 15542598 18055457 12226093 7488031 9199504 18510355 21731772
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404396 9528799
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
MAP2K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 9694850 17081983 11319218 18799465 17389395 9447970 15342917 8226933 15851026 12270934 12644307 11242034 1381507 17906627 9677429 11986622 8376945 7992057 11948414 7687743 9731057 19197339 11704645 7565670 12750173 12932319 8626767 23331499 12048245 7559390 17272394 15811950 26987942 19494114 18669648 18691976 17192257 8388392 7898932 16464493 19369195 12920017 15466214 19690332 11134045 19534553 10995751 7867743 8223433 8248196 10567369 19933846 17563371 1518847 11730323 18983981 16186792 16135787 15951569 19058874 15212693 10748187 9560161 9925641 9733512 18083107 11104681 9006895 17569879 21071413 7731720 1330321 93330262 19541618 15466476 12925710 11971971 11136732 11118451 10746662
MAPK3 ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12058067 18187448 21570469
MAPK3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MAPK3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 14654779 21478863 19541618 21135229 16508002 19933846 15664191 8621729
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
MAPK8 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 34342183 17314187 33557920 15312816 17761554 33762974 33842885 12614922 15136685 17270732 15228592 28758999 34385305 8506352 15994305
CDK5 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 103.0 1.0 Omnipath 16697218 26944284 21945393 9614189 7592534 9832145 19562805 12387894 21848865 27641626 24268883 9546672 12071639 19413330 1330687 19415658 15302935 9353289 21671254 20508838 8282104 20068231 26998748 16568235 21215781 17045592 9565682 11181841 7566346 12435421 17287340 9771888 15843619 17078951 22761989 24367683 19651622 1181841 9735171 11104762 12226093 9199504 18510355 11311121 2387894 28785087
GSK3B MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 141.0 1.0 Omnipath 19616957 22278060 25641096 9832145 19562805 12387894 24268883 9546672 31640277 21865886 19413330 28386764 28379300 1330687 28734998 19415658 15302935 17047304 7706316 27349344 29408874 9716264 9353289 21671254 24165324 12714590 20068231 12387897 17570479 16452634 25815351 21215781 16568235 16519507 8999860 17045592 9565682 27857758 11181841 14690523 22690349 27073700 21443865 10601262 7566346 10737616 15522877 12435421 17287340 9771888 29725295 15073173 17078951 19651622 1181841 15542598 9735171 12226093 11104762 21985244 20049527 28835279 27965573 20679343 20308788 9199504 18510355 10090741 11311121 2387894
APOE MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9512010 8620924 7566652 9147408
NOTCH1 PSEN1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
PSEN1 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
PSENEN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12522139 12198112 15322109 16189514 21115843 12639958
GSK3B PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11104755 17389597 17360711 16814287 10997338
NCSTN PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 12603837 23331499 21071413 14572442 12471034 10993067 18201567 18988627 12032140
CASP7 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10069390 16189514
MAPK9 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18667537
APH1A PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12522139 12471034 16189514 12297508
CDK5 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12056836 15917097
PSEN1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11518718
PSEN1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
PSEN1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10593990 10077672 16713569 10206645 12374741
PSEN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17145710 11168528 16126725 11226248 2195779 11161700 12070348 9738936 10037471 18070361 9632714 10092585 9223106 12297048 16306047 10341227 9852041
PSEN1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10635315 11226248 16126725 11953314
TP63 JAG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23863842 11641404 23837456
TRAF6 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18292600 9774977 10523862 10921914 17724081 15310755
TRAF6 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15836773
TRAF6 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16260493 15691841 15620648 15327770 10195894 16186825 16493424 17965022 10094049 10837071
TRAF6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
DVL2 FZD7 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
EIF2S1 ATF4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
CTNNB1 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24447505 15473860 11809809 22615875 11809808 12711682 11940574
HDAC1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
CTNNB1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10966653 19751508 7542250 8666229 17143292 11955436 11967263 23343194 22270359 9554852 22699938 16039586 16940750 9566905 19619488 15766563 12051714
AXIN2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15611123 10966653 10911903 888800000547 9554852 22745173 9566905 22322943
COX5A COX5B â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX6C COX5B â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX5A COX5B â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX6C COX5B â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX6C COX5B â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
INSR CALM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17389395 19901323 18578522 12153558 18707149 20068231 16497976 17287340 15592455 2843348 7925415 3415247 8639568 17016520 18669648
CALM3 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9952395 8625412 12379661 9728925
NOTCH1 HEY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11486044 11095750 11486045 12814948 20007915 11971902 11741889
GSK3B CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15288510 16288047
FADD FAS â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FADD FAS â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
MAP2K7 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11034606 10640736 16061179 15001534
FAS FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 22864571 8521815 11717445 21713032 16762833 23606538 8967952 20935634 7538907 21803845 9325248 19118384 12721308 21959933 18328427 16189514 25563855 10196099 17159907 27321185 26186194 25241761 9880544 16498403 21625644 9082980 12107169 15659383 15993755 21382479 7536190 11464215 26942442 11035039 15725726 16410793
DTX1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11153911 20208568 23331499 21071413 11226752 11564735 22162134 18988627
NOTCH1 JAG1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
ADAM10 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM17 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
NOTCH1 JAG1 â—¼   LOCALISATION ✅ 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 HEY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11486044 11486045 10964718 12814948 14739937 20007915 11971902 21956839
NOTCH1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10520600 11120788 10066785 16869730 12814948 7566092 21956839 9819428 10933396 11866432 20007915 10205173 11741889 19165418 15546612
ADAM10 NOTCH1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
NOTCH1 PSEN2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 10879540 10206645 12209127 9620803 19151708
DLL3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 29910816 16921404 16140393 18676613 10958687 22353464
DLL1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17537801 11006133 9819428 21685328 1006133 16140393 98194281 22353464
PSEN2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
MAML3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23022380 23331499 12370315
LFNG NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10935626 16713569 12486116
ADAM10 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19726682 28624438 19704010 19601831 22399336
GSK3B NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16944320 15465828 12123574 11967263 14663202 8524413 21828089 16713569 9832503 15020233
ADAM17 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10882063 19726682 19704010 19601831 9620803
MFNG NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16713569 10935626 12486116
MAML1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 23022380 16530044 11101851 19907488 22100894 21820430 12644465 16713569 12370315 11997524 18427106 11390662
JAG2 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23331499 21071413 16921404 11006133 1100613311006130 22503540 16713569 10958687 18988627 9315665 21352254 22353464
JAG1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18495817 16921404 15137944 769772111006133 16713569 23331499 21071413 23086448 22363130 18988627 21820430 18292500 18660822 22330899 17537801 11006133 7697721 10958687 22353464
NOTCH1 HES5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17537801 16283144
NOTCH1 HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23343194 19000719 18495817 16039586 19619488 17143292
NOTCH1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18560356 23331499 23180781
NOTCH1 LFNG â—¼   GLYCOSYLATION ✅ 5.0 1.0 Reactome 10734111 16385447 9187150 10935637 9207795
ADAM10 JAG1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
MFNG JAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12036964 23331499 15574878
JAG1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 23331499 18660822 22330899 21071413 16921404 18988627 10958687 22363130 10551863 22353464
JAG1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22330899 16921404 11006133 14714274 22363130 18660822 12482954 22353464
JAG1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 29910816 22330899 22363130 24563863 22353464
HRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11525649 8137421 16810318 16713569
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
DVL1 AXIN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FRAT1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 DVL1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 FRAT1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 DVL1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
CHUK AXIN1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11955436 11967263 12051714 12799363 23430059 7542250 8666229
DVL2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10329628 10829020 21245303 23892894 16713569 17529994
GSK3B AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 20128690 16944320 11738041 20043192 12511557 11967263 16890161 22613765 14663202 23602568 8524413 24451375 19303846 12554650 8638126 22509369 18593713 16199882 21988832 23331499 19759537 10428961 9482734 22270359 19202075 17570479 16293724 15327768 10581160 17318191 11487578 22773187 26496610 16568235 17318175 19131971 15465828 26912724 25241761 24976009 21242974 22682247 10228155 23579495 12584189 23959799 15020233 10421629 10488109 11278246 9501208 18632848 10481074 10535959 10318824 9554852 17601533 9832503 21502811 9734785 23455922
LRP6 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20128690 23331499 8666229 12897152 10428961 24976009 16890161 18632848 22682247 23959799 16340998 18988627 19107203
LRP5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8666229 11336703 10428961 18632848 21071413 19075000
DVL1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12556519 11278246 10862053 10330403 10330181 10428961 9482734 10196136 11027605 18339531
AXIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 20128690 20531388 16890161 27902311 22509369 18593713 16199882 23331499 9482734 21071413 26496610 19244247 22773187 17318191 10196136 18988627 17208333 19131971 24976009 22682247 10228155 12805222 12000790 10488109 9501208 9601641 18632848 9554852 19166851 23959799 12421363 9734785 11940574
DVL1 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 FRAT1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL1 FRAT1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL1 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10837139 20976471 10806215 25241761 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 16707567
DVL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 25241761 10806215 20006983 15735151
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20580679 19182791 21685935 21184735 24424621 18794357
CSNK2A1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17287340 19413330 22113938 18669648
CSNK2A1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 19007248 16565220 20166139 17081983 20230923 25609639 19413330 19415658 20388487 20068231 18452278 18669648 18691976 17287340 12176973 19651622 12082111 19691289 24526703 18510355 18212344
HDAC2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15169839 17615296 25241761 22796940 20818389 21685935 15388328 20519943 12508111 11309385 17018611 22514743 19597490 14673164
ADAM10 ADAM17 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM10 ADAM17 â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM10 DLL1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
DLL1 ADAM10 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
ADAM10 NOTCH2 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 22658936 20156974 10958687 24842903
ADAM10 JAG2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
ADAM10 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 24842903 19726682 19704010 10423016 19601831
ADAM10 DLL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19601831 12794186 19726682 19704010
ADAM10 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 32814053 30538620 12535668
ADAM10 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12651094 23331499 19726682 19704010 19601831
HES1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22457355 11549279 17300753 22113197
NDUFB5 NDUFA9 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFB5 NDUFA9 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094
NDUFB5 EIF2S1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
NDUFB5 EIF2S1 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
COX5A COX6C â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX5A COX6C â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX5A COX6C â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
NCSTN APH1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15189355 21071413 14572442 12471034 12857757 18201567 12297508
APH1A PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12471034 16189514 12297508
APH1A PSENEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12522139 15322109 12740439 16189514
NGF NGFR â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 9841888
NGF NGFR â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 9841888
NGF NGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 10764727 11729324 16893414 2172988 1372492 24224055 14985763 22227462 11114882 15258592 14699954 3037029 1714587 9775403
EIF2AK2 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 85.0 1.0 Omnipath 28167698 11432733 28781602 20685959 9335428 10504407 3352609 24178712 25687824 17290288 24706853 16288713 19043413 19259124 23399035 21738672 8626809 9431994 21899699 11985496 2912723 23259068 28670265 19364808 2116318 9819435 23706307 8099443 8096514 31226023 18096616 15550948 8099444 17372663 24335187 11337501 9930704 21377708 23056444 21418572 18971339 16179258 20149255 19583950 28623239 10542257 21368187 1677563 22174864 11452027 24909749 20040105 12737801 16179259 16289913 25521494
AKT2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19609947 12048203 10485710
EIF2AK2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10723127 10648614
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
CHUK NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18374649 16846590 23041317 23343355 16382138 15494311
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
CDH1 CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GSK3B CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16944320 11348595 11967263 14663202 8524413 20080742 19797085 12040186 16611981 10671551 16039586 12615961 15465828 17928543 24063632 10671552 15020233 19575820 17444818 20537194 17052453 9832503 18455992 16371461 11274345
CTNND1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 7542250 17261850 22752307 9535896 7651399 12707304 23180380 24424122 12640114 11226248 29207493 10225956 12427869 21670201 22850631 20371349 20940130 25468996 10409703 14610055 7876318 22715382 10629228 19711372 8660921 10931041
CSNK2A1 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10837139 11348595 20976471 17928543 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 10671552 16707567
CDH1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 91.0 1.0 Omnipath 17145710 7542250 11348595 9512503 10652321 19016843 16909210 9233779 17220478 16219695 27177845 25344754 11245482 22752307 16983094 16212417 16574648 18593713 9535896 9819408 12830000 10772923 11801604 23180380 8227214 16546130 10085258 22056988 9700170 12640114 24424122 10381631 17087658 24798214 11226248 12875984 9405455 11712088 12061792 17909039 22158051 11960376 14706341 11254878 15023525 12169098 21255999 16125672 22850631 16126725 11113628 25468996 9326449 17524503 17057644 7876318 11401320 22715382 7954478 18593907 21152425 22375065
MAP3K5 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
AKT2 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14500571 23603750 12697749 11154276 27363949
AKT1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 16532036 14500571 11154276 30677014 17184578
MAP3K5 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17634293 20348951 15247305 21785467 12194869 12221076 18818208 18029441 19667122 21726807 16760468 21212517 19749799 26147002 25310587 33573023 26375285 16648474 15944157 7839144 12456653 25915038 26853469 21856198 31575661 10521505 25702873 19029119 20156337 16928747 15020250 20452983 15242986 18570871 16845370 20871632 21040800 27203743 19783996 21931634 23608534 21697492 25619840 26964622 12758252 16632641 28881794 17210579 34048499 20921231
MAP3K5 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 12556535 19392652 18855897 17462996 19920149 18641653 23331499 23850759 21071413 12655147 21614932 21133840 12738796 21232017 24378531 15592525 11959862 17110930 26192618 11274345
DVL2 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
LRP6 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
LRP6 FZD2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
FZD8 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11448771 21078818 11029007 20093360
GSK3B LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22357953 23331499 19107203 21606194 16890161 21709260 16340998 16365045 19366350 21406690 16341017 17318175
DKK1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 23331499 19339249 21071413 12527209 21944579 11448771 21984209 11357136 11516963 18988627 29925589
CSNK1A1L LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 21606194 20229235 19293931
LRP6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 25088803 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
DKK1 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19101658 11448771 18786602 16307379 11516963
GSK3B FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
FZD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
CSNK2A1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 29732088 17374729 21506126 11689703 10671551 12149249 15818404 10747897 10837139 20976471 19662498 21285348 11035045 11707428 21735093 17444818 20558317 11972058 16707567
INS AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 29432553 23912456 11679435 23866690 17335965 24646332 23798298
AKT1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 20058876 14688280 11510412 25241761 20230923 20068231 18452278 11410590 17570479 10869359 18669648
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 ITPR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24947355 18250332 16332683 18955969
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 ATXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 15757972 15824120 17540008 34302818 24903464 29212253 33709453 12741986 17570479 21722762 29758256 23719381 20037628 23213356 12757707 24858692 20477910
ADAM17 DLL1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM17 ERBB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15534001 15746097 10744726 9685416 26554003 17486069
CDK5 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11823425
CDK5 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18691976 25971971 8114697 11684694 15665076 10567369 8157000 12609978
CDK5 CDK5R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11583627 23602568 15689152 11389014 17036052 25076872 21220307 15890360 16189514 23979715 26186194 17591690 17762160 14521924 20133653 22654103 28637746 12223541 23543736 18326489 28077789 17121855
CDK5 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18833287 15178331 15917097 11877420 17085446 16554819 21947912 8131745 11517218 17459339 14970211 10341243 16705182 24610780 22112898 8764598 14557249 16223726 19455415 19090995 10936190 11146006 15944381
CDK5 STXBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12963086 15489225 16189514 9933594
CDK5 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 27443506 22870316 20685978 11675505 28045138 22836916
INS INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8393875 21743783 21317886 24296476 26374090 29069585 26245346 16956584 19902173 20332342 23363978 23331499 18988627 23302862 22832498 2550426 15870194 11278498 19752148 29512653 23304064 24633815 17227660 22521887 23223021 30197476
IDE INS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11145591 17051221 29596046
INS AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 25304263 30179516 23832510 23801578 22307032 20041157 24725432
MAPK10 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8131745 14970211 22958823 11877420 24610780 15936948
APOE APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9202294 10559559 10428074 10842709 17116874
BACE1 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 30538620 22801501 10677483 20418918 12901838 10531052 10931940 32814053 28923680 28869759 19251705
MAPK8 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12917434 14970211 24610780 20122754 15936948
KRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
BRAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 20212043 7706312 25437913 9560161 7936666 14970219 18567582 18332145 8413257 23331499 15342917 21071413 7731720 7873542 26496610 10976102 18988627 17667937 16255777 8131746 16888650 15485920 8394352 15175348 15466476 19541618 25600339 25155755 17563371 16810323 8157000 17979178 18039929 94178255 23934108 7835430 7624324 24746704 16135787 7935374 8039496 8621729
MAP2K1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17081983 21105670 16964243 14617795 30711629 18547980 8382613 17188038 17192257 15020233
KRAS BRAF â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 24937142 16294014 12932339 7744815 9020159 15035987 16364920 11325826 16041367 24347342 12932319 10205168 21441910 23993095
KRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 1386920 23331499 19541618 8601312 14970219 18567582 16135787 12932319 17563371 12917261 19933846 21779497 17635919 19223544 15710605 8073291
AKT3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10869359 18451171 11293329 19493313
BRAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 15342917 18039929 19541618 7706312 15466476 25600339 7731720 16135787 17563371 33226073 8668348 17667937 16255777
CSNK2A1 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11062067
CSNK2A1 MME â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22767595 20957047
CSNK2A1 PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8972483 9558331 20068231 9990034
CSNK2A1 GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 29423241 15537897
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
GSK3B FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
FRAT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 23331499 11738041 23602568 10428961 18498136 26496610 9635432 16982607 12095675 23455922
AKT3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 12851486 15023346 21303971 11882383 17680028 9065430 23109003 20214616 22094462 23552696 20398329 21506126 20028971 12040186 18218901
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
GSK3B NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 16944320 15465828 11967263 14663202 8524413 20068231 12794074 21828089 17570479 9832503 15020233 18669648 15302935
CSNK1A1L CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 11955436 17172446 12000790 19293931 11818547 12114015
AKT2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 17287208 20398329 21506126 20028971 12040186 18218901
FZD5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
AKT3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MAPK9 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 19623618 18423204 25639486 22074626 19667122 18604449
MAPK10 KIF5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24953741 26794516 19525941
KRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAP2K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 12821118 10713157 11489946 17145710 9362518 13130464 18855897 19690332 95141073 24975362 23331499 7839144 21071413 18362184 11062067 21614932 15911620 12738796 18436711 11389443 10506143 11242024 11847100 18669648 16153436 15725726 25241761 18691976 14523011 25284480 16076903 17192257 11390361 15755722 16533805 19369195 9312068 9207092 9733513 12758252 12624093 15212693 11274345
PSEN2 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
DLL3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 29910816 11823422 16921404 22353464
LFNG NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11346656
MAML1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11101851
PSEN2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
MFNG NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11346656
DLL1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21685328 10958687 22353464 23111325 9244302
MAML3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315
JAG2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 21071413 16921404 16713569 10958687 18988627 22353464
PSEN2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
JAG2 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23331499 21071413 16921404 11006133 1100613311006130 16713569 10958687 18988627 22353464
DLL1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 21685328 11006133 12482954 22353464
DLL3 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921404 29910816 22353464
MAML3 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 12370315
MAML1 NOTCH3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11101851
MAML1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11101851 11585921
FZD8 LRP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11448771 21078818
MAP2K7 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 11489946 9362518 18855897 23331499 9890973 11062067 21614932 12738796 11389443 11242024 12624093 11847100 16153436 16076903 17192257 15755722 19369195 19822663 14523011 11274345
MAP2K7 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 11489946 9362518 18855897 18083107 10715136 23331499 9890973 11062067 21614932 15911620 12738796 11389443 11242024 12624093 11847100 18691976 16076903 14523011 15212693 11274345
DLL1 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29910816 22353464
CASP7 PSEN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10069390 9219695 9990034
PSEN2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11518718
JAG2 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 29910816 22353464
MAML3 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315
DLL3 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16921404 29910816 22353464